CN105687701A - Traditional Chinese medicine for treating neurasthenia insomnia - Google Patents
Traditional Chinese medicine for treating neurasthenia insomnia Download PDFInfo
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- CN105687701A CN105687701A CN201610252319.2A CN201610252319A CN105687701A CN 105687701 A CN105687701 A CN 105687701A CN 201610252319 A CN201610252319 A CN 201610252319A CN 105687701 A CN105687701 A CN 105687701A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention relates to a traditional Chinese medicine for treating neurasthenia insomnia. The traditional Chinese medicine can effectively achieve the purpose of medications for neurasthenia insomnia. According to the technical scheme, the traditional Chinese medicine is prepared from, by weight, 15-20 g of poria cum ligno hospite, 12-18 g of radix ophiopogonis, 20-30 g of fried jujube kernels, 6-9 g of arillus longan and 20-30 g of raw oyster shells. The traditional Chinese medicine can remarkably relieve insomnia symptoms, is definite in treatment effect, capable of taking effect fast, safe and reliable to take and free of toxic or side effects and is an innovation on medicine for treating neurasthenia insomnia.
Description
Technical field
The present invention relates to field of medicaments, particularly a kind of Chinese medicine treating neurasthenia's insomnia。
Background technology
Neurasthenia, also known as chronic fatigue syndrome (chronicfatiguesyndrome, CFS), is proposed by American Psychiatry disease scholar Beard and is named for 1869, and prevalence is 2.54%～10%。Neurasthenia and socio-psychological factors are closely related, and its pathogenesis is that long-term hyperpragic is nervous, causes the excitement of brain and suppresses functional disorder, neural activity thus be affected, thus causing one group of disordered brain function syndrome based on sleep disorder。Coordinating psychotherapy based on Drug therapy in treatment, Drug therapy has the shortcomings such as obvious side effect and drug dependence, and therapy of combining Chinese and Western medicine is one of study hotspot。At present, treatment neurasthenia does not cause effective Chinese medicine of insomnia, and therefore, the improvement on treatment neurasthenia's insomnia drug is the problem needing solution at present badly。
Summary of the invention
For above-mentioned situation, for solving the defect of prior art, the purpose of the present invention is just to provide a kind of Chinese medicine treating neurasthenia's insomnia, can effectively solve the medication problem of neurasthenia's insomnia。
Neurasthenia's insomnia belongs to the traditional Chinese medical science and is insomnia category。The traditional Chinese medical science is thought, primary disease owing to excessively working with one's mind for a long time, a tax on one's mind, psychentonia, excessive thinking, mood are not relaxed, so that imbalance of YIN and YANG, cloudy blood internal injury, manner virtual loss, brain is become homeless to support and caused being insomnia。Its sick position is at brain, closely related with the heart, liver,spleen,kidney, gallbladder。Its pathogenesis mostly is deficiency of both the heart and spleen, lack of preservation of spirit and malaise。Treatment is with supplementing QI and nourishing YIN, and mind tranquilizing and the heart calming is main。Accordingly, the technical scheme that this invention address that is, this Chinese medicine is made up of the material medicine of following weighing scale: Poria cum Radix Pini 15-20g, Radix Ophiopogonis 12-18g, Semen Ziziphi Spinosae (parched) 20-30g, Arillus Longan 6-9g and Concha Ostreae 20-30g,, add water to submerge by above-mentioned raw materials medicament mixed together, soak 30-60min, intense fire is boiled, and slow fire decocts 20-30min again, filters, obtaining the first filtrate, medicinal residues add water submergence, and intense fire is boiled, slow fire decocts 20-30min again, filters, obtains the second filtrate, merge twice filtrate, mix and get final product。
Chinese medicine of the present invention is applicable to the insomnia that neurasthenia causes, disease is seen: difficulty falling asleep, dreaming often and waking easily, sleep rhythm are disorderly, sleep anesthesia, wake up after without freshness, spiritlessness and weakness, malaise etc., can significantly improve insomnia, determined curative effect, and onset is rapid, take safe and reliable, have no side effect, be the innovation on treatment neurasthenia's insomnia drug。
Detailed description of the invention
Below in conjunction with embodiment, the specific embodiment of the present invention is described in further detail。
Embodiment 1
The present invention in the specific implementation, can be made up of the material medicine of following weighing scale: Poria cum Radix Pini 16g, Radix Ophiopogonis 13g, Semen Ziziphi Spinosae (parched) 21g, Arillus Longan 7g and Concha Ostreae 21g, by above-mentioned raw materials medicament mixed together, adding water to submerge, soak 30-60min, intense fire is boiled, slow fire decocts 20-30min again, filters, obtains the first filtrate, medicinal residues add water submergence, and intense fire is boiled, and slow fire decocts 20-30min again, filter, obtain the second filtrate, merge twice filtrate, mix and get final product。
Embodiment 2
The present invention in the specific implementation, also can be made up of the material medicine of following weighing scale: Poria cum Radix Pini 17g, Radix Ophiopogonis 15g, Semen Ziziphi Spinosae (parched) 25g, Arillus Longan 8g and Concha Ostreae 25g, by above-mentioned raw materials medicament mixed together, adding water to submerge, soak 30-60min, intense fire is boiled, slow fire decocts 20-30min again, filters, obtains the first filtrate, medicinal residues add water submergence, and intense fire is boiled, and slow fire decocts 20-30min again, filter, obtain the second filtrate, merge twice filtrate, mix and get final product。
Embodiment 3
The present invention in the specific implementation, also can be made up of the material medicine of following weighing scale: Poria cum Radix Pini 19g, Radix Ophiopogonis 17g, Semen Ziziphi Spinosae (parched) 29g, Arillus Longan 9g and Concha Ostreae 29g, by above-mentioned raw materials medicament mixed together, adding water to submerge, soak 30-60min, intense fire is boiled, slow fire decocts 20-30min again, filters, obtains the first filtrate, medicinal residues add water submergence, and intense fire is boiled, and slow fire decocts 20-30min again, filter, obtain the second filtrate, merge twice filtrate, mix and get final product。
In said components, wherein:
Poria cum Radix Pini: sweet light, flat。Sweet in the mouth is nontoxic。Enter the heart, spleen channel。Function cures mainly: mind calming, calms the nerves, diuretic。Control palpitation with fear of having a guilty conscience, forgetful, insomnia, infantile convulsion, dysuria。
Radix Ophiopogonis: hardship sweet, micro-, it is slightly cold。GUIXIN, lung, stomach warp。Function with cure mainly: YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire。For dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation。
Semen Ziziphi Spinosae (parched): nature and flavor: sweet is flat。Gui Jing: heart channel；Spleen channel；Liver Channel；Gallbladder meridian。Function: mind tranquilizing and the heart calming；Nourishing the liver；Arresting sweating。Cure mainly: restlessness of asrhenia type and insomnia；Palpitation with fear palpitation with a distress feeling；Body void spontaneous perspiration, night sweat。
Arillus Longan: nature and flavor are warm in nature, taste is sweet。Function cures mainly: invigorating the heart and spleen, nourishing blood to tranquillize the mind。For insufficiency of vital energy and blood, severe palpitation, forgetful insomnia, blood deficiency and yellow complexion。
Concha Ostreae: salty, is slightly cold。Return liver, gallbladder, kidney channel。Tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving, restrain astringent or styptic treatment for spontaneous sweating。For insomnia of palpitating with fear, vertigo and tinnitus, scrofula sucutaneous nodule, note of the ancient Chinese abdominal mass mass in the abdomen, spontaneous sweating, metrorrhagia and leukorrhagia of passing out semen, pantothenic acid of having a stomachache。Concha Ostreae (calcined) convergence is astringent or styptic treatment for spontaneous sweating。For spontaneous sweating, metrorrhagia and leukorrhagia of passing out semen, acid regurgitation of having a stomachache。
Above-mentioned component science, reasonable compatibility, support mutually, Poria cum Radix Pini's invigorating the spleen and benefiting QI in side, mind tranquilizing and the heart calming；Nourishing YIN to relieve dryness Radix Ophiopogonis, lung heat clearing are promoted the production of body fluid；Semen Ziziphi Spinosae (parched) nourishing the liver, mind tranquilizing and the heart calming；Arillus Longan invigorating the heart and spleen, nourish blood and allay excitement；Concha Ostreae convergence is astringent or styptic treatment for spontaneous sweating, tranquillizing and allaying excitement, yin fluid astringing YANG hyperactivity suppressing。All medicines have share supplementing QI and nourishing YIN, the merit of mind tranquilizing and the heart calming。Being effective to treatment neurasthenia's insomnia, good effect, drug safety, and obtain through clinical data and fully prove, relevant clinical data is as follows:
1 clinical data
1.1 case-datas choose out-patient 80 example, are randomly divided into treatment group and each 40 examples of matched group。Wherein, treatment group female 25 example, male 15 examples；32～66 years old age；The course of disease 2～60 months。Matched group female 28 example, male 12 examples；22～65 years old age；The course of disease 2～58 months。Two groups of patients there was no significant difference (P > 0.05) in physical data such as sex, age, the courses of disease through statistical analysis, has comparability。
1.2 diagnostic criterias
1.2.1 diagnostic criteria list of references is formulated: to continue and distressful mental and physical fatiguability, feature can not be reverted to, at least with following 2: 1. emotional symptoms, such as worried nervous irritability etc. through having a rest and entertaining, can there is anxiety-depression, but not account for leading；2. spirit easily Agitation, increases as recalled association, absent minded, and acousto-optic is stimulated sensitivity etc.；3. physiological signs, such as muscle tone pain (headache lumbago and backache etc.)；4. sleep disorder, such as difficulty falling asleep, dreaming often and waking easily, sleep rhythm disorder, sleep anesthesia, wakes up afterwards without freshness etc.；5. psychophysiological disorders, as felt dizzy, tinnitus, nervous, uncomfortable in chest, abdominal distention, dyspepsia, frequent micturition, hyperhidrosis, impotence and premature ejaculation and menoxenia。Above-mentioned symptom continues at least 3 months, and work and study and social communication are caused harmful effect, and patient agonizes or affects social function and actively ask doctor;Get rid of physical disease or organic disease other types neurosis and schizophrenia。
1.2.2 inclusive criteria 1. all cases all meet neurasthenia's diagnostic criteria；2. PSQI scoring > 7 points；3. age 18 years old～75 years old。
Exclusion standard: 1. the age is below 18 one full year of life or 75 one full year of life above person；2. trimester of pregnancy, women breast-feeding their children；3. the severe primary disease patients such as cardiovascular, lung, liver, kidney and hemopoietic system it are associated with；4. psychotic；5. all not by the not congruent judgement person that affects the treatment of regulation medication or data。
2 therapeutic schemes
2.1 matched group deanxit sheets (spirit hundred pharmaceutical Co. Ltds of Denmark produce, medicine quasi-font size H20080175, every 10mg) are oral, each 10mg/d, morning decoction being taken at a draught。
2.2 treatment groups coordinate Chinese medicine of the present invention, each 200-300ml on matched group basis, sooner or later respectively take 1 time。
Strong tea, coffee, pungent stimulation food is avoided during treatment。The course for the treatment of is 4 weeks, observes two groups of curative effects after treatment。
3 observation index and therapeutic evaluation therapeutic effect application PSQI, self rating depressive scale (SDS), Analysisof Self-rating Anxiety Scale (SAS) evaluation, evaluation at the 4th weekend before treatment and after treatment。PSQI is formed 7 factors by 18 entries, and each factor, by 0 point～3 graduation score, accumulates the total score that each factor score is PSQI。Total score is 0 point～21 points, and score is more high, represents that sleep quality is more poor。About sleep comprehensive therapeutic effect evaluation criteria in efficacy evaluation reference Ministry of Public Health new Chinese medicine guideline of clinical investigations。Recovery from illness: PSQI total score deduction rate > 75% after treatment；Effective: PSQI total score deduction rate > 50%；Progressive: PSQI total score deduction rate > 25%；Invalid: total score deduction rate < 25%。
4 statistical method total datas are all through SPSS11.0 software processes, and enumeration data adopts χ2Inspection, ranked data Ridit checks。
5 results
5.1 liang of group patient clinical comparitive study, in Table 1。
1 liang of table group patient clinical comparitive study example
| Group (n) | Recovery from illness | Effective | Progressive | Invalid | Total effective rate |
| Treatment group (40) | 20 | 12 | 6 | 2 | 95% |
| Matched group (40) | 8 | 13 | 11 | 8 | 80% |
As seen from Table 1, in treatment group 40 example patient, 30 examples of fully recovering, effective 12 examples, progressive 6 examples, invalid 2 examples, total effective rate 95%；In matched group 40 example patient, 8 examples of fully recovering, effective 13 examples, progressive 11 examples, invalid 8 examples, total effective rate 80%。Check through Ridit, U=3.35, P=0.0008 < 0.01, have pole significant difference。
Before and after 2.2 liang of group treatments, PSQI, SDS, SAS scoring is compared, in Table 2
Before and after the group treatment of 2 liang of table, (X ± s) [n=40] is compared in PSQI, SDS, SAS scoring
Note: compare * P < 0.05 with before treatment；#P < 0.05 is compared with matched group after treatment
As seen from Table 2, treatment group and matched group PSQI, SDS, SAS diversity of values not statistically significant (P > 0.05) before treatment；After treating 4 weeks, (P < 0.05) all it is obviously improved before two groups of PSQI, SDS, SAS scoring relatively treatments, significantly improve (P < 0.05) after PSQI, SDS, SAS scoring all relatively treatment of control group after the treatment for the treatment of group, illustrate that treatment group can obviously improve PSQI, SDS, SAS scoring。
6 conclusions
To sum up, treatment by Chinese herbs neurasthenia of the present invention has a sleepless night evident in efficacy, there is supplementing QI and nourishing YIN, effect of mind tranquilizing and the heart calming, insomnia can be significantly improved, determined curative effect, and onset is rapid, takes safe and reliable, has no side effect, total effective rate, up to 95%, is the Chinese medicine preparation for the treatment of neurasthenia's insomnia more satisfactory at present。
Claims (4)
1. the Chinese medicine treating neurasthenia's insomnia, it is characterized in that, this Chinese medicine is made up of the material medicine of following weighing scale: Poria cum Radix Pini 15-20g, Radix Ophiopogonis 12-18g, Semen Ziziphi Spinosae (parched) 20-30g, Arillus Longan 6-9g and Concha Ostreae 20-30g, by above-mentioned raw materials medicament mixed together, adding water to submerge, soak 30-60min, intense fire is boiled, slow fire decocts 20-30min again, filtering, obtain the first filtrate, medicinal residues add water submergence, intense fire is boiled, slow fire decocts 20-30min again, filters, obtains the second filtrate, merge twice filtrate, mix and get final product。
2. the Chinese medicine for the treatment of neurasthenia's insomnia according to claim 1, it is characterized in that, be made up of the material medicine of following weighing scale: Poria cum Radix Pini 16g, Radix Ophiopogonis 13g, Semen Ziziphi Spinosae (parched) 21g, Arillus Longan 7g and Concha Ostreae 21g, by above-mentioned raw materials medicament mixed together, adding water to submerge, soak 30-60min, intense fire is boiled, slow fire decocts 20-30min again, filtering, obtain the first filtrate, medicinal residues add water submergence, intense fire is boiled, slow fire decocts 20-30min again, filters, obtains the second filtrate, merge twice filtrate, mix and get final product。
3. the Chinese medicine for the treatment of neurasthenia's insomnia according to claim 1, it is characterized in that, be made up of the material medicine of following weighing scale: Poria cum Radix Pini 17g, Radix Ophiopogonis 15g, Semen Ziziphi Spinosae (parched) 25g, Arillus Longan 8g and Concha Ostreae 25g, by above-mentioned raw materials medicament mixed together, adding water to submerge, soak 30-60min, intense fire is boiled, slow fire decocts 20-30min again, filtering, obtain the first filtrate, medicinal residues add water submergence, intense fire is boiled, slow fire decocts 20-30min again, filters, obtains the second filtrate, merge twice filtrate, mix and get final product。
4. the Chinese medicine for the treatment of neurasthenia's insomnia according to claim 1, it is characterized in that, be made up of the material medicine of following weighing scale: Poria cum Radix Pini 19g, Radix Ophiopogonis 17g, Semen Ziziphi Spinosae (parched) 29g, Arillus Longan 9g and Concha Ostreae 29g, by above-mentioned raw materials medicament mixed together, adding water to submerge, soak 30-60min, intense fire is boiled, slow fire decocts 20-30min again, filtering, obtain the first filtrate, medicinal residues add water submergence, intense fire is boiled, slow fire decocts 20-30min again, filters, obtains the second filtrate, merge twice filtrate, mix and get final product。
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101549085A (en) * | 2008-04-03 | 2009-10-07 | 北京中科仁和科技有限公司 | Traditional Chinese medicine for treating neurasthenia and preparation method thereof |
| CN104189444A (en) * | 2014-08-07 | 2014-12-10 | 张长虹 | Orally-taken traditional Chinese medicine for treating insomnia |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101549085A (en) * | 2008-04-03 | 2009-10-07 | 北京中科仁和科技有限公司 | Traditional Chinese medicine for treating neurasthenia and preparation method thereof |
| CN104189444A (en) * | 2014-08-07 | 2014-12-10 | 张长虹 | Orally-taken traditional Chinese medicine for treating insomnia |
Non-Patent Citations (1)
| Title |
|---|
| 刘广余等: "眠而康口服液镇静催眠作用的实验研究", 《南京医科大学学报》 * |
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