CN105687307A - Composition containing kudzuvine roots and preparation method of composition - Google Patents
Composition containing kudzuvine roots and preparation method of composition Download PDFInfo
- Publication number
- CN105687307A CN105687307A CN201610136556.2A CN201610136556A CN105687307A CN 105687307 A CN105687307 A CN 105687307A CN 201610136556 A CN201610136556 A CN 201610136556A CN 105687307 A CN105687307 A CN 105687307A
- Authority
- CN
- China
- Prior art keywords
- radix puerariae
- extract
- tea
- compositions containing
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 54
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 244000046146 Pueraria lobata Species 0.000 title abstract 6
- 235000010575 Pueraria lobata Nutrition 0.000 title abstract 6
- 239000000284 extract Substances 0.000 claims abstract description 48
- 239000001508 potassium citrate Substances 0.000 claims abstract description 27
- 229960002635 potassium citrate Drugs 0.000 claims abstract description 27
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 claims abstract description 27
- 235000011082 potassium citrates Nutrition 0.000 claims abstract description 27
- 239000001509 sodium citrate Substances 0.000 claims abstract description 25
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims abstract description 25
- 235000019224 Camellia sinensis var Qingmao Nutrition 0.000 claims abstract description 23
- 235000020339 pu-erh tea Nutrition 0.000 claims abstract description 23
- 239000000843 powder Substances 0.000 claims abstract description 20
- 235000013616 tea Nutrition 0.000 claims abstract description 20
- 150000008442 polyphenolic compounds Chemical class 0.000 claims abstract description 17
- 235000013824 polyphenols Nutrition 0.000 claims abstract description 17
- 239000011343 solid material Substances 0.000 claims abstract description 11
- 241001122767 Theaceae Species 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 238000002156 mixing Methods 0.000 claims description 10
- 238000010298 pulverizing process Methods 0.000 claims description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 9
- 239000000469 ethanolic extract Substances 0.000 claims description 7
- 238000009835 boiling Methods 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 238000003809 water extraction Methods 0.000 claims description 6
- 238000000605 extraction Methods 0.000 claims description 3
- 238000000874 microwave-assisted extraction Methods 0.000 claims description 3
- 238000004806 packaging method and process Methods 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 abstract description 29
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 abstract description 29
- 229940116269 uric acid Drugs 0.000 abstract description 29
- 239000008280 blood Substances 0.000 abstract description 9
- 210000004369 blood Anatomy 0.000 abstract description 9
- 230000036772 blood pressure Effects 0.000 abstract description 5
- 230000006870 function Effects 0.000 abstract description 2
- 244000269722 Thea sinensis Species 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 13
- 230000000694 effects Effects 0.000 description 12
- 239000002994 raw material Substances 0.000 description 8
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 4
- 239000004925 Acrylic resin Substances 0.000 description 4
- 229920000178 Acrylic resin Polymers 0.000 description 4
- RXUWDKBZZLIASQ-UHFFFAOYSA-N Puerarin Natural products OCC1OC(Oc2c(O)cc(O)c3C(=O)C(=COc23)c4ccc(O)cc4)C(O)C(O)C1O RXUWDKBZZLIASQ-UHFFFAOYSA-N 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- HKEAFJYKMMKDOR-VPRICQMDSA-N puerarin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1C1=C(O)C=CC(C2=O)=C1OC=C2C1=CC=C(O)C=C1 HKEAFJYKMMKDOR-VPRICQMDSA-N 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000029142 excretion Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- 208000001647 Renal Insufficiency Diseases 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- OFCNXPDARWKPPY-UHFFFAOYSA-N allopurinol Chemical group OC1=NC=NC2=C1C=NN2 OFCNXPDARWKPPY-UHFFFAOYSA-N 0.000 description 2
- 229960003459 allopurinol Drugs 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 230000002354 daily effect Effects 0.000 description 2
- 208000017169 kidney disease Diseases 0.000 description 2
- 201000006370 kidney failure Diseases 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000004089 microcirculation Effects 0.000 description 2
- 201000008383 nephritis Diseases 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 201000006474 Brain Ischemia Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 206010008120 Cerebral ischaemia Diseases 0.000 description 1
- 208000002682 Hyperkalemia Diseases 0.000 description 1
- 201000001431 Hyperuricemia Diseases 0.000 description 1
- 208000019025 Hypokalemia Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 229940087098 Oxidase inhibitor Drugs 0.000 description 1
- 241000219780 Pueraria Species 0.000 description 1
- 206010063837 Reperfusion injury Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229960002529 benzbromarone Drugs 0.000 description 1
- WHQCHUCQKNIQEC-UHFFFAOYSA-N benzbromarone Chemical compound CCC=1OC2=CC=CC=C2C=1C(=O)C1=CC(Br)=C(O)C(Br)=C1 WHQCHUCQKNIQEC-UHFFFAOYSA-N 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000016097 disease of metabolism Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 235000021590 normal diet Nutrition 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 208000024896 potassium deficiency disease Diseases 0.000 description 1
- 239000000955 prescription drug Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 229960003081 probenecid Drugs 0.000 description 1
- DBABZHXKTCFAPX-UHFFFAOYSA-N probenecid Chemical compound CCCN(CCC)S(=O)(=O)C1=CC=C(C(O)=O)C=C1 DBABZHXKTCFAPX-UHFFFAOYSA-N 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 229960003329 sulfinpyrazone Drugs 0.000 description 1
- MBGGBVCUIVRRBF-UHFFFAOYSA-N sulfinpyrazone Chemical compound O=C1N(C=2C=CC=CC=2)N(C=2C=CC=CC=2)C(=O)C1CCS(=O)C1=CC=CC=C1 MBGGBVCUIVRRBF-UHFFFAOYSA-N 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- 230000003424 uricosuric effect Effects 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses composition containing kudzuvine roots. The composition comprises components in parts by weight as follows: 1-30 parts of kudzuvine roots, 4.5-4.8 parts of potassium citrate and 3.8-4.1 parts of sodium citrate. According to a preparation method, a kudzuvine root extract and a Pu'er tea extract are prepared, potassium citrate, sodium citrate, the kudzuvine root extract, tea polyphenol, the Pu'er tea extract and matcha powder are uniformly mixed and subjected to ultramicro crushing, the granularity of solid materials is smaller than or equal to 0.5 mu m, and the composition containing the kudzuvine roots is prepared. The composition has the functions of reducing uric acid, reducing blood pressure, reducing blood sugar and the like.
Description
Technical field
The present invention relates to a kind of compositions with special efficacy, particularly relate to a kind of composition and method of making the same containing Radix Puerariae。
Background technology
Uric acid height is to have a kind of material being called purine to get muddled because of metabolism in human body, a kind of metabolic disease causing uric acid in blood to increase and to cause, growing amount and the excretion of internal uric acid every day are about equal, growing amount aspect, 1/3rd is by food, 2/3rds is internal synthesize voluntarily, and excretion pathway is then 1/3rd discharged by intestinal, and 2/3rds from renal excretion。As long as above-mentioned various approach has any one to go wrong, will result in uric acid and raise。Uric acid rises, because it can hinder the process of blood secretion uric acid, makes uric acid to discharge。Uric acid is too high, also can cause other diseases。The medicine treating metabolic arthritis disease at present includes: releasing uric acid prescription drugs: uricosuric mainly includes probenecid, sulfinpyrazone, benzbromarone etc.。Such medicine can stop the renal tubules heavily absorption to uric acid, increase the discharge of uric acid, thus playing the effect reducing blood in human body in uric acid level, also other trace element of human body is also excreted the while that how uricotelic side effect is, low blood sodium, hypokalemia, low blood calcium can be caused, so use can not be grown, but also liver, kidney there are is side effect, more can not grow use。Suppress the medicine of uricopoiesis: within 2013, the medicine suppressing uricopoiesis conventional clinically is allopurinol。This medicine is the purine oxidase inhibitor of a kind of brute force, and it is also only up to now can effectively reduce uricopoiesis, reduce the medicine of uric acid level in human body。Although the untoward reaction of allopurinol is less, but hepatic and kidney function obstacle person also should be cautious use of。
The medicine of alkalized urine: alkalescent medicine this nothing uric acid resisting effects such as sodium bicarbonate but can alkalized urine, increase uric acid dissolubility in blood, make uric acid not easily gather in urine and form crystallization。
Radix Puerariae, sweet in the mouth, pungent, property is put down, and returns spleen, stomach, lung, bladder warp。Expelling pathogenic factors from muscles for reducing heat；Deliver and examine；Promoting the production of body fluid to quench thirst；Yang invigorating antidiarrheal。Puerarin (Puerarin) is to extract to separate the active component obtained from the dry root of Herba Gelsemii Elegantis (PuerariaLabata); there is the effects such as antioxidation, blood pressure lowering, blood sugar lowering, anti-cerebral ischemia reperfusion injury; puerarin can be expanded blood vessel, reduces blood pressure, improve microcirculation, and nephritis, nephropathy renal failure model are all had protective effect。
Summary of the invention
It is an object of the invention to provide a kind of composition and method of making the same containing Radix Puerariae extract, powder of Radix Puerariae, Radix Puerariae extract, potassium citrate, sodium citrate, tea polyphenols, Pu'er tea, matcha powder are combined, it is provided that there is the functional composition reducing the effects such as uric acid, blood pressure lowering, blood sugar lowering。
It is an object of the invention to be achieved through the following technical solutions:
A kind of compositions containing Radix Puerariae of the present invention, forms by weight including following component: Radix Puerariae 1～30 part, potassium citrate 4.5-4.8 part, sodium citrate 3.8～4.1 parts。
Further, the described compositions containing Radix Puerariae also includes tea polyphenols 0.1～0.3 part, Pu'er tea 0.3～0.5 part, matcha powder 1～3 part；
Further, the described compositions containing Radix Puerariae extract also includes acrylic resin 0.1～0.3 part。
Further, the described compositions containing Radix Puerariae includes following component and forms by weight: potassium citrate 4.63 parts, sodium citrate 3.9 parts, Radix Puerariae extract 2 parts, tea polyphenols 0.2 part, Pu'er tea 0.4 part, matcha powder 2 parts。
The preparation method of a kind of compositions containing Radix Puerariae extract, it is characterised in that comprise the following steps:
(1) preparation of Radix Puerariae extract:
By Radix Puerariae by the ethanol microwave extraction 2 times of the 75% of 5 times amount, retain Radix Puerariae medicinal residues, extracting solution filtering and concentrating, prepare Radix Puerariae ethanol extract；
By the water boiling water extraction 2 times of 8 times amount of the Radix Puerariae medicinal residues after alcohol extraction, abandon or adopt medicinal residues, extracting solution filtering and concentrating, prepare Radix Puerariae water extract；
Radix Puerariae ethanol extract and water extract are mixed, obtains Radix Puerariae extract；
(2) preparation of Pu'er tea:
By the Folium camelliae assamicae water boiling water extraction 2 times of 8 times amount, abandoning or adopting tea grounds, extracting solution is concentrated into dry, prepares Pu'er tea；
(3) by potassium citrate, sodium citrate, Radix Puerariae extract, tea polyphenols, Pu'er tea, matcha powder mixing, micronized pulverization, make granularity≤0.5 μm of solid material, prepare the compositions containing Radix Puerariae extract。
Further, in described step (1), Radix Puerariae ethanol extract and water extract are mixed, joins in acrylic resin, stir, obtain Radix Puerariae extract。
Further, the compositions containing Radix Puerariae extract prepared according to the needs of preparation and packaging, can make various pharmaceutical formulation。
Inventor is in R&D process, by potassium citrate 4.5-4.8 part, sodium citrate 3.8～4.1 parts, tea polyphenols 0.1～0.3 part, Pu'er tea 0.3～0.5 part, 1～3 part of prepared compositions of matcha powder also has also has good effect to reduction uric acid, the effect reducing uric acid is better than potassium citrate 4.5-4.8 part, the compositions of sodium citrate 3.8～4.1 parts composition, reduce the effect of uric acid lower than in potassium citrate 4.5-4.8 part, sodium citrate 3.8～4.1 parts, Radix Puerariae extract 0.2 part, tea polyphenols 0.1～0.3 part, Pu'er tea 0.3～0.5 part, the compositions of matcha powder 1～3 part composition。
Advantages of the present invention:
1., in the compositions containing Radix Puerariae extract of the present invention, use potassium citrate and sodium citrate can significantly reduce uric acid content；Add Radix Puerariae and Radix Puerariae extract; blood vessel can be expanded, reduce blood pressure, improve microcirculation; nephritis, nephropathy renal failure model all there is protective effect; effect of uric acid content is reduced in enhancing composition; that can reduce potassium citrate and sodium citrate makes consumption simultaneously, it is prevented that cause the risk of hyperpotassemia when using this compositions；
2. addition Pu'er tea and matcha powder not only improve the mouthfeel of compositions, it is also possible to increase the health-care effect of compositions；Tea polyphenols can increase the antioxidant capacity of compositions, the preservation being beneficial in compositions puerarin。
3. compositions is added acrylic resin, it is possible to make the Radix Puerariae in compositions have good slow releasing function, extend the onset time that compositions uses。
Detailed description of the invention
Below in conjunction with specific embodiment, the invention will be further described:
The preparation of Radix Puerariae extract:
By Radix Puerariae by the ethanol microwave extraction 2 times of the 75% of 5 times amount, retaining Radix Puerariae medicinal residues, extracting solution filtering and concentrating, to dry, prepares Radix Puerariae ethanol extract；By the water boiling water extraction 2 times of 8 times amount of the Radix Puerariae medicinal residues after alcohol extraction, abandoning or adopting medicinal residues, extracting solution filtering and concentrating, to dry, prepares Radix Puerariae water extract；
Radix Puerariae ethanol extract and water extract are mixed, adds water and adjust to weight is raw pueraria medical material amount 10%, obtain Radix Puerariae extract；
The preparation of Pu'er tea:
By the Folium camelliae assamicae water boiling water extraction 2 times of 8 times amount, abandoning or adopting tea grounds, extracting solution is concentrated into dry, prepares Pu'er tea；
Embodiment 1
Weigh powder of Radix Puerariae 1 gram, potassium citrate 4.63 grams, sodium citrate 3.9 grams by weight；
The raw material blending that will weigh, micronized pulverization, make granularity≤0.5 μm of solid material, prepare the compositions containing Radix Puerariae extract。
Embodiment 2
Weigh powder of Radix Puerariae 10 grams, potassium citrate 4.63 grams, sodium citrate 3.9 grams by weight；
The raw material blending that will weigh, micronized pulverization, make granularity≤0.5 μm of solid material, prepare the compositions containing Radix Puerariae extract。
Embodiment 3
Weigh powder of Radix Puerariae 30 grams, potassium citrate 4.63 grams, sodium citrate 3.9 grams by weight；
The raw material blending that will weigh, micronized pulverization, make granularity≤0.5 μm of solid material, prepare the compositions containing Radix Puerariae extract。
Embodiment 4
Weigh potassium citrate 4.5 grams, sodium citrate 4.1 grams, Radix Puerariae extract 0.1 gram, tea polyphenols 0.3 gram, Pu'er tea 0.3 gram, matcha powder 1 gram by weight；
The raw material blending that will weigh, micronized pulverization, make granularity≤0.5 μm of solid material, prepare the compositions containing Radix Puerariae extract。
Embodiment 5
Weigh potassium citrate 4.63 grams, sodium citrate 3.9 grams, Radix Puerariae extract 1 gram, tea polyphenols 0.2 gram, Pu'er tea 0.4 gram, matcha powder 2 grams by weight；
The raw material blending that will weigh, micronized pulverization, make granularity≤0.5 μm of solid material, prepare the compositions containing Radix Puerariae extract。
Embodiment 6
Weigh potassium citrate 4.8 grams, sodium citrate 3.8 grams, Radix Puerariae extract 3 grams, tea polyphenols 0.1 gram, Pu'er tea 0.5 gram, matcha powder 3 grams by weight；
The raw material blending that will weigh, micronized pulverization, make granularity≤0.5 μm of solid material, prepare the compositions containing Radix Puerariae extract。
Embodiment 7
Weigh potassium citrate 4.63 grams, sodium citrate 3.9 grams, Radix Puerariae extract 1 gram, tea polyphenols 0.2 gram, Pu'er tea 0.4 gram, matcha powder 2 grams, acrylic resin 0.2 gram by weight；
Embodiment 8
Weigh Radix Puerariae 20 grams, potassium citrate 4.63 grams, sodium citrate 3.9 grams, Radix Puerariae extract 2 grams, tea polyphenols 0.2 gram, Pu'er tea 0.4 gram, matcha powder 2 grams by weight；
Embodiment 9
Weigh tea polyphenols 0.2 gram, potassium citrate 4.63 grams, sodium citrate 3.9 grams by weight；
The raw material blending that will weigh, micronized pulverization, make granularity≤0.5 μm of solid material, prepare the compositions containing Radix Puerariae extract。
Embodiment 10
Weigh starch 30 grams, potassium citrate 4.63 grams, sodium citrate 3.9 grams by weight；
The raw material blending that will weigh, micronized pulverization, make granularity≤0.5 μm of solid material, prepare the compositions containing Radix Puerariae extract。
Contrast experiment:
Choose volunteer Zhang 65 years old male, Wang 68 years old women, Lee 62 years old women, Tang 70 years old male, what certain 66 years old male, Zhao 64 women, 55 years old male of the Qin of six hyperuricemia diseases, measure uric acid content respectively, the daily compositions of embodiment 2 preparation, by potassium citrate amount 0.01 gram/day, take 10, within every 3 days, survey uric acid once；Drug withdrawal after 10 days, treats that the uric acid level of volunteer can rise to the level before not taking medicine, daily the compositions of embodiment 6 preparation, by potassium citrate amount 0.01 gram/day, take 10, within every 3 days, survey uric acid once, first time measurement result is the measured value of thing of not taking medicine, record contrast and experiment；Normal diet is all kept during taking medicine。
Uric acid detection log:
From upper table result, add the compositions after Radix Puerariae or Radix Puerariae extract, compositions relative to potassium citrate and sodium citrate, the effect reducing uric acid content is remarkably reinforced, in contrast experiment, by the tracking of taking medicine to the volunteer that takes medicine, taking the compositions after adding Radix Puerariae or Radix Puerariae extract, pain substantially slows down。
Claims (5)
1. the compositions containing Radix Puerariae, it is characterised in that include following component and form by weight: Radix Puerariae 1～30 part, potassium citrate 4.5-4.8 part, sodium citrate 3.8～4.1 parts。
2. the compositions containing Radix Puerariae according to claim 1, it is characterised in that the described compositions containing Radix Puerariae also includes tea polyphenols 0.1～0.3 part, Pu'er tea 0.3～0.5 part, matcha powder 1～3 part。
3. the compositions containing Radix Puerariae extract according to claim 2, it is characterized in that, form by weight including following component: potassium citrate 4.63 parts, sodium citrate 3.9 parts, Radix Puerariae 40 parts, tea polyphenols 0.2 part, Pu'er tea 0.4 part, matcha powder 2 parts。
4. the preparation method of the compositions containing Radix Puerariae, it is characterised in that comprise the following steps:
(1) preparation of Radix Puerariae extract:
By Radix Puerariae by the ethanol microwave extraction 2 times of the 75% of 5 times amount, retain Radix Puerariae medicinal residues, extracting solution filtering and concentrating, prepare Radix Puerariae ethanol extract；
By the water boiling water extraction 2 times of 8 times amount of the Radix Puerariae medicinal residues after alcohol extraction, abandon or adopt medicinal residues, extracting solution filtering and concentrating, prepare Radix Puerariae water extract；
Radix Puerariae ethanol extract and water extract are mixed, obtains Radix Puerariae extract；
(2) preparation of Pu'er tea:
By the Folium camelliae assamicae water boiling water extraction 2 times of 8 times amount, abandoning or adopting tea grounds, extracting solution is concentrated into dry, prepares Pu'er tea；
(3) by potassium citrate, sodium citrate, Radix Puerariae extract, tea polyphenols, Pu'er tea, matcha powder mixing, micronized pulverization, make granularity≤0.5 μm of solid material, prepare the compositions containing Radix Puerariae extract。
5. the preparation method of the compositions containing Radix Puerariae according to claim 4, it is characterised in that in described step (3), the compositions containing Radix Puerariae extract prepared according to the needs of preparation and packaging, can make various pharmaceutical formulation。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610136556.2A CN105687307A (en) | 2016-03-10 | 2016-03-10 | Composition containing kudzuvine roots and preparation method of composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610136556.2A CN105687307A (en) | 2016-03-10 | 2016-03-10 | Composition containing kudzuvine roots and preparation method of composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105687307A true CN105687307A (en) | 2016-06-22 |
Family
ID=56221380
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610136556.2A Pending CN105687307A (en) | 2016-03-10 | 2016-03-10 | Composition containing kudzuvine roots and preparation method of composition |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105687307A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108531341A (en) * | 2018-07-17 | 2018-09-14 | 劲牌有限公司 | A kind of health-care spirit and preparation method thereof for having effects that auxiliary and alleviating gout |
| CN109007472A (en) * | 2018-07-25 | 2018-12-18 | 黔西南州贵隆农业发展有限公司 | A kind of kudzuvine-root health-care beverage and preparation method thereof |
| CN111419894A (en) * | 2020-05-29 | 2020-07-17 | 鲁雪梅 | Pharmaceutical composition for reducing uric acid and preparation method thereof |
| CN111529575A (en) * | 2020-05-29 | 2020-08-14 | 鲁雪梅 | A pharmaceutical composition for treating gout and/or hyperuricemia, and its preparation method |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1602926A (en) * | 2004-08-09 | 2005-04-06 | 汪卫东 | Kudzuvine root containing capsule capable of regulating blood pressure and blood fat, preventing and treating cardiovascular and cerebrovascular diseases |
| CN101744199A (en) * | 2009-12-25 | 2010-06-23 | 重庆正里元实业有限公司 | Instant nutrient pueraria cream and preparation technology |
| CN101805410A (en) * | 2010-03-29 | 2010-08-18 | 武汉俩发科技有限公司 | Technological method for comprehensively producing pueraria flavonid, puerarin and arrowroot starch |
-
2016
- 2016-03-10 CN CN201610136556.2A patent/CN105687307A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1602926A (en) * | 2004-08-09 | 2005-04-06 | 汪卫东 | Kudzuvine root containing capsule capable of regulating blood pressure and blood fat, preventing and treating cardiovascular and cerebrovascular diseases |
| CN101744199A (en) * | 2009-12-25 | 2010-06-23 | 重庆正里元实业有限公司 | Instant nutrient pueraria cream and preparation technology |
| CN101805410A (en) * | 2010-03-29 | 2010-08-18 | 武汉俩发科技有限公司 | Technological method for comprehensively producing pueraria flavonid, puerarin and arrowroot starch |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108531341A (en) * | 2018-07-17 | 2018-09-14 | 劲牌有限公司 | A kind of health-care spirit and preparation method thereof for having effects that auxiliary and alleviating gout |
| CN109007472A (en) * | 2018-07-25 | 2018-12-18 | 黔西南州贵隆农业发展有限公司 | A kind of kudzuvine-root health-care beverage and preparation method thereof |
| CN111419894A (en) * | 2020-05-29 | 2020-07-17 | 鲁雪梅 | Pharmaceutical composition for reducing uric acid and preparation method thereof |
| CN111529575A (en) * | 2020-05-29 | 2020-08-14 | 鲁雪梅 | A pharmaceutical composition for treating gout and/or hyperuricemia, and its preparation method |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105687307A (en) | Composition containing kudzuvine roots and preparation method of composition | |
| CN103349323A (en) | Radix puerariae anti-alcoholism beverage recipe | |
| CN101822749A (en) | Medicinal preparation for curing hypertension and hyperlipaemia and preparation method thereof | |
| CN105265985B (en) | A kind of corn stigma solid beverage and preparation method thereof | |
| CN107596241A (en) | A kind of anti-alcohol and liver-protection traditional Chinese medicine composition and its production and use | |
| CN105769970A (en) | Siraitia grosvenorii chewable tablets and preparation method thereof | |
| CN103300367A (en) | Health care drink with lipid-decreasing function and preparation method thereof | |
| CN109045273A (en) | A kind of Chinese medicinal alcoholism-relieving composition and preparation method thereof | |
| CN105380041A (en) | Preparation technique for kiwi fruit dogwood Lycium chinensis health-care beverage | |
| CN103705768B (en) | The compositions of prevention alcoholic liver disease and application thereof | |
| CN105410580B (en) | A kind of corn stigma effervescent solid beverage and preparation method thereof | |
| CN104824779A (en) | Theabrownin health-caring solid beverage | |
| CN115137068A (en) | Composition for reducing uric acid and application thereof | |
| CN104055115B (en) | A kind of health products containing agate coffee, the stem of noble dendrobium and Panax Japonicus Var. Major and preparation method thereof | |
| CN100396189C (en) | Fruit food for nourishing liver and reducing fat and its producing method | |
| CN113384612A (en) | Anti-gout composition and preparation method and application thereof | |
| CN113876896A (en) | Three-rice-drink traditional Chinese medicine formula composition for reducing uric acid and relieving gout and preparation process thereof | |
| CN102599312B (en) | Oligosaccharide Panax notoginseng sweet tea and preparation method thereof | |
| CN102188642A (en) | Weight-losing and body-building health-care wine and preparation method thereof | |
| CN104474337A (en) | Preparation method of Chinese patent health granule containing green tea extract | |
| CN114191499B (en) | Traditional Chinese medicine composition for relieving liver and kidney injury | |
| CN108671055A (en) | A kind of Chinese medicine composition of spleen tonifying and fat and preparation method thereof | |
| CN106728718A (en) | A kind of Chinese medicine for treating hyperuricemia | |
| CN101164595A (en) | Traditional Chinese medicine for curing anorexia | |
| CN104940446A (en) | Anti-fatigue foot bath powder and method for producing the same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160622 |