CN101450198A - Traditional Chinese medicine preparation mated with radiotherapy and chemotherapy - Google Patents
Traditional Chinese medicine preparation mated with radiotherapy and chemotherapy Download PDFInfo
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- CN101450198A CN101450198A CNA2008102425956A CN200810242595A CN101450198A CN 101450198 A CN101450198 A CN 101450198A CN A2008102425956 A CNA2008102425956 A CN A2008102425956A CN 200810242595 A CN200810242595 A CN 200810242595A CN 101450198 A CN101450198 A CN 101450198A
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Abstract
The invention relates to a Chinese medical preparation that is used with radiation and chemotherapy. The preparation is a composition that is prepared from 30 granule shape concentration Chinese medicaments including: 20-30 parts by weight of angelica, 20-30 parts by weight of radix pseudostell, 20-30 parts by weight of rehmanniae vaporata, 20-30 parts by weight of cornus, 20-30 parts by weight of poria, 20-30 parts by weight of raw seed of jog's tears, 20-30 parts by weight of galli stomachichum corium, 20-30 parts by weight of cyperus rotundus, 20-30 parts by weight of americanwater plantain, 20-30 parts by weight of cortex moutan, 20-30 parts by weight of asparagus, 20-30 parts by weight of liriope, 20-30 parts by weight of rhizoma pardis, 20-30 parts by weight of donkey hide gelatin, 20-30 parts by weight of aweto, 20-30 parts by weight of dried green orange peel, 20-30 parts by weight of bamboo shavings, 20-30 parts by weight of morinda officinalis, 20-30 parts by weight of rhizoma dioscoreae, 20-30 parts by weight of curcuma, 20-30 parts by weight of bupleurum, 20-30 parts by weight of suberect spatholobus stem, 20-30 parts by weight of radix adenophorea, 20-30 parts by weight of red ginseng, 20-30 parts by weight of bitter orange, 20-30 parts by weight of fructus gardeniae, 20-30 parts by weight of curcuma, 5-10 parts by weight of schisandra, 5-10 parts by weight of saffron and 5-10 parts by weight of tangerine peel. The granule shape concentration Chinese medicaments have same concentration ratio by weight (for example 5:1). The Chinese medical preparation can interdict side effect of radiation and chemotherapy, assistant recover immune function, patient can accept radiation and chemotherapy continuously with any dosage and period, increase efficiency, improve curative ratio of malignancy, reduce recurernce rate and provide possibility for prolonging lifetime of malignancy patient and using radiation and chemotherapy efficiently.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation that is used with radiotherapy, chemotherapy.
Background technology
The universal method of the various cancers of treatment is excisions and is aided with chemotherapy and/or radiotherapy at present, perhaps only uses chemotherapy and/or radiotherapy.But, because of radiation and chemotherapy all can cause damage to the normal organ of human body, and in the radiotherapy, chemotherapy process, the various symptoms that also can occur, as anemia, pain, weakness, feel sick, vomiting, alopecia, cardiopalmus, insomnia, anxiety, do not take food, side effect such as agitation, fear, erythrocyte, leukocyte, three main indexs of platelet descend rapidly and can't recover simultaneously, therefore, radiotherapy and/or chemotherapy often need interrupting or stopping, wait for after the human immune system recovers and proceeding.But, because fast approximately 10 times of the resume speeds of cancerous cell than human immune system resume speed, have cancer cell regeneration again in interruption radiotherapy and/or chemotherapeutic period, so, be interrupted and carry out radiation and chemotherapy and not only fail kill cancer cell, cause the destruction of immune function of human body on the contrary, also become one of immediate cause of cancer patient's high mortality.
Summary of the invention
The objective of the invention is: the Chinese medicine preparation that provides a kind of and radiotherapy, chemotherapy to be used, it can block radiotherapy, chemical therapy toxic side effect, the auxiliary immune function of human body that recovers, often the phase is carried out prolongation cancer patient's life continuously to make radiotherapy, chemotherapy.
The technical scheme that realizes the object of the invention is: a kind of Chinese medicine preparation that is used with radiotherapy, chemotherapy, and it is by following 30 kinds of compound recipes that the graininess concentrated traditional Chinese medicine is formed, and each graininess concentrated traditional Chinese medicine consumption is as follows by weight:
Radix Angelicae Sinensis 20～30, Radix Pseudostellariae 20～30, Radix Rehmanniae Preparata 20～30,
Fructus Corni 20～30, Poria 20～30 is given birth to Semen Coicis 20～30,
Endothelium Corneum Gigeriae Galli 20～30, Rhizoma Cyperi 20～30, Rhizoma Alismatis 20～30,
Cortex Moutan 20～30, Radix Asparagi 20～30, Radix Ophiopogonis 20～30,
Rhizoma Paridis 20～30, Colla Corii Asini 20～30, Cordyceps 20～30,
Pericarpium Citri Reticulatae Viride 20～30, Caulis Bambusae In Taenia 20～30, Radix Morindae Officinalis 20～30,
RHIIZOMA DIOSCOREAE frOm Henan of China 20～30, Radix Curcumae 20～30, Radix Bupleuri 20～30,
Caulis Spatholobi 20～30, Radix Adenophorae (Radix Glehniae) 20～30, Radix Ginseng Rubra 20～30,
Fructus Aurantii 20～30, SHANZHIZI 20～30, Rhizoma Curcumae 20～30,
Fructus Schisandrae Chinensis 5～10, Stigma Croci 5～10, Pericarpium Citri Reticulatae 5～10;
Described each graininess concentrated traditional Chinese medicine cocnentration factor by weight is identical.
In the above-mentioned Chinese medicine preparation, described graininess concentrated traditional Chinese medicine cocnentration factor by weight is: the ratio of the graininess concentrated traditional Chinese medicine weight that raw materials used weight and raw material with this weight obtain; Described raw material is meant the raw material of Chinese medicine medicine (be crude Chinese medicine, also claim to give birth to Chinese medicine) or the prepared slices of Chinese crude drugs (promptly through single medicinal material preliminary working, that sell in the pharmacy, also claiming ripe Chinese medicine).
In the above-mentioned Chinese medicine preparation, described graininess concentrated traditional Chinese medicine cocnentration factor by weight is 5:1.
The dosage form of above-mentioned Chinese medicine preparation is an oral granule type Chinese medicine preparation.
Technique effect of the present invention is: Chinese medicine preparation of the present invention is the reason that adopts " disease of dispelling tissue regeneration promoting " according to the Chinese medicine and pharmacy principle, with invigorating vital QI, strong spleen nourishing kidney, assistant is with blood circulation promoting and blood stasis dispelling, as the foundation of combination compound recipe, but not simply improves the simple function of immunity.In its compound recipe: Radix Angelicae Sinensis, Radix Pseudostellariae, Poria, Endothelium Corneum Gigeriae Galli, Colla Corii Asini, living Semen Coicis and Pericarpium Citri Reticulatae have invigorating the spleen for dissipating phlegm, dispersing the stagnated liver-QI for regulating the stomach, and the toxin expelling heat clearing away, regulating functional activities of qi, damp eliminating is separated dry, and tonifying liver is grown the function of stomach; The slow-witted benefit though Rhizoma Cyperi, SHANZHIZI, Radix Curcumae, Radix Bupleuri and Fructus Aurantii are mended, medicine get agile flat be main; The liver that Cortex Moutan, Rhizoma Paridis, Pericarpium Citri Reticulatae Viride, Radix Asparagi, Radix Ophiopogonis, Cordyceps, Fructus Schisandrae Chinensis, Radix Ginseng Rubra and Caulis Bambusae In Taenia cause because of radiotherapy, chemotherapeutic toxicity infringement for detoxifcation, nourishing negative and positive, heart tonifying the liver benefiting, activation, the organic damage of renal function; Radix Rehmanniae Preparata, Fructus Corni, Rhizoma Alismatis and RHIIZOMA DIOSCOREAE frOm Henan of China have YIN nourishing to consolidate, recover the function of the cloudy smart demutation of kidney; Radix Morindae Officinalis, Stigma Croci, Caulis Spatholobi, Radix Adenophorae (Radix Glehniae) and Rhizoma Curcumae have the function of YANG invigorating blood stasis dispelling, and all medicines are also with playing neat effect altogether.Therefore, Chinese medicine preparation of the present invention has blocking-up radiotherapy, chemical therapy toxic side effect, the auxiliary effect that recovers immune function of human body.Clinical practice proves; Be used compound Chinese medicinal preparation of the present invention, the patient can accept to reach heavy dose of radiotherapy, the chemotherapy of 12 times (by every month once) continuously, and need not interruption or stop radiotherapy or chemotherapy, final cure rate is up to 98% or more and avoided single radiotherapy, the chemotherapy difficult problem of recurrence once more after a year, and having solved can't heavy dose, carry out the difficult problem of radiotherapy, chemotherapy continuously, for a long time! Greatly improved cancer patient's survival rate.
The specific embodiment
Below in conjunction with embodiment the present invention is further described, but is not limited to this.
Embodiment 1 preparation Chinese medicine preparation A of the present invention
When preparing Chinese medicine preparation of the present invention, all carry out in the factory that obtains the GMP authentication, production method is all undertaken by the existing mode of production that meets the GMP authentication requesting, and concrete steps are as follows:
1. weigh the following 30 kinds of raw material of Chinese medicine medicines or the prepared slices of Chinese crude drugs respectively: Radix Angelicae Sinensis, Radix Pseudostellariae, Radix Rehmanniae Preparata, Fructus Corni, Poria, give birth to Semen Coicis, Endothelium Corneum Gigeriae Galli, Rhizoma Cyperi, Rhizoma Alismatis, Cortex Moutan, Radix Asparagi, Radix Ophiopogonis, Rhizoma Paridis, Colla Corii Asini, Cordyceps, Pericarpium Citri Reticulatae Viride, Caulis Bambusae In Taenia, Radix Morindae Officinalis, RHIIZOMA DIOSCOREAE frOm Henan of China, Radix Curcumae, Radix Bupleuri, Caulis Spatholobi, Radix Adenophorae (Radix Glehniae), Radix Ginseng Rubra, Fructus Aurantii, SHANZHIZI, Rhizoma Curcumae, Fructus Schisandrae Chinensis, each 250Kg of Stigma Croci and Pericarpium Citri Reticulatae, extract by the existing mode of production that meets the GMP authentication requesting respectively then, concentrate, dry, make 30 kinds of graininess concentrated traditional Chinese medicines of each 50Kg respectively, its cocnentration factor is 5:1 (weight ratio);
2. weigh 30 kinds of graininess concentrated traditional Chinese medicines that 1. step makes respectively, wherein Radix Angelicae Sinensis, Radix Pseudostellariae, Radix Rehmanniae Preparata, Fructus Corni, Poria, give birth to Semen Coicis, Endothelium Corneum Gigeriae Galli, Rhizoma Cyperi, Rhizoma Alismatis, Cortex Moutan, Radix Asparagi, Radix Ophiopogonis, Rhizoma Paridis, Colla Corii Asini, Cordyceps, Pericarpium Citri Reticulatae Viride, Caulis Bambusae In Taenia, Radix Morindae Officinalis, RHIIZOMA DIOSCOREAE frOm Henan of China, Radix Curcumae, Radix Bupleuri, Caulis Spatholobi, Radix Adenophorae (Radix Glehniae), Radix Ginseng Rubra, Fructus Aurantii, SHANZHIZI and Rhizoma Curcumae, by every part of 1Kg, respectively weigh 30 parts, amount to 810Kg, Fructus Schisandrae Chinensis, Stigma Croci and Pericarpium Citri Reticulatae, by every part of 1Kg, respectively weigh 10 parts, amount to 30Kg, then, put into the blender mix homogeneously;
3. the mixture that 2. step is made is gone in the vacuum bag by 30g one is packed, after sealing, sterilization, the sterilization, makes oral granule type Chinese medicine preparation A of the present invention.
Embodiment 2 preparations Chinese medicine preparation B of the present invention
Preparation process is basic identical with embodiment 1, make oral granule type Chinese medicine preparation B of the present invention, difference is the quantity difference of 30 kinds of graininess concentrated traditional Chinese medicines 1. making of step that 2. step is weighed, wherein Radix Angelicae Sinensis, Radix Pseudostellariae, Radix Rehmanniae Preparata, Fructus Corni, Poria, give birth to Semen Coicis, Endothelium Corneum Gigeriae Galli, Rhizoma Cyperi, Rhizoma Alismatis, Cortex Moutan, Radix Asparagi, Radix Ophiopogonis, Rhizoma Paridis, Colla Corii Asini, Cordyceps, Pericarpium Citri Reticulatae Viride, Caulis Bambusae In Taenia, Radix Morindae Officinalis, RHIIZOMA DIOSCOREAE frOm Henan of China, Radix Curcumae, Radix Bupleuri, Caulis Spatholobi, Radix Adenophorae (Radix Glehniae), Radix Ginseng Rubra, Fructus Aurantii, SHANZHIZI and Rhizoma Curcumae, by every part of 1Kg, respectively weigh 20 parts, amount to 540Kg; Fructus Schisandrae Chinensis, Stigma Croci and Pericarpium Citri Reticulatae by every part of 1Kg, respectively weigh 5 parts, amount to 15Kg.
Chinese medicine preparation of the present invention is not subjected to the restriction of embodiment, according to actual needs, can be by the concrete steps of embodiment 1, by in the scope of 30 kinds of graininess concentrated traditional Chinese medicine consumptions of described composition compound recipe, change the product of the consumption production various dose of 30 kinds of graininess concentrated traditional Chinese medicines, to adapt to different patients' needs.
Application example
The Chinese medicine preparation of the present invention that Application Example makes carries out clinical practice to all kinds of cancer patients that needs carry out radiotherapy and/or chemotherapy;
(1) clinical practice concrete condition:
1. treatment group: 200 people (comprising all kinds of cancer patients that perform the operation and do not undergo surgery) are carrying out radiotherapy, chemotherapeutic period, the cancer patient is by early, middle and late each clothes every day, every clothes 30g, taking medicine before meal is used, the preparation that takes traditional Chinese medicine is according to cancer patient's situation and radiotherapy, chemotherapy dosage by the doctor, the Chinese medicine preparation A or the B that select embodiment 1 or embodiment 2 to make, or the Chinese medicine preparation of the present invention of other various dose that make according to actual needs; It is synchronous with radiotherapy, chemotherapy to take medicine, until radiotherapy, end of chemotherapy (being about most needs a year);
2. matched group 1:100 people only carries out chemotherapy and radiation after the operation;
3. matched group 2:100 people, with perform the operation the back chemotherapy and radiation with take other and rise leukocyte agent (promptly only having the medicine that rises the leukocyte simple function) and carry out synchronously;
Assessment method: after each radiotherapy, the chemotherapy, detect erythrocyte, leukocyte, platelet; The CT sheet of taking pictures; Detect biochemical indicator;
According to the CT sheet, the evaluation tumor cure rate;
According to detecting erythrocyte, leukocyte, platelet and detection biochemical indicator, evaluate anti-radiotherapy, chemotherapy degree, promptly carry out the number of times of radiotherapy, chemotherapy continuously;
Weigh the effect of Chinese medicine preparation of the present invention with above-mentioned two indexs;
(2) clinical practice result:
Testing result shows:
The treatment group:
Use Chinese medicine preparation tumor cure rate average 95%～98% of the present invention, anti-radiotherapy, chemotherapy degree: seriality radiation and chemotherapy number of times reaches 12 times (to carry out 12 months or longer continuously by a radiotherapy in every month, chemotherapy, simultaneously every day 3 times, each 30g takes Chinese medicine preparation of the present invention); Follow up a case by regular visits to and surplusly do not see recurrence in 5 years;
Continuous 12 radiotherapies of individual patient, chemotherapy, simultaneously every day 3 times, each 30g takes Chinese medicine preparation of the present invention, and tumor is promptly eliminated; Follow up a case by regular visits to and do not see recurrence in 5 years;
Matched group 1:
Do not use Chinese medicine preparation person tumor cure rate average 2%～5% of the present invention; Anti-radiotherapy, chemotherapy degree: average 2 times of seriality radiation and chemotherapy number of times; Relapse rate is more than 90% after 1 year;
Matched group 2:
Do not use Chinese medicine preparation person tumor cure rate of the present invention average 2～5%, anti-radiotherapy, chemotherapy degree: seriality radiation and chemotherapy number of times 3～5 times; Relapse rate is more than 90% after 1 year.
The tumor cure rate of more above-mentioned treatment group and each matched group, anti-radiotherapy, chemotherapy degree are as can be seen, the effect that Chinese medicine preparation of the present invention and radiotherapy, chemotherapy are used is fairly obvious, improved the level of the toxic and side effects of resisting the radiation and chemotherapy generation, operation back cancer patient can accept radiation and chemotherapy continuously, and the reduction relapse rate, anti-radiotherapy, chemotherapy degree (promptly carrying out the number of times of radiotherapy, chemotherapy continuously) exceed matched group far away.Cure or prolong patient's life for tumor possibility is provided.Solved at present because of using radiotherapy, toxic and side effects that chemotherapy produced merely, and can not carry out radiotherapy, chemotherapy continuously, had to be forced to the difficult point that the Halfway Stopping continuous effective is implemented chemicotherapy.Be used Chinese medicine preparation of the present invention, changed and improved the cure rate that malignant tumor is cured in radiotherapy, chemotherapy greatly, changed deficiency and present situation that radiotherapy, chemotherapy one leg are walked.
Claims (4)
1, the Chinese medicine preparation that is used of a kind of and radiotherapy, chemotherapy is characterized in that it is by following 30 kinds of compound recipes that the graininess concentrated traditional Chinese medicine is formed, and each graininess concentrated traditional Chinese medicine consumption is as follows by weight:
Radix Angelicae Sinensis 20～30, Radix Pseudostellariae 20～30, Radix Rehmanniae Preparata 20～30,
Fructus Corni 20～30, Poria 20～30 is given birth to Semen Coicis 20～30,
Endothelium Corneum Gigeriae Galli 20～30, Rhizoma Cyperi 20～30, Rhizoma Alismatis 20～30,
Cortex Moutan 20～30, Radix Asparagi 20～30, Radix Ophiopogonis 20～30,
Rhizoma Paridis 20～30, Colla Corii Asini 20～30, Cordyceps 20～30,
Pericarpium Citri Reticulatae Viride 20～30, Caulis Bambusae In Taenia 20～30, Radix Morindae Officinalis 20～30,
RHIIZOMA DIOSCOREAE frOm Henan of China 20～30, Radix Curcumae 20～30, Radix Bupleuri 20～30,
Caulis Spatholobi 20～30, Radix Adenophorae (Radix Glehniae) 20～30, Radix Ginseng Rubra 20～30,
Fructus Aurantii 20～30, SHANZHIZI 20～30, Rhizoma Curcumae 20～30,
Fructus Schisandrae Chinensis 5～10, Stigma Croci 5～10, Pericarpium Citri Reticulatae 5～10;
Described each graininess concentrated traditional Chinese medicine cocnentration factor by weight is identical.
2, Chinese medicine preparation according to claim 1 is characterized in that, described graininess concentrated traditional Chinese medicine cocnentration factor by weight is: the ratio of the graininess concentrated traditional Chinese medicine weight that raw materials used weight and raw material with this weight obtain; Described raw material is meant the raw material of Chinese medicine medicine or the prepared slices of Chinese crude drugs.
3, Chinese medicine preparation according to claim 1 and 2 is characterized in that, described graininess concentrated traditional Chinese medicine cocnentration factor by weight is 5:1.
4, Chinese medicine preparation according to claim 1 is characterized in that, its dosage form is an oral granule type Chinese medicine preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008102425956A CN101450198A (en) | 2008-12-30 | 2008-12-30 | Traditional Chinese medicine preparation mated with radiotherapy and chemotherapy |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2008102425956A CN101450198A (en) | 2008-12-30 | 2008-12-30 | Traditional Chinese medicine preparation mated with radiotherapy and chemotherapy |
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| CN101450198A true CN101450198A (en) | 2009-06-10 |
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| CNA2008102425956A Pending CN101450198A (en) | 2008-12-30 | 2008-12-30 | Traditional Chinese medicine preparation mated with radiotherapy and chemotherapy |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103142891A (en) * | 2013-04-02 | 2013-06-12 | 石欣 | Medicine for preventing and treating adverse reactions after radiotherapy on head and neck tumors |
| CN104825863A (en) * | 2015-04-27 | 2015-08-12 | 陶俊荣 | Health-care medicated diet for relieving side effects of radiotherapy and preparation method thereof |
| CN105687696A (en) * | 2016-02-02 | 2016-06-22 | 南方医科大学南方医院 | Traditional Chinese medicine composition for increasing ovarian cancer chemotherapy sensibility and application thereof |
-
2008
- 2008-12-30 CN CNA2008102425956A patent/CN101450198A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103142891A (en) * | 2013-04-02 | 2013-06-12 | 石欣 | Medicine for preventing and treating adverse reactions after radiotherapy on head and neck tumors |
| CN104825863A (en) * | 2015-04-27 | 2015-08-12 | 陶俊荣 | Health-care medicated diet for relieving side effects of radiotherapy and preparation method thereof |
| CN105687696A (en) * | 2016-02-02 | 2016-06-22 | 南方医科大学南方医院 | Traditional Chinese medicine composition for increasing ovarian cancer chemotherapy sensibility and application thereof |
| CN105687696B (en) * | 2016-02-02 | 2019-08-30 | 南方医科大学南方医院 | Improve Chinese medicine composition and its application of chemotherapy in ovarian cancer sensibility |
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Open date: 20090610 |