CN105662901A

CN105662901A - Novel vitiligo covering composition kit

Info

Publication number: CN105662901A
Application number: CN201610058872.2A
Authority: CN
Inventors: 胡发刚
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-01-28
Filing date: 2016-01-28
Publication date: 2016-06-15

Abstract

A novel vitiligo covering composition kit comprises a first package and a second package, wherein the first package contains dispersible tablets containing a vitiligo covering active agent, and the second package contains an aqueous liquid containing a water-soluble pigment. The pigment and the vitiligo covering active agent are placed in different packages, and the active substance is prevented from reacting with the pigment, so that vitiligo covering composition is stable in property, cannot change color, can realize quick covering and coloring effects and has a more lasting effect.

Description

A kind of novel vitiligo hides compositions box set

Technical field

The invention belongs to the cosmetic field that vitiligo hides, be specifically related to a kind of novel vitiligo and hide compositions box set. This vitiligo hides compositions and has covering white macula beautifying skin function, and it is relative to existing covering agent, stable in properties, invariant color, thus reaching quickly to hide and can painted more lasting effect.

Background technology

Vitiligo (vitiligo) is a kind of common multiple pigmented dermatosis. This disease forms white macula for feature with local or general property depigmentation, is the common skin diseases of an impact beauty treatment, has the feature of easy diagnosis, treatment difficulty. Vitiligo all has generation all over the world, and China there are about million people morbidity, and sickness rate is about 1%-2%, is one of big pertinacious disease of world's dermatosis three. At present, leukodermic Therapeutic Method is varied, including Western medicine therapy, herbal treatment, physiotherapy and operative therapy etc. But, owing to leucoderma disease is because of complexity, its pathogeny not yet completely clearly, therefore effectively treats vitiligo extremely difficult at present. Occurring with head, face, neck and limb end owing to leukodermic affected part is many, therefore, dressing is difficult to hide the white macula of patient, and this significantly impacts the daily life of patients with vitiligo.

Along with the development of medical cosmetology, people begin at and cosmetically vitiligo are made up or covering treatment, utilize the hyperchromic effect of some composition, make white macula recover normal skin tone. External vitiligo preparation common at present is roughly divided into following four classes: one, the Chinese medicine being representative with Fructus Psoraleae, and this kind of material contains photosensitization active component, is irradiated by light melanin can be excited to generate after being applied to skin; Two, corticosteroid formulations, immunoreation the vitiligo caused can be told on by corticosteroid hormone preparation; Three, beautifying drug, for instance chlormethine, dihydroxy acetone etc.; Four, pigment toner, it forms cream or unguentum with cosmetic base, is coated on white macula thus playing covering effect. In this four classes external preparation, Chinese medicine ingredients onset is slow, and corticosteroid is as hormone, and life-time service can produce serious side effect. Accordingly, it is capable to quickly add lustre to skin become, without the medicine class external preparation producing apparent side effect, the focus that white macula hides. Such as, Zhang Qiliang edit, " medical cosmetology ", 1996 the 1st edition, disclose 5% dihydroxy acetone solution and 15% silver nitrate solution, repeat painting and put on the skin, white macula can be made to dye. Section sunrise institute etc., " therapy of vitiligo present situation ", " Chengde Medical College's journal ", the 11st volume the 2nd phase in 1994, discloses dihydroxy acetone and is applied to white macula place, its effect with horn cell, producing color and luster, 5% dihydroxy acetone is applied to white macula place, and every day is repeatedly, smearing continuously, after coating, color can keep 2-3 days.Guo Suizhang, " leucoderma medicament treatment general introduction ", " straits medicine ", the 10th volume the 3rd phase in 1998, disclose 2% dihydroxy acetone complex liquid (containing dihydroxy acetone 2.0, vitamin B12 00mg, add dimethyl sulfoxide 100ml) and treat vitiligo. Li Gang etc., " 5% dihydroxy acetone frost external curing vitiligo 46 example observation of curative effect ", " work enterprise doctor's periodical ", the 17th volume the 2nd phase in 2004, disclose and 25g dihydroxy acetone is dissolved in 475g cream base, be formulated as 5% dihydroxy acetone frost.

In the last few years, have also appeared the patented technology that numerous vitiligo hides both at home and abroad, such as Chinese patent application 99114078.8 discloses a kind of externally-applied medicinal composition, and it is made up of mustine hydrochlcride, dihydroxyacetone, the ethanol extraction of Fructus Psoraleae Flos Carthami and laurocapram. 200610137625.8 also disclose one to treat skin pigment reduction external used medicine, it is made up of ethanol, Radix Polygoni Multiflori, Fructus Psoraleae, the Flos Sophorae Immaturus, dihydroxyacetone. 201210032196.3 disclose a kind of leukoderma covering agent, for Masking sol or covering frost; Mainly comprising of described Masking sol includes: 1,2-propylene glycol, jojoba ester, preservative, surfactant, vitamin E acetate, C3H6O3, food coloring and deionized water. 201210303530.4 disclose a kind of deep-sea Sargassum extract with vitiligo covering effect, it utilizes multiple algae to carry out extracting thus obtaining the active substance that vitiliginous skin can be made to add lustre to, and comprises the covering compositions of this extract. 200410070380.2 disclose a kind of leukoderma covering agent, it is made up of 1 portion of food coloring, 6-10 part essence, 80-100 dihydroxy acetone, 30-50 part ethanol, 1500-1800 part water.

From current covering product, emulsion-type is due to the existence of oil, sensuously salubrious not using, and one very big problem of Emulsion is to be not easy to smear uniformly, producing color lump on vitiliginous skin, affect attractive in appearance, therefore solution-type hides what product was best suited for. And for solution-type product, in order to reach the purpose hiding immediately and indicating, water colo(u)r is to hide the indispensable composition of product, but the active substance owing to hiding in product is very sensitive to the character of other composition in light, heat, humidity, pH value and product, cause that product is highly unstable, the most obvious phenomenon is that colorability is deteriorated, two is that product colour changes, use rear and normal skin tone is inconsistent, the purpose hidden immediately can not be reached, three is that product can produce strange taste so that user is difficult to accept. General liquid type product will produce obvious color change after preparation completes half a year, and with falling sharply of active substance, colorability is remarkably decreased. Such product that results in is but without being sold to consumer on hand, and product is it is possible to spent effect duration. Research for many years through the present inventor, it has been found that cause that the reason hiding product variable color, usefulness reduces is that the materials such as the pigment in dihydroxy acetone and product react. Accordingly, it would be desirable to develop a kind of stable, there is again the product hidden immediately with long-acting covering.

Summary of the invention

In order to overcome the problems referred to above, the inventors discovered that, by Masking sol separately packaging, other materials such as dihydroxy acetone isoreactivity material is placed in the first packaging, water colo(u)r are placed in the second packaging, when consumer needs to use, again both are mixed, so can avoid the reaction of product dihydroxy acetone isoreactivity material and pigment, solve the problem that shelf life is unstable, drastically increase the effect duration of Masking sol, reach the function hidden immediately with long-acting covering.

Therefore, it is an object of the present invention to provide a kind of novel vitiligo and hide compositions box set, it comprises the first packaging and the second packaging, it it is the dispersible tablet hiding activating agent containing vitiligo in first packaging, wherein leukoderma covering agent accounts for the 3%-10% of Masking sol gross weight, for comprising the waterborne liquid of water colo(u)r in second packaging, wherein water colo(u)r accounts for the 0.05%-0.3% of Masking sol.

Dispersible tablet therein comprises vitiligo and hides activating agent, filler, binding agent, disintegrating agent and lubricant, leukoderma covering agent accounts for the 35%-65% of dispersible tablet, filler accounts for the 30%-45% of dispersible tablet, binding agent accounts for the 1%-10% of dispersible tablet, disintegrating agent accounts for the 1%-10% of dispersible tablet, and lubricant accounts for the 1%-5% of dispersible tablet.

Filler therein is selected from mannitol, xylitol, sorbitol, maltol, maltose alcohol, lactose, microcrystalline Cellulose, starch, pregelatinized Starch, glucose, maltose, cyclodextrin and their combination.

Binding agent therein is selected from polyvinylpyrrolidone, methylcellulose, sodium carboxymethyl cellulose, maltodextrin, pectin, xanthan gum, alginic acid, modified alginic acid and their combination.

Disintegrating agent therein is selected from crospolyvinylpyrrolidone, sodium starch glycolate, the carboxymethyl cellulose of crosslinking, carboxymethyl starch sodium, the hydroxypropyl cellulose of low replacement and their combination.

Lubricant at least one in magnesium stearate, silicon dioxide, Pulvis Talci, stearic acid.

Wherein vitiligo hides activating agent is dihydroxy acetone.

Water colo(u)r therein is carmine, amaranth, lemon yellow, sunset yellow, light blue, erythrosine, indigo, light blue, newly red and mixture, it is preferable that the mixture of carmine, sunset yellow and light blue, its ratio is 2:15:1.

Vitiligo Masking sol box set according to the present invention, it is characterized in that comprising Erythrulose, glyceraldehyde, silver nitrate, chlormethine, corticosteroid, deep-sea Sargassum extract, lawsone, juglone or its mixture further as painted reinforcing agent in the first and/or second packaging, prepared by the method that deep-sea therein Sargassum extract is recorded with the present inventor's granted patent 201210303530.4.

Vitiligo Masking sol box set according to the present invention, it is characterised in that comprise wetting agent, antioxidant, chelating agen, preservative, flavouring agent or their combination further in the first and/or second packaging.

It is a further object of the present invention to provide the leukodermic cosmetic method of a kind of covering, including using the Masking sol using the present invention at vitiligo disease sites.

Accompanying drawing explanation

Fig. 1 is the appearance figure of reference examples 1;

Fig. 2 is the appearance figure of embodiment 1;

Fig. 3 is the design sketch after reference examples 1 room temperature places half a year;

Fig. 4 is that embodiment 1 room temperature places the design sketch being made into Masking sol half a year;

Fig. 5 is the design sketch after placing 4 weeks at reference examples 1 couveuse 45 DEG C;

Fig. 6 is the design sketch being made into Masking sol after placing 4 weeks at embodiment 1 couveuse 45 DEG C.

Detailed description of the invention

Embodiment 1

Dihydroxy acetone effervescent tablet forms: dihydroxy acetone 5g, sucrose 3g, polyvinylpyrrolidone 0.3g, carboxymethyl starch sodium 0.2g, magnesium stearate 0.1g, by above-mentioned raw materials through soft material processed, pelletize, dry, tableting step make dispersible tablet, are loaded in the first packaging;

Take 2g ethanol, 0.1g water solublity food coloring and the mixing of 89.3g water and be placed in the second packaging;

First packaging and the second packaging are put into packing box, obtains the box set of the present invention.

Embodiment 2

Dihydroxy acetone effervescent tablet forms: dihydroxy acetone 3g, lactose 3g, maltodextrin 0.2g, carboxymethyl starch sodium 0.4g, magnesium stearate 0.1g, by above-mentioned raw materials through soft material processed, pelletize, dry, tableting step makes dispersible tablet, is loaded in the first packaging;

Take 2g ethanol, 0.3g water solublity food coloring and the mixing of 91g water and be placed in the second packaging;

Embodiment 3

Dihydroxy acetone effervescent tablet forms: dihydroxy acetone 10g, sucrose 8g, sodium carboxymethyl cellulose 1g, crospolyvinylpyrrolidone 0.5g, magnesium stearate 0.3g, by above-mentioned raw materials through soft material processed, pelletize, dry, tableting step make dispersible tablet, are loaded in the first packaging;

Take 5g ethanol, 0.2g water solublity food coloring and the mixing of 75g water and be placed in the second packaging;

Embodiment 4

Dihydroxy acetone effervescent tablet forms: dihydroxy acetone 8g, microcrystalline Cellulose 4g, polyvinylpyrrolidone 0.5g, carboxymethyl starch sodium 0.5g, magnesium stearate 0.2g, by above-mentioned raw materials through soft material processed, pelletize, dry, tableting step make dispersible tablet, are loaded in the first packaging;

Take 2g ethanol, 0.1g water solublity food coloring and the mixing of 84.7g water and be placed in the second packaging;

Embodiment 5

Dihydroxy acetone effervescent tablet forms: dihydroxy acetone 4.5g, sucrose 4.5g, polyvinylpyrrolidone 0.5g, carboxymethyl starch sodium 0.5g, magnesium stearate 0.1g, by above-mentioned raw materials through soft material processed, pelletize, dry, tableting step make dispersible tablet, are loaded in the first packaging;

Take 1g ethanol, 0.1g water solublity food coloring and the mixing of 76.8g water and be placed in the second packaging;

Embodiment 6 vitiligo hides the preparation of compositions

Dihydroxy acetone effervescent tablet forms: dihydroxy acetone 6g, glucose 4g, polyvinylpyrrolidone 1g, carboxymethyl starch sodium 1g, magnesium stearate 0.3g, by above-mentioned raw materials through soft material processed, pelletize, dry, tableting step make dispersible tablet, are loaded in the first packaging;

Take 4g ethanol, 0.1g water solublity food coloring and the mixing of 83.6g water and be placed in the second packaging;

Reference examples 1

Take 5g dihydroxy acetone, 2g ethanol, 0.1g water colo(u)r and the mixing of 92.9g water, both obtained vitiligo and hidden activating agent.

Effect example 1

Taking the sample of the covering agent of reference examples 1 and embodiment 1, after placing half a year at normal temperatures, reference examples 1 has been changed to bottle green, and embodiment 1 does not change, and effect is shown in Fig. 1-2.

Effect example 2

Taking the sample of the covering agent of reference examples 1 and embodiment 1, place 4 weeks at couveuse 45 DEG C, reference examples 1 has become fades to light green color, and embodiment 1 does not change, and effect is shown in Fig. 3-4.

Effect example 3

Activity substance content measures

1) weigh 1,2,4,6,8 and 10g dihydroxy acetone standard substance, be respectively placed in 100ml volumetric flask, be diluted to scale with the acetonitrile solution of 80%, both obtain standard substance;

2) chromatographic condition: HILIC chromatographic column (4.6mm × 250mm, 5 μm); Mobile phase is acetonitrile: ammonium acetate solution (5mmol/L)=92:8;Flow velocity is 1.0mL/min; Detection wavelength is 272nm; Sample size is 10 μ L;

3) standard substance 10 μ L is taken respectively, inject in high performance liquid chromatograph, drawing standard curve, then take 10 μ L reference examples 1 respectively, embodiment 1, room temperature place the reference examples 1 after half a year and embodiment 1, reference examples 1 and the embodiment 1 of 4 weeks is placed at couveuse 45 DEG C, injecting chromatographic column, calculate the content of dihydroxy acetone in each sample, result is as shown in table 1:

Table 1: dihydroxy acetone content

Stability and coloring effect experiment

Use reference examples 1, embodiment 1, room temperature place the reference examples 1 after half a year and embodiment 1 respectively, and white macula is dyeed by reference examples 1 and the embodiment 1 placed at couveuse 45 DEG C 4 weeks, records normal complexion lasting effects, shown in result table 2:

Table 2: painted and persistency

The above results shows, the Masking sol of reference examples 1 and embodiment 1 is when just preparing, owing to dihydroxy acetone content is suitable, coloring effect is as broad as long, but after placing half a year, the Masking sol of reference examples 1 has turned green, it is impossible to keep consistent with the colour of skin, smear color only within 1 week, to be just wholly absent, placing after 4 weeks for 45 DEG C, reference examples 1 has become green completely, it is impossible to play the effect hidden immediately, and due to the basic approach exhaustion of dihydroxy acetone, so there is no the coloring effect of dihydroxy acetone. And the Masking sol of embodiment 1, placing after being still accelerated experiment in couveuse half a year, its appearance color does not have significant change, and colorability also has essentially no difference, the Masking sol of the visible present invention significantly improves stability, and keeps quick-acting with the long-acting covering effect of Masking sol.

Claims

1. a novel vitiligo hides compositions box set, it comprises the first packaging and the second packaging, it it is the dispersible tablet hiding activating agent containing vitiligo in first packaging, wherein leukoderma covering agent accounts for the 3%-10% of Masking sol gross weight, for comprising the waterborne liquid of water and water colo(u)r in second packaging, wherein water colo(u)r accounts for the 0.05%-0.3% of Masking sol.

2. vitiligo according to claim 1 hides compositions box set, dispersible tablet therein comprises vitiligo and hides activating agent, filler, binding agent, disintegrating agent and lubricant, leukoderma covering agent accounts for the 35%-65% of dispersible tablet, filler accounts for the 30%-45% of dispersible tablet, binding agent accounts for the 1%-10% of dispersible tablet, disintegrating agent accounts for the 1%-10% of dispersible tablet, and lubricant accounts for the 1%-5% of dispersible tablet.

3. vitiligo according to claim 2 hides compositions box set, filler therein is selected from mannitol, xylitol, sorbitol, maltol, maltose alcohol, lactose, microcrystalline Cellulose, starch, pregelatinized Starch, glucose, maltose, cyclodextrin and their combination, binding agent is selected from polyvinylpyrrolidone, methylcellulose, sodium carboxymethyl cellulose, maltodextrin, pectin, xanthan gum, alginic acid, modified alginic acid, and their combination, disintegrating agent is selected from crospolyvinylpyrrolidone, sodium starch glycolate, the carboxymethyl cellulose of crosslinking, carboxymethyl starch sodium, the hydroxypropyl cellulose of low replacement and their combination, lubricant is selected from magnesium stearate, silicon dioxide, Pulvis Talci, at least one in stearic acid.

4. vitiligo according to claim 1 hides compositions box set, and wherein vitiligo hides activating agent is dihydroxy acetone.

5. vitiligo according to claim 1 hides compositions box set, and wherein water colo(u)r is selected from carmine, amaranth, lemon yellow, sunset yellow, light blue, erythrosine, indigo, light blue, newly red and mixture.

6. vitiligo according to claim 1 hides compositions box set, and wherein water colo(u)r is the mixture of carmine, sunset yellow and light blue, and its ratio is 2:15:1.

7. vitiligo according to claim 1 hides compositions box set, it is characterised in that comprise Erythrulose, glyceraldehyde, silver nitrate, chlormethine, corticosteroid, deep-sea Sargassum extract, lawsone, juglone or its mixture further as painted reinforcing agent in the first and/or second packaging.

8. vitiligo according to claim 1 hides compositions box set, it is characterised in that comprise wetting agent, antioxidant, chelating agen, preservative, flavouring agent or their combination further in the first and/or second packaging.

9. hide a leukodermic cosmetic method, hide compositions including the vitiligo using claim 1-8 at vitiligo disease sites.