CN105670857A - Preparation method of cholesterol-lowering Lentinula edodes unstrained wine - Google Patents

Abstract

The invention discloses a preparation method of a cholesterol-lowering Lentinula edodes unstrained wine.The preparation method includes subjecting main materials including Lentinula edodes, glutinous rice, broomcorn millet, sorghum, sweet potatoes, millet and potatoes to pretreatment, heat leaching, enzymolysis, stir-frying, stewing for gelatinization, diastatic fermentation, squeezing filtration, ageing, composition adjustment, homogenizing, bottling, sterilization and the like.The cholesterol-lowering Lentinula edodes unstrained wine in caramel color is strong in sauce aroma, stick-slip and soft in taste, rich in nutrition, moderate in alcohol content, capable of balancing cholesterol content in human body blood and lowering arteriosclerosis probability and suitable for the elderly and females to drink.

Description

A kind of preparation method of the Lentinus Edodes unstrained liquor for cholesterol reducing

Technical field

The preparation method that the present invention relates to a kind of Lentinus Edodes unstrained liquor for cholesterol reducing.

Background technology

Coronary heart disease is the main cause of current deaths from heart disease, and cerebrovascular disease is also able to cause the important diseases of death, and the cause of disease of both diseases is exactly arteriosclerosis. Clinical manifestation according to arteriosclerosis, it is the main cause of annual more than 100 ten thousand heart and brain onstes and about 400000 apoplexy persons. Except the high incidence and high mortality of arteriosclerosis, a large amount of evidences have been proven that the cause effect relation between hypercholesterolemia and too early arteriosclerosis, and blood plasma cholesterol level is more high, and the danger of heart attack is more big. At present, to the treatment of reduction cholesterol mainly just like Statins (based on cholesterol reducing, it represents medicine has: simvastatin, Provastain etc.) and fibrates (based on triglyceride reducing, it represents medicine has: gemfibrozil, fenofibrate capsules etc.); The feature of Western medicine is instant effect, but side effect is very big, take for a long time and liver can be caused damage, it it is the principal element of iatrogenic hepatic injury, add up according to World Health Organization (WHO) (WTO), account for the 10% of whole inpatient from the iatrogenic hepatic injury of medicine at present, bring bigger misery to patient.

Summary of the invention

In view of above-mentioned the deficiencies in the prior art, the preparation method of a kind of Lentinus Edodes unstrained liquor for cholesterol reducing that it is an object of the invention to provide.

For solving above-mentioned technical problem, the present invention program includes:

A kind of preparation method of the Lentinus Edodes unstrained liquor for cholesterol reducing, it comprises the following steps:

Step one, pretreatment: Lentinus Edodes is cleaned and shreds; Oryza glutinosa, Semen Panici miliacei, Sorghum vulgare Pers., Semen setariae are cleaned, cold water soak 5 hours; Fresh Radix Pachyrhizi Erosi, peeling potatoes are diced; Lentinus Edodes: Oryza glutinosa: Semen Panici miliacei: Sorghum vulgare Pers.: Semen setariae: Radix Pachyrhizi Erosi: the mass ratio of Rhizoma Solani tuber osi is: 1:5:5:1:1:1:1;

Step 2, hot dipping carries: Fructus Jujubae 10-15 part, Fructus Lycii 10-15 part, Radix Angelicae Sinensis 10-15 part, Rhizoma Dioscoreae 5-10 part, Radix Codonopsis 10-15 part, Fructus Amomi 1-2 part, Semen Myristicae 1-3 part, Cortex Cinnamomi 1-2 part, Flos Caryophylli 1-2 part, Radix Aucklandiae 1-2 part, Radix Angelicae Dahuricae 1-2 part, Rhizoma Kaempferiae 1-5 part are ground with Rhizoma Zingiberis 10-15 part, it is placed in hot water lixiviate 1 hour, obtains extracting solution;

Step 3, enzymolysis: Gallus Domesticus muscle is cut and mixes meat paste, addition trypsin is hydrolyzed and prepares Gallus Domesticus enzymolysis solution, and the addition of enzyme is 5000U/kg, and enzymolysis pH is 8.0, and temperature is 37 DEG C;

Step 4, parch: be placed in pot by Semen Panici miliacei in step one, Sorghum vulgare Pers., Semen setariae mixing parch, to being charred fragrance release, obtain coking material;

Step 5, steaming and decocting gelatinizing: the Oryza glutinosa in step one, Lentinus Edodes, Radix Pachyrhizi Erosi, Rhizoma Solani tuber osi mix homogeneously are placed in pot and steam 20 minutes, extremely to the grain of rice without hard-core, form mixing glutinous rice, then mixing glutinous rice is immersed in the Gallus Domesticus enzymolysis solution that step 3 obtains, soak 24 hours, obtain Oryza glutinosa material;

Step 6, diastatic fermentation: be naturally cooling to 40 DEG C after the Oryza glutinosa material of the coking material of step 4 and step 5 is mixed into pureed, then the extracting solution that α-amylase, saccharifying enzyme, distillers yeast and step 2 obtain it is added thereto to, it is placed in ferment at constant temperature tank and ferments 25 days, within first 5 days, temperature controls at 25-30 DEG C, and latter temperature controls at 15-18 DEG C;

Step 7, squeeze and filter: apply squeezer after fermentation ends and squeeze, remove schlempe, obtain wine base.

Described preparation method, wherein, also includes after above-mentioned steps seven:

Step 8, obtains aging wine in the fermentation tank of airtight 10-15 of depositing in DEG C of step 7 gained wine base or Porcelain Jar;

Step 9, adds soybean oligo saccharide, lactic acid to the aging wine liquid of step 8 gained and carries out composition adjustment, adjusts sugar to 40g/L, total acid to 5g/L; Add xanthan gum, sodium carboxymethyl cellulose stablizes wine body, and wherein the addition of xanthan gum is about 0.05%-0.1%, sodium carboxymethyl cellulose 0.08%-0.12%; Obtain above-mentioned Lentinus Edodes unstrained liquor

Step 10, is preheated to 50～60 DEG C by the Lentinus Edodes unstrained liquor in step 9, pumps into homogenizer, and homogenization pressure is 10～25MPa, after then being bottled by wine liquid, carries out pasteurize.

The preparation method of a kind of Lentinus Edodes unstrained liquor for cholesterol reducing provided by the invention, Lentinus Edodes is a kind of edible fungus, delicious flavour, fragrance oozes people, rich in vitamin B group, ferrum, potassium, provitamin D and lentinan, immune function of human body, appetite stimulator can be improved, human body is had the effects such as anticancer, blood fat reducing, intestine moistening stomach and beauty treatment; Fructus Lycii nourishing the liver and kidney, replenishing vital essence to improve eyesight. Containing 14 seed amino acids in Fructus Lycii, and containing special dietary compositions such as glycine betaine, beautiful another name for Sichuan Province flavin, physalins so that it is having outstanding health-care effect, for asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand; Chinese angelica blood supplementing is invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation, it is possible to well along logical inside of human body, in blood deficiency and yellow complexion, dizziness cardiopalmus, menoxenia, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores; Radix Codonopsis QI invigorating hold concurrently can nourish blood, should be used for usually fatigue and weakness, lassitude. Voice is overcast, conscious breathes hard, the slightly movable insufficiency of lung-QI weak person with regard to dyspnea with rapid and short breath. Lay particular emphasis on the people of deficiency of spleen-QI and stomach-QI, myasthenia of limbs, inappetence, loose stool; Semen Myristicae, containing volatile oil, can promote secretion and the gastrointestinal peristalsis of gastric juice on a small quantity, and has appetizing and promote appetite, effect of relieving distension pain relieving; Fructus Jujubae is holy product of enriching blood, invigorating QI and tranquilization, has blood circulation promoting and enriching, skin care, granulation promoting to enrich blood, the effect such as menstruction regulating and pain relieving, loosening bowel to relieve constipation, human metabolism and endocrine function can be strengthened, preventing and treating face is dry, makes skin gloss delicate, women's delay senility is had certain dietotherapy effect; Gallus Domesticus is nourishing and the nourishing food of women and old man, include abundant melanin, protein, vitamin B group etc. 18 seed amino acid and 18 kinds of trace element, wherein nicotinic acid, vitamin E, phosphorus, ferrum, potassium, sodium content be above common Carnis Gallus domesticus, cholesterol and fat content but very, have qi-restoratives labor thin and weak, and system is quenched one's thirst and improved physiological function, slow down aging, strengthening the tendons and bones; Soybean oligo saccharide has the effect of regulating gastointestinal, relieving constipation.

Clinical data:

For showing the therapeutic effect of medicine of the present invention, the present invention carries out the clinical research of system through 200 example hypercholesterolemia patients, and 200 example cases derive from development zone in Qingdao hospital.

Treatment group: choose 100 examples by random method, uses Lentinus Edodes unstrained liquor of the present invention 4 weeks.

Matched group: choose 100 examples by random method, uses Provastain to treat 4 weeks.

Two groups in the state of an illness, sex, age, the course of disease etc. through statistical procedures no significant difference.

Instructions of taking: treatment group: drink Lentinus Edodes unstrained liquor every day about 100g/ time, one day 2 times, treats 4 weeks. Matched group: once a day, once takes Provastain 20mg, treats 4 weeks.

Observation index and method

Standard with reference to " new Chinese medicine guideline of clinical investigations ".

Treatment group, controls between 2.4--4.5mmol/L all the time by blood inner cholesterol, cures 85 examples, effective 15 examples, invalid 0 example, total effective rate 100%. Matched group, cures 70 examples, effective 20 examples, invalid 10 examples, total effective rate 80%, but makes blood inner cholesterol changes of contents too fast over the course for the treatment of, bring many miseries to patient. Between two groups, difference has very significant, and treatment group is substantially better than matched group.

Accompanying drawing explanation

Fig. 1 is the schematic flow sheet of preparation method in the present invention.

Detailed description of the invention

The preparation method that the invention provides a kind of Lentinus Edodes unstrained liquor for cholesterol reducing, for making the purpose of the present invention, technical scheme and effect clearly, clearly, the present invention is described in more detail below. Should be appreciated that specific embodiment described herein is only in order to explain the present invention, is not intended to limit the present invention.

The preparation method that the invention provides a kind of Lentinus Edodes unstrained liquor for cholesterol reducing, it comprises the following steps:

Step one, pretreatment: Lentinus Edodes is cleaned and shreds; Oryza glutinosa, Semen Panici miliacei, Sorghum vulgare Pers., Semen setariae are cleaned, cold water soak 5 hours; Fresh Radix Pachyrhizi Erosi, peeling potatoes are diced; Lentinus Edodes: Oryza glutinosa: Semen Panici miliacei: Sorghum vulgare Pers.: Semen setariae: Radix Pachyrhizi Erosi: the mass ratio of Rhizoma Solani tuber osi is: 1:5:5:1:1:1:1;

Step 2, hot dipping carries: Fructus Jujubae 10-15 part, Fructus Lycii 10-15 part, Radix Angelicae Sinensis 10-15 part, Rhizoma Dioscoreae 5-10 part, Radix Codonopsis 10-15 part, Fructus Amomi 1-2 part, Semen Myristicae 1-3 part, Cortex Cinnamomi 1-2 part, Flos Caryophylli 1-2 part, Radix Aucklandiae 1-2 part, Radix Angelicae Dahuricae 1-2 part, Rhizoma Kaempferiae 1-5 part are ground with Rhizoma Zingiberis 10-15 part, it is placed in hot water lixiviate 1 hour, obtains extracting solution;

Step 3, enzymolysis: Gallus Domesticus muscle is cut and mixes meat paste, addition trypsin is hydrolyzed and prepares Gallus Domesticus enzymolysis solution, and the addition of enzyme is 5000U/kg, and enzymolysis pH is 8.0, and temperature is 37 DEG C;

Step 4, parch: be placed in pot by Semen Panici miliacei in step one, Sorghum vulgare Pers., Semen setariae mixing parch, to being charred fragrance release, obtain coking material;

Step 5, steaming and decocting gelatinizing: the Oryza glutinosa in step one, Lentinus Edodes, Radix Pachyrhizi Erosi, Rhizoma Solani tuber osi mix homogeneously are placed in pot and steam 20 minutes, extremely to the grain of rice without hard-core, form mixing glutinous rice, then mixing glutinous rice is immersed in the Gallus Domesticus enzymolysis solution that step 3 obtains, soak 24 hours, obtain Oryza glutinosa material;

Step 6, diastatic fermentation: be naturally cooling to 40 DEG C after the Oryza glutinosa material of the coking material of step 4 and step 5 is mixed into pureed, then the extracting solution that α-amylase, saccharifying enzyme, distillers yeast and step 2 obtain it is added thereto to, it is placed in ferment at constant temperature tank and ferments 25 days, within first 5 days, temperature controls at 25-30 DEG C, and latter temperature controls at 15-18 DEG C;

Step 7, squeeze and filter: apply squeezer after fermentation ends and squeeze, remove schlempe, obtain wine base.

And also include after above-mentioned steps seven:

Step 8, obtains aging wine in the fermentation tank of airtight 10-15 of depositing in DEG C of step 7 gained wine base or Porcelain Jar;

Step 9, adds soybean oligo saccharide, lactic acid to the aging wine liquid of step 8 gained and carries out composition adjustment, adjusts sugar to 40g/L, total acid to 5g/L; Add xanthan gum, sodium carboxymethyl cellulose stablizes wine body, and wherein the addition of xanthan gum is about 0.05%-0.1%, sodium carboxymethyl cellulose 0.08%-0.12%; Obtain above-mentioned Lentinus Edodes unstrained liquor

Step 10, is preheated to 50～60 DEG C by the Lentinus Edodes unstrained liquor in step 9, pumps into homogenizer, and homogenization pressure is 10～25MPa, after then being bottled by wine liquid, carries out pasteurize.

In order to be further described the present invention, it is exemplified below more detailed embodiment and illustrates.

Select fresh Lentinus Edodes, cleaned and shred into fourth or sheet, weigh 10kg; Oryza glutinosa 50kg, Semen Panici miliacei 50kg, Sorghum vulgare Pers. 10kg, Semen setariae are cleaned 10kg and be placed in cold water and soak 5 hours; Fresh Radix Pachyrhizi Erosi 10kg, Rhizoma Solani tuber osi 10kg peeling is diced; 1.5kg Fructus Jujubae, 1.5kg Fructus Lycii, Radix Angelicae Sinensis 1kg, Rhizoma Zingiberis 1kg, Radix Codonopsis 1kg, Rhizoma Dioscoreae 0.5kg, Semen Myristicae 0.1kg, Fructus Amomi 0.1kg, Cortex Cinnamomi 0.1kg, Flos Caryophylli 0.1kg, Radix Aucklandiae 0.1kg, Radix Angelicae Dahuricae 0.1kg, Rhizoma Kaempferiae 0.5kg mix homogeneously are ground, it is placed in hot water and boils the lixiviating solution preparing spice, hot dipping carries 0.5 hour, and the water yield is than for 36kg; Being cut by 2kg Gallus Domesticus muscle and mix meat paste, add trypsin 100000U and be hydrolyzed, prepare Gallus Domesticus enzymolysis solution, enzymolysis pH is 8.0, and temperature is 37 DEG C; Semen Panici miliacei, Sorghum vulgare Pers., Semen setariae mixing are placed in pot parch, to being charred fragrance release; By Oryza glutinosa, Lentinus Edodes, Radix Pachyrhizi Erosi, Rhizoma Solani tuber osi mix homogeneously be placed in pot and steam 20 minutes, to the grain of rice without hard-core, form mixing glutinous rice; The Oryza glutinosa of process, Semen Panici miliacei, Sorghum vulgare Pers., Semen setariae are naturally cooling to 40 DEG C after being mixed into pureed, add 5kg α-amylase, 5kg saccharifying enzyme, 10kg distillers yeast, being placed in ferment at constant temperature tank and ferment 25 days, within first 5 days, temperature controls at 25-30 DEG C, and latter temperature controls at 15-18 DEG C; Apply squeezer after fermentation ends to squeeze, remove schlempe, retain wine liquid; To squeeze aging in the airtight fermentation tank depositing in 10-15 DEG C of wine liquid or Porcelain Jar, and add soybean oligo saccharide 1kg, lactic acid 0.5kg carries out composition adjustment; Adding xanthan gum 0.1kg, sodium carboxymethyl cellulose 0.2kg and stablize wine body, the lixiviating solution 35L adding spice carries out perfumery; Add Gallus Domesticus enzymolysis solution 1L; Wine liquid being preheated to 50～60 DEG C, pumps into homogenizer, homogenization pressure is 10～25MPa; After being bottled by wine liquid, carry out pasteurize.

Gained Lentinus Edodes unstrained liquor is burnt sugar coloring, and wine liquid is stable, entrance, joyful mellow no suspended substance sense, micro-has Lentinus Edodes fragrance, has and have typical burnt odor and sweet-smelling, with moderate sweet taste, it is possible to balanced human's blood inner cholesterol content. This invention distillation yield is 175%, and alcoholic strength is 11.5%, and residual sugar content is 40g/L, and total acid is 6.78g/L; Containing 21 seed amino acids, its Glutamic Acid, leucine, alanine content are the highest; Total amino acids content is 3.86g/L, and total phenol content is 0.22g/L, and pH value is 4.23.

Certainly; described above it is only presently preferred embodiments of the present invention; the present invention is not limited to enumerate above-described embodiment; should be noted that; any those of ordinary skill in the art are under the instruction of this specification; made all equivalent replacement, obvious variant, all fall within the essential scope of this specification, ought to be subject to the protection of the present invention.

Claims (2)

1., for a preparation method for the Lentinus Edodes unstrained liquor of cholesterol reducing, it comprises the following steps:

Step one, pretreatment: Lentinus Edodes is cleaned and shreds; Oryza glutinosa, Semen Panici miliacei, Sorghum vulgare Pers., Semen setariae are cleaned, cold water soak 5 hours; Fresh Radix Pachyrhizi Erosi, peeling potatoes are diced; Lentinus Edodes: Oryza glutinosa: Semen Panici miliacei: Sorghum vulgare Pers.: Semen setariae: Radix Pachyrhizi Erosi: the mass ratio of Rhizoma Solani tuber osi is: 1:5:5:1:1:1:1;

Step 2, hot dipping carries: Fructus Jujubae 10-15 part, Fructus Lycii 10-15 part, Radix Angelicae Sinensis 10-15 part, Rhizoma Dioscoreae 5-10 part, Radix Codonopsis 10-15 part, Fructus Amomi 1-2 part, Semen Myristicae 1-3 part, Cortex Cinnamomi 1-2 part, Flos Caryophylli 1-2 part, Radix Aucklandiae 1-2 part, Radix Angelicae Dahuricae 1-2 part, Rhizoma Kaempferiae 1-5 part are ground with Rhizoma Zingiberis 10-15 part, it is placed in hot water lixiviate 1 hour, obtains extracting solution;

Step 3, enzymolysis: Gallus Domesticus muscle is cut and mixes meat paste, addition trypsin is hydrolyzed and prepares Gallus Domesticus enzymolysis solution, and the addition of enzyme is 5000U/kg, and enzymolysis pH is 8.0, and temperature is 37 DEG C;

Step 4, parch: be placed in pot by Semen Panici miliacei in step one, Sorghum vulgare Pers., Semen setariae mixing parch, to being charred fragrance release, obtain coking material;

Step 5, steaming and decocting gelatinizing: the Oryza glutinosa in step one, Lentinus Edodes, Radix Pachyrhizi Erosi, Rhizoma Solani tuber osi mix homogeneously are placed in pot and steam 20 minutes, extremely to the grain of rice without hard-core, form mixing glutinous rice, then mixing glutinous rice is immersed in the Gallus Domesticus enzymolysis solution that step 3 obtains, soak 24 hours, obtain Oryza glutinosa material;

Step 6, diastatic fermentation: be naturally cooling to 40 DEG C after the Oryza glutinosa material of the coking material of step 4 and step 5 is mixed into pureed, then the extracting solution that α-amylase, saccharifying enzyme, distillers yeast and step 2 obtain it is added thereto to, it is placed in ferment at constant temperature tank and ferments 25 days, within first 5 days, temperature controls at 25-30 DEG C, and latter temperature controls at 15-18 DEG C;

Step 7, squeeze and filter: apply squeezer after fermentation ends and squeeze, remove schlempe, obtain wine base.

2. preparation method according to claim 1, it is characterised in that also include after above-mentioned steps seven:

Step 8, obtains aging wine in the fermentation tank of airtight 10-15 of depositing in DEG C of step 7 gained wine base or Porcelain Jar;

Step 9, adds soybean oligo saccharide, lactic acid to the aging wine liquid of step 8 gained and carries out composition adjustment, adjusts sugar to 40g/L, total acid to 5g/L; Add xanthan gum, sodium carboxymethyl cellulose stablizes wine body, and wherein the addition of xanthan gum is about 0.05%-0.1%, sodium carboxymethyl cellulose 0.08%-0.12%; Obtain above-mentioned Lentinus Edodes unstrained liquor

Step 10, is preheated to 50～60 DEG C by the Lentinus Edodes unstrained liquor in step 9, pumps into homogenizer, and homogenization pressure is 10～25MPa, after then being bottled by wine liquid, carries out pasteurize.