CN105662915A - Dendrobium officinale small molecule peptide toothpaste based on nano-gold bar composite raw material - Google Patents
Dendrobium officinale small molecule peptide toothpaste based on nano-gold bar composite raw material Download PDFInfo
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- CN105662915A CN105662915A CN201610207244.6A CN201610207244A CN105662915A CN 105662915 A CN105662915 A CN 105662915A CN 201610207244 A CN201610207244 A CN 201610207244A CN 105662915 A CN105662915 A CN 105662915A
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- herba dendrobii
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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- Life Sciences & Earth Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses dendrobium officinale small molecule peptide toothpaste based on a nano-gold bar composite raw material, which comprises the following ingredients in parts by weight: 40-50 parts of sorbitol, 10-20 parts of water, 20-25 parts of silica gel, 8-12 parts of glycerol, 1-5 parts of dendrobium officinale small molecule peptide, 1-5 parts of nano-gold bar, 3-5 parts of polyethylene glycol 400, 0.8-1.2 parts of lauryl sodium sulfate, 0.8-1.2 parts of lauroyl sarcosine, 0.6-0.8 part of carboxymethyl cellulose sodium, 0.5-1.5 parts of edible essence, 0.1-0.3 part of carrageenin, 0.1-0.5 part of xylitol, 0.1-0.2 part of paeonol and 0.03-0.05 part of mica powder. According to the toothpaste disclosed by the invention, by adding the dendrobium officinale small molecule peptide and the nano-gold bar, the injured oral cavity can be repaired, bacterial reproduction can be inhibited, the peculiar smell of the oral cavity can be effectively prevented, and the teeth can be whitened; and the nano-gold bar can effectively deliver nutrient substances to directly arrive at the underlying skin and even penetrate through the skin to enter a human circulating system so as to effectively release active ingredients to achieve the corresponding purpose of protecting the teeth.
Description
Technical field
The present invention relates to the formulation art of makeup, specifically disclose a kind of Herba Dendrobii small-molecular peptides toothpaste based on nanometer gold bar compound material.
Background technology
In existing market, Herba Dendrobii mainly extracts polysaccharide for the preparation of medicine for oral administration, and the extraction and application for small-molecular peptides is then fewer. The present invention extracts Herba Dendrobii small-molecular peptides, for the preparation of toothpaste. Traditional pan-fried extraction method of boiling easily destroys Herba Dendrobii small-molecular peptides, and common polishing can comprise more impurity, is not easy to isolate small-molecular peptides. The efficiency that these ordinary methods obtain Herba Dendrobii small-molecular peptides is too low, and therefore we need to explore new method. Modern science shows, Herba Dendrobii small-molecular peptides has hemostasis, promotes the effect of wound healing, can outward for repairing damaged oral. Experiment proves, Herba Dendrobii small-molecular peptides can make stomatocace position obtain mechanical protection, strengthens anti-inflammation and the repair ability of oral cavity part mucous membrane, ulcer is healed sooner, can breed by anti-bacteria for oral cavity, can effectively prevent halitosis. And at present in the market, the occupation rate of Herba Dendrobii small-molecular peptides toothpaste is still very little, so Herba Dendrobii small-molecular peptides toothpaste has very big development prospect.
Scientific research shows, nanometer gold bar has desirable promotion skin absorption, and the physical property (photo-thermal effect etc.) of combining nano gold rod makes for toothpaste and gum can be made to become tight reality soft, flexible, full, prevents loss of tooth. Current goldleaf, Chang Zuowei food additives such as nanometer gold or be used as dietary supplements, are applied to the considerably less of toothpaste.
Summary of the invention
In order to solve the problems of the technologies described above, the present invention provides a kind of Herba Dendrobii small-molecular peptides toothpaste utilizing Herba Dendrobii small-molecular peptides to make.
The technical solution adopted in the present invention is:
A kind of Herba Dendrobii small-molecular peptides toothpaste, comprises the composition of following massfraction: Sorbitol Powder 40～50, water 10～20, silica dioxide gel 20～25, glycerine 8～12, Herba Dendrobii small-molecular peptides 1～5, nanometer gold bar 1～5, poly(oxyethylene glycol) 400 3～5, sodium lauryl sulphate 0.8～1.2, lauroyl sarcosine ammonium 0.8～1.2, sodium cellulose glycolate 0.6～0.8, food flavour are edible 0.5～1.5, carrageenin 0.1～0.3, Xylitol 0.1～0.5, Paeonol 0.1～0.2, mica powder 0.03～0.05.
Present invention adds Herba Dendrobii small-molecular peptides, can repair damaged oral, anti-bacteria is bred, and effectively prevents halitosis, tooth-whitening.
Further, described nanometer gold bar is prepared with in-situ method, taking modification Sargassum polysaccharides group block copolymer (SA-PVP) as stablizer.
Further, the consumption of described modification Sargassum polysaccharides group block copolymer is 11%.
Further, the mean diameter of described nanometer gold bar is about 10nm, and mean length is about 60nm.
Further, the preparation method of described Herba Dendrobii small-molecular peptides is: (1) adopts normal temperature high voltage pre-treatment Herba Dendrobii, obtains high degree of dispersion Herba Dendrobii pretreatment fluid; (2) small-molecular peptides enzymolysis solution is obtained with prozyme process; (3) the Herba Dendrobii small-molecular peptides lysate obtained is carried out purifying.
Further, described step (1) is specially: Herba Dendrobii is dried, and pulverizes, and crosses 60 order sieves, gained powder is added water, stir evenly, soak 1Omin and soften; Regulating cold cycle pump bound temperature to be-10 DEG C～-4 DEG C, mixture is poured into high pressure homogenizer, first material is poured under 5～l0MPa pressure conditions, and then regulated valve is to required pressure, and after pressure is stable, homogeneous is for several times; Centrifugal 20min when gained homogenizing fluid 4000r/min, collects supernatant liquor.
Further, described step (2) is specially: Sumizyme MP Alcalase2.4L, and enzymatic hydrolysis condition is: enzyme-to-substrate concentration ratio is 6%, temperature 50 DEG C, pH=8.5, and the reaction times is 8h; Or the enzymatic hydrolysis condition of trypsinase is: enzyme-to-substrate concentration ratio is 6%, temperature 42 DEG C, pH=8.0, the reaction times is 8h; Or Sumizyme MP 37017, enzymatic hydrolysis condition is: enzyme-to-substrate concentration ratio is 3%, temperature 50 DEG C, pH=8.5, and the reaction times is 8h.
Further, the molecular weight of described Herba Dendrobii small-molecular peptides is 1000～2000Da.
The present invention utilizes Meizhou distinguishing products Herba Dendrobii small-molecular peptides to be core; capture the commanding elevation of international modern agricultural development; utilize the normal temperature high voltage pre-treatment of integrated advanced person, complex enzyme hydrolysis, micro-filter, ultrafiltration and integrated technology thereof; build strong adaptability high efficiency separation Herba Dendrobii small-molecular peptides preparation technology; realize the preparation quick, efficient to Herba Dendrobii small-molecular peptides and mass-producing application; optimize toothpaste technical recipe, research and development Herba Dendrobii tooth paste product, and realize industrialization.
Nanometer gold penetrates efficiency height, stability height, active high, can effectively carry nutrition speciality go directly skin bottom, even pass through skin and enter human recycle system, effectively discharge activeconstituents, it is achieved protect the object of tooth accordingly. Herba Dendrobii small-molecular peptides can make stomatocace position obtain mechanical protection, strengthens anti-inflammation and the repair ability of oral cavity part mucous membrane, ulcer is healed sooner, can breed by anti-bacteria for oral cavity, can effectively prevent halitosis. The present invention utilizes and adds nanometer gold bar matrix material and Herba Dendrobii small-molecular peptides, optimizes toothpaste technical recipe, and realizes industrialization.
In order to understand better and implement, the following detailed description of the present invention.
Embodiment
The preparation of [embodiment 1] Herba Dendrobii small-molecular peptides
According to the constructional feature of Herba Dendrobii protein, adopt normal temperature high voltage preconditioning technique to obtain high degree of dispersion Herba Dendrobii pretreatment fluid specifically to operate: Herba Dendrobii dries (40 DEG C), pulverize, cross 60 order sieves, gained powder is added a certain proportion of water, stir evenly, soak lOmin and soften.Regulate cold cycle pump bound temperature to be-10 DEG C one-4 DEG C, ensure that clarifixator internal temperature is normal temperature. Pouring mixture into high pressure homogenizer, first under low pressure conditions (5-l0MPa), then regulated valve is to required pressure (40～50MPa) for material, and after pressure is stable, homogeneous is for several times; Centrifugal 20min when gained homogenizing fluid 4000r/min. Collecting supernatant liquor, residue is dried and is preserved.
Compound enzyme treatment technique is adopted to obtain small-molecular peptides enzymolysis solution, concrete condition: the enzymatic hydrolysis condition of Sumizyme MP Alcalase2.4L is: enzyme-to-substrate concentration ratio (E/S) is 6%, temperature 50 DEG C, pH=8.5, and the reaction times is 8h. The enzymatic hydrolysis condition of trypsinase is: enzyme-to-substrate concentration ratio (E/S) is 6%, temperature 42 DEG C, pH=8.0, and the reaction times is 8h. The enzymatic hydrolysis condition of Sumizyme MP 37017 is: enzyme-to-substrate concentration ratio (E/S) is 3%, temperature 50 DEG C, pH=8.5, and the reaction times is 8h.
Herba Dendrobii small-molecular peptides separating and purifying technology
According to the constructional feature of Herba Dendrobii small molecules, adopting the technology such as micro-filter, ultrafiltration and SephadexG desalting and purifying thereof to prepare Herba Dendrobii small-molecular peptides, final acquisition molecular weight is the Herba Dendrobii small-molecular peptides of 1000～2000Da.
The preparation of [embodiment 2] nanometer gold bar
The nanometer gold bar used in the present invention is prepared by in-situ method, taking modified polysaccharide group block copolymer SA-PVP as stablizer, wherein the consumption of SA-PVP is 11%, Sargassum polysaccharides unit in multipolymer SA-PVP has very strong complex ability, complex compound can be formed with polyvalent metal ion, effectively snatch away the heavy metal ion in skin. The mean diameter of the nanometer gold bar of preparation is about 10nm, and mean length is about 60nm, has obvious photo-thermal effect.
[embodiment 3] Herba Dendrobii small-molecular peptides tooth paste product is produced
It is TE-3 type Manufacturing medicine extract machine that this product prepares the instrument adopted, and with high speed homogenization device grinding material, disperses thickening material in powder stirring measuring chute, adopts dry method one-step technology, supporting OMRON Controlling System. Dry method single stage method paste manufacture process, first first mixes cementing agent powder with friction agent powder with mixing equipment, and with water in kneader device, glycerine solution is kneaded into cream together, stirs after evenly and adds spices again, other raw material such as whipping agent. After mixing preparation, canned can obtain finished product.
The production formula of the Herba Dendrobii small-molecular peptides toothpaste of the present invention is as follows:
[embodiment 3] quality product detects
[embodiment 4] efficacy evaluation
Methods for the treatment of: use the tooth that relaxes to reach sternly clear Dentifrice treatment group 82 example of mouth, man 40 example, female 42 example; Use metronidazole treatment control group 80 example, man 39 example, female 41 example. Advise patient to gargle before treatment, to keep oral cavity cleaning, blot the long-pending liquid of ulcer surface gently with sterilization cotton balls, treatment group is coated on ulcer surface while easypro tooth reaches the sternly clear toothpaste local uniform of mouth, pressing even gently with moistening cotton balls again, every day 3 to 4 times, taking after meal, bedtime medication is as good. Control group gives metronidazole paste, uses with method. By doctor's advice further consultation after medication.
Efficacy assessment standard:
Effective: after medication 2～3 days, ulcer healing, pain obviously alleviates or disappears, and ulcer surrounding tissue mucous hyperemia disappears, and ulcer surface has newborn epithelium to cover.
Effective: after medication 4～6 days, pain obviously alleviates or disappears, and ulcer surrounding tissue mucous hyperemia disappears, ulcer healing.
Invalid: medication is after 7 days, and local pain slightly alleviates or without obviously changing, ulcer has not yet to see obvious healing.
Calculate with effective and effective case and have efficiency.
Result for the treatment of
| Group | Effective | Effectively | Invalid | Always there is efficiency |
| Toothpaste group of the present invention | 47 | 35 | 0 | 100% |
| Metronidazole treatment group | 26 | 37 | 17 | 78.7% |
Have no adverse reaction temporarily
It may be seen that after using Herba Dendrobii small-molecular peptides toothpaste, oral conditions has improvement to a certain degree, illustrates that the effect of this product is obviously from above data.
The present invention is not limited to above-mentioned enforcement mode, if various change or distortion to the present invention do not depart from the spirit and scope of the present invention, if these are changed and are out of shape within the claim and equivalent technologies scope that belong to the present invention, then the present invention also is intended to comprise these changes and distortion.
Claims (9)
1. based on a Herba Dendrobii small-molecular peptides toothpaste for nanometer gold bar compound material, comprise the composition of following massfraction: Sorbitol Powder 40～50, water 10～20, silica dioxide gel 20～25, glycerine 8～12, Herba Dendrobii small-molecular peptides 1～5, nanometer gold bar 1～5, poly(oxyethylene glycol) 400 3～5, sodium lauryl sulphate 0.8～1.2, lauroyl sarcosine ammonium 0.8～1.2, sodium cellulose glycolate 0.6～0.8, food flavour are edible 0.5～1.5, carrageenin 0.1～0.3, Xylitol 0.1～0.5, Paeonol 0.1～0.2, mica powder 0.03～0.05.
2. Herba Dendrobii small-molecular peptides toothpaste according to claim 1, it is characterised in that, described nanometer gold bar is prepared with in-situ method, taking modification Sargassum polysaccharides group block copolymer (SA-PVP) as stablizer.
3. Herba Dendrobii small-molecular peptides toothpaste according to claim 1, it is characterised in that, the consumption of described modification Sargassum polysaccharides group block copolymer is 11%.
4. Herba Dendrobii small-molecular peptides toothpaste according to claim 1, it is characterised in that, the mean diameter of described nanometer gold bar is about 10nm, and mean length is about 60nm.
5. Herba Dendrobii small-molecular peptides toothpaste according to claim 1, it is characterised in that, the preparation method of described Herba Dendrobii small-molecular peptides is: (1) adopts normal temperature high voltage pre-treatment Herba Dendrobii, obtains high degree of dispersion Herba Dendrobii pretreatment fluid; (2) small-molecular peptides enzymolysis solution is obtained with prozyme process; (3) the Herba Dendrobii small-molecular peptides lysate obtained is carried out purifying.
6. Herba Dendrobii small-molecular peptides toothpaste according to claim 2, it is characterised in that, described step (1) is specially: Herba Dendrobii is dried, and pulverizes, and crosses 60 order sieves, gained powder is added water, stir evenly, soak 1Omin and soften; Regulating cold cycle pump bound temperature to be-10 DEG C～-4 DEG C, mixture is poured into high pressure homogenizer, first material is poured under 5～l0MPa pressure conditions, and then regulated valve is to required pressure, and after pressure is stable, homogeneous is for several times; Centrifugal 20min when gained homogenizing fluid 4000r/min, collects supernatant liquor.
7. Herba Dendrobii small-molecular peptides toothpaste according to claim 2, it is characterised in that, described step (2) is specially: Sumizyme MP Alcalase2.4L, enzymatic hydrolysis condition is: enzyme-to-substrate concentration ratio is 6%, temperature 50 DEG C, pH=8.5, the reaction times is 8h; Or the enzymatic hydrolysis condition of trypsinase is: enzyme-to-substrate concentration ratio is 6%, temperature 42 DEG C, pH=8.0, the reaction times is 8h; Or Sumizyme MP 37017, enzymatic hydrolysis condition is: enzyme-to-substrate concentration ratio is 3%, temperature 50 DEG C, pH=8.5, and the reaction times is 8h.
8. Herba Dendrobii small-molecular peptides toothpaste according to claim 2, it is characterised in that, the purification process in described step (3) comprises micro-filter, ultrafiltration and glucose gel purifying.
9. according to Herba Dendrobii small-molecular peptides toothpaste described in any bar in claim 1-8, it is characterised in that, the molecular weight of described Herba Dendrobii small-molecular peptides is 1000～2000Da.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610207244.6A CN105662915A (en) | 2016-04-01 | 2016-04-01 | Dendrobium officinale small molecule peptide toothpaste based on nano-gold bar composite raw material |
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| CN201610207244.6A CN105662915A (en) | 2016-04-01 | 2016-04-01 | Dendrobium officinale small molecule peptide toothpaste based on nano-gold bar composite raw material |
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| CN201610207244.6A Pending CN105662915A (en) | 2016-04-01 | 2016-04-01 | Dendrobium officinale small molecule peptide toothpaste based on nano-gold bar composite raw material |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111283214A (en) * | 2020-02-26 | 2020-06-16 | 西安工业大学 | Pure silver nanorod with hexagonal cross section and preparation method thereof |
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2016
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111283214A (en) * | 2020-02-26 | 2020-06-16 | 西安工业大学 | Pure silver nanorod with hexagonal cross section and preparation method thereof |
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