CN105685022A - Paraben composition water dispersion system and preparation method thereof - Google Patents
Paraben composition water dispersion system and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a paraben composition water dispersion system and a preparation method thereof. The preparation method comprises the following steps: providing a paraben composition organic solvent dispersion system, wherein the composition organic solvent dispersion system comprises a paraben substance, an organic solvent and at least one of an ampholytic surfactant and a nonionic surfactant, and the organic solvent and water are mixed according to an arbitrary ratio; and adding the paraben composition organic solvent dispersion system to water while stirring to form the uniformly and stably dispersed paraben composition water dispersion system. The method adopting the above mode has the advantages of uniform and stable dispersion of the paraben substance in water, simple operation, time saving and energy saving.
Description
Technical field
The present invention relates to dispersion technical field, particularly relate to a kind of Nipagin ester compositions aqueous dispersion and preparation method。
Background technology
Parabens material is neutral preservative, stable chemical nature, and high temperature resistant, and not easy oxidation discoloration is easy to use；It addition, parabens material good antimicrobial effect, and low toxicity, safety height, there is the advantage such as wide spectrum, easy compatibility。Therefore, parabens material, as preservative, is widely used in the fields such as medicine, food, medicated beer, beverage, Nicotiana tabacum L., feedstuff, cosmetics, cleaning agent, weaving, papermaking, coating。
The water solublity of parabens material is relatively low, poor dispersion in water。In prior art, the solubilization method of parabens material mainly has two kinds: first, adopts the mode of heating to make parabens material dissolve；Second, adopt the alcohols solubilising such as ethanol, propylene glycol。
But, in said method, first method complex operation, length consuming time and energy consumption are high；Second method is in reality allotment uses, and when alcohols makes usage ratio higher, parabens material is still easily with Precipitation, and its water solublity and dispersibility are still not good。
Summary of the invention
The technical problem that present invention mainly solves is to provide Nipagin ester compositions aqueous dispersion and preparation method, it is possible to make parabens material be uniformly dispersed in water and stable, and simple to operate, save time, energy-conservation。
For solving above-mentioned technical problem, the technical scheme that the present invention adopts is: provide a kind of Nipagin ester compositions aqueous dispersion, compositions aqueous dispersion includes: at least one in parabens material, organic solvent, amphoteric surfactant and nonionic surfactant and water, wherein, organic solvent and water can be miscible with arbitrary proportion, and the parabens material in compositions aqueous dispersion is uniformly dispersed and stable in water。
Wherein, organic solvent is alcohol organic solvent。
Wherein, the weight/mass percentage composition of parabens material is 0.01%～1%。
Wherein, the weight/mass percentage composition of alcohol organic solvent is 0.04%～15%。
Wherein, the weight/mass percentage composition of amphoteric surfactant is 0.01%～1%。
Wherein, the weight/mass percentage composition of nonionic surfactant is 0.04%～10%。
Wherein, parabens includes at least one in methyl hydroxybenzoate, ethyl hydroxybenzoate, propylparaben, butoben, iso-butyl p-hy-droxybenzoate。
Wherein, alcohol organic solvent includes at least one in propylene glycol, ethohexadiol, 1,3 butylene glycol, pentanediol, phenoxyethanol, hexanediol。
Wherein, amphoteric surfactant includes at least one of betanin derivative, both sexes Acetates, propionate compound, sulfosuccinate apoplexy due to endogenous wind。
Wherein, amphoteric surfactant is betanin derivative, both sexes Acetates or its mixture。
Wherein, betanin derivative includes cocamido propyl betaine, lauroyl CAB, octyl group/decylamidopropyl glycine betaine, ricinoleic acid amide CAB, dodecyl ethyoxyl sulfobetaines, dodecyl hydroxypropyl sulfobetaines, dodecyl sulfobetaine；Both sexes Acetates includes cocos nucifera oil both sexes sodium acetate, cocos nucifera oil both sexes diacetic acid disodium, Semen pruni armeniacae oil both sexes sodium acetate, cocoa butter both sexes sodium acetate；Propionate compound includes cocos nucifera oil both sexes sodium propionate；2-Sulfosuccinic acid salt includes Polyethylene Glycol-5 lauryl citric acid disodium sulfosuccinate, lauryl alcohol disodium sulfosuccinate, ricinoleic acid amide monoethanolamine disodium sulfosuccinate, lauryl disodium sulfosuccinate。
Wherein, nonionic surfactant includes at least one in TWEEN Series, castor oil hydrogenated。
Wherein, TWEEN Series includes tween 20, Tween-60, tween 80；Described castor oil hydrogenated includes Cremophor RH40, PEG-60 castor oil hydrogenated。
For solving above-mentioned technical problem, another technical solution used in the present invention is: the preparation method providing a kind of Nipagin ester based composition aqueous dispersion, including: Nipagin ester based composition organic solvent dispersion system is provided, compositions organic solvent dispersion system includes: parabens material, organic solvent and amphoteric surfactant and at least one in nonionic surfactant, wherein, organic solvent and water can be miscible with arbitrary proportion；Nipagin ester based composition organic solvent dispersion system is under agitation added to the water, is formed and be uniformly dispersed and stable Nipagin ester based composition aqueous dispersion。
Wherein, organic solvent is alcohol organic solvent。
Wherein, the weight/mass percentage composition of parabens material is 0.01%～1%。
Wherein, the weight/mass percentage composition of alcohol organic solvent is 0.04%～15%。
Wherein, the weight/mass percentage composition of amphoteric surfactant is 0.01%～1%。
Wherein, the weight/mass percentage composition of nonionic surfactant is 0.04%～10%。
Wherein, parabens includes at least one in methyl hydroxybenzoate, ethyl hydroxybenzoate, propylparaben, butoben, iso-butyl p-hy-droxybenzoate。
Wherein, alcohol organic solvent includes at least one in propylene glycol, ethohexadiol, 1,3 butylene glycol, pentanediol, phenoxyethanol, hexanediol。
Wherein, amphoteric surfactant includes at least one of betanin derivative, both sexes Acetates, propionate compound, sulfosuccinate apoplexy due to endogenous wind。
Wherein, it is characterised in that amphoteric surfactant is betanin derivative, both sexes Acetates or its mixture。
Wherein, betanin derivative includes cocamido propyl betaine, lauroyl CAB, octyl group/decylamidopropyl glycine betaine, ricinoleic acid amide CAB, dodecyl ethyoxyl sulfobetaines, dodecyl hydroxypropyl sulfobetaines, dodecyl sulfobetaine；Both sexes Acetates includes cocos nucifera oil both sexes sodium acetate, cocos nucifera oil both sexes diacetic acid disodium, Semen pruni armeniacae oil both sexes sodium acetate, cocoa butter both sexes sodium acetate；Propionate compound includes cocos nucifera oil both sexes sodium propionate；2-Sulfosuccinic acid salt includes Polyethylene Glycol-5 lauryl citric acid disodium sulfosuccinate, lauryl alcohol disodium sulfosuccinate, ricinoleic acid amide monoethanolamine disodium sulfosuccinate, lauryl disodium sulfosuccinate。
Wherein, nonionic surfactant includes at least one in TWEEN Series, castor oil hydrogenated。
Wherein, TWEEN Series includes tween 20, Tween-60, tween 80；Castor oil hydrogenated includes Cremophor RH40, PEG-60 castor oil hydrogenated。
The invention has the beneficial effects as follows: be different from the situation of prior art, Nipagin ester based composition aqueous dispersion provided by the invention includes: at least one and water, organic solvent and water in parabens material, organic solvent, amphoteric surfactant and nonionic surfactant can be miscible with arbitrary proportion。There is lipophilic group and hydrophilic group due to amphoteric surfactant, it not only contains positive charge but also contain negative charge in aqueous, Nipagin ester ion band negative electricity after ionizing in water, positive charge absorption easily and in amphoteric surfactant, increasing the intermolecular repulsive force of Nipagin ester, assembling thus reducing Nipagin ester；On the other hand, amphoteric surfactant makes the pH value of solution system raise, parabens material ionization equilibrium in water offsets to ionic state, increase the dissolving of parabens material, Nipagin ester compositions aqueous dispersion is made to reach the state of relative dynamic balance, so that this aqueous dispersion is stable and dispersibility is good；Nonionic surfactant does not dissociate when being dissolved in water, in water and organic solvent has good dissolubility, there is hydrophilic group and lipophilic group, lipophilic group is interacted by the hydrophobic group of molecular separating force with parabens material, parabens material is wrapped up, hydrophilic group and hydrone are interacted by hydrogen bond etc., so that parabens material also is able to be dissolved in water under the effect of nonionic surfactant in water, minimizing Nipagin ester gathering makes this aqueous dispersion stable and dispersibility is good。
Accompanying drawing explanation
Fig. 1 is the flow chart of Nipagin ester of the present invention composition dispersion system preparation method one embodiment。
Detailed description of the invention
Below in conjunction with drawings and embodiments, the present invention is described in detail。
The present invention provides a kind of Nipagin ester based composition aqueous dispersion, said composition aqueous dispersion includes: at least one in parabens material, organic solvent, amphoteric surfactant and nonionic surfactant and water, wherein, organic solvent and water can be miscible with arbitrary proportion, and the parabens material in compositions aqueous dispersion is uniformly dispersed and stable in water。
A kind of material or several material are highly dispersed in another kind of material (being called disperse medium) system formed and are called dispersion。
Parabens material is insoluble in water, is soluble in organic solvent。Parabens material mainly includes methyl hydroxybenzoate, ethyl hydroxybenzoate, propylparaben, butoben, iso-butyl p-hy-droxybenzoate etc.。
Organic solvent includes alcohol, ether, acetone etc.。Wherein, organic solvent is alcohol organic solvent。Alcohol organic solvent refers to the compound in molecule containing the hydroxyl combined with the carbon on chain alkylene or benzene ring side chain, and its functional group is-OH。Parabens material is soluble in alcohol organic solvent, the principle dissolved is the similar principle that mixes, namely alcohol organic solvent can be miscible with arbitrary proportion with water, in the solution system of alcohol and water composition, alcohol changes the polarity of water itself, this solution system polarity is made to diminish, parabens material is low polar substances, the polarity of the polarity of the solution system being therefore made up of alcohol and water and parabens material becomes closer to, thus realizing parabens material to be dissolved in the solution system being made up of alcohol and water。Wherein, alcohol organic solvent includes but not limited to propylene glycol, ethohexadiol, 1,3 butylene glycol, pentanediol, phenoxyethanol, hexanediol etc.。
Amphoteric surfactant refers to the surfactant with two kinds of ionic natures of yin, yang。There is lipophilic group and hydrophilic group due to amphoteric surfactant, it not only contains positive charge but also contain negative charge in aqueous, Nipagin ester ion band negative electricity after ionizing in water, positive charge absorption easily and in amphoteric surfactant, increasing the intermolecular repulsive force of Nipagin ester, assembling thus reducing Nipagin ester；On the other hand, amphoteric surfactant makes the pH value of solution system raise, parabens material ionization equilibrium in water offsets to ionic state, increase the dissolving of parabens material, Nipagin ester compositions aqueous dispersion is made to reach the state of relative dynamic balance, so that this aqueous dispersion is stable and dispersibility is good。
Wherein, amphoteric surfactant includes but not limited to betanin derivative, both sexes Acetates, propionate compound, 2-Sulfosuccinic acid salt etc.。
Nonionic surfactant refers to the surfactant not producing ion in aqueous。Nonionic surfactant does not dissociate when being dissolved in water, in water and organic solvent has good dissolubility, there is hydrophilic group and lipophilic group, lipophilic group is interacted by the hydrophobic group of molecular separating force with parabens material, parabens material is wrapped up, hydrophilic group and hydrone are interacted by hydrogen bond etc., so that parabens material also is able to be dissolved in water under the effect of nonionic surfactant in water, minimizing Nipagin ester gathering makes this aqueous dispersion stable and dispersibility is good。Nonionic surfactant includes but not limited to TWEEN Series, hydrogenated castor wet goods。
Wherein, the weight/mass percentage composition of parabens material is 0.01%～1%, for instance, the weight/mass percentage composition of parabens material can be 0.01%, 0.5% or 1%；Further, the weight/mass percentage composition of parabens material is 0.05%～0.7%, for instance the weight/mass percentage composition of parabens material can be 0.05%, 0.4% or 0.7%。
Wherein, the weight/mass percentage composition of alcohol organic solvent is 0.04%～15%, for instance, the weight/mass percentage composition of alcohol organic solvent is 0.04%, 7% or 15%；Further, the weight/mass percentage composition of alcohol organic solvent is 0.04%-10%, for instance, the weight/mass percentage composition of alcohol organic solvent is 0.04%, 5% or 10%。
Wherein, the weight/mass percentage composition of amphoteric surfactant is 0.01%～1%, for instance, the weight/mass percentage composition of amphoteric surfactant is 0.01%, 0.5% or 1%；Further, amphoteric surfactant weight/mass percentage composition is 0.05%～0.7%, for instance, the weight/mass percentage composition of amphoteric surfactant is 0.05%, 0.35% or 0.7%。
Wherein, the weight/mass percentage composition of nonionic surfactant is 0.04%～10%, for instance, the weight/mass percentage composition of nonionic surfactant is 0.04%, 5% or 10%；Further, nonionic surfactant weight/mass percentage composition is 0.2%～8%, for instance, the weight/mass percentage composition of nonionic surfactant is 0.2%, 4% or 8%。
Wherein, amphoteric surfactant includes at least one of betanin derivative, both sexes Acetates, propionate compound, sulfosuccinate apoplexy due to endogenous wind, namely can be betanin derivative, both sexes Acetates, propionate compound, the one of sulfosuccinate apoplexy due to endogenous wind, two kinds or above formed mixture。Further, amphoteric surfactant includes betanin derivative, both sexes Acetates and mixture thereof。
Wherein, betanin derivative includes cocamido propyl betaine, lauroyl CAB, octyl group/decylamidopropyl glycine betaine, ricinoleic acid amide CAB, dodecyl ethyoxyl sulfobetaines, dodecyl hydroxypropyl sulfobetaines, dodecyl sulfobetaine；Both sexes Acetates includes cocos nucifera oil both sexes sodium acetate, cocos nucifera oil both sexes diacetic acid disodium, Semen pruni armeniacae oil both sexes sodium acetate, cocoa butter both sexes sodium acetate；Propionate compound includes cocos nucifera oil both sexes sodium propionate；2-Sulfosuccinic acid salt includes Polyethylene Glycol-5 lauryl citric acid disodium sulfosuccinate, lauryl alcohol disodium sulfosuccinate, ricinoleic acid amide monoethanolamine disodium sulfosuccinate, lauryl disodium sulfosuccinate。
Wherein, nonionic surfactant includes at least one in TWEEN Series, castor oil hydrogenated。
Wherein, TWEEN Series includes tween 20, Tween-60, tween 80；Castor oil hydrogenated includes Cremophor RH40, PEG-60 castor oil hydrogenated。
The preparation method that the present invention also provides for a kind of Nipagin ester based composition aqueous dispersion, for preparing above-mentioned Nipagin ester based composition aqueous dispersion, refer to Fig. 1, Fig. 1 is the flow chart of preparation method one embodiment of Nipagin ester of the present invention composition dispersion system, and present embodiment dispersion preparation method includes:
Step S101: Nipagin ester based composition organic solvent dispersion system is provided, compositions organic solvent dispersion system includes: parabens material, organic solvent and amphoteric surfactant and at least one in nonionic surfactant, wherein, organic solvent and water can be miscible with arbitrary proportion。
Step S102: Nipagin ester based composition organic solvent dispersion system is under agitation added to the water, is formed and be uniformly dispersed and stable Nipagin ester based composition aqueous dispersion。
The Nipagin ester based composition organic solvent dispersion system obtained in step S101 is under agitation added to the water, stirs, form the dispersion of stable and uniform。
Parabens material is insoluble in water, is soluble in organic solvent。
Amphoteric surfactant refers to the surfactant with two kinds of ionic natures of yin, yang。There is lipophilic group and hydrophilic group due to amphoteric surfactant, it not only contains positive charge but also contain negative charge in aqueous, Nipagin ester ion band negative electricity after ionizing in water, positive charge absorption easily and in amphoteric surfactant, increasing the intermolecular repulsive force of Nipagin ester, assembling thus reducing Nipagin ester；On the other hand, amphoteric surfactant makes the pH value of solution system raise, parabens material ionization equilibrium in water offsets to ionic state, increase the dissolving of parabens material, Nipagin ester compositions aqueous dispersion is made to reach the state of relative dynamic balance, so that this aqueous dispersion is stable and dispersibility is good。
Nonionic surfactant refers to the surfactant not producing ion in aqueous。Nonionic surfactant does not dissociate when being dissolved in water, in water and organic solvent has good dissolubility, there is hydrophilic group and lipophilic group, lipophilic group is interacted by the hydrophobic group of molecular separating force with parabens material, parabens material is wrapped up, hydrophilic group and hydrone are interacted by hydrogen bond etc., so that parabens material also is able to be dissolved in water under the effect of nonionic surfactant in water, minimizing Nipagin ester gathering makes this aqueous dispersion stable and dispersibility is good。
Wherein, organic solvent is alcohol organic solvent。Alcohol organic solvent includes but not limited to propylene glycol, ethohexadiol, 1,3 butylene glycol, pentanediol, phenoxyethanol, hexanediol etc.。
Wherein, the weight/mass percentage composition of parabens material is 0.01%～1%, for instance, the weight/mass percentage composition of parabens material is 0.01%, 0.5% or 1%；Further, the weight/mass percentage composition of parabens material is 0.05%～0.7%, for instance, the weight/mass percentage composition of parabens material is 0.05%, 0.4% or 0.7%。
Wherein, the weight/mass percentage composition of alcohol organic solvent is 0.04%～15%, such as, the weight/mass percentage composition of alcohol organic solvent is 0.04%, 7% or 15%, further, the weight/mass percentage composition of alcohol organic solvent is 0.04%～10%, for instance, the weight/mass percentage composition of alcohol organic solvent is 0.04%, 5% or 10%。
Wherein, the weight/mass percentage composition of amphoteric surfactant is 0.01%～1%, such as, the weight/mass percentage composition of amphoteric surfactant is 0.01%, 0.5% or 1%, further, the weight/mass percentage composition of amphoteric surfactant is 0.05%～0.7%, for instance, the weight/mass percentage composition of amphoteric surfactant is 0.05%, 0.35% or 0.7%。
Wherein, the weight/mass percentage composition of nonionic surfactant is 0.04%～10%, such as, the weight/mass percentage composition of nonionic surfactant is 0.04%, 5% or 10%, further, the weight/mass percentage composition of nonionic surfactant is 0.2%～8%, for instance, the weight/mass percentage composition of nonionic surfactant is 0.2%, 4% or 8%。
Wherein, parabens material includes at least one in methyl hydroxybenzoate, ethyl hydroxybenzoate, propylparaben, butoben, iso-butyl p-hy-droxybenzoate, can be one of which, two kinds or above mixture, such as, parabens material is the mixture of the mixture of ethyl hydroxybenzoate or propylparaben or butoben and methyl hydroxybenzoate or ethyl hydroxybenzoate, propylparaben, butoben and iso-butyl p-hy-droxybenzoate。
Wherein, alcohol organic solvent include propylene glycol, ethohexadiol, 1, at least one in 3-butanediol, pentanediol, phenoxyethanol, hexanediol, can be one of which, two kinds or above mixture, such as, alcohol organic solvent is the mixture of the mixture of propylene glycol or propylene glycol and ethohexadiol or ethohexadiol, 1,3 butylene glycol, three kinds of materials of pentanediol。
Wherein, amphoteric surfactant includes at least one of betanin derivative, both sexes Acetates, propionate compound, sulfosuccinate apoplexy due to endogenous wind, namely can be betanin derivative, both sexes Acetates, propionate compound, sulfosuccinate apoplexy due to endogenous wind one, two kinds or above formed mixture。A progressive ground, amphoteric surfactant includes betanin derivative, both sexes Acetates and mixture thereof。
Wherein, betanin derivative includes cocamido propyl betaine, lauroyl CAB, octyl group/decylamidopropyl glycine betaine, ricinoleic acid amide CAB, dodecyl ethyoxyl sulfobetaines, dodecyl hydroxypropyl sulfobetaines, dodecyl sulfobetaine；Both sexes Acetates includes cocos nucifera oil both sexes sodium acetate, cocos nucifera oil both sexes diacetic acid disodium, Semen pruni armeniacae oil both sexes sodium acetate, cocoa butter both sexes sodium acetate；Propionate compound includes cocos nucifera oil both sexes sodium propionate；Described 2-Sulfosuccinic acid salt includes Polyethylene Glycol-5 lauryl citric acid disodium sulfosuccinate, lauryl alcohol disodium sulfosuccinate, ricinoleic acid amide monoethanolamine disodium sulfosuccinate, lauryl disodium sulfosuccinate。
Wherein, nonionic surfactant includes at least one in TWEEN Series, castor oil hydrogenated。
Wherein, TWEEN Series includes tween 20, Tween-60, tween 80；Castor oil hydrogenated includes Cremophor RH40, PEG-60 castor oil hydrogenated。
Below by detailed description of the invention, Nipagin ester compositions aqueous dispersion of the present invention and preparation method are described further。
Matched group 1
Weigh 0.12 gram of (g) methyl hydroxybenzoate, 0.05 gram of ethyl hydroxybenzoate and 0.03 gram of propylparaben standby。Weigh 99.8 grams of water, add water in allotment bucket, then in allotment bucket, be under agitation sequentially added into above-mentioned 0.12 gram of methyl hydroxybenzoate, 0.05 gram of ethyl hydroxybenzoate and 0.03 gram of propylparaben, it is thus achieved that the Nipagin ester compositions aqueous dispersion of matched group 1。With the rotating speed of 400 rpms (400r/min), the Nipagin ester compositions aqueous dispersion of matched group 1 being stirred, stirring finds after terminating: having a large amount of granule to precipitate out, therefore, the method for matched group 1 can not form uniform dispersion。
Matched group 2
Weighing 0.12 gram of (g) methyl hydroxybenzoate, 0.05 gram of ethyl hydroxybenzoate, 0.03 gram of propylparaben is standby；Weigh 6 grams of propylene glycol standby。Being sequentially added into 0.12 gram of methyl hydroxybenzoate in small beaker, 0.05 gram of ethyl hydroxybenzoate, 0.03 gram of propylparaben is standby, 6 grams of propylene glycol, stirs。Standby。Weigh 93.8 grams of water, add in allotment bucket, above-mentioned parabens and propylene glycol mixture are added in allotment bucket, adds while stirring。The Nipagin ester compositions aqueous dispersion of matched group 2 is stirred by the rotating speed of speed of agitator 400 rpms (400r/min), and stirring finds after terminating: more granule precipitates out, it is impossible to form finely dispersed dispersion。
Embodiment 1
Weighing 0.12 gram of methyl hydroxybenzoate, 0.05 gram of ethyl hydroxybenzoate, 0.03 gram of propylparaben is standby；Weigh 3 grams of propylene glycol standby；Weigh 0.2 gram of Semen pruni armeniacae both sexes sodium acetate standby。Being sequentially added into above-mentioned 0.12 gram of methyl hydroxybenzoate, 0.05 gram of ethyl hydroxybenzoate, 0.03 gram of propylparaben, 3 grams of propylene glycol, 0.2 gram of Semen pruni armeniacae both sexes sodium acetate in small beaker, stirring is to being completely dissolved, standby。Weigh 96.6 grams of water, add water in allotment bucket, start stirring, stock is become to add the liquid in above-mentioned small beaker while stirring, the Nipagin ester compositions aqueous dispersion of embodiment 1 is stirred by the rotating speed of rotating speed 200 rpms (200r/min), stirring finds after terminating: clarification, precipitates out without granule, forms stable finely dispersed dispersion。
Embodiment 2
Weighing 0.12 gram of methyl hydroxybenzoate, 0.05 gram of ethyl hydroxybenzoate, 0.03 gram of propylparaben is standby；Weigh 3 grams of butanediols standby；Weigh 0.15 gram of cocamido propyl betaine standby。Being sequentially added into above-mentioned 0.12 gram of methyl hydroxybenzoate, 0.05 gram of ethyl hydroxybenzoate, 0.03 gram of propylparaben, 3 grams of butanediols, 0.15 gram of cocamido propyl betaine in small beaker, stirring is to being completely dissolved, standby。Weigh 96.65 grams of water, add water in allotment bucket, start stirring, stock is become to add the liquid in above-mentioned small beaker while stirring, the Nipagin ester compositions aqueous dispersion of embodiment 2 is stirred by the rotating speed of rotating speed 200 rpms (200r/min), stirring finds after terminating: clarification, precipitates out without granule, forms stable finely dispersed dispersion。
Embodiment 3
Weighing 0.2 gram of methyl hydroxybenzoate, 0.08 gram of ethyl hydroxybenzoate, 0.02 gram of butoben is standby；Weigh 3.5 grams hexylene glycol standby；Weigh 0.3 gram of octyl group amido propyl betaine standby。Being sequentially added in small beaker and above-mentioned take 0.2 gram of methyl hydroxybenzoate, 0.08 gram of ethyl hydroxybenzoate, 0.02 gram of butoben is standby, and 3.5 grams hexylene glycol are standby, 0.3 gram of octyl group amido propyl betaine, and stirring is to being completely dissolved, standby。Weigh 95.9 grams of water, add water in allotment bucket, start stirring, stock is become to add the liquid in small beaker while stirring, the Nipagin ester compositions aqueous dispersion of embodiment 3 is stirred by the rotating speed of rotating speed 200 rpms (200r/min), stirring finds after terminating: clarification, precipitates out without granule, forms stable finely dispersed dispersion。
Embodiment 4
Weighing 0.12 gram of methyl hydroxybenzoate, 0.05 gram of ethyl hydroxybenzoate, 0.03 gram of propylparaben is standby；Weigh 3 grams of propylene glycol standby；Weigh 3 grams of Cremophor RH40s standby。Being sequentially added into above-mentioned 0.12 gram of methyl hydroxybenzoate, 0.05 gram of ethyl hydroxybenzoate, 0.03 gram of propylparaben, 3 grams of propylene glycol, 3 grams of Cremophor RH40s in small beaker, stirring is to being completely dissolved, standby。Weigh 93.8 grams of water, add water in allotment bucket, start stirring, stock is become to add the liquid in above-mentioned small beaker while stirring, the Nipagin ester compositions aqueous dispersion of embodiment 4 is stirred by the rotating speed of rotating speed 200 rpms (200r/min), stirring finds after terminating: clarification, precipitates out without granule, forms stable finely dispersed dispersion。
Embodiment 5
Weighing 0.25 gram of methyl hydroxybenzoate, 0.08 gram of ethyl hydroxybenzoate, 0.04 gram of propylparaben, 0.02 gram of butoben is standby；Weighing 2 grams of propylene glycol, 3 grams of butanediols are standby；Weighing 0.2 gram of Semen pruni armeniacae both sexes sodium acetate, 0.2 gram of certain herbaceous plants with big flowers base amido propyl betaine is standby。Small beaker is sequentially added into above-mentioned 0.25 gram of methyl hydroxybenzoate, weigh 0.08 gram of ethyl hydroxybenzoate, weigh 0.04 gram of propylparaben, weigh 0.02 gram of butoben, sequentially add 2 grams of propylene glycol, 3 grams of butanediols, finally it is sequentially added into 0.2 gram of Semen pruni armeniacae both sexes sodium acetate, 0.2 gram of certain herbaceous plants with big flowers base amido propyl betaine, stirring is to being completely dissolved, standby。Weigh 94.21 grams of water, add water in allotment bucket, start stirring, stock is become to add the liquid in small beaker while stirring, the Nipagin ester compositions aqueous dispersion of embodiment 5 is stirred by the rotating speed of rotating speed 200 rpms (200r/min), stirring finds after terminating: clarification, precipitates out without granule, forms stable finely dispersed dispersion。
Above-mentioned matched group 1 to 2, embodiment 1 to 5 experimental result, referring to table 1。
Table 1
As it can be seen from table 1 under identical parabens consumption, such as embodiment 2, in embodiment 4, alcohol organic solvent and surfactant are simultaneously introduced, and under relatively low rotating speed, are directly added in water, also precipitate out without granule, and rotation speed requirements is low, and water solublity is more preferably。Alcohol organic solvent and surfactant are used in conjunction with, and reach identical water solublity effect, and both consumption sums are far smaller than the amount individually only using alcohol organic solvent。The consumption that makes of each parabens material can also distinguish suitable raising, makes inhibitor effectiveness increase。
The foregoing is only embodiments of the present invention; not thereby the scope of the claims of the present invention is limited; every equivalent structure utilizing description of the present invention to make or equivalence flow process conversion; or directly or indirectly it is used in other relevant technical field, all in like manner include in the scope of patent protection of the present invention。
Claims (24)
1. a Nipagin ester based composition aqueous dispersion, it is characterized in that, described compositions aqueous dispersion includes: at least one in parabens material, organic solvent, amphoteric surfactant and nonionic surfactant and water, wherein, described organic solvent and described water can be miscible with arbitrary proportion, and the parabens material in described compositions aqueous dispersion is uniformly dispersed and stable in described water。
2. compositions aqueous dispersion according to claim 1, it is characterised in that described organic solvent is alcohol organic solvent。
3. compositions aqueous dispersion according to claim 2, it is characterised in that the weight/mass percentage composition of described parabens material is 0.01%～1%。
4. compositions aqueous dispersion according to claim 2, it is characterised in that the weight/mass percentage composition of described alcohol organic solvent is 0.04%～15%。
5. compositions aqueous dispersion according to claim 2, it is characterised in that the weight/mass percentage composition of described amphoteric surfactant is 0.01%～1%。
6. compositions aqueous dispersion according to claim 2, it is characterised in that the weight/mass percentage composition of described nonionic surfactant is 0.04%～10%。
7. the compositions aqueous dispersion according to any one of claim 2 to 6, it is characterised in that described alcohol organic solvent includes at least one in propylene glycol, ethohexadiol, 1,3 butylene glycol, pentanediol, phenoxyethanol, hexanediol。
8. the compositions aqueous dispersion according to any one of claim 2 to 6, it is characterised in that described amphoteric surfactant includes at least one of betanin derivative, both sexes Acetates, propionate compound, sulfosuccinate apoplexy due to endogenous wind。
9. compositions aqueous dispersion according to claim 8, it is characterised in that described amphoteric surfactant is betanin derivative, both sexes Acetates or its mixture。
10. compositions aqueous dispersion according to claim 8; it is characterized in that, described betanin derivative includes cocamido propyl betaine, lauroyl CAB, octyl group/decylamidopropyl glycine betaine, ricinoleic acid amide CAB, dodecyl ethyoxyl sulfobetaines, dodecyl hydroxypropyl sulfobetaines, dodecyl sulfobetaine；Described both sexes Acetates includes cocos nucifera oil both sexes sodium acetate, cocos nucifera oil both sexes diacetic acid disodium, Semen pruni armeniacae oil both sexes sodium acetate, cocoa butter both sexes sodium acetate；Described propionate compound includes cocos nucifera oil both sexes sodium propionate；Described 2-Sulfosuccinic acid salt includes Polyethylene Glycol-5 lauryl citric acid disodium sulfosuccinate, lauryl alcohol disodium sulfosuccinate, ricinoleic acid amide monoethanolamine disodium sulfosuccinate, lauryl disodium sulfosuccinate。
11. the compositions aqueous dispersion according to any one of claim 2 to 6, it is characterised in that described nonionic surfactant includes at least one in TWEEN Series, castor oil hydrogenated。
12. compositions aqueous dispersion according to claim 11, it is characterised in that described TWEEN Series includes tween 20, Tween-60, tween 80；Described castor oil hydrogenated includes Cremophor RH40, PEG-60 castor oil hydrogenated。
13. the preparation method of a Nipagin ester based composition aqueous dispersion, it is characterised in that described method includes:
Nipagin ester based composition organic solvent dispersion system is provided, described compositions organic solvent dispersion system includes: parabens material, organic solvent and amphoteric surfactant and at least one in nonionic surfactant, wherein, described organic solvent and water can be miscible with arbitrary proportion；
Described Nipagin ester based composition organic solvent dispersion system is under agitation added to the water, is formed and be uniformly dispersed and stable Nipagin ester based composition aqueous dispersion。
14. method according to claim 13, it is characterised in that described organic solvent is alcohol organic solvent。
15. method according to claim 14, it is characterised in that the weight/mass percentage composition of described parabens material is 0.01%～1%。
16. method according to claim 14, it is characterised in that the weight/mass percentage composition of described alcohol organic solvent is 0.04%～15%。
17. method according to claim 14, it is characterised in that the weight/mass percentage composition of described amphoteric surfactant is 0.01%～1%。
18. method according to claim 14, it is characterised in that the weight/mass percentage composition of described nonionic surfactant is 0.04%～10%。
19. according to the method described in any one of claim 14 to 18, it is characterised in that described alcohol organic solvent includes at least one in propylene glycol, ethohexadiol, 1,3 butylene glycol, pentanediol, phenoxyethanol, hexanediol。
20. according to the method described in any one of claim 14 to 18, it is characterised in that described amphoteric surfactant includes at least one of betanin derivative, both sexes Acetates, propionate compound, sulfosuccinate apoplexy due to endogenous wind。
21. method according to claim 20, it is characterised in that described amphoteric surfactant is betanin derivative, both sexes Acetates or its mixture。
22. method according to claim 20; it is characterized in that, described betanin derivative includes cocamido propyl betaine, lauroyl CAB, octyl group/decylamidopropyl glycine betaine, ricinoleic acid amide CAB, dodecyl ethyoxyl sulfobetaines, dodecyl hydroxypropyl sulfobetaines, dodecyl sulfobetaine；Described both sexes Acetates includes cocos nucifera oil both sexes sodium acetate, cocos nucifera oil both sexes diacetic acid disodium, Semen pruni armeniacae oil both sexes sodium acetate, cocoa butter both sexes sodium acetate；Described propionate compound includes cocos nucifera oil both sexes sodium propionate；Described 2-Sulfosuccinic acid salt includes Polyethylene Glycol-5 lauryl citric acid disodium sulfosuccinate, lauryl alcohol disodium sulfosuccinate, ricinoleic acid amide monoethanolamine disodium sulfosuccinate, lauryl disodium sulfosuccinate。
23. according to the method described in any one of claim 14 to 18, it is characterised in that described nonionic surfactant includes at least one in TWEEN Series, castor oil hydrogenated。
24. method according to claim 23, it is characterised in that described TWEEN Series includes tween 20, Tween-60, tween 80；Described castor oil hydrogenated includes Cremophor RH40, PEG-60 castor oil hydrogenated。
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