CN1056759C

CN1056759C - Traditional Chinese medicine preparation for prevention and treatment of hepatitis B

Info

Publication number: CN1056759C
Application number: CN95103883A
Authority: CN
Inventors: 张立中
Original assignee: Individual
Current assignee: Individual
Priority date: 1995-04-24
Filing date: 1995-04-24
Publication date: 2000-09-27
Anticipated expiration: 2015-04-24
Also published as: CN1112018A

Abstract

The present invention discloses medicament for preventing and treating hepatitis B, which is in the form of tea, instant granules, oral liquid, etc. which is prepared from astragalus root, Chinese angelica root, wolfberry fruit, giant knotweed rhizome, China root, honeycomb, Chinese caterpillar fungus, glossy privet fruit, cimicifuga root and liquoric root.

Description

The Chinese medicine preparation of a kind of prevention and treatment hepatitis B

The present invention is the Chinese medicine of a kind of prevention and treatment hepatitis B and hepatitis B virus carriers.Specifically, relating to the Chinese herbal medicine is the Chinese drugs agentia with prevention and treatment hepatitis B and hepatitis B virus carriers that raw material is made, and comprises medicinal tea, electuary, oral liquid etc.

There are 1.2 hundred million people to carry hepatitis B virus approximately in China, 1,500 ten thousand chronic hepatitis B patients are arranged approximately.In a single day people infect hepatitis B virus, must carry out the practice of each person having an individual portion of food, and active treatment.No matter be hepatitis B virus carriers, or hepatitis B patient, the healthy of people all seriously endangered.The person of being in a bad way develops into liver cirrhosis, and part patient finally develops into hepatocarcinoma, jeopardizes people's life.The medical personnel of countries in the world is endeavouring to study the medicine of seeking the treatment hepatitis B, up to the present also do not treat the specific medicament of hepatitis B, therefore, the method of taking in treatment and the medicine of use have nothing in common with each other, generally all be symptomatic treatment, adopt and protect the liver, fall enzyme, press down measures such as poison.Commonly usedly clinically at present fall enzyme medicine Fructus Schisandrae Chinensis preparation and bifendate, though the transaminase lowering effect is very fast, the knock-on rate is up to more than 60%, and, jaundice turbid to Moschus moschiferous and Australia antigen are turned out cloudy and do not had obviously effect; Hepatic glucuronolatone commonly used, coenzyme A, inosine etc. and anti-hepatitis virus medicament interferon etc. can make the part patient, and HBsAg, HBeAg turn out cloudy or titre descends, in case but drug withdrawal, easily knock-on is multiple rises, and can not suppress hepatitis B virus enduringly.Thereby make the hepatitis B patient long-term prescription of having to.Factors such as drug treatment is grown, cost an arm and a leg, medicine-feeding way inconvenience make vast loyal person be difficult to accept whole-course treatment.Sb.'s illness took a turn for the worse because of affecting treatment adversely to cause most patients.Seek a kind of effectively and the medicine of taking convenience to be most of hepatitis B patient press for.CN1083712A discloses a kind of medicine of preventing and treating hepatitis B, and this medicine is made up of nine flavor Chinese medicines such as the Radix Astragali, Radix Pseudostellariae, Fructus Lycii, Radix Bupleuri, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Rhizoma Polygoni Cuspidati, Herba Hedyotidis Diffusae, Radix Et Rhizoma Rhei, and has reached certain therapeutic effect.CN1085446A discloses a kind of hepatitis B virus converting negative tablet, and this medicine is that Rhizoma Coptidis, Rhizoma Polygoni Cuspidati, Cordyceps, Radix Glycyrrhizae are mixed by a certain percentage, makes tablet through cleaning, dry, pulverizing.Although above-mentioned two kinds of Chinese medicines have certain inhibitory action for hepatitis B virus, and obtained curative effect preferably, but owing to contain bitter cold antidote Radix Et Rhizoma Rhei, Rhizoma Coptidis in above-mentioned two kinds of medicines, and most of hepatitis B patient shows as insufficiency of the spleen symptom, take the bitter cold medicine can damage in burnt yang-energy, increase the weight of the insufficiency of the spleen state of an illness, thereby for insufficiency of the spleen hepatitis B patient, be not suitable for taking above-mentioned two kinds of medicines.The inventor cooperates patient's needs through long-term clinical observation, has developed a kind of taking convenience and the Chinese medicine medicinal tea of respond well treatment hepatitis B.

Therefore, the object of the invention provides a kind of active drug for the treatment of hepatitis B and hepatitis B virus carriers.

Another object of the present invention provides a kind of taking convenience and the Chinese medicine medicinal tea of the treatment hepatitis B accepted by hepatitis B patient easily.

Medicine of the present invention is to be made by the Radix Astragali, Radix Angelicae Sinensis, Fructus Lycii, Rhizoma Polygoni Cuspidati, Rhizoma Smilacis Glabrae, Nidus Vespae, Cordyceps, RHIIZOMA CIMICIFUGAE, Fructus Ligustri Lucidi, Radix Glycyrrhizae.

Pharmaceutical compositions compositing range of the present invention is:

Radix Astragali 10-15 gram Radix Angelicae Sinensis 5-10 gram Fructus Lycii 5-10 gram

Rhizoma Polygoni Cuspidati 10-15 gram Rhizoma Smilacis Glabrae 8-12 gram Nidus Vespae 4-8 gram

Cordyceps 4-10 gram RHIIZOMA CIMICIFUGAE 3-5 gram Fructus Ligustri Lucidi 5-10 gram

Radix Glycyrrhizae 5-10 gram

The preferred weight proportioning of pharmaceutical formulation each component of the present invention is:

The Radix Astragali 15%, Radix Angelicae Sinensis 10%, Fructus Lycii 10%, Rhizoma Polygoni Cuspidati 15%, Rhizoma Smilacis Glabrae 10%,

Nidus Vespae 5%, Cordyceps 10%, RHIIZOMA CIMICIFUGAE 5%, Fructus Ligustri Lucidi 10%, Radix Glycyrrhizae 10%

The processing technique of medicine medicinal tea of the present invention is:

The said herbal medicine crude drug of formula ratio is chosen decontamination, mix, dry, pulverize, sieve, in the sterilising filtration tea bag of packing into, seal promptly, have the short-term that leads drawings on the tea bag.

Medicine of the present invention can also be made conventional pharmaceutical dosage form except being made into above-mentioned medicinal tea place, as electuary, and oral liquid, tablet, capsule etc.

The preparation technology of medicine instant of the present invention is:

By above-mentioned formula ratio, the herbal raw material medicine is chosen decontamination, mixed powder is broken into coarse powder (5-10 order), put into extraction pot, the water that adds 3 times of amounts of crude drug weight boils back slow fire and boiled one hour again, leaches medicinal liquid, and then the water of adding Chinese herbal medicine weight qdx, boil back slow fire and boil half an hour again, leach medicinal liquid, front and back secondary medicinal liquid is merged, the cooling back adds 1-2 and doubly measures fully mixing placement of ethanol (concentration 90%), precipitation.Get its supernatant after 20 hours, precipitate is cleaned with a small amount of 50-60% ethanol, washing liquid and filtrate merge, decompression recycling ethanol, after being concentrated to finite concentration, cooling was left standstill 12 hours again, made thorough precipitation, filtration, the filtrate low-temperature evaporation is standby to the thick paste shape, and the ratio of thick paste is reheated survey (80-90 ℃) for 1.30-1.35.Wear into fine powder with crystallization of sucrose, it is standby to cross the 80-100 mesh sieve, and it is standby to get commercially available dextrin, and Chinese herb medicine thick paste, Icing Sugar, dextrin are got finished product by 1: 3: 1 weight ratio stirring and evenly mixing.

The preparation technology of oral liquid of the present invention is:

According to preparation identical prepared Chinese herbal medicine thick paste during electuary, with an amount of distilled water diluting of thick paste, filter, it is 20% that diluent contains the crude drug amount, add simple syrup, Pyrusussuriensis potassium alcoholate (content should be up to specification by 90 years version pharmacopeia) sterilization, be packaged in 10ml oral liquid ampoule (up to specification), make the oral liquid finished product by requirement under 90 years version oral liquid items.

Medicine of the present invention has function of resisting hepatitis B virus, can improve immune function, and preventing cold is arranged, and increases the effect of appetite.Take medicated tea observation of the present invention through 120 routine hepatitis patients or hepatitis B virus carriers, effective percentage 98%, antigen of hepatitis B virus negative conversion rate HBsAg33.7%, HBeAg48.8% generally was one with three months and takes medicine the course of treatment that the elder can reach 1 year.

Model case

Example 1: man 32 years old, chronic persistent hepatitis.Suffered from hepatitis B 6 years, the recurrence in every year, ALT often fluctuation often catches a cold inappetence about 100U.HBsAg, HBeAg are all positive, and through obeying this tea nearly 3 years, two antigens are all turned out cloudy, and two and half do not catch a cold.Household's secondary flu before and after New Year's Day in 1994, only this patient escapes by luck.The more preceding remarkable increase of appetite.Liver function 2 years is normal.

Example 2: woman 26 years old, chronic persistent hepatitis SGPT fluctuates between 300-400U, and HBsAg, HBeAg are all positive.Hospitalization two months is not more left hospital because of economic cause.Consider inexpensive and take this tea.Drinking tea through 2 years, two antigens are all cloudy to be changeed.The now anti-HBc positive, liver function a year and a half normal, two antigens are cloudy to be changeed more than 1 year.Do not catch a cold behind the clothes tea, the more preceding increase of appetite, energy is more preceding abundant.

Embodiment:

Get 15 kilograms of 10 kilograms of Rhizoma Polygoni Cuspidati of 10 kilograms of Fructus Lycii of 15 kilograms of Radix Angelicae Sinensis of the Radix Astragali,

5 kilograms of 10 kilograms of RHIIZOMA CIMICIFUGAEs of 5 kilograms of Cordyceps of 10 kilograms of Nidus Vespae of Rhizoma Smilacis Glabrae

10 kilograms in 10 kilograms of Radix Glycyrrhizaes of Fructus Ligustri Lucidi

The above-mentioned raw materials medicine is chosen decontamination, and oven dry is pulverized, and sieves, and packs into to go out in the filtration tea bag of castor, makes 100 kilograms of teabag finished products.

Claims

One kind the prevention and the treatment hepatitis B Chinese medicine preparation, it is characterized in that said composition is to be made by the following raw material medicaments thing:

Radix Astragali 10-15 gram Radix Angelicae Sinensis 5-10 gram Fructus Lycii 5-10 gram

Rhizoma Polygoni Cuspidati 10-15 gram Rhizoma Smilacis Glabrae 8-12 gram Nidus Vespae 4-8 gram

Cordyceps 4-10 gram RHIIZOMA CIMICIFUGAE 3-5 gram Fructus Ligustri Lucidi 5-10 gram

Radix Glycyrrhizae 5-10 gram.
2. medicament according to claim 1 is characterized in that the percentage by weight of each component is:

The Radix Astragali 15%, Radix Angelicae Sinensis 10%, Fructus Lycii 10%, Rhizoma Polygoni Cuspidati 15%, Rhizoma Smilacis Glabrae 10%, Nidus Vespae 5%, Cordyceps 10%, RHIIZOMA CIMICIFUGAE 5%, Fructus Ligustri Lucidi 10%, Radix Glycyrrhizae 10%.
3. medicament according to claim 1 and 2 is characterized in that it is medicinal tea or electuary or oral liquid formulation.
4. the preparation method of the described medicament electuary of claim 3 is characterized in that the crude drug of formula ratio is pulverized, decocted with water, and the gained medicinal liquid is condensed into thick paste, adds Icing Sugar, dextrin, and mixing makes finished product.
5. preparation method according to claim 4 is characterized in that the Chinese herbal medicine dry product of formula ratio is ground into coarse powder, add the water boil one hour of crude drug weight triplication, go out medicinal liquid, add qdx water boil half an hour again, go out medicinal liquid, the secondary medicinal liquid merges, and the cooling back adds 1-2 and doubly measures the ethanol mixing, place post precipitation and get supernatant, reclaim ethanol, concentrated supernatant, leave standstill, filter, flash to paste, with thick paste, Icing Sugar, dextrin ratio mixing, make finished product in 1: 3: 1.
6. the preparation method of the described oral liquid of claim 3 is characterized in that the Chinese herbal medicine dry product of formula ratio is ground into coarse powder, add the water boil one hour of crude drug weight triplication, go out medicinal liquid, add qdx water boil half an hour again, go out medicinal liquid, the secondary medicinal liquid merges, and the cooling back adds 1-2 and doubly measures the ethanol mixing, places post precipitation and gets supernatant, reclaim ethanol, concentrated supernatant leaves standstill, and filters, flash to paste, add distilled water diluting, make diluent contain crude drug amount 20%, add simple syrup again, the Pyrusussuriensis potassium alcoholate, dosage by 90 years version pharmacopeia regulations, filter sterilization, encapsulation.