CN101011470B - Traditional Chinese medicine compound composition for treating hepatitis - Google Patents
Traditional Chinese medicine compound composition for treating hepatitis Download PDFInfo
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Abstract
Disclosed is a Chinese medicinal compound composition for treating hepatitis which comprises the following constituents: giant knotweed rhizome 100-350 parts, phyllanthus urinaria 100-400 parts, basket fern 100-250 parts, schisandra fruit 100-250 parts, radix isatidis 80-200 parts, schisandra fruit 80-200 parts, ligustrum japonicum 80-200 parts, red sage root 80-200 parts, ganoderma lucidum 50-150 parts, astragalus root 100-350 parts. The preparing process consists of water extracting, grilling, filtering and concentrating to obtain the corresponding medicinal dose forms.
Description
Technical field
The present invention relates to field of medicaments, relate to a kind of Chinese medicine compound compositions that is used for the treatment of hepatitis specifically.
Background technology
Hepatitis B is the very wide infectious disease of world pop, and especially wide in China's propagation, infected crowd is many, and on average more than 10%, the whole world has 3.5 hundred million, estimates that China's hepatitis B patient or hepatitis B virus carriers are about 1.5 hundred million, is a huge patient group.Hepatitis B virus parasitizes constantly breeding in the host liver cell, and hepatocyte is produced prolonged destruction of not healing, patient's body constitution is reduced gradually, work is lost gradually with ability to work, and the part hepatitis B patient can cause the hepatocyte malignant change, causes PLC mortality eventually.So hepatitis B really is " formidable enemy " of human health.
In view of the characteristics of hepatitis B virus, determine it to have repeatability, persistency and intractable in human liver cell endoparasitism, breeding.Chemical drugs is rapid-action, but toxicity is big, relapse rate is high, easy drug resistance, and chemicals is the leading products of clinical practice.Chinese medicine, crude drug preparation, there is multiple product in market, but the drug application of determined curative effect, formation scale is also found so far.
Chronic type B viral hepatitis is very high at the sickness rate of China, and still lacks the specific treatment method at present, and main treatment is at etiologic etiological antiviral therapy and the treatment of the liver protecting and ALT lowering jaundice eliminating.
(1) Western medicine antiviral drugs commonly used has interferon-alpha and nucleotide analog lamivudine, though two medicines have curative effect preferably, but two medicinal medicines have strict indication and more serious drug reaction, must under the situation that the transaminase increases, use, and cost an arm and a leg some medicine course of treatment even up to tens thousand of units.
(2) treatment by Chinese herbs:
At present, Western medicine often adopts " antiviral drugs " on hepatopathy, and the traditional Chinese medical science is emphasized determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs." prevention and treatment for chronic hepatitis B guide " standard according to up-to-date announcement: having only the transaminase is more than 2 times of normal value, and the patient that hepatitis B virus DNA is positive just need accept antiviral therapy.Therefore, Most patients need adopt hepatoprotective, prevents this treatment means of self regulating of hepatic fibrosis, and this advantage of Chinese medicine just.Even in authority's hepatopathy doctor trained in Western medicine monograph, also all Chinese medicine is introduced considerable length, some Chinese medicine preparation, as KUHUANG ZHUSHEYE, Fructus Schisandrae Chinensis preparation, Radix Glycyrrhizae class preparation, kurarinone etc. all as the main medication of hepatitis.Patient is generally approval also, uses side effect not obvious for a long time, low many of price, and its advantage is conspicuous.Brought wide prospect therefore for the treatment by Chinese herbs hepatitis B.
Of a great variety, the enormous amount of Chinese medicine preparation, its advantage is that low price, side effect are little etc., but, relative Western medicine, antiviral effectiveness is not enough, and the mechanism of action is indeterminate, in recent years, along with studies show that of deepening continuously, many Chinese medicines have the effect that suppresses HBV, have as HBsAg being had stronger inhibiting Chinese medicine: Rhizoma Osmundae, Rhizoma Dioscoreae Bulbiferae, Rhizoma Polygoni Cuspidati, Herba Hedyotidis Diffusae etc.HBV-DNA had obviously inhibitingly to be had: Radix Sophorae Tonkinensis, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Radix Polygoni Multiflori, Herba Patriniae etc.The selected determined curative effect of the present invention, the clear and definite Chinese prescription of modern pharmacology; both can suppress, remove the hepatitis B virus population, adjust immunologic function, can protect and nourish hepatocyte again; promote hepatocellular regeneration; improve microcirculation in the liver, reduce fibrosis, this product nourishing the liver flavour of a drug are used few; do not increase burden of liver; reach antiviral, improved immunity, recovered the liver function three and develop simultaneously, can obtain lasting curative effect, final thoroughly rehabilitation.
Summary of the invention
Purpose of the present invention just at present, the deficiency of Western medicine, the Chinese medicine compound compositions of a kind of determined curative effect that special development provides, easy to use, the treatment hepatitis that has no side effect.
Hepatitis B is the doctor trained in Western medicine name of disease, the many categories that it reduced " hypochondriac pain ", " jaundice ", " lump in the abdomen " of the traditional Chinese medical science.Clinically show as lustreless complexion or dark and gloomy more, difficulty falling asleep or dreaminess, dull pain in liver or heavy, fatigue and weak, loss of appetite appear in patient, the abdominal distention of feeling sick, stool are not well, yellowish fur, dimly red tongue, pulse condition stringy and rapid pulse.Hepatitis B virus infection, tcm causa morbi are that noxious dampness is subjected to outward, transfer to chronicly, are positive QI-insufficiency, and be eliminating evil unable, lies prostrate due to the blood system.The epidemic disease caused by damp-heat pathogen poison belongs to the sticking turbid touching pathological process of a kind of damp, and has infectivity.In hepatopath's whole pathological process, because damp and hot bridle of a specified duration, it is turbid to grow expectorant, and the turbid resistance network of expectorant causes blood stasis.According to this rule, the present invention in clinical use for many years, hepatitis B strengthening capsule safely and effectively, the hepatitis B health, on the basis of prescriptions such as Herba Phyllanthi Urinariae hepatitis B capsules " Weishukang " for curing, an insidiousness that has at virus and hepatitis B patient's immunologic tolerance two big medical difficult problems, administer opinion based on traditional differential diagnosis in tcm opinion, introduce the series of studies understanding of modern medicine to hepatitis, scientifically select for use medicine to carry out prescription (medicine is taken no renal damage for a long time), the liver heat removing rule of treatment is proposed, break immunologic tolerance, too many levels, the multi-level treatment theory that reaches many target spots, develop Chinese medicine and regulate immunity, the advantage of antitoxin softening fine liver has remedied the single deficiency of other similar Drug therapys.
Therefore, the present invention adopts Rhizoma Polygoni Cuspidati, Cacumen Securinegae Suffruticosae, Rhizoma Osmundae, Galla Chinensis, Radix Isatidis, Fructus Schisandrae Chinensis, Fructus Ligustri Lucidi, Radix Salviae Miltiorrhizae, Ganoderma, the scientific and reasonable compatibility of the Radix Astragali, adopts advanced process for refining to process the traditional Chinese compound medicine of treatment hepatitis.
The objective of the invention is to realize by following scheme: the Chinese medicine compound compositions that the present invention treats hepatitis comprises the ingredient of following weight proportion:
Rhizoma Polygoni Cuspidati 100-350 part, Cacumen Securinegae Suffruticosae 100-400 part, Rhizoma Osmundae 100-250 part, Galla Chinensis 100-250 part, Radix Isatidis 80-200 part, Fructus Schisandrae Chinensis 80-200 part, Fructus Ligustri Lucidi 80-200 part, Radix Salviae Miltiorrhizae 80-200 part, Ganoderma 50-150 part, Radix Astragali 100-350 part.
The preferable amount of the present composition is: 300 parts of Rhizoma Polygoni Cuspidati, 300 parts of Cacumen Securinegae Suffruticosaes, 150 parts of Rhizoma Osmundae, 150 parts of Galla Chinensiss, 100 parts of Radix Isatidis, 100 parts of Fructus Schisandrae Chinensis, 100 parts of Fructus Ligustri Lucidi, 100 parts of Radix Salviae Miltiorrhizaes, 120 parts of Ganodermas, 300 parts of the Radixs Astragali.
Compositions of the present invention adopts modern Chinese medicine preparation technology to produce, and can be said any dosage form, i.e. granule, tablet, capsule, soft capsule etc. on the pharmaceutics.
Preparation method of the present invention comprises following processing step:
A, be ready to raw material,, run through, cut sheet Rhizoma Polygoni Cuspidati, Radix Isatidis, Radix Salviae Miltiorrhizae, the Radix Astragali by its proportioning; The Rhizoma Osmundae remove impurity, chopping; Galla Chinensis, Fructus Schisandrae Chinensis, Fructus Ligustri Lucidi, remove impurity.With the medical material of handling well, add for the first time 8 times of water gagings and decocted 2 hours, add 6 times of water gagings respectively and decocted 1.5 hours for two, three times.Decoction liquor is concentrated into relative density 1.25-1.30 (60 ℃ of surveys), and drying under reduced pressure is pulverized, and gets extract A;
B, with Cacumen Securinegae Suffruticosae, be ground into coarse powder, add for the first time 10 times of amount 70% ethanol, reflux, extract, 2 hours, second and third time adds 8 times of amount ethanol respectively, each extracted 2 hours, reclaimed ethanol to there not being the alcohol flavor, must receive pure cream, drying under reduced pressure is pulverized, extract B;
C, Ganoderma is earlier become the big fragment of 0.5～1cm with crusher in crushing, drop into rustless steel and extract in the pot, add the water of 14 times of Ganoderma weight.In the back-shaped pipe in the bottom of a pan, feed steam, make the water boiling and keep 2h, emit decocting liquid.Residue still stays in pot, adds the water of 12 times of amounts again, fries in shallow oil the same 2h of frying in shallow oil with first.Emit decocting liquid the 2nd time, 2 decocting liquids are merged, the input hopper, static 10h draws supernatant, discards the bottom land slurry.Again clear liquid is used earlier thin film concentration, concentrating under reduced pressure when than weigh 1: 1.36 (heat is surveyed), promptly gets the Ganoderma fluid extract again.
D, with extract A, B and Ganoderma fluid extract, technology is made corresponding dosage forms routinely.
When needs are prepared into solid preparation, with dry fine powder of extract and fluid extract, add corresponding adjuvant, make capsule, tablet or granule respectively according to the known conventional method of prior art.
Traditional Chinese compound medicine of the present invention can be used for the liver heat removing poison effectively, hepatoprotective reason spleen, transaminase lowering.Be applicable to acute and chronic hepatitis, chronic persistent hepatitis, early stage liver cirrhosis and hepatic disfunction.
Each Chinese medicine ingredients effect of the present invention is used as follows:
Cacumen Securinegae Suffruticosae (Herba Phyllanthi Urinariae): be the dry herb of Euphorbiaceae phyllanthus plant Cacumen Securinegae Suffruticosae Phyllanthus urinaria L..Has calming liver and clearing heat, the effect of promoting diuresis to remove toxic substance.Modern pharmacology experimental results show that Cacumen Securinegae Suffruticosae has anti-hepatitis virus (HBV), effect such as protects the liver, and is " anti-hepatitis virus research at present at most, most promising medicinal plants ", and compound recipe is better than single preparations of ephedrine.Effect and the interferon of compound recipe Cacumen Securinegae Suffruticosae removing serum HBeAg and HBV DNA are approaching.Herba Phyllanthi Urinariae can with the HBV-RNA specific bond, effectively suppress virus replication by the level that reduces hepatitis B virus duplication intermediate HBV-RNA.Pharmaceutical research shows that also Herba Phyllanthi Urinariae has significant protective effect to hepatocyte injury, also can effectively resist hepatocyte injury simultaneously.Primary hepatocarcinoma there is preventive effect.
Rhizoma Osmundae: HBsAg is had strong inhibitory action.
Fructus Schisandrae Chinensis: effect with the immunity adjusted, the liver protecting and ALT lowering.
Galla Chinensis: the effect of removing HBsAg is arranged, and research report is published in " Guangxi Medical University's journal "
Rhizoma Polygoni Cuspidati: Rhizoma Polygoni Cuspidati another name Radix Bauhihiae Championii, the therapeutical effect aspect hepatopathy: can effectively suppress multiple virus and various bacteria and infect, eliminate the liver inflammation, thereby slow down liver fibrosis process; The contained Polydatin tool blood fat reducing and the effect of hepatic cholagogic in the Rhizoma Polygoni Cuspidati; Can further suppress DHBV by human body immunity improving power.
Radix Isatidis: have heat-clearing and toxic substances removing, the effect of removing heat from blood sore-throat relieving.Card such as the pyretic toxicity of the treatment maculae caused by violent heat pathogen used of traditional medicine, mumps, sore throat, major part pestilence, erysipelas, carbuncle etc. since ancient times.Except the antibacterium virus function, Radix Isatidis also has antiendotoxin and anticancer effect, can form cell by enhancing antibody, regulates immunocompetence.For acute infectious hepatitis, Radix Isatidis granules also can play certain prevention and therapeutic efficiency,, it can promote the recovery of hepatocyte function.
Radix Salviae Miltiorrhizae: Radix Salviae Miltiorrhizae is a herbaceos perennial, and applicating history is long in China, and effect is very wide.Merit is arrogated to oneself blood circulation promoting and blood stasis dispelling.Along with pharmacological further investigation, Radix Salviae Miltiorrhizae mainly contains following several aspect to the therapeutical effect of liver: anti-hepatic fibrosis, improve liver function, to the protective effect of hepatic injury, promote liver cell regeneration, remove the hepatocyte oxygen-derived free radicals with, improve the liver cirrhosis portal hypertension, prevent and treat hepatoma Metastasis and recur.
Fructus Ligustri Lucidi: invigorating the liver and kidney effect.Modern pharmacological research has free radical, the enhancing immunity of removing, falls enzyme, blood sugar lowering, blood fat, hepatoprotective effect.
Ganoderma: Ganoderma is the treasure in the pools of traditional Chinese medicine, and is with a long history as medicinal application in China.Pharmacological research proves, Ganoderma has pharmacological action widely, as antitumor action, immunoregulation effect, anti-radiation and anti-chemotherapy effect, sedation, heart tonifying and function of resisting myocardial ischemia, blood lipid regulation effect, hypoglycemic activity, antiasthmatic effect, hepatoprotective effect, oxygen lack resistant function and anti-aging effects etc.Ganoderma is that the maximum of public hazards polluter is wished in the human body.
The Radix Astragali: the Radix Astragali can prevent that hepatic glycogen from reducing, and has protective effect to white mice carbon tetrachloride hepatitis.The Radix Astragali is turned out cloudy to the hepatitis B virus surface antigen positive also certain effect, compares significant difference (P＜0.05) with matched group.The clinical effective rate of treatment chronic hepatitis, liver-depression and spleen-insufficiency type and liver-kidney yin deficiency are respectively 92.1% and 88.5%, are excellent (P＜0.05) than matched group all.
The present invention selects pure Chinese medicine for use, and each component meets national pharmaceutical control law regulation, utilizes the comprehensive function of kinds of traditional Chinese medicines, and treatment hepatitis has no side effect to human body, and medicine is through by scientific process, and it is all convenient to carry, take.
In prescription of the present invention, be monarch drug with Herba Phyllanthi Urinariae, Rhizoma Polygoni Cuspidati in the side, heat-clearing and toxic substances removing, suppressing the hyperactive liver QI invigorating; Ministerial drug Radix Isatidis heat-clearing and toxic substances removing, Galla Chinensis is removed HBsAg, strengthens the merit of monarch drug Herba Phyllanthi Urinariae heat-clearing and toxic substances removing; The Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling helps the power of Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling; Radix Astragali hemostasis by invigorating QI; The Fructus Ligustri Lucidi liver and kidney tonifying; Fructus Schisandrae Chinensis is adjusted immunity, the liver protecting and ALT lowering; Ganoderma human body immunity improving power reaches the purpose of eliminating pathogenic factor for supporting vital QI.The ten flavor Chinese medicines effects of playing heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling altogether, " removing summer-heat and do not hinder healthy energy is invigorated blood circulation and removing blood stasis not " is we's characteristics.
The present invention also can by the prescription requirement, make the Chinese drugs agentia of any amount as required.Its production is easy, easily row.
The specific embodiment
The present invention is described further below in conjunction with embodiment:
Embodiment 1
According to prescription, get by weight: Rhizoma Polygoni Cuspidati 300g, Cacumen Securinegae Suffruticosae 300g, Rhizoma Osmundae 150g, Galla Chinensis 150g, Radix Isatidis 100g, Fructus Schisandrae Chinensis 100g, Fructus Ligustri Lucidi 100g, Radix Salviae Miltiorrhizae 100g, Ganoderma 120g, Radix Astragali 300g.
With Rhizoma Polygoni Cuspidati, Radix Isatidis, Radix Salviae Miltiorrhizae, the Radix Astragali, run through, cut sheet; The Rhizoma Osmundae remove impurity, chopping; Galla Chinensis, Fructus Schisandrae Chinensis, Fructus Ligustri Lucidi, remove impurity.With the medical material of handling well, add for the first time 8 times of water gagings and decocted 2 hours, add 6 times of water gagings respectively and decocted 1.5 hours for two, three times.Decoction liquor is concentrated into 1.25-1.30, and drying under reduced pressure is pulverized, and gets extract A; With Cacumen Securinegae Suffruticosae, be ground into coarse powder, add 10 times of amount 70% ethanol for the first time, reflux, extract, 2 hours, second and third time adds 8 times of amount ethanol respectively, and each extracted 2 hours, reclaimed ethanol and did not extremely have the alcohol flavor, must receive pure cream, and drying under reduced pressure is pulverized, and gets extract B; Ganoderma is become the big fragment of 0.5～1cm with crusher in crushing earlier, drop into rustless steel and extract in the pot, add the water of 14 times of Ganoderma weight.In the back-shaped pipe in the bottom of a pan, feed steam, make the water boiling and keep 2h, emit decocting liquid.Residue still stays in pot, adds the water of 12 times of amounts again, fries in shallow oil the same 2h of frying in shallow oil with first.Emit decocting liquid the 2nd time, 2 decocting liquids are merged, the input hopper, static 10h draws supernatant, discards the bottom land slurry.Again clear liquid is used earlier thin film concentration, concentrating under reduced pressure when than weigh 1: 1.36 (heat is surveyed), promptly gets the Ganoderma fluid extract again.
The soluble starch of 4 times of weight of adding own and extract A, B mix and stir in Ganoderma fluid extract (heat survey proportion about 1: 1.36), make electuary shape granule, and reuse tablet machine tabletting, sheet are added sugar-coat or film-coat outward again, oven dry, bottle.
Embodiment 2
According to prescription, get by weight: Rhizoma Polygoni Cuspidati 300g, Cacumen Securinegae Suffruticosae 300g, Rhizoma Osmundae 150g, Galla Chinensis 150g, Radix Isatidis 100g, Fructus Schisandrae Chinensis 100g, Fructus Ligustri Lucidi 100g, Radix Salviae Miltiorrhizae 100g, Ganoderma 120g, Radix Astragali 300g.
With Rhizoma Polygoni Cuspidati, Radix Isatidis, Radix Salviae Miltiorrhizae, the Radix Astragali, run through, cut sheet; The Rhizoma Osmundae remove impurity, chopping; Galla Chinensis, Fructus Schisandrae Chinensis, Fructus Ligustri Lucidi, remove impurity.With the medical material of handling well, add for the first time 10 times of water gagings and decocted 2 hours, add 8 times of water gagings respectively and decocted 1.5 hours for two, three times.Decoction liquor is concentrated into 1.20-1.30, and drying under reduced pressure is pulverized, and gets extract A; With Cacumen Securinegae Suffruticosae, be ground into coarse powder, add 10 times of amount 60% ethanol for the first time, reflux, extract, 2 hours, second and third time adds 8 times of amount ethanol respectively, and each extracted 2 hours, reclaimed ethanol and did not extremely have the alcohol flavor, must receive pure cream, and drying under reduced pressure is pulverized, and gets extract B; Ganoderma is become the big fragment of 0.5～1cm with crusher in crushing earlier, drop into rustless steel and extract in the pot, add the water of 10 times of Ganoderma weight.In the back-shaped pipe in the bottom of a pan, feed steam, make the water boiling and keep 2h, emit decocting liquid.Residue still stays in pot, adds the water of 8 times of amounts again, fries in shallow oil the same 2h of frying in shallow oil with first.Emit decocting liquid the 2nd time, 2 decocting liquids are merged, the input hopper, static 12h draws supernatant, discards the bottom land slurry.Again clear liquid is used earlier thin film concentration, concentrating under reduced pressure when than weigh 1: 1.25 (heat is surveyed), gets the Ganoderma fluid extract again.
The soluble starch of 3 times of weight of adding own and extract A, B mix and stir in Ganoderma fluid extract (heat survey proportion about 1: 1.25), make electuary shape granule, and reuse tablet machine tabletting, sheet are added sugar-coat or film-coat outward again, oven dry, bottle.
Embodiment 3
According to prescription, get by weight: Rhizoma Polygoni Cuspidati 250g, Cacumen Securinegae Suffruticosae 250g, Rhizoma Osmundae 120g, Galla Chinensis 120g, Radix Isatidis 150g, Fructus Schisandrae Chinensis 150g, Fructus Ligustri Lucidi 150g, Radix Salviae Miltiorrhizae 150g, Ganoderma 100g, Radix Astragali 250g.
With Rhizoma Polygoni Cuspidati, Radix Isatidis, Radix Salviae Miltiorrhizae, the Radix Astragali, run through, cut sheet; The Rhizoma Osmundae remove impurity, chopping; Galla Chinensis, Fructus Schisandrae Chinensis, Fructus Ligustri Lucidi, remove impurity.With the medical material of handling well, add for the first time 8 times of water gagings and decocted 2 hours, add 6 times of water gagings respectively and decocted 1.5 hours for two, three times.Decoction liquor is concentrated into 1.25-1.30, and drying under reduced pressure is pulverized, and gets extract A; With Cacumen Securinegae Suffruticosae, be ground into coarse powder, add 10 times of amount 70% ethanol for the first time, reflux, extract, 2 hours, second and third time adds 8 times of amount ethanol respectively, and each extracted 2 hours, reclaimed ethanol and did not extremely have the alcohol flavor, must receive pure cream, and drying under reduced pressure is pulverized, and gets extract B; Ganoderma is become the big fragment of 0.5～1cm with crusher in crushing earlier, drop into rustless steel and extract in the pot, add the water of 14 times of Ganoderma weight.In the back-shaped pipe in the bottom of a pan, feed steam, make the water boiling and keep 2h, emit decocting liquid.Residue still stays in pot, adds the water of 12 times of amounts again, fries in shallow oil the same 2h of frying in shallow oil with first.Emit decocting liquid the 2nd time, 2 decocting liquids are merged, the input hopper, static 10h draws supernatant, discards the bottom land slurry.Again clear liquid is used earlier thin film concentration, concentrating under reduced pressure when than weigh 1: 1.36 (heat is surveyed), promptly gets the Ganoderma fluid extract again.
The dextrin and the extract 1,2 of 3 times of weight of adding own mix and stir in Ganoderma extractum (heat survey proportion about 1: 1.36), and through the comminutor pelletize, oven dry packs (every packed 2g), promptly gets granule.
Embodiment 4
According to prescription, get by weight: Rhizoma Polygoni Cuspidati 120g, Cacumen Securinegae Suffruticosae 120g, Rhizoma Osmundae 100g, Galla Chinensis 100g, Radix Isatidis 80g, Fructus Schisandrae Chinensis 80g, Fructus Ligustri Lucidi 80g, Radix Salviae Miltiorrhizae 80g, Ganoderma 90g, Radix Astragali 120g.
With Rhizoma Polygoni Cuspidati, Radix Isatidis, Radix Salviae Miltiorrhizae, the Radix Astragali, run through, cut sheet; The Rhizoma Osmundae remove impurity, chopping; Galla Chinensis, Fructus Schisandrae Chinensis, Fructus Ligustri Lucidi, remove impurity.With the medical material of handling well, add for the first time 8 times of water gagings and decocted 2 hours, add 6 times of water gagings respectively and decocted 1.5 hours for two, three times.Decoction liquor is concentrated into 1.25-1.30, and drying under reduced pressure is pulverized, and gets extract A; With Cacumen Securinegae Suffruticosae, be ground into coarse powder, add 10 times of amount 70% ethanol for the first time, reflux, extract, 2 hours, second and third time adds 8 times of amount ethanol respectively, and each extracted 2 hours, reclaimed ethanol and did not extremely have the alcohol flavor, must receive pure cream, and drying under reduced pressure is pulverized, and gets extract B; Ganoderma is become the big fragment of 0.5～1cm with crusher in crushing earlier, drop into rustless steel and extract in the pot, add the water of 14 times of Ganoderma weight.In the back-shaped pipe in the bottom of a pan, feed steam, make the water boiling and keep 2h, emit decocting liquid.Residue still stays in pot, adds the water of 12 times of amounts again, fries in shallow oil the same 2h of frying in shallow oil with first.Emit decocting liquid the 2nd time, 2 decocting liquids are merged, the input hopper, static 10h draws supernatant, discards the bottom land slurry.Again clear liquid is used earlier thin film concentration, concentrating under reduced pressure when than weigh 1: 1.36 (heat is surveyed), promptly gets the Ganoderma fluid extract again.
The soluble starch and the extract 1,2 of the weight 50% of adding own mix and stir in Ganoderma fluid extract (heat is surveyed proportion about 1: 1.36), the decompression oven dry, and wearing into can be by the fine powder of No. 80 sieve meshes, encapsulated (every capsules dress 0.4g).
Embodiment 5
Rhizoma Polygoni Cuspidati 350g, Cacumen Securinegae Suffruticosae 350g, Rhizoma Osmundae 200g, Galla Chinensis 200g, Radix Isatidis 150g, Fructus Schisandrae Chinensis 120g, Fructus Ligustri Lucidi 120g, Radix Salviae Miltiorrhizae 120g, Ganoderma 150g, Radix Astragali 350g.
With Rhizoma Polygoni Cuspidati, Radix Isatidis, Radix Salviae Miltiorrhizae, the Radix Astragali, run through, cut sheet; The Rhizoma Osmundae remove impurity, chopping; Galla Chinensis, Fructus Schisandrae Chinensis, Fructus Ligustri Lucidi, remove impurity.With the medical material of handling well, add for the first time 8 times of water gagings and decocted 2 hours, add 6 times of water gagings respectively and decocted 1.5 hours for two, three times.Decoction liquor is concentrated into 1.25-1.30, and drying under reduced pressure is pulverized, and gets extract A; With Cacumen Securinegae Suffruticosae, be ground into coarse powder, add 10 times of amount 70% ethanol for the first time, reflux, extract, 2 hours, second and third time adds 8 times of amount ethanol respectively, and each extracted 2 hours, reclaimed ethanol and did not extremely have the alcohol flavor, must receive pure cream, and drying under reduced pressure is pulverized, and gets extract B; Ganoderma is become the big fragment of 0.5～1cm with crusher in crushing earlier, drop into rustless steel and extract in the pot, add the water of 14 times of Ganoderma weight.In the back-shaped pipe in the bottom of a pan, feed steam, make the water boiling and keep 2h, emit decocting liquid.Residue still stays in pot, adds the water of 12 times of amounts again, fries in shallow oil the same 2h of frying in shallow oil with first.Emit decocting liquid the 2nd time, 2 decocting liquids are merged, the input hopper, static 10h draws supernatant, discards the bottom land slurry.Again clear liquid is used earlier thin film concentration, concentrating under reduced pressure when than weigh 1: 1.36 (heat is surveyed), promptly gets the Ganoderma fluid extract again.
The soluble starch and the extract 1,2 of the weight 50% of adding own mix and stir in Ganoderma fluid extract (heat is surveyed proportion about 1: 1.36), the decompression oven dry, and wearing into can be by the fine powder of No. 80 sieve meshes, encapsulated (every capsules dress 0.6g).
The curative effect checking
From 2004 to 2006, with capsule clinical treatment 60 routine acute and chronic hepatitis, animal migration hepatitis, take half an hour after meal every day three times, take 3 months courses of treatment, symptom compares before and after treatment, the effect of having clear improvement.Carry out efficacy evaluation and curative effect statistics, cure rate is 76%, effective percentage 95%, inefficiency 5%;
Model case:
1, the schoolmarm of Zhengzhou City universities and colleges Xu * *, 33 years old now, in June, 2004, chronic active hepatitis was suffered from diagnosis, in May, 2004 promptly occurred inappetence, asthenia, abdominal distention, liver pain, find carrying out property hepatomegaly on inspection, liver function is obviously unusual, and phenomenon such as erythra often occurs.After adopting medicine medical treatment of the present invention in July, 2004, abdominal distention, liver pain transference cure.Appetite increases after January, and situations such as extremity asthenia disappear.After March, and two half inspections are all turned out cloudy, and follow-up investigation did not have any symptomatic recurrence in three months, came back on the work position.
2, cattle * *, man, 58 years old.Anyang, Henan Province Tiexi District people
Suffer from surplus the hepatitis B 20 year, occurred symptoms such as ascites, hematemesis, melena in nearly 5 years repeatedly.At local hospitalization repeatedly, heavy when light during the state of an illness.Patient's melena 3 days when seing patients in 2005, spiritual flaccidity gruel is become thin, ascites volume is many, and through taking Drug therapy of the present invention spirit in January amelioration, melena disappears.Body weight rising 5kg, ascites disappears.Adhere to obeying two months medicines, 1 year stable disease, do not have repeatedly.
3, the king * * man 67 years old retired cadre
Suffer from hepatopathy before 9 years accidentally, often felt epigastric discomfort, dull pain in liver, malaise, food is received not fragrant, listless, anxiously, many experts that sought medical advice have spent tens thousand of first expensess for medicine, also fail to cure, back Drug therapy of the present invention is taken medicine and is just got well substantially less than two months, after consolidated again one month, now fully recover, so far not recurrence.
4, poplar *, the workman of Henan factory of 26 years old caught sight of weakly before 2 years, anorexia is detested oil, symptom such as feel sick, it is muddy that the urine color also adds gradually, heating, companion's tenderness.After be diagnosed as acute icterohepatitisshock, method such as combination treatment half a year in the employing, nothing is clearly better, and adopts Drug therapy of the present invention, through the treatment of a course of treatment, the heating phenomenon of feeling sick disappears, urine sample also is normally, and after three months, the hepatic region tenderness disappears, the liver spleen is contracted to normal range on inspection, and liver function recovery is normal.
Claims (2)
1. Chinese medicine compound compositions for the treatment of hepatitis, it is characterized in that: its ingredient weight proportion is as follows:
300 parts of Rhizoma Polygoni Cuspidati, 300 parts of Cacumen Securinegae Suffruticosaes, 150 parts of Rhizoma Osmundae, 150 parts of Galla Chinensiss, 100 parts of Radix Isatidis, 100 parts of Fructus Schisandrae Chinensis, 100 parts of Fructus Ligustri Lucidi, 100 parts of Radix Salviae Miltiorrhizaes, 120 parts of Ganodermas, 300 parts of the Radixs Astragali.
2. the Chinese medicine compound compositions of treatment hepatitis according to claim 1 is characterized in that: the dosage form of described Chinese medicine compound compositions is any one in granule, tablet, the capsule.
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| CN2007100538194A CN101011470B (en) | 2007-01-09 | 2007-01-09 | Traditional Chinese medicine compound composition for treating hepatitis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101375951B (en) * | 2007-08-29 | 2012-03-07 | 北京星昊嘉宇医药科技有限公司 | Medicine composition for treating hepatitis B |
| CN102973660B (en) * | 2011-09-06 | 2014-10-15 | 江中药业股份有限公司 | Chronic hepatitis treatment traditional Chinese medicine composition and preparation method thereof |
| CN105985930B (en) * | 2016-06-15 | 2019-12-13 | 辛普森国际生命科技(天津)有限公司 | Mesenchymal stem cell combined with traditional Chinese medicine activation and amplification and preparation method and application thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1273852A (en) * | 1999-05-18 | 2000-11-22 | 卢中燕 | Chinese medicine for curing chronic hepatitis B |
| CN1321480A (en) * | 2000-04-29 | 2001-11-14 | 尹耀成 | Chinese medicine decoction for curing hepatitis B |
| CN1371726A (en) * | 2002-03-20 | 2002-10-02 | 黄资源 | Decocted pill medicine for treating excess syndrome of hepatitis B |
| CN1375325A (en) * | 2002-03-27 | 2002-10-23 | 李少华 | Composite medicine for treating hepatitis B |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1273852A (en) * | 1999-05-18 | 2000-11-22 | 卢中燕 | Chinese medicine for curing chronic hepatitis B |
| CN1321480A (en) * | 2000-04-29 | 2001-11-14 | 尹耀成 | Chinese medicine decoction for curing hepatitis B |
| CN1371726A (en) * | 2002-03-20 | 2002-10-02 | 黄资源 | Decocted pill medicine for treating excess syndrome of hepatitis B |
| CN1375325A (en) * | 2002-03-27 | 2002-10-23 | 李少华 | Composite medicine for treating hepatitis B |
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