CN105663001B - Auxotype women private portion conditioning liquid and preparation method thereof - Google Patents
Auxotype women private portion conditioning liquid and preparation method thereof Download PDFInfo
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- CN105663001B CN105663001B CN201610100802.9A CN201610100802A CN105663001B CN 105663001 B CN105663001 B CN 105663001B CN 201610100802 A CN201610100802 A CN 201610100802A CN 105663001 B CN105663001 B CN 105663001B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/26—Aluminium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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Abstract
Environmentally protective auxotype women private portion conditioning liquid; in parts by weight, 35-55 parts of N- acyl amino acid surfactant, 0.01-0.1 parts of nano silver, 0.1-0.5 parts of Nano pearl powder, 0.02-0.1 parts of nano-tourmaline, 1-3 parts of moisturizing composition, 10-30 parts of moisture-keeping composition, 1-2 parts of nanometer pollen, 100 parts of water are included at least；Amino acid in the N- acyl amino acid surfactant is selected from one of neutral amino acid or acidic amino acid, and the moisturizing composition includes hyaluronic acid, collagen, and the moisture-keeping composition includes aloe, glycerol.
Description
Technical field
The present invention relates to feminine care products fields, and in particular to a kind of auxotype women private portion's conditioning liquid and preparation side
Method.
Background technique
With the development of the times, people's lives rhythm becomes to be getting faster, and the social role that women undertakes is more and more,
Pressure is also increasing.Women self health consciousness constantly enhances, and personal care articles also continue to develop therewith.For the shield in private portion
The prevention and treatment of reason and disease are then parts critically important in health maintenance, and private portion's nursing materials is preferably to select.
The sterilizing function of the portion of women private at present articles is mainly realized by addition chemical substance, is killed using chemical method
Bacterium.Such as select bromination dodecyl dimethyl hexadecyldimethyl benzyl ammonium or 2,4,4 '-three chloro- 2 '-dihydroxy diphenyl ethers etc..These chemical sterilizations
Agent is bigger to the skin irritatin of women privates, not safe enough for nursing, and is not solved yet in terms of mild and comprehensive performance
Certainly.Its chemical substance added can bring some side effects, and bacterium can also be made to generate drug resistance.After long-time service, it is easily destroyed
Female pathology environment causes bacterium colony disorder, is easy to produce lesion.
Nano silver is the novel antibacterial product developed based on nanotechnology, compares Ag+With more stable physics
Chemical characteristic has very excellent characteristic in terms of electricity, optics and catalysis.Environmental protection is one of China's fundamental state policy,
One kind that nano silver belongs to physical sterilization method is compared with chemical bactericide to be had the special feature that, national policy guiding is met.In addition,
Nano silver will not generate other waste water and exhaust gas during the preparation process, will not damage to environment.Due to quantum effect, small ruler
Very little effect and huge specific surface area, the antibacterial effect that nano silver has traditional inorganic antiseptic incomparable, have silver
Potent disinfecting and sterilizing functions have the breakthrough of matter, safety is higher, and effect continues more permanent.Nano silver is that non-antibiotics kill
Microbial inoculum generates drug resistance to silver currently without any bacterium.
Surfactant of the amino acid surfactant relative to traditional sulfur-bearing, has the special feature that, meets China's policy
Guiding, has a vast market foreground.Amino acid surfactant is to the highly-safe of environmental and biological materials, to skin and hair
There is compatibility.The characteristic of N- acyl amino acid surfactant is different from fatty acid soaps, because such surfactant exists
There is hydrophilic amino acid group, sodium salt has better water-soluble, surface-active and micella than corresponding sodium soap
Ability of aggregation.Since the molecular structure of N- acyl amino acid surfactant is the natural amphiphatic molecule structure of simulation, and with can
Fertile absorber is raw material, therefore has good biological degradability.The substance can be decomposed by the intracorporal enzyme of people fatty acid and
Amino acid.N- acylamino acid has anti-microbial property simultaneously, especially has antibacterial action to gram-positive bacteria and part der Pilz.
Amino acid surfactant is not only to the highly-safe of environmental and biological materials, and, irritation is small, rises to hair and skin action temperature
Bubble and emulsifiability are good, and dirt-removing power is strong, and biodegradability is good, also have outstanding bacteriostasis property and bactericidal property.Not only
Environment amenable requirement is met, the requirement that Product Safety and mild is continuously improved in people is also met.With life
Production technology constantly improve and improving, and production-scale expansion and the reduction of cost will promote it to be widely used in its people
The every field of economic development.
Skin surface has one layer of cuticula, and moisturizing and moisturizing materials with higher molecular weight are difficult directly to penetrate into thin
Born of the same parents.In addition, nursing materials and skin contact time are shorter, these factors all reduce intake of the skin to nutriment, make to protect
It manages ineffective.
Summary of the invention
In order to solve prior art problem, the present invention provides a kind of auxotype women private portion conditioning liquid, in parts by weight, until
Less include following components:
Amino acid in the N- acyl amino acid surfactant in neutral amino acid or acidic amino acid one
Kind, the moisturizing composition includes hyaluronic acid, collagen, and the moisture-keeping composition includes aloe, glycerol.
As a preferred technical solution of the present invention, the structural formula of the N- acylamino acid are as follows:
R1For the alkyl containing 3-29 carbon atom, R2For hydrogen atom or the substituent group containing 1-20 carbon atom, X1For hydrogen original
One of son, alkali metal, alkaline-earth metal, ammonium, alkanolamine residue, N- alkyltaurate.
As a preferred technical solution of the present invention, amino acid in the N- acylamino acid be selected from phenylalanine,
Methionine, threonine, isoleucine, leucine, valine, alanine, tyrosine, norvaline, aspartic acid, silk ammonia
Acid, homoserine, cysteine, homocysteine, selenocystein, homocystine, cystine, glutamic acid, glycine, Gao Yi
At least one of leucine, nor-leucine.
As a preferred technical solution of the present invention, the acyl group in the N- acylamino acid is selected from lauroyl, coconut palm
Oleoyl, myristoyl, palmityl, pearly-lustre fatty acyl group, stearyl, isostearoyl base, peanut acyl group, behenyl acyl group,
Haze tallow acyl group, wax acyl group, melissa acyl group, fatty acid distribution of coconut oil acyl group, palm oil fatty acid acyl group, palm kernel fatty acid acyl group,
At least one of tallow fatty acids acyl group and hardening tallow fatty acids acyl group.
As a preferred technical solution of the present invention, the particle size of the nano silver is 1-20nm, and the nanometer is precious
The particle size of pearl powder is 200-800nm, and the particle size of the nano-tourmaline is 50-100nm.
As a preferred technical solution of the present invention, the average molecular weight of the hyaluronic acid is 50000-
2200000Da。
As a preferred technical solution of the present invention, the weight ratio of the hyaluronic acid and collagen is 1:(50-
100)。
As a preferred technical solution of the present invention, the weight ratio of the aloe and glycerol is 1:(40-100).
As a preferred technical solution of the present invention, the nanometer pollen is grinding to obtain by the flower of plant, the plant
Object is selected from least one of rosaceae, composite family, Liliaceae.
A kind of preparation method of auxotype women private portion as described above conditioning liquid, comprises the following steps:
(1) N- acyl amino acid surfactant, aloe, glycerol, water are added in container A, heating stirring is uniform；
(2) nano-tourmaline, nano silver, Nano pearl powder, nanometer pollen, water are added in container B, stirring is equal at room temperature
It is even；
(3) mixture in container B pours into container A, sequentially adds hyaluronic acid, collagen at room temperature, stirring
Filling after uniformly, packaging.
Above and other features, aspects and advantages of the invention are more readily understood with reference to following detailed description.
Specific embodiment
With reference to preferred embodiment of the invention below detailed description and including embodiment this public affairs can be more easily to understand
Open content.A large amount of term is referred in following description and claims, these terms are defined as following contain
Justice.
" optionally " or " optionally " refer to that subsequently described event or item may or may not occur, and the description
The situation that the situation and event occurred including event does not occur.
Approximate term in specification and claims is used to modify quantity, and it is specific to indicate that the present invention is not limited to this
Quantity further includes the acceptable modified part without will lead to the change of dependency basis this function close with the quantity.Phase
It answers, modifies a numerical value with " about ", " about " etc., mean that the present invention is not limited to the exact numericals.In some examples, approximate
Term likely corresponds to the precision of the equipment of measurement numerical value.In present specification and claims, range limits can be with
Combination and/or exchange, these ranges if not stated otherwise include all subranges contained therebetween.
As used herein term " by ... preparation " it is synonymous with "comprising".Term "comprising" used herein, " comprising ",
" having ", " containing " or its any other deformation, it is intended that cover non-exclusionism includes.For example, the combination comprising listed elements
Object, step, method, product or device are not necessarily limited to those elements, but may include not expressly listed other elements or
Such composition, step, method, product or the intrinsic element of device.
Conjunction " Consists of " excludes any element that do not point out, step or component.If in claim, this
Phrase will make claim closed, so that it is not included the material in addition to the material of those descriptions, but relative normal
Except rule impurity.When being rather than immediately following after theme in the clause that phrase " Consists of " appears in claim main body,
It is only limited to element described in the clause；Other elements are not excluded except the claim as a whole.
Equivalent, concentration or other values or parameter are preferred with range, preferred scope or a series of upper limit preferred values and lower limit
When being worth the Range Representation limited, this should be understood as specifically disclosing by under any range limit or preferred value and any range
Any pairing of limit or preferred value is formed by all ranges, regardless of whether the range separately discloses.For example, when disclosing
When range " 1 to 5 ", described range should be interpreted as including range " 1 to 4 ", " 1 to 3 ", " 1-2 ", " 1-2 and 4-5 ", " 1-
3 and 5 " etc..When numberical range is described herein, unless otherwise stated, otherwise the range be intended to include its end value and
All integers and score within the scope of this.
In addition, indefinite article "an" before element of the present invention or component and "one" quantitative requirement to element or component
(i.e. frequency of occurrence) unrestriction.Therefore "one" or "an" should be read as including one or at least one, and odd number
The element or component of form also include plural form, unless the obvious purport of the quantity refers to singular.
Average molecular weight specified in the present invention is the molecular weight calculated by the inherent viscosity of sample.In the present invention, use
Inherent viscosity is found out by kinematic viscosity, the method which is scaled molecular weight, to find out average molecular weight.More specifically
Say that in the method, the determination of ubbelohde viscometer kinematic viscosity that use illustrates below finds out characteristic by the value of the kinematic viscosity in ground
The inherent viscosity is scaled average molecular weight by viscosity.
Generally, in order to find out the inherent viscosity of sample, firstly, multiple sample solutions are prepared, by the examination of Ubbelohde viscometer
Material solution flow down number of seconds and solvent flow down number of seconds, be based on following formula (1) and formula (2), calculating specific viscosity and reduced viscosity.
Formula (1)
Formula (2)
Secondly, using obtained reduced viscosity as the longitudinal axis, the sample concentration with dried object conversion is cross for each sample solution
Axis marks and draws production calibration curve and obtains the inherent viscosity of sample by the way that above-mentioned sample concentration is extrapolated to 0.Sample is hyalomitome
When sour, according to following formula (3), average molecular weight M can be found out by the inherent viscosity of sample.
Formula (3)
Inherent viscosity (dL/g)=k ' Mα
(in above-mentioned formula (3), k '=0.036, α=0.78).
Secondly, the measuring method of the kinematic viscosity of index when finding out above-mentioned average molecular weight for becoming is illustrated.
Above-mentioned kinematic viscosity is able to use Ubbelohde viscometer and is measured.At this point, selecting to flow down number of seconds as 200-1000 seconds
Coefficient Ubbelohde viscometer.In addition, measurement carries out in 30 DEG C of thermostatic water bath so that temperature-resistantization.
It, can by the product of the coefficient for flowing down number of seconds and Ubbelohde viscometer of the aforesaid liquid using determination of ubbelohde viscometer
Find out kinematic viscosity (unit: mm2/s)。
A kind of auxotype women private portion conditioning liquid includes at least following components in parts by weight:
Amino acid in the N- acyl amino acid surfactant in neutral amino acid or acidic amino acid one
Kind, the moisturizing composition includes hyaluronic acid, collagen, and the moisture-keeping composition includes aloe, glycerol.
As a preferred technical solution of the present invention, the weight ratio of the moisturizing composition and moisture-keeping composition is 1:
10。
N- acyl amino acid surfactant
Compared with fatty acid surfactant, N- acylamino acid be by inserted between alkyl and carboxyl 1-
CONHCHR- (side chain that R is amino acid) base is constituted.Its property is different with the side chain of amino acid and changes, when insertion ammonia
When base, the acid of carboxylic acid increases, and fatty acid salt aqueous solution will be become neutral from alkalescent.The solubility of its alkali salt increases
Height also has good foam performance in hard water.When in the treatment of skin, it can make skin that there is lubrication sense.Amine key tool
The property of strong hydrogen bonding between visible component, it is intermolecular when combining in aqueous solution, it will affect coherent condition.
N- acylamino acid has physiological activity, such as N- Hamposyl L salt has antibiosis to the lactic acid bacteria for leading to saprodontia
Activity, N- lauroyl valine have Antibiotic activity to rice blast pathogen, and N- oleic acid acyl glutamate is to interference amino acid fermentation
Bacteriophage has antibiosis.
As a kind of technical solution of the invention, N- acyl amino acid surfactant is selected from N- acyl group peptide salt.System
The raw material of standby N- acyl group peptide salt can be collagen.Collagen is the fibrous solids for constituting animal skeleton, skin, tendon etc.
Protein, without antibiosis, use is safe.Collagen, through appropriate hydrolysis, is formed in alkaline medium and in the presence of enzyme through gelatin
Molecular weight is the peptide of 400-2000, is then acylated with chlorination coco-nut oil fatty acid, then neutralized with potassium hydroxide to obtain the final product
N- acyl group peptide salt.
As a kind of technical solution of the invention, N- acyl amino acid surfactant is selected from N- acyl sarcosinates.
As a kind of technical solution of the invention, N- acyl amino acid surfactant is selected from N- acyl-N-methyl-β-ammonia
Base propionate.
As a kind of technical solution of the invention, N- acyl amino acid surfactant is selected from N- acyl glutamate.N-
There are 2 carboxyls in acyl glutamic acid molecule, due to degree of neutralization difference, property has very big difference.When a carboxyl is by
And when, another carboxyl exists in aqueous solution with free state, keeps aqueous solution weakly acidic.
As a kind of technical solution of the invention, N- acyl amino acid surfactant is selected from the lipid of N- acylamino acid
And amide.
As a kind of technical solution of the invention, N- acyl amino acid surfactant is selected from higher alcohol amino-acid ester.Example
The ester generated such as neutral alanine and higher alcohol is cationic surfactant, soluble easily in water, have good surface-active and
Foaming capacity.
As a preferred technical solution of the present invention, the structural formula of the N- acylamino acid are as follows:
R1For the alkyl containing 3-29 carbon atom, R2For hydrogen atom or the substituent group containing 1-20 carbon atom, X1For hydrogen original
One of son, alkali metal, alkaline-earth metal, ammonium, alkanolamine residue, N- alkyltaurate.
R1It can be saturated chain alkyl, including but not limited to propyl, isopropyl, normal-butyl, isobutyl group, sec-butyl, tertiary fourth
Base, n-pentyl, 1- methyl butyl, 2- methyl butyl, 3- methyl butyl, 1- ethyl propyl, 1,1- dimethyl propyl, 1,2- diformazan
Base propyl, 2,2- dimethyl propyl, n-hexyl, 1- methyl amyl, 2- methyl amyl, 3- methyl amyl, 4- methyl amyl, 1- second
Base butyl, 2- ethyl-butyl, 1,1- dimethylbutyl, 1,2- dimethylbutyl, 1,3- dimethylbutyl, 2,2- dimethyl butyrate
Base, 2,3- dimethylbutyl, 3,3- dimethylbutyl, 1,1,2- thmethylpropyl, 1,2,2- thmethylpropyl, n-heptyl, 1-
Methylhexyl, 2- methylhexyl, 3- methylhexyl, 4- methylhexyl, 5- methylhexyl, 1- ethylpentyl, 2- ethylpentyl, 3-
Ethylpentyl, 1,1- dimethyl amyl group, 1,2- dimethyl amyl group, 1,3- dimethyl amyl group, 1,4- dimethyl amyl group, 2,2- diformazan
Base amyl, 2,3- dimethyl amyl group, 2,4- dimethyl amyl group, 3,3- dimethyl amyl group, 3,4- dimethyl amyl group, 4,4- dimethyl
Amyl, 1,1,2- trimethyl butyl, 1,1,3- trimethyl butyl, 1,2,2- trimethyl butyl, 1,2,3- trimethyl butyl, 1,3,
3- trimethyl butyl, 2,2,3- trimethyl butyl, 2,3,3- trimethyl butyl, octyl, nonyl, decyl, undecyl, laurel
Base, tridecyl, myristyl, pentadecyl, palmityl, pearly-lustre aliphatic radical, stearyl, nonadecyl, peanut base, behenyl base,
Haze tallow base, cerul, nonacosyl.
R1It is also possible to saturated cyclic, including but not limited to cyclopenta, cyclohexyl, 2- methylcyclopentyl, 3- methyl ring
Amyl, suberyl, 2- methylcyclohexyl, 3- methylcyclohexyl, 4- methylcyclohexyl, 2- ethylcyclopentyl, 3- ethylcyclopentyl,
Cyclooctyl, 2- methylcycloheptyl, 3- methylcycloheptyl, 4- methylcycloheptyl, 2,2- Dimethylcyclohexyl, 2,3- dimethyleyelohexane
Base, 2,4- Dimethylcyclohexyl, 3,3- Dimethylcyclohexyl, 3,4- Dimethylcyclohexyl, 4,4- Dimethylcyclohexyl.
R1Be also possible to unsaturated alkyl, including but not limited to 2- acrylic, 1- acrylic, 1- cyclobutenyl, 2- cyclobutenyl,
3- cyclobutenyl, 1- methyl-1-propylene base, 1- methyl -2- acrylic, 2- methyl-1-propylene base, 2- methyl -2- acrylic, 1- penta
Alkenyl, 2- pentenyl, 3- pentenyl, 4- pentenyl, 1- methyl-1-cyclobutenyl, 1- methyl-2-butene base, 1- methyl-3- butylene
Base, 2-methyl-1-butene alkenyl, 2- methyl-2-butene base, 2- methyl -3- cyclobutenyl, 3-methyl-1-butene base, 3- methyl -2-
Cyclobutenyl, 3- methyl -3- cyclobutenyl, 1,2- dimethyl -1- acrylic, 1,1- dimethyl -2- acrylic, 1,2- dimethyl -2-
Acrylic, 1- hexenyl, 2- hexenyl, 3- hexenyl, 4- hexenyl, 5- hexenyl, 1- methyl-1-pentene alkenyl, 1- methyl -2-
Pentenyl, 1- methyl-3-pentenyl, 1- methyl -4- pentenyl, 2- methyl-1-pentene alkenyl, 2- methyl -2- pentenyl, 2- first
Base -3- pentenyl, 2- methyl -4- pentenyl, 3- methyl-1-pentene alkenyl, 3- methyl -2- pentenyl, 3- methyl-3-pentenyl,
3- methyl -4- pentenyl, 4-methyl-1-pentene base, 4- methyl -2- pentenyl, 4- methyl-3-pentenyl, 4- methyl -4- amylene
Base, 1- ethyl -1- cyclobutenyl, 1- ethyl -2- cyclobutenyl, 1- ethyl -3- cyclobutenyl, 2- ethyl -1- cyclobutenyl, 2- ethyl -2-
Cyclobutenyl, 2- ethyl -3- cyclobutenyl, 1,1- dimethyl -2- cyclobutenyl, 1,1- dimethyl -3- cyclobutenyl, 1,2- dimethyl -1-
Cyclobutenyl, 1,2- dimethyl -2- cyclobutenyl, 1,2- dimethyl -3- cyclobutenyl, 1,3- dimethyl -1- cyclobutenyl, 1,3- diformazan
Base -2- cyclobutenyl, 1,3- dimethyl -3- cyclobutenyl, 2,2- dimethyl -3- cyclobutenyl, 2,3- dimethyl -1- cyclobutenyl, 2,3-
Dimethyl-2- cyclobutenyl, 2,3- dimethyl-3- cyclobutenyl, 2- methyl-1-cyclopentenyl, 3- methyl-1-cyclopentenyl, 4- first
Base-1- cyclopentenyl, 5- methyl-1-cyclopentenyl, 2- methyl-2- cyclopentenyl, 3- methyl-2- cyclopentenyl, 4- methyl-2-
Cyclopentenyl, 5- methyl -2- cyclopentenyl, 2- methyl -3- cyclopentenyl, 3- methyl -3- cyclopentenyl, 4- methyl -3- ring penta
Alkenyl, 5- methyl -3- cyclopentenyl, 1- cyclohexenyl group, 2- cyclohexenyl group, 3- cyclohexenyl group, α-flax base, stearidonic
Base, two dodecahexaene bases, sub- oil base, is conjugated sub- oil base, γ-flax base, 20 carbon trialkenyls, peanut at eicosapentaenoic base
Apos, oil base, eicosylene base, 20 carbon trialkenyls, mustard base.
As a preferred technical solution of the present invention, wherein the acyl group in N- acylamino acid is selected from lauroyl, coconut palm
Oleoyl, myristoyl, palmityl, pearly-lustre fatty acyl group, stearyl, isostearoyl base, peanut acyl group, behenyl acyl group,
Haze tallow acyl group, wax acyl group, melissa acyl group, fatty acid distribution of coconut oil acyl group, palm oil fatty acid acyl group, palm kernel fatty acid acyl group,
At least one of tallow fatty acids acyl group and hardening tallow fatty acids acyl group.
R2Can be hydrogen atom, be also possible to hydrocarbyl substituent, including but not limited to methyl, ethyl, propyl, isopropyl,
Normal-butyl, isobutyl group, sec-butyl, tert-butyl, n-pentyl, 1- methyl butyl, 2- methyl butyl, 3- methyl butyl, 1- ethyl third
Base, 1,1- dimethyl propyl, 1,2- dimethyl propyl, 2,2- dimethyl propyl, n-hexyl, 1- methyl amyl, 2- methyl amyl,
3- methyl amyl, 4- methyl amyl, 1- ethyl-butyl, 2- ethyl-butyl, 1,1- dimethylbutyl, 1,2- dimethylbutyl, 1,
3- dimethylbutyl, 2,2- dimethylbutyl, 2,3- dimethylbutyl, 3,3- dimethylbutyl, 1,1,2- thmethylpropyl, 1,
2,2- thmethylpropyl, octyl, nonyl, decyl, undecyl, lauryl, tridecyl, myristyl, pentadecyl, palm
Base, pearly-lustre aliphatic radical, stearyl, nonadecyl, peanut base, behenyl base, haze tallow base, cerul, nonacosyl, α-flax base, ten
Eight carbon apos, two dodecahexaene bases, sub- oil base, are conjugated sub- oil base, γ-flax base, 20 carbon triolefins at eicosapentaenoic base
Base, arachidonic base, oil base, eicosylene base, 20 carbon trialkenyls, mustard base.
R2It is also possible to the substituent group containing elements such as aerobic, nitrogen, sulphur, including but not limited to methylene p-hydroxybenzene, second
Acidic group, amion acetic acid base, propionyloxy, propionamido-, methylmercaptoethyl, methylol, ethoxy, 1- hydroxyethyl, thiopurine methyltransferase, mercapto
Ethyl.
As a preferred technical solution of the present invention, amino acid in the N- acylamino acid be selected from phenylalanine,
Methionine, threonine, isoleucine, leucine, valine, alanine, tyrosine, norvaline, aspartic acid, silk ammonia
Acid, homoserine, cysteine, homocysteine, selenocystein, homocystine, cystine, glutamic acid, glycine, Gao Yi
At least one of leucine, nor-leucine.
X1It can be hydrogen atom, be also possible to alkali metal, such as: sodium, potassium.X1It is also possible to alkaline-earth metal, such as: magnesium,
Calcium.X1It is also possible to ammonium salt, is also possible to alkanolamine residue, wherein alkanolamine can be enumerated such as carbinolamine, dimethanolamine, three
Carbinolamine, ethanol amine, diethanol amine, triethanolamine, Propanolamine, dipropanolamine, tripropanol amine.X1It is also possible to N- alkyl ox sulphur
Hydrochlorate, alkyl can be methyl, ethyl, propyl, isopropyl, and salt can be ammonium salt, sodium salt, sylvite, magnesium salts, calcium salt, diethyl
Alcohol amine salt, triethanolamine salt.Above with respect to X1Enumerate by way of example only, it is not limited to cited substance.
Using water as 100 parts by weight, the content of the N- acyl amino acid surfactant is 35-55 parts by weight.
Nano silver
Since nano silver has great specific surface area, silver ion, the sterilization of nano silver can be dissociateed in aqueous solution
Principle is similar with silver ion, but the effective concentration of nano silver and silver ion is entirely different.The partial size of nano silver is smaller, permeability
Stronger, bactericidal property is stronger.The size of nano-Ag particles is smaller, can easily enter zymoprotein in pathogen, with thallus
Sulfydryl combines rapidly, and some enzymes as necessary group is made to lose vigor, make pathogenic bacteria not energy metabolism and it is dead, to reach
Sterilization, repair tissue, the effect for promoting wound healing.Nano silver in conjunction with DNA of pathogenic base and can form interconnection,
The hydrogen bond in purine and pyrimidine between adjacent nitrogen, bacterium DNA replication Disability are replaced, protein inactivation causes pathogenic bacteria to be lost
It is living.Nano silver can also be reacted with amino, the carboxyl in bacterium, have the function that kill bacterium or mould.Nano silver can kill
Dead staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, streptococcus pyogenes, enterococcus, chlamydia trachomatis, leaching
Coccus etc..
Nano silver can kill a variety of germs being harmful to the human body as new-type wide-spectrum bactericide in a short time, not generate
Any drug resistance.And permeability is strong, can be penetrated into from the pore of skin it is subcutaneous, to common bacteria, stubborn bacteria, resistance to
Medicine bacterium and fungus-caused infection have good bactericidal effect.Nano silver can also promote wound healing, improve wound week
The blood circulation of tissue is enclosed, tissue cell growth can be promoted, accelerating wound healing reduces the generation of scar.
The particle size of the nano silver is 1-20nm, preferably 1-10nm.
The preparation of nano silver can use physical-chemical process and chemical reduction method.Physical-chemical process is divided into light quantum reduction
Method, laser lift-off, high-pressure magnetic sputtering method, ultrasonic method；Chemical reduction method includes silver-amino coordination ion reduction method, electrochemical reduction
Method, reverse micelle method.
Light quantum reduction method is to prepare a kind of important method of nano silver, the basic principle is that producing solution by illumination
The free radical group of raw hydrated electron and reduced form, hydrated electron or free radical group can be with the silver ion in reducing solution, shapes
It at activation silver, activates silver and is continuously accumulated into larger particles, then with high molecular polymer or other medium stable particles, use the method
The reproducibility for preparing nano silver is preferable, and is to carry out at room temperature, also not by the interference for the impurity that may be introduced.Light quantum is also
The reduction process of former method is homogeneous reaction, and there is no the excessive problems of local concentration.Furthermore, it is possible to generate water with ultraviolet light
Change electronics or reduced form free radical group.
Laser lift-off preparation process is as follows, and silver foil is placed on to the bottom of glass container, and 10 milliliters of surfactants are added
The solution of (such as lauryl sodium sulfate or dodecyl sodium sulfate), solvent can be water, butanol, hexane etc..It is focused with laser
The second harmonic that lens generation wavelength is 532nm irradiates silver foil, pulse width 10ns, repetition rate 10Hz.Pass through change
The distance between lens and silver foil adjust the spot size of laser beam to 1-3mm.After laser irradiation silver foil, plasma can be generated
Body makes silver foil be converted into nano-scale particle.Then it by centrifugation, is extracted with decantation.
High-pressure magnetic sputtering method needs inert gas (such as helium, argon, krypton) atmosphere, and gas pressure intensity maintains 3mtorr -1torr
Between, sputtering source can use DC power supply, axial length about 200mm, planar diameter about 50mm, peak power output moon 1kw.Sputtering
Voltage can be about 350V.When forming stable plasma, the nano-Ag particles sputtered can be cooled down from liquid nitrogen instrument
Copper substrate on collect and obtain.The distance of substrate and sample about 5.5cm.
Ultrasonic method is to contain surfactant (such as lauryl sodium sulfate, dodecyl using supersonic generator ultrasound
Benzene sulfonic acid sodium salt, polyvinylpyrrolidone, polyoxyethylene sorbitan monolaurate, polyethylene glycol mono stearate etc.) Ag+
Solution, Ag+It is reduced to obtain nanoscale Argent grain.
Silver-amino coordination ion reduction method is to silver nitrate aqueous solution enriching ammonium hydroxide, and dripping hydrogen peroxide can produce nano silver
Grain reacts as follows:
2Ag(NH3)2 ++H2O2+2OH-=2Ag+O2+4NH3+2H2O
Reaction carries out at low temperature, crystal grain will not occur because of high temperature and grow up, Argent grain system easy to control in size, product granularity point
Cloth is relatively narrow, also than more uniform.Another method is that stabilizer, such as polyvinylpyrrolidine are added into silver-amino coordination ion solution
Ketone, alkyl hydrosulfide, oleic acid and palmitinic acid etc. are nano silver with ascorbic acid or hydrazine hydrate or sodium borohydride reduction silver-amino coordination ion
Particle.Finally manufactured nano-Ag particles are immersed in passivator again, such as oleic acid, then oleic acid is filtered out, vacuum is dry
It is dry, obtain nano-Ag particles.The nano-Ag particles stability that this preparation method obtains is good, good dispersion.
Electrochemical reducing is to prepare nano metal using electrode reaction, the yield height of the method, easily separated, reaction process
Without metal hydride or boron impurity, particle size can be controlled by changing current density, which can produce the silver of 2-7nm
Grain.Metal anode is dissolved in aprotic solvent, the nano-Ag particles produced are pure.
Reverse micelle method is to prepare nano silver with colloid chemistry reduction silver ion.Reverse micelle refers to that surfactant has been dissolved in
In solvent, when concentration is more than critical micelle concentration, hydrophilic radical is formed inwardly, the particle of hydrophobic grouping outwardly.Reverse micelle
Kernel can solubilized hydrone form water core, silver ion is restored in water core and forms nanoparticle.Such as: in reverse micelle, use
Quercetin restores silver nitrate, can be made into the Argent grain of 1-1.5nm.It can also be in α-Al2O3Upper loading nano silvery particle, not
Rust steel utensil on inject silver ion after restore, active carbon nanoparticles area load nano silver, on various fabrics as nylon-11,
Loading nano silvery particle on nylon -66, and on polypropylene non-woven fabric, loading nano silvery particle on pure cotton cloth fabric.
Using water as 100 parts by weight, the content of the nano silver is 0.01-0.1 parts by weight.
Nano pearl powder
Since the dawn of human civilization, pearl signifies always rich, happy, happy and noble.Feudal society influential officials represent ground with pearl
Position, power, money and honorable identity, the common people are with pearl symbol happiness, safety and luckiness." name doctor is other for medical book when three states
Record ", " book on Chinese herbal medicine through collecting " in beam generation, " Haiyao Bencao, Oversea Materia Medica " of the Tang Dynasty, " Kaibao Bencao " of Song Dynasty, the Compendium of Material Medica of the Ming Dynasty, the Qing Dynasty
The medical ancient books such as Leigon's Nature of Drugs in Songs, all have specific record to the curative effect of pearl.The Pharmacopoeia of the People's Republic of China, " in
Medicine voluminous dictionary " indicate, pearl has arresting convulsion of calming the nerves, and improving eyesight disappears screen, solves taking poison and growing muscle due.For insomnia of palpitating with fear, infantile convulsion epilepsy, mesh is raw
Cloudiness, sore are not held back.
The inorganic constituents mass fraction of pearl accounts for 91% or more, and main body is aragonite and calcite, separately there is a small amount of magnesite,
It secondly is silica, calcium phosphate, Al2O3And Fe2O3Deng.The main body of pearl organic principle be Chitosan-alginate microcapsules (also referred to as keratoprotein or
Gu albumen) and various pigments.Organic matter in pearl contains L-aminobutanedioic acid, threonine, serine, glutamic acid, glycine, the third ammonia
Acid, cystine, valine, methionine, isoleucine, leucine, tyrosine, phenylalanine, histidine, arginine, proline
Deng 17 kinds of amino acid.In addition, also containing 30 various trace elements, taurine, vitamin abundant, peptides.
Pearl powder can be improved the activity of human skin superoxide dismutase (SOD), inhibit the synthesis of melanin, keep
Whitening skin.Further, since SOD has the function of removing free radical, skin aging, corrugation can be prevented.After being absorbed by the body, lead to
Participation organism metabolism is crossed, the whole conditioning and maintenance of skin are reached.It can promote neonatal cell to synthesize, and constantly add to skin
Surface layer makes skin smooth, exquisiteness, flexible.In addition, pearl powder is all natural ingredients, by participating in the metabolism of cell DNA, energy
Promote wound healing.The powder of Nano pearl powder is finer and smoother invisible, while its good absorption effect, improves the utilization of effective component
Rate.
The preparation method of Nano pearl powder can be enumerated as example: pearl being cleaned up, is dried.Then traditional Chinese medicine powder is used
Broken machine is by crushing pearl at corase meal, and the partial size of corase meal is between 80-1000 μm.By thick pearl powder airslide disintegrating mill powder
It is broken, oyster pearl powder is obtained, partial size is between 0.5-10 μm.In deionized water by oyster pearl powder ultrasonic disperse, high speed shear is used
Machine crushes.Nano grade is crushed to using nano grinder after drying.
As a preferred technical solution of the present invention, the particle size of the Nano pearl powder is 200-800nm.
Using water as 100 parts by weight, the content of the Nano pearl powder is 0.1-0.5 parts by weight.
Nano-tourmaline
Tourmaline is also referred to as tourmaline, be it is a kind of containing boron, aluminium, sodium, iron, lithium silicate mineral.Its chemical structure can
To be expressed as XY3Z6(T6O18)(BO3)3V3W can have differences according to the different chemical formulas in the place of production and mining area, and wherein X is generally Na
Or Ca K or vacancy.Y location is usually such as Li+、Mg2+、Fe2+、Mn2+、Al3+、Cr3+、V3+、Fe3+、Ti4+Deng
Multivalent state cation.Z location is mainly Tricationic, such as Al3+、Fe3+、Cr3+、V3+Deng being also possible to bivalent cation such as
Mg2+、Fe2+Deng.T location is usually Si, but is also likely to be Al or B according to the difference in the place of production.When these do not know element position
When by element substitutions such as Cr, V, Ti, Fe, Cu, tourmaline takes on a variety of different colors.
Tourmaline has [Si6O18] tripartite's ring structure is answered, belong to trigonal system.Tourmaline has piezoelectricity and pyroelectricity,
In the case that temperature and pressure changes, 1 × 10 can be generated between the lattice of tourmaline6The potential difference of eV, this electrostatic field energy
Enough make air ionization, that is hit is electronically attached to similar hydrone and oxygen molecule, them is made to be converted into negative aeroion.It receives
The other tourmaline specific surface area of meter level is very big, can generate a large amount of negative oxygen ions, also more preferable to the permeability of cell, generation
Negative oxygen ion can remove the intracorporal free radical of people, can delay senescence.Another advantage of tourmaline is can to give off wave
The wave frequency commensurate in scope that a length of 4-14 μm of electromagnetic wave and human body radiation goes out.Wave frequency will produce when matching
Raw resonance, can make one intracorporal water molecule activation, can make the nutritional ingredient of other high molecular weight can when acting on skin surface
To enter cell interior.
As a preferred technical solution of the present invention, the particle size of the nano-tourmaline is 50-100nm.
The preparation method of nano-tourmaline can use mechanochemical reaction, be divided into dry and wet.The particle diameter distribution of dry process
Width, unevenly, energy consumption are high, and the particle diameter distribution of wet process preparation is uniform, is easy to control, but needs by dry, decentralized processing.It can
Tourmaline fission is crushed to 1 μm with airflow milling, then with wet grinding, liquid phase medium uses deionized water, n-butanol, second
Alcohol obtains slurry, and abrasive media (zirconia ball that such as partial size is 1-3mm) is added and grinds certain time afterwards, is dried later
And decentralized processing.Milling time about 2h, the quality of solid and the volume ratio about 1:1 of liquid in slurry, can make to starch when solid is more
Body viscosity increases, and causes grinding machine to can not be successfully grinding, the partial size that tourmaline is obtained when solid is less is larger.The selection of liquid phase medium
Also it will affect particle size, tourmaline belongs to polar particulate, preferably polarizable medium.The viscosity of sample when using water as liquid phase medium
Larger, mobility is poor.Using n-butanol, ethyl alcohol as the viscosity of the sample of liquid phase medium low, good fluidity.
Using water as 100 parts by weight, the content of the nano-tourmaline is 0.02-0.1 parts by weight.
Moisturizing composition
As a preferred technical solution of the present invention, the moisturizing composition is made of hyaluronic acid and collagen.
The average molecular weight of hyaluronic acid be 500,000-200 ten thousand, be largely be present in biology it is intracorporal it is numerous tissue (such as
Subcutaneous tissue, eyeball, joint) polysaccharose substance.Its physiological function be moisture can be made to enter space between cells, and with protein knot
It closes and forms protein gel, cell is sticked together, the cell metabolism effect brought into normal play is played and keeps cell moisture, protection
Cell is accelerated to restore skin histology, improves Wound healing power of regeneration not by the infringement of pathogen, reduces scar, and enhancing is immune
The effects of power.In the present invention, hyaluronic acid refers to forms with 1 or more the disaccharides by glucuronic acid and N-acetyl-glucosamine
Constitutional repeating unit polysaccharide.It is also possible to hyaluronate, hyaluronate is not particularly limited, preferably pharmaceutically
Permissible salt, for example, sodium salt, sylvite, calcium salt, zinc salt, magnesium salts, ammonium salt etc. can be enumerated.
As long as the substance that hyaluronic acid this field generally uses used in the present invention, any substance, can be
The substance extracted from the natural goods such as animal, such as cockscomb, umbilical cord, skin, joint fluid bio-tissue etc., or the micro- life of culture
The chemical syntheses such as the fermentation method of substance obtained by object or zooblast, such as the bacterium that has used streptococcus etc. or enzymatic synthesis
Substance etc. can be used.
Collagen is the main component of skin corium, related with the elasticity of skin is maintained, but since the age increases, skin
Collagen amount is reduced, and the elasticity of skin is impaired, can promote formation or the skin aging of wrinkle.In addition, due to drying, cuticula
Then become shallow wrinkle when the removing of cuticula is slow with epidermis plumpness.The collagen that the present invention uses does not limit especially
It is fixed, use commercially available substance in the form of collagen.The object from ox-hide, pigskin, fish-skin, fish scale, cock skin etc. can be enumerated
Matter.There is no particular limitation for the molecular weight of collagen, it is contemplated that the problem of solubility and skin absorb, then average molecular weight is
3000-100000Da。
Hyaluronic acid and collagen can mutually promote in the absorption of skin surface, the inventors discovered that working as hyaluronic acid
Weight ratio with collagen is 1:(50-100) when, stimulation of the collagen to skin can be eliminated, is not in peculiar smell, heavy
It forms sediment and assembles, no allergic phenomena occurs.And collagen improve permeability of cell membranes, can make the nutrition of more hyaluronic acids at
Divide and is absorbed by the skin.
As a preferred technical solution of the present invention, the weight ratio of the hyaluronic acid and collagen is 1:(50-
100)。
As a preferred technical solution of the present invention, the average molecular weight of the hyaluronic acid is 50000-
2200000Da。
Using water as 100 parts by weight, the content of the moisturizing composition is 1-3 parts by weight.
Moisture-keeping composition
The use of present invention cooperation moisture-keeping composition, which is able to suppress, sticks thoughts and feelings that is greasy, astringent, and moistening with dense sense and water,
With excellent use feeling.The moisturizer can be sucrose, D-sorbite, glycerol, 1,3 butylene glycol, propylene glycol, dipropyl two
The sucroses such as alcohol or polyalcohols, 2-100 moles of polyalcohol parent nucleus and propylene oxide in molecule with 3 or more hydroxyls and
Polyethers based compound made of 50 moles of ethylene oxide or less addition polymerizations, ethyl glucuronide alcohol polyethers -10, chondroitin sulfate,
Hyaluronic acid, mucoitin sulfate, Carlow peaceful acid, Atelocollagen albumen, cholesterol -12- hydroxy stearic acid ester, bile acid list
Salt, 2-pyrrolidone-5-carboxylic acid's mono-salt, short chain soluble collagen, Rosa roxburghii Tratt extracting solution, Europe alpine yarrow extract, propylene glycol, dipropylene glycol,
1,3-BDO, 1,4-butanediol, diethylene glycol, triethylene glycol, its above molecular weight the glycols such as polyethylene glycol, glycerol,
The polyglycereol class of diglycerol, its above molecular weight, the sugar such as D-sorbite, mannitol, maltitol, xylitol, antierythrite
Alcohol, the carbohydrates such as fructose, glucose, galactolipin, maltose, lactose, trehalose, polypropylene glycol/ethylene glycol copolymer or secondly
Methyl ether etc..
As a preferred technical solution of the present invention, the moisture-keeping composition is made of glycerol and aloe.
Glycerol is the most common moisturizer in this field, but haves the shortcomings that moisture-retaining capacity is on the weak side.
The main component of aloe is aloe polysaccharide, protein, amino acid etc..Aloe is C12-C14Based on fatty acid
Crude vegetal can be widely used for the fields such as food, cosmetics, medicine, chemical industry comprising 169 kinds of intrinsic beneficiating ingredients of aloe,
There are the irreplaceable health care of other greases and beautification function.Wherein the saturated fatty acid in aloe ingredient accounts for a quarter, includes
Capric acid, lauric acid, myristic acid, pentadecanoic acid, palmitinic acid, Heptadecanoic acide, stearic acid.Unsaturated fatty acid accounts for 3/4ths,
Including palmitoleic acid, hexadecadienoic acid, oleic acid, linoleic acid, linolenic acid.In addition also contain succinic acid, malic acid, lactic acid, right
The organic acids such as coumaric acid.Aloe is because containing carotenoid and aloe-emodin and its derivative, color is muddy in chartreuse
Liquid, main component are Mixed Fatty Glyceride, and oleic acid (cis-9-octadecenoic acid) accounts for chief component.Aloe is
The mixture of triglycerides etc., fusing point and freezing point are a temperature ranges, and generally between 40-50 DEG C, specific gravity is smaller than water, with
Molecular weight increases and reduces, and increases with degree of unsaturation and increases.The refraction index of aloe increases with the increase of molecular weight, with
Double bond increases and increases.Conjugated double bond exists, and has higher refraction index than similar unconjugated double bond compound.
Aloe is retained lignin containing natural colloidality substance, has strong osmoticum, nutrient can be helped to penetrate into flesh
Skin gleditsia sinensis has strength cleaning, antimicrbial power effect, is natural saponin, has anti-inflammatory, detumescence, inhibits bacterial growth, is antipruritic, only
Pain and other effects.With the direct cosmetic result such as moist moisturizing, whitening spot-removing, anti-aging, hypo-allergenic.It plays simultaneously and restrains skin table
Face pathogenic microorganisms and bacterium kill to the harmful acarid of human skin, prevent the breeding of superficial microbes, prevent dermopathic
Occur.It is suitble to Oily, balance inhibits sebum secretion, promotes wound healing.
Beta carotene contained in aloe can enhance radiation and chemotherapy to the curative effect of tumour, and reduce them to body
Poison pay effect, improve the immune function of host.The pre- preventing tumor of beta carotene and adjuvant therapy treatment effect with it is anti-oxidant
Property is closely related.Contain multiple conjugated double bonds in beta carotene, is a good antioxidant, therefore body can be improved
Function of detoxification is conducive to carcinogenic substance fast deactivation, also has inhibiting effect to the activation of precarcinogen, beta carotene can also be sudden
It goes out and free radical and prevents the generation of free radical that from capable of effectively inhibiting caused by free radical similar to the effect of hepatocuprein
Lipid peroxidation.
Aloe and glycerol are used in mixed way as moisturizer, can obtain more permanent moistening effect, cooperate moisturizing group
Close object together, replenishing water and preserving moisture effect is more preferable.
As a preferred technical solution of the present invention, the weight ratio of the aloe and glycerol is 1:(40-100).
As a preferred technical solution of the present invention, the kinematic viscosity of the aloe is 0.5-1.5mm2/s。
Using water as 100 parts by weight, the content of the moisture-keeping composition is 10-30 parts by weight.
Nanometer pollen
As a preferred technical solution of the present invention, the nanometer pollen is grinding to obtain by the flower of plant, the plant
Object is selected from least one of rosaceae, composite family, Liliaceae.
Breaking method can enumerate for example: the flower of plant being dried, is ground using LC6L-60L nanometers of horizontal sand mills
It crushes, that is, arrives.
As a preferred technical solution of the present invention, the nanometer pollen is grinding to obtain by the flower of plant, the plant
Object is selected from least one of rose, chrysanthemum, lily.
Rose is rosaceae rose, on the books in Compendium of Material Medica: " rose, fragrance is most dense, clearly without it is turbid,
With without violent, soft liver wake up stomach, have a respite and blood ", record in supplementary Amplifications of the Compendium of Materia Medica: " wandering arthritis is controlled in rose regulating and activating blood circulation, qi-regulating,
Dysentery with vomiting, acute mastitis, pyogenic infections is from the beginning of stomachache due to emotional depression and the hyperactive liver-qi attacking the stomach." studies have shown that containing volatile oil (essential oil), saponin(e, organic acid, more in rose
The ingredients such as first phenols include citronellol, geraniol, nerol, linalool, benzyl carbinol, eugenol, gold in volatile oil (essential oil)
Silk tree alcohol and its esters, sequiterpene and its derivative etc..Rose is a kind of cosmetics and skincare product that applicating history is long, has beauty
The beauty functions such as white, oil-control, convergence pore.The effect of its moisturizing and nourishing can make the skin of dry sensitivity restore water profit in time tender；
Convergence, antibacterial and the calmness effect of releiving of rose, can inhibit excessive fat secretion, keep skin exquisiteness pure and fresh, not bellding light；And
There is anti-aging beneficial to the nutriment of human health rich in multivitamin, polyphenol, polysaccharide, amino acid etc. in rose
Effect, long-time service can make skin moisten and rich in gloss.Meanwhile nanometer rose powder can also play covering, coloring, absorption,
The effect sprawled.
Chrysanthemum is composite family Dendranthema, and " Bencao Jingshu " is recorded: " chrysanthemum autocracy wind wood, therefore the key medicine to remove wind.Hardship can be let out
Heat, Gan Nengyi blood is sweet to detoxify, flat then simultaneous pungent, therefore also dissipating bind." " drugization justice " record: " camomile, extracting waste person, body is light,
Mildly bitter flavor, property gas peace, until clear product." for chrysanthemum containing volatile oil, ingredient is mainly borneol, camphor, chrysanthenone, also containing sweet-scented osmanthus
- 7 glycosides of careless element, cosmosiin, that is, apiolin -7-O- glycoside, acaciin, apiolin, apiolin -7-O- sandlwood
Glycoside, robinin -7-O- glycoside Quercetin -3-O- galactoside, luteolin -7-O- sandlwood glycoside, wood
Rhinoceros grass element -7-O- sandlwood glycoside, luteolin, beta-elemene, Thymol, heneicosane, tricosane, 26
Alkane and carbohydrate and amino acid.Chrysanthemum is in vitro to gram-positive bacterium (staphylococcus aureus and beta hemolysis hammer
Bacterium), Bacillus tuberculosis have certain inhibiting effect.Its flooding agent to certain common skin pathogenic fungus, also make by some inhibition
With.There are also antiviral (PB8 plants) and anti-conveyor screw to act in vitro.
Lily is Liliaceae lily, is recorded in " Japan hanako materia medica ": " feeling at ease, determines gallbladder, beneficial will supports the five internal organs.It controls insane
Heresy crow position, it is mad cry, palpitate with fear, kill disease due to noxious agents produced by various parasites Qi , Xie acute mastitis, carbuncle on the back and all sore swells, and the mad fortune of blood after managing property." lily lily containing Ming River
Glucoside A, D, 3,6 '-O-, two asafoetide acyl sucrose, 1-O- asafoetide acyl glycerol, the p- coumaric acyl glycerol of 1-O-, 26-O- β-D- glucopyra
Glycosyl-slave Ah sapogenin -3-O- α-L- rhamnopyranosyl-(1 → 2)-β-D- glucopyanoside, 26-O- β-D- pyrans Portugal
Grape glycosyl-slave Ah sapogenin -3-O- α-L- rhamnopyranosyl-(1 → 2)-O- [β-D- glucopyranosyl (1 → 4)]-β-D-
Glucopyanoside.
It is other
Auxotype women private portion conditioning liquid of the invention also can according to need the other additives of cooperation, for its type
And use level, it can be suitable for selecting in the range of not impairing the effect of the present invention.As other additives, example can be enumerated
Such as: fragrance, pigment, salt, pearling agent, colorant, medicament, thickener, ultraviolet absorbing agent, coagent, pH adjusting agent.
Using water as 100 parts by weight, the content of other materials is 1-5 parts by weight.
A kind of preparation method of auxotype women private portion as described above conditioning liquid, comprises the following steps:
(1) N- acyl amino acid surfactant, aloe, glycerol, water are added in container A, heating stirring is uniform；
(2) nano-tourmaline, nano silver, Nano pearl powder, nanometer pollen, water are added in container B, stirring is equal at room temperature
It is even；
(3) mixture in container B pours into container A, sequentially adds hyaluronic acid, collagen at room temperature, stirring
Filling after uniformly, packaging.
Hereinafter, the present invention is explained in more detail by embodiment, it should be appreciated that these embodiments are only
Illustrate and not restrictive.
Referring to several example the present invention is described in detail.
Component A is N- acyl amino acid surfactant, and component B is nano silver, and component C is Nano pearl powder, and component D is
Nano-tourmaline, component E are moisturizing composition, and component F is moisture-keeping composition, and component G is nanometer pollen.
A1 sodium lauroyl glutamate aginomoto LS-11
A2 cocoyl alanine triethanolamine salt aginomoto ACT-12
A3 cocoyl glycine potassium aginomoto GCK-12K
The big science and technology JDTKS-001 in the Shanxi B1 nano silver partial size 5nm
Auspicious (Shanghai) Chemical Co., Ltd. of B2 nano silver partial size 15nm space
C nano pearl powder Zhuji City Bi Chunqing pearl Co., Ltd
D nano-tourmaline Tianjin swan goose tienshanite industry Nanosolutions GmbH partial size 75nm
The weight ratio of E1 hyaluronic acid-collagen hyaluronic acid and collagen is 1:50, the average mark of hyaluronic acid
Son amount about 2000000Da hyaluronic acid Xi'an Ze Bang Biotechnology Co., Ltd, collagen Xi'an Rayleigh biotechnology are limited
Company
The weight ratio of E2 hyaluronic acid-collagen hyaluronic acid and collagen is 1:75, the average mark of hyaluronic acid
Son amount about 800000Da hyaluronic acid Xi'an Ze Bang Biotechnology Co., Ltd, the limited public affairs of collagen Xi'an Rayleigh biotechnology
Department
The weight ratio of E3 hyaluronic acid-collagen hyaluronic acid and collagen is 1:100, the average mark of hyaluronic acid
Son amount about 50000Da hyaluronic acid Xi'an Ze Bang Biotechnology Co., Ltd, the limited public affairs of collagen Xi'an Rayleigh biotechnology
Department
E4 collagen Xi'an Rayleigh Biotechnology Co., Ltd
F1 aloe-glycerol aloe kinematic viscosity is 0.54mm2The weight ratio of/s, aloe and glycerol is 1:40 reed
This daily use chemicals development in science and technology Co., Ltd of the luxuriant growth oil Guangzhou Chinese one hundred, natural oil Chemical Co., Ltd., glycerol Malaysia
F2 aloe-glycerol aloe kinematic viscosity is 1.42mm2The weight ratio of/s, aloe and glycerol is 1:70 reed
Luxuriant growth oil Guangzhou is refined to cosmetics Co., Ltd, natural oil Chemical Co., Ltd., glycerol Malaysia
F3 aloe-glycerol aloe kinematic viscosity is 2.33mm2The weight ratio of/s, aloe and glycerol is 1:100
Aloe Guangzhou Pin Ding Chemical Industry Science Co., Ltd, natural oil Chemical Co., Ltd., glycerol Malaysia
Natural oil Chemical Co., Ltd., F4 glycerol Malaysia
G1 nanometer rose powder Anyang Lan Mei Biotechnology Co., Ltd
G2 nanometers of chrysanthemum powder Bozhou Ding Long pharmaceutcal corporation, Ltds
G3 nanometers of lily root flour Bozhou City good fortune remember Chinese medicine station
It is other: sodium chloride Langfang Peng Cai Fine Chemical Co., Ltd, pigment Dongguan City Cai Hui Chemical Co., Ltd., citric acid
Langfang Peng Cai Fine Chemical Co., Ltd
Embodiment (unit: parts by weight)
Evaluation method
1. sterilization ability is tested.
Take Clinical isolation staphylococcus aureus, Escherichia coli, B-mode micrococcus scarlatinae, albicans strain
A little, it is inoculated in broth bouillon respectively, cultivates 18h at a temperature of 37 DEG C.(B-mode micrococcus scarlatinae broth bouillon
It is middle addition 20% calf serum) take 18h cultivate each bacterial strain nutrient broth culture, by nutrient broth dilution be used to test.
Sterilizing test tubes 11 are taken, nutrient broth fluid nutrient medium 1.6mL is added in the 1st pipe, remaining every pipe 1mL takes reality respectively
It applies a 1-6 and comparative example 1 is added in the first pipe, take 1mL to the 2nd to manage after mixing, successively dilute, the 10th pipe is sucked out 1mL and discards, the
Sample is not added as control in 11 pipes.Dilution bacterium solution 0.1mL is added in every pipe, cultivates at a temperature of 37 DEG C for 24 hours, and it is raw to take out observation bacterium
Long situation.Such as test tube muddiness, i.e. expression bacterial growth, sample is without bacteriostasis；If test tube is limpid, indicate bacterial growth by
Inhibit, by limpid broth tubes transferred species broth agar plates, for 24 hours, the Cmin of no bacterial growth is as sterilized dense for observation
Degree, is denoted as C, unit mg/mL.
Experimental result is shown: women private provided by the invention portion's articles are to being clinically separated staphylococcus aureus, large intestine bar
Bacterium, B-mode micrococcus scarlatinae, Candida albicans all have stronger bacteriostasis.It see the table below.
2. whitening function is tested.
85 volunteers are selected, with 5 volunteers for 1 group, are divided into 17 groups.1st group uses embodiment 1, and the 2nd group using real
Example 2 is applied, the 3rd group uses embodiment 3, and the 4th group uses embodiment 4, and the 5th group uses embodiment 5, and the 6th group uses embodiment the 6, the 7th
Group uses embodiment 7, and the 8th group uses embodiment 8, and the 9th group uses embodiment 9, and the 10th group uses embodiment 10, the 11st group of use
Embodiment 11, the 12nd group uses embodiment 12, and the 13rd group uses comparative example 2, and the 14th group uses comparative example 3, the 15th group of use pair
Ratio 4, the 16th group uses comparative example 5, and the 17th group uses comparative example 6, all to be adhered to per capita using 6 months.Remembered in the form of photo
Record compares the whitening effect and anti-aging effects before and after use using skin preceding and using rear privates.Opinion rating: whitening effect
Fruit is clearly 1 grade, and whitening effect is evident as 2 grades, and unobvious whitening effect is 3 grades, and it is 4 that whitening effect is very unobvious
Grade；Skin elasticity is clearly 1 grade, and skin elasticity is evident as 2 grades, and unobvious skin elasticity is 3 grades, and skin elasticity is very not
It is evident as 4 grades.
| Whitening effect | Skin elasticity | |
| 1st group | 1 | 1 |
| 2nd group | 1 | 1 |
| 3rd group | 1 | 1 |
| 4th group | 1 | 1 |
| 5th group | 1 | 1 |
| 6th group | 1 | 1 |
| 7th group | 1 | 1 |
| 8th group | 1 | 2 |
| 9th group | 2 | 2 |
| 10th group | 2 | 3 |
| 11st group | 4 | 4 |
| 12nd group | 4 | 4 |
| 13rd group | 3 | 4 |
| 14th group | 3 | 4 |
| 15th group | 4 | 4 |
| 16th group | 4 | 4 |
| 17th group | 3 | 4 |
The foregoing is only a preferred embodiment of the present invention, is not intended to limit the scope of the present invention.It is all
The equivalent changes and modifications that content is done according to the present invention are encompassed by the scope of the patents of the invention.
Claims (7)
1. auxotype women private portion conditioning liquid, which is characterized in that in parts by weight, include at least following components:
Amino acid in the N- acyl amino acid surfactant is selected from one of neutral amino acid or acidic amino acid, institute
Stating moisturizing composition includes hyaluronic acid and collagen, and the moisture-keeping composition includes aloe, glycerol；The hyaluronic acid
Average molecular weight be 50000-2200000Da, the weight ratio of the hyaluronic acid and collagen is 1:(50-100)；It is described
The weight ratio of aloe and glycerol is 1:(40-100)；The kinematic viscosity of the aloe is 0.5-1.5mm2/s.
2. auxotype women private portion as described in claim 1 conditioning liquid, which is characterized in that the structure of the N- acylamino acid
Formula are as follows:
R1For the alkyl containing 3-29 carbon atom, R2For hydrogen atom or the substituent group containing 1-20 carbon atom, X1For hydrogen atom,
One of alkali metal, alkaline-earth metal, ammonium, alkanolamine residue, N- alkyltaurate.
3. auxotype women private portion as described in claim 1 conditioning liquid, which is characterized in that the ammonia in the N- acylamino acid
Base acid is selected from phenylalanine, methionine, threonine, isoleucine, leucine, valine, alanine, tyrosine, positive figured silk fabrics ammonia
Acid, aspartic acid, serine, homoserine, cysteine, homocysteine, selenocystein, homocystine, cystine, paddy
At least one of propylhomoserin, glycine, homoisoleucine, nor-leucine.
4. auxotype women private portion as described in claim 1 conditioning liquid, which is characterized in that the acyl in the N- acylamino acid
Base is selected from lauroyl, cocoyl, myristoyl, palmityl, pearly-lustre fatty acyl group, stearyl, isostearoyl base, flower
Raw acyl group, behenyl acyl group, haze tallow acyl group, wax acyl group, melissa acyl group, fatty acid distribution of coconut oil acyl group, palm oil fatty acid acyl group, palm
At least one of kernel oil and fat fat acid acyl group, tallow fatty acids acyl group and hardening tallow fatty acids acyl group.
5. auxotype women private portion as described in claim 1 conditioning liquid, which is characterized in that the particle size of the nano silver is
1-20nm, the particle size of the Nano pearl powder are 200-800nm, and the particle size of the nano-tourmaline is 50-
100nm。
6. auxotype women private portion as described in claim 1 conditioning liquid, which is characterized in that the nanometer pollen by plant flower
It is grinding to obtain, the plant is selected from least one of rosaceae, composite family, Liliaceae.
7. a kind of preparation method of the auxotype women private portion conditioning liquid as described in any one of claim 1-6 claim,
It is characterized in that, comprising the following steps:
(1) N- acyl amino acid surfactant, aloe, glycerol, water are added in container A, heating stirring is uniform；
(2) nano-tourmaline, nano silver, Nano pearl powder, nanometer pollen, water are added in container B, stirs evenly at room temperature；
(3) mixture in container B pours into container A, sequentially adds hyaluronic acid, collagen at room temperature, stirs evenly
Filling afterwards, packaging.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102988231A (en) * | 2012-11-15 | 2013-03-27 | 隋丽梅 | Feminine care solution and preparation method thereof |
| CN103340816A (en) * | 2013-07-17 | 2013-10-09 | 深圳市妍倩科技有限公司 | Special private care wet tissue for women |
| CN103340765A (en) * | 2013-06-06 | 2013-10-09 | 金红叶纸业集团有限公司 | Skincare composition and life paper applying same |
| CN104352364A (en) * | 2014-11-11 | 2015-02-18 | 上海万淇生物科技有限公司 | Portable facial cleanser-containing wet tissue |
-
2016
- 2016-02-23 CN CN201610100802.9A patent/CN105663001B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102988231A (en) * | 2012-11-15 | 2013-03-27 | 隋丽梅 | Feminine care solution and preparation method thereof |
| CN103340765A (en) * | 2013-06-06 | 2013-10-09 | 金红叶纸业集团有限公司 | Skincare composition and life paper applying same |
| CN103340816A (en) * | 2013-07-17 | 2013-10-09 | 深圳市妍倩科技有限公司 | Special private care wet tissue for women |
| CN104352364A (en) * | 2014-11-11 | 2015-02-18 | 上海万淇生物科技有限公司 | Portable facial cleanser-containing wet tissue |
Non-Patent Citations (2)
| Title |
|---|
| N-酰基氨基酸系表面活性剂;王多闻;《日用化学工业》;19831231(第5期);第27-29页 |
| 氨基酸系表面活性剂;李忠义等;《辽宁化工》;19901213(第1期);第13-18页 |
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