CN105663900A - Medicated food for improving nutrition state of liver cirrhosis - Google Patents
Medicated food for improving nutrition state of liver cirrhosis Download PDFInfo
- Publication number
- CN105663900A CN105663900A CN201610128556.8A CN201610128556A CN105663900A CN 105663900 A CN105663900 A CN 105663900A CN 201610128556 A CN201610128556 A CN 201610128556A CN 105663900 A CN105663900 A CN 105663900A
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- China
- Prior art keywords
- liver
- parts
- liver cirrhosis
- poria
- endothelium corneum
- Prior art date
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Landscapes
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Abstract
The invention provides a medicated food for improving the nutrition state of liver cirrhosis, which is prepared from the following raw materials: tuckahoe, coix seed, Chinese yam, finger citron, endothelium corneum gigeriae galli, jujubes and ordinary rice; and the raw materials have the effects of strengthening the spleen and eliminating dampness as well as soothing the liver and regulating the flow of qi. By virtue of the characteristics of foods according to the homology of medicines and foods, the medicated food can supply partial energy and nutritional ingredients required by patient bodies; and moreover, by virtue of the effects of the traditional Chinese medicine components for strengthening the spleen and eliminating dampness as well as promoting qi circulation for diuresis, the functions of tri-jiao for promoting qi circulation, dredging collaterals and promoting diuresis are optimal, so that pathological factors are eliminated, the physiological functions of the liver are improved, physiologic conditions favorable for repairing liver tissues are formed, and a benign auxiliary treatment effect on the condition of a patient suffering liver cirrhosis is achieved. The medicated food has the effects of increasing plasma albumin, promoting liver regeneration and promoting recovery of liver functions. The invention provides a new simple, feasible, economical, practical, safe and effective method for auxiliary treatment of the patient suffering liver cirrhosis in the decompensated period. Through clinical practice for many years, the effective rate of the medicated food is 92.7%.
Description
Technical field:
The present invention relates to integration of edible and medicinal herbs field of food, particularly a kind of medicated diet for improving liver cirrhosis nutritional status, it is possible to significantly improve patient and aoxidize energy supply ratio, improve Proteometabolism, improve albumin level.
Background technology:
Liver cirrhosis is Diffuse fibrous hamartoplasia and the regeneration of liver cell nodules shape, and liver normal configuration is destroyed, so that causing the clinical symptoms being main manifestations with hypofunction of liver and portal hypertension. EASL (EASL) points out in guide for 2012, untreated chronic hepatitis B (CHB) patient, within 5 years, accumulative liver cirrhosis incidence rate is 8%～20%, 5 years accumulative decompensated liver cirrhosis incidence rates about 20% of Decompensated cirrhosis patient, and being in progress is Decompensated Cirrhosis Patients, if untreated, then its 5 years survival rates are only 14%～35%, and in liver cirrhosis patient, annual primary hepatoma (HCC) incidence rate is 2%～5%. One of country that China is whole world pathogenesis of cirrhosis rate, mortality rate is the highest. Liver cirrhosis patient Relapse rate, protracted course of disease, lose compensatory after may occur in which various complication, have a strong impact on its quality of life, cause great pressure to patients ' psychological. Seriously threaten life and the life quality of patient. Thus effectively improve cirrhosis patients in decompensation patient's nutritional status, reduce complication for patients, improve life quality, improve Clinical Outcome and prognosis, be one of key problem clinical urgently to be resolved hurrily at present.
Liver cirrhosis patient all has malnutrition in various degree, and the reason of its Risk of malnutrition mainly has absorption to reduce; Disorder of Digestion and Absorption; Consume and increase; Synthesis deficiency waits and irrational meals make malnutrition become apparent from, and burden of liver can be increased, reduce the hepatocyte resistance to paathogenic factor, make liver function go down further, cause that sb.'s illness took a turn for the worse. End-stage liver disease (ESLD) patients such as big quantity research shows, many liver cirrhosis not die from hepatopathy itself, but die from the complication such as malnutrition and the refractory ascites thus caused, repeated infection, liver regeneration be bad. Liver is the maincenter organ of many substance metabolismes such as sugar, fat, protein, and liver cirrhosis necessarily causes liver metabolism function reduction thus having influence on overall health of patients. Research shows, liver cirrhosis patient exists obvious Developmental and Metabolic Disorder, and fasting one is easy to cause body to utilize aminoacid to realize glyconeogenesis night. Owing to hepatocyte quantity is not enough with synthesis capability, liver glycogen reserves degradation, therefore the aminoacid of skeletal muscle is mobilized increases, and to meet the body needs to glucose, this change is equivalent in normal person's fasting situation of three days.
Separately there is research display, give liver cirrhosis patient snack at night (lateeveningsnack, LES), it is possible to significantly improve patient and aoxidize energy supply ratio, improve Proteometabolism, improve albumin level.It is now recognized that night, snack content should based on carbohydrate, snack branched-amino acid supplement also can improve serum protein levels, but owing to mouthfeel is poor, patient compliance can decrease. Niu Wa?(Noveliver?) it is the many kinds of substances such as a kind of NEW TYPE OF COMPOSITE nutrient for hepatopath's design, rich in proteins, aminoacid, vitamin, trace element, folic acid, organic selenium. Early-stage Study shows, gives rats with liver cirrhosis knob baby?Liver nutrient is intervened, it is possible to comparatively fast promotes albumin level, improves fibrosis. But knob baby's somewhat expensive, major part patient burden do not rise.
Liver cirrhosis belongs to the traditional Chinese medical science " tympanites " " the liver rump " " jaundice " category, for one of " wind, consumptive disease, distension, diaphragm " four disaster disease. Due to patient's pathological changes with the passing of time, positive QI-insufficiency, stagnant in the domination of pathogen, often coldheat complex, deficiency and excess has concurrently, so treatment is very thorny. It is generally acknowledged that this onset of disease is that epidemic disease caused by damp-heat pathogen poison accumulates in resistance burnt, the liver failing to maintain the normal flow of QI, qi depression to blood stasis, and then perverse and unreasonable manner take advantage of spleen, dysfunction of the spleen in transportation. Liver spleen has close contact on physiology. Spleen soil is placed in the middle burnt, and for the hinge of ascending or descending movement of vital Qi, source of generating QI and blood, main transporting and transforming nutrients from foodstuff is precise and tiny; The spleen is in charge of sending up essential substances, helps the catharsis of liver; The stomach being liable to sending digested food downward, is beneficial to bile excretion. On physiology, the normal transporting of taste and elevating function depend on the catharsis of irritability, and the catharsis function of liver is normal, QI movement being in harmonious way, then taste lifting is in order, and transportation capabilities perfect. Meanwhile, The spleen and stomach provide the material basis of the acquired, source of generating QI and blood, and the strong fortune of temper is then biochemical active, and liver blood fills Sheng. On pathology, the splenopathy can affect in liver, deficiency of spleen-QI, no resource of generating and transforming QI and blood, or failure of the spleen to keep the blood flowing within the vessels, severe loss of blood, can involve in liver, form deficiency of liver-blood. Dysfunction of the spleen in transportation, retention of water-damp in the body, with the passing of time accumulates long-pending raw heat, damp and hot accumulates steaming, make suffocating of liver and gall unfavorable, can form jaundice. Otherwise, hepatopathy also affects in spleen, the liver failing to maintain the normal flow of QI, causes soil and stops up wooden strongly fragrant, forms the syndrome of disharmony between the liver and spleen or incoordination between the liver and stomach. As can be seen here, the splenopathy passes liver, hepatopathy and spleen, and liver spleen two is dirty to influence each other on pathology. Deficiency in origin and excess in superficiality, simulataneous insufficiency and excessive is to form the basic pathogenesis of cirrhosis patients in decompensation, is mainly insufficiency of the spleen mistake and transports. Deficiency in origin is deficiency of spleen-QI, deficiency of liver-YIN, deficiency of the kidney yin, and mark is real is the stagnation of QI, blood stasis, water retention, disease located in liver, in close relations with spleen, kidney. First the disease being located in the liver, shows as dampness-heat in the liver and gallbladder more, for a long time then stagnation of liver-QI with deficiency of the spleen, spleen asthenia and dampness retention, and water is wet to be pented up, the kidney usually involved in chronic disease, liver and kidney deficiency, and insufficiency of the spleen is that cirrhosis patients in decompensation develops important step.
Summary of the invention
In sum, the purpose of the present invention is just to provide a kind of medicated diet for improving liver cirrhosis nutritional status, invents the change along with medical model, and people, while pursuing clinical efficacy, more focus on the thought of " integration of edible and medicinal herbs, Diet cures more than the doctors ". Ancients have the viewpoint of " doctor's food homology " " residence is cured in food ", and Li Shizhen (1518-1593 A.D.) describes the curative effect of more than 300 kind of conventional food in Compendium of Material Medica, and proposes multiple food therapy side. The dietary therapy of Chinese medicine had both been different from pharmacotherapy, also had difference with full diet, and it utilizes the characteristic that food nature and flavor are biased, targetedly for the treatment of some disease or auxiliary treatment, adjust the physiological function of intracorporeal organ tissue, so as to tend to balance, contribute to the treatment of disease and the rehabilitation of body and mind. Well-known doctor's Zhang Xichun is said: " disease is not only treated in dietetic therapy, and can allay one's hunger, and not only allays one's hunger, more can be agreeable to the taste, with suiting the medicine to the illness, sick from gradually healing."
The technical scheme is that and be accomplished by:
A kind of medicated diet for improving liver cirrhosis nutritional status, is that Fructus Jujubae 3-7, Semen oryzae sativae 2-8 part is made by Poria 5-15 part by weight, Rhizoma Dioscoreae 5-15 part, Semen Coicis 5-15 part, Fructus Citri Sarcodactylis 5-15 part, Endothelium Corneum Gigeriae Galli 1-6 part; The processing method of described medicated diet comprises the following steps:
1) raw material Poria is chosen by formula, Rhizoma Dioscoreae, Semen Coicis, Fructus Citri Sarcodactylis, Endothelium Corneum Gigeriae Galli, Fructus Jujubae, Semen oryzae sativae, through drying after Removing Kernel for Date, standby;
2) the raw material pulverizer of step 1) is processed into powder;
3) before sleeping half an hour or evening 9-10 point, by step 2) the powder boiled water furnishing 150-200ml rice processed sticks with paste and drinks;
4) snack at night should continue 3 months.
Further, described a kind of medicated diet for improving liver cirrhosis nutritional status, is that Fructus Jujubae 4-5, Semen oryzae sativae 3-5 part is made by Poria 7-10 part by weight, Rhizoma Dioscoreae 7-10 part, Semen Coicis 7-10 part, Fructus Citri Sarcodactylis 7-10 part, Endothelium Corneum Gigeriae Galli 3-5 part.
Further, described a kind of medicated diet for improving liver cirrhosis nutritional status, is that Fructus Jujubae 4-5, Semen oryzae sativae 4-6 part is made by Poria 12-13 part by weight, Rhizoma Dioscoreae 12-13 part, Semen Coicis 12-13 part, Fructus Citri Sarcodactylis 12-13 part, Endothelium Corneum Gigeriae Galli 2-4 part.
Further, described a kind of medicated diet for improving liver cirrhosis nutritional status, is that Semen oryzae sativae 7 parts is made by 8 parts of Poria by weight, Rhizoma Dioscoreae 8 parts, Semen Coicis 8 parts, Fructus Citri Sarcodactylis 8 parts, Endothelium Corneum Gigeriae Galli 4 parts, 6, Fructus Jujubae.
Further, described a kind of medicated diet for improving liver cirrhosis nutritional status, is that Semen oryzae sativae 4 parts is made by 14 parts of Poria by weight, Rhizoma Dioscoreae 14 parts, Semen Coicis 14 parts, Fructus Citri Sarcodactylis 14 parts, Endothelium Corneum Gigeriae Galli 3 parts, 4, Fructus Jujubae.
The pharmacology of the present invention is according to being:
Poria is sweet, light, flat; Enter the heart, spleen, kidney channel, there is eliminating dampness by diuresis diuresis, stomach function regulating spleen invigorating, mind tranquilizing and the heart calming, antibacterial, enhancing body resistance against diseases and drop hypoglycemic effect;
Rhizoma Dioscoreae nature and flavor are sweet, flat, enter lung, spleen, kidney channel, have spleen reinforcing nourishing the stomach, effect of the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission; Rhizoma Dioscoreae is tonification Chinese medicine simply, is again daily good vegetables, is classified as " top grade " medical material in Shennong's Herbal, it is believed that its " invigorating the spleen and replenishing QI power, longue meat take normal hearing and eyesight for a long time, makes light of one's life by commiting suicide, not hungry prolong life "; Trophic analysis shows, the multiple nutritional components such as Rhizoma Dioscoreae rich in starch, protein, aminoacid, vitamin, the digestive enzyme contained by Rhizoma Dioscoreae can promote the decomposition of protein and starch, is conducive to digesting and assimilating of food. Dehydroepiandrosterone contained by Rhizoma Dioscoreae, has special health-care effect to human body, has effect of prevention of arterial hardening and obesity;
Its cold nature of Semen Coicis, sweet in the mouth, light, return spleen, stomach, lung meridian; There are spleen invigorating eliminating dampness by diuresis, effect of eliminating impediment antidiarrheal; In modern pharmacology research, the main active of Semen Coicis includes saccharide, esters, unsaturated fatty acids and lactams etc., has antitumor, improves many-sided effects such as immunity of organisms, blood sugar lowering, anti-inflammatory and antalgic; Mild in medicine property and, food medicine take into account, in clinic, health preserving etc., all occupy critical positions;
Fructus Citri Sarcodactylis is warm in nature, acrid in the mouth, bitter, sour; Enter liver, spleen, lung meridian; There is effect of depressed liver-energy dispersing and QI regulating and stomach and alleviating pain; Research finds, Fructus Citri Sarcodactylis has immunomodulating, antioxidation and promotes gastrointestinal peristalsis effect;
Endothelium Corneum Gigeriae Galli is containing gastric hormone, keratin, trace pepsin, amylase and several amino acids, have effect of strengthening the spleen to promote digestion, and Endothelium Corneum Gigeriae Galli is as class aid digestion in stomach medicine and strengthens gastric motility class medicine, have a extensive future, and Endothelium Corneum Gigeriae Galli is the natural material of integration of edible and medicinal herbs, nontoxic, develop into natural health care, medicated diet, prescription application all can play its bigger medical value;
Fructus Jujubae sweet in the mouth warm in nature, returns spleen, stomach warp;Invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind, relaxes the property of medicine; The further pharmacological research of Fructus Jujubae shows, jujube polysaccharide has effect of obvious promoting the circulation of blood, hemostasis, diuretic, dredge the meridian passage, has obvious anticomplementary activity simultaneously and promotes lymphopoietic effect, and it can effective enhancing human body immunity power. Jujube pulp polysaccharide can strengthen mouse humoral immune and cellular immune function, and radiation injury has certain protective effect, is immunostimulant; Research confirms, jujube polysaccharide has the physiologically actives such as anticancer and anti-AIDS, and its medical value receives much attention;
Semen oryzae sativae is firmly few viscous, and abnormal smells from the patient is bitter, sweet, flat, nontoxic, enters spleen, stomach warp; There is people's cloud Song dynasty: Semen oryzae sativae with evening rice for first ... gentle the five internal organs, tonification gastric qi, its merit is not captured; The Tang Dynasty medicine scholar Sun Si ease is emphasized in " prescriptions worth thousand gold dietetic therapy ", Semen oryzae sativae energy nourishing the stomach gas, longue meat; " food mirror book on Chinese herbal medicine " is it also holds that Semen oryzae sativae has tonifying the spleen and stomach, supports the five internal organs, strengthens the good effects of strength. Semen oryzae sativae is the staple food of the south China people, and containing a large amount of carbohydrates, accounting for 79% is the main source of heat; Although the protein in Semen oryzae sativae only accounts for 7%, but because the amount of eating is very big, so remaining the important sources of protein; Essential amino acid contained by Semen oryzae sativae is also relatively more comprehensive, possibly together with multiple nutritional components such as fat, calcium, phosphorus, ferrum and vitamin B group.
The present invention is through clinical practice for many years, finding that Chinese medicine based on spleen invigorating can effectively improve the trophic level of patient, Chinese medicine used is mainly Poria, Semen Coicis, Rhizoma Dioscoreae, Fructus Citri Sarcodactylis, Endothelium Corneum Gigeriae Galli, Fructus Jujubae, Semen oryzae sativae have the merit of invigorating the spleen to clear away damp pathogen, depressed liver-energy dispersing and QI regulating. Integration of edible and medicinal herbs is by means of the characteristic of food itself, portion of energy and the nutritional labeling of body requirement can not only be provided for patient, and by the invigorating the spleen to clear away damp pathogen of Chinese medicine ingredients, promoting the circulation of QI to induce diuresis effect, make the current vigour of three Jiao, unclog the channel, run water paddy function and reach the best, thus eliminating pathological factor, improve the physiological function of liver, it is formed and is beneficial to the physiological condition that liver organization is repaired, the condition of liver cirrhosis patient is created optimum auxiliary therapeutic action (P < 0.05). Three burnt current three gas, go through all internal organs, three burnt logical hundred arteries and veins, its in season the period of the day from 9 p.m. to 11 p.m-period of the day from 3 am to 5 am (21:00-23:00 at night), be human body cell rehabilitation during this period of time, time of weeding out the old and bring forth the new; The period of the day from 11 p.m. to 1 a.m-period of the day from 1 a.m. to 3 a.m. (23:00-3:00 AM at night) is that liver and gall are through time in season, liver storing blood, main catharsis, the blood flows back to the liver when the man lies down. Liver cirrhosis patient snack at night is then more conducive to human nutrition material absorbing, provides raw material for hepatocyte reparative regeneration. " your outline golden " cloud: " seeing the disease of liver, knowing the liver disease will be transmitted into the spleen, in the ban tonifying the spleen ", highlights the theory of preventive treatment of disease and preventing exacerbation after being taken ill. " having one point of gastric qi, then have a mitogenetic machine ", in liver cirrhosis patient treatment, spleen invigorating turns round and look at that to protect gastric qi particularly important. Ancient literature is excavated by novelty, in conjunction with hepatopathy section own characteristic, theoretical based on hepatopathy tonifying the spleen, use the integration of edible and medicinal herbs intervention study to liver cirrhosis patient nutritional status, quality of life, by observing patients symptomatic, Body Mass Index (BMI), triceps skinfold thickness (TSF), arm muscle circumference (MAMC), the nutritional status such as grip inspection and complication reduce. Finding in long-term clinical observation, under " integration of edible and medicinal herbs " theoretical direction, liver cirrhosis patient snack at night, quality of life is improved, and the method is simple and easy to do, expense is low, patient is prone to accept.
The invention has the beneficial effects as follows:
Cirrhosis patients in decompensation patient is adopted " integration of edible and medicinal herbs " by the present invention, observe the impact on cirrhosis patients in decompensation patient's nutritional status, liver function and life quality, for improving the medicated diet of liver cirrhosis nutritional status, plasma albumin can be improved, promote the effect of the recovery aspect of liver regeneration and liver function, provide a kind of simple, economical and practical, safely and effectively new method for the auxiliary treatment of cirrhosis patients in decompensation patient. The present invention is through clinical practice for many years, and its effective percentage is 92.7%.
Detailed description of the invention:
Below in conjunction with embodiment, the present invention is described in further detail.
Embodiment 1
A kind of medicated diet for improving liver cirrhosis nutritional status, is that Fructus Jujubae 3-7, Semen oryzae sativae 2-8 part is made by Poria 5-15 part by weight, Rhizoma Dioscoreae 5-15 part, Semen Coicis 5-15 part, Fructus Citri Sarcodactylis 5-15 part, Endothelium Corneum Gigeriae Galli 1-6 part; The processing method of described medicated diet comprises the following steps:
1) raw material Poria is chosen by formula, Rhizoma Dioscoreae, Semen Coicis, Fructus Citri Sarcodactylis, Endothelium Corneum Gigeriae Galli, Fructus Jujubae, Semen oryzae sativae, through drying after Removing Kernel for Date, standby;
2) the raw material pulverizer of step 1) is processed into powder;
3) before sleeping half an hour or evening 9-10 point, by step 2) the powder boiled water furnishing 150-200ml rice processed sticks with paste and drinks;
4) snack at night should continue 3 months.
Embodiment 2
A kind of medicated diet for improving liver cirrhosis nutritional status, is that Fructus Jujubae 4-5, Semen oryzae sativae 3-5 part is made by Poria 7-10 part by weight, Rhizoma Dioscoreae 7-10 part, Semen Coicis 7-10 part, Fructus Citri Sarcodactylis 7-10 part, Endothelium Corneum Gigeriae Galli 3-5 part; The processing method of described medicated diet is with embodiment 1.
Embodiment 3
A kind of medicated diet for improving liver cirrhosis nutritional status, is that Fructus Jujubae 4-5, Semen oryzae sativae 4-6 part is made by Poria 12-13 part by weight, Rhizoma Dioscoreae 12-13 part, Semen Coicis 12-13 part, Fructus Citri Sarcodactylis 12-13 part, Endothelium Corneum Gigeriae Galli 2-4 part; The processing method of described medicated diet is with embodiment 1.
Embodiment 4
A kind of medicated diet for improving liver cirrhosis nutritional status, is that Semen oryzae sativae 7 parts is made by 8 parts of Poria by weight, Rhizoma Dioscoreae 8 parts, Semen Coicis 8 parts, Fructus Citri Sarcodactylis 8 parts, Endothelium Corneum Gigeriae Galli 4 parts, 6, Fructus Jujubae; The processing method of described medicated diet is with embodiment 1.
Embodiment 5
A kind of medicated diet for improving liver cirrhosis nutritional status, it is characterised in that 14 parts of Poria by weight, Rhizoma Dioscoreae 14 parts, Semen Coicis 14 parts, Fructus Citri Sarcodactylis 14 parts, Endothelium Corneum Gigeriae Galli 3 parts, 4, Fructus Jujubae, Semen oryzae sativae 4 parts is made; The processing method of described medicated diet is with embodiment 1.
The present invention is applied to clinic and receives good effect, and total effective rate is 92.7%; Concrete clinical data is as follows:
One. diagnostic criteria
Cirrhosis patients in decompensation patient is adopted " integration of edible and medicinal herbs " novel LES by this research, observe the impact on cirrhosis patients in decompensation patient's nutritional status, liver function and life quality, study novel LES and improve nutritional status, improve plasma albumin, promote the effect of the recovery aspect of liver regeneration and liver function, explore simple, economical and practical, safely and effectively new method for the auxiliary treatment of cirrhosis patients in decompensation patient.
Choose and meet in JIUYUE, 2012 Chinese Medical Association infectious disease and parasitic disease credit meeting in December, 2015 in January, 2014, hepatopathy credit can combine in revision " viral hepatitis control prece " about cirrhosis patients in decompensation inpatient 110 example, adopt district's group method of randomization, patient is divided into two groups, often organize 55 examples, LES seminar is " the novel LES of Primary Care+integration of edible and medicinal herbs ", matched group is " Primary Care ", 2 weeks courses for the treatment of, follow up a case by regular visits to 3 months, respectively from nutritionally relevant scoring, Child-Pugh marks, liver function, anthropometry's index, chronic hepatopathy life quality, the aspects such as complication rate, evaluate the integration of edible and medicinal herbs novel LES curative effect to cirrhosis patients in decompensation patient's nutritional status.
1. object of study
1.1 doctor trained in Western medicine liver cirrhosis diagnosis standards
Case can combine the diagnostic criteria about liver cirrhosis in revision " viral hepatitis control prece " with reference in JIUYUE, 2012 Chinese Medical Association infectious disease with parasitic disease credit meeting, hepatopathy credit, for getting rid of other causes of disease and the treatment impact on clinical efficacy, hbv-liver cirrhosis Decompensated stage patient is only included in this research in.
1.2 TCM syndrome diagnostic criterias
With reference to the 15th seminar of digestive system disease Professional Committee of CAIM (Chinese Association Of Integrative Medicine) held in Taiyuan for 2011, the differentiation of symptoms and signs for classification of syndrome that " the liver cirrhosis combination of Chinese and Western medicine diagnosis and treatment common recognition " formulated is discussed is standard, possess primary symptom and secondary disease more than one, in conjunction with picture of the tongue, pulse condition, namely diagnosable.
The calculating of 1.3 sample sizes
According to the appointment requirement of statistics smallest sample amount, each treatment group sample number is 50 examples, it is considered to the depigmentation rate of 10%, and often group needs sample 55 example, amounts to 110 examples, LES seminar 55 example, matched group 55 example.
2. research method
2.1 EXPERIMENTAL DESIGN types: random, controlled trial design.
2.1.1 random: to adopt district's group method of randomization. By SAS statistical analysis system PROCPLAN procedure statement, given seed number, produce 110 example random number.
2.1.2 establishing criteria, adopts random packet, according to the priority of patient's order in hospital, patient divides two groups, and LES seminar is adopted as " the novel LES of Primary Care+integration of edible and medicinal herbs ", and matched group adopts " Primary Care ".
Primary Care: the liver protecting and ALT lowering etc. are treated, and two groups all carry out according to section office's conventional treatment; Nucleoside (acid) analog antiviral therapy is given to meeting the patient of liver cirrhosis antiviral indication in 2010 version " the guideline ". There is antiviral indication, but the patient being unwilling maybe can not accept antiviral therapy exits research.
3. observation index
3.1 biological indicator general datas: experimenter's name, test start date, address, telephone number, name.
Biological indicator (1) demographic data: include sex, age, height, body weight, nationality etc.; (2) vital sign: body temperature, heart rate, breathing, blood pressure, abnormal symptom sign etc., tells in situation record at any time if any exception or spy.
3.2 health giving quality indexs
Reference " new Chinese medicine guideline of clinical investigations " (Zheng Xiao cornel. new Chinese medicine guideline of clinical investigations ［ M ］. Beijing: China Medical Science Press, 2002:143-151) formulate such as table 1 below:
Table 1
3.2.3 therapeutic effect of syndrome evaluation
All symptoms be all divided into without, light, in, weight level Four, remember 0,2,4,6 respectively in primary symptom, then remember 0,1,2,3 points respectively at secondary card. Normal and improper two-stage is then divided into for tongue arteries and veins, remembers 0,2 points respectively in primary symptom, remember 0,1 point respectively secondary disease. The computational methods of therapeutic effect of syndrome criterion, with reference to " new Chinese medicine guideline of clinical investigations " efficacy assessment standard, adopt nimodipine method to calculate. Therapeutic index (%)=[before (before treatment integration after integration one treatment)/treatment integration] x100%.
3.2.3.1 clinical remission: sings and symptoms is obviously improved (therapeutic index >=95%);
3.2.3.2 effective: sings and symptoms is obviously improved (70%≤therapeutic index < 95%);
3.2.3.3 effective: sings and symptoms has improvement (30%≤therapeutic index < 70%);
3.2.3.4 invalid: sings and symptoms is without substantially alleviating or adding severe one (therapeutic index < 30%).
SPSS19.0 software is adopted to carry out statistical procedures.All measurement data data all represent with mean ± standard deviation, and measurement data adopts variance analysis, and enumeration data adopts X 2 test or rank test, and P < 0.05 is by statistically significant for the difference being considered to check.
Result is in Table 2
Table 2 observation group compares with matched group total effective rate
| Group | Number of cases | Effective | Effectively | Invalid | Effective percentage % |
| Observation group | 55 | 42 | 9 | 4 | 92.7 |
| Matched group | 55 | 31 | 6 | 8 | 69.1 |
Untoward reaction: all cases do not find obvious untoward reaction.
Model case
1. Lv, man, taxi driver, 36 years old. Within 2015, it is chief complaint is admitted to hospital because of right flank distending pain discomfort, abdominal distention, weak, body order yellowish urine, poor appetite. Be admitted to hospital symptom: body icteric sclera dye, yellowish urine, right flank distending pain are uncomfortable, height abdominal distention speech weak, lazy is hypologia, poor appetite, big loose stool, 3-4 times/day, pale tongue is fat, deep-thready pulse. Color ultrasound is shown: liver cirrhosis, has hepatitis B medical history. Biochemical analysis: albumin 20g/L. Tcm diagnosis is the liver rump, and pattern of syndrome is liver-depression and spleen-insufficiency type, and Western medicine diagnose is: (1) hbv-liver cirrhosis Decompensated stage (chronic active increases the weight of the phase); (2) hypoproteinemia (20g/L). Giving the liver protecting and ALT lowering of routine, nutritional support treatment after being admitted to hospital, give medicated diet snack at night at random three weeks, patient's body order yellowish urine substantially alleviates, and albumin raises (30g/L), and above-mentioned symptom is clearly better, and patient takes a turn for the better and leaves hospital.
2. Mrs Wang, female, peasant, 62 years old. Within 2015, it is admitted to hospital because of height abdominal distention, weak, poor appetite, extremity not warm being chief complaint. Be admitted to hospital symptom: darkish complexion, dyspnea, after abdominal distention poor appetite, food swollen very, fatigue and weakness, fear of cold, defecate rare, pale tongue is fat, stringy and thready pulse is unable. Color ultrasound is shown: liver cirrhosis, has hepatitis B medical history. Biochemical analysis: albumin 26g/L. Tcm diagnosis is the liver rump, and pattern of syndrome is stagnation of liver-QI with deficiency of the spleen, and Western medicine diagnose is: (1) hbv-liver cirrhosis Decompensated stage; (2) chronic hepatitis B Acute Exacerbation Period. Giving the liver protecting and ALT lowering of routine, nutritional support after being admitted to hospital, give medicated diet snack at night at random two weeks, urine volume increases, and albumin raises 32g/L. Above-mentioned symptom is clearly better, patient discharge.
3. Zhao so-and-so, man, peasant, 42 years old. In November, 2014 is chief complaint is admitted to hospital because of height abdominal distention, height jaundice, nausea and vomiting, deficiency of QI with disinclination to talk, loss of appetite. It is admitted to hospital symptom: yellow skin and eye, fatigue and weakness, repose lazy speech, abdominal distention. Pale tongue tongue is greasy, stringy and rolling pulse in vain. Color ultrasound is shown: liver cirrhosis, has hepatitis B medical history. Biochemical analysis: bilirubin: 625mol/L, albumin 23g/L. Tcm diagnosis is the liver rump, and pattern of syndrome is stagnation of liver-QI with deficiency of the spleen, and Western medicine diagnose is: (1) hbv-liver cirrhosis Decompensated stage; (2) chronic hepatitis B Acute Exacerbation Period. Giving infection, artificial liver in treatment and the liver protecting and ALT lowering, nutritional support after being admitted to hospital, namely give medicated diet snack at night surrounding, albumin raises 34g/L. Above-mentioned symptom is clearly better, and is in hospital 28 days, patient discharge. Following up a case by regular visits to over 1 year, patient's biochemical analysis is normal.
4. Lee so-and-so, female, cadre, 62 years old. Poor appetite was chief complaint and was admitted to hospital because of abdominal distention, weak activity postemphasis in June, 2014. It is admitted to hospital symptom: dim complexion, abdominal distention, weak, oliguria. Pale tongue tongue is white, stringy and rolling pulse. Color ultrasound is shown: liver cirrhosis, moderate ascites. Biochemical analysis: albumin 27g/L. Tcm diagnosis is the liver rump (tympanites), and pattern of syndrome is stagnation of liver-QI with deficiency of the spleen, and Western medicine diagnose is: (1) hbv-liver cirrhosis Decompensated stage; (2) ascites. Giving the liver protecting and ALT lowering, nutritional support after being admitted to hospital, coordinate and give medicated diet snack at night two weeks, albumin raises 30g/L.Above-mentioned symptom is clearly better, patient discharge.
Claims (5)
1. the medicated diet being used for improving liver cirrhosis nutritional status, it is characterised in that be that Fructus Jujubae 3-7, Semen oryzae sativae 2-8 part is made by Poria 5-15 part by weight, Rhizoma Dioscoreae 5-15 part, Semen Coicis 5-15 part, Fructus Citri Sarcodactylis 5-15 part, Endothelium Corneum Gigeriae Galli 1-6 part; The processing method of described medicated diet comprises the following steps:
1) raw material Poria is chosen by formula, Rhizoma Dioscoreae, Semen Coicis, Fructus Citri Sarcodactylis, Endothelium Corneum Gigeriae Galli, Fructus Jujubae, Semen oryzae sativae, through drying after Removing Kernel for Date, standby;
2) the raw material pulverizer of step 1) is processed into powder;
3) before sleeping half an hour or evening 9-10 point, by step 2) the powder boiled water furnishing 150-200ml rice processed sticks with paste and drinks;
4) snack at night should continue 3 months.
2. a kind of medicated diet for improving liver cirrhosis nutritional status according to claim 1, it is characterised in that be by Poria 7-10 part by weight, Rhizoma Dioscoreae 7-10 part, Semen Coicis 7-10 part, Fructus Citri Sarcodactylis 7-10 part, Endothelium Corneum Gigeriae Galli 3-5 part, Fructus Jujubae 4-5, Semen oryzae sativae 3-5 part is made; The processing method of described medicated diet comprises the following steps:
1) raw material Poria is chosen by formula, Rhizoma Dioscoreae, Semen Coicis, Fructus Citri Sarcodactylis, Endothelium Corneum Gigeriae Galli, Fructus Jujubae, Semen oryzae sativae, through drying after Removing Kernel for Date, standby;
2) the raw material pulverizer of step 1) is processed into powder;
3) before sleeping half an hour or evening 9-10 point, by step 2) the powder boiled water furnishing 150-200ml rice processed sticks with paste and drinks;
4) snack at night should continue 3 months.
3. a kind of medicated diet for improving liver cirrhosis nutritional status according to claim 1, it is characterised in that be by Poria 12-13 part by weight, Rhizoma Dioscoreae 12-13 part, Semen Coicis 12-13 part, Fructus Citri Sarcodactylis 12-13 part, Endothelium Corneum Gigeriae Galli 2-4 part, Fructus Jujubae 4-5, Semen oryzae sativae 4-6 part is made; The processing method of described medicated diet comprises the following steps:
1) raw material Poria is chosen by formula, Rhizoma Dioscoreae, Semen Coicis, Fructus Citri Sarcodactylis, Endothelium Corneum Gigeriae Galli, Fructus Jujubae, Semen oryzae sativae, through drying after Removing Kernel for Date, standby;
2) the raw material pulverizer of step 1) is processed into powder;
3) before sleeping half an hour or evening 9-10 point, by step 2) the powder boiled water furnishing 150-200ml rice processed sticks with paste and drinks;
4) snack at night should continue 3 months.
4. a kind of medicated diet for improving liver cirrhosis nutritional status according to claim 1, it is characterised in that be that Semen oryzae sativae 7 parts is made by 8 parts of Poria by weight, Rhizoma Dioscoreae 8 parts, Semen Coicis 8 parts, Fructus Citri Sarcodactylis 8 parts, Endothelium Corneum Gigeriae Galli 4 parts, 6, Fructus Jujubae; The processing method of described medicated diet comprises the following steps:
1) raw material Poria is chosen by formula, Rhizoma Dioscoreae, Semen Coicis, Fructus Citri Sarcodactylis, Endothelium Corneum Gigeriae Galli, Fructus Jujubae, Semen oryzae sativae, through drying after Removing Kernel for Date, standby;
2) the raw material pulverizer of step 1) is processed into powder;
3) before sleeping half an hour or evening 9-10 point, by step 2) the powder boiled water furnishing 150-200ml rice processed sticks with paste and drinks;
4) snack at night should continue 3 months.
5. a kind of medicated diet for improving liver cirrhosis nutritional status according to claim 1, it is characterised in that be that Semen oryzae sativae 4 parts is made by 14 parts of Poria by weight, Rhizoma Dioscoreae 14 parts, Semen Coicis 14 parts, Fructus Citri Sarcodactylis 14 parts, Endothelium Corneum Gigeriae Galli 3 parts, 4, Fructus Jujubae; The processing method of described medicated diet comprises the following steps:
1) raw material Poria is chosen by formula, Rhizoma Dioscoreae, Semen Coicis, Fructus Citri Sarcodactylis, Endothelium Corneum Gigeriae Galli, Fructus Jujubae, Semen oryzae sativae, through drying after Removing Kernel for Date, standby;
2) the raw material pulverizer of step 1) is processed into powder;
3) before sleeping half an hour or evening 9-10 point, by step 2) the powder boiled water furnishing 150-200ml rice processed sticks with paste and drinks;
4) snack at night should continue 3 months.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109999169A (en) * | 2019-04-19 | 2019-07-12 | 洪宜超 | It is a kind of for treating the Chinese medicine composition of cirrhosis |
| CN115088822A (en) * | 2022-06-02 | 2022-09-23 | 合肥师范学院 | Vegetable and fruit shake for adjuvant treatment of post-hepatitis B cirrhosis in compensatory stage and preparation method |
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| CN104351768A (en) * | 2014-10-22 | 2015-02-18 | 重庆市大足区季家镇卫生院 | Medicated diet for invigorating stomach and promoting digestion |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109999169A (en) * | 2019-04-19 | 2019-07-12 | 洪宜超 | It is a kind of for treating the Chinese medicine composition of cirrhosis |
| CN115088822A (en) * | 2022-06-02 | 2022-09-23 | 合肥师范学院 | Vegetable and fruit shake for adjuvant treatment of post-hepatitis B cirrhosis in compensatory stage and preparation method |
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| CN105663900B (en) | 2019-12-20 |
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