CN105687696B - Improve Chinese medicine composition and its application of chemotherapy in ovarian cancer sensibility - Google Patents
Improve Chinese medicine composition and its application of chemotherapy in ovarian cancer sensibility Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
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Abstract
The invention discloses a kind of Chinese medicine composition for improving chemotherapy in ovarian cancer sensibility and its applications, and in parts by weight, formula includes: 2-4 parts of Rehmannia glutinosa, Radix Ophiopogonis 0.5-1.5 part, and 0.5-1.5 parts of Schisandra chinensis.The present invention can enhance chemotherapy in ovarian cancer sensibility, reduce the effect of chemotherapy side effect, the body of patient can be nourished again, and reduce various side effects and adverse reaction caused by radiotherapy, and Chinese medicine toxic side effect used is small, raw material is simple and easy to get, convenient to take, and the body and economic pressures to patient all greatly reduce.The present invention can be prepared by Modern preparations method improves chemotherapy in ovarian cancer sensitive drug, is combined with Western medicine and tumor chemical therapy, enhances the curative effect of tumor chemical therapy.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition of adjuvant therapy chemotherapy, especially a kind of auxiliary improves ovary cancerization
Treat the Chinese medicine composition of sensibility.
Background technique
Ovarian epithelial carcinoma (hereinafter referred to as oophoroma) is the highest tumour of the death rate in gynecologic malignant tumor.Advanced stage at present
Treatment of ovarian cancer method is mainly cytoreductive art and postoperative chemotherapy, although First-line chemotherapy reactivity (RR) can reach 60%-
80%, wherein still there is 55%-75% patient's recurrence in 1-2 after treatment.Survival rate is very low within 5 years, gynecological tumor doctor still face
Face acid test.Chemotherapy resistance is the main reason for influencing human ovarian cancer patients' survival rate.
Chinese medicine plays the role of enhanced sensitivity, synergy, attenuation in the treatment of tumour, and the research of reversing tumor cells resistance has taken
Achievement centainly is obtained, there is important theory and practical value.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition for improving chemotherapy in ovarian cancer sensibility, both can be enhanced
The curative effect for the treatment of, and have certain female health effect, to reduce various side effects and adverse reaction caused by radiotherapy.
Another object of the present invention is that above-mentioned Chinese medicine composition is applied to preparation to improve chemotherapy in ovarian cancer sensibility
On drug.
The object of the present invention is achieved like this: a kind of Chinese medicine composition improving chemotherapy in ovarian cancer sensibility, feature
Be: in parts by weight, formula includes: 2-4 parts of Rehmannia glutinosa, Radix Ophiopogonis 0.5-1.5 part, and 0.5-1.5 parts of Schisandra chinensis.
In parts by weight, formula includes: 2.5-3.5 parts of Rehmannia glutinosa, Radix Ophiopogonis 0.8-1.2 part, Schisandra chinensis 0.8-1.2
Part.
In parts by weight, formula includes: 3 parts of Rehmannia glutinosa, 1 part of Radix Ophiopogonis, 1 part of Schisandra chinensis.
The Rehmannia glutinosa, Radix Ophiopogonis, Schisandra chinensis are weighed by formulation ratio, are ground into coarse powder, with water boiling and extraction 2-3 times,
Each plus water amount is that 5-15 times of medicinal material is measured, and boils extraction 1-3 hours, and combined extract filtering evaporation and concentration arrives relative density
It is 1.10/80 DEG C -1.30/80 DEG C, obtains water and extract medicinal extract.
The Chinese medicine composition improves the application in chemotherapy in ovarian cancer sensitive drug in preparation.
The dosage form of the described raising chemotherapy in ovarian cancer sensitive drug be decoction, pill, powder, paste, sublimed preparation, vina,
Syrup, extract, pastille, distillate medicinal water, jelly, medicinal tea, nail agent, stylus, suppository, herbal leaven, paste, cake agent, wash liniment, finish,
Line agent, medicated roll, press agent, toast agent, fumicants, medicine perfume, soft extract, tablet, electuary, bagged instant preparation, oral solutions, capsule, pill,
Mixture, tincture, aerosol, enema, film, eye-drops preparations, nasal formulations, sponginum or injection.
The dosage form of the raising chemotherapy in ovarian cancer sensitive drug is peroral dosage form.
The present invention can enhance chemotherapy in ovarian cancer sensibility, reduce the effect of chemotherapy side effect, and can nourish the body of patient
Body, and various side effects and adverse reaction caused by radiotherapy are reduced, and Chinese medicine toxic side effect used is small, raw material is simply easy
, convenient to take, body and economic pressures to patient all greatly reduce.The present invention can be prepared into raising by Modern preparations method
Chemotherapy in ovarian cancer sensitive drug is combined with Western medicine and tumor chemical therapy, enhances the curative effect of tumor chemical therapy.
Detailed description of the invention
Fig. 1 is the oophoroma cisplatin chemotherapy enhanced sensitivity experimental data figure of 3 gained medicinal extract of the embodiment of the present invention, and wherein ordinate is
Ovarian cancer cell survival rate, abscissa are administration concentration (unit mg/ml).
Specific embodiment
The present invention is a kind of Chinese medicine composition for improving chemotherapy in ovarian cancer sensibility, and in parts by weight, formula includes:
2-4 parts of Rehmannia glutinosa, Radix Ophiopogonis 0.5-1.5 part, 0.5-1.5 parts of Schisandra chinensis.More preferably, in parts by weight, formula includes: ripe
2.5-3.5 parts of glutinous rehmannia, Radix Ophiopogonis 0.8-1.2 part, 0.8-1.2 parts of Schisandra chinensis.Most preferably, in parts by weight, formula includes:
3 parts of Rehmannia glutinosa, 1 part of Radix Ophiopogonis, 1 part of Schisandra chinensis.
Rehmannia glutinosa, Radix Ophiopogonis, Schisandra chinensis are weighed by formulation ratio, are ground into coarse powder, with water boiling and extraction 2-3 times, are added every time
The amount of water is that 5-15 times of medicinal material is measured, and boils extraction 1-3 hours, and combined extract filtering, which is concentrated by evaporation to relative density, is
It 1.10/80 DEG C -1.30/80 DEG C, obtains water and extracts medicinal extract.
In we, Rehmannia glutinosa is scrophulariaceae rehmannia glutinosa plant Rehm, and the dry of annia glutinosa Libosch. processes
Root tuber.It is sweet in flavor；It is warm-natured.Return liver；Kidney channel.With enrich blood moist, the effect of beneficial to spirit and marrow；For blood deficiency chlorosis, dizziness palpitaition, liver
Kidney yin is lost, hectic fever night sweat, infertility, irregular menstruation, metrostaxis, the symptoms such as soreness and weakness of waist and knees.Chinese medicine Rehmannia glutinosa is clinical normal
With key medicine of enriching blood, there is the effect of negative blood body fluid for the treatment of loses all diseases.Research shows that glutinous rehmannia has adjustment effect to immune system, with
Safeguard that the stabilization of body, leucocyte increment rate are 18% or so.
Radix Ophiopogonis is the root tuber of liliaceous plant Radix Ophiopogonis Ophiopogon japonicus (L.f.) KerGawl..It is sweet in flavor,
Slight bitter；Cold nature.Return heart, lung, stomach meridian.With nourishing Yin and promoting production of body fluid, the effect of moistening lung and clearing away the heart-fire.For dryness of the lung dry cough.Tuberculosis cough, saliva
Wound is thirsty, vexed insomnia, Heat Diabetes, dry constipation of intestines；The symptoms such as pharyngeal diphtheria.
Schisandra chinensis is the drying and ripening of magnoliaceae schisandra Schisandra chinensis (Turcz.) Baill.
Fruit.It is sour, sweet, it is warm-natured.Return lung, the heart, kidney channel.With astringency inducing, the effect of supplementing qi and promoting the production of body fluid, tonifying kidney and calming nerves.It is usually used in long
Void of coughing asthma, emission, enuresis frequent micturition, endless diarrhea, spontaneous sweating, injury thirst, Heat Diabetes, palpitation and insomnia.
Theory of traditional Chinese medical science thinks: " Plain Questions ancient times innocence opinion " points out husband seven or eight, and irritability declines, and muscle is not active.Menopause, essence
Few, kidney declines, body all pole.Woman seventy-seven, and conception vessel is empty, and taichong channel declines few, the menopause, menostasia.The failure of visible human body
Mainly related to the deficiency of vital energy and blood of liver kidney, Difficult Classic also notes that: " respiratory function is concerned with the heart and lung sucks liver and kidney ", and liver kidney is burnt with subordinate,
" Plain Questions seek hygienic meeting " is pointed out: " defensive QI going out from lower-JIAO ", what the sun unified body defends gas, plays the function of resisting exopathogen.Thus again
Absolutely prove liver and kidney qi blood for the important function of bodily fuctions' prosperity and decline.
Qing Dynasty's YE Tian shi proposes " the woman is based on the liver ", illustrates that the physiology of liver and women, pathological relation are extremely close.Liver
Main store blood, married woman are to use with blood, and warp, pregnant, production, cream are invariably with blood for this, therefore Qing Dynasty Chen Xiuyuan mentions in " female section main idea "
" Gai Jingshui is that leading for yin of fainting is appointed in punching " out.And The liver and the kidney have a common source, yi and Kui are derived from the same origin, it is seen that the Sheng of filling of liver and kidney qi blood is female pathology
Basis.
Rehmannia glutinosa obtains native special essence in we, color it is black enter kidney, tonifying kidney and benefiting sperm；Radix Ophiopogonis, cool drop lung was moisturized, lung governing coordinative activities of viscera, towards hundred
Arteries and veins, lung is golden must to drop the then Lishui Jin Sheng, and the qi and blood of liver kidney is naturally sufficient, and Schisandra chinensis receives QI of five ZANG-organs and returns kidney, and sending down abnormally ascending is calmed the nerves, and is cooperated ripe
The town Di Zhuanshui sun, the change source of cooperation Radix Ophiopogonis enhancing lung further strengthen the power of lower burnt liver and kidney qi blood metaplasia.Three medicines are solved with using
The yin point of heat formation from yin deficiency, the i.e. reason of " water shallowly do not support dragon ", beneficial soil fills up Kidney-Yin, draws yang pathogens and playbacks, and flavour of a drug sour-sweet herbs nourishing yin, first oneself
Change soil, enhance the gas-liquid of soil and without staying greasy disadvantage.Therefore the present invention enhances female reproductive system function by reinforcing liver and kidney qi blood
Healthy tendency reduces chemotherapy side effect to play the role of enhancing chemotherapy in ovarian cancer sensibility.
Above-mentioned Chinese medicine composition preparation improve chemotherapy in ovarian cancer sensitive drug in application, by with allow be added
Pharmaceutical auxiliary material mixing, can be made into corresponding dosage form using conventional method.Improve the dosage form of chemotherapy in ovarian cancer sensitive drug
It can are as follows: decoction, pill (honeyed bolus, the water-bindered pill, starched pill, wax-wrapped pill, condensed pill), powder, paste (cream taste, ointment, plaster), sublimed preparation, wine
Agent, extract, pastille, distillate medicinal water, jelly, medicinal tea, nail agent, stylus, suppository, herbal leaven, paste, cake agent, washes liniment, oil at syrup
Agent, medicated roll (fuse), presses agent, toast agent, fumicants, medicine perfume (or spice) etc., soft extract, tablet, electuary, bagged instant preparation, oral solution at line agent (medicated thread)
Agent, capsule, pill, mixture, tincture, aerosol, enema, film (membrane agent), eye-drops preparations (eyewash, eye drops,
Ophthalmic ointment), nasal formulations (nasal drop, nasal spray), sponginum (sterilizing hemostasis), the dosage forms such as injection.The present invention preferentially selects
Peroral dosage form, such as soft extract, tablet, capsule, vina, medicinal tea, electuary, bagged instant preparation, the dosage forms such as mixture.
Below by way of specific example, the present invention is further elaborated, but the present invention is not limited thereto specific examples.
Embodiment 1
0.3 kilogram of Rehmannia glutinosa, 0.1 kilogram of Radix Ophiopogonis, 0.1 kilogram of Schisandra chinensis is weighed respectively.Rehmannia glutinosa, Radix Ophiopogonis, Schisandra chinensis are equal
It is ground into coarse powder, with water boiling and extraction 3 times, every time plus the amount of water is 5 times of amounts of medicinal material, boils extraction 1 hour.Combined extract
It is 1.10/80 DEG C~1.30/80 DEG C that filtering, which is concentrated by evaporation to relative density, obtains medicinal material water and extracts medicinal extract.
Embodiment 2
Weigh 3 kilograms of Rehmannia glutinosa, 1 kilogram of Radix Ophiopogonis, 1 kilogram of Schisandra chinensis.Rehmannia glutinosa, Radix Ophiopogonis, Schisandra chinensis are ground into coarse powder,
With water boiling and extraction 3 times, every time plus the amount of water is 10 times of amounts of medicinal material, boils extraction 2 hours.Combined extract filtering evaporation is dense
Being reduced to relative density is 1.10/80 DEG C~1.30/80 DEG C, obtains medicinal material water and extracts medicinal extract.
Embodiment 3
Weigh 6 kilograms of Rehmannia glutinosa, 2 kilograms of Radix Ophiopogonis, 2 kilograms of Schisandra chinensis.Rehmannia glutinosa, Radix Ophiopogonis, Schisandra chinensis are ground into coarse powder,
With water boiling and extraction 3 times, every time plus the amount of water is 15 times of amounts of medicinal material, boils extraction 3 hours.Combined extract filtering evaporation is dense
Being reduced to relative density is 1.10/80 DEG C~1.30/80 DEG C, obtains medicinal material water and extracts medicinal extract.
Embodiment 4
Weigh 12 kilograms of Rehmannia glutinosa, 3 kilograms of Radix Ophiopogonis, 3 kilograms of Schisandra chinensis.Rehmannia glutinosa, Radix Ophiopogonis, Schisandra chinensis are ground into slightly
Powder, the amount with water boiling and extraction 3 times, the 1st time plus water are 15 times of amounts of medicinal material, boil extraction 3 hours, the 2nd, 3 time plus the amount of water
For 10 times of amounts of medicinal material, boils and extract 2h.It is 1.10/80 DEG C~1.30/ that combined extract filtering, which is concentrated by evaporation to relative density,
It 80 DEG C, obtains medicinal material water and extracts medicinal extract.
Embodiment 5
Weigh 2 kilograms of Rehmannia glutinosa, 0.5 kilogram of Radix Ophiopogonis, 0.5 kilogram of Schisandra chinensis.Rehmannia glutinosa, Radix Ophiopogonis, Schisandra chinensis are ground into
Coarse powder, with water boiling and extraction 3 times, every time plus the amount of water is 10 times of amounts of medicinal material, boils extraction 2 hours.Combined extract filtering
Being concentrated by evaporation relative density is 1.10/80 DEG C~1.30/80 DEG C, obtains medicinal material water and extracts medicinal extract.
Embodiment 6
Weigh 4 kilograms of Rehmannia glutinosa, 1.5 kilograms of Radix Ophiopogonis, 1.5 kilograms of Schisandra chinensis.Rehmannia glutinosa, Radix Ophiopogonis, Schisandra chinensis are ground into
Coarse powder, with water boiling and extraction 3 times, every time plus the amount of water is 10 times of amounts of medicinal material, boils extraction 2 hours.Combined extract filtering
Being concentrated by evaporation relative density is 1.10/80 DEG C~1.30/80 DEG C, obtains medicinal material water and extracts medicinal extract.
The experiment of oophoroma cisplatin chemotherapy enhanced sensitivity
After the passage for 24 hours of ovarian cancer cell skov cell, logarithmic growth phase cell plants 96 orifice plates.Cell concentration is adjusted to 5
× 104, every 100 μ l of hole (cell number is 5.0 × 103), and every group is given same dose chemotherapeutics: 40mg cis-platinum.
Constant volume dilution is carried out with 3 gained medicinal extract of embodiment, each administration concentration does 6 multiple holes.It is put into 37 DEG C, volume fraction
The incubator culture incubator culture of 5%CO2, saturated humidity.Add 11 μ l of 5g/L MTT solution before measurement 4h every time, puts back to 37 DEG C, body
Fraction 5%CO2, saturated humidity incubator continue to cultivate.After 4h, every hole supernatant liquid is carefully sucked, adds 100 μ l analysis
Pure DMSO solution shakes 10min.M550 microplate reader measures the absorbance in every hole under 570nm wavelength.Not to be added to the present invention
The survival rate of the blank control group of 3 extracting solution of embodiment is 1 to calculate, the results showed that ovarian cancer cell skov is real to the present invention
Survival rate is gradually reduced after applying 3 extracting solution of example, as shown in Figure 1.
Conclusion: the present invention can effectively increase the chemosensitivity of ovarian cancer cell skov, with Western medicine and tumour chemistry
(such as cis-platinum) combination is treated, the curative effect of tumor chemical therapy can be enhanced.
Claims (6)
1. a kind of Chinese medicine composition improves the application in chemotherapy in ovarian cancer sensitive drug in preparation, it is characterised in that: in described
In parts by weight, formula is by 2-4 parts of Rehmannia glutinosa, and Radix Ophiopogonis 0.5-1.5 part, 0.5-1.5 parts of Schisandra chinensis form for drug composition.
2. application according to claim 1, it is characterised in that: Chinese medicine composition in parts by weight, is formulated by radix rehmanniae preparata
It is 2.5-3.5 parts yellow, Radix Ophiopogonis 0.8-1.2 part, 0.8-1.2 parts of Schisandra chinensis compositions.
3. application according to claim 1, it is characterised in that: Chinese medicine composition in parts by weight, is formulated by radix rehmanniae preparata
It is 3 parts yellow, 1 part of Radix Ophiopogonis, 1 part of Schisandra chinensis composition.
4. application according to claim 1,2 or 3, it is characterised in that: the Rehmannia glutinosa, Radix Ophiopogonis, Schisandra chinensis is by formula
Proportion weighs, and is ground into coarse powder, and with water boiling and extraction 2-3 times, each plus water amount is that 5-15 times of medicinal material is measured, and boils and extracts 1-
3 hours, it was 1.10/80 DEG C -1.30/80 DEG C that combined extract filtering, which is concentrated by evaporation to relative density, obtains water and extracts medicinal extract.
5. application according to claim 1, it is characterised in that: the dosage form of the raising chemotherapy in ovarian cancer sensitive drug
For decoction, pill, paste, vina, syrup, medicinal tea, tablet, electuary, bagged instant preparation, oral solutions, capsule, pill or needle
Agent.
6. application according to claim 1, it is characterised in that: the dosage form of the raising chemotherapy in ovarian cancer sensitive drug
For peroral dosage form.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101450198A (en) * | 2008-12-30 | 2009-06-10 | 徐艺峰 | Traditional Chinese medicine preparation mated with radiotherapy and chemotherapy |
| CN101985011A (en) * | 2010-07-19 | 2011-03-16 | 孙一凡 | Blackening powder for grey hairs |
| CN104324356A (en) * | 2014-11-28 | 2015-02-04 | 李福荣 | Traditional Chinese medicine for treating deficiency of qi and yin after ovarian cancer chemotherapy |
| CN104857271A (en) * | 2014-10-14 | 2015-08-26 | 磐安县道地磐药中药研究所 | Traditional Chinese medicine decoction piece combination preparation enhancing body immunity, preparation method therefor and combination package |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101450198A (en) * | 2008-12-30 | 2009-06-10 | 徐艺峰 | Traditional Chinese medicine preparation mated with radiotherapy and chemotherapy |
| CN101985011A (en) * | 2010-07-19 | 2011-03-16 | 孙一凡 | Blackening powder for grey hairs |
| CN104857271A (en) * | 2014-10-14 | 2015-08-26 | 磐安县道地磐药中药研究所 | Traditional Chinese medicine decoction piece combination preparation enhancing body immunity, preparation method therefor and combination package |
| CN104324356A (en) * | 2014-11-28 | 2015-02-04 | 李福荣 | Traditional Chinese medicine for treating deficiency of qi and yin after ovarian cancer chemotherapy |
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