CN105705147B - 新颖的噁唑烷酮抗菌化合物 - Google Patents

新颖的噁唑烷酮抗菌化合物 Download PDF

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Publication number
CN105705147B
CN105705147B CN201480060357.7A CN201480060357A CN105705147B CN 105705147 B CN105705147 B CN 105705147B CN 201480060357 A CN201480060357 A CN 201480060357A CN 105705147 B CN105705147 B CN 105705147B
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China
Prior art keywords
formula
compound
base
methyl
fluoro
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN201480060357.7A
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English (en)
Chinese (zh)
Other versions
CN105705147A (zh
Inventor
拉古·米特拉·阿拉
阿贾伊·库马尔·迪贝
斯里尼瓦斯·雷迪·马勒帕里
拉玛克里什那·雷迪·庞吉拉蒂
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Lee Pharma Ltd
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Lee Pharma Ltd
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Publication of CN105705147A publication Critical patent/CN105705147A/zh
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Expired - Fee Related legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201480060357.7A 2013-11-08 2014-07-28 新颖的噁唑烷酮抗菌化合物 Expired - Fee Related CN105705147B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IN5063CH2013 2013-11-08
IN5063/CHE/2013 2013-11-08
IN2254/CHE/2014 2014-05-05
IN2254CH2014 2014-05-05
PCT/IN2014/000497 WO2015068173A1 (en) 2013-11-08 2014-07-28 Novel oxazolidinone antibacterial compound

Publications (2)

Publication Number Publication Date
CN105705147A CN105705147A (zh) 2016-06-22
CN105705147B true CN105705147B (zh) 2019-06-28

Family

ID=53040992

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480060357.7A Expired - Fee Related CN105705147B (zh) 2013-11-08 2014-07-28 新颖的噁唑烷酮抗菌化合物

Country Status (6)

Country Link
US (1) US9573910B2 (enExample)
EP (1) EP3065740B1 (enExample)
JP (1) JP6286536B2 (enExample)
CN (1) CN105705147B (enExample)
ES (1) ES2699001T3 (enExample)
WO (1) WO2015068173A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115707685A (zh) * 2021-08-20 2023-02-21 中国石油化工股份有限公司 一种制备胺-环氧卤丙烷聚合单体的方法及产物和系统
CN114230547A (zh) * 2021-12-29 2022-03-25 江苏广域化学有限公司 取代苯甲醛缩醇的合成方法
CN116919954A (zh) * 2023-05-22 2023-10-24 成都大学 噁唑烷酮类化合物在制备抑制细菌群体感应的药物中的应用
CN118515624B (zh) * 2024-04-29 2025-01-24 聊城金歌合成材料有限公司 一种含三氟甲基多取代恶唑烷-4-酮的合成方法及应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1130379A (zh) * 1993-09-09 1996-09-04 厄普约翰公司 取代的噁嗪和噻嗪噁唑烷酮抗微生物剂
CN1355165A (zh) * 2001-12-19 2002-06-26 中国医学科学院医药生物技术研究所 3,5－取代噁唑烷酮衍生物及其制备方法和应用
CN102112471A (zh) * 2008-07-01 2011-06-29 菲尔若国际公司 作为抗菌剂的3-氰基吡咯烷基-苯基-噁唑烷酮

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1260948A (en) * 1984-12-05 1989-09-26 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents
US5688792A (en) * 1994-08-16 1997-11-18 Pharmacia & Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
EP1049682A1 (en) * 1998-01-23 2000-11-08 Versicor, Inc. Oxazolidinone combinatorial libraries, compositions and methods of preparation
JPH11322729A (ja) * 1998-03-09 1999-11-24 Hokuriku Seiyaku Co Ltd ジチオカルバミド酸誘導体
US6689779B2 (en) 2000-06-05 2004-02-10 Dong A Pharm. Co., Ltd. Oxazolidinone derivatives and a process for the preparation thereof
TW200302095A (en) * 2002-01-25 2003-08-01 Upjohn Co Oxazolidinone cotherapy
EP2163547A1 (en) * 2008-09-16 2010-03-17 Unión Químico Farmacéutica, S.A. (UQUIFA) Process for the preparation of an oxazolidinone antibacterial agent and intermediates thereof
WO2015068171A1 (en) 2013-11-08 2015-05-14 Lee Pharma Limited Novel oxazolidinone compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1130379A (zh) * 1993-09-09 1996-09-04 厄普约翰公司 取代的噁嗪和噻嗪噁唑烷酮抗微生物剂
CN1355165A (zh) * 2001-12-19 2002-06-26 中国医学科学院医药生物技术研究所 3,5－取代噁唑烷酮衍生物及其制备方法和应用
CN102112471A (zh) * 2008-07-01 2011-06-29 菲尔若国际公司 作为抗菌剂的3-氰基吡咯烷基-苯基-噁唑烷酮

Also Published As

Publication number Publication date
US9573910B2 (en) 2017-02-21
WO2015068173A1 (en) 2015-05-14
EP3065740A4 (en) 2017-04-19
JP2016535039A (ja) 2016-11-10
CN105705147A (zh) 2016-06-22
JP6286536B2 (ja) 2018-02-28
EP3065740A1 (en) 2016-09-14
ES2699001T3 (es) 2019-02-06
US20160272597A1 (en) 2016-09-22
EP3065740B1 (en) 2018-08-22

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Granted publication date: 20190628