CN105705018B - (s,s)‑开环异落叶松树脂酚二葡糖苷和(r,r)‑开环异落叶松树脂酚二葡糖苷的制备 - Google Patents

(s,s)‑开环异落叶松树脂酚二葡糖苷和(r,r)‑开环异落叶松树脂酚二葡糖苷的制备 Download PDF

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CN105705018B
CN105705018B CN201480041131.2A CN201480041131A CN105705018B CN 105705018 B CN105705018 B CN 105705018B CN 201480041131 A CN201480041131 A CN 201480041131A CN 105705018 B CN105705018 B CN 105705018B
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formula
sdg
meoh
reaction
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CN105705018A (zh
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M·克里斯托菲多-索罗米多
K·C·尼科拉乌
R·A·瓦利乌林
N·西蒙斯
P·M·埃雷奇
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Scripps Research Institute
University of Pennsylvania Penn
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University of Pennsylvania Penn
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/303—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by hydrogenation of unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
CN201480041131.2A 2013-06-10 2014-06-10 (s,s)‑开环异落叶松树脂酚二葡糖苷和(r,r)‑开环异落叶松树脂酚二葡糖苷的制备 Active CN105705018B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201711326022.7A CN107955046A (zh) 2013-06-10 2014-06-10 开环异落叶松树脂酚二葡糖苷的制备

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361833258P 2013-06-10 2013-06-10
US61/833,258 2013-06-10
PCT/US2014/041636 WO2014200964A1 (en) 2013-06-10 2014-06-10 Preparation of (s,s)-secoisolariciresinol diglucoside and (r,r)-secoisolariciresinol diglucoside

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CN105705018B true CN105705018B (zh) 2018-01-12

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CN201480041131.2A Active CN105705018B (zh) 2013-06-10 2014-06-10 (s,s)‑开环异落叶松树脂酚二葡糖苷和(r,r)‑开环异落叶松树脂酚二葡糖苷的制备

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US (2) US10030040B2 (enExample)
EP (2) EP3488697A1 (enExample)
JP (3) JP6321788B2 (enExample)
KR (1) KR102270124B1 (enExample)
CN (2) CN107955046A (enExample)
AU (1) AU2014278362B2 (enExample)
CA (1) CA2920346A1 (enExample)
CY (1) CY1120759T1 (enExample)
DK (1) DK3007557T3 (enExample)
ES (1) ES2691845T3 (enExample)
HR (1) HRP20181663T1 (enExample)
HU (1) HUE040022T2 (enExample)
IL (2) IL243029B (enExample)
LT (1) LT3007557T (enExample)
PL (1) PL3007557T3 (enExample)
PT (1) PT3007557T (enExample)
RS (1) RS57846B1 (enExample)
SI (1) SI3007557T1 (enExample)
SM (1) SMT201800575T1 (enExample)
TR (1) TR201815423T4 (enExample)
WO (1) WO2014200964A1 (enExample)

Families Citing this family (9)

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Publication number Priority date Publication date Assignee Title
US10030040B2 (en) * 2013-06-10 2018-07-24 The Trustees Of The University Of Pennsylvania Preparation of (S,S)-secoisolariciresinol diglucoside and (R,R)-secoisolariciresinol diglucoside
CA2950744A1 (en) * 2014-05-30 2015-12-03 The Trustees Of The University Of Pennsylvania Use of secoisolariciresinol diglucosides (sdgs) and related compounds for protection against radiation and chemical damage
US11197876B2 (en) 2014-05-30 2021-12-14 The Trusiees Of The University Of Pennsylvania Effects of LGM2605 on a primate model of asthma
US20170258821A1 (en) 2014-05-30 2017-09-14 The Trustees Of The University Of Pennsylvania USE OF SECOISOLARICIRESINOL DIGLUCOSIDES (SDGs) AND RELATED COMPOUNDS FOR PROTECTION AGAINST RADIATION AND CHEMICAL DAMAGE
JP2018528208A (ja) * 2015-09-01 2018-09-27 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 放射線損傷からの保護のためのセコイソラリシレシノールジグルコシド（ｓｄｇ）および関連化合物の使用
ES2969209T3 (es) 2016-06-07 2024-05-17 Univ Pennsylvania Composiciones y métodos para proteger órganos de lesiones por isquemia/reperfusión asociadas con el trasplante
KR20200016372A (ko) 2017-06-12 2020-02-14 리그나메드, 엘엘씨 (s,s)-세코이소라리시레시놀 디글루코시드 및 (r,r)-세코이소라리시레시놀 디글루코시드의 제조 방법
CN110283218A (zh) * 2019-06-24 2019-09-27 暨南大学 提高木酚素油溶性的改性方法
CN111233944B (zh) * 2020-03-25 2023-02-28 宝鸡市辰光生物科技有限公司 一种同时制备分离四种木脂素类成分的高效液相方法

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CN101117641A (zh) * 2007-07-27 2008-02-06 大连医诺生物有限公司 开环异落叶松树脂酚二葡萄糖苷的制备方法
CN102050848A (zh) * 2009-11-01 2011-05-11 桂林莱茵生物科技股份有限公司 一种亚麻木酚素的制备方法
EP2514426A1 (en) * 2009-12-15 2012-10-24 Consejo Superior De Investigaciones Científicas (CSIC) Compounds having anti-inflammatory activity

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US6911330B1 (en) * 1998-04-24 2005-06-28 Washington State University Research Foundation Recombinant secoisolariciciresinol dehydrogensase, and methods of use
FI110868B (fi) * 2001-01-22 2003-04-15 Maa Ja Elintarviketalouden Tut Menetelmä sekoisolarisiresinolidiglykosidin (SDG) eristämiseksi ja puhdistamiseksi pellavansiemenistä
US20030060420A1 (en) 2001-09-14 2003-03-27 Rick Heintzman Process for extraction and stabilization of phytoestrogens from flaxseed and product therefrom
EP1490380B1 (en) 2002-04-02 2010-07-14 Lignan Research, LLC Aprocess for recovering secoisolariciresinol diglycoside from de-fatted flaxseed
JP2006347978A (ja) * 2005-06-17 2006-12-28 Nippon Flour Mills Co Ltd 抗肥満剤及びこれを含む食品並びにペットフード
JP2007308469A (ja) * 2005-11-11 2007-11-29 Nippon Flour Mills Co Ltd リグナンを有効成分とする男性用抗肥満剤
CN100395253C (zh) * 2006-05-12 2008-06-18 中国科学院山西煤炭化学研究所 一种由亚麻籽制备开环异落叶松树脂酚二葡萄糖苷的方法
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CN102050848A (zh) * 2009-11-01 2011-05-11 桂林莱茵生物科技股份有限公司 一种亚麻木酚素的制备方法
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AU2014278362B2 (en) 2017-07-13
AU2014278362A1 (en) 2016-02-04
KR102270124B1 (ko) 2021-06-25
CN105705018A (zh) 2016-06-22
PL3007557T3 (pl) 2019-04-30
EP3007557B1 (en) 2018-07-18
IL269622A (en) 2019-11-28
US10870670B2 (en) 2020-12-22
CA2920346A1 (en) 2014-12-18
TR201815423T4 (tr) 2018-11-21
SI3007557T1 (sl) 2018-12-31
LT3007557T (lt) 2018-11-12
JP2016521748A (ja) 2016-07-25
CY1120759T1 (el) 2019-12-11
JP6785335B2 (ja) 2020-11-18
HUE040022T2 (hu) 2019-02-28
IL243029B (en) 2019-09-26
ES2691845T3 (es) 2018-11-28
WO2014200964A1 (en) 2014-12-18
KR20160023770A (ko) 2016-03-03
EP3488697A1 (en) 2019-05-29
JP2019147803A (ja) 2019-09-05
HK1223792A1 (zh) 2017-08-11
CN107955046A (zh) 2018-04-24
JP6321788B2 (ja) 2018-05-09
JP6513853B2 (ja) 2019-05-15
JP2018111721A (ja) 2018-07-19
US20160137682A1 (en) 2016-05-19
SMT201800575T1 (it) 2019-01-11
US10030040B2 (en) 2018-07-24
HRP20181663T1 (hr) 2018-12-14
EP3007557A1 (en) 2016-04-20
US20190062363A1 (en) 2019-02-28
PT3007557T (pt) 2018-11-09
EP3007557A4 (en) 2017-01-18
RS57846B1 (sr) 2018-12-31
DK3007557T3 (en) 2018-11-05

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