CN105663830A - Preparation taken during gallbladder-carcinoma-patient radiotherapy and chemotherapy - Google Patents
Preparation taken during gallbladder-carcinoma-patient radiotherapy and chemotherapy Download PDFInfo
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- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention discloses a preparation taken during gallbladder-carcinoma-patient radiotherapy and chemotherapy. The preparation is prepared from, by weight, 8-15 parts of corn flowers, 5-8 parts of Chinese pear-leaved crabapples, 4-9 parts of epimedium herbs, 0.5-1.8 parts of rhizomes of watt tupistra, 3-7 parts of thorny elaeagnus fruits, 8-11 parts of hens on bamboo rhizomes, 1-2 parts of ruddle, 0.8-1.8 parts of zebrina pendula, 3-5 parts of brassica oleracea, 10-16 parts of fruits of yellowfruit nightshade, 6-9 parts of roots of bilobed grewia, 7-12 parts of seeds of longleaf xylosma, 5-11 parts of roots of common bombax, 6-10 parts of arenaria brevipetala and 4-7 parts of pternopetalum vulgare. The preparation has the advantages that the preparation has the effects of dispelling wind, eliminating dampness, clearing heat, removing toxicity, removing stasis and relieving pain, the toxic and side effects of radiotherapy and chemotherapy can be effectively relieved, and the effects that effect increasing and toxicity decreasing are achieved, the life quality is improved, and the life is prolonged are achieved.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to preparation and the method for making taken during a kind of Gallbladder Carcinoma Patients chemicotherapy.
Background technology
Carcinoma of gallbladder is the malignant tumor that biliary system is common, and sickness rate is on the rise in recent years, women be higher than male, wherein in the majority with gerontal patient, early stage without specific clinical performance, it has been found that time mostly be middle and advanced stage. Due to B ultrasonic, extensively carrying out of the imaging examination such as CT, carcinoma of gallbladder is realized gradually, it has been found that rate increases. The happening part of carcinoma of gallbladder is common with neck of gallbladder and gallbladder body. Carcinoma of gallbladder early stage, gallbladder outward appearance is how normal, can enlargement or reduce, gallbladder wall can substantially thicken or became uneven, is uneven. The middle and advanced stage of carcinoma of gallbladder, in isolating hard lump or volume calculus very big, full or infecting the lump of bile. Due to oncothlipsis causes bile can not normal excretion, can not normally input gastrointestinal tract, thus causing digestive function abnormal, digest bad, bile can not normal excretion and be forced into blood, and cause skin Huang, yellow urine, yellow sclera (white of the eye jaundice), is called jaundice, and liver function test can find that icteric index is apparently higher than normally, what be in a bad way there is also skin pruritus, even generates heat and does not move back.
Carcinoma of gallbladder chemicotherapy can pass through the content directly killing cancerous cell and irritability raising blood middle leukocytes to reach to control the breeding of cancerous cell. After what carcinoma of gallbladder chemicotherapy was relatively many apply to radical surgery, it is therefore intended that prevention cancer recurrence. Or conditions of patients sharply worsens the also feasible carcinoma of gallbladder chemicotherapy needing emergency flight control. Although chemotherapy is the important means for the treatment of carcinoma of gallbladder, so that some patient produces chemicotherapy and relies on. Main reason is that a part of normal function of human body also can be caused damage by chemicotherapy while bringing therapeutic effect, the especially inhibitory action of myeloplast hemopoietic, so can often occur once doing chemicotherapy improvement. But it has bigger side effect in the treatment. Therefore, by Chinese medicine auxiliary treatment during row carcinoma of gallbladder chemicotherapy, to play the effect of efficacy enhancing and toxicity reducing.
The traditional Chinese medical science is thought, primary disease belongs to the sick category such as Chinese medicine " hypochondriac pain ", " jaundice ", " amassing ". Gallbladder and liver the exterior and the interior each other, hold digestion communications centre, and Primary Carcinoma of The Gallbladder is many because of Yu Huahuo, and bright Tianjin is expectorant, and knot forms disease; Or internal injury caused by excess of seven emotions is with the passing of time, depression of liver-QI is not understood, eating and drinking without temperance etc. Chinese traditional treatment disease acts on the principle of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, and carcinoma of gallbladder is according to clinical manifestation, and its pattern of syndrome can be divided into irritability stasis, ecchymosis to pent up, damp-heat blocking in the body etc., and controlling should depressed liver-energy dispersing and QI regulating, blood stasis dispelling removing toxic substances, clearing away heat-damp and promoting diuresis.The Chinese medicine treatment to carcinoma of gallbladder, it is possible to play stable tumor, relief of symptoms, alleviates chemicotherapy toxicity, improves life quality, the effect of extending life.
Application publication number CN105012760A(application number 201510507121.X) Chinese invention patent document disclose a kind of Chinese medicine alleviating and treat carcinoma of gallbladder, it is made up of the raw material of Chinese medicine of following weight proportioning: Radix Aristolochiae 5-8 part, Semen Aesculi 3-5 part, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 5-15 part, Flos jasmini 5-8 part, Radix Polygalae 10-20 part, Radix Serissae 3-7 part, Folium Callicarpae Formosanae 3-5 part, Radix Malloti Apelitae 3-8 part, Stigma Croci 2-9 part, Herba sporoboli purpureasuffusi 2-5 part, Radix Sophorae Viciifoliae 2-4 part, Radix Pteroxygoni Giraldii 3-5 part, Pseudobulbus Cremastrae Seu Pleiones 5-8 part, Resina Liquidambaris 3-9 part, Semen Caesalpiniae Minacis 2-5 part, ten liang of leaf 1-3 parts. Application publication number CN104189675A(application number 201410431240.7) Chinese invention patent document disclose a kind of Chinese medicine preparation treating carcinoma of gallbladder postoperative recurrence, be made up of the crude drug of following proportioning: Radix Gentianae 9-12g, Rhizoma Sparganii 4-6g, Radix Inulae 6-9g, Coriolous Dersicolor (Fr.) Quel 9-12g, Cortex Acanthopancis 6-9g, Radix Semiaquilegiae 8-12g, Herba Silybi mariani 6-9g, Fructus Polygoni Orientalis 8-12g, Resina Liquidambaris 6-9g, purslane speedwell Herba 6-8g, Radix Glycyrrhizae 4-6g.
Up to now, operation and Radiotherapy chemotherapy treatment remain the most basic treatment means of cancer of pancreas, are also the important means being hopeful to obtain curative therapy. Owing in chemicotherapy process, immunity degradation occurs in patient, anti-infection ability, body compensation reduce, poor resistance, and serious complication easily occurs. Therefore, Chinese medicine auxiliary treatment is particularly important.
Summary of the invention
For the deficiencies in the prior art, it is an object of the invention to provide the preparation a kind of prepared simply, conveniently take, safely and effectively take during Gallbladder Carcinoma Patients chemicotherapy. Said preparation can effectively alleviate the toxic and side effects of chemicotherapy, strengthens therapeutic effect.
The technical scheme is that
The preparation taken during Gallbladder Carcinoma Patients chemicotherapy, is prepared from by following bulk drugs, is weight portion: popcorn 8-15; Fructus Mali Asiaticae 5-8; Herba Epimedii 4-9; Rhizoma Tupistrae Wattii 0.5-1.8; Fructus Elaeagni 3-7; Rhizoma Phyllostachydis henonis 8-11; Haematitum 1-2; Herba Zebrinae Pendulae 0.8-1.8; Caulis et Folium Brassicae capitatae 3-5; Fructus solani xanthocarpi 10-16; Radix grewiae bilobae 6-9; Break 7-12 by a fall; Radix Gossampini 5-11; Herba arenariae kansuensis 6-10; Zijin sand 4-7.
In preferred scheme, popcorn 10-13; Fructus Mali Asiaticae 6-7; Herba Epimedii 5-8; Rhizoma Tupistrae Wattii 0.9-1.4; Fructus Elaeagni 4-6; Rhizoma Phyllostachydis henonis 9-10; Haematitum 1.3-1.7; Herba Zebrinae Pendulae 1.1-1.5; Caulis et Folium Brassicae capitatae 3.5-4.5; Fructus solani xanthocarpi 12-14; Radix grewiae bilobae 7-8; Break 9-10 by a fall; Radix Gossampini 7-9; Herba arenariae kansuensis 7-9; Zijin sand 5-6.
More preferably, popcorn 11.5; Fructus Mali Asiaticae 6.5; Herba Epimedii 6.5; Rhizoma Tupistrae Wattii 1.2; Fructus Elaeagni 5; Rhizoma Phyllostachydis henonis 9.5; Haematitum 1.5; Herba Zebrinae Pendulae 1.3; Caulis et Folium Brassicae capitatae 4; Fructus solani xanthocarpi 13; Radix grewiae bilobae 7.5; Break 9.5 by a fall; Radix Gossampini 8; Herba arenariae kansuensis 8; Zijin sand 5.5.
The preparation method of the preparation pill taken during Gallbladder Carcinoma Patients chemicotherapy, step is as follows:
(1) Fructus solani xanthocarpi and Fructus Mali Asiaticae mixing, mix thoroughly with rice wine, vexed 15-25 minute (preferably vexed 20 minutes), and being subsequently placed on tile intense fire dries, and smashs into fine powder to pieces, standby; Replacing Haematitum and smash into coarse grain to pieces, intense fire is calcined to and is popular in, and puts into and quenches once in white vinegar, takes out, is ground into fine powder, standby;
(2) popcorn, Herba Epimedii, Caulis et Folium Brassicae capitatae, Radix Gossampini and the mixing of Zijin sand, fully dry, pulverize into fine powder, standby;
(3) Herba Zebrinae Pendulae is placed in medicine pot, spray Sucus Zingberis, slow fire stir-fries 3-7 minute (preferred slow fire stir-fries 5 minutes), take out, with Fructus Elaeagni, Rhizoma Tupistrae Wattii, Rhizoma Phyllostachydis henonis, Radix grewiae bilobae, break by a fall and Herba arenariae kansuensis is together placed in frying pan, add the clear water (preferably adding the clear water of 7.5 times amount) of 6-9 times amount, slow fire boiling 30-60 minute (preferred slow fire boiling 45 minutes), filtering, filtrate reduced in volume becomes thick paste, standby;
(4) step (1) and (2) gained fine powder are joined in step (3) gained thick paste, mixing, make the pill of Semen Firmianae size, to obtain final product.
The preparation method of the preparation pill taken during above-mentioned Gallbladder Carcinoma Patients chemicotherapy, preferred scheme is, in step (1), the amount of rice wine is described raw material dose 0.28-0.46 times (amount of preferred rice wine is 0.34-0.4 times of described raw material dose, it is more preferable to measuring of rice wine be 0.37 times of described raw material dose).
The preparation method of described tablet is:
(1) replacing Haematitum and smash into coarse grain to pieces, intense fire is calcined to and is popular in, and puts into and quenches once in white vinegar, takes out, is ground into fine powder, standby;
(2) Herba Zebrinae Pendulae and Rhizoma Tupistrae Wattii mixing, add the Chinese liquor (being preferably added to the Chinese liquor of 4 times amount) of 3-5 times amount, and room temperature lower seal soaks 12-20 hour (preferred room temperature lower seal soaks 16 hours), take out, be placed in medicine pot, slow fire fried dry, take out, be ground into fine powder, standby;
(3) surplus stock medicine is together ground to form coarse powder, add the ethanol that concentration is 65%, reflux, extract, twice, respectively extract 18-36 minute (preferably each each extraction 27 minutes) every time, merge twice extracting solution, filter, filtrate recycling ethanol, concentrating under reduced pressure becomes thick paste, spray drying to get dry extract powder, standby;
(4) step (1) and step (2) gained fine powder are mixed with step (3) gained dried cream powder, add the magnesium stearate that mass fraction is 2.1% and the dextrin fine powder that mass fraction is 4.5%, mixing, sieve, be pressed into tablet, to obtain final product.
The preparation method of the formulation tablet taken during above-mentioned Gallbladder Carcinoma Patients chemicotherapy, preferred scheme is, in step (3), the amount of ethanol is coarse powder amount 7.5-10.5 times (amount of preferred ethanol is 8.5-9.5 times of coarse powder amount, it is more preferable to measuring of ethanol be 9 times of coarse powder amount).
The preparation method of the formulation tablet taken during above-mentioned Gallbladder Carcinoma Patients chemicotherapy, it is preferred that scheme is, step (4) is crossed 120-160 mesh sieve (preferred cross 130-150 mesh sieve, it is more preferable to mistake 140 mesh sieve).
The preparation method of described water preparation is:
(1) replacing Haematitum and smash into coarse grain to pieces, intense fire is calcined to and is popular in, and puts into and quenches once in white vinegar, takes out, and is ground into fine powder, crosses 40-80 mesh sieve (preferred mistake 60 mesh sieve), standby;
(2) Herba Zebrinae Pendulae and Rhizoma Tupistrae Wattii mixing, add the Chinese liquor (being preferably added to the Chinese liquor of 4 times amount) of 3-5 times amount, and room temperature lower seal soaks 12-20 hour (preferably seal and soak 16 hours), takes out, standby; Herba Epimedii being chopped up silk, pours in the Oleum Sesami made popular, slow fire is fried to slightly yellow, takes out, standby;
(3) crude drug and popcorn, Fructus Mali Asiaticae, Fructus Elaeagni, Rhizoma Phyllostachydis henonis, Caulis et Folium Brassicae capitatae, Fructus solani xanthocarpi, Radix grewiae bilobae after step (2) being processed, break by a fall, Radix Gossampini, Herba arenariae kansuensis and Zijin sand are together placed in frying pan, add clear water and do not have powder 3-5cm, first intense fire heated and boiled 2-6 minute (preferred intense fire heated and boiled 4 minutes), it is subsequently adding the Haematitum after step (1) processes, turn slow fire boiling 40-70 minute (preferably turning slow fire boiling 60 minutes), filtering, filtrate is standby;
(4) by step (3) gained filtrate reduced in volume to the 1/2 of original volume, filtering through double-deck cotton cloth, sterilizing encapsulates, and to obtain final product.
The preparation method of described granule is:
(1) replacing Haematitum and smash into coarse grain to pieces, intense fire is calcined to and is popular in, and puts into and quenches once in white vinegar, takes out, is ground into fine powder, standby;
(2) popcorn, Radix Gossampini and Herba Epimedii being mixed, add the Mel (being preferably added to the Mel of 0.65 times amount) of 0.5-0.8 times amount, mix thoroughly, slow fire stir-fries to tack-free and takes out for spending, and dries, smashs into fine powder to pieces, standby;
(3) Fructus Elaeagni, Fructus Mali Asiaticae and Fructus solani xanthocarpi mixing, be placed in medicine cookeding pot, and mild and heavy respiration alternately stir-fries to medical material cracker, then sprays yellow wine, continues slow fire and stir-fries 6-10 minute (preferably continuing to slow fire stir-fry 8 minutes), and taking-up cools, and smashs into fine powder to pieces, standby;
(4) surplus stock medicine is placed in baker fully dry, it is ground into fine powder, mix with step (1)-(3) gained fine powder, add mass fraction be 1.9% hydroxypropyl cellulose and mass fraction be 3% sucrose fine, mixing, cross 90-130 mesh sieve (preferred mistake 110 mesh sieve), make bead dosage form according to the processing mode of granule, to obtain final product.
The preparation recipe science taken during Gallbladder Carcinoma Patients chemicotherapy of the present invention, preparation method is simple, and taking convenience, effect are notable. In addition, the excellent results of the present invention is also manifested by:
1, the tradition property of medicine is organically combined by the present invention with Chinese medicine modern pharmacology, using drugs to form a prescription, promotes curative effect; Taking convenience, safely, has no side effect;
2, the present invention has expelling wind and removing dampness, heat-clearing and toxic substances removing, effect of removing obstruction for relieving pain, can effectively alleviate chemicotherapy toxicity, plays efficacy enhancing and toxicity reducing, improves life quality, the effect of extending life;
3, medicine source of the present invention is easy to get, and medical material is with low cost, determined curative effect, has higher promotional value.
Detailed description of the invention
Describe technical scheme in detail below in conjunction with embodiment and experimental example, but protection domain is not limited to this.
The preparation taken during embodiment 1 Gallbladder Carcinoma Patients chemicotherapy, is prepared from by following bulk drugs, is weight portion (80g/ part): popcorn 8 parts; Fructus Mali Asiaticae 5 parts; Herba Epimedii 4 parts; Rhizoma Tupistrae Wattii 0.5 part; Fructus Elaeagni 3 parts; Rhizoma Phyllostachydis henonis 8 parts; Haematitum 1 part; Herba Zebrinae Pendulae 0.8 part; Caulis et Folium Brassicae capitatae 3 parts; Fructus solani xanthocarpi 10 parts; Radix grewiae bilobae 6 parts; Break 7 parts by a fall; Radix Gossampini 5 parts; Herba arenariae kansuensis 6 parts; Husky 4 parts of Zijin.
The preparation method of the preparation pill taken during Gallbladder Carcinoma Patients chemicotherapy is:
(1) Fructus solani xanthocarpi and Fructus Mali Asiaticae mixing, the rice wine adding 0.28 times of described raw material dose is mixed thoroughly, vexed 15 minutes, is subsequently placed on tile intense fire and dries, smashs into fine powder to pieces, standby; Replacing Haematitum and smash into coarse grain to pieces, intense fire is calcined to and is popular in, and puts into and quenches once in white vinegar, takes out, is ground into fine powder, standby;
(2) popcorn, Herba Epimedii, Caulis et Folium Brassicae capitatae, Radix Gossampini and the mixing of Zijin sand, fully dry, pulverize into fine powder, standby;
(3) Herba Zebrinae Pendulae is placed in medicine pot, sprays Sucus Zingberis, and slow fire stir-fries 3 minutes, takes out, with Fructus Elaeagni, Rhizoma Tupistrae Wattii, Rhizoma Phyllostachydis henonis, Radix grewiae bilobae, break by a fall and Herba arenariae kansuensis is together placed in frying pan, add the clear water of 6 times amount, slow fire boiling 30 minutes, filtering, filtrate reduced in volume becomes thick paste, standby;
(4) step (1) and (2) gained fine powder are joined in step (3) gained thick paste, mixing, make the pill of Semen Firmianae size, to obtain final product.
The instructions of taking of gained pill of the present invention is: every day three times, each 6-8 ball, and warm water takes, 20 days courses for the treatment of.
The preparation taken during embodiment 2 Gallbladder Carcinoma Patients chemicotherapy, is prepared from by following bulk drugs, is weight portion (40g/ part): popcorn 15 parts; Fructus Mali Asiaticae 8 parts; Herba Epimedii 9 parts; Rhizoma Tupistrae Wattii 1.8 parts; Fructus Elaeagni 7 parts; Rhizoma Phyllostachydis henonis 11 parts; Haematitum 2 parts; Herba Zebrinae Pendulae 1.8 parts; Caulis et Folium Brassicae capitatae 5 parts; Fructus solani xanthocarpi 16 parts; Radix grewiae bilobae 9 parts; Break 12 parts by a fall; Radix Gossampini 11 parts; Herba arenariae kansuensis 10 parts; Husky 7 parts of Zijin.
The preparation method of the formulation tablet taken during Gallbladder Carcinoma Patients chemicotherapy is:
(1) replacing Haematitum and smash into coarse grain to pieces, intense fire is calcined to and is popular in, and puts into and quenches once in white vinegar, takes out, is ground into fine powder, standby;
(2) Herba Zebrinae Pendulae and Rhizoma Tupistrae Wattii mixing, add the Chinese liquor of 4 times amount, and room temperature lower seal soaks 16 hours, takes out, is placed in medicine pot, and slow fire fried dry is taken out, is ground into fine powder, standby;
(3) surplus stock medicine is together ground to form coarse powder, add the ethanol that concentration is 65% of 9 times of coarse powder amounts, reflux, extract, twice, every time each extraction 27 minutes, merge twice extracting solution, filter, filtrate recycling ethanol, concentrating under reduced pressure becomes thick paste, spray drying to get dry extract powder, standby;
(4) step (1) and step (2) gained fine powder are mixed with step (3) gained dried cream powder, add the magnesium stearate that mass fraction is 2.1% and the dextrin fine powder that mass fraction is 4.5%, mixing, cross 140 mesh sieves, be pressed into tablet, to obtain final product.
The instructions of taking of gained tablet of the present invention is: every day three times, each 4-6 sheet, and warm water takes, 20 days courses for the treatment of.
Model case: old XX, man, 51 years old, people from Hebei. Patient is to our hospital on July 11st, 2011. Patient's readme: occur that right side abdomen pain is uncomfortable without obvious inducement before two weeks, from the beginning of slightly, in persistence, increase the weight of gradually, without Nausea and vomiting, without shoulder back radiating pain, without heating, shiver with cold, accompanies abdominal distention, occasionally has belch. Checking: patient's abdominal part is smooth, upper right abdomen is shown in and is dispersed in red macule, and without blister, without tenderness, right lumbar region show mottle rash, multiple blister is seen on surface, and tenderness is obvious. Through color ultrasound, CT examination prompting: carcinoma of gallbladder occupying lesion, gallbladder position lump is about 1cm. Row chemotherapeutic treatment, during treatment, there are the uncomfortable reactions such as retch in patient, agrees to through patient and family members thereof, take the formulation tablet taken during the present embodiment gained Gallbladder Carcinoma Patients chemicotherapy, instructions of taking: every day three times, each 4-6 sheet, warm water takes, 20 days courses for the treatment of. After taking two courses for the treatment of, patient is conscious, and uncomfortable symptom substantially alleviates, and CT examination gallbladder lump is obviously reduced; After taking four courses for the treatment of, patient's lump disappears, and health, without any discomfort, is paid a return visit after half a year, without recurrence.
The preparation taken during embodiment 3 Gallbladder Carcinoma Patients chemicotherapy, is prepared from by following bulk drugs, is weight portion (70g/ part): popcorn 10 parts; Fructus Mali Asiaticae 6 parts; Herba Epimedii 5 parts; Rhizoma Tupistrae Wattii 0.9 part; Fructus Elaeagni 4 parts; Rhizoma Phyllostachydis henonis 9 parts; Haematitum 1.3 parts; Herba Zebrinae Pendulae 1.1 parts; Caulis et Folium Brassicae capitatae 3.5 parts; Fructus solani xanthocarpi 12 parts; Radix grewiae bilobae 7 parts; Break 9 parts by a fall; Radix Gossampini 7 parts; Herba arenariae kansuensis 7 parts; Husky 5 parts of Zijin.
The preparation method of the preparation water preparation taken during Gallbladder Carcinoma Patients chemicotherapy is:
(1) replacing Haematitum and smash into coarse grain to pieces, intense fire is calcined to and is popular in, and puts into and quenches once in white vinegar, takes out, and is ground into fine powder, crosses 60 mesh sieves, standby;
(2) Herba Zebrinae Pendulae and Rhizoma Tupistrae Wattii mixing, add the Chinese liquor of 4 times amount, and room temperature lower seal soaks 16 hours, takes out, standby;Herba Epimedii being chopped up silk, pours in the Oleum Sesami made popular, slow fire is fried to slightly yellow, takes out, standby;
(3) crude drug and popcorn, Fructus Mali Asiaticae, Fructus Elaeagni, Rhizoma Phyllostachydis henonis, Caulis et Folium Brassicae capitatae, Fructus solani xanthocarpi, Radix grewiae bilobae after step (2) being processed, break by a fall, Radix Gossampini, Herba arenariae kansuensis and Zijin sand are together placed in frying pan, add clear water and do not have powder 3-5cm, first intense fire heated and boiled 4 minutes, it is subsequently adding the Haematitum after step (1) processes, turn slow fire boiling 60 minutes, filtering, filtrate is standby;
(4) by step (3) gained filtrate reduced in volume to the 1/2 of original volume, filtering through double-deck cotton cloth, sterilizing encapsulates, and to obtain final product.
The instructions of taking of gained water preparation of the present invention is: twice daily, each 120-150mL, and warm is taken, 20 days courses for the treatment of.
The preparation taken during embodiment 4 Gallbladder Carcinoma Patients chemicotherapy, is prepared from by following bulk drugs, is weight portion (50g/ part): popcorn 13 parts; Fructus Mali Asiaticae 7 parts; Herba Epimedii 8 parts; Rhizoma Tupistrae Wattii 1.4 parts; Fructus Elaeagni 6 parts; Rhizoma Phyllostachydis henonis 10 parts; Haematitum 1.7 parts; Herba Zebrinae Pendulae 1.5 parts; Caulis et Folium Brassicae capitatae 4.5 parts; Fructus solani xanthocarpi 14 parts; Radix grewiae bilobae 8 parts; Break 10 parts by a fall; Radix Gossampini 9 parts; Herba arenariae kansuensis 9 parts; Husky 6 parts of Zijin.
The preparation method of the preparation granules agent taken during Gallbladder Carcinoma Patients chemicotherapy is:
(1) replacing Haematitum and smash into coarse grain to pieces, intense fire is calcined to and is popular in, and puts into and quenches once in white vinegar, takes out, is ground into fine powder, standby;
(2) popcorn, Radix Gossampini and Herba Epimedii being mixed, add the Mel of 0.65 times amount, mix thoroughly, slow fire stir-fries to tack-free and takes out for spending, and dries, smashs into fine powder to pieces, standby;
(3) Fructus Elaeagni, Fructus Mali Asiaticae and Fructus solani xanthocarpi mixing, be placed in medicine cookeding pot, and mild and heavy respiration alternately stir-fries to medical material cracker, then sprays yellow wine, continues slow fire and stir-fries 8 minutes, and taking-up cools, and smashs into fine powder to pieces, standby;
(4) surplus stock medicine is placed in baker fully dry, it is ground into fine powder, mix with step (1)-(3) gained fine powder, add mass fraction be 1.9% hydroxypropyl cellulose and mass fraction be 3% sucrose fine, mixing, cross 110 mesh sieves, make bead dosage form according to the processing mode of granule, to obtain final product.
The instructions of taking of gained granule of the present invention is: every day three times, each 10-15g, and warm water is taken after mixing it with water, 20 days courses for the treatment of.
Model case: Lee XX, female, 60 years old, people from Shandong. Patient is to our hospital on October 22nd, 2013. Patient's readme: without obvious inducement, right flank distending pain occurred before half a year, after rest, pain can spontaneous remission, within nearly one month, pain substantially increases the weight of, pain emits to right shoulder back, often sense vexed swollen, the belch of right upper quadrant of the abdomen, pain time extends, skin, mucosa xanthochromia, through color ultrasound, CT examination prompting: carcinoma of gallbladder occupying lesion, the lump that gallbladder position is about 1.5 centimetres. Agree to through patient and family members, carry out chemicotherapy treatment. During treatment, there is the serious side reaction such as Nausea and vomiting and blood change in patient, agrees to through patient and family members thereof, takes the preparation granules agent taken during the present embodiment gained Gallbladder Carcinoma Patients chemicotherapy, instructions of taking: every day three times, each 10-15g, warm water is taken after mixing it with water, 20 days courses for the treatment of. After taking two courses for the treatment of, patient is conscious, and uncomfortable symptom substantially alleviates, and CT examination gallbladder lump is obviously reduced; After taking four courses for the treatment of, patient's lump disappears, and health, without any discomfort, is paid a return visit after half a year, without recurrence.
The preparation taken during embodiment 5 Gallbladder Carcinoma Patients chemicotherapy, is prepared from by following bulk drugs, is weight portion (60g/ part): popcorn 11.5 parts; Fructus Mali Asiaticae 6.5 parts; Herba Epimedii 6.5 parts; Rhizoma Tupistrae Wattii 1.2 parts; Fructus Elaeagni 5 parts; Rhizoma Phyllostachydis henonis 9.5 parts; Haematitum 1.5 parts; Herba Zebrinae Pendulae 1.3 parts; Caulis et Folium Brassicae capitatae 4 parts; Fructus solani xanthocarpi 13 parts; Radix grewiae bilobae 7.5 parts; Break 9.5 parts by a fall; Radix Gossampini 8 parts; Herba arenariae kansuensis 8 parts; Husky 5.5 parts of Zijin.
The preparation method of the preparation pill taken during Gallbladder Carcinoma Patients chemicotherapy is:
(1) Fructus solani xanthocarpi and Fructus Mali Asiaticae mixing, the rice wine adding 0.37 times of described raw material dose is mixed thoroughly, vexed 20 minutes, is subsequently placed on tile intense fire and dries, smashs into fine powder to pieces, standby; Replacing Haematitum and smash into coarse grain to pieces, intense fire is calcined to and is popular in, and puts into and quenches once in white vinegar, takes out, is ground into fine powder, standby;
(2) popcorn, Herba Epimedii, Caulis et Folium Brassicae capitatae, Radix Gossampini and the mixing of Zijin sand, fully dry, pulverize into fine powder, standby;
(3) Herba Zebrinae Pendulae is placed in medicine pot, sprays Sucus Zingberis, and slow fire stir-fries 5 minutes, takes out, with Fructus Elaeagni, Rhizoma Tupistrae Wattii, Rhizoma Phyllostachydis henonis, Radix grewiae bilobae, break by a fall and Herba arenariae kansuensis is together placed in frying pan, add the clear water of 7.5 times amount, slow fire boiling 45 minutes, filtering, filtrate reduced in volume becomes thick paste, standby;
(4) step (1) and (2) gained fine powder are joined in step (3) gained thick paste, mixing, make the pill of Semen Firmianae size, to obtain final product.
The instructions of taking of gained pill of the present invention is: every day three times, each 6-8 ball, and warm water takes, 20 days courses for the treatment of.
The pharmacology of the present invention main raw material of Chinese medicine used is as follows:
Popcorn: base: for the zeistic male flower fringe of grass. Nature and flavor: sweet in the mouth; Cool in nature. Pharmacological action: 1. on hyperlipidemia and atherosclerotic impact, 5g/kg gavage that Pollen Maydis (adds normal saline, homogenate is broken, centrifugal fears supernatant liquid filtering) can effectively suppress intravenous injection TirtonWR-1339 or feed the rising of mice serum T-CHOL that hypercholesterolemia causes, triacylglycerol. 2. resist myocardial ischemia, anoxia functions, Pollen Maydis supernatant 0.25g/kg lumbar injection, can the myocardial ischemia in rats that causes of significant antagonism pituitrin, make myocardial ischemia reacting positive rate substantially reduce; Extend the electrocardio extinction time after mouse breathing stops. 3. improving micro_circulation effect, Pollen Maydis supernatant 0.25g/kg lumbar injection can substantially alleviate the cloudy stagnant formation with microthrombus of suslik blood flow that high molecular dextran causes, improve erythrocyte aggregation, alleviate high molecular dextran and raise the effect of rat whole blood specific viscosity. 4. antifatigue effect. Function cures mainly: depressed liver-energy dispersing and function of gallbladder promoting. Main hepatitis; Cholecystitis.
Fructus Mali Asiaticae: base: for the fruit of rosaceous plant premium. Chemical analysis: fruit is containing folic acid. Nature and flavor: sour, sweet; Temperature; Nontoxic. Gui Jing: the heart; Liver; Lung meridian. Function cures mainly: therapeutic method to keep the adverse QI flowing downwards the chest stuffiness relieving, promoting the production of body fluid to quench thirst, relieving pain by regulating middle-JIAO. Main phlegm retention food stagnation, chest and diaphragm painful abdominal mass plug, quench one's thirst, cholera, stomachache of vomiting and diarrhoea, dysentery.
Herba Epimedii: base: for the stem and leaf of Berberidaceae plant Herba Epimedii, Epimedium brevicornum or Epimedium sagittatum. Chemical analysis: Herba Epimedii stem, leaf are containing icariine, and leaf is still containing volatile oil, ceryl alcohol, 1 alkane, plant sterol, tannin, oils and fats. Fatty acid in fatty oil has Palmic acid, stearic acid, oleic acid, linoleic acid. Pharmacological action: 1. affect sexual function; 2. microorganism there is inhibitory action;3. antitussive, eliminate the phlegm and antiasthmatic effect; 4. other effects: rabbit is had a hypotensive effect by extraction ofHerba Epimedii, makes the secretion of urine increase in a small amount, then suppresses it in a large number on the contrary, isolated rabbit intestinal is had inhibitory action, suppression after isolated uterine then first excitement, oral hyperglycemic rat blood glucose can be made to decline. Nature and flavor: Xin Gan, temperature. Gui Jing: enter liver, kidney channel. Function cures mainly: kidney invigorating and YANG supporting, expelling wind and removing dampness. Controlling sexual impotence not lift, dribbling urination, muscles and bones contraction is anxious, and hemiplegia, weakness of the waist and knees, rheumatic arthralgia, extremity are meciless.
Rhizoma Tupistrae Wattii: base: for the rhizome of liliaceous plant handle leaf Tupistra chinensis Bak.. Nature and flavor: arduous, cold, mild toxicity. Function cures mainly: heat-clearing and toxic substances removing; Dissipating blood stasis stops blooding; Reducing swelling and alleviating pain. Main cold anemopyretic; Cough pharyngalgia; Tonsillitis; Lymphadenitis; Injury and bone fracture; Stomachache is spitted blood; Traumatic hemorrhage.
Fructus Elaeagni: base: for the fruit of Elaeangnaceae plant Fructus Elaeagni. Chemical analysis: flower is containing volatile oil. Nature and flavor: acid; Puckery; Flat. Gui Jing: lung; Stomach; Large intestine channel. Function cures mainly: astringing to arrest diarrhea; Strengthening the spleen to promote digestion; Relieving cough and asthma; Hemostasis. Master has loose bowels; Dysentery; Inappetence; Dyspepsia; Cough and asthma; Metrorrhagia; Hemorrhoid hematochezia.
Rhizoma Phyllostachydis henonis: base: for the rhizome of Gramineae plant phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle. Nature and flavor: sweet; Light; Cold. Function cures mainly: clearing heat and relieving fidgetness; Clearing away phlegm is calmed the frightened. Main heating is vexed; Palpitation with fear; Pediatric epilepsy scared.
Haematitum: base: for the Ore of oxide-based mineral bloodstone. Chemical analysis: main containing iron sesquioxide, wherein ferrum 70%, oxygen 30%, sometimes impure titanium, magnesium, aluminum, silicon and moisture. Nature and flavor: bitter, sweet, flat. Gui Jing: return liver, stomach, heart born of the same parents' warp. Function cures mainly: suppressing the hyperactive liver town is inverse, cooling blood for hemostasis. Control eructation vomiting, dysphagia and regurgitation, asthma, infantile convulsion, spit blood, epistaxis, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, bleeding not during menses.
Herba Zebrinae Pendulae: base: for the herb of Commelianaceae plant Herba Zebrinae Pendulae. Chemical analysis: stem and leaf are containing calcium oxalate and natural gum. Pharmacological action: isolated guinea pig ileum is had excitation by the decoct of leaf and stem and water extract (add ethanol and remove precipitation person), to isolated rat uterus, extrasomatic rabbit heart and duodenum all without obvious effect, water extract has vasodilator effect in rat hindlimb perfusion experiment. Nature and flavor: " Fujian traditional herbal medicine ": " sweet, cold, poisonous. " function cures mainly: controlling cough and spitting blood, gonorrhea, leucorrhea, dysentery, carbuncle poison.
Caulis et Folium Brassicae capitatae: base: for the leaf of crucifer Caulis et Folium Brassicae capitatae. Pharmacological action: seed extract has some bacteriostasis. Its leaf (heat treated) is applied to local stimulation, can alleviate gallbladder disease. Nature and flavor: sweet; Flat. Gui Jing: stomach; Kidney channel. Function cures mainly: eliminating damp-heat; Removing obstruction for relieving pain; Kidney tonifying qi-restoratives. Main jaundice due to damp-heat; Digestive tract ulcer pain; Articular instability; Deficient.
Fructus solani xanthocarpi: base: for the root of plant of Solanaceae Fructus solani xanthocarpi, fruit and seed. Chemical analysis: fruit is containing solanine, solasonine, and they are all sugary alkaloids, hydrolysis then generates Solanidine or solasodine and glucose, rhamnose, galactose respectively. Fatty oil and sterols again; Fatty oil is semi-drying, and its fatty acid is oleic acid 42.93, linoleic acid 36.18, palmitic acid 5.37, stearic acid 9.77% etc., and one of sterol is carpesterol. Also containing diosgenin; Ash is 5.9%, wherein contains Fe, Cl etc. of K, Na, Mg and vestige. Nature and flavor: toil, temperature. Function cures mainly: clearing away heat-damp and promoting diuresis, repercussive pain relieving.
Radix grewiae bilobae: base: for the Herb of Tiliaceae plant bilobed grewia.Nature and flavor: sweet; Bitter; Temperature. Gui Jing: liver; Spleen; Stomach warp. Function cures mainly: invigorating the spleen and benefiting QI; Expelling wind and removing dampness; Treating spontaneous emission and leukorrhagia. Main insufficiency of the spleen lack of appetite; Proctoptosis of a specified duration; Infantile malnutrition; Ascariasis; Rheumatic arthralgia; Seminal emission; Metrorrhagia; Leukorrhagia; Uterine prolapse.
Break by a fall: base: for the leaf of Flacourtiaceae plant longleaf xylosma, thorn and seed. Nature and flavor: Guangzhou air force " conventional Chinese herbal medicine handbook ": " bitter in the mouth, cold in nature. " function cures mainly: 1. " register planted by Guangxi medicine ": " seed: control amenorrhea, skin ulcer tinea, scrofula; Thorn: lactogenic. " 2. Guangzhou air force " conventional Chinese herbal medicine handbook ": " cool the blood dissipate blood stasis, reducing swelling and alleviating pain. Control bruise or fracture, dislocation. "
Radix Gossampini: base: for root or the root bark of Bombacaceae plant kapok. Chemical analysis: root is containing tannin and kapok glue. Root bark is containing lupeol. Nature and flavor: mildly bitter flavor; Cool in nature. Gui Jing: spleen; Stomach warp. Function cures mainly: expelling wind and removing dampness; Heat-clearing and toxic substances removing; Removing obstruction for relieving pain. Main air pain of dampness syndrome; Stomachache; Bloody dysentery; Puerperal edema; Scrofula; Osteopatia sprain.
Herba arenariae kansuensis: base: for the herb of pinkwort Gansu sandwort. Nature and flavor: sweet; Bitter; Cold in nature. Gui Jing: liver; Gallbladder; Kidney channel. Function cures mainly: clearing and antitussive; Dampness removing jaundice eliminating; Exempt from numbness pain relieving. Main fever caused by exogenous pathogens; Cough due to lung-heat; Jaundice; Stranguria with turbid discharge; Rheumatic arthralgia; Hypertension.
Zijin is husky: base: Umbelliferae Pternopetalum plant capsule lobe celery, is used as medicine with root. Nature and flavor: pungent, temperature. Function cures mainly: cold expelling, regulates the flow of vital energy, pain relieving. For having a stomachache, stomachache, chest and hypochondrium.
The clinical practice of the preparation (embodiment 5) taken during test example gained Gallbladder Carcinoma Patients chemicotherapy of the present invention:
1 data and method
1.1 physical data
Choosing Gallbladder Carcinoma Patients totally 376 example that in October ,-2014 in April, 2012, my institute accepted for medical treatment, wherein male patient's totally 180 example, female patient is totally 196 example, and the age is in 46-70 year, 55 years old mean age. All patients are all diagnosed as carcinoma of gallbladder through pathological examination.
1.2 Therapeutic Method
All patients are randomly divided into experimental group and matched group, and two groups of patients, in sex, age, the state of an illness etc., through statistical procedures no significant difference (P > 0.05), have comparability. All patients, while carrying out chemicotherapy treatment, take other drug and carry out auxiliary treatment. Wherein experimental group takes gained medicine of the present invention, instructions of taking: every day three times, each 6-8 ball, and warm water takes, 20 days courses for the treatment of. Observe altogether and treat four courses for the treatment of. Matched group takes other drug (such as conventional medicines such as XIHUANG WAN, anticancer pill ball, XIAOAIPING TANGJIANG).
1.3 curative effect determinate standards
Effective: mass reduction, clinical symptoms greatly improves, and within more than 2 years, lump does not increase;
Take a turn for the better: lump stops increasing, and clinical symptoms has and alleviates;
Invalid: solid tumor mass continues to increase, and clinical symptoms increases the weight of.
Effective percentage=(effective number of cases+improvement number of cases)/total inspection case load × 100%.
1.4 therapeutic outcomes
Result is as shown in table 1.
Table 1: the therapeutic outcome of experimental group and matched group patient
Therapeutic effect: effective 149 examples (71.6%), 52 examples that take a turn for the better (25%), invalid 7 examples (3.4%), effective percentage 96.6%. Experimental group therapeutic effect is substantially better than matched group.
The present invention is prepared from by the totally 15 taste primary raw material medicines such as popcorn, Fructus Mali Asiaticae, Herba Epimedii, Rhizoma Tupistrae Wattii, Fructus Elaeagni, Rhizoma Phyllostachydis henonis and Haematitum. Fang Zhong, popcorn has effect of depressed liver-energy dispersing and function of gallbladder promoting; Fructus Mali Asiaticae therapeutic method to keep the adverse QI flowing downwards the chest stuffiness relieving, relieving pain by regulating middle-JIAO; Herba Epimedii clearing away heat-damp and promoting diuresis; Fructus Elaeagni convergence pain relieving; Rhizoma Phyllostachydis henonis clearing heat and relieving fidgetness; Haematitum suppressing the hyperactive liver town is inverse; Caulis et Folium Brassicae capitatae eliminating damp-heat, removing obstruction for relieving pain; Fructus solani xanthocarpi repercussive pain relieving; Radix Gossampini heat-clearing and toxic substances removing; Break cool the blood dissipate blood stasis by a fall.All medicine compatibilities, bring out the best in each other, and play expelling wind and removing dampness, heat-clearing and toxic substances removing, the merit of removing obstruction for relieving pain altogether. Treating four courses for the treatment of, experimental group effective percentage is 96.6%, and therapeutic effect is safe and effective.
It should be pointed out that, the detailed description of the invention more representational example that is the present invention, it is clear that technical scheme is not limited to above-described embodiment, it is also possible to have many variations. Those of ordinary skill in the art, with the present invention undoubted the obtaining of clearly disclosed or according to file written description, be all considered as this patent scope of the claimed.
Claims (10)
1. the preparation taken during Gallbladder Carcinoma Patients chemicotherapy, it is characterised in that be prepared from by following bulk drugs, be weight portion: popcorn 8-15; Fructus Mali Asiaticae 5-8; Herba Epimedii 4-9; Rhizoma Tupistrae Wattii 0.5-1.8; Fructus Elaeagni 3-7; Rhizoma Phyllostachydis henonis 8-11; Haematitum 1-2; Herba Zebrinae Pendulae 0.8-1.8; Caulis et Folium Brassicae capitatae 3-5; Fructus solani xanthocarpi 10-16; Radix grewiae bilobae 6-9; Break 7-12 by a fall; Radix Gossampini 5-11; Herba arenariae kansuensis 6-10; Zijin sand 4-7.
2. the preparation taken during Gallbladder Carcinoma Patients chemicotherapy as claimed in claim 1, it is characterised in that be prepared from by following bulk drugs, be weight portion: popcorn 10-13; Fructus Mali Asiaticae 6-7; Herba Epimedii 5-8; Rhizoma Tupistrae Wattii 0.9-1.4; Fructus Elaeagni 4-6; Rhizoma Phyllostachydis henonis 9-10; Haematitum 1.3-1.7; Herba Zebrinae Pendulae 1.1-1.5; Caulis et Folium Brassicae capitatae 3.5-4.5; Fructus solani xanthocarpi 12-14; Radix grewiae bilobae 7-8; Break 9-10 by a fall; Radix Gossampini 7-9; Herba arenariae kansuensis 7-9; Zijin sand 5-6.
3. the preparation taken during Gallbladder Carcinoma Patients chemicotherapy as claimed in claim 1, it is characterised in that be prepared from by following bulk drugs, be weight portion: popcorn 11.5; Fructus Mali Asiaticae 6.5; Herba Epimedii 6.5; Rhizoma Tupistrae Wattii 1.2; Fructus Elaeagni 5; Rhizoma Phyllostachydis henonis 9.5; Haematitum 1.5; Herba Zebrinae Pendulae 1.3; Caulis et Folium Brassicae capitatae 4; Fructus solani xanthocarpi 13; Radix grewiae bilobae 7.5; Break 9.5 by a fall; Radix Gossampini 8; Herba arenariae kansuensis 8; Zijin sand 5.5.
4. the preparation method of the preparation pill taken during the Gallbladder Carcinoma Patients chemicotherapy as described in as arbitrary in claim 1-3, it is characterised in that step is as follows:
(1) Fructus solani xanthocarpi and Fructus Mali Asiaticae mixing, mix thoroughly with rice wine, vexed 15-25 minute (preferably vexed 20 minutes), and being subsequently placed on tile intense fire dries, and smashs into fine powder to pieces, standby; Replacing Haematitum and smash into coarse grain to pieces, intense fire is calcined to and is popular in, and puts into and quenches once in white vinegar, takes out, is ground into fine powder, standby;
(2) popcorn, Herba Epimedii, Caulis et Folium Brassicae capitatae, Radix Gossampini and the mixing of Zijin sand, fully dry, pulverize into fine powder, standby;
(3) Herba Zebrinae Pendulae is placed in medicine pot, spray Sucus Zingberis, slow fire stir-fries 3-7 minute (preferred slow fire stir-fries 5 minutes), take out, with Fructus Elaeagni, Rhizoma Tupistrae Wattii, Rhizoma Phyllostachydis henonis, Radix grewiae bilobae, break by a fall and Herba arenariae kansuensis is together placed in frying pan, add the clear water (preferably adding the clear water of 7.5 times amount) of 6-9 times amount, slow fire boiling 30-60 minute (preferred slow fire boiling 45 minutes), filtering, filtrate reduced in volume becomes thick paste, standby;
(4) step (1) and (2) gained fine powder are joined in step (3) gained thick paste, mixing, make the pill of Semen Firmianae size, to obtain final product.
5. the preparation method of the preparation pill taken during Gallbladder Carcinoma Patients chemicotherapy according to claim 4, it is characterized in that, in step (1), the amount of rice wine is described raw material dose 0.28-0.46 times (amount of preferred rice wine is 0.34-0.4 times of described raw material dose, it is more preferable to measuring of rice wine be 0.37 times of described raw material dose).
6. the preparation method of the formulation tablet taken during the Gallbladder Carcinoma Patients chemicotherapy as described in as arbitrary in claim 1-3, it is characterised in that step is as follows:
(1) replacing Haematitum and smash into coarse grain to pieces, intense fire is calcined to and is popular in, and puts into and quenches once in white vinegar, takes out, is ground into fine powder, standby;
(2) Herba Zebrinae Pendulae and Rhizoma Tupistrae Wattii mixing, add the Chinese liquor (being preferably added to the Chinese liquor of 4 times amount) of 3-5 times amount, and room temperature lower seal soaks 12-20 hour (preferred room temperature lower seal soaks 16 hours), take out, be placed in medicine pot, slow fire fried dry, take out, be ground into fine powder, standby;
(3) surplus stock medicine is together ground to form coarse powder, add the ethanol that concentration is 65%, reflux, extract, twice, respectively extract 18-36 minute (preferably each each extraction 27 minutes) every time, merge twice extracting solution, filter, filtrate recycling ethanol, concentrating under reduced pressure becomes thick paste, spray drying to get dry extract powder, standby;
(4) step (1) and step (2) gained fine powder are mixed with step (3) gained dried cream powder, add the magnesium stearate that mass fraction is 2.1% and the dextrin fine powder that mass fraction is 4.5%, mixing, sieve, be pressed into tablet, to obtain final product.
7. the preparation method of the formulation tablet taken during Gallbladder Carcinoma Patients chemicotherapy according to claim 6, it is characterized in that, in step (3), the amount of ethanol is coarse powder amount 7.5-10.5 times (amount of preferred ethanol is 8.5-9.5 times of coarse powder amount, it is more preferable to measuring of ethanol be 9 times of coarse powder amount).
8. the preparation method of the formulation tablet taken during Gallbladder Carcinoma Patients chemicotherapy according to claim 6, it is characterised in that step (4) is crossed 120-160 mesh sieve (preferred cross 130-150 mesh sieve, it is more preferable to mistake 140 mesh sieve).
9. the preparation method of the preparation water preparation taken during the Gallbladder Carcinoma Patients chemicotherapy as described in as arbitrary in claim 1-3, it is characterised in that step is as follows:
(1) replacing Haematitum and smash into coarse grain to pieces, intense fire is calcined to and is popular in, and puts into and quenches once in white vinegar, takes out, and is ground into fine powder, crosses 40-80 mesh sieve (preferred mistake 60 mesh sieve), standby;
(2) Herba Zebrinae Pendulae and Rhizoma Tupistrae Wattii mixing, add the Chinese liquor (being preferably added to the Chinese liquor of 4 times amount) of 3-5 times amount, and room temperature lower seal soaks 12-20 hour (preferably seal and soak 16 hours), takes out, standby; Herba Epimedii being chopped up silk, pours in the Oleum Sesami made popular, slow fire is fried to slightly yellow, takes out, standby;
(3) crude drug and popcorn, Fructus Mali Asiaticae, Fructus Elaeagni, Rhizoma Phyllostachydis henonis, Caulis et Folium Brassicae capitatae, Fructus solani xanthocarpi, Radix grewiae bilobae after step (2) being processed, break by a fall, Radix Gossampini, Herba arenariae kansuensis and Zijin sand are together placed in frying pan, add clear water and do not have powder 3-5cm, first intense fire heated and boiled 2-6 minute (preferred intense fire heated and boiled 4 minutes), it is subsequently adding the Haematitum after step (1) processes, turn slow fire boiling 40-70 minute (preferably turning slow fire boiling 60 minutes), filtering, filtrate is standby;
(4) by step (3) gained filtrate reduced in volume to the 1/2 of original volume, filtering through double-deck cotton cloth, sterilizing encapsulates, and to obtain final product.
10. the preparation method of the preparation granules agent taken during the Gallbladder Carcinoma Patients chemicotherapy as described in as arbitrary in claim 1-3, it is characterised in that step is as follows:
(1) replacing Haematitum and smash into coarse grain to pieces, intense fire is calcined to and is popular in, and puts into and quenches once in white vinegar, takes out, is ground into fine powder, standby;
(2) popcorn, Radix Gossampini and Herba Epimedii being mixed, add the Mel (being preferably added to the Mel of 0.65 times amount) of 0.5-0.8 times amount, mix thoroughly, slow fire stir-fries to tack-free and takes out for spending, and dries, smashs into fine powder to pieces, standby;
(3) Fructus Elaeagni, Fructus Mali Asiaticae and Fructus solani xanthocarpi mixing, be placed in medicine cookeding pot, and mild and heavy respiration alternately stir-fries to medical material cracker, then sprays yellow wine, continues slow fire and stir-fries 6-10 minute (preferably continuing to slow fire stir-fry 8 minutes), and taking-up cools, and smashs into fine powder to pieces, standby;
(4) surplus stock medicine is placed in baker fully dry, it is ground into fine powder, mix with step (1)-(3) gained fine powder, add mass fraction be 1.9% hydroxypropyl cellulose and mass fraction be 3% sucrose fine, mixing, cross 90-130 mesh sieve (preferred mistake 110 mesh sieve), make bead dosage form according to the processing mode of granule, to obtain final product.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104189675A (en) * | 2014-08-24 | 2014-12-10 | 刘杰 | Traditional Chinese medicine preparation for treating reoccurrence after gallbladder carcinoma operation |
| CN105012760A (en) * | 2015-08-18 | 2015-11-04 | 李苓 | Traditional Chinese medicine for relieving and treating gallbladder carcinoma |
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2016
- 2016-02-24 CN CN201610098586.9A patent/CN105663830A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104189675A (en) * | 2014-08-24 | 2014-12-10 | 刘杰 | Traditional Chinese medicine preparation for treating reoccurrence after gallbladder carcinoma operation |
| CN105012760A (en) * | 2015-08-18 | 2015-11-04 | 李苓 | Traditional Chinese medicine for relieving and treating gallbladder carcinoma |
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| Title |
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| 邬继云等: "胆囊癌术后化疗配合中药调理临床观察", 《中华中医药学刊》 * |
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Address after: Lotus Road Wanxiu District of Wuzhou city the Guangxi Zhuang Autonomous Region 543000 No. 34 No. 2 Building 1 unit 202 Applicant after: Wang Qiguang Address before: 250000 No. 15 normal road, Tianqiao District, Shandong, Ji'nan Applicant before: Wang Qiguang |
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