CN105687901A - Traditional Chinese medicine for treating hyperuricemia - Google Patents

Traditional Chinese medicine for treating hyperuricemia Download PDF

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CN105687901A
CN105687901A CN201610131201.4A CN201610131201A CN105687901A CN 105687901 A CN105687901 A CN 105687901A CN 201610131201 A CN201610131201 A CN 201610131201A CN 105687901 A CN105687901 A CN 105687901A
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chinese medicine
hyperuricemia
traditional chinese
filtrate
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张超
许爱梅
张方华
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Qingdao Central Hospital
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Qingdao Central Hospital
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8994—Coix (Job's tears)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/58—Reptiles
    • A61K35/583—Snakes; Lizards, e.g. chameleons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708—Rheum (rhubarb)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/744—Gardenia
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
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    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

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Abstract

The invention provides a traditional Chinese medicine for treating hyperuricemia. The traditional Chinese medicine is prepared from components in parts by weight as follows: 10-20 parts of Indian iphigenia bulb, 5-15 parts of sophora japonica, 10-20 parts of coix seeds, 5-15 parts of wine-processed rhubarb, 10-20 parts of ephedra herbs, 5-15 parts of hairyvein agrimonia herbs and buds, 5-15 parts of garter snakes, 10-20 parts of kadsura pepper stems, 5-15 parts of pubescent angelica roots, 10-15 parts of cape jasmines and 10-15 parts of poria cocos. The medicine is prepared from pure traditional Chinese medicine preparations, does not have side effects on bodies and has a good treatment effect on hyperuricemia, and the treatment cycle is short.

Description

A kind of Chinese medicine treating hyperuricemia
Technical field
The invention belongs to the field of Chinese medicines, relate to a kind of Chinese medicine treating hyperuricemia。
Background technology
Hyperuricemia (HUA) refers under normal purine diet state, and non-twice fasting blood uric acid level male is higher than 420 μm of ol/L on the same day, and women is higher than 360 μm of ol/L, is namely called hyperuricemia。Hyperuricemia is the prelude of gout, namely the early stage performance of gout。
There is the Western medicine of some treatment hyperuricemias at present, but this kind of generally unsuitable long-term taking, the damage of kidney is bigger。
Summary of the invention
In order to solve problem of the prior art, the invention provides a kind of Chinese medicine treating hyperuricemia, this Chinese medicine is selected from pure Chinese medicinal preparation, and health is had no side effect, it is therefore intended that conditioning health mechanism of qi, makes hyperuricemia be restored。
In order to achieve the above object, the present invention adopts the following technical scheme that
A kind of Chinese medicine treating hyperuricemia, composition including following weight portion: Pseudobulbus Cremastrae Seu Pleiones 10-20 part, Flos Sophorae 5-15 part, Semen Coicis 10-20 part, Radix et Rhizoma Rhei (stir-fried with wine) 5-15 part, Herba Ephedrae 10-20 part, Herba Agrimoniae 5-15 part, Zaocys 5-15 part, Caulis Piperis Kadsurae 10-20 part, Radix Angelicae Pubescentis 5-15 part, Fructus Gardeniae 10-15 part, Poria 10-15 part。
Preferably, a kind of Chinese medicine treating hyperuricemia, including the composition of following weight portion: Pseudobulbus Cremastrae Seu Pleiones 15 parts, 8 parts of Flos Sophorae, Semen Coicis 18 parts, Radix et Rhizoma Rhei (stir-fried with wine) 13 parts, 16 parts of Herba Ephedrae, Herba Agrimoniae 11 parts, Zaocys 9 parts, Caulis Piperis Kadsurae 15 parts, Radix Angelicae Pubescentis 8 parts, Fructus Gardeniae 12 parts, 12 parts of Poria。
The preparation method of the Chinese medicine of described treatment hyperuricemia, comprises the following steps:
(1) weighing described Chinese medicine according to weight, add immersion 6～8h in the water of 2～3 times, big fire is boiled, and simmer in water 1～2h afterwards, and decoction liquor is filtrated to get the first filtrate；
(2) gained filtering residue in step (1) being added the water of 2～3 times again, big fire is boiled, and slow fire boils 1～2h afterwards, and decoction liquor is filtrated to get the second filtrate；
(3) twice gained filtrate is merged, it is thus achieved that decoct, decoct part vic, each 200～300mL。
Pharmacology analysis:
Pseudobulbus Cremastrae Seu Pleiones: sweet, micro-pungent is cool。Return liver, spleen channel。Heat-clearing and toxic substances removing, dissipating phlegm and resolving masses。For carbuncle furunculosis, scrofula sucutaneous nodule, snake bite and insect sting, lame abdominal mass mass in the abdomen。
Flos Sophorae: bitter in the mouth, cold nature, returns liver, large intestine channel；Entering blood to hold back and drop, body slightly dissipates。There is cooling blood for hemostasis, effect of purging liver-fire。
Semen Coicis: sweet, light is cool。Return spleen, stomach, lung meridian。Promoting diuresis to eliminate damp pathogen, invigorating the spleen to arrest diarrhea, eliminating impediment, evacuation of pus, detoxicating and resolving stagnation of pathogens。For edema, beriberi, dysuria, diarrhea due to hypofunction of the spleen, arthralgia chiefly caused by damp pathogen contracture, lung abscess, acute appendicitis, wart, cancerous protuberance。
Radix et Rhizoma Rhei (stir-fried with wine): bitter, cold。Return spleen, stomach, large intestine, liver, pericardium channel。Clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system。For conjunctival congestion pharyngeal swelling, gingivitis。
Herba Ephedrae: hardship pungent, micro-, temperature。Return lung, bladder warp。Diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema。For anemofrigid cold, uncomfortable in chest breath with cough, edema due to wind pathogen edema。Herba ephedrae nourishing the lung to arrest cough。It is used for exterior syndrome to solve, asthma and cough。
Herba Agrimoniae: bitter, puckery is flat。GUIXIN, Liver Channel。Astringing to arrest bleeding, preventing the attack (or recurrence) of malaria, dysentery relieving, removing toxic substances, qi-restoratives。For spitting blood, spit blood, metrostaxis, malaria, dysentery, carbuncle sore tumefacting virus, pudendal pruritus leukorrhagia, de-power impairment caused by overstrain。
Zaocys: sweet is flat。Return Liver Channel。Dispel the wind, dredging collateral, relieving convulsion。For rheumatoid arthritis stubborn, numb, contracture, middle air port eye fish sticking its mouth out of the water tiltedly, hemiplegia, tic spasm, tetanus, leprosy, scabies。
Caulis Piperis Kadsurae: acrid in the mouth, hardship, slightly warm in nature。Return Liver Channel。Wind-damp dispelling, the meridian dredging, stopping numbness pain。In anemofrigid-damp arthralgia, arthrodynia of extremities, muscle arteries and veins contracture, joint stuffiness。
Radix Angelicae Pubescentis: pungent, bitter, tepor。Return kidney, bladder warp。Expelling wind and removing dampness, numbness relieving and pain relieving。For anemofrigid-damp arthralgia, lumbocrural pain, few the moon volt wind headache, wind and cold holds wet headache under the arm。
Fructus Gardeniae: bitter, cold。GUIXIN, lung, tri-jiao channel。Pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body；Externally used detumescence pain relieving。Vexed for calentura, jaundice due to damp-heat, the puckery pain of stranguria, heat in blood tells nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles, external treatment bruise pain。
Poria: sweet, light is flat。GUIXIN, lung, spleen, kidney channel。Promoting diuresis to eliminate damp pathogen, spleen invigorating, mind calming。For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia。
Traditional Chinese medical science angle, hyperuricemia is due to weakness of the spleen and stomach, exopathogen invasion causes, Caulis Piperis Kadsurae the meridian dredging in the present invention, stopping numbness pain, Radix Angelicae Pubescentis expelling wind and removing dampness, numbness relieving and pain relieving, the two is monarch drug altogether, Herba Agrimoniae qi-restoratives, Zaocys dispelling wind and removing obstruction in the collateral, the two is ministerial drug altogether, monarch drug and ministerial drug coordinate and are aided with Semen Coicis, Radix et Rhizoma Rhei (stir-fried with wine), the assistants such as Herba Ephedrae are so as to medicine, drug effect is gone directly focus, treatment hyperuricemia had significant effect, the Chinese medicine that the present invention selects is mainly promoting flow of QI and blood, the medicine of the meridian dredging, traditional Chinese medical science angle, gas general rule blood, QI-blood circulation is unobstructed, then in health, various materials are able to defeated cloth, each organ normal operation, and then physical function recovers, thus hyperuricemia is eliminated。
Beneficial effect:
(1) present invention is mainly in that the adjustment to physical function, makes it recover unobstructed gradually, and then makes indices recover normal, and treating both the principal and secondary aspects of a disease, therapeutic effect is notable；
(2) medical material is pure Chinese medicinal preparation, and character is gentle, and the stimulation of health is little, to internal organs fanout free region；
(3) treatment by Chinese herbs effect provided by the invention is notable, and cure rate, up to more than 95%, has blocked the morbidity source of gout, decreased the misery of patient。
Clinical data
1, case selection
Accept out-patient 200 example for medical treatment, be randomly divided into treatment group and matched group, treatment group 100 example, wherein male 53 example, women 47 example, the age is between 38～65 years old, 56 years old mean age, matched group 100 example, wherein male 51 example, women 49 example, age is between 35～65 years old, 55 years old mean age, treatment group and the course of disease of two groups of cases of matched group patient, symptom weight are basically identical, have comparability。
2, diagnostic criteria
Male and postmenopausal women, serum uric acid is about 420umol/L (7mg/dl) the saturated concentration of 37 degrees Celsius, is hyperuricemia higher than this value, and Pre-menopausal Women is diagnosable more than 360umol/L (6mg/l) for hyperuricemia。Urine has urate crystal。
3, Therapeutic Method
Treatment group adopts Chinese medicine preparation provided by the invention, and according to method provided by the invention, decoct every day 2 times, 5 days is a course for the treatment of。
Matched group takes probenecid sheet。
4, criterion of therapeutical effect
Cure: serum uric acid value recovers normal, checks in urine without urate crystal。
Taking a turn for the better: serum uric acid value reduces, urine uric acid salt-pepper noise reduces；
Invalid: serum uric acid value and urine uric acid salt-pepper noise are unchanged or have rising。
5, therapeutic outcome
In treatment group, curing 93 examples, cure rate 93%, take a turn for the better 6 examples, improvement rate 6%, invalid 1 example, total effective rate 99%, and in treatment group, general 2 courses for the treatment of can fully recover。
In matched group, curing 32 examples, cure rate 32%, take a turn for the better 18 examples, improvement rate 18%, invalid 50 examples, total effective rate 50%。
Treatment group effect is substantially better than matched group。
Detailed description of the invention
The present invention is further illustrated below in conjunction with embodiment。
Embodiment 1
A kind of Chinese medicine treating hyperuricemia, including the composition of following weight portion: Pseudobulbus Cremastrae Seu Pleiones 10 parts, 5 parts of Flos Sophorae, Semen Coicis 10 parts, Radix et Rhizoma Rhei (stir-fried with wine) 5 parts, 10 parts of Herba Ephedrae, Herba Agrimoniae 5 parts, Zaocys 5 parts, Caulis Piperis Kadsurae 10 parts, Radix Angelicae Pubescentis 5 parts, Fructus Gardeniae 10 parts, 10 parts of Poria。
The preparation method of the Chinese medicine of described treatment hyperuricemia, comprises the following steps:
(1) weighing described Chinese medicine according to weight, add immersion 6h in the water of 3 times, big fire is boiled, and simmer in water 1h afterwards, and decoction liquor is filtrated to get the first filtrate；
(2) gained filtering residue in step (1) being added the water of 3 times again, big fire is boiled, and slow fire boils 2h afterwards, and decoction liquor is filtrated to get the second filtrate；
(3) twice gained filtrate is merged, it is thus achieved that decoct, decoct part vic, each 250mL。
Embodiment 2
A kind of Chinese medicine treating hyperuricemia, including the composition of following weight portion: Pseudobulbus Cremastrae Seu Pleiones 15 parts, 8 parts of Flos Sophorae, Semen Coicis 18 parts, Radix et Rhizoma Rhei (stir-fried with wine) 13 parts, 16 parts of Herba Ephedrae, Herba Agrimoniae 11 parts, Zaocys 9 parts, Caulis Piperis Kadsurae 15 parts, Radix Angelicae Pubescentis 8 parts, Fructus Gardeniae 12 parts, 12 parts of Poria。
The preparation method of the Chinese medicine of described treatment hyperuricemia, comprises the following steps:
(1) weighing described Chinese medicine according to weight, add immersion 6h in the water of 2 times, big fire is boiled, and simmer in water 1h afterwards, and decoction liquor is filtrated to get the first filtrate；
(2) gained filtering residue in step (1) being added the water of 2 times again, big fire is boiled, and slow fire boils 1h afterwards, and decoction liquor is filtrated to get the second filtrate；
(3) twice gained filtrate is merged, it is thus achieved that decoct, decoct part vic, each 200mL。
A kind of Chinese medicine treating hyperuricemia, including the composition of following weight portion: Pseudobulbus Cremastrae Seu Pleiones 20 parts, 15 parts of Flos Sophorae, Semen Coicis 20 parts, Radix et Rhizoma Rhei (stir-fried with wine) 15 parts, 20 parts of Herba Ephedrae, Herba Agrimoniae 15 parts, Zaocys 15 parts, Caulis Piperis Kadsurae 20 parts, Radix Angelicae Pubescentis 15 parts, Fructus Gardeniae 15 parts, 15 parts of Poria。
The preparation method of the Chinese medicine of described treatment hyperuricemia, comprises the following steps:
(1) weighing described Chinese medicine according to weight, add immersion 7h in the water of 3 times, big fire is boiled, and simmer in water 2h afterwards, and decoction liquor is filtrated to get the first filtrate；
(2) gained filtering residue in step (1) being added the water of 3 times again, big fire is boiled, and slow fire boils 2h afterwards, and decoction liquor is filtrated to get the second filtrate；
(3) twice gained filtrate is merged, it is thus achieved that decoct, decoct part vic, each 300mL。
The specific embodiment of the present invention is described although above-mentioned in conjunction with the embodiments; but not limiting the scope of the invention; one of ordinary skill in the art should be understood that; on the basis of technical scheme, those skilled in the art need not pay various amendments or deformation that creative work can make still within protection scope of the present invention。

Claims (3)

1. treat a Chinese medicine for hyperuricemia, it is characterized in that, including the composition of following weight portion: Pseudobulbus Cremastrae Seu Pleiones 10-20 part, Flos Sophorae 5-15 part, Semen Coicis 10-20 part, Radix et Rhizoma Rhei (stir-fried with wine) 5-15 part, Herba Ephedrae 10-20 part, Herba Agrimoniae 5-15 part, Zaocys 5-15 part, Caulis Piperis Kadsurae 10-20 part, Radix Angelicae Pubescentis 5-15 part, Fructus Gardeniae 10-15 part, Poria 10-15 part。
2. a kind of Chinese medicine treating hyperuricemia as claimed in claim 1, is characterized in that, including the composition of following weight portion: Pseudobulbus Cremastrae Seu Pleiones 15 parts, 8 parts of Flos Sophorae, Semen Coicis 18 parts, Radix et Rhizoma Rhei (stir-fried with wine) 13 parts, 16 parts of Herba Ephedrae, Herba Agrimoniae 11 parts, Zaocys 9 parts, Caulis Piperis Kadsurae 15 parts, Radix Angelicae Pubescentis 8 parts, Fructus Gardeniae 12 parts, 12 parts of Poria。
3. the preparation method of the Chinese medicine treating hyperuricemia as claimed in claim 1 or 2, is characterized in that, comprise the following steps:
(1) weighing described Chinese medicine according to weight, add immersion 6～8h in the water of 2～3 times, big fire is boiled, and simmer in water 1～2h afterwards, and decoction liquor is filtrated to get the first filtrate；
(2) gained filtering residue in step (1) being added the water of 2～3 times again, big fire is boiled, and slow fire boils 1～2h afterwards, and decoction liquor is filtrated to get the second filtrate；
(3) twice gained filtrate is merged, it is thus achieved that decoct, decoct part vic, each 200～300mL。
CN201610131201.4A 2016-03-08 2016-03-08 Traditional Chinese medicine for treating hyperuricemia Pending CN105687901A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102309705A (en) * 2011-07-21 2012-01-11 杭州市中医院 Medicine for reducing serum uric acid, preparation method thereof and purpose thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102309705A (en) * 2011-07-21 2012-01-11 杭州市中医院 Medicine for reducing serum uric acid, preparation method thereof and purpose thereof

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Application publication date: 20160622