Embodiment
Present disclosure can be more easily understood with reference to the detailed description of following the preferred embodiment of the present invention and the embodiment that comprises. To mention a large amount of terms in following specification sheets and claim book, these terms are defined as following meanings.
" optional " or " optionally " refers to that the event described thereafter or item can occur or do not occur, and this description comprises situation and the situation that do not occur of event that event occurs.
Approximate term in specification sheets and claim book is used for modifying quantity, represents that the present invention is not limited to this concrete quantity, also comprises close to this quantity acceptable and can not cause the part of the correction of the change of relevant basic function. Accordingly, modify a numerical value with " approximately ", " about " etc., mean and the invention is not restricted to this accurate numerical value. In some example, approximate term may corresponding to the precision of the equipment measuring numerical value. In present specification and claim book, scope limits and can combine and/or exchange, if not illustrating that these scopes comprise contained all sub-scope therebetween in addition.
Term as used herein " by ... preparation " and " comprising " synonym. Term used herein " comprises ", " comprising ", " having ", " containing " or its other distortion any, it is intended to cover the comprising of non-exclusionism. Such as, comprise the composition of listed elements, step, method, goods or device and need not be only limitted to those key elements, but other key element clearly do not listed or the intrinsic key element of this kind of composition, step, method, goods or device can be comprised.
Conjunction " by ... composition " get rid of any key element, step or the component do not pointed out. If for, in claim, this phrase will make claim be closed so that it is do not comprise the material except those materials described, but except relative conventional impurity. When phrase " by ... composition " appears in the clause of claim main body instead of immediately preceding after theme time, its key element being only limited in this clause to describe; Other key element is not excluded outside described claim as a whole.
During the Range Representation that equivalent, concentration or other value or parameter limit with scope, preferable range or a series of upper limit preferred value and lower preferable values, this is appreciated that all scopes specifically disclosing and being formed by arbitrary pairing of any scope upper limit or preferred value and any scope lower limit or preferred value, no matter and whether this scope separately discloses.Such as, when disclosing scope " 1 to 5 ", described scope should be interpreted as comprising scope " 1 to 4 ", " 1 to 3 ", " 1-2 ", " 1-2 and 4-5 ", " 1-3 and 5 " etc. When numerical range is described herein, unless otherwise indicated, otherwise this scope intention comprises its end value and all integers within the scope of this and mark.
In addition, the quantity of key element or component is required (i.e. occurrence number) unrestriction by indefinite article " one " before key element of the present invention or component and " one ". Therefore " one " or " one " should be read as and comprise one or at least one, and the key element of odd number form or component also comprise plural form, unless the obvious purport of described quantity refers to odd number form.
In the present invention, the molecular-weight average of regulation is the molecular weight calculated by the limiting viscosity of test portion. In the present invention, adopt and obtain limiting viscosity by kinematic viscosity, this limiting viscosity is scaled the method for molecular weight, obtains molecular-weight average. , it may also be useful to the determination of ubbelohde viscometer kinematic viscosity illustrated below, more specifically, in the method obtain limiting viscosity by the value of this kinematic viscosity, this limiting viscosity is scaled molecular-weight average.
Generally, in order to obtain the limiting viscosity of test portion, first, prepare multiple sample solution, by the sample solution of Ubbelohde viscometer flow down number of seconds and solvent flow down number of seconds, based on following formula (1) and formula (2), calculate specific viscosity and reduced viscosity.
Formula (1)
Formula (2)
Secondly, for each sample solution, taking the reduced viscosity that obtains as the longitudinal axis, mark and draw taking the test portion concentration of dried object conversion as transverse axis and make calibration curve, by above-mentioned test portion concentration is extrapolated to 0, obtain the limiting viscosity of test portion. When test portion is hyaluronic acid, according to following formula (3), it is possible to obtain molecular-weight average M by the limiting viscosity of test portion.
Formula (3)
(in above-mentioned formula (3), k '=0.036, α=0.78).
Secondly, the measuring method for the kinematic viscosity becoming index when obtaining above-mentioned molecular-weight average is described.
Above-mentioned kinematic viscosity, it is possible to use Ubbelohde viscometer to measure. Now, select to flow down the Ubbelohde viscometer that number of seconds is the coefficient of 200-1000 second. In addition, it is determined in the Water Tank with Temp.-controlled of 30 ° of C to carry out so that temperature-resistantization.
By the product of the coefficient flowing down number of seconds and Ubbelohde viscometer of the aforesaid liquid adopting determination of ubbelohde viscometer, it is possible to obtain kinematic viscosity (unit: mm2/s)。
A kind of environmental protection nutritional type women's private portion conditioning liquid, with parts by weight, at least comprises following component:
N-acyl amino acid surfactant 35-55 part;
Nanometer silver 0.01-0.1 part;
Nanometer Margarita powder 0.1-0.5 part;
Nano-tourmaline 0.02-0.1 part;
Moisturizing composition 1-3 part;
Moisture-keeping composition 10-30 part;
Nanometer pollen 1-2 part;
100 parts, water;
The one that amino acid in described N-acyl amino acid surfactant is selected from neutral amino acids or acidic amino acid, described moisturizing composition comprises hyaluronic acid, collagen protein, and described moisture-keeping composition comprises Aloe oil, glycerine.
As a kind of preferred technical scheme of the present invention, the weight ratio of described moisturizing composition and moisture-keeping composition is 1:10.
N-acyl amino acid surfactant
Compared with fatty acid tensio-active agent, by inserting between alkyl and carboxyl, 1-CONHCHR-(R is amino acid whose side chain) base is formed N-acylamino acid. Its character changes with amino acid whose side chain difference, and when inserting amino, the acid increase of carboxylic acid, its soap aqueous solution turns into neutrality by weakly alkaline. The solubleness of its alkaline earth salt increases, and also has good foam performance in hard water. When with, time in the treatment of skin, skin being made to have lubrication sense. Amine key has the character forming intermolecular strong hydrogen bonding, in aqueous intermolecular in conjunction with time, state of aggregation can be affected.
N-acylamino acid has physiologically active; such as the milk-acid bacteria causing carious tooth is had Antibiotic activity by N-Sarkosyl L salt; rice blast pathogen is had Antibiotic activity by N-lauroyl α-amino-isovaleric acid, and the phage of interference amino acid fermentation is had antibiosis by N-oleic acid acyl glutaminate.
As a kind of technical scheme of the present invention, N-acyl amino acid surfactant is selected from N-acyl group peptide salt. The raw material of preparation N-acyl group peptide salt can be collagen protein. Collagen is the fibrous solids protein forming animal skeleton, skin, tendon etc., it does not have antibiosis, it may also be useful to safety. Collagen through appropriateness hydrolysis, forms the peptide that molecular weight is 400-2000, then carries out acidylate with chlorination coco-nut oil fatty acid, then neutralize and obtain N-acyl group peptide salt with potassium hydroxide in alkaline medium and under enzyme existence through gelatin.
As a kind of technical scheme of the present invention, N-acyl amino acid surfactant is selected from N-acyl sarcosinate.
As a kind of technical scheme of the present invention, N-acyl amino acid surfactant is selected from N-acyl-N-methyl-b-aminopropionate.
As a kind of technical scheme of the present invention, N-acyl amino acid surfactant is selected from N-acyl glutamate. Having 2 carboxyls in N-acyl glutamic acid molecule, owing to degree of neutralization is different, its character has very big difference. When a carboxyl is neutralized, another carboxyl exists with unbound state in aqueous, makes the aqueous solution be slightly acidic.
As a kind of technical scheme of the present invention, N-acyl amino acid surfactant is selected from lipid and the acid amides of N-acylamino acid.
As a kind of technical scheme of the present invention, N-acyl amino acid surfactant is selected from higher alcohols amino acid ester. The ester that such as neutral L-Ala and higher alcohols generate is cats product, soluble in water, has good surfactivity and foaming power.
As a kind of preferred technical scheme of the present invention, the structural formula of described N-acylamino acid is:
,
R1For the alkyl containing 3-29 carbon atom, R2For hydrogen atom or the substituting group containing 1-20 carbon atom, X1For the one in hydrogen atom, basic metal, alkaline-earth metal, ammonium, alkanolamine residue, N-alkyl tauride.
R1Can be saturated aliphatic hydrocarbon base, include but not limited to propyl group, sec.-propyl, normal-butyl, isobutyl-, sec-butyl, the tertiary butyl, n-pentyl, 1-methyl butyl, 2-methyl butyl, 3-methyl butyl, 1-ethyl propyl, 1,1-dimethyl propyl, 1,2-dimethyl propyl, 2,2-dimethyl propyl, just own base, 1-methyl amyl, 2-methyl amyl, 3-methyl amyl, 4-methyl amyl, 1-ethyl-butyl, 2-ethyl-butyl, 1,1-dimethyl butyl, 1,2-dimethyl butyl, 1,3-dimethyl butyl, 2,2-dimethyl butyl, 2,3-dimethyl butyl, 3,3-dimethyl butyl, 1,1,2-thmethylpropyl, 1,2,2-thmethylpropyl, n-heptyl, the own base of 1-methyl, the own base of 2-methyl, the own base of 3-methyl, the own base of 4-methyl, the own base of 5-methyl, 1-ethyl pentyl group, 2-ethyl pentyl group, 3-ethyl pentyl group, 1,1-dimethyl amyl group, 1,2-dimethyl amyl group, 1,3-dimethyl amyl group, 1,4-dimethyl amyl group, 2,2-dimethyl amyl group, 2,3-dimethyl amyl group, 2,4-dimethyl amyl group, 3,3-dimethyl amyl group, 3,4-dimethyl amyl group, 4,4-dimethyl amyl group, 1,1,2-trimethyl butyl, 1,1,3-trimethyl butyl, 1,2,2-trimethyl butyl, 1,2,3-trimethyl butyl, 1,3,3-trimethyl butyl, 2,2,3-trimethyl butyl, 2,3,3-trimethyl butyl, octyl group, nonyl, the last of the ten Heavenly stems base, undecyl, lauryl, tridecyl, myristyl, pentadecyl, palmityl, pearly-lustre fat base, stearyl, nonadecyl, peanut base, mountain Yu base, wood wax base, wax base, nonacosyl.
R1It can also be saturated cyclic, include but not limited to cyclopentyl, cyclohexyl, 2-methylcyclopentyl, 3-methylcyclopentyl, suberyl, 2-methyl cyclohexane base, 3-methyl cyclohexane base, 4-methyl cyclohexane base, 2-ethylcyclopentyl, 3-ethylcyclopentyl, ring octyl group, 2-methyl suberyl, 3-methyl suberyl, 4-methyl suberyl, 2,2-Dimethylcyclohexyl, 2,3-Dimethylcyclohexyl, 2,4-Dimethylcyclohexyl, 3,3-Dimethylcyclohexyl, 3,4-Dimethylcyclohexyl, 4,4-Dimethylcyclohexyl.
R1Can also be unsaturated alkyl, include but not limited to 2-propenyl, 1-propenyl, 1-butylene base, crotyl, 3-butenyl, 1-methyl isophthalic acid-propenyl, 1-methyl-2-propenyl, 2-methyl isophthalic acid-propenyl, 2-methyl-2-propenyl, 1-pentenyl, pentenyl, 3-pentenyl, 4-pentenyl, 1-methyl isophthalic acid-butenyl, 1-methyl-2-butene base, 1-methyl-3-butenyl, 2-methyl-1-butene alkene base, 2-methyl-2-butene base, 2-methyl-3-butenyl, 3-methyl-1-butene base, 3-methyl-2-butene base, 3-methyl-3-butenyl, 1,2-dimethyl-1-propenyl, 1,1-dimethyl-2-propenyl, 1,2-dimethyl-2-propenyl, 1-hexenyl, 2-hexenyl, 3-hexenyl, 4-hexenyl, 5-hexenyl, 1-Methyl-1-pentene base, 1-methyl-pentenyl, 1-methyl-3-pentenyl, 1-methyl-4-pentenyl, 2-Methyl-1-pentene base, 2-methyl-pentenyl, 2-methyl-3-pentenyl, 2-methyl-4-pentenyl, 3-Methyl-1-pentene base, 3-methyl-pentenyl, 3-methyl-3-pentenyl, 3-methyl-4-pentenyl, 4-methyl-1-pentene base, 4-methyl-pentenyl, 4-methyl-3-pentenyl, 4-methyl-4-pentenyl, 1-ethyl-1-butylene base, 1-ethyl-crotyl, 1-ethyl-3-butenyl, 2-ethyl-1-butylene base, 2-ethyl-crotyl, 2-ethyl-3-butenyl, 1,1-dimethyl-crotyl, 1,1-dimethyl-3-butenyl, 1,2-dimethyl-1-butylene base, 1,2-dimethyl-crotyl, 1,2-dimethyl-3-butenyl, 1,3-dimethyl-1-butylene base, 1,3-dimethyl-crotyl, 1,3-dimethyl-3-butenyl, 2,2-dimethyl-3-butenyl, 2,3-dimethyl-1-butylene base, 2,3-dimethyl-crotyl, 2,3-dimethyl-3-butenyl, 2-methyl isophthalic acid-cyclopentenyl, 3-methyl isophthalic acid-cyclopentenyl, 4-methyl isophthalic acid-cyclopentenyl, 5-methyl isophthalic acid-cyclopentenyl, 2-methyl-2-cyclopentenyl, 3-methyl-2-cyclopentenyl, 4-methyl-2-cyclopentenyl, 5-methyl-2-cyclopentenyl, 2-methyl-3-cyclopentenyl, 3-methyl-3-cyclopentenyl, 4-methyl-3-cyclopentenyl, 5-methyl-3-cyclopentenyl, 1-cyclohexenyl, 2-cyclohexenyl, 3-cyclohexenyl, α-flax base, stearidonic base, eicosa-pentaenoic base, two dodecahexaene bases, sub-oil base, conjugation sub-oil base, γ-flax base, 20 carbon trialkenyl, arachidonic base, oil base, eicosylene base, 20 carbon trialkenyl, mustard base.
As a kind of preferred technical scheme of the present invention, at least one that wherein acyl group in N-acylamino acid is selected from lauroyl, cocoyl, myristoyl, palmitoyl, pearly-lustre fatty acyl group, stearyl-, different stearyl-, peanut acyl group, mountain Yu acyl group, wood wax acyl group, wax acyl group, melissa acyl group, fatty acid distribution of coconut oil acyl group, palm oil fatty acid acyl group, palm kernel fatty acid acyl group, tallow fatty acids acyl group and hardening tallow fatty acids acyl group.
R2Can be hydrogen atom, it is also possible to be hydrocarbyl substituent, include but not limited to methyl, ethyl, propyl group, sec.-propyl, normal-butyl, isobutyl-, sec-butyl, the tertiary butyl, n-pentyl, 1-methyl butyl, 2-methyl butyl, 3-methyl butyl, 1-ethyl propyl, 1,1-dimethyl propyl, 1,2-dimethyl propyl, 2,2-dimethyl propyl, just own base, 1-methyl amyl, 2-methyl amyl, 3-methyl amyl, 4-methyl amyl, 1-ethyl-butyl, 2-ethyl-butyl, 1,1-dimethyl butyl, 1,2-dimethyl butyl, 1,3-dimethyl butyl, 2,2-dimethyl butyl, 2,3-dimethyl butyl, 3,3-dimethyl butyl, 1,1,2-thmethylpropyl, 1,2,2-thmethylpropyl, octyl group, nonyl, the last of the ten Heavenly stems base, undecyl, lauryl, tridecyl, myristyl, pentadecyl, palmityl, pearly-lustre fat base, stearyl, nonadecyl, peanut base, mountain Yu base, wood wax base, wax base, nonacosyl, α-flax base, stearidonic base, eicosa-pentaenoic base, two dodecahexaene bases, sub-oil base, conjugation sub-oil base, γ-flax base, 20 carbon trialkenyl, arachidonic base, oil base, eicosylene base, 20 carbon trialkenyl, mustard base.
R2Can also be the substituting group containing elements such as oxygen, nitrogen, sulphur, include but not limited to methylene radical p-hydroxybenzene, acetoxyl, Padil base, propionyloxy, propionamido-, methylthio group ethyl, methylol, hydroxyethyl, 1-hydroxyethyl, thiopurine methyltransferase, mercapto ethyl.
As a kind of preferred technical scheme of the present invention, at least one that the amino acid in described N-acylamino acid is selected from phenylalanine, methionine(Met), Threonine, Isoleucine, leucine, α-amino-isovaleric acid, L-Ala, tyrosine, norvaline, aspartic acid, Serine, homoserine, halfcystine, homocysteine, selenocystein, homocystine, Gelucystine, L-glutamic acid, glycine, homoisoleucine, nor-leucine.
X1Can be hydrogen atom, it is also possible to be basic metal, such as: sodium, potassium. X1Can also be alkaline-earth metal, such as: magnesium, calcium. X1Can also being ammonium salt, it is also possible to be alkanolamine residue, wherein alkanolamine can list such as methyl alcohol amine, dimethanolamine, trimethanolamine, thanomin, diethanolamine, trolamine, propyl alcohol amine, dipropanolamine, tripropanol amine. X1Can also being N-alkyl tauride, its alkyl can be methyl, ethyl, propyl group, sec.-propyl, and salt can be ammonium salt, sodium salt, sylvite, magnesium salt, calcium salt, diethanolamine salt, triethanolamine salt. Above about X1Enumerate and be only illustration, be not limited to cited material.
Using water as 100 weight parts, the content of described N-acyl amino acid surfactant is 35-55 weight part.
Nanometer silver
Owing to nanometer silver has great specific surface area, can dissociateing silver ions in aqueous, the sterilizing mechanisms of nanometer silver is similar with silver ions, but the effective concentration of nanometer silver and silver ions is completely different. The particle diameter of nanometer silver is more little, and perviousness is more strong, and bactericidal property is more strong. The size of nano-Ag particles is less, can entering pathogenic agent easily, zymoprotein matter sulfydryl is combined rapidly in thalline, makes some lose vigor as the enzyme of necessary group, make pathogenic bacterium can not metabolism and dead, thus reach the effect of sterilization, repair tissue, promotion wound healing. Nanometer silver can be combined with DNA of pathogenic base and form cross connection, replaces the hydrogen bond between adjacent nitrogen in purine and pyrimidine, and bacterium DNA replication ability is lost, and protein inactivation, causes pathogenic bacterium inactivation.Nanometer silver can also with the amino in bacterium, carboxyl reaction, reach the effect of kill bacteria or mould. Nanometer silver can kill streptococcus aureus, intestinal bacteria, Pseudomonas aeruginosa, Candida albicans, streptococcus pyogenes, faecalis, chlamydia trachomatis, gonococcus etc.
Nanometer silver can kill multiple harmful germ as New-type wide-spectrum sterilant within the short period of time, does not produce any resistance. And perviousness is strong, it is possible to penetrate into subcutaneous from the pore of skin, common bacteria, stubborn bacteria, resistant organism and very microbial infection had good germicidal action. Nanometer silver can also promote wound healing, improves the blood circulation of wound surrounding tissue, it is possible to promotes tissue cell growth, accelerating wound healing, reduces the generation of scar.
The size of described nanometer silver is 1-20nm, it is preferable to 1-10nm. .
The preparation of nanometer silver can adopt physico-chemical processes and chemical reduction method. Physico-chemical processes is divided into photon reduction method, laser lift-off, high-pressure magnetic sputtering method, ultrasonic method; Chemical reduction method comprises silver-amino coordination ion reduction method, electrochemical reducing, reverse micelle method.
Photon reduction method prepares a kind of important method of nanometer silver, its ultimate principle makes solution produce hydrated electron and go back the free radical group of prototype by illumination, hydrated electron or free radical group can silver ionss in reducing solution, form activation silver, activation silver is accumulated into larger particles continuously, then with high molecular polymer or other media stabilize particles, the circulation ratio preparing nanometer silver by this method is better, and it is at room temperature carry out, also not by the interference of the impurity that may introduce. The reduction process of photon reduction method is homogeneous reaction, there is not the problem that partial concn is excessive. In addition, it is possible to produce hydrated electron by UV-irradiation or go back prototype free radical group.
Laser lift-off preparation process is as follows, and silver foil is placed on the bottom of Glass Containers, adds the solution of 10 milliliters of tensio-active agents (such as sodium lauryl sulphate or sodium laurylsulfonate), and solvent can be water, butanols, hexane etc. Producing, with laser focusing lens, the second harmonic that wavelength is 532nm and irradiate silver foil, pulse width is 10ns, and repetition rate is 10Hz. By the spot size of the distance adjustment laser light beam between change lens and silver foil to 1-3mm. After laser illumination silver foil, plasma body can be generated, make silver foil be converted into nano-scale particle. Then by centrifugal, extract by decant method.
High-pressure magnetic sputtering method needs rare gas element (such as helium, argon, krypton) atmosphere, and gas pressure intensity maintains between 3mtorr 1torr, and sputtering source can adopt direct supply, and axial length is about 200mm, and planar diameter is about 50mm, peak power output moon 1kw. Sputtering voltage can be about 350V. When forming stable plasma body, the nano-Ag particles that sputtering obtains can be collected the copper substrate cooled with liquid nitrogen instrument and obtain. The distance of substrate and sample is about 5.5cm.
Ultrasonic method uses the ultrasonic Ag containing tensio-active agent (such as sodium lauryl sulphate, Sodium dodecylbenzene sulfonate, polyvinylpyrrolidone, Tween-20, polyethylene glycol mono stearate etc.) of ultrasonic generator+Solution, Ag+It is reduced and obtains nano level Argent grain.
Silver-amino coordination ion reduction method adds strong aqua to silver nitrate aqueous solution, then drip and add hydrogen peroxide, can make nano-Ag particles, react as follows:
2Ag(NH3)2 ++H2O2+2OH-=2Ag+O2+4NH3+2H2O
Reaction carries out at low temperatures, grain growth can not occur, Argent grain system easy to control in size because of high temperature, and Granularity Distribution is narrower, also compares equal one.Another kind of method adds stablizer in silver-amino coordination ion solution, such as polyvinylpyrrolidone, alkyl sulfhydryl, oleic acid and palmitinic acid etc., is nano-Ag particles with xitix or hydrazine hydrate or sodium borohydride reduction silver-amino coordination ion. Finally more Manufactured nano-Ag particles is immersed in passivator, such as oleic acid, then oleic acid is filtered out, vacuum-drying, obtain nano-Ag particles. Nano-Ag particles good stability that this kind of method for making obtains, good dispersity.
Electrochemical reducing utilizes electrode reaction to prepare nano metal, the product rate height of this method, easily separated, and reaction process, without metal hydride or boron impurity, controls particle size by changing current density, and this method can make the Argent grain of 2-7nm. Dissolution of metals anode in aprotonic solvent, the nano-Ag particles made is pure.
Reverse micelle method prepares nanometer silver with colloid chemistry reduction silver ions. Reverse micelle refers to that surfactant dissolves is in organic solvent, when concentration exceedes micelle-forming concentration, forms hydrophilic radical inwardly, hydrophobic grouping particle outwardly. Reverse micelle kernel can form water core by solubilising water molecules, and the silver ions that reduces in water core forms nanoparticle. Such as: in reverse micelle, reduce Silver Nitrate with Xanthaurine, can be made into the Argent grain of 1-1.5nm. Can also at a-Al2O3Upper loaded with nano Argent grain, on stainless steel ware, inject silver ions after reduction, active carbon nanoparticles area load nanometer silver, on various fabric such as loaded with nano Argent grain on nylon-11, nylon-66, and on polypropylene non-woven fabric, on textile cloth fabric loaded with nano Argent grain.
Using water as 100 weight parts, the content of described nanometer silver is 0.01-0.1 weight part.
Nanometer Margarita powder
Since the dawn of human civilization, pearl signify rich, happy always, happiness and noble. Feudal society influential officials represent status, power, money and honorable identity with pearl, and the common people are with pearl symbol happiness, safety and luckiness. The medicine ancient books such as " Kaibao Bencao ", the Compendium of Material Medica of the Ming Dynasty of medical book " Mingyi Bielu " during three states, " book on Chinese herbal medicine is through the collection " in beam generation, " the sea medicine book on Chinese herbal medicine " of the Tang Dynasty, Song dynasty, " the Thunder God Yaoxing Fu " of the Qing Dynasty, all has clear and definite record to the curative effect of pearl. The Pharmacopoeia of the People's Republic of China, " Chinese medicine voluminous dictionary " all indicate, and pearl has arresting convulsion of calming the nerves, and bright order disappears screen, detoxify and promote granulation. For insomnia of palpitating with fear, infantile convulsion epilepsy, the raw cloud screen of order, sore is not held back.
The inorganic components massfraction of pearl accounts for more than 91%, and main body is aragonite and calcite, separately has a small amount of magnesite, is secondly silicon oxide, calcium phosphate, Al2O3And Fe2O3Deng. The main body of pearl organic composition is Chitosan-alginate microcapsules (also claiming keratoprotein or solid albumen) and various pigment. Organism in pearl contains 17 seed amino acids such as Aspartic Acid, Threonine, Serine, L-glutamic acid, glycine, L-Ala, Gelucystine, α-amino-isovaleric acid, methionine(Met), Isoleucine, leucine, tyrosine, phenylalanine, Histidine, arginine, proline(Pro). In addition, also containing 30 various trace elements, taurine, abundant VITAMIN, peptide class.
Pearl powder can improve the activity of human skin superoxide-dismutase (SOD), the synthesis of check melanin, keeps whitening skin. In addition, owing to SOD has the effect of scavenging free radicals, skin aging, wrinkling can be prevented. After being absorbed by the body, by participating in organism metabolism, reach overall conditioning and the maintenance of skin.It can promote that neonatal cell synthesizes, and constantly adds to skin surface, makes skin smooth, exquisiteness, flexible. In addition, pearl powder is all natural ingredients, by participating in the metabolism of cell DNA, can promote wound healing. The powder body of nanometer Margarita powder is finer and smoother invisible, simultaneously its good absorbing effect, it is to increase the utilization ratio of effective constituent.
The preparation method of nanometer Margarita powder can be enumerated as such as: is cleaned by pearl clean, dries. Then using medicinal herb grinder that pearl powder is broken into coarse meal, the particle diameter of coarse meal is between 80-1000mm. Being pulverized by thick pearl powder micronizer mill, obtain oyster pearl powder, particle diameter is between 0.5-10mm. By oyster pearl powder ultrasonic disperse in deionized water, pulverize with high-speed shearing machine. Nano grinder is used to be crushed to Nano grade after dry.
As a kind of preferred technical scheme of the present invention, the size of described nanometer Margarita powder is 200-800nm.
Using water as 100 weight parts, the content of described nanometer Margarita powder is 0.1-0.5 weight part.
Nano-tourmaline
Tourmalinite is also referred to as green imperial or royal seal, is a kind of silicate minerals containing boron, aluminium, sodium, iron, lithium. Its chemical structure can represent for XY3Z6(T6O18)(BO3)3V3, there is difference according to the different chemical formula in the place of production and mining area in W, wherein X is generally Na or Ca, or K, or vacancy. Y location is generally such as Li+、Mg2+、Fe2+、Mn2+、Al3+、Cr3+、V3+、Fe3+、Ti4+Deng multivalent state positively charged ion. Z location is Tricationic mainly, such as Al3+、Fe3+、Cr3+、V3+Deng, it is also possible to it is that divalent cation is such as Mg2 +、Fe2+Deng. T location is generally Si, but the difference according to the place of production also may be Al or B. When these uncertain element positions are by element substitutions such as Cr, V, Ti, Fe, Cu, tourmalinite just presents various distinct colors.
Tourmalinite has [Si6O18] multiple tripartite's ring structure, belong to trigonal system. Tourmalinite has piezoelectricity and pyroelectricity, when temperature and pressure change, can produce 1 × 10 between the lattice of tourmalinite6The potential difference of eV, this electrostatic field can make ionization of air, and that is hit is electronically attached to close water molecules and oxygen molecule, makes them be converted into negative aeroion. The tourmalinite specific surface area of Nano grade is very big, it is possible to produce a large amount of negative oxygen ion, and the perviousness of cell is also better, and the negative oxygen ion of generation can remove the free radical in human body, it is possible to delays senility. Tourmalinite another one advantage to radiate out the hertzian wave that wavelength is 4-14mm, and the wave frequency commensurate in scope that human body radiation goes out. Resonance will be produced when wave frequency mates mutually, the water molecule activation in human body can be made, the nutritive ingredient of other high molecular when acting on skin surface, can be made can to enter cell interior.
As a kind of preferred technical scheme of the present invention, the size of described nano-tourmaline is 50-100nm.
The method for making of nano-tourmaline can adopt mechanochemical reaction, is divided into dry method and wet method. Size distribution width prepared by dry method, uneven, energy consumption height, the even particle size distribution of wet-layer preparation, easily controls, but needs through dry, dispersion treatment. Tourmalinite split airflow milling can be crushed to 1mm, again with wet grinding, liquid phase medium adopts deionized water, propyl carbinol, ethanol, obtains slurry body, add grinding medium (if particle diameter is the zirconia ball of 1-3mm) to grind certain time afterwards, it is dried afterwards and dispersion treatment. Milling time is about 2h, and in slurry body, the quality of solid and the volume ratio of liquid are about 1:1, slurry body viscosity can be made to increase, cause grinding machine to grind smoothly when solid is more, and the particle diameter obtaining tourmalinite when solid is less is bigger.The selection of liquid phase medium also can affect size, and tourmalinite belongs to polarity particle, it is preferable that polarizable medium. During using water as liquid phase medium, the viscosity of sample is relatively big, and mobility is poor. Taking propyl carbinol, ethanol as the viscosity of the sample of liquid phase medium is low, good fluidity.
Using water as 100 weight parts, the content of described nano-tourmaline is 0.02-0.1 weight part.
Moisturizing composition
As a kind of preferred technical scheme of the present invention, described moisturizing composition is made up of hyaluronic acid and collagen protein.
The molecular-weight average of hyaluronic acid is 500,000-200 ten thousand, be present in organism in a large number numerous tissues (such as subcutis, eyeball, joint) polysaccharose substance. Its physiological function to make moisture enter intercellular substance; and form protein gelatin with protein bound; cell is bonded at together; the cellular metabolism effect brought into normal play, plays and keeps cell moisture, and Cell protection is not by the infringement of pathogenic bacteria; accelerate to recover skin histology; improving wound healing regenerative power, reduce scar, strengthening immunity etc. act on. In the present invention, hyaluronic acid refers to the polyose with the repeated structural unit that more than 1 is formed by the disaccharides of glucuronic acid and N-acetyl-glucosamine. Can also being hyaluronate, hyaluronate be not particularly limited, it will be preferred that pharmaceutically permissible salt, such as, it is possible to enumerate sodium salt, sylvite, calcium salt, zinc salt, magnesium salt, ammonium salt etc.
As long as the material that the hyaluronic acid this area used in the present invention generally uses, any material, can be from natural goodses such as animals, such as middle materials extracted such as the bio-tissues such as cockscomb, umbilical cord, skin, synovial fluid, such as, or culturing micro-organisms or zooblast and the material that obtains, the material etc. of the chemosynthesis such as fermentation method employing the bacterium etc. of streptococcus or enzymic synthesis all can use.
Collagen protein is the main component of skin corium, relevant with the elasticity maintaining skin, but due to age growth, the collagen protein amount of skin reduces, and the elasticity of skin is impaired, can promote formation or the skin aging of wrinkle. In addition, due to drying, stratum corneum and epidermal area are plump, when the stripping of stratum corneum is slow, then become shallow wrinkle. The collagen protein that the present invention uses is not particularly limited, it may also be useful to the material that collagen protein form is commercially available. The material from ox-hide, pigskin, fish-skin, fish scale, chicken skin etc. can be enumerated. There is no particular limitation for the molecular weight of collagen protein, it is contemplated that to the problem of solubleness and skin absorption, then molecular-weight average is 3000-100000Da.
Hyaluronic acid and collagen protein can be mutually promoted in the absorption of skin surface, the present inventor finds when the weight ratio of hyaluronic acid and collagen protein is 1:(50-100) time, collagen protein can be eliminated to the stimulation of skin, there will not be peculiar smell, precipitation to assemble, occur without allergic phenomena. And collagen protein improves membrane passage, it is possible to make the nutritive ingredient of more hyaluronic acids be absorbed by the skin.
As a kind of preferred technical scheme of the present invention, the weight ratio of described hyaluronic acid and collagen protein is 1:(50-100).
As a kind of preferred technical scheme of the present invention, the molecular-weight average of described hyaluronic acid is 50000-2200000Da.
Using water as 100 weight parts, the content of described moisturizing composition is 1-3 weight part.
Moisture-keeping composition
The present invention coordinates the use of moisture-keeping composition can suppress glutinous greasy, astringent, and has dense sense and the thoughts and feelings of water profit, has excellent use sense.Described wetting Agent for Printing Inks can be sucrose, Sorbitol Powder, glycerine, 1,3 butylene glycol, propylene glycol, the sucroses such as dipropylene glycol or polyalcohols, have polyvalent alcohol parent nucleus and propylene oxide 2-100 mole and oxyethane less than 50 moles addition polymerizations of the hydroxyl of more than 3 and the polyethers based compound that becomes, ethyl glucuronide alcohol polyethers-10 in molecule, chondroitin sulfate, hyaluronic acid, mucoitin sulfate, Carlow is rather sour, Atelocollagen albumen, cholesterol-12-hydroxy stearic acid ester, bile acide list salt, the single salt of pyrrolidone carboxylic acid, short chain soluble collagen, thorn pears extracting solution, Europe alpine yarrow extract, propylene glycol, dipropylene glycol, 1,3 butylene glycol, 1,4-butyleneglycol, Diethylene Glycol, triethylene glycol, the glycolss such as the polyoxyethylene glycol of its above molecular weight, glycerine, Glycerol dimer, the Polyglycerine class of its above molecular weight, Sorbitol Powder, mannitol, maltose alcohol, Xylitol, the sugar alcohols such as erythritol, fructose, glucose, semi-lactosi, maltose, lactose, the carbohydrates such as trehalose, polypropylene glycol/ethylene glycol copolymer or its dimethyl ether etc.
As a kind of preferred technical scheme of the present invention, described moisture-keeping composition is made up of glycerine and Aloe oil.
Glycerine is the most frequently used wetting Agent for Printing Inks in this area, but there is the shortcoming that moisture-retaining capacity is on the weak side.
The main component of Aloe oil is Aloe polysaccharide, protein, amino acid etc. Aloe oil is C12-C14Lipid acid is main crude vegetal, comprises 169 kinds of beneficiating ingredients that aloe is intrinsic, extensively for fields such as food, makeup, medicine, chemical industry, can have health care and beautification function that other grease cannot substitute. Wherein the saturated fatty acid in aloe composition accounts for 1/4th, comprises capric acid, lauric acid, tetradecanoic acid, pentadecylic acid, palmitinic acid, margaric acid, stearic acid. Unsaturated fatty acids accounts for 3/4ths, comprises Zoomeric acid, hexadecadienoic acid, oleic acid, linolic acid, linolenic acid. In addition also containing organic acids such as succsinic acid, oxysuccinic acid, lactic acid, P-coumaric acids. Aloe oil is because containing carotenoid and rhabarberone and derivative thereof, color is oyster turbid liquid, and main component is Mixed Fatty Glyceride, and oleic acid (OA) accounts for main integral part. Aloe oil is the mixture of triglyceride level etc., fusing point and zero pour is a temperature range, and generally between 40-50 ° of C, proportion is less than water, increases with molecular weight and reduces, and increases with degree of unsaturation and increases. The refractive index of Aloe oil increases with the increase of molecular weight, increases with double bond and raises. Conjugated double bond exists, and has higher refractive index than similar unconjugated double bond compound.
Aloe oil protects water xylogen containing natural gum material, has strong permeate substance, nutrient substance can be helped to penetrate into skin Chinese honey locust, has powerful cleaning, antimicrbial power effect, is natural saponin, has the effects such as anti-inflammatory, detumescence, bacteria growing inhibiting, antipruritic, pain relieving. There is moist moisturizing, whitening and speckle dispelling, the directly cosmetic result such as anti-ageing, hypo-allergenic. Play simultaneously and restrain skin surface pathogenic microorganism and bacterium, kill the mite worm that human body skin is harmful, prevent the breeding of superficial microbes, the generation of prevention tetter. Being applicable to oily skin, balance, suppression sebum secretion, promote wound healing.
β-carotene contained in Aloe oil can strengthen radiation and chemotherapy to the curative effect of tumour, and reduce them and pay effect to the poison of body, it is to increase the immunologic function of host.The effect of β-carotene prophylaxis of tumours and auxiliary oncotherapy is all closely related with antioxidation property. Containing multiple conjugated double bond in β-carotene, it it is a good antioxidant, therefore the function of detoxification of body can be improved, be conducive to carcinogens fast deactivation, the activation of carcinogens precursor also there is restraining effect, β-carotene can also quench free radicals and stop the generation of free radical, be similar to the effect of superoxide dismutase, can effectively suppress the lipid peroxidation that free radical causes.
Aloe oil and glycerine are used in combination as wetting Agent for Printing Inks, it is possible to obtain more permanent humidity-holding effect, coordinate moisturizing composition together, replenishing water and preserving moisture better effects if.
As a kind of preferred technical scheme of the present invention, the weight ratio of described Aloe oil and glycerine is 1:(40-100).
As a kind of preferred technical scheme of the present invention, the kinematic viscosity of described Aloe oil is 0.5-1.5mm2/s。
Using water as 100 weight parts, the content of described moisture-keeping composition is 10-30 weight part.
Nanometer pollen
As a kind of preferred technical scheme of the present invention, described nanometer of pollen is obtained through pulverizing by the flower of plant, at least one that described plant is selected from the Rosaceae, composite family, Liliaceae.
Breaking method can list such as: by the flower oven dry of plant, it may also be useful to LC6L-60L nanometer of horizontal sand mill grinds, and namely arrives.
As a kind of preferred technical scheme of the present invention, described nanometer of pollen is obtained through pulverizing by the flower of plant, at least one that described plant is selected from rose, chrysanthemum, lily.
Rose is Rosaceae gul, Compendium of Material Medica has record: " Rose; fragrance the denseest, turbid clearly and not and and liver not violent, soft wake up stomach, have a respite and blood ", " A Supplement to the Compendium of Materia Medica " is recorded: " Rose regulating and activating blood circulation, regulates the flow of vital energy, and controls wandering arthritis; fasting dysentery; acute mastitis, and swollen poison is from the beginning of, stomachache due to hyperactive liver-QI attacking the stomach. " research shows; containing compositions such as volatile oil (essence oil), soap glycosides, organic acid, polyatomic phenols in rose, its volatile oil (essence oil) comprises geraniol, Geraniol, vernol, phantol, phenylethyl alcohol, Eugenol, farnesol and ester class, sesquiterpene and derivative thereof etc. Rose is the long cosmetics and skincare product of a kind of applicating history, and it has the beauty functions such as whitening, control oil, convergence pore. Its moisturizing and nourishing effect, can make dry responsive skin recover water profit in time tender; The convergence of rose, the antibacterial and calmness effect of releiving, can suppress too much fat secretion, make skin exquisiteness pure and fresh, not bellding light; And rose is rich in the nutritive substance of the useful HUMAN HEALTH such as multivitamin, polyphenol, polysaccharide, amino acid, and there is the effect delayed senility, life-time service can make skin moisten and be rich in gloss. Meanwhile, nanometer rose powder can also play covering, painted, the effect that absorbs, sprawl.
Chrysanthemum is composite family chrysanthemum platymiscium, and " Bencao Jingshu " is recorded: " the autocratic wind wood of chrysanthemum, therefore for going the key medicine of wind. Hardship can expel the heat-evil, sweet can benefit blood, sweet detoxify, flat then double pungent, therefore also dissipating bind. " " medicineization justice " record: " its body is light, mildly bitter flavor for sweet chrysanthemum, extracting waste person, and property gas peace, to clear product. " chrysanthemum is containing volatile oil; composition is mainly borneol; camphor, chrysanthemum oil ring ketone, also containing luteolin-7 glycoside; cosmos glucoside and apigenin-7-O-glycoside; locust tree glucoside, apigenin, apigenin-7-O-sandlwood glycoside; robinin-7-O-glycoside Quercetin-3-O-galactoside, luteolin-7-O-sandlwood glycoside, luteolin-7-O-sandlwood glycoside, luteolin, b-Elemenum, thymol, heneicosane, tricosane, hexacosane, and carbohydrate and amino acid.Gram positive bacterium (streptococcus aureus and beta hemolytic streptococcus), Bacillus tuberculosis are had some restraining effect by chrysanthemum in vitro. Its water logging agent is to some common skin pathogenicity fungi also some restraining effect. Antiviral (PB8 strain) in addition in vitro and anti-spirochete effect.
Lily is Liliaceae lily, records in " Japan hanako materia medica ": " feeling at ease, determine courage, benefit will, supports the five internal organs. Control insane heresy crow position, mad cry, palpitation with fear, kills disease due to noxious agents produced by various parasites gas, and acute mastitis, carbuncle on the back and all sores are swollen, and the mad fortune of blood after managing property. " lily is containing lilium regale wilson glucoside A, D; 3; 6 '-O-two asafoetide acyl sucrose; 1-O-asafoetide acyl glycerine; the p-coumaric acyl glycerine of 1-O-; 26-O-β-D-glucopyranosyl-slave's Ah's sapogenin-3-O-α-L-rhamnopyranose base-(1 → 2)-β-D-glucopyanoside, 26-O-β-D-glucopyranosyl-slave's Ah's sapogenin-3-O-α-L-rhamnopyranose base-(1 → 2)-O-[β-D-glucopyranosyl (1 → 4)]-β-D-glucopyanoside.
Other
Environmental protection nutritional type women's private portion conditioning liquid of the present invention can also coordinate other additive as required, for its kind and use level, can be suitable for selecting in the scope of effect not damaging the present invention. As other additive, can list such as: spices, pigment, salt, pearling agent, tinting material, medicament, thickening material, UV light absorber, coagent, pH adjusting agent etc.
Using water as 100 weight parts, the content of other material is 1-5 weight part.
A preparation method for environmental protection nutritional type women's private portion as above conditioning liquid, comprises following steps:
(1) adding N-acyl amino acid surfactant, Aloe oil, glycerine, water in container A, heated and stirred is even;
(2) adding nano-tourmaline, nanometer silver, nanometer Margarita powder, nanometer pollen, water in container B, stirred at ambient temperature is even;
(3) mixture in container B is poured in container A, at room temperature adds hyaluronic acid, collagen protein successively, stirs filling after evenly, packaging.
Hereinafter, by embodiment, the present invention is explained in more detail, it should be appreciated that these embodiments only be illustrate but not restrictive.
Referring to several examples, the present invention is described in detail.
Component A is N-acyl amino acid surfactant, and B component is nanometer silver, and component C is nanometer Margarita powder, and component D is nano-tourmaline, and component E is moisturizing composition, and component F is moisture-keeping composition, and component G is a nanometer pollen.
A1 sodium lauroyl glutamate aginomoto LS-11
A2 cocoyl L-Ala triethanolamine salt aginomoto ACT-12
A3 cocoyl glycine potassium aginomoto GCK-12K
B1 nanometer silver particle diameter 5nm Shanxi big science and technology JDTKS-001
B2 nanometer silver particle diameter 15nm space auspicious (Shanghai) Chemical Co., Ltd.
C nano pearl powder Zhuji City Bi Chunqing pearl company limited
D nano-tourmaline Tianjin swan goose tienshanite industry Nanosolutions GmbH particle diameter 75nm
The weight ratio of E1 hyaluronic acid-collagen protein hyaluronic acid and collagen protein is 1:50, and the molecular-weight average of hyaluronic acid is about Ze Bang bio tech ltd, 2000000Da hyaluronic acid Xi'an, Rayleigh bio tech ltd, collagen protein Xi'an
The weight ratio of E2 hyaluronic acid-collagen protein hyaluronic acid and collagen protein is 1:75, and the molecular-weight average of hyaluronic acid is about Ze Bang bio tech ltd, 800000Da hyaluronic acid Xi'an, Rayleigh bio tech ltd, collagen protein Xi'an
The weight ratio of E3 hyaluronic acid-collagen protein hyaluronic acid and collagen protein is 1:100, and the molecular-weight average of hyaluronic acid is about Ze Bang bio tech ltd, 50000Da hyaluronic acid Xi'an, Rayleigh bio tech ltd, collagen protein Xi'an
Rayleigh bio tech ltd, E4 collagen protein Xi'an
The kinematic viscosity of F1 Aloe oil-glycerine Aloe oil is 0.54mm2The weight ratio of/s, Aloe oil and glycerine is the 1:40 Aloe oil Guangzhou Chinese one hundred this daily use chemicals developments in science and technology company limited, natural fats and oils Chemical Co., Ltd. of glycerine Malaysia
The kinematic viscosity of F2 Aloe oil-glycerine Aloe oil is 1.42mm2The weight ratio of/s, Aloe oil and glycerine is that 1:70 Aloe oil Guangzhou is refined in makeup company limited, natural fats and oils Chemical Co., Ltd. of glycerine Malaysia
The kinematic viscosity of F3 Aloe oil-glycerine Aloe oil is 2.33mm2The weight ratio of/s, Aloe oil and glycerine is 1:100 Aloe oil Guangzhou Pin Ding Chemical Industry Science Co., Ltd, natural fats and oils Chemical Co., Ltd. of glycerine Malaysia
Natural fats and oils Chemical Co., Ltd. of F4 glycerine Malaysia
Lan Mei bio tech ltd, G1 nanometer rose powder Anyang
G2 nanometer of chrysanthemum powder Bozhou Ding Long pharmaceutcal corporation, Ltd
G3 nanometer of lily bulb powder Bozhou City good fortune note Chinese medicinal materials station
Other: sodium-chlor Langfang Peng Cai Fine Chemical Co., Ltd, pigment Dongguan City Cai Hui Chemical Co., Ltd., citric acid Langfang Peng Cai Fine Chemical Co., Ltd