CN105688214A - 用于影响神经功能的药剂、方法和设备 - Google Patents

用于影响神经功能的药剂、方法和设备 Download PDF

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Publication number
CN105688214A
CN105688214A CN201610042158.4A CN201610042158A CN105688214A CN 105688214 A CN105688214 A CN 105688214A CN 201610042158 A CN201610042158 A CN 201610042158A CN 105688214 A CN105688214 A CN 105688214A
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nerve
needle
delivery
agents
shows
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艾米丽·A·斯坦
克里斯蒂娜·D·斯汪森
迈克尔·A·埃文斯
空达帕瓦勒·T·文卡特斯瓦拉-拉欧
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    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61M25/0067Catheters; Hollow probes characterised by the distal end, e.g. tips
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • Psychiatry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
CN201610042158.4A 2011-10-26 2012-10-25 用于影响神经功能的药剂、方法和设备 Pending CN105688214A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161551921P 2011-10-26 2011-10-26
US61/551,921 2011-10-26
CN201280064573.XA CN104203233A (zh) 2011-10-26 2012-10-25 用于影响神经功能的药剂、方法和设备

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CN105688214A true CN105688214A (zh) 2016-06-22

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CN201610042158.4A Pending CN105688214A (zh) 2011-10-26 2012-10-25 用于影响神经功能的药剂、方法和设备
CN201280064573.XA Pending CN104203233A (zh) 2011-10-26 2012-10-25 用于影响神经功能的药剂、方法和设备

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US (1) US20150202220A1 (https=)
EP (1) EP2770992A4 (https=)
JP (1) JP2014532654A (https=)
CN (2) CN105688214A (https=)
CA (1) CA2853466A1 (https=)
WO (1) WO2013063331A1 (https=)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6302875B1 (en) 1996-10-11 2001-10-16 Transvascular, Inc. Catheters and related devices for forming passageways between blood vessels or other anatomical structures
US7653438B2 (en) 2002-04-08 2010-01-26 Ardian, Inc. Methods and apparatus for renal neuromodulation
US20070135875A1 (en) 2002-04-08 2007-06-14 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US7617005B2 (en) 2002-04-08 2009-11-10 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US8150519B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods and apparatus for bilateral renal neuromodulation
US20070129761A1 (en) 2002-04-08 2007-06-07 Ardian, Inc. Methods for treating heart arrhythmia
US20080213331A1 (en) 2002-04-08 2008-09-04 Ardian, Inc. Methods and devices for renal nerve blocking
US6978174B2 (en) 2002-04-08 2005-12-20 Ardian, Inc. Methods and devices for renal nerve blocking
US9636174B2 (en) 2002-04-08 2017-05-02 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
JP5219518B2 (ja) 2004-12-09 2013-06-26 ザ ファウンドリー, エルエルシー 大動脈弁修復
US20120259269A1 (en) 2011-04-08 2012-10-11 Tyco Healthcare Group Lp Iontophoresis drug delivery system and method for denervation of the renal sympathetic nerve and iontophoretic drug delivery
US9237925B2 (en) 2011-04-22 2016-01-19 Ablative Solutions, Inc. Expandable catheter system for peri-ostial injection and muscle and nerve fiber ablation
US8663190B2 (en) 2011-04-22 2014-03-04 Ablative Solutions, Inc. Expandable catheter system for peri-ostial injection and muscle and nerve fiber ablation
US20130053792A1 (en) 2011-08-24 2013-02-28 Ablative Solutions, Inc. Expandable catheter system for vessel wall injection and muscle and nerve fiber ablation
US9056185B2 (en) 2011-08-24 2015-06-16 Ablative Solutions, Inc. Expandable catheter system for fluid injection into and deep to the wall of a blood vessel
US10881458B2 (en) 2012-10-29 2021-01-05 Ablative Solutions, Inc. Peri-vascular tissue ablation catheters
US10226278B2 (en) 2012-10-29 2019-03-12 Ablative Solutions, Inc. Method for painless renal denervation using a peri-vascular tissue ablation catheter with support structures
US9301795B2 (en) 2012-10-29 2016-04-05 Ablative Solutions, Inc. Transvascular catheter for extravascular delivery
US9526827B2 (en) 2012-10-29 2016-12-27 Ablative Solutions, Inc. Peri-vascular tissue ablation catheter with support structures
US10945787B2 (en) 2012-10-29 2021-03-16 Ablative Solutions, Inc. Peri-vascular tissue ablation catheters
US10736656B2 (en) 2012-10-29 2020-08-11 Ablative Solutions Method for painless renal denervation using a peri-vascular tissue ablation catheter with support structures
CA3177929A1 (en) 2012-12-21 2014-06-26 Astellas Institute For Regenerative Medicine Methods for production of platelets from pluripotent stem cells and compositions thereof
US9949652B2 (en) 2013-10-25 2018-04-24 Ablative Solutions, Inc. Apparatus for effective ablation and nerve sensing associated with denervation
US9931046B2 (en) 2013-10-25 2018-04-03 Ablative Solutions, Inc. Intravascular catheter with peri-vascular nerve activity sensors
US10517666B2 (en) 2013-10-25 2019-12-31 Ablative Solutions, Inc. Apparatus for effective ablation and nerve sensing associated with denervation
US10286190B2 (en) 2013-12-11 2019-05-14 Cook Medical Technologies Llc Balloon catheter with dynamic vessel engaging member
US9855317B2 (en) 2015-04-27 2018-01-02 Reflex Medical, Inc. Systems and methods for sympathetic cardiopulmonary neuromodulation
US10675085B2 (en) 2015-11-23 2020-06-09 Boston Scientific Scimed, Inc. Devices and methods for enhanced denervation procedures
US11116561B2 (en) 2018-01-24 2021-09-14 Medtronic Ardian Luxembourg S.A.R.L. Devices, agents, and associated methods for selective modulation of renal nerves
US10849685B2 (en) 2018-07-18 2020-12-01 Ablative Solutions, Inc. Peri-vascular tissue access catheter with locking handle
US20200069366A1 (en) * 2018-08-29 2020-03-05 Boston Scientific Scimed, Inc. Combination denervation therapy for glucose control in metabolic disorders
US12114919B2 (en) 2018-10-24 2024-10-15 Boston Scientific Scimed, Inc. Movable electrodes for controlled irreversible electroporation ablative volumes
CN112085991A (zh) * 2020-10-15 2020-12-15 福建中医药大学附属人民医院(福建省人民医院) 一种疼痛医疗临床实训用神经节阻滞治疗训练模型

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1109872A (zh) * 1993-12-30 1995-10-11 赫彻斯特股份公司 取代苯磺酰脲和一硫脲,其制备方法及其药物制剂用途
CN1400871A (zh) * 2000-02-14 2003-03-05 菲仕兰品牌公司 谷氨酸和/或谷氨酸前体用于制备治疗或预防肠壁渗透性过高或不期望的渗透性的营养或药物制剂的用途
CN101573338A (zh) * 2006-12-27 2009-11-04 塞诺菲-安万特股份有限公司 环烷基胺取代的异喹诺酮和异喹啉酮衍生物
WO2010149769A1 (en) * 2009-06-26 2010-12-29 Galapagos Nv 5-phenyl-[1,2,4 ]triazolo[1,5-a]pyridin-2-yl carboxamides as jak inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6735471B2 (en) * 1996-04-30 2004-05-11 Medtronic, Inc. Method and system for endotracheal/esophageal stimulation prior to and during a medical procedure
US20060167498A1 (en) * 2001-07-23 2006-07-27 Dilorenzo Daniel J Method, apparatus, and surgical technique for autonomic neuromodulation for the treatment of disease
US6978174B2 (en) * 2002-04-08 2005-12-20 Ardian, Inc. Methods and devices for renal nerve blocking
CA2575458C (en) * 2004-07-28 2015-06-02 Ardian, Inc. Methods and devices for renal nerve blocking
CN105056408B (zh) * 2006-06-28 2018-09-25 美敦力Af卢森堡公司 用于热诱导的肾神经调制的系统
WO2010124120A1 (en) * 2009-04-22 2010-10-28 Mercator Medsystems, Inc. Use of guanethidine for treating hypertension by local vascular delivery
CN102892454B (zh) * 2010-01-26 2016-01-20 迈克尔·A·埃文斯 用于去神经支配的方法、装置以及药剂

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1109872A (zh) * 1993-12-30 1995-10-11 赫彻斯特股份公司 取代苯磺酰脲和一硫脲,其制备方法及其药物制剂用途
CN1400871A (zh) * 2000-02-14 2003-03-05 菲仕兰品牌公司 谷氨酸和/或谷氨酸前体用于制备治疗或预防肠壁渗透性过高或不期望的渗透性的营养或药物制剂的用途
CN101573338A (zh) * 2006-12-27 2009-11-04 塞诺菲-安万特股份有限公司 环烷基胺取代的异喹诺酮和异喹啉酮衍生物
WO2010149769A1 (en) * 2009-06-26 2010-12-29 Galapagos Nv 5-phenyl-[1,2,4 ]triazolo[1,5-a]pyridin-2-yl carboxamides as jak inhibitors

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
L. SAFTA,等: "The central arrhythmogenic effects of sodium aspartate in anesthetized rats", 《CURRENT THERAPEUTIC RESEARCH》 *
SUSHIL K.SHARMA,等: "Domoic acid as a tool in molecular pharmacology", 《PHARMACOLOGY AND THERAPEUTICS IN THE NEW MILLENNIUM》 *
王慎传,等: "肝昏迷患者静点谷氨酸钾所致的心律失常", 《临床肝胆病杂志》 *

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