CN105664047A - Traditional Chinese medicine preparation for treating esophageal squamous carcinoma - Google Patents

Traditional Chinese medicine preparation for treating esophageal squamous carcinoma Download PDF

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CN105664047A
CN105664047A CN201610124694.9A CN201610124694A CN105664047A CN 105664047 A CN105664047 A CN 105664047A CN 201610124694 A CN201610124694 A CN 201610124694A CN 105664047 A CN105664047 A CN 105664047A
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chinese medicine
medicine preparation
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杨菲斐
赵海波
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Abstract

The invention discloses a traditional Chinese medicine preparation for treating esophageal squamous carcinoma. The preparation is prepared from the following medicinal raw materials: semen raphani, agarwood, amomum tsao-ko, fructus amomi rotundus, pericarpium citri reticulatae viride, ligusticum wallichii, radix isatidis, clematis chinensis, agrimonia pilosa ledeb, roasted dried lacquer, peppermint, radix curcuma, rhizoma atractylodis macrocephalae, lindera aggregata, rhizoma belamcandae, chrysanthemum, radix ophiopogonis, radix codonopsis, cistanche deserticola, anemarrhenae, alga, radix cureumae, licorice root and realgar. The traditional Chinese medicine preparation focuses on pathogenesis to treat both symptoms and root causes, has the effects of removing toxicity, eliminating phlegm, nourishing yin, promoting production of body fluid, clearing heat, eliminating stagnation, promoting blood circulation to remove stasis, resolving hardness and breaking stagnation, does not hurt normal cells while cancer cells are inhibited and killed, has the functions of eliminating pathogens, strengthening body resistance and the like, can be used for effectively prolonging lives of esophageal squamous carcinoma patients and well improving the living quality, and is worthy of clinical popularization and application.

Description

A kind of Chinese medicine preparation treating esophageal squamous cell carcinoma
Technical field
The invention belongs to the field of Chinese medicines, specifically a kind of Chinese medicine preparation that can treat esophageal squamous cell carcinoma.
Background technology
Esophageal squamous cell carcinoma esophageal squamous cell carcinoma is the malignant tumour occurring in epithelium of esophagus tissue, accounts for the 2% of all malignant tumours. The whole world about has 220,000 people to die from esophageal squamous cell carcinoma every year, and China is esophageal squamous cell carcinoma district occurred frequently, occupies the 2nd because esophageal squamous cell carcinoma mortality ratio is only second to cancer of the stomach, and age of onset is many more than 40 years old, and the male sex is more than women, but within less than 40 years old in recent years, sends out patient and have rising tendency. The generation of esophageal squamous cell carcinoma is relevant with the absorption of smoking, excessive consumption of alcohol, nitrosamine chronic stimulation, chronic non-controllability inflammation and persistence wound, inherited genetic factors and vegetable and fruit.
At present, western medical treatment esophageal squamous cell carcinoma mainly adopts operation, radiotherapy and chemotherapy mode to carry out. Operation is that one has wound treatment, the immunity function decline of postoperative patient health, and explosive growth and distant metastasis easily occur esophageal cancer cell remaining after causing art; And chemotherapy mainly utilizes chemotherapeutic to suppress for the division growth of cancer cell, owing to some cancer cells is similar in certain period and normal cell, it is in quiescent condition, chemotherapeutics just can not play lethal effect, cause conditions of patients repeatedly, treatment is difficult to thoroughly, and human body side effect is big.
Still could not breaking away from the shade of cancer after experienced by the western medical treatments such as operation, chemicotherapy, more and more esophageal squamous cell carcinoma patient gradually starts to seek help from Chinese traditional treatment. Therefore the present invention debates, according to the traditional Chinese medical science, the principle that disease treats, treats both principal and secondary aspect of disease, provide a kind of alleviation and treating primary cause to combine, treat local and whole body nurses one's health the pure Chinese medicinal preparation that combines, substantially increase the life quality of esophageal squamous cell carcinoma patient, and extend life, it is to increase survival rate.
Summary of the invention
Instant invention overcomes the technical deficiency that current doctor trained in Western medicine exists in treatment esophageal squamous cell carcinoma, it provides a kind of can effectively alleviate patient suffering, improve patients ' life quality, extend patient's life and even thoroughly cure the Chinese medicine preparation of trouble.
The technical solution adopted in the present invention is: a kind of Chinese medicine preparation treating esophageal squamous cell carcinoma, it is characterised in that, described Chinese medicine preparation is made up of the Chinese herb of following weight part:
Semen Raphani 10-20 gram, agalloch eaglewood 10-20 gram, tsaoko 10-20 gram, 10-20 gram, cardamom, 10-20 gram, rascal, Ligusticum wallichii 10-20 gram, Root of Indigowoad 10-20 gram, 10-20 gram, Root of Sixpetal Clematis, Herba Agrimoniae 10-20 gram, 5-8 gram, fried dry paint, peppermint 5-8 gram, 10-15 gram, turmeric, bighead atractylodes rhizome 5-8 gram, root of three-nerved spicebush 5-8 gram, blackberry lily 10-15 gram, chrysanthemum 5-8 gram, tuber of dwarf lilyturf 5-8 gram, Radix Codonopsis 10-20 gram, desert cistanche 10-20 gram, wind-weed 5-8 gram, marine alga 5-15 gram, root tuber of aromatic turmeric 5-10 gram, 10-20 gram, Radix Glycyrrhizae, realgar 5-8 gram.
As a kind of prioritization scheme:
Described Chinese medicine preparation is made up of the Chinese herb of following weight part:
Semen Raphani 10 grams, agalloch eaglewood 10 grams, tsaoko 10 grams, 10 grams, cardamom, 10 grams, rascal, Ligusticum wallichii 10 grams, Root of Indigowoad 10 grams, 10 grams, Root of Sixpetal Clematis, Herba Agrimoniae 10 grams, 5 grams, fried dry paint, peppermint 5 grams, 10 grams, turmeric, the bighead atractylodes rhizome 5 grams, the root of three-nerved spicebush 5 grams, blackberry lily 10 grams, chrysanthemum 5 grams, the tuber of dwarf lilyturf 5 grams, Radix Codonopsis 10 grams, desert cistanche 10 grams, the wind-weed 5 grams, marine alga 5 grams, root tuber of aromatic turmeric 5 grams, 10 grams, Radix Glycyrrhizae, realgar 5 grams.
As a kind of prioritization scheme:
Described Chinese medicine preparation is made up of the Chinese herb of following weight part:
Semen Raphani 12 grams, agalloch eaglewood 12 grams, tsaoko 12 grams, 12 grams, cardamom, 12 grams, rascal, Ligusticum wallichii 12 grams, Root of Indigowoad 12 grams, 12 grams, Root of Sixpetal Clematis, Herba Agrimoniae 12 grams, 5 grams, fried dry paint, peppermint 6 grams, 11 grams, turmeric, the bighead atractylodes rhizome 5 grams, the root of three-nerved spicebush 6 grams, blackberry lily 11 grams, chrysanthemum 6 grams, the tuber of dwarf lilyturf 5 grams, Radix Codonopsis 12 grams, desert cistanche 12 grams, the wind-weed 5 grams, marine alga 7 grams, root tuber of aromatic turmeric 6 grams, 12 grams, Radix Glycyrrhizae, realgar 6 grams.
As a kind of prioritization scheme:
Described Chinese medicine preparation is made up of the Chinese herb of following weight part:
Semen Raphani 14 grams, agalloch eaglewood 14 grams, tsaoko 14 grams, 14 grams, cardamom, 14 grams, rascal, Ligusticum wallichii 14 grams, Root of Indigowoad 14 grams, 14 grams, Root of Sixpetal Clematis, Herba Agrimoniae 14 grams, 6 grams, fried dry paint, peppermint 6 grams, 12 grams, turmeric, the bighead atractylodes rhizome 6 grams, the root of three-nerved spicebush 6 grams, blackberry lily 12 grams, chrysanthemum 6 grams, the tuber of dwarf lilyturf 6 grams, Radix Codonopsis 14 grams, desert cistanche 14 grams, the wind-weed 6 grams, marine alga 9 grams, root tuber of aromatic turmeric 7 grams, 14 grams, Radix Glycyrrhizae, realgar 6 grams.
As a kind of prioritization scheme:
Described Chinese medicine preparation is made up of the Chinese herb of following weight part:
Semen Raphani 16 grams, agalloch eaglewood 16 grams, tsaoko 16 grams, 16 grams, cardamom, 16 grams, rascal, Ligusticum wallichii 16 grams, Root of Indigowoad 16 grams, 16 grams, Root of Sixpetal Clematis, Herba Agrimoniae 16 grams, 6 grams, fried dry paint, peppermint 7 grams, 13 grams, turmeric, the bighead atractylodes rhizome 6 grams, the root of three-nerved spicebush 7 grams, blackberry lily 13 grams, chrysanthemum 6 grams, the tuber of dwarf lilyturf 7 grams, Radix Codonopsis 16 grams, desert cistanche 16 grams, the wind-weed 6 grams, marine alga 11 grams, root tuber of aromatic turmeric 8 grams, 16 grams, Radix Glycyrrhizae, realgar 7 grams.
As a kind of prioritization scheme:
Described Chinese medicine preparation is made up of the Chinese herb of following weight part:
Semen Raphani 18 grams, agalloch eaglewood 18 grams, tsaoko 18 grams, 18 grams, cardamom, 18 grams, rascal, Ligusticum wallichii 18 grams, Root of Indigowoad 18 grams, 18 grams, Root of Sixpetal Clematis, Herba Agrimoniae 18 grams, 7 grams, fried dry paint, peppermint 7 grams, 14 grams, turmeric, the bighead atractylodes rhizome 7 grams, the root of three-nerved spicebush 7 grams, blackberry lily 14 grams, chrysanthemum 7 grams, the tuber of dwarf lilyturf 7 grams, Radix Codonopsis 18 grams, desert cistanche 18 grams, the wind-weed 7 grams, marine alga 13 grams, root tuber of aromatic turmeric 9 grams, 18 grams, Radix Glycyrrhizae, realgar 7 grams.
As a kind of prioritization scheme:
Described Chinese medicine preparation is made up of the Chinese herb of following weight part:
Semen Raphani 20 grams, agalloch eaglewood 20 grams, tsaoko 20 grams, 20 grams, cardamom, 20 grams, rascal, Ligusticum wallichii 20 grams, Root of Indigowoad 20 grams, 20 grams, Root of Sixpetal Clematis, Herba Agrimoniae 20 grams, 8 grams, fried dry paint, peppermint 8 grams, 15 grams, turmeric, the bighead atractylodes rhizome 8 grams, the root of three-nerved spicebush 8 grams, blackberry lily 15 grams, chrysanthemum 8 grams, the tuber of dwarf lilyturf 8 grams, Radix Codonopsis 20 grams, desert cistanche 20 grams, the wind-weed 8 grams, marine alga 15 grams, root tuber of aromatic turmeric 10 grams, 20 grams, Radix Glycyrrhizae, realgar 8 grams.
The instructions of taking of Chinese medicine preparation of the present invention is: after the raw material Chinese medicine of above-mentioned weight proportion being mixed, 1 dose/day, and every agent head decocts the 400mL that adds water, and warm fire boils 25 minutes, gets juice 200mL; Two decoct the 300mL that adds water, and warm fire boils 20 minutes, gets juice 150mL. Two decoct mixing, sooner or later heat clothes, and 30 doses is a course for the treatment of.Stop medicine between the course for the treatment of 2～3 days, then go lower 1 course for the treatment of, serve on 2～3 courses for the treatment of.
The raw material Chinese medicine of above-mentioned Chinese medicine preparation:
Semen Raphani, taste is pungent, sweet, and property is put down; Return spleen, stomach, lung channel. There is the de-swelling that helps digestion, effect of lowering the adverse-rising QI to resolve phlegm. Modern pharmacological research, proves that Semen Raphani is containing antimicrobial substance radish element, all has certain restraining effect to streptococcus pneumoniae, staphylococcus, intestinal bacteria, suis etc.
Agalloch eaglewood, taste is pungent, bitter, warm in nature; Return spleen, stomach, kidney channel; Gas perfume row is loose, falls and can rise; There is promoting the circulation of qi warming middle-JIAO to send down the adverse QI, effect of warm kidney helping inspiration to relieve asthma. Main coldness and pain in the epigastrium; Circulation of vital energy in the wrong direction person ceases; Gastrofrigid vomiting hiccup; Waist knee void is cold; Asthenia of the large intestine is secret; Urine gas drenches.
Tsaoko, taste is pungent, warm in nature; Return spleen, stomach warp. Having eliminating dampness except cold, eliminate the phlegm preventing malaria, effect of helping digestion unrest.
Cardamom, pungent can break stagnant, and perfume (or spice) can enter spleen, warm can dispelling cold and eliminating dampness, there is good promoting the circulation of qi effect, therefore Jiao, pain in the chest and abdomen, syncope due to pathogenic cold are vomitted in main temperature and in cold visitor.
Rascal, bitter, pungent, warm in nature; Return liver, courage, stomach warp. There is soothing the liver relieving stagnant Qi, the stagnant effect of long-pendingization that disappear.
Ligusticum wallichii, taste is pungent, warm in nature; Return liver, courage, pericardium warp. There is blood-activating and qi-promoting, effect of wind-expelling pain-stopping. For pacifying nerve, positive head public attention pain, abdominal mass is suffered from abdominal pain, chest side of body shouting pain, tumbling and swelling, headache, rheumatic arthralgia.
Root of Indigowoad cures mainly maculae caused by violent heat pathogen; High heat headache; Major part pestilence; Tongue is secretly dark reddish purple, scarlet fever; Erysipelas; Mumps; Larynx numbness; Sore is swollen, carbuncle swells; Varicella; Measles; Hepatitis; Influenza, epidemic meningitis, encephalitis, pneumonia, coma tells nosebleed, and pharynx is swollen, pinkeye, sore rash; Can preventing and treating epidemic encephalitis type B, acute, chronic hepatitis, mumps, osteomyelitis, gram-positive and negative bacteria are had bacteriostatic action by root decoction, and the acetone extract of root and the acetone extract of leaf also have bacteriostatic action. Streptococcus aureus is had restraining effect by Root of Indigowoad ether extract; The influenza virus PR' strain that chicken embryo is infected by Radix Isatidis injection and the 68-1 strain of capital section all have obvious restraining effect, and hepatitis B virus thymus nucleic acid is had restraining effect by Root of Indigowoad decoction, and Root of Indigowoad has the effect killing Leptospira in vitro.
Root of Sixpetal Clematis, taste hardship pungent, salty, micro-, warm in nature; Mild toxicity; Return bladder, Liver Channel. Root of Sixpetal Clematis has wind-damp dispelling, the meridian dredging, the bone that disappears is choked three large effects, because its property is walked to alter, pharmacology confirms its effect releasing place's smooth muscle spasms such as oesophagus, segmental bronchus, ureter, stomach and biliary tract in addition, and has stronger anti-inflammatory analgetic effect.
Bacillus subtilus, streptococcus aureus, intestinal bacteria, Pseudomonas aeruginosa, shigella flexneri and Corynebacterium diphtheriae etc. are all had restraining effect in vitro by hot water or the ethanol immersion liquid of Herba Agrimoniae, and Bacillus tuberculosis is also had restraining effect. Full grass water extract and water-ol extract, rabbit conjunctivitis tori seed oil or staphylococcal infections caused, all has antiinflammation, and this effect is relevant containing generating the tan tannin of acid anhydride of condensed type with Herba Agrimoniae.
Fried dry paint, pungent temperature dissipating bind, enters Liver Channel blood system, and energy promoting blood circulation to restore menstrual flow, the stasis of blood of dispelling is broken. Can also killing worm in addition to dissipate, by stomach, all are tangible stagnant, and stomach is both clear, then the five internal organs are from peace.
Peppermint has dispelling wind and heat pathogens, the clear profit head, profit pharynx promoting eruption, effect of dispersing the stagnated live-QI to relieve the stagnation of QI. Also having antivirus action in addition, virus ECHO11 strain is had restraining effect by peppermint water decoction, and mentha camphor has very strong germicidal action.
Turmeric, taste is pungent, bitter, warm in nature;Return the spleen channel, Liver Channel. There is broken blood gas, inducing meastruation to relieve menalgia effect. Turmeric has wide material sources, cheap, security height, without advantages such as toxicity, side effect are little, is with a wide range of applications in Dermatology Department. Ultraviolet can also be absorbed, promote skin regeneration, treatment burn, scald, skin ulcer are also had certain curative effect. The volatile oil extracted from turmeric has unique fragrance characteristic, and wherein contained curcumine (curcumin) can suppress super-oxide to generate, thus reduce H2O2 and cause cytotoxicity, human keratinocyte is shielded; Can obviously reduce the roughness of human facial skin, be the active drug of delay skin aging.
Bighead atractylodes rhizome sweetness and bitterness is warm in nature, main returns taste warp, and taking strong spleen, eliminating dampness for main effect, what praised by forefathers is " spleen air making-up and spleen enlivening first key medicine ". The spleen has the function to transport and transform nutrients because of deficiency of spleen-QI, and transporting is lost strong, often water wet in raw, cause food less, loose stool or have loose bowels, all cards under phlegm and retained fluid, oedema, band. The bighead atractylodes rhizome had both been longer than tonifying Qi with the strong fortune of multiple spleen, again can eliminating dampness, diuresis with except damp evil.
The root of three-nerved spicebush, taste is pungent, warm in nature; Return lung, spleen, kidney, bladder warp. The root of three-nerved spicebush not only has pleasant pain relieving, effect of dispelling cold and warming the kidney, and the function in excited gastrointestinal smooth muscle, relieving inflammation and relaxing pain, guarantor liver, anti-freezing, promotion blood coagulation, hemostasis.
Blackberry lily, cold nature, toil; Enter lung, Liver Channel. Having clearing heat and detoxicating, profit swallows the effect eliminated the phlegm. Pharmacology proves, blackberry lily decocting liquid has stronger anti-scorching germicidal action.
Chrysanthemum, taste is micro-pungent, sweet, bitter, cold nature. Chrysanthemum has number of chemical composition, comprise volatile oil, flavonoid compound, amino acid, trace element and other. Modern pharmacological research is thought, chrysanthemum for inflammation antibacterial, anti-, anti-oxidant, anti-ageing, vasodilator, blood pressure falls, antitumor and drive the aspect such as plumbous there is stronger throttling processed.
The tuber of dwarf lilyturf, property is sweet, and micro-hardship is cool, returns stomach, lung, the heart channel of Hang-Shaoyin, has Yin-nourishing and body fluid promoting, and moistening lung clears away heart-fire, cough-relieving, the function of relieving restlessness. Pharmacological research shows that the tuber of dwarf lilyturf raises peripheral leukocytes in addition, increases immunizing power, it is also possible to improve the blood supply of heart, the effect of anti-arrhythmia, also have certain calmness and anti-microbial effect. Cure mainly consumption of body fluid caused by febrile disease, vexed, thirsty, dry throat lung heat, cough, pulmonary tuberculosis etc.
Radix Codonopsis, taste is sweet, and property is put down; Return spleen, lung channel. Power energy tonifying spleen nourishing the stomach, moistening lung is promoted the production of body fluid, tendon transport in gas, strong spleen fortune and not dry, grow stomach-Yin and do not wet, moistening lung and do not violate cold and cool, nourish blood and partially do not grow greasy, inspire clear sun, gas in vibration, and without just dry fraud, there is good invigorating the spleen and replenishing QI, the effect promoted the production of body fluid and nourish blood.
Desert cistanche, taste is sweet, salty, warm in nature; Return kidney, large intestine channel. There is kidney invigorating and YANG supporting, strong benefiting essence-blood, the effect relaxed bowel.
The wind-weed, bitter, sweet, cold in nature; Return lung, stomach, kidney channel. There is heat-clearing and fire-purging, nourshing Yin and drynsessmoistening prescription effect. Pharmacology proves, tubercule bacillus H37RV is had stronger restraining effect by the extracts such as wind-weed ethanol, ether.
Marine alga is bitter, salty, cold in nature; Return lung, stomach, kidney channel. There is softening and resolving hard mass, effect of dissolving phlegm profit water. Pharmaceutical research proves, seaweed extracted liquor proteoglycan can resist various virus, comprising hiv virus and carcinogenic RNA viruses.
Root tuber of aromatic turmeric is the gas medicine of blood system, both regulates the flow of vital energy, again stagnation resolvation, and dialectical is the conventional this product of qi depression to blood stasis person. The disease of qi depression to blood stasis is had on clinical, such as myocarditis, coronary heart disease feeling of oppression and pain in the chest or companion's stenocardia, chronic hepatopathy or companion's portal hypertension, immunological disease lung damage or companion pulmonary hypertension, Chronic Cholecystitis & Cholelithiasis, associated with acute ureterolithiasis blood urine etc., these all need to treat by the method for regulating the flow of QI to dissipate blood stasis, root tuber of aromatic turmeric is applicable medicine, can be equal to use with radix bupleuri, the root of herbaceous peony.Modern pharmacology proves, Radix Curcumae volatile oil injection liquid can strengthen fibrinolytic, and passes through raising CAMP content and obvious anticoagulant, thus can play anticoagulant effect.
Radix Glycyrrhizae, taste is sweet, and property is put down; The thoughts of returning home, spleen, lung, stomach warp. Have and invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm for arresting cough, relieving spasm to stop pain, effect of coordinating the actions of various ingredients in a prescription. Have removing toxic substances, eliminate the phlegm, pain relieving, spasmolysis is so that the pharmacological action such as anticancer.
Realgar, taste is pungent, temperature; Return liver, large intestine channel. There is removing dampness and killing parasites, control mange, rob effect of phlegm removing toxic substances. Pharmaceutical research shows, and realgar water decoction is external has restraining effect in various degree to the sick fungi of the various skin such as trichophyton. External have killing action to streptococcus aureus, intestinal bacteria, and can suppress growth human-like, Bacillus tuberculosis bovis.
Traditional Chinese medical science medical science thinks that esophageal squamous cell carcinoma belongs to " dysphagic " category, and the generation of esophageal squamous cell carcinoma and internal organs gas blood function are not enough, feel again external heresy, or raw in perverse trend, causes the stagnation of the circulation of vital energy, phlegm resistance, the blood stasis of blood etc. and ties in oesophagus mutually, does not with the passing of time fall apart, turn to cancerous swelling. Its disease character is deficiency in origin and excess in superficiality, and sick position, at oesophagus, belongs to stomach Qi and led, closely related with liver, spleen, kidney, mostly is the card of deficiency in origin and excess in superficiality. Mark is real is that the obstruction of the circulation of vital energy, phlegm resistance, the blood stasis of blood etc. are held concurrently mutually; This void is that body fluid deficiency blood is dry, and deficiency of YIN affecting YANG etc. form esophageal stricture jointly, and body fluid dries up, and is its crucial interpretation of the cause, onset and process of an illness. Therefore treatment when taking qi-restoratives, Xie Yu, eliminate the phlegm, change poison, by the stasis of blood as principle.
In Chinese medicine preparation of the present invention, the tuber of dwarf lilyturf, Radix Codonopsis, desert cistanche, the wind-weed, agalloch eaglewood can be nourishing and suppressing Yang, invigorating the spleen and replenishing QI, moisturizes and promotes the production of body fluid; The bighead atractylodes rhizome, the root of three-nerved spicebush, Radix Glycyrrhizae air making-up and spleen enlivening, eliminating dampness are loose cold, beneficial gas and in; Totally 5 can strengthen the body resistance to consolidate the constitution, it is to increase the antiviral anti-cancer of human body and immunological competence; Turmeric, Ligusticum wallichii, fried dry paint, root tuber of aromatic turmeric energy promoting blood circulation to restore menstrual flow, regulating the flow of QI to dissipate blood stasis, promote that esophagus local blood microcirculation, elimination local blood stasis blocking are stagnant; Root of Indigowoad, Root of Sixpetal Clematis, Herba Agrimoniae, peppermint, blackberry lily, chrysanthemum, realgar share can clearing heat and detoxicating, dispel rheumatism, profit pharynx promoting eruption, dispersing the stagnated live-QI to relieve the stagnation of QI, effectively dispel the toxic dampness and heat that esophagus local retains; Marine alga, tsaoko, cardamom, rascal promoting the circulation of qi are reduced phlegm, softening and resolving hard mass, long-pendingization that disappear are stagnant, and the division of inhibition tumor cell, promotes the absorption of Inflammatory substances.
In addition, the disease of " dysphagic " mainly because of the turbid interior life of phlegm, blockage of qi mechanism by phlegm, qi depression to blood stasis, the turbid heap soil or fertilizer over and around the roots of blood stasis of blood phlegm gathers oesophagus, the narrow mountain pass of oesophagus, caused by stomach Qi rising, with the passing of time the raw weary source of gas bloodization, and resembling of occurring that asthenia of qi and blood loses, added Semen Raphani in we, its taste is pungent, property is put down, returning spleen, stomach, lung channel, the merit of its lower gas coordinates the medicine of the tonifying Qi such as Radix Codonopsis, can make vital qi foot, and foul smell is fallen, gas load blood, vital qi foot, blood must be smooth, treat that gas blood fills, the medicine being equipped with the invigorating blood circulation silt such as Ligusticum wallichii, root tuber of aromatic turmeric again, cleanses stagnant, viral, and its disease must heal.
Clinical trial proves, originally can link closely the interpretation of the cause, onset and process of an illness, treat both principal and secondary aspect of disease, play that removing toxic substances is reduced phlegm altogether, nourishing Yin and promoting production of body fluid, heat-clearing dissipating bind, promoting blood circulation and removing blood stasis, long-pending effect of assaulting fortified position brokenly, while suppressing and killing and wounding cancer cells, do not injure normal cell, and the functions such as righting of getting rid of evils can be obtained, effectively extend esophageal squamous cell carcinoma patient's life-span, improve its life quality preferably, it is worth clinical application.
For investigating clinical efficacy and the security of medicine of the present invention further, we have selected 51 example esophageal squamous cell carcinoma patients and have carried out clinical experiment. Wherein man 40 example, female 11 example, 32～70 years old age, average 51.5 years old.Whole case is and checks, through the inspection of esophagoscope biopsy pathology or Esophageal Netting Cells, the inpatient made a definite diagnosis. All patients are according to TNM clinical stages, and I phase 18 example, II phase 15 example, III phase 14 example, IV phase 4 is routine. The pathological diagnosis of all patients is all squamous cell carcinoma. All cases all refuse operation, radiotherapy and chemotherapeutic treatment.
Exclusion standard: get rid of: 1. hepatic and renal function is abnormal; 2. hemopoietic function of bone marrow is abnormal; 3. far-end transfer; 4. infecting, white blood cell count(WBC) is obvious; 5. severe cardiovascular disease; 6. Ka Shi scoring less than 70, can not maintain orthobiosis or work.
Methods for the treatment of:
All patients all take Chinese medicine preparation of the present invention, and by after the mixing of the raw material Chinese medicine of above-mentioned weight proportion (add with disease and subtract), 1 dose/day, every agent head decocts the 400mL that adds water, and warm fire boils 25 minutes, gets juice 200mL; Two decoct the 300mL that adds water, and warm fire boils 20 minutes, gets juice 150mL. Two decoct mixing, sooner or later heat clothes. It within 30 days, it is a course for the treatment of.
Criterion of therapeutical effect:
1, clinical efficacy standard:
Formulate with reference to efficacy assessment standard dysphagic in " tcm internal medicine illness Standardization of diagnosis and curative effect ".
Curing: clinical symptom disappearance, barium meal X line perspective, take the photograph sheet or oesophagoscope inspection and recover normal, life quality Ka Shi marks and reaches 100 points.
Effective: clinical symptom is improved, barium meal X line perspective, take the photograph sheet or oesophagoscope inspection obviously takes a turn for the better, life quality Ka Shi marks increases by 20 points.
Effective: clinical symptom is improved substantially, barium meal X line perspective, take the photograph sheet or oesophagoscope inspection take a favorable turn, life quality Ka Shi increase of marking is less than 20 points
Invalid: clinical symptom and sign are all without improvement or deterioration, and life quality Ka Shi marks without improving.
2, tumor regression criterion of therapeutical effect:
Efficacy assessment standard is treated according to WHO solid tumor drugs.
Complete incidence graph (CR): tumour is cured completely, physical symptom recovers normal.
Partial rcsponse (PR): tumor area reduces obviously, and physical symptom obviously improves.
Stable (NR): tumor area is unchanged, and physical symptom is maintained the statusquo.
Worsening (PD): tumor area increases, physical symptom worsens.
Treatment result:
1, clinical efficacy evaluation:
After treatment, the I phase 18 example patient in have efficiency be 100%, II the phase 15 example patient in have efficiency be 86.7%, III the phase 14 example patient in have efficiency be 78.6%, IV the phase 4 example patient in have efficiency to be 75%, always have efficiency to be 88.2%, result for the treatment of is remarkable. Detailed results is in table 1.
Table 1: example patient clinical efficacy result table
2, carninomatosis stove minification:
In 51 example patients, cases of complete remission 16 example, part reduces 12 examples, stablizes 20 examples, worsens 3 examples, always has efficiency 94.1%. Detailed results is in table 2.
Table 2: patient's carninomatosis stove reduces result table
Completely dissolve CR Part reduces PR Stablize NR Worsen PD Always there is efficiency CR+PR
16 (31.4%) 12 (23.5%) 20 (39.2%) 3(5.9) 94.1
3, efficacy analysis lifetime:
After treatment, all patients are carried out regular follow-up, it has been found that patient's life quality improves, and the life-span is obviously extended. Refer to table 3.
Table 3: patient's distribution situation lifetime table
Above result shows, the present invention, based on the conditioning of general, is conceived to local, and by overall medication, righting reinforcing, the vigour of conditioning esophageal squamous cell carcinoma patient, strengthens resistibility and the immunizing power of patient, it is to increase physical function. Effectively act on tumour simultaneously and stop recurrence and the transfer of cancer cells, effectively extend esophageal squamous cell carcinoma patient's life-span, improve its life quality preferably, be worth clinical application.
Embodiment
Embodiment 1: a kind of Chinese medicine preparation treating esophageal squamous cell carcinoma, chooses Semen Raphani 10 grams, agalloch eaglewood 10 grams, tsaoko 10 grams, 10 grams, cardamom, 10 grams, rascal, Ligusticum wallichii 10 grams, Root of Indigowoad 10 grams, 10 grams, Root of Sixpetal Clematis, Herba Agrimoniae 10 grams, 5 grams, fried dry paint, peppermint 5 grams, 10 grams, turmeric, the bighead atractylodes rhizome 5 grams, the root of three-nerved spicebush 5 grams, blackberry lily 10 grams, chrysanthemum 5 grams, the tuber of dwarf lilyturf 5 grams, Radix Codonopsis 10 grams, desert cistanche 10 grams, the wind-weed 5 grams, marine alga 5 grams, root tuber of aromatic turmeric 5 grams, 10 grams, Radix Glycyrrhizae, realgar 5 grams.
Embodiment 2: a kind of Chinese medicine preparation treating esophageal squamous cell carcinoma, chooses Semen Raphani 12 grams, agalloch eaglewood 12 grams, tsaoko 12 grams, 12 grams, cardamom, 12 grams, rascal, Ligusticum wallichii 12 grams, Root of Indigowoad 12 grams, 12 grams, Root of Sixpetal Clematis, Herba Agrimoniae 12 grams, 5 grams, fried dry paint, peppermint 6 grams, 11 grams, turmeric, the bighead atractylodes rhizome 5 grams, the root of three-nerved spicebush 6 grams, blackberry lily 11 grams, chrysanthemum 6 grams, the tuber of dwarf lilyturf 5 grams, Radix Codonopsis 12 grams, desert cistanche 12 grams, the wind-weed 5 grams, marine alga 7 grams, root tuber of aromatic turmeric 6 grams, 12 grams, Radix Glycyrrhizae, realgar 6 grams.
Embodiment 3: a kind of Chinese medicine preparation treating esophageal squamous cell carcinoma, chooses Semen Raphani 14 grams, agalloch eaglewood 14 grams, tsaoko 14 grams, 14 grams, cardamom, 14 grams, rascal, Ligusticum wallichii 14 grams, Root of Indigowoad 14 grams, 14 grams, Root of Sixpetal Clematis, Herba Agrimoniae 14 grams, 6 grams, fried dry paint, peppermint 6 grams, 12 grams, turmeric, the bighead atractylodes rhizome 6 grams, the root of three-nerved spicebush 6 grams, blackberry lily 12 grams, chrysanthemum 6 grams, the tuber of dwarf lilyturf 6 grams, Radix Codonopsis 14 grams, desert cistanche 14 grams, the wind-weed 6 grams, marine alga 9 grams, root tuber of aromatic turmeric 7 grams, 14 grams, Radix Glycyrrhizae, realgar 6 grams.
Embodiment 4: a kind of Chinese medicine preparation treating esophageal squamous cell carcinoma, chooses Semen Raphani 16 grams, agalloch eaglewood 16 grams, tsaoko 16 grams, 16 grams, cardamom, 16 grams, rascal, Ligusticum wallichii 16 grams, Root of Indigowoad 16 grams, 16 grams, Root of Sixpetal Clematis, Herba Agrimoniae 16 grams, 6 grams, fried dry paint, peppermint 7 grams, 13 grams, turmeric, the bighead atractylodes rhizome 6 grams, the root of three-nerved spicebush 7 grams, blackberry lily 13 grams, chrysanthemum 6 grams, the tuber of dwarf lilyturf 7 grams, Radix Codonopsis 16 grams, desert cistanche 16 grams, the wind-weed 6 grams, marine alga 11 grams, root tuber of aromatic turmeric 8 grams, 16 grams, Radix Glycyrrhizae, realgar 7 grams.
Embodiment 5: a kind of Chinese medicine preparation treating esophageal squamous cell carcinoma, chooses Semen Raphani 18 grams, agalloch eaglewood 18 grams, tsaoko 18 grams, 18 grams, cardamom, 18 grams, rascal, Ligusticum wallichii 18 grams, Root of Indigowoad 18 grams, 18 grams, Root of Sixpetal Clematis, Herba Agrimoniae 18 grams, 7 grams, fried dry paint, peppermint 7 grams, 14 grams, turmeric, the bighead atractylodes rhizome 7 grams, the root of three-nerved spicebush 7 grams, blackberry lily 14 grams, chrysanthemum 7 grams, the tuber of dwarf lilyturf 7 grams, Radix Codonopsis 18 grams, desert cistanche 18 grams, the wind-weed 7 grams, marine alga 13 grams, root tuber of aromatic turmeric 9 grams, 18 grams, Radix Glycyrrhizae, realgar 7 grams.
Embodiment 6: a kind of Chinese medicine preparation treating esophageal squamous cell carcinoma, chooses Semen Raphani 20 grams, agalloch eaglewood 20 grams, tsaoko 20 grams, 20 grams, cardamom, 20 grams, rascal, Ligusticum wallichii 20 grams, Root of Indigowoad 20 grams, 20 grams, Root of Sixpetal Clematis, Herba Agrimoniae 20 grams, 8 grams, fried dry paint, peppermint 8 grams, 15 grams, turmeric, the bighead atractylodes rhizome 8 grams, the root of three-nerved spicebush 8 grams, blackberry lily 15 grams, chrysanthemum 8 grams, the tuber of dwarf lilyturf 8 grams, Radix Codonopsis 20 grams, desert cistanche 20 grams, the wind-weed 8 grams, marine alga 15 grams, root tuber of aromatic turmeric 10 grams, 20 grams, Radix Glycyrrhizae, realgar 8 grams.
Below by concrete case, the Chinese medicine preparation curative effect of the present invention is verified further:
Case 1
Bear, man, 66 years old. Patient is because breastbone pain when dysphagia, feed removes hospital admission before 5 years, and X ray examination has Esophageal Middle Segment narrow, mucosal discontinuities, the long about 4cm of pathology, confirms through making dragging in esophagus and pathology, is diagnosed as esophageal squamous cell carcinoma. Because patient is reluctant that row is performed the operation and chemotherapy, under friend recommendation, take treatment by Chinese herbs of the present invention. Observing patient's symptom, patient takes medicine a course for the treatment of, can eat milk bubble bread gradually, and tell foam and obviously alleviate, defecate logical, and spirit takes a turn for the better. But retrosternal pain sense when still having dry and feed. 1 course for the treatment of of continual cure, patient can take food soft steamed bun and rice, and life is taken care of oneself, in high spirits. Symptom after 3 courses for the treatment of of taking medicine takes a favorable turn. Focus reduces gradually. Patient reduces administration time and medicine amount carries out after treatment gradually afterwards, and life is good so far.
Case 2
Wear certain, man, 60 years old. When patient diet occurred before 8 years, esophagus is sent out and is choked, dysphagia, and pain is vomitted repeatedly, have a dizzy spell, malaise, underfooting send out symptoms such as wafing, through examination in hospital, make a definite diagnosis as esophageal squamous cell carcinoma.Though namely in local hospital chemotherapy 2 cycle and radiotherapy 42 days, difficulty of still taking food, vomiting constantly, hurt like hell, weight loss, the state of an illness has no improvement. Taking medicine of the present invention after being introduced to treat, after 1 course for the treatment of of taking medicine, appetite increases, and diet is swallowed smooth and easy, seldom vomits, and pain subtracts and disappears, from head to foot not weak, moreover it is possible to often do a little housework, and after taking medicine 3 months, examination in hospital display is basic recovers normal. For consolidate curative effect, after continuing to take again 1 course for the treatment of, various symptom completely dissolve, check display: barium agent is smooth by esophagus, expansion is good, and the smooth mucous membrane of tube wall is out of shape regular. Patient stops medication, and life is good so far.
Case 3
Ouyang, female, 58 years old. Patient removes hospital admission because of difficulty of taking food before 3 years, and X ray examination distal esophagus has 2. The filling defect of 6cm length, mucosal discontinuities, turns out to be esophageal squamous cell carcinoma through dragging in esophagus pathology. Upon somebody's introduction, starting to take medicine of the present invention and treat, take medicine 1 course for the treatment of, the state of an illness takes a favorable turn, and fever stops, it is possible to eating noodles, thin rice gruel. Continuing to take 2 courses for the treatment of, health obviously takes a turn for the better, and body weight increases by 2 kilograms, and the every index of examination in hospital is improved greatly. Patient adhered to that regularly taking this medicine carried out conditioning and treating afterwards, and life is good so far.

Claims (7)

1. treat the Chinese medicine preparation of esophageal squamous cell carcinoma for one kind, it is characterised in that, described Chinese medicine preparation is made up of the Chinese herb of following weight part:
Semen Raphani 10-20 gram, agalloch eaglewood 10-20 gram, tsaoko 10-20 gram, 10-20 gram, cardamom, 10-20 gram, rascal, Ligusticum wallichii 10-20 gram, Root of Indigowoad 10-20 gram, 10-20 gram, Root of Sixpetal Clematis, Herba Agrimoniae 10-20 gram, 5-8 gram, fried dry paint, peppermint 5-8 gram, 10-15 gram, turmeric, bighead atractylodes rhizome 5-8 gram, root of three-nerved spicebush 5-8 gram, blackberry lily 10-15 gram, chrysanthemum 5-8 gram, tuber of dwarf lilyturf 5-8 gram, Radix Codonopsis 10-20 gram, desert cistanche 10-20 gram, wind-weed 5-8 gram, marine alga 5-15 gram, root tuber of aromatic turmeric 5-10 gram, 10-20 gram, Radix Glycyrrhizae, realgar 5-8 gram.
2. Chinese medicine preparation according to claim 1, it is characterised in that, described Chinese medicine preparation is made up of the Chinese herb of following weight part:
Semen Raphani 10 grams, agalloch eaglewood 10 grams, tsaoko 10 grams, 10 grams, cardamom, 10 grams, rascal, Ligusticum wallichii 10 grams, Root of Indigowoad 10 grams, 10 grams, Root of Sixpetal Clematis, Herba Agrimoniae 10 grams, 5 grams, fried dry paint, peppermint 5 grams, 10 grams, turmeric, the bighead atractylodes rhizome 5 grams, the root of three-nerved spicebush 5 grams, blackberry lily 10 grams, chrysanthemum 5 grams, the tuber of dwarf lilyturf 5 grams, Radix Codonopsis 10 grams, desert cistanche 10 grams, the wind-weed 5 grams, marine alga 5 grams, root tuber of aromatic turmeric 5 grams, 10 grams, Radix Glycyrrhizae, realgar 5 grams.
3. Chinese medicine preparation according to claim 1, it is characterised in that, described Chinese medicine preparation is made up of the Chinese herb of following weight part:
Semen Raphani 12 grams, agalloch eaglewood 12 grams, tsaoko 12 grams, 12 grams, cardamom, 12 grams, rascal, Ligusticum wallichii 12 grams, Root of Indigowoad 12 grams, 12 grams, Root of Sixpetal Clematis, Herba Agrimoniae 12 grams, 5 grams, fried dry paint, peppermint 6 grams, 11 grams, turmeric, the bighead atractylodes rhizome 5 grams, the root of three-nerved spicebush 6 grams, blackberry lily 11 grams, chrysanthemum 6 grams, the tuber of dwarf lilyturf 5 grams, Radix Codonopsis 12 grams, desert cistanche 12 grams, the wind-weed 5 grams, marine alga 7 grams, root tuber of aromatic turmeric 6 grams, 12 grams, Radix Glycyrrhizae, realgar 6 grams.
4. Chinese medicine preparation according to claim 1, it is characterised in that, described Chinese medicine preparation is made up of the Chinese herb of following weight part:
Semen Raphani 14 grams, agalloch eaglewood 14 grams, tsaoko 14 grams, 14 grams, cardamom, 14 grams, rascal, Ligusticum wallichii 14 grams, Root of Indigowoad 14 grams, 14 grams, Root of Sixpetal Clematis, Herba Agrimoniae 14 grams, 6 grams, fried dry paint, peppermint 6 grams, 12 grams, turmeric, the bighead atractylodes rhizome 6 grams, the root of three-nerved spicebush 6 grams, blackberry lily 12 grams, chrysanthemum 6 grams, the tuber of dwarf lilyturf 6 grams, Radix Codonopsis 14 grams, desert cistanche 14 grams, the wind-weed 6 grams, marine alga 9 grams, root tuber of aromatic turmeric 7 grams, 14 grams, Radix Glycyrrhizae, realgar 6 grams.
5. Chinese medicine preparation according to claim 1, it is characterised in that, described Chinese medicine preparation is made up of the Chinese herb of following weight part:
Semen Raphani 16 grams, agalloch eaglewood 16 grams, tsaoko 16 grams, 16 grams, cardamom, 16 grams, rascal, Ligusticum wallichii 16 grams, Root of Indigowoad 16 grams, 16 grams, Root of Sixpetal Clematis, Herba Agrimoniae 16 grams, 6 grams, fried dry paint, peppermint 7 grams, 13 grams, turmeric, the bighead atractylodes rhizome 6 grams, the root of three-nerved spicebush 7 grams, blackberry lily 13 grams, chrysanthemum 6 grams, the tuber of dwarf lilyturf 7 grams, Radix Codonopsis 16 grams, desert cistanche 16 grams, the wind-weed 6 grams, marine alga 11 grams, root tuber of aromatic turmeric 8 grams, 16 grams, Radix Glycyrrhizae, realgar 7 grams.
6. Chinese medicine preparation according to claim 1, it is characterised in that, described Chinese medicine preparation is made up of the Chinese herb of following weight part:
Semen Raphani 18 grams, agalloch eaglewood 18 grams, tsaoko 18 grams, 18 grams, cardamom, 18 grams, rascal, Ligusticum wallichii 18 grams, Root of Indigowoad 18 grams, 18 grams, Root of Sixpetal Clematis, Herba Agrimoniae 18 grams, 7 grams, fried dry paint, peppermint 7 grams, 14 grams, turmeric, the bighead atractylodes rhizome 7 grams, the root of three-nerved spicebush 7 grams, blackberry lily 14 grams, chrysanthemum 7 grams, the tuber of dwarf lilyturf 7 grams, Radix Codonopsis 18 grams, desert cistanche 18 grams, the wind-weed 7 grams, marine alga 13 grams, root tuber of aromatic turmeric 9 grams, 18 grams, Radix Glycyrrhizae, realgar 7 grams.
7. Chinese medicine preparation according to claim 1, it is characterised in that, described Chinese medicine preparation is made up of the Chinese herb of following weight part:
Semen Raphani 20 grams, agalloch eaglewood 20 grams, tsaoko 20 grams, 20 grams, cardamom, 20 grams, rascal, Ligusticum wallichii 20 grams, Root of Indigowoad 20 grams, 20 grams, Root of Sixpetal Clematis, Herba Agrimoniae 20 grams, 8 grams, fried dry paint, peppermint 8 grams, 15 grams, turmeric, the bighead atractylodes rhizome 8 grams, the root of three-nerved spicebush 8 grams, blackberry lily 15 grams, chrysanthemum 8 grams, the tuber of dwarf lilyturf 8 grams, Radix Codonopsis 20 grams, desert cistanche 20 grams, the wind-weed 8 grams, marine alga 15 grams, root tuber of aromatic turmeric 10 grams, 20 grams, Radix Glycyrrhizae, realgar 8 grams.
CN201610124694.9A 2016-03-04 2016-03-04 Traditional Chinese medicine preparation for treating esophageal squamous carcinoma Pending CN105664047A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104173947A (en) * 2014-09-12 2014-12-03 商斌 Traditional Chinese medicine preparation for resisting esophagus cancer
CN104873692A (en) * 2015-06-11 2015-09-02 伦俊杰 Traditional Chinese medicine preparation for treating esophagus cancer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104173947A (en) * 2014-09-12 2014-12-03 商斌 Traditional Chinese medicine preparation for resisting esophagus cancer
CN104873692A (en) * 2015-06-11 2015-09-02 伦俊杰 Traditional Chinese medicine preparation for treating esophagus cancer

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Application publication date: 20160615