CN105560075A

CN105560075A - Novel vitiligo covering composition kit

Info

Publication number: CN105560075A
Application number: CN201610058882.6A
Authority: CN
Inventors: 胡发刚
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-01-28
Filing date: 2016-01-28
Publication date: 2016-05-11

Abstract

A more-stable and long-acting vitiligo covering liquid kit comprises a first pack and a second pack; the first pack contains particles containing a vitiligo covering active agent; the second pack contains water-based liquid containing water-soluble pigment. By placing the pigment and the vitiligo covering active agent in different packs, it is avoided that the active agent and the pigment react, a vitiligo covering composition is sable in property and free of color changes, and the effects that covering is fast and color lasts longer can be achieved.

Description

A kind of novel vitiligo hides compositions cover box

Technical field

The invention belongs to the cosmetic field that vitiligo hides, be specifically related to a kind of novel vitiligo and hide compositions cover box.This vitiligo hides compositions to be had and hides white macula beautifying skin function, and it is relative to existing covering agent, stable in properties, invariant color, thus reaches and can to hide fast and can painted more lasting effect.

Background technology

Vitiligo (vitiligo) is a kind of common multiple pigmented dermatosis.This disease forms white macula for feature with local or general property depigmentation, is the common skin diseases of an impact beauty treatment, has the feature of easy diagnosis, treatment difficulty.Vitiligo all has generation all over the world, and about there is ten million people's morbidity in China, and sickness rate is about 1%-2%, is one of large pertinacious disease of world's dermatosis three.At present, leukodermic Therapeutic Method is varied, comprising Western medicine therapy, herbal treatment, physiotherapy and operative therapy etc.But because leucoderma disease is because of complexity, its pathogeny is not yet completely clear and definite at present, and therefore treatment vitiligo is quite difficult effectively.Because leukodermic affected part occurs mainly with head, face, neck and limb end, therefore, dressing is difficult to the white macula hiding patient, this extreme influence daily life of patients with vitiligo.

Along with the development of medical cosmetology, people start cosmetically making up or covering treatment to vitiligo, utilize the hyperchromic effect of some composition, make white macula recover normal skin tone.External vitiligo preparation common is at present roughly divided into following four classes: the Chinese medicine one, with Fructus Psoraleae being representative, and this kind of material contains photosensitization active component, is irradiated melanin can be excited to generate after being applied to skin by light; Two, corticosteroid formulations, corticosteroid hormone preparation can tell on to the vitiligo caused by immunoreation; Three, beautifying drug, such as chlormethine, dihydroxy acetone etc.; Four, pigment toner, itself and cosmetic base form cream or unguentum, to be coated on white macula thus to play covering effect.In this four classes external preparation, Chinese medicine ingredients onset is slow, and corticosteroid is as hormone, and life-time service can produce serious side effect.Therefore, to add lustre to fast with skin and don't the medicine class external preparation that can produce apparent side effect becomes the focus that white macula hides.Such as, Zhang Qiliang edit, " medical cosmetology ", 1996 the 1st edition, disclose 5% dihydroxy acetone solution and 15% silver nitrate solution, repeat painting and put on the skin, white macula can be made to dye.Section sunrise institute etc., " therapy of vitiligo present situation ", " Chengde Medical College's journal ", the 11st volume the 2nd phase in 1994, discloses dihydroxy acetone and is applied to white macula place, the effect of itself and horn cell, can produce color and luster, 5% dihydroxy acetone is applied to white macula place, and every day repeatedly, smear continuously, after coating, color can keep 2-3 days.Guo Suizhang, " leucoderma medicament treatment general introduction ", " straits medicine ", the 10th volume the 3rd phase in 1998, discloses 2% dihydroxy acetone complex liquid (containing dihydroxy acetone 2.0, vitamin B12 00mg, adds dimethyl sulfoxide 100ml) and treats vitiligo.Li Gangs etc., " the routine observation of curative effect of 5% dihydroxy acetone frost external curing vitiligo 46 ", " work enterprise doctor periodical ", the 17th volume the 2nd phase in 2004, discloses and is dissolved in 475g cream base by 25g dihydroxy acetone, is formulated as 5% dihydroxy acetone frost.

In the last few years, have also appeared the patented technology that numerous vitiligo hides both at home and abroad, such as Chinese patent application 99114078.8 discloses a kind of externally-applied medicinal composition, and it is made up of the ethanol extraction of mustine hydrochlcride, dihydroxyacetone, Fructus Psoraleae Flos Carthami and laurocapram.200610137625.8 also disclose one treats skin pigment reduction external used medicine, and it is made up of ethanol, Radix Polygoni Multiflori, Fructus Psoraleae, the Flos Sophorae Immaturus, dihydroxyacetone.201210032196.3 disclose a kind of leukoderma covering agent, be Masking sol or covering frost; The main composition of described Masking sol comprises: 1,2-PD, Jojoba ester, antiseptic, surfactant, vitamin E acetate, 1,3-Dihydroxyacetone, food coloring and deionized water.201210303530.4 disclose a kind of deep-sea Sargassum extract with vitiligo covering effect, and it utilizes multiple algae carry out extracting thus obtain the active substance that vitiliginous skin can be made to add lustre to, and comprises the covering compositions of this extract.200410070380.2 disclose a kind of leukoderma covering agent, are made up of 1 portion of food coloring, 6-10 part essence, 80-100 dihydroxy acetone, 30-50 part ethanol, 1500-1800 part water.

From current covering product, emulsion-type is due to the existence of oil, sensuously salubrious not in use, and Emulsion very large problem is not easy to smear evenly, can produce color lump on vitiliginous skin, affect attractive in appearance, therefore solution-type covering product is best suited for.And for solution-type product, in order to reach the object hiding immediately and indicate, water colo(u)r hides the indispensable composition of product, but because the active substance hidden in product is very sensitive to the character of other composition in light, heat, humidity, pH value and product, cause product very unstable, the most obvious phenomenon is that colorability is deteriorated, two is that product colour changes, after using and normal skin tone inconsistent, the object hidden immediately can not be reached, three is that product can produce strange taste, makes user be difficult to accept.General liquid type product will produce obvious color change after preparation completes half a year, and with falling sharply of active substance, colorability significantly declines.Such result causes product not also to be sold to consumer on hand, and product just may spend effect duration.Through the research for many years of the present inventor, find to cause the reason hiding product variable color, usefulness reduces to be that the materials such as pigment in dihydroxy acetone and product react.Therefore, need exploitation a kind of stable, there is again the product of covering and long-acting covering immediately.

Summary of the invention

In order to overcome the problems referred to above, the present inventor finds, by Masking sol separately packaging, dihydroxy acetone isoreactivity material is placed in the first packaging, and other material such as water colo(u)r is placed in the second packaging, when consumer needs to use, again both are mixed, the reaction of product dihydroxy acetone isoreactivity material and pigment can be avoided like this, solve the problem of shelf life instability, drastically increase the effect duration of Masking sol, reach the function of covering and long-acting covering immediately.

Therefore, an object of the present invention is to provide a kind of novel vitiligo and hide compositions cover box, it comprises the first packaging and the second packaging, first is packaged as containing the agent of vitiligo covering active agent particle, wherein leukoderma covering agent accounts for the 3%-10% of Masking sol gross weight, for comprising the waterborne liquid of water and water colo(u)r in second packaging, wherein water colo(u)r accounts for the 0.05%-0.3% of Masking sol.

The adjuvant of leukoderma covering agent granule is wherein Polyethylene Glycol, hydroxypropyl cellulose and filler, the ratio of leukoderma covering agent and adjuvant is 1:1-3, the ratio of Polyethylene Glycol and hydroxypropyl cellulose is 2:1, and filler is one or more in lactose, mannitol, sucrose, microcrystalline Cellulose, starch, pregelatinized Starch, dextrin, glucose, sorbitol, calcium carbonate, calcium sulfate, calcium hydrogen phosphate, calcium phosphate, hydroxypropyl emthylcellulose.

Wherein vitiligo hides activating agent and is selected from dihydroxy acetone.

Water colo(u)r is wherein carmine, amaranth, lemon yellow, sunset yellow, light blue, erythrosine, indigo, light blue, newly red and composition thereof, and the mixture of preferred carmine, sunset yellow and light blue, its ratio is 2:15:1.

According to vitiligo Masking sol cover box of the present invention, it is characterized in that comprising Erythrulose, glyceraldehyde, silver nitrate, chlormethine, corticosteroid, deep-sea Sargassum extract, lawsone, juglone or its mixture further as painted reinforcing agent in the first and/or second packaging.

According to vitiligo Masking sol cover box of the present invention, it is characterized in that comprising wetting agent, antioxidant, chelating agen, antiseptic, flavouring agent or their combination further in the first and/or second packaging.

Another object of the present invention is to provide the leukodermic cosmetic method of a kind of covering, is included in vitiligo disease sites and uses use Masking sol of the present invention.

Accompanying drawing explanation

Fig. 1 is the appearance figure of reference examples 1;

Fig. 2 is the design sketch after reference examples 1 room temperature places half a year;

Fig. 3 places the design sketch after 4 weeks at reference examples 1 couveuse 45 DEG C.

Detailed description of the invention

Embodiment 1

Get the mixing of 5g dihydroxy acetone, 2g Macrogol 2000,1g hydroxypropyl cellulose and 3g lactose, granulate after adding suitable quantity of water moistening, gained granule loads in the first packaging after granulate, drying;

Getting the mixing of 2g ethanol, 0.1g water solublity food coloring and 86.9g water is placed in the second packaging;

First packaging and the second packaging are put into packing box and namely obtains cover box of the present invention.

Embodiment 2

Get the mixing of 3g dihydroxy acetone, 2g Macrogol 2000,1g hydroxypropyl cellulose and 3g sucrose, granulate after adding suitable quantity of water moistening, gained granule loads in the first packaging after granulate, drying;

Getting the mixing of 2g ethanol, 0.2g water solublity food coloring and 88.8g water is placed in the second packaging;

Embodiment 3

Get the mixing of 10g dihydroxy acetone, 4g Macrogol 2000,2g hydroxypropyl cellulose and 5g microcrystalline Cellulose, granulate after adding suitable quantity of water moistening, gained granule loads in the first packaging after granulate, drying;

Getting the mixing of 2g ethanol, 0.3g water solublity food coloring and 76.9g water is placed in the second packaging;

Embodiment 4

Get the mixing of 4g dihydroxy acetone, 3g Macrogol 2000,1.5g hydroxypropyl cellulose and 1.5g sorbitol, granulate after adding suitable quantity of water moistening, gained granule loads in the first packaging after granulate, drying;

Getting the mixing of 2g ethanol, 0.1g water solublity food coloring and 87.9g water is placed in the second packaging;

Embodiment 5

Get the mixing of 6g dihydroxy acetone, 2g Macrogol 2000,1g hydroxypropyl cellulose and 3g glucose, granulate after adding suitable quantity of water moistening, gained granule loads in the first packaging after granulate, drying;

Getting the mixing of 2g ethanol, 0.1g water solublity food coloring and 85.9g water is placed in the second packaging;

Embodiment 6 vitiligo hides the preparation of compositions

Get the mixing of 8g dihydroxy acetone, 2g Macrogol 2000,1g hydroxypropyl cellulose and 7g mannitol, granulate after adding suitable quantity of water moistening, gained granule loads in the first packaging after granulate, drying;

Getting the mixing of 2g ethanol, 0.1g water solublity food coloring and 79.9g water is placed in the second packaging;

Reference examples 1

Get the mixing of 5g dihydroxy acetone, 2g ethanol, 0.1g water colo(u)r and 92.9g water, both obtained vitiligo and hidden activating agent.

Effect example

Activity substance content measures

1) take 1,2,4,6,8 and 10g dihydroxy acetone standard substance, be placed in 100ml volumetric flask respectively, be diluted to scale with the acetonitrile solution of 80%, both obtain standard substance;

2) chromatographic condition: HILIC chromatographic column (4.6mm × 250mm, 5 μm); Mobile phase is acetonitrile: ammonium acetate solution (5mmol/L)=92:8; Flow velocity is 1.0mL/min; Determined wavelength is 272nm; Sample size is 10 μ L;

3) standard substance 10 μ L is got respectively, inject high performance liquid chromatograph, drawing standard curve, then get 10 μ L reference examples 1 respectively, embodiment 1, room temperature place the reference examples 1 after half a year, room temperature places 4 weeks embodiments 1 at placing 4 weeks reference examples 1 and couveuse 45 DEG C at placing the embodiment 1 after half a year, couveuse 45 DEG C, inject chromatographic column, calculate the content of dihydroxy acetone in each sample, result is as shown in table 1:

Table 1: dihydroxy acetone content

Stability and coloring effect experiment

Use reference examples 1, embodiment 1, room temperature place the reference examples 1 after half a year and embodiment 1 respectively, and reference examples 1 and embodiment 1 pair of white macula of placing at couveuse 45 DEG C 4 weeks dye, and record normal complexion lasting effects, shown in result table 2:

Table 2: painted and persistency

The above results show, the Masking sol of reference examples 1 and embodiment 1 when just preparing, because dihydroxy acetone content is suitable, coloring effect is as broad as long, but after placing half a year, the Masking sol of reference examples 1 has turned green, can not be consistent with the colour of skin, smear color only within 1 week, just to disappear completely, place after 4 weeks for 45 DEG C, reference examples 1 becomes green completely, cannot play the effect hidden immediately, and due to the basic approach exhaustion of dihydroxy acetone, so there is no the coloring effect of dihydroxy acetone.And the Masking sol of embodiment 1, place after still carrying out Acceleration study in couveuse half a year, its appearance color does not have significant change, and colorability does not have difference substantially yet, visible Masking sol of the present invention significantly improves stability, and the covering effect keeping Masking sol quick-acting with long-acting.

Claims

1. a novel vitiligo hides compositions cover box, it comprises the first packaging and the second packaging, first is packaged as containing the agent of vitiligo covering active agent particle, wherein leukoderma covering agent accounts for the 3%-10% of Masking sol gross weight, for comprising the waterborne liquid of water and water colo(u)r in second packaging, wherein water colo(u)r accounts for the 0.05%-0.3% of Masking sol.

2. novel vitiligo according to claim 1 hides compositions cover box, wherein the adjuvant of leukoderma covering agent granule is Polyethylene Glycol, hydroxypropyl cellulose and filler, the ratio of leukoderma covering agent and adjuvant is 1:1-3, and the ratio of Polyethylene Glycol and hydroxypropyl cellulose is 2:1.

3. novel vitiligo according to claim 2 hides compositions cover box, and filler is wherein one or more in lactose, mannitol, sucrose, microcrystalline Cellulose, starch, pregelatinized Starch, dextrin, glucose, sorbitol, calcium carbonate, calcium sulfate, calcium hydrogen phosphate, calcium phosphate, hydroxypropyl emthylcellulose.

4. novel vitiligo according to claim 1 hides compositions cover box, and wherein vitiligo hides activating agent is dihydroxy acetone.

5. novel vitiligo according to claim 1 hides compositions cover box, and wherein water colo(u)r is selected from carmine, amaranth, lemon yellow, sunset yellow, light blue, erythrosine, indigo, light blue, newly red and composition thereof.

6. novel vitiligo according to claim 1 hides compositions cover box, and wherein water colo(u)r is the mixture of carmine, sunset yellow and light blue, and its ratio is 2:15:1.

7. novel vitiligo according to claim 1 hides compositions cover box, it is characterized in that comprising Erythrulose, glyceraldehyde, silver nitrate, chlormethine, corticosteroid, deep-sea Sargassum extract, lawsone, juglone or its mixture further as painted reinforcing agent in the first and/or second packaging.

8. novel vitiligo according to claim 1 hides compositions cover box, it is characterized in that comprising wetting agent, antioxidant, chelating agen, antiseptic, flavouring agent or their combination further in the first and/or second packaging.

9. hide a leukodermic cosmetic method, be included in the vitiligo covering compositions that vitiligo disease sites uses claim 1-8.