CN105663966A - Composition used for slimming and reducing lipid - Google Patents

Composition used for slimming and reducing lipid Download PDF

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Publication number
CN105663966A
CN105663966A CN201610128292.6A CN201610128292A CN105663966A CN 105663966 A CN105663966 A CN 105663966A CN 201610128292 A CN201610128292 A CN 201610128292A CN 105663966 A CN105663966 A CN 105663966A
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reducing
weight
compositions
pulverize
alcohol
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时贞平
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Jinhua Huasai Pharmaceutical Research Institute Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8967—Lilium, e.g. tiger lily or Easter lily
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
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    • A61K31/47—Quinolines; Isoquinolines
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    • A61K36/02—Algae
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    • A61K36/07—Basidiomycota, e.g. Cryptococcus
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    • A61K36/185—Magnoliopsida (dicotyledons)
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Abstract

The invention relates to a composition used for slimming and reducing lipid. The invention discloses a new composition formed by lily, galangal, 1-deoxynojirimycin, nuciferine, pagodatree flower buds, kudzu vine root, poria cocos, kelp, lophatherum gracile and functional oligosaccharide, calcium pyruvate and/or L-carnitine also can be added, series preparations such as capsules, tablets, powder, granules, oral liquid and medicinal tea can be prepared according to practical requirements, and a more advanced dosage form can be prepared to be used by a consumer by virtue of a newer technology. The composition can be applied to compositions of common food, functional food, health care products and medicines and can be used for slimming and lipid-reducing health care of obese people and prevention and treatment of obesity.

Description

A kind of compositions for weight-reducing, blood fat reducing
Technical field
The present invention relates to a kind of compositions for weight-reducing, blood fat reducing, the compositions of the present invention can be used for the compositions of bread and cheese, functional food, health product and medicine and directly uses or refine out use after corresponding active component through modern means of science and technology, make applicable preparation, be widely used in the Crowded health protections such as the metabolic syndrome such as obese people, hyperlipidemia, treatment category.
Background technology
Obesity is the healthy topic of what a Sheng of a specified duration did not wane, associates the population in the whole world about 13%. According to the up-to-date report display of one, obesity community of the world (WOF), unless government takes further action, ending global obesity rates in 2025 will rise 4% again.
Overweight and fat can cause a series of health problem, including heart disease, apoplexy, type-II diabetes and cancer etc. Since nineteen eighty, the prevalence that the whole world is fat has increased and has exceeded one times. Data rise violently largely to be increased owing to the amount of food rich in fat, Sugared beverages, and the motionless working environment of sitting, urban population increase etc.
In order to slow down degradating trend, containment potential risk, World Health Organization (WHO) (WHO) releases a Universal Mobile plan 2013--the year two thousand twenty prevention and control noninfectious problem. Plan is intended to call world community government to participate in estimating compared to 2010, overweight and fat ratio in 2025.
In report also prediction cut-off 2025, the whole world nearly 2,700,000,000 adults can overweight or fat (BMI 25), add more than 700,000,000 than 2014 annual datas. And this is wherein, the contribution surely belonging to the U.S. is maximum, and estimating more than 190,000 adults will be overweight or fat at coming 10 years.
Obesity community of world chairman professor WalmirCoutinho points out, problem of obesity has spread to almost each country of the whole world. Government's this trend already known can not be developed as one pleases, and they have agreed to solve problem of obesity and reduce fat prevalence in 2025 to level in 2010. But, for realizing this target, take action in time now. Doctor Lobstein points out, national governments need to release fat, the overweight strategy of reply, including formulating the strict regulations forbidding selling unhealthy food, to promote health diet, allows health food is less expensive, be more easy to acquisition.
World health community also requires that overweight or population of being obese are provided by Ministry of Public Health and helps further, for instance the rationally popularization of fat-reducing, Weight management project.
Obesity community of the world (WOF) official website is announced, on October 11st, 2015, as the first world obesity commemoration day, pays close attention to raising common people's consciousness, the measure of common discussion obesity controlling by holding " world's obesity day " movable attraction media.
Past antiobesity agents is divided into two kinds: prevent the medicine (lipase inhibitor) of some fat absorption and the medicine (appetite suppressant) of appetite-suppressing, as Aomei department he (lipase inhibitor) can prevent the enzyme in digestive tract the absorbent little molecule of steatolysis behaviour body in diet. The absorption of fat decreases about 30%, because indigested fat is not absorbed, body weight control can be had clear and definite effect by the energy intake of minimizing. Phentermine (appetite suppressant) is by changing 5-hydroxy tryptamine level in the brain, and then reduces appetite. It can cause excitement, and blood pressure raises, and increased heart rate, thus adding total metabolism ratio. Also have sibutramine, BUP, diazoxide, amfepramone etc. These medicines are respectively provided with side effect, and side effect relates to the heart valve that aortic valve leaks and mitral valve leaks and damages, and other more serious side effect includes short of breath, dizziness and blurred vision and death etc. Following obesity medicine: hungry palliative, down and other antipsychotic drug, hormone and leptin molecule. Awakening again despite antagonism antiobesity agents research market, it is contemplated that the solution of blockbuster formula medicine also will be difficult to, and this is mainly due at past facing challenges, namely again making doctor and patient recognize the needs of therapeutic agent safety. In view of the market challenges that these are serious, it is contemplated that drugmaker is that in vigilant side effect and the millions of worlds patient service not knowing Drug therapy benefit, by having any problem, heavy road to be walked in they attempts. But, the gate of 1,000,000,000 Yankee dollar markets not also being found knocked surely open by a kind of therapeutic agent one that can provide safely and shoulder obesity to cure.
So, comply with curative effect demand and the demand for security of obese patient's fat-reducing, diet products are developed from plant amedica, can be a long-term trend, so the research of this product has compliance requirements and natural safe meaning, have employed simultaneously " integration of edible and medicinal herbs " medical material of national regulation and defend planning commission specify can as the raw material of new resources raw material, comply with lose weight demand, there is clear and definite innovative significance and social benefit.
Summary of the invention
Goal of the invention: it is an object of the invention to provide a kind of safely and effectively, with the medical material of integration of edible and medicinal herbs and new raw-food material be primary raw material, cheap, the acceptable a kind of compositions for obese patients of people.
Technical scheme is as follows:
A kind of compositions for weight-reducing, blood fat reducing, its active component is extracted by following bulk drugs and is prepared from: Bulbus Lilii 1～5 part, Rhizoma Alpiniae Officinarum 1～5 part, the Flos Sophorae Immaturus 1～10 part, Radix Puerariae 1～10 part, 1～10 part of Poria, Thallus Laminariae (Thallus Eckloniae) 1～10 part, Herba Lophatheri 1～10 part, functional oligose 1～5 part, 1-DNJ 5～20 parts, nuciferine 5～20 parts.
The described compositions for weight-reducing, blood fat reducing, functional oligose is one or several in stachyose, Raffinose, oligofructose, oligomeric xylose, oligomeric galactose, soybean oligo saccharide, dextrinosan.
The described compositions for weight-reducing, blood fat reducing, each 1～5 part possibly together with calcium pyruvate and/or L-carnitine.
The described compositions for weight-reducing, blood fat reducing, preparation method comprises the steps:
(1) Bulbus Lilii, Rhizoma Alpiniae Officinarum, the Flos Sophorae Immaturus, Radix Puerariae, Poria, Thallus Laminariae (Thallus Eckloniae), Herba Lophatheri are taken, boiling 1～3 time, 4～8 times of amount of water respectively medical material weight, each 1～3 hour, united extraction liquid, filters, and filtrate concentrates, dry, pulverize, obtain extract one.
(2) take Folium Mori or Folium Nelumbinis, be ground into coarse powder, add 55%～95% alcohol heating reflux extract 1～3 time, 4～8 times of alcohol adding amount respectively medical material weight, each 1～3 hour, united extraction liquid, filtering, filtrate is recycled to without alcohol taste, and recovered liquid passes through cation exchange resin purification, then silica gel H purification is adopted, gained purified, through 95% alcohol crystal, obtains 1-DNJ and nuciferine respectively, dry, pulverize, obtain extract two and three.
(3) said extracted thing one, two and three is merged, add stachyose, pulverize, mix, make capsule, tablet, powder, granule, oral liquid, medicinal tea.
The described compositions for weight-reducing, blood fat reducing, preparation method comprises the steps:
(1) Bulbus Lilii, Rhizoma Alpiniae Officinarum, the Flos Sophorae Immaturus, Radix Puerariae, Poria, Thallus Laminariae (Thallus Eckloniae), Herba Lophatheri are taken, boiling 1～3 time, 4～8 times of amount of water respectively medical material weight, each 1～3 hour, united extraction liquid, filters, and filtrate concentrates, dry, pulverize, obtain extract one.
(2) take Folium Mori or Folium Nelumbinis, be ground into coarse powder, add 55%～95% alcohol heating reflux extract 1～3 time, 4～8 times of alcohol adding amount respectively medical material weight, each 1～3 hour, united extraction liquid, filtering, filtrate is recycled to without alcohol taste, and recovered liquid passes through cation exchange resin purification, then silica gel H purification is adopted, gained purified, through 95% alcohol crystal, obtains 1-DNJ and nuciferine respectively, dry, pulverize, obtain extract two and three.
(3) said extracted thing one, two and three is merged, add functional oligose, calcium pyruvate and/or L-carnitine, pulverize, mix, make capsule, tablet, powder, granule, oral liquid, medicinal tea.
The described compositions for weight-reducing, blood fat reducing is used for the application in weight-reducing, fat-reducing medicament and health product in preparation.
Beneficial effect: the new raw-food material for weight-reducing, the new compositions medical material from " integration of edible and medicinal herbs " of blood fat reducing and state approval of the present invention, mainly it is made up of Bulbus Lilii extract, Rhizoma Alpiniae Officinarum extract, Huai Goat, Radix Puerariae extract, Poria extract, Thallus Laminariae (Thallus Eckloniae) extract, Herba Lophatheri extract, functional oligose, 1-DNJ, nuciferine, calcium pyruvate and (or) L-carnitine can also be added on this basis, make the different preparation being suitable for and use. Oligosaccharide used is new raw-food material or the food additive of state approval, such as stachyose, Raffinose, oligofructose, oligomeric xylose, oligomeric galactose, soybean oligo saccharide, dextrinosan etc.
The weight-reducing of the present invention, blood fat reducing new compositions from the effective integration of edible and medicinal herbs Chinese crude drug of pure natural and new raw-food material, belong to the effect playing fat-reducing, blood fat reducing of too many levels stage construction Mutiple Targets, the effect for the treatment of both the principal and secondary aspects of a disease is played by this compositions, life-time service complies fully with economics requirement, and the effect that life-time service overweight people brings is worth and is far longer than its monetary cost paid.
Above component is made according to actual needs the preparation series such as capsule, tablet, powder, granule, oral liquid, medicinal tea, more advanced dosage form can also be made for consumer by the technology updated, reach quality controllable, in order to be effective, use safety, it is easy to produce, it is simple to transport, it is simple to the purposes such as storage.
Of the present invention for weight-reducing, the new compositions of blood fat reducing, have employed the thinking for the treatment of both the principal and secondary aspects of a disease, it is repeated for modern society's crowd characteristic prescription, in modern society, all ages and classes stratum focuses on maintenance and nourishes all very much, because health knowledge is relatively deficient, say what others say, carelessly use the diet of tonic and high heat, cause that endotrophic is superfluous, the excessive transporting of taste and tired, cause weakness of the spleen and stomach, injure the day after tomorrow of people, internal phlegm-damp can not be excreted, injure yang-energy simultaneously, plus the random life of youngster and excessive diet raw food goods, cause general YIN-excess body constitution, YIN-excess then negative and positive tool void, so a lot of weight reduction products can not play good effect now, only open YIN-excess and function of spleen and stomach regulating function, add the product of suitable lowering blood-fat and reducing weight, could really play the effect of health slimming, so this product is just built upon prescription on above innovation theory basis: Bulbus Lilii yin nourishing is calmed the nerves, regulate rule of life, nourishing lung and kidney, make raw sun in the moon, Rhizoma Alpiniae Officinarum warming stomach for dispelling cold, melts the YIN-excess of cold syndrome of the stomach, and the transportation capabilities making taste are normal, negative and positive symbiosis accomplished by above two taste medicines, and spleen invigorating of dispeling cold is monarch drug. Poria spleen invigorating, promoting diuresis to eliminate damp pathogen, mind calming, Folium Mori ascending the clear and descending the turbid, Folium Nelumbinis dampness removing, spleen invigorating, yang invigorating, Radix Puerariae yang invigorating, four Chinese medicine shares the effect playing spleen invigorating, dampness removing, yang invigorating, the turbid descending, adds the function of monarch drug, is ministerial drug altogether. Flos Sophorae Immaturus liver heat removing removing heat from blood, Thallus Laminariae (Thallus Eckloniae) hard masses softening and resolving, expectorant, diuretic, Herba Lophatheri body gently oozes to be let out, and YIN-excess, expectorant fertilizer that three taste medicines melt the medicine of the monarch and his subjects jointly are got rid of external, play assistant so as to the effect of medicine, then coordinate the effect of functional oligose regulating intestinal canal flora so that human body returns health status.
The medicine of above monarch, has ascending the clear and descending the turbid, yang invigorating invigorating spleen to remove dampness, the effect of eliminating phlegm of invigorating blood circulation, then coordinates calcium pyruvate and (or) L-carnitine, jointly plays weight-reducing, blood fat reducing, the health care of blood sugar lowering, prevention and therapeutical effect.
Detailed description of the invention
Below the technical scheme in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is only a part of embodiment of the present invention, rather than whole embodiments. Based on embodiments of the invention, all other embodiments that those of ordinary skill in the art obtain under not making creative work premise, broadly fall into protection scope of the present invention.
Embodiment 1: take Folium Mori 10kg, be ground into coarse powder, adds 95% alcohol heating reflux and extracts 1 time, 8 times of alcohol adding amount respectively medical material weight, each 3 hours, united extraction liquid, filter, filtrate is recycled to without alcohol taste, and recovered liquid passes through cation exchange resin purification, then adopts silica gel purification, gained purified is through 95% alcohol crystal, obtain 1-DNJ, dry, pulverize.
Embodiment 2: take Folium Nelumbinis 10kg, be ground into coarse powder, adds 95% alcohol heating reflux and extracts 1 time, 8 times of alcohol adding amount respectively medical material weight, each 3 hours, united extraction liquid, filter, filtrate is recycled to without alcohol taste, and recovered liquid passes through cation exchange resin purification, then adopts silica gel purification, gained purified is through 95% alcohol crystal, obtain nuciferine, dry, pulverize.
Embodiment 3: take Folium Mori 10kg, be ground into coarse powder, adds 55% alcohol heating reflux and extracts 3 times, 4 times of alcohol adding amount respectively medical material weight, each 1 hour, united extraction liquid, filter, filtrate is recycled to without alcohol taste, and recovered liquid passes through cation exchange resin purification, then adopts silica gel H purification, gained purified is through 95% alcohol crystal, obtain 1-DNJ, dry, pulverize.
Embodiment 4: take Folium Nelumbinis 10kg, be ground into coarse powder, adds 55% alcohol heating reflux and extracts 3 times, 4 times of alcohol adding amount respectively medical material weight, each 1 hour, united extraction liquid, filter, filtrate is recycled to without alcohol taste, and recovered liquid passes through cation exchange resin purification, then adopts silica gel H purification, gained purified is through 95% alcohol crystal, obtain nuciferine, dry, pulverize.
Embodiment 5. prescription: Bulbus Lilii 5 parts, Rhizoma Alpiniae Officinarum 5 parts, the Flos Sophorae Immaturus, Radix Puerariae, Poria, Thallus Laminariae (Thallus Eckloniae), each 5 parts of Herba Lophatheri, 1 part of stachyose, 1-DNJ 20 parts, nuciferine 5 parts.
Take Bulbus Lilii, Rhizoma Alpiniae Officinarum, the Flos Sophorae Immaturus, Radix Puerariae, Poria, Thallus Laminariae (Thallus Eckloniae), Herba Lophatheri, boiling 1 time, 8 times of amount of water respectively medical material weight, each 3 hours, united extraction liquid, filter, filtrate concentrates, and dry, pulverize, obtain extract, add 1-DNJ and nuciferine that above-described embodiment 1 and 2 respectively obtains, merge, add stachyose, pulverize, mix, add conventional excipient, prepare into tablet.
Embodiment 6. prescription: Bulbus Lilii 1 part, Rhizoma Alpiniae Officinarum 5 parts, the Flos Sophorae Immaturus, Radix Puerariae, Poria, Thallus Laminariae (Thallus Eckloniae), each 10 parts of Herba Lophatheri, 1 part of stachyose, 1-DNJ 5 parts, nuciferine 20 parts.
Take Bulbus Lilii, Rhizoma Alpiniae Officinarum, the Flos Sophorae Immaturus, Radix Puerariae, Poria, Thallus Laminariae (Thallus Eckloniae), Herba Lophatheri, boiling 2 times, 6 times of amount of water respectively medical material weight, each 2 hours, united extraction liquid, filter, filtrate concentrates, and dry, pulverize, obtain extract, add 1-DNJ and nuciferine that above-described embodiment 3 and 4 respectively obtains, merge, add stachyose, pulverize, mix, add conventional excipient, prepare into granule.
Embodiment 7. prescription: Bulbus Lilii 5 parts, Rhizoma Alpiniae Officinarum 1 part, the Flos Sophorae Immaturus, Radix Puerariae, Poria, Thallus Laminariae (Thallus Eckloniae), each 1 part of Herba Lophatheri, 1 part of stachyose, 1-DNJ 20 parts, nuciferine 5 parts.
Take Bulbus Lilii, Rhizoma Alpiniae Officinarum, the Flos Sophorae Immaturus, Radix Puerariae, Poria, Thallus Laminariae (Thallus Eckloniae), Herba Lophatheri, boiling 3 times, 4 times of amount of water respectively medical material weight, each 1 hour, united extraction liquid, filter, filtrate concentrates, and dry, pulverize, obtain extract, add 1-DNJ and nuciferine that above-described embodiment 1 and 2 respectively obtains, merge, add stachyose, pulverize, mix, add conventional excipient, prepare into oral liquid.
Embodiment 8. prescription: Bulbus Lilii 5 parts, Rhizoma Alpiniae Officinarum 5 parts, the Flos Sophorae Immaturus, Radix Puerariae, Poria, Thallus Laminariae (Thallus Eckloniae), each 2 parts of Herba Lophatheri, oligomeric galactose 5 parts, calcium pyruvate 1 part, 1-DNJ 20 parts, nuciferine 5 parts.
Take Bulbus Lilii, Rhizoma Alpiniae Officinarum, the Flos Sophorae Immaturus, Radix Puerariae, Poria, Thallus Laminariae (Thallus Eckloniae), Herba Lophatheri, boiling 1 time, 8 times of amount of water respectively medical material weight, each 3 hours, united extraction liquid, filter, filtrate concentrates, and dry, pulverize, obtain extract, add 1-DNJ and nuciferine that above-described embodiment 1 and 2 respectively obtains, merge, add oligomeric galactose, calcium pyruvate, pulverizes, mixes, prepare into capsule.
Embodiment 9. prescription: Bulbus Lilii 5 parts, Rhizoma Alpiniae Officinarum 5 parts, the Flos Sophorae Immaturus, Radix Puerariae, Poria, Thallus Laminariae (Thallus Eckloniae), each 2 parts of Herba Lophatheri; Oligomeric galactose 5 parts, calcium pyruvate 1 part, L-carnitine 5 parts.
Take Bulbus Lilii, Rhizoma Alpiniae Officinarum, the Flos Sophorae Immaturus, Radix Puerariae, Poria, Thallus Laminariae (Thallus Eckloniae), Herba Lophatheri, boiling 2 times, 6 times of amount of water respectively medical material weight, each 2 hours, united extraction liquid, filter, filtrate concentrates, and dry, pulverize, obtain extract, add 1-DNJ and nuciferine that above-described embodiment 3 and 4 respectively obtains, merge, add oligomeric galactose, calcium pyruvate, L-carnitine, pulverize, mix, prepare into capsule.
Embodiment 10. prescription: Bulbus Lilii 5 parts, Rhizoma Alpiniae Officinarum 5 parts, the Flos Sophorae Immaturus, Radix Puerariae, Poria, Thallus Laminariae (Thallus Eckloniae), each 2 parts of Herba Lophatheri, oligomeric galactose 5 parts, L-carnitine 1 part.
Take Bulbus Lilii, Rhizoma Alpiniae Officinarum, the Flos Sophorae Immaturus, Radix Puerariae, Poria, Thallus Laminariae (Thallus Eckloniae), Herba Lophatheri, boiling 3 times, 4 times of amount of water respectively medical material weight, each 1 hour, united extraction liquid, filter, filtrate concentrates, and dry, pulverize, obtain extract, add 1-DNJ and nuciferine that above-described embodiment 3 and 4 respectively obtains, merge, add oligomeric galactose, L-carnitine, pulverizes, mixes, prepare into capsule.
Embodiment 11. prescription: Bulbus Lilii 5 parts, Rhizoma Alpiniae Officinarum 5 parts, the Flos Sophorae Immaturus, Radix Puerariae, Poria, Thallus Laminariae (Thallus Eckloniae), each 2 parts of Herba Lophatheri, oligomeric galactose 5 parts, L-carnitine 5 parts.
Take Bulbus Lilii, Rhizoma Alpiniae Officinarum, the Flos Sophorae Immaturus, Radix Puerariae, Poria, Thallus Laminariae (Thallus Eckloniae), Herba Lophatheri, boiling 3 times, 4 times of amount of water respectively medical material weight, each 1 hour, united extraction liquid, filter, filtrate concentrates, and dry, pulverize, obtain extract, add 1-DNJ and nuciferine that above-described embodiment 3 and 4 respectively obtains, merge, add oligomeric galactose, L-carnitine, pulverizes, mixes, prepare into capsule.
Embodiment 12. present invention loses weight, the pharmacological action of blood fat reducing
Experimentation: take sample prepared by above-described embodiment 5 method as test medication, take SD rat 50, it is divided into 5 groups, often group 10, respectively blank group, high fat group, medication group (high, medium and low), high, medium and low dose is 16g/kg, 8g/kg, 4g/kg, amount is grouped after terminating respectively, control rats continues to give normal feedstuff and freely ingests every day, what other rats in test groups gave high lipid food in sky starts simultaneously at administration, the distilled water of high fat group rat oral gavage equivalent, the continuous gavage of each group 30 days.
When experiment terminates, rat puts to death front fasting 12 hours, do not cut off the water supply, measuring its body weight, then disconnected neck puts to death rat, takes blood, after room temperature stands, low-temperature centrifugation (3000r/min) lOmin, taking serum, to be placed in-20 DEG C of refrigerators to be checked, adopts test kit enzymic colorimetric to measure serum total cholesterol (TC), total TG (TG), HDL-C (HDL-C) after blood treatment.
Research shows, rat body weight is had obvious intervention effect by this compositions, hence it is evident that lose weight; Rat TC, TG there are is obvious intervention effect, HDL-C is had rising effect. Result is in Table 1-2.
The table 1 impact on rat body weight
Note: test group compares * P < 0.05, * * P < 0.01 with blank group; Test group compares #P < 0.05, ##P < 0.01 with model group.
The table 2 impact on rat fat
Note: test group compares * P < 0.05, * * P < 0.01 with high fat group.
Combinations of the above thing has effect of weight-reducing, blood fat reducing, so body weight control is had effect by this compositions, it is possible to reduce the generation of obesity.
Embodiment 13. present invention loses weight, the pharmacological action of blood fat reducing
Experimentation: take sample prepared by above-described embodiment 9 method as test medication, take SD rat 50, it is divided into 5 groups, often group 10, respectively blank group, high fat group, medication group (high, medium and low), high, medium and low dose is 16g/kg, 8g/kg, 4g/kg, after packet terminates, control rats continues to give normal feedstuff and freely ingests every day, what other rats in test groups gave high lipid food in sky starts simultaneously at administration, the distilled water of high fat group rat oral gavage equivalent, the continuous gavage of each group 30 days.
When experiment terminates, rat puts to death front fasting 12 hours, do not cut off the water supply, measuring its body weight, then disconnected neck puts to death rat, takes blood, after room temperature stands, low-temperature centrifugation (3000r/min) lOmin, taking serum, to be placed in-20 DEG C of refrigerators to be checked, adopts test kit enzymic colorimetric to measure serum total cholesterol (TC), total TG (TG), HDL-C (HDL-C) after blood treatment.
Research shows, rat body weight is had obvious intervention effect by this compositions, hence it is evident that lose weight; Rat TC, TG there are is obvious intervention effect, HDL-C is had rising effect. Result is in Table 3-4.
The table 3 impact on rat body weight
Note: test group compares * P < 0.05, * * P < 0.01 with blank group; Test group compares #P < 0.05, ##P < 0.01 with model group.
The table 4 impact on rat fat
Note: test group compares * P < 0.05, * * P < 0.01 with high fat group.
Combinations of the above thing has effect of weight-reducing, blood fat reducing, so body weight control is had effect by this compositions, it is possible to reduce the generation of obesity.
This compositions and similar condition ratio, raw material chemicals of the present invention is of fine quality to be easy to get, determined curative effect, have simplicity, efficiently, safety, and less costly, simple to operate, replicability strong, application prospect advantage widely.
The above; being only the present invention preferably detailed description of the invention, but protection scope of the present invention is not limited thereto, any those familiar with the art is in the technical scope of present disclosure; the change that can readily occur in or replacement, all should be encompassed within protection scope of the present invention. Therefore, protection scope of the present invention should be as the criterion with the protection domain of claims.

Claims (6)

1. the compositions for weight-reducing, blood fat reducing, it is characterised in that: its active component is extracted by following bulk drugs and is prepared from: Bulbus Lilii 1～5 part, Rhizoma Alpiniae Officinarum 1～5 part, the Flos Sophorae Immaturus 1～10 part, Radix Puerariae 1～10 part, 1～10 part of Poria, Thallus Laminariae (Thallus Eckloniae) 1～10 part, Herba Lophatheri 1～10 part, functional oligose 1～5 part, 1-DNJ 5～20 parts, nuciferine 5～20 parts.
2. according to claim 1 for the compositions of weight-reducing, blood fat reducing, it is characterised in that: functional oligose is one or several in stachyose, Raffinose, oligofructose, oligomeric xylose, oligomeric galactose, soybean oligo saccharide, dextrinosan.
3. according to claim 1 for the compositions of weight-reducing, blood fat reducing, it is characterised in that: each 1～5 part possibly together with calcium pyruvate and/or L-carnitine.
4. according to claim 1 for the compositions of weight-reducing, blood fat reducing, it is characterised in that: preparation method comprises the steps:
(1) Bulbus Lilii, Rhizoma Alpiniae Officinarum, the Flos Sophorae Immaturus, Radix Puerariae, Poria, Thallus Laminariae (Thallus Eckloniae), Herba Lophatheri are taken, boiling 1～3 time, 4～8 times of amount of water respectively medical material weight, each 1～3 hour, united extraction liquid, filters, and filtrate concentrates, dry, pulverize, obtain extract one.
(2) take Folium Mori or Folium Nelumbinis, be ground into coarse powder, add 55%～95% alcohol heating reflux extract 1～3 time, 4～8 times of alcohol adding amount respectively medical material weight, each 1～3 hour, united extraction liquid, filtering, filtrate is recycled to without alcohol taste, and recovered liquid passes through cation exchange resin purification, then silica gel H purification is adopted, gained purified, through 95% alcohol crystal, obtains 1-DNJ and nuciferine respectively, dry, pulverize, obtain extract two and three.
(3) said extracted thing one, two and three is merged, add functional oligose, pulverize, mix, make capsule, tablet, powder, granule, oral liquid, medicinal tea.
5. according to claim 3 for the compositions of weight-reducing, blood fat reducing, it is characterised in that: preparation method comprises the steps:
(1) Bulbus Lilii, Rhizoma Alpiniae Officinarum, the Flos Sophorae Immaturus, Radix Puerariae, Poria, Thallus Laminariae (Thallus Eckloniae), Herba Lophatheri are taken, boiling 1～3 time, 4～8 times of amount of water respectively medical material weight, each 1～3 hour, united extraction liquid, filters, and filtrate concentrates, dry, pulverize, obtain extract one.
(2) take Folium Mori or Folium Nelumbinis, be ground into coarse powder, add 55%～95% alcohol heating reflux extract 1～3 time, 4～8 times of alcohol adding amount respectively medical material weight, each 1～3 hour, united extraction liquid, filtering, filtrate is recycled to without alcohol taste, and recovered liquid passes through cation exchange resin purification, then silica gel H purification is adopted, gained purified, through 95% alcohol crystal, obtains 1-DNJ and nuciferine respectively, dry, pulverize, obtain extract two and three.
(3) said extracted thing one, two and three is merged, add stachyose, calcium pyruvate and/or L-carnitine, pulverize, mix, make capsule, tablet, powder, granule, oral liquid, medicinal tea.
6. the compositions for weight-reducing, blood fat reducing according to claim 1 is used for the application in weight-reducing, fat-reducing medicament and health product in preparation.
CN201610128292.6A 2016-03-07 2016-03-07 Composition used for slimming and reducing lipid Withdrawn CN105663966A (en)

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CN109770145A (en) * 2019-01-03 2019-05-21 西安源森生物科技有限公司 A kind of auxiliary improves the solid beverage and preparation method thereof of disorders of lipid metabolism
CN112043683A (en) * 2020-08-06 2020-12-08 中国计量大学 Preparation method of lipid-lowering/weight-reducing compound hydrogel
CN114521601A (en) * 2021-12-30 2022-05-24 海南三风友制药有限公司 Beverage composition for losing weight and reducing fat and preparation method thereof

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CN109770145A (en) * 2019-01-03 2019-05-21 西安源森生物科技有限公司 A kind of auxiliary improves the solid beverage and preparation method thereof of disorders of lipid metabolism
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