CN105705175B - Apparatus for purifying blood and its method for pre-charging - Google Patents
Apparatus for purifying blood and its method for pre-charging Download PDFInfo
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- CN105705175B CN105705175B CN201480061260.8A CN201480061260A CN105705175B CN 105705175 B CN105705175 B CN 105705175B CN 201480061260 A CN201480061260 A CN 201480061260A CN 105705175 B CN105705175 B CN 105705175B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3643—Priming, rinsing before or after use
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3643—Priming, rinsing before or after use
- A61M1/3644—Mode of operation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3643—Priming, rinsing before or after use
- A61M1/3644—Mode of operation
- A61M1/3649—Mode of operation using dialysate as priming or rinsing liquid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3643—Priming, rinsing before or after use
- A61M1/3644—Mode of operation
- A61M1/3652—Mode of operation using gas, e.g. air
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- Heart & Thoracic Surgery (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- External Artificial Organs (AREA)
Abstract
The problem of the present invention be provide it is a kind of can be while operability when maintaining preliminary filling, positively carries out the apparatus for purifying blood and its method for pre-charging of the bubble discharge of blood purification mechanism on one side.Wherein, following steps of exhausting are carried out：In preliminary filling, above-mentioned blood pump (4) is carried out reverse drive and magnetic valve (V3) and magnetic valve (V6) is in open mode, thus, overflow line (L) and priming fluid supply pipeline (Lc) is open, while the dialyzate as priming fluid is supplied from the priming fluid supply pipeline (Lc), while discharging priming fluid from overflow line (L).
Description
Technical field
The present invention relates to the dialysis treatment using dialyzer etc., while making the blood extracorporeal circulation of patient, while to it
The apparatus for purifying blood and its method for pre-charging of purification.
Background technology
Typically in dialysis treatment, using the blood extracorporeal circulation for the patient for making to have taken, then return it in vivo
Blood circuit, the blood circuit is mainly made up of such as arterial side blood circuit and venous side blood circuit, the arterial side blood
Liquid loop and venous side blood circuit can be connected with the dialyzer (blood purification mechanism) with hollow fiber membrane.In the arterial side blood
Liquid loop and the respective front end of venous side blood circuit, are provided with arterial side puncture needle and venous side puncture needle, and they distinguish
Patient is punctured, so that the extracorporal circulatory system of blood when carrying out dialysis treatment.
Wherein, in arterial side blood circuit, it is provided with the blood pump of extrusion pressing type, on the one hand, by driving the blood pump,
Blood is sent to dialyzer side in vivo from patient, on the other hand, in arterial side blood circuit and venous side blood circuit, even
Arterial side air pocket room and venous side air pocket room are connect, after de-soak, the internal of patient is returned blood to.
In addition, the upstream side (that is, arterial side puncture needle side) of the blood pump in arterial side blood circuit, is connected with priming fluid
Supply pipeline, the priming fluid supply pipeline is used to priming fluid being supplied to inside blood circuit, before dialysis treatment, can carry out
Priming fluid is flowed through in the element of blood circuit, the blood pathway of dialyzer and the air pocket room that is connected with blood circuit etc.
And the preliminary filling filled.
But, when carrying out preliminary filling to the blood pathway of dialyzer by priming fluid, in order that inside the blood pathway
Bubble is moved upward, it is necessary to make blood export mouth upward, by the way that bubble is exported into venous side blood circuit side and
Discharge, in this regard, be the occasion for carrying out preliminary filling under the state to dialysis stream with dialyzate, because blood and dialyzate are reverse
Flowing, dialyzate is from above towards flowing underneath, due to the moving direction with bubble on the contrary, therefore by by the upper and lower side of dialyzer
Reversion, makes dialyzate flow upward from below, thus, it is ensured that bubble is successfully moved, can carry out more certain bubble
Discharge.
But, as described above, in preliminary filling, the occasion that will be inverted above and below dialyzer, only this just can cause operational deterioration,
And having the automation of preliminary filling becomes undesirable condition as difficulty.In order to eliminate the undesirable condition, carry in the prior art
Go out to have following apparatus for purifying blood, wherein, dialyzer blood introducing port upward in the state of, overflow is carried out successively
Step and circulation step, in the bleed steps, stop blood pump, and overflow line are opened, thus, by priming fluid from pre-
Topping up supply pipeline, venous side air pocket room is supplied to via venous side blood circuit, and from overflow line discharge, in circulation step
In rapid, reverse drive is carried out to blood pump, and overflow line is closed, by priming fluid from priming fluid supply pipeline, via quiet
Arteries and veins side blood circuit and dialyzer are supplied to arterial side blood circuit, in circulation step, the detection of venous side bubble testing agency
Bubble, thus, goes to bleed steps (with reference to patent document 1).
Prior art literature
Patent document
Patent document 1：2010-No. 273693 publications of TOHKEMY
The content of the invention
The invention problem to be solved
But, in above-mentioned existing apparatus for purifying blood, although can one side Maintenance dialysis device blood introducing port direction
The state of top, while preliminary filling processing is carried out, still, such as being connected with arterial side air pocket on arterial side blood circuit
The occasion of the type of room, with following danger, i.e. in circulation step, retains in the blood introducing port vicinity of dialyzer
Bubble makes the liquid level of arterial side air pocket room too low in the internal flow of the arterial side air pocket room.In the occasion, controlled carrying out blood
Before treatment step, must be requested that forcibly discharge the bubble in arterial side air pocket room, the operation of suitable liquid level is formed, with pre-
The problem of filling operational difference.
Proposed the present invention be directed to such situation, present invention offer is a kind of can be operational when maintaining preliminary filling
Meanwhile, positively carry out the apparatus for purifying blood and its method for pre-charging of the bubble discharge of blood purification mechanism.
Technical scheme for solving problem
Invention described in claim 1 is related to a kind of apparatus for purifying blood, and the apparatus for purifying blood includes：Blood circuit,
The blood circuit is made up of arterial side blood circuit and venous side blood circuit, and can be by the blood of patient from the arterial side blood
The front end extracorporal circulatory system in liquid loop is to the front end of venous side blood circuit；Blood purification mechanism, the blood purification mechanism, which is situated between, to be located at
Between the arterial side blood circuit and venous side blood circuit of the blood circuit, the blood for flowing through the blood circuit is carried out net
Change, and formed and make the blood pathway and make dialysis that the blood of patient flows through via the membrane for purifying blood purified to blood
The dialysate circuit that liquid flows through, the blood purification mechanism have blood can be imported in the blood pathway blood introducing port, can
By blood, blood export mouth, the dialyzate that can be imported dialyzate in above-mentioned dialysate circuit are imported derived from the blood pathway
Mouthful and can by dialyzate derived from the dialysate circuit dialyzate export mouth；Blood pump, the blood pump is arranged at above-mentioned dynamic
In the blood circuit of arteries and veins side, and it can carry out：In blood purification treatment along blood circulation direction drive forward drive and
Along the reverse drive of the direction driving in opposite direction with blood circulation during blood purification treatment；Priming fluid supply pipeline, this is pre-
Topping up supply pipeline is connected with above-mentioned blood circuit, and priming fluid can be supplied to the inside of the blood circuit；Priming fluid discharge unit,
The priming fluid discharge unit can make the priming fluid supplied by above-mentioned priming fluid supply pipeline from blood circuit overflow, be discharged to outer
Portion；1st valve system, the 1st valve system can be closed arbitrarily or open above-mentioned priming fluid supply pipeline；2nd valve system, the 2nd
Valve system can be closed arbitrarily or open above-mentioned priming fluid discharge unit；Controlling organization, the controlling organization can control above-mentioned blood pump,
1st valve system and the 2nd valve system；In the apparatus for purifying blood, it is in the blood introducing port of above-mentioned blood purification mechanism
State upward carries out preliminary filling, it is characterised in that above-mentioned controlling organization carries out following steps of exhausting, in the steps of exhausting
In, in preliminary filling, above-mentioned blood pump is carried out reverse drive, and by above-mentioned priming fluid discharge unit and above-mentioned priming fluid supply pipe
Line is opened, while priming fluid is supplied from the priming fluid supply pipeline, while discharging priming fluid from above-mentioned priming fluid discharge unit.
Invention described in claim 2 is related to the apparatus for purifying blood described in claim 1, it is characterised in that above-mentioned
Between above-mentioned blood pump and blood purification mechanism in arterial side blood circuit, arterial side air pocket room is connected.
Invention described in claim 3 is related to the apparatus for purifying blood described in claim 1 or 2, it is characterised in that upper
State and venous side air pocket room is connected on venous side blood circuit, and above-mentioned priming fluid discharge unit is by from the upper of the venous side air pocket room
The extended overflow line in portion is constituted.
Invention described in claim 4 is related to a kind of method for pre-charging of apparatus for purifying blood, and the apparatus for purifying blood includes：
Blood circuit, the blood circuit is made up of arterial side blood circuit and venous side blood circuit, and can by the blood of patient from
The front end extracorporal circulatory system of the arterial side blood circuit is to the front end of venous side blood circuit；Blood purification mechanism, the blood purification
Mechanism is situated between the arterial side blood circuit and venous side blood circuit of the blood circuit, the blood to flowing through the blood circuit
Liquid is purified, and formed via the membrane for purifying blood purified to blood make the blood pathway that the blood of patient flows through with
And the dialysate circuit for flowing through dialyzate, the blood purification mechanism is led with the blood that can be imported blood in the blood pathway
Entrance, can by blood derived from the blood pathway blood export mouth, dialyzate can be imported it is saturating in above-mentioned dialysate circuit
Analyse liquid introducing port and can by dialyzate derived from the dialysate circuit dialyzate export mouth；Blood pump, the blood pump is set
In above-mentioned arterial side blood circuit, and it can carry out：The forward direction driven in blood purification treatment along the direction of blood circulation
Driving and the reverse drive in blood purification treatment along the direction driving in opposite direction with blood circulation；Priming fluid supply pipe
Line, the priming fluid supply pipeline is connected with above-mentioned blood circuit, and priming fluid can be supplied to the inside of the blood circuit；Priming fluid
Discharge unit, the priming fluid discharge unit can make the priming fluid supplied by above-mentioned priming fluid supply pipeline from blood circuit overflow,
It is discharged to outside；1st valve system, the 1st valve system can be closed arbitrarily or open above-mentioned priming fluid supply pipeline；2nd valve system,
2nd valve system can be closed arbitrarily or open above-mentioned priming fluid discharge unit, in the method for pre-charging of the apparatus for purifying blood,
The state that the blood introducing port of above-mentioned blood purification mechanism is in upward carries out preliminary filling, it is characterised in that carry out following rows
Jia bombardier is rapid, in the steps of exhausting, in preliminary filling, above-mentioned blood pump is carried out reverse drive, and above-mentioned priming fluid is discharged
Portion and above-mentioned priming fluid supply pipeline are opened, while supply priming fluid from the priming fluid supply pipeline, while from above-mentioned priming fluid
Discharge unit discharges priming fluid.
Invention described in claim 5 is related to the method for pre-charging of the apparatus for purifying blood described in claim 4, and its feature exists
In, between the above-mentioned blood pump and blood purification mechanism in above-mentioned arterial side blood circuit, connection arterial side air pocket room.
Invention described in claim 6 is related to the method for pre-charging of the apparatus for purifying blood described in claim 4 or 5, and it is special
Levy and be, connect venous side air pocket room on above-mentioned venous side blood circuit, and above-mentioned priming fluid discharge unit is by from the vein
The extended overflow line in the top of side air pocket room is constituted.
The effect of invention
According to the invention described in claim 1,4, due to carrying out following steps of exhausting, in the steps of exhausting, in preliminary filling
When, make above-mentioned blood pump reverse drive, and priming fluid discharge unit and above-mentioned priming fluid supply pipeline are opened, while pre- from this
Topping up supply pipeline supplies priming fluid, while priming fluid is discharged from the priming fluid discharge unit, therefore can be while behaviour when maintaining preliminary filling
The property made, the bubble that blood purification mechanism is positively carried out on one side is eliminated.
According to the invention described in claim 2,5, because the blood pump and blood in above-mentioned arterial side blood circuit are net
Change connection arterial side air pocket room between mechanism, therefore the blood for retaining in blood purification mechanism can be received by the arterial side air pocket room
The bubble of liquid introducing port vicinity, and the bubble that exceedingly flows into the arterial side air pocket room can be made, together with priming fluid from
Priming fluid discharge unit is discharged.
According to the invention described in claim 3,6, due to connecting venous side air pocket room on venous side blood circuit, and
Above-mentioned priming fluid discharge unit is made up of the extended overflow line in the top from the venous side air pocket room, therefore can be borrowed with general
Mode is arranged at venous side air pocket room and overflow line in blood circuit, and the priming fluid supplied from priming fluid supply pipeline is arranged
Go out to outside.
Brief description of the drawings
Fig. 1 is the signal for the apparatus for purifying blood (state for being mounted with puncture needle) for representing the 1st embodiment of the present invention
Figure；
Fig. 2 is the schematic diagram of the state (bleed steps) when representing the preliminary filling of the apparatus for purifying blood；
Fig. 3 is the schematic diagram of the state (circulation step) when representing the preliminary filling of the apparatus for purifying blood；
Fig. 4 is the schematic diagram of the state (cleaning step) when representing the preliminary filling of the apparatus for purifying blood；
Fig. 5 is the schematic diagram of the state (steps of exhausting) when representing the preliminary filling of the apparatus for purifying blood；
Fig. 6 is the flow chart of control content when representing the preliminary filling of the apparatus for purifying blood；
The flow chart of control content when Fig. 7 is the preliminary filling for the apparatus for purifying blood for representing the 2nd embodiment of the present invention；
For the apparatus for purifying blood of the 3rd embodiment that represents the present invention, (liquid before preliminary filling retains forming step to Fig. 8
When, the state of blood pump forward drive) schematic diagram；
Fig. 9 for represent the apparatus for purifying blood (when the liquid before preliminary filling retains forming step, blood pump reverse drive
State) schematic diagram；
Figure 10 is the schematic diagram of the state (cleaning step) when representing the preliminary filling of the apparatus for purifying blood；
Figure 11 is the schematic diagram of the state (cleaning step) when representing the preliminary filling of the apparatus for purifying blood；
Figure 12 is the schematic diagram of the state (steps of exhausting) when representing the preliminary filling of the apparatus for purifying blood；
Figure 13 is the flow that the liquid for the apparatus for purifying blood for representing the embodiment retains the control content of forming step
Figure；
For the apparatus for purifying blood of the 4th embodiment that represents the present invention, (liquid before preliminary filling retains to form step Figure 14
When rapid, the state of blood pump reverse drive) schematic diagram.
Embodiment
With reference to the accompanying drawings, embodiments of the present invention are specifically described.
The apparatus for purifying blood of 1st embodiment is made up of the dialysis apparatus for carrying out dialysis treatment, the blood purification
Device is as shown in figure 1, mainly include：The blood circuit being made up of arterial side blood circuit 1 and venous side blood circuit 2；Jie sets
Between arterial side blood circuit 1 and venous side blood circuit 2, the dialyzer 3 purified to the blood for flowing through blood circuit
(blood purification mechanism)；The blood pump 4 for the extrusion pressing type being arranged in arterial side blood circuit 1；It is connected with arterial side blood circuit 1
Arterial side air pocket room 5；The venous side air pocket room 6 being connected with venous side blood circuit 2；Priming fluid supply pipeline Lc；As pre-
The overflow line L of topping up discharge unit；It is used as the magnetic valve V6 of the 1st valve system；It is used as the magnetic valve V3 of the 2nd valve system；Control machine
Structure 11.
In arterial side blood circuit 1, arterial side puncture needle a is connected via connector c in its front end, and wherein
Way is provided with the blood pump 4 of extrusion pressing type.The blood pump 4 can carry out making blood drive to the direction of circulation in blood purification treatment
Forward drive (driving of the anticlockwise in Fig. 1) and make blood in blood purification treatment to the side in opposite direction with circulation
To the reverse drive (driving of the right rotation in Fig. 1) of driving.In addition, blood pump 4 and dialysis in arterial side blood circuit 1
Between device 3, arterial side air pocket room 5 is connected with, de-bubble processing can be carried out to the liquid for flowing through arterial side blood liquid loop 1.
On the other hand, in venous side blood circuit 2, venous side puncture needle b is connected via connector d in its front end,
And it is connected with venous side air pocket room 6 on the way wherein, de-bubble processing can be carried out to the liquid for flowing through venous side blood circuit 2.From
The top (air layer side) of the venous side air pocket room 6, being extended has overflow line L (priming fluid discharge unit), from venous side gas
The liquid of overflow is discharged to outside in trap room 6.In addition, in overflow line L, the magnetic valve V3 as the 2nd valve system is provided with,
Magnetic valve V3 can be closed arbitrarily or the open stream.
In addition, if in the state of being punctured using arterial side puncture needle a and venous side puncture needle b to patient, making
Blood pump 4 carries out forward drive, then the blood of patient is while by the de-bubble of arterial side air pocket room 5, while passing through arterial side blood
Loop 1 reaches dialyzer 3, then carries out blood purification by the dialyzer 3, while passing through the de-bubble of venous side air pocket room 6, one side
The internal of patient is returned to by venous side blood circuit 2.Thus, while making the blood of patient from the arterial side blood of blood circuit
The front end extracorporal circulatory system in liquid loop 1 is to the front end of venous side blood circuit 2, while being purified by dialyzer 3.
On dialyzer 3, it is formed with its housing department：Blood introducing port 3a (blood importing port), blood export mouth
3b (blood export port), dialyzate introducing port 3c (dialysate circuit entrances：Dialyzate imports port) and dialyzate export
(dialysate circuit is exported mouth 3d：Dialyzate exports port).Wherein, the base of blood introducing port 3a connection arterial sides blood circuit 1
End, the cardinal extremity of blood export mouth 3b connection venous sides blood circuit 2.In addition, dialyzate introducing port 3c and dialyzate export mouth 3d
Pipeline La and dialyzate discharge pipe Lb is imported with the dialyzate being extended from dialysis apparatus main body respectively to be connected.
There are multiple macaroni yarns (being not shown in figure) in the internal admission of dialyzer 3, the macaroni yarn is constituted for blood
The membrane for purifying blood that liquid is purified.In addition, being internally formed in dialyzer 3：Make the blood of patient via membrane for purifying blood
The blood pathway (being located at the stream between the blood introducing port 3a and blood export mouth 3b of the inner space of hollow fiber membrane) flowed through；
The dialysate circuit for flowing through dialyzate (is located at the dialyzate introducing port 3c and dialyzate export mouth of the exterior space of hollow fiber membrane
Stream between 3d).
That is, dialyzer 3 includes：The blood introducing port 3a that blood can be imported in blood pathway；Can be by blood from the blood
Blood export mouth 3b derived from stream；Dialyzate can be directed into the dialyzate introducing port 3c in dialysate circuit；And can be by
Dialyzate derived dialyzate export mouth 3d from the dialysate circuit, and constitute in such a way：From blood introducing port 3a
Blood export mouth 3b blood is flowed to, with flowing to dialyzate export mouth 3d dialyzate from dialyzate introducing port 3c in reverse.Separately
Outside, constitute in the following manner：Multiple small holes are formed in the macaroni yarn for constituting membrane for purifying blood, the hole passes through macaroni yarn
Outer peripheral face and inner peripheral surface, formed hollow fiber membrane, via the film, impurity in blood etc. can pass through to the inside of dialyzate.
Dual pump 9 imports pipeline La and dialyzate discharge pipe Lb in the inside of dialysis apparatus main body according to across dialyzate
Mode set, and be provided with the dialysis apparatus main body except water pump 10, should be used to flow from dialyzer 3 except water pump 10
Moisture removal is removed in the blood of dynamic patient.One end that dialyzate imports pipeline La is connected with dialyzer 3 (dialyzate introducing port 3c),
And its other end is connected with the dialysate supply unit (not shown in FIG.) of the dialyzate of modulation specifications concentration.In addition, thoroughly
Analysis liquid discharge pipe Lb one end is connected with dialyzer 3 (dialyzate export mouth 3d), and its other end and not shown in figure
Drainage mechanism connection.In addition, the dialyzate supplied from dialysate supply unit imports pipeline La by dialyzate and reaches dialysis
Device 3, is flowed through after dialysate circuit, and drainage mechanism is sent to by dialyzate discharge pipe Lb.
The midway (between dual pump 9 and dialyzer 3) for importing pipeline La in dialyzate be connected with the stream can be closed and
Open magnetic valve V4, and be connected with dialyzate discharge pipe Lb midway (between dual pump 9 and dialyzer 3) can be any
Ground closes the stream or open magnetic valve V5.In addition, in the front (near connector c) of arterial side blood circuit 1 and
The front (near connector d) of venous side blood circuit 2, is connected with the magnetic valve that arbitrarily stream can be closed and opened
V1 and V2.In addition, in the front of arterial side blood circuit 1, the bubble being provided with the detectable liquid for flowing through the position
Arterial side bubble testing agency 7, and in the front of venous side blood circuit 2, it is provided with the detectable liquid for flowing through the position
The venous side bubble testing agency 8 of bubble in body.
In priming fluid supply pipeline Lc, its front end and blood circuit (magnetic valve V1 and blood in arterial side blood circuit 1
Connecting portion P between liquid pump 4) connection, priming fluid (dialyzate) can be supplied to inside the blood circuit, in present embodiment
In, its cardinal extremity and dialyzate are imported between the dual pump 9 in pipeline La and magnetic valve V4 and connected.In addition, in priming fluid supply pipe
Line Lc midway, is provided with the magnetic valve V6 as the 1st valve system, and the stream arbitrarily can be closed or opened by magnetic valve V6
Put.
In addition, constituting in the following manner, which is：While being closed magnetic valve V4, while making electromagnetism
Valve V6 is in open mode, and drives dual pump 9, thus, and the dialyzate that dialyzate imports pipeline La is supplied via priming fluid
Pipeline Lc is supplied to blood circuit.Thus, in the present embodiment, flowing through dialyzate and importing pipeline La dialyzate as preliminary filling
Liquid, is supplied to blood circuit (arterial side blood circuit 1).
In controlling organization 11 and this apparatus for purifying blood include blood pump 4, dual pump 9, magnetic valve V1~V6 each
Structure member is electrically connected, and the controlling organization 11 can control these structure members, and controlling organization 11 is by being such as arranged at dialysis apparatus
Microcomputer in main body etc. is constituted.In addition, constituting in such a way：Preliminary filling before the treatment, blood purification treatment, control
After treatment when returning blood, act by controlling organization 11 arbitrary structure member.In addition, controlling organization 11 also can ad hoc enter
Control during row preliminary filling.
But, preliminary filling before the treatment (priming fluid is cleaned by blood circuit, blood pathway of dialyzer 3 etc.,
It is pre-filled with the operation of the priming fluid) when, the front end of arterial side blood circuit 1 and the front end of venous side blood circuit 2 can be connected
Connect and (specifically, by connector c and connector d connections, stream is interconnected).
Herein, the apparatus for purifying blood of present embodiment carries out following steps of exhausting, in this step, passes through control
The control of mechanism 11, in preliminary filling, as shown in figure 5, make blood pump 4 carry out reverse drive, and make magnetic valve V3, V6 be in beat
Open state, overflow line L (priming fluid discharge unit) and priming fluid supply pipeline Lc are opened, while from the priming fluid supply pipeline
Lc supply priming fluids (dialyzate), while discharging priming fluid (dialyzate) from overflow line L.
Below according to Fig. 6 flow chart, the preliminary filling that the apparatus for purifying blood by present embodiment is carried out is illustrated.
In preliminary filling, as shown in Fig. 2 the blood introducing port 3a of dialyzer 3 is in state upward (by figure
Unshowned fixed mechanism and fix), and by connector c and connector d connections, stream is interconnected, then, pass through control
Mechanism 11 processed, makes magnetic valve V1, V2, V3, V6 be in open mode, and is closed magnetic valve V4, V5, and leads to
Crossing drives dual pump 9, carries out bleed steps S1.
In bleed steps S1, blood pump 4 is set to be in the state stopped, the preliminary filling supplied from priming fluid supply pipeline Lc
Liquid (dialyzate) is from the connecting portion P of arterial side blood circuit 1 towards the leading section of the arterial side blood circuit 1 and venous side blood
In the leading section flowing in loop 2, the venous side air pocket room 6 for flowing into venous side blood circuit 2, and from the venous side air pocket room 6
The priming fluid (dialyzate) of middle overflow is discharged to outside by overflow line L.
In addition, in step S2, judging whether have passed through the stipulated time from being started bleed steps S1, when have passed through regulation
Between occasion, be circulated step S3.In addition, in bleed steps S1, in arterial side bubble testing agency 7 or venous side bubble
Testing agency 8 does not detect the occasion of bubble in the stipulated time, can be circulated step S3 yet.Circulation step S3 is under
The mode of stating is carried out：As shown in figure 3, by controlling organization 11 make magnetic valve V1, V2 be in open mode, and make magnetic valve V3,
V4, V5, V6 are closed, and reverse drive blood pump 4.Thus, the priming fluid (dialysis supplied by bleed steps S1
Liquid) circulate and flow in the blood pathway of arterial side blood circuit 1, venous side blood circuit 2 and dialyzer 3.
Then, in step S4, judge whether arterial side bubble testing agency 7 detects bubble, if detecting bubble,
Step S1 is then returned to, bleed steps are carried out again.Thus, not detecting bubble by arterial side bubble testing agency 7
Before, bleed steps S1 and circulation step S3, arterial side blood circuit 1, venous side blood circuit 2 and dialyzer is repeated
The stream of 3 blood pathway is replaced into priming fluid (dialyzate) (being filled by priming fluid) from air.In addition, also can be in step
S4, judges whether venous side bubble testing agency 8 detects bubble.
On the other hand, if judging not detect bubble in step S4, dialyzate filling step S5 is carried out.This is saturating
Analysis liquid filling step S5 is referred to as so-called gas purging steps, in this step, is at least in magnetic valve V3, V6 and closes shape
State, makes magnetic valve V4, V5 be in open mode in addition, and by driving dual pump 9, dialyzate is full of the dialyzate stream of dialyzer 3
Lu Zhong.In addition, in dialyzate filling step S5, other magnetic valve V1, V2 can also be in open mode, closed mode
Any one, can also make blood pump 4 be in operating state, halted state in any one.
Then, in step S6, whether the stipulated time is have passed through after judging since the dialyzate filling step S5, have passed through
The occasion of stipulated time, into cleaning step S7.Cleaning step S7 is carried out by following manner：As shown in figure 4, passing through control
Mechanism 11, makes magnetic valve V1~V3, V6 be in open mode, is in addition closed magnetic valve V4, V5, and to blood
Pump 4 carries out forward drive.Now, the actuating speed of blood pump 4 is according to less than the priming fluid supplied from priming fluid supply pipeline Lc
The mode of the flow of (dialyzate) is set, and the priming fluid from priming fluid supply pipeline Lc supplies is in arterial side blood circuit 1
Flowed in both front (connector c sides) and the side of blood pump 4.
Thus, relative to the blood circuit that priming fluid (dialyzate) is filled with bleed steps S1 and circulation step S3,
Priming fluid (dialyzate) is further supplied from priming fluid supply pipeline Lc, branch road is formed from connecting portion P to both direction and flows,
Outside is discharged to from overflow line L, therefore the blood pathway of blood circuit and dialyzer 3 can be cleaned.Then, in step S8,
Judge whether reached ormal weight from the priming fluid that priming fluid supply pipeline Lc is supplied, reaching the occasion of ormal weight, carrying out
Steps of exhausting S9.
Above-mentioned steps of exhausting S9 is carried out by following manner：As shown in figure 5, by controlling organization 11 make magnetic valve V1~
V3, V6 are in open mode, make magnetic valve V4, V5 be closed (that is, from cleaning step S7, maintaining magnetic valve in addition
V1~V6 state), and reverse drive is carried out to blood pump 4.That is, reverse drive is carried out to blood pump 4, and opens overflow
Pipeline L (priming fluid discharge unit) and priming fluid supply pipeline Lc, while (being dialysed from priming fluid supply pipeline Lc supply priming fluids
Liquid), while discharging priming fluid (dialyzate) from overflow line L (priming fluid discharge unit).
Now, the actuating speed of blood pump 4 is according to less than the priming fluid (dialyzate) supplied from priming fluid supply pipeline Lc
The mode of flow set, supplying cocurrent from priming fluid supply pipeline Lc enters priming fluid in venous side air pocket room 6 in dialysis
Flowed in both the side of device 3 and overflow line L sides.That is, while priming fluid is supplied in blood circuit, circulate it, on one side
It is discharged in overflow line L.By like this, carrying out reverse drive to blood pump 4, making from priming fluid supply pipeline Lc's
The supply of priming fluid and the discharge of relative overflow line L priming fluid are carried out simultaneously, can import the blood for being stranded in dialyzer 3
The bubble of mouthful 3a side is moved in arterial side air pocket room 5, can also be by the reverse drive of blood pump 4, by arterial side air pocket room 5
The air in portion is moved in venous side air pocket room 6, it can be discharged into outside via overflow line L.
Then, in step S10, judge the priming fluid of ormal weight whether has been supplied from priming fluid supply pipeline Lc, or from row
The rapid S9 of jia bombardier has started whether to have passed through the stipulated time, in the occasion for the priming fluid for having supplied ormal weight, or when have passed through regulation
Between occasion, terminate a series of step related to preliminary filling.In addition, also arterial side bubble detection machine can be judged in step S10
Whether structure 7 or venous side bubble testing agency 8 detect bubble, in the venous side bubble testing agency 7 or arterial side bubble
Testing agency 8 does not detect the occasion of bubble, can terminate a series of step related to preliminary filling yet.In addition, after preliminary filling,
The connection of the front end of arterial side blood circuit 1 and the front end of venous side blood circuit 2 is released, installs dynamic in respective front end respectively
Arteries and veins side puncture needle a and venous side puncture needle b, is punctured in patient, thus, the step of can starting blood purification treatment.
Below according to Fig. 7 flow chart, the preliminary filling of the apparatus for purifying blood of the 2nd embodiment of the present invention is said
It is bright.It is identical with the 1st embodiment on the structure of blood circuit, dialyzer, dialysis apparatus main body etc., omit saying to them
It is bright.
Identical with the 1st embodiment in preliminary filling, the states of the blood introducing port 3a in dialyzer 3 upward are (logical
Cross the fixed mechanism not shown in figure and fix), and by connector c and connector d connections, stream is set to mutual in advance
The state of connection.If start preliminary filling, first carry out bleed steps S1 (reference picture 2), and in step S2 determine whether through
The stipulated time has been spent, the occasion of stipulated time is being have passed through, step S3 (reference picture 5) has been exhausted.
Then, judge whether arterial side bubble testing agency 7 detects bubble in step S4, if detecting bubble,
Step S1 is then returned to, bleed steps are carried out again.In addition, also venous side bubble testing agency 8 can be judged whether in step S4
Detect bubble.Like this, overflow step can be repeated untill arterial side bubble testing agency 7 does not detect bubble
Rapid S1 and steps of exhausting S3, the bubble that will be stranded in the blood introducing port 3a sides of dialyzer 3 is moved in arterial side air pocket room 5,
By the reverse drive of blood pump 4 air in arterial side air pocket room 5 can be made to be moved in venous side air pocket room 6 in addition, via
Overflow line L is discharged to outside.
On the other hand, if judging not detect bubble in step S4, dialyse with the 1st embodiment identical
Liquid filling step S5.Then, judge whether have passed through the stipulated time since dialyzate filling step S5 in step S6, passing through
The occasion of stipulated time, into cleaning step S7 (reference picture 4).Then, judge in step S8 from priming fluid supply pipeline Lc
Whether the priming fluid of supply reaches ormal weight, is reaching the occasion of ormal weight, is terminating a series of step related to preliminary filling
Suddenly.
The apparatus for purifying blood of the 3rd embodiment of the present invention is illustrated below.
The apparatus for purifying blood of present embodiment is identical with the 1st embodiment, is filled by the dialysis for carrying out dialysis treatment
Composition is put, as shown in Fig. 8~12, is mainly made up of following part：By arterial side blood circuit 1 and the structure of venous side blood circuit 2
Into blood circuit；It is situated between and is located between arterial side blood circuit 1 and venous side blood circuit 2, the blood to flowing through blood circuit
The dialyzer 3 (blood purification mechanism) purified；The blood pump 4 for the extrusion pressing type being arranged in arterial side blood circuit 1；With moving
The arterial side air pocket room 5 that arteries and veins side blood circuit 1 is connected；The venous side air pocket room 6 being connected with venous side blood circuit 2；Priming fluid
Supply pipeline Ld；It is used as the overflow line L of priming fluid discharge unit；It is used as the magnetic valve V6 of the 1st valve system；It is used as the 2nd valve system
Magnetic valve V3；Controlling organization 11.In addition, for the 1st embodiment identical element, using same label, omit
Their description.
In priming fluid supply pipeline Ld, its front end and blood circuit (magnetic valve V1 and blood in arterial side blood circuit 1
Connecting portion P between liquid pump 4) connection, priming fluid (physiological saline) can be supplied to inside the blood circuit, in present embodiment
In, its cardinal extremity is connected with receiving mechanism 12 (mechanism of referred to as so-called " normal saline bag ").In addition, in priming fluid supply pipeline
Ld midway, is provided with the magnetic valve V6 as the 1st valve system, connects priming fluid air pocket room 13, magnetic valve V6 can be any
Ground closes the stream or open.
Receive mechanism 12 to be made up of flexible transparent container, physiological saline (priming fluid) can be accommodated by ormal weight, this connects
Receiving mechanism 12 is installed on the front end of the hole (not shown in FIG.) being such as based in dialysis apparatus main body.Also, by making electricity
Magnet valve V6 is in open state, and the stream is opened, and receives the physiological saline in mechanism 12 to be supplied to blood circuit because of deadweight.
In addition, by priming fluid air pocket room 13, can visual physiological saline (priming fluid) supply (dripping).
Herein, in the present embodiment, before preliminary filling, the relative priming fluid carried out as shown in Figure 13 uses air pocket room
13 liquid retains forming step, then carries out preliminary filling.
First, as shown in figure 8, the blood introducing port 3a of dialyzer 3 is in state upward (by not showing in figure
The fixed mechanism that goes out and fix), and by connector c and connector d connections, make mutual fluid communication, then, pass through control
Mechanism 11 makes magnetic valve V2, V6 be in open mode, and is closed magnetic valve V1, V3~V5, and by just
To driving blood pump 4, carry out liquid and retain forming step Sa.Thus, mechanism 12 will can be received via priming fluid supply pipeline Ld
Interior physiological saline (priming fluid) imported into the connecting portion P of arterial side blood circuit 1.
Then, in step Sb, judge whether blood pump 4 carries out forward drive with specified quantity (such as 5 circle), if reached
The number of turns is provided, then carries out liquid and retains forming step Sc.The liquid, which accumulates, stays forming step Sc for following steps, wherein, such as
Shown in Fig. 9, by controlling organization 11, magnetic valve V2, V6 is set to be in open mode, and magnetic valve V1, V3~V5 is in pass
Closed state (maintains liquid to retain forming step Sb state), and blood pump 4 is carried out reverse drive.Thus, in priming fluid
The liquid for producing physiological saline with the inside of air pocket room 13 is retained.
The apparatus for purifying blood of present embodiment is retained after forming step terminates in aforesaid liquid, carries out the 1st embodiment
Preliminary filling (reference picture 6) or the 2nd embodiment preliminary filling (reference picture 7).But, in the occasion of present embodiment, in cleaning step
In rapid, as shown in Figure 10, by controlling organization 11, magnetic valve V1~V3, V6 is in open mode, and make magnetic valve V4,
V5 is closed, and after blood pump 4 is stopped, as shown in figure 11, magnetic valve V3, V6 is in open mode, and
Magnetic valve V1, V2, V4, V5 are closed, and forward drive blood pump 4.In addition, magnetic valve V1, V2 can also be in
Open mode.
In addition, the steps of exhausting of present embodiment is carried out by following manner：As shown in figure 12, by controlling organization 11,
Magnetic valve V1~V3, V6 is in open mode, and be closed magnetic valve V4, V5, and reverse drive blood
Pump 4.By the steps of exhausting, while carrying out the supply of the priming fluid from priming fluid supply pipeline Ld and from overflow line L
Priming fluid discharge, thus, the bubble for the blood introducing port 3a sides for retaining in dialyzer 3 can be made to be moved to arterial side air pocket room
In 5, the air inside arterial side air pocket room 5 can be moved to by venous side air pocket room 6 by the reverse drive of blood pump 4 in addition
In, it is discharged to outside via overflow line L.
The apparatus for purifying blood of the 4th embodiment of the present invention is illustrated below.
The apparatus for purifying blood of present embodiment is identical with the 1st embodiment, is filled by the dialysis for carrying out dialysis treatment
Composition is put, as shown in figure 14, is mainly made up of following part：It is made up of arterial side blood circuit 1 and venous side blood circuit 2
Blood circuit；It is situated between and is located between arterial side blood circuit 1 and venous side blood circuit 2, the blood for flowing through blood circuit 1 is carried out
The dialyzer 3 (blood purification mechanism) of purification；The blood pump 4 for the extrusion pressing type being arranged in arterial side blood circuit 1；With arterial side
The arterial side air pocket room 5 that blood circuit 1 is connected；The venous side air pocket room 6 being connected with venous side blood circuit 2；Priming fluid is supplied
Pipeline Le；It is used as the overflow line L of priming fluid discharge unit；It is used as the magnetic valve V6 of the 1st valve system；It is used as the electricity of the 2nd valve system
Magnet valve V3；Controlling organization 11.In addition, for the 1st embodiment identical element, using same label, omit to it
Explanation.
In priming fluid supply pipeline Le, its front end and blood circuit (magnetic valve V2 in venous side blood circuit 2 and quiet
Connecting portion P between arteries and veins side air pocket room 6) connection, priming fluid (dialyzate) can be supplied to inside the blood circuit, in this implementation
In mode, its cardinal extremity and dialyzate are imported and connected between pipeline La dual pump 9 and magnetic valve V4.In addition, in priming fluid supply
Pipeline Le midway, is provided as the magnetic valve V6 of the 1st valve system, and the stream arbitrarily can be closed or opened by magnetic valve V6
Put.
Moreover, being closed magnetic valve V4 by one side, while making magnetic valve V6 be in open mode, and drive
Dynamic dual pump 9, dialyzate imports pipeline La dialyzate via priming fluid supply pipeline Le, is supplied to venous side blood circuit 2.
Thus, in the present embodiment, flowing through priming fluid supply pipeline Le dialyzate, that blood circuit is supplied to as priming fluid is (quiet
Arteries and veins side blood circuit 2).
Herein, the apparatus for purifying blood of present embodiment carries out the preliminary filling (reference picture 6) or the 2nd of the 1st embodiment in fact
Apply the preliminary filling (reference picture 7) of mode.But, in the occasion of present embodiment, in steps of exhausting, as shown in figure 14, arterial side
The front end of blood circuit 1 and the front end of venous side blood circuit 2 are not connected, and in the state opened up to each other, pass through control machine
Structure 11, makes magnetic valve V1, V2, V6 be in open mode, and is closed magnetic valve V3~V5, and reverse drive
Blood pump 4.Now, the actuating speed of blood pump 4 is according to less than the priming fluid (dialyzate) supplied from priming fluid supply pipeline Le
The mode of flow set, the priming fluid supplied from priming fluid supply pipeline Le is in the side of dialyzer 3 and venous side blood circuit 2
Both middle flowing of front (connector d sides).
By the steps of exhausting, the priming fluid from priming fluid supply pipeline Le supply with from the pre- of overflow line L
The discharge of topping up is carried out simultaneously, thus, and the bubble for the blood introducing port 3a sides that can will retain in dialyzer 3 is moved to arterial side gas
In trap room 5, the air inside arterial side air pocket room 5 can be moved to by arterial side blood by the reverse drive of blood pump 4 in addition
The front (connector c sides) in loop 1, is thus discharged to outside.In addition, can also constitute in the following manner：By making magnetic valve
V3 is in open mode, from priming fluid supply pipeline Le supply streams enter priming fluid in venous side air pocket room 6 in the side of dialyzer 3 and
Flowed in both overflow line L sides.In the occasion, by the reverse drive of blood pump 4 air can be made to be moved to venous side gas
Trap room 6, outside is discharged to via overflow line L.
According to above-mentioned 1st~4 embodiment, due to carrying out following steps of exhausting, in this step, in preliminary filling, instead
To driving blood pump 4, and overflow line L (priming fluid discharge unit) and priming fluid supply pipeline (Lc, Ld, Le) is open, one
While priming fluid is supplied from the priming fluid supply pipeline (Lc, Ld, Le), while pre- from overflow line L (priming fluid discharge unit) discharges
Topping up, therefore can be while operability when maintaining preliminary filling, the bubble row that dialyzer 3 (blood purification mechanism) is positively carried out on one side
Go out.
In addition, according to above-mentioned 1st~4 embodiment, due to the blood in arterial side air pocket room 5 and arterial side blood circuit 1
Connected between liquid pump 4 and dialyzer 3 (blood purification mechanism), therefore can make to retain near the blood introducing port 3a of dialyzer 3
Bubble is received in the arterial side air pocket room 5, and the bubble and priming fluid that will can exceedingly flow into the arterial side air pocket room 5
Discharged together from overflow line L (priming fluid discharge unit).
In addition, according to above-mentioned 1st~4 embodiment, due to connecting venous side air pocket room 6 in venous side blood circuit 2,
And priming fluid discharge unit is made up of the extended overflow line L in the top from the venous side air pocket room 6, therefore can be borrowed with logical
Venous side air pocket room 6 and overflow line L in blood circuit are arranged at mode, will be from priming fluid supply pipeline (Lc, Ld, Le)
The priming fluid of supply is discharged to the outside.
Further, according to above-mentioned 1st~4 embodiment, due in whole priming procedures, being led in the blood of dialyzer 3
Entrance 3a upward in the state of carry out, therefore do not need the dialyzer 3 reverse turn operation up and down, can easily make priming procedure
Automation, and the discharge of the quick and certain bubble in dialyzer 3 can be carried out.In addition, according to above-mentioned 1st~4 embodiment party
Formula, due to that can carry out preliminary filling operation by a series of control of controlling organization 11, therefore can easily seek the automation of preliminary filling,
The operation of operating personnel can be significantly decreased.Further, since this implementation can be carried out by changing the control content of controlling organization 11
Mode is such to be acted, therefore borrowing as former state substantially includes the apparatus for purifying blood of existing blood circuit, forms the present invention's
Apparatus for purifying blood (dialysis apparatus).
Present embodiment is illustrated above, but the present invention is not limited thereto, such as, be applicable to without dynamic
Arteries and veins side air pocket room 5 or the occasion of venous side air pocket room 6.In addition, if the priming fluid that will can be supplied by priming fluid supply pipeline
(dialyzate or physiological saline) is discharged to outside from blood circuit overflow, then can also replace overflow line L, and composition is formed at other
The position (priming fluid discharge unit) of position.In addition, the priming fluid supplied by priming fluid supply pipeline be not limited to dialyzate or
Physiological saline, can also use other liquid.In addition, in the present embodiment, it is adaptable to the dialysis apparatus of the occasion of dialysis treatment,
But be equally applicable to while making the blood extracorporeal circulation of patient, while the other devices purified to it are (such as using blood mistake
Filter dialysis, blood filtration method, AFBF apparatus for purifying blood, plasma adsorption device etc.).
Utilization possibility in industry
If following apparatus for purifying blood and its method for pre-charging, then the field of other forms and purposes is equally applicable to
Close, in the apparatus for purifying blood and its method for pre-charging, carry out following steps of exhausting：In preliminary filling, enter above-mentioned blood pump
Row reverse drive, and above-mentioned priming fluid discharge unit and above-mentioned priming fluid supply pipeline are opened, while being supplied from the priming fluid
Pipeline supplies priming fluid, while discharging priming fluid from the priming fluid discharge unit.
The explanation of label：
Label 1 represents arterial side blood circuit；
Label 2 represents venous side blood circuit；
Label 3 represents dialyzer (blood purification mechanism)；
Label 4 represents blood pump；
Label 5 represents arterial side air pocket room；
Label 6 represents venous side air pocket room；
Label 7 represents arterial side bubble testing agency；
Label 8 represents venous side bubble testing agency；
Label 9 represents dual pump；
Label 10 represents to remove water pump；
Label 11 represents controlling organization；
Label 12 represents to receive mechanism；
Label 13 represents that priming fluid uses air pocket room；
Symbol La represents that dialyzate imports pipeline；
Symbol Lb represents dialyzate discharge pipe；
Symbol Lc, Ld, Le represent priming fluid supply pipeline；
Symbol L represents overflow line (priming fluid discharge unit)；
Symbol V3 represents magnetic valve (the 2nd valve system)；
Symbol V6 represents magnetic valve (the 1st valve system).
Claims (4)
1. a kind of apparatus for purifying blood, the apparatus for purifying blood includes：
Blood circuit, the blood circuit is made up of arterial side blood circuit and venous side blood circuit, and can be by the blood of patient
Liquid is from the front end extracorporal circulatory system of the arterial side blood circuit to the front end of venous side blood circuit；
Blood purification mechanism, the blood purification mechanism is situated between located at the arterial side blood circuit and venous side blood time of the blood circuit
Between road, the blood for flowing through the blood circuit is purified, and formed via the membrane for purifying blood purified to blood
Make the blood pathway that the blood of patient flows through and the dialysate circuit for flowing through dialyzate, the blood purification mechanism has can be by
Blood introducing port that blood is imported in the blood pathway, can by blood derived from the blood pathway blood export mouth, can will be thoroughly
Dialyzate introducing port and dialyzate can be dialysed derived from the dialysate circuit that analysis liquid is imported in above-mentioned dialysate circuit
Liquid export mouth；
Blood pump, the blood pump is arranged in above-mentioned arterial side blood circuit, and can be carried out：In blood purification treatment along blood
Forward drive and edge and the direction in opposite direction of blood circulation drive in blood purification treatment that the direction of liquid circulation drives
Reverse drive；
Priming fluid supply pipeline, the priming fluid supply pipeline is connected with above-mentioned blood circuit, and priming fluid can be supplied to the blood
The inside in loop；
Priming fluid discharge unit, the priming fluid discharge unit can make the priming fluid supplied by above-mentioned priming fluid supply pipeline and above-mentioned
Air in blood circuit is discharged to outside from blood circuit overflow；
1st valve system, the 1st valve system can be closed arbitrarily or open above-mentioned priming fluid supply pipeline；
2nd valve system, the 2nd valve system can be closed arbitrarily or open above-mentioned priming fluid discharge unit；
Controlling organization, the controlling organization can control above-mentioned blood pump, the 1st valve system and the 2nd valve system；
Between above-mentioned blood pump and blood purification mechanism in above-mentioned arterial side blood circuit, arterial side air pocket room is connected；
In the apparatus for purifying blood, the state being in upward in the blood introducing port of above-mentioned blood purification mechanism carries out pre-
Fill, it is characterised in that
Above-mentioned controlling organization carries out following steps of exhausting, in the steps of exhausting, in preliminary filling, carries out above-mentioned blood pump reverse
Driving, and above-mentioned priming fluid discharge unit and above-mentioned priming fluid supply pipeline are opened, and the actuating speed of above-mentioned blood pump is pressed
Mode according to the flow less than the priming fluid supplied from priming fluid supply pipeline is set, while being supplied from the priming fluid supply pipeline
Priming fluid, while discharging priming fluid and air from above-mentioned priming fluid discharge unit.
2. apparatus for purifying blood according to claim 1, it is characterised in that connect quiet on above-mentioned venous side blood circuit
Arteries and veins side air pocket room, and above-mentioned priming fluid discharge unit is by the extended overflow line structure in the top from the venous side air pocket room
Into.
3. a kind of method for pre-charging of apparatus for purifying blood, the apparatus for purifying blood includes：
Blood circuit, the blood circuit is made up of arterial side blood circuit and venous side blood circuit, and can be by the blood of patient
Liquid is from the front end extracorporal circulatory system of the arterial side blood circuit to the front end of venous side blood circuit；
Blood purification mechanism, the blood purification mechanism is situated between located at the arterial side blood circuit and venous side blood time of the blood circuit
Between road, the blood for flowing through the blood circuit is purified, and formed via the membrane for purifying blood purified to blood
Make the blood pathway that the blood of patient flows through and the dialysate circuit for flowing through dialyzate, the blood purification mechanism has can be by
Blood introducing port that blood is imported in the blood pathway, can by blood derived from the blood pathway blood export mouth, can will be thoroughly
Dialyzate introducing port and dialyzate can be dialysed derived from the dialysate circuit that analysis liquid is imported in above-mentioned dialysate circuit
Liquid export mouth；
Blood pump, the blood pump is arranged in above-mentioned arterial side blood circuit, and can be carried out：In blood purification treatment along blood
Forward drive and edge and the direction in opposite direction of blood circulation drive in blood purification treatment that the direction of liquid circulation drives
Reverse drive；
Priming fluid supply pipeline, the priming fluid supply pipeline is connected with above-mentioned blood circuit, and priming fluid can be supplied to the blood
The inside in loop；
Priming fluid discharge unit, the priming fluid discharge unit can be by the priming fluid supplied by above-mentioned priming fluid supply pipeline and above-mentioned
Air in blood circuit is discharged to outside from blood circuit overflow；
1st valve system, the 1st valve system can be closed arbitrarily or open above-mentioned priming fluid supply pipeline；
2nd valve system, the 2nd valve system can be closed arbitrarily or open above-mentioned priming fluid discharge unit,
Between above-mentioned blood pump and blood purification mechanism in above-mentioned arterial side blood circuit, arterial side air pocket room is connected；
In the method for pre-charging of the apparatus for purifying blood, it is in upward in the blood introducing port of above-mentioned blood purification mechanism
State carries out preliminary filling, it is characterised in that
Following steps of exhausting are carried out, in the steps of exhausting, in preliminary filling, above-mentioned blood pump is carried out reverse drive, and will
Above-mentioned priming fluid discharge unit and above-mentioned priming fluid supply pipeline are opened, and above-mentioned blood pump actuating speed according to less than from preliminary filling
The mode of the flow of the priming fluid of liquid supply pipeline supply is set, while supplying priming fluid from the priming fluid supply pipeline, on one side
Priming fluid and air are discharged from above-mentioned priming fluid discharge unit.
4. the method for pre-charging of apparatus for purifying blood according to claim 3, it is characterised in that returned in above-mentioned venous side blood
Venous side air pocket room is connected on road, and above-mentioned priming fluid discharge unit is by overflowing for being extended from the top of the venous side air pocket room
Flow tube line is constituted.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013-232944 | 2013-11-11 | ||
| JP2013232944A JP5808062B2 (en) | 2013-11-11 | 2013-11-11 | Blood purification apparatus and priming method thereof |
| PCT/JP2014/079688 WO2015068833A1 (en) | 2013-11-11 | 2014-11-10 | Blood purification device and method for priming same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105705175A CN105705175A (en) | 2016-06-22 |
| CN105705175B true CN105705175B (en) | 2017-07-11 |
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| CN201480061260.8A Active CN105705175B (en) | 2013-11-11 | 2014-11-10 | Apparatus for purifying blood and its method for pre-charging |
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| Country | Link |
|---|---|
| US (1) | US10195336B2 (en) |
| EP (1) | EP3069742B1 (en) |
| JP (1) | JP5808062B2 (en) |
| CN (1) | CN105705175B (en) |
| WO (1) | WO2015068833A1 (en) |
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| EP3505200B1 (en) | 2017-12-29 | 2020-09-09 | Gambro Lundia AB | Apparatus for extracorporeal blood treatment |
| JP6571234B1 (en) | 2018-03-26 | 2019-09-04 | 日機装株式会社 | Blood purification equipment |
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Also Published As
| Publication number | Publication date |
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| WO2015068833A1 (en) | 2015-05-14 |
| EP3069742A1 (en) | 2016-09-21 |
| EP3069742A4 (en) | 2017-06-21 |
| US10195336B2 (en) | 2019-02-05 |
| JP5808062B2 (en) | 2015-11-10 |
| CN105705175A (en) | 2016-06-22 |
| JP2015092977A (en) | 2015-05-18 |
| US20160250405A1 (en) | 2016-09-01 |
| EP3069742B1 (en) | 2019-05-01 |
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