CN105596226A

CN105596226A - Novel leucoderma covering composition kit

Info

Publication number: CN105596226A
Application number: CN201610058875.6A
Authority: CN
Inventors: 胡发刚
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-01-28
Filing date: 2016-01-28
Publication date: 2016-05-25
Anticipated expiration: 2036-01-28
Also published as: CN105596226B

Abstract

Disclosed is a more stable and longer-lasting leucoderma covering liquid kit. The kit comprises a first package and a second package. Water-based liquid containing a leucoderma covering active agent is placed in the first package, and water-based liquid containing watersoluble pigment is placed in the second package. Due to the fact that the pigment and the leucoderma covering active agent are placed in the different packages, the reaction between the active matter and the pigment is avoided, and a leucoderma covering composition is stable in property and invariant in color and achieves the effects that covering can be achieved rapidly and coloring is longer-lasting.

Description

A kind of novel leucoderma hides composition cover box

Technical field

The invention belongs to the cosmetic field that leucoderma hides, be specifically related to a kind of novel leucoderma and hide composition coverBox. This leucoderma covering composition has the hickie of covering and beautifies skin function, and it is with respect to existing covering agent, and character is steadyFixed, nondiscolouring, can hide and can painted more lasting effect fast thereby reach.

Background technology

Leucoderma (vitiligo) is a kind of common multiple pigmented dermatosis. This disease takes off with local or general property pigmentLosing and forming hickie is feature, is the common skin diseases of an impact beauty treatment, has easy diagnosis, treats difficult feature. Leucoderma is aliveAll there is generation various places, boundary, and approximately there is ten million people's morbidity in China, and the incidence of disease is about 1%-2%, is one of world's skin disease three large chronic diseases.At present, leukodermic methods for the treatment of is varied, comprising Western medicine therapy, herbal treatment, physical therapy and operative treatmentDeng. But because leucoderma disease is because of complexity, its pathogenesis is not yet completely clear and definite at present, therefore effectively treats leucoderma wind faciesWork as difficulty. Because leukodermic affected part occurs mainly with head, face, neck and limb end, therefore, dressing is difficult to hide the white of patientSpot, this has greatly affected the daily life of patients with vitiligo.

Along with the development of medical cosmetology, people start in cosmetology, leucoderma to be made up or covering treatment, profitWith the hyperchromic effect of some composition, make hickie recover the normal colour of skin. Common external application leucoderma preparation is roughly divided into as follows at presentFour classes: one, the Chinese medicine taking Psoralea corylifolia as representative, this class material contains photosensitization active component, shines after being applied to skin by lightPenetrate and can excite melanin to generate; Two, corticosteroid formulations, corticosteroid hormone preparation can be white to what caused by immune responsePurplish or white patches on the skin wind tells on; Three, beautifying drug, such as mustargen, dihydroxyacetone (DHA) etc.; Four, pigment toner, itself and cosmetic baseForm creme or paste, on hickie, play covering effect thereby be coated in. In this four classes external preparation, traditional Chinese medicine ingredients onsetSlowly, and corticosteroid is as hormone, and long-term use can produce serious side effect. Therefore, can add lustre to fast with skin andThe medicine class external preparation that can not produce apparent side effect becomes the focus that hickie hides. For example, Zhang Qiliang chief editor, " medical science U.S.Rong Xue ", 1996 the 1st edition, 5% dihydroxyacetone (DHA) solution and 15% liquor argenti nitratis ophthalmicus are disclosed, repeat be coated with put on the skin, can make hickie dyeLook. Section sunrise institute etc., " therapy of vitiligo present situation ", " Chengde Medical College's journal ", the 11st the 2nd phase of volume in 1994, discloses dihydroxyAcetone is applied to hickie place, and the effect of itself and horn cell, can produce color and luster, and 5% dihydroxyacetone (DHA) is applied to hickie place, every day repeatedly,Smear continuously, after coating, color can keep 2-3 days. Guo Suizhang, " leucoderma medicine treatment general introduction ", " straits medicine ", 1998The 10th the 3rd phase of volume, (containing dihydroxyacetone (DHA) 2.0, cobalamin 00mg, adds diformazan to disclose 2% dihydroxyacetone (DHA) complex liquidBase sulfoxide 100ml) treatment leucoderma. Li Gang etc., " 5% dihydroxyacetone (DHA) frost external curing leucoderma 46 routine observation of curative effect ", " workThe doctor of enterprise periodical ", the 17th the 2nd phase of volume in 2004, disclose 25g dihydroxyacetone (DHA) has been dissolved in 475g cream base, be formulated as 5% 2Hydroxypropanone-frost.

In the last few years, the patented technology that numerous leucoderma hide, for example Chinese patent application had also been there is both at home and abroad99114078.8 disclose a kind of externally-applied medicinal composition, and its ethanol by mustine hydrochlcride, dihydroxyacetone, Psoralea corylifolia and safflower is carriedGet thing and Laurocapram composition. Treat skin pigment reduction external used medicine 200610137625.8 disclose equally one,It is made up of alcohol, the fleece-flower root, Psoralea corylifolia, the sophora bud, dihydroxyacetone. 201210032196.3 disclosing a kind of leucoderma hidesAgent is Masking sol or covering frost; The chief component of described Masking sol comprises: 1,2-PD, Jojoba ester, anticorrisive agent, tableSurface-active agent, vitamin E acetate, 1,3-Dihydroxyacetone, food coloring and deionized water. 201210303530.4 discloseThere is a deep-sea marine algae extract for leucoderma covering effect, white thereby it utilizes multiple algae to extract to have obtained makingThe active material that spot skin adds lustre to, and the covering composition that comprises this extract. 200410070380.2 disclose oneLeukoderma covering agent, by 1 portion of food coloring, 6-10 part essence, 80-100 dihydroxyacetone (DHA), 30-50 part alcohol, 1500-1800Part water forms.

From current covering product, emulsion-type is due to oily existence, sensuously salubrious not in use, and emulsionVery large problem is to be not easy to smear evenly, can on hickie skin, produce color lump, affects attractive in appearancely, and therefore solution-type hidesLid product is best suited for. And for solution-type product, in order to reach the object that hides immediately and indicate, water colo(u)rTo hide the indispensable composition of product, but because the active material in covering product is to light, heat, humidity, pH value and productIn product, the character of other composition is very sensitive, causes product very unstable, and the most obvious phenomenon is colorability variation, and the 2nd, produceProduct color changes, inconsistent with the normal colour of skin after using, and can not reach the object hiding immediately, and the 3rd, product can produce monsterTaste, makes user be difficult to accept. General liquid-type product will produce obvious color change after preparation completes half a year, companionWith falling sharply of active material, colorability significantly declines. Such result causes product not also to be sold to consumer on hand, producesProduct just may have been crossed the term of validity. Through the inventor's research for many years, find to cause hiding the reason of product variable color, usefulness reductionThat the materials such as the pigment in dihydroxyacetone (DHA) and product react. Therefore, need to develop a kind of stablely, have again immediately and to hideThe product of lid and long-acting covering.

Summary of the invention

In order to overcome the problems referred to above, the inventor finds, Masking sol is separately packed, and dihydroxyacetone (DHA) isoreactivity material is putIn the first packaging, other material such as water colo(u)r is placed in the second packaging, in the time that consumer need to use, then both are mixedClose, can avoid like this reacting of product dihydroxyacetone (DHA) isoreactivity material and pigment, solve the unsettled problem of shelf life, the utmost pointThe earth has improved the term of validity of Masking sol, reaches the function of covering immediately and long-acting covering.

Therefore, an object of the present invention is to provide a kind of novel leucoderma and hide composition cover box, it comprises the first bagDress and the second packaging, first packs interior is the waterborne liquid that hides activating agent containing leucoderma, does not contain pigment, its in this waterborne liquidMiddle leukoderma covering agent accounts for the 3%-10% of Masking sol gross weight, the waterborne liquid for comprising water colo(u)r in the second packaging, itsMiddle water colo(u)r accounts for the 0.05%-0.3% of Masking sol.

Wherein leucoderma covering activating agent is dihydroxyacetone (DHA).

The method preparation that deep-sea marine algae extract is wherein recorded with inventor's granted patent 201210303530.4.

Water colo(u)r be wherein famille rose, amaranth, lemon yellow, sunset yellow, light blue, erythrosine, indigo, light blue,Newly red and composition thereof, the preferably mixture of famille rose, sunset yellow and light blue, its ratio is 2:15:1.

According to leucoderma Masking sol cover box of the present invention, it is characterized in that further comprising in the first and/or second packagingErythrulose, glyceraldehyde, silver nitrate, mustargen, corticosteroid, deep-sea marine algae extract, lawsone, juglone or its mixingThing is as painted reinforcing agent.

According to leucoderma Masking sol cover box of the present invention, it is characterized in that further comprising in the first and/or second packagingNMF, antioxidant, chelating agent, anticorrisive agent, flavouring agent or their combination.

Another object of the present invention is to provide a kind of leukodermic cosmetic method that hides, and is included in leucoderma disease sites and executesWith using Masking sol of the present invention.

Brief description of the drawings

Fig. 1 is the appearance effect figure of reference examples 1;

Fig. 2 is that reference examples 1 normal temperature is placed the design sketch after half a year;

Fig. 3 places the design sketch after 4 weeks at 45 DEG C of reference examples 1 incubators.

Detailed description of the invention

Embodiment 1

Get 5g dihydroxyacetone (DHA) and 45g water and mix and be placed in the first packaging, get 2g alcohol, the water-soluble food coloring of 0.1g and47.9g water mixes and is placed in the second packaging, and the first packaging and the second packaging are put into packing box and obtained cover box of the present invention.

Embodiment 2

Get 3g dihydroxyacetone (DHA) and 47g water and mix and be placed in the first packaging, get 1g alcohol, the water-soluble food coloring of 0.1g and48.9g water mixes and is placed in the second packaging, and the first packaging and the second packaging are put into packing box and obtained cover box of the present invention.

Embodiment 3

Get 10g dihydroxyacetone (DHA) and 40g water and mix and be placed in the first packaging, get 10g alcohol, the water-soluble food coloring of 0.3g and39.7g water mixes and is placed in the second packaging, and the first packaging and the second packaging are put into packing box and obtained cover box of the present invention.

Embodiment 4

Get 8g dihydroxyacetone (DHA) and 42g water and mix and be placed in the first packaging, get 5g alcohol, the water-soluble food coloring of 0.2g and44.8g water mixes and is placed in the second packaging, and the first packaging and the second packaging are put into packing box and obtained cover box of the present invention.

Embodiment 5

Get 6g dihydroxyacetone (DHA) and 44g water and mix and be placed in the first packaging, get the water-soluble food coloring of 0.3g and 49.7g water mixedClose and be placed in the second packaging, the first packaging and the second packaging are put into packing box and obtained cover box of the present invention.

Embodiment 6 leucoderma hide the preparation of composition

Get 7g dihydroxyacetone (DHA) and 43g water and mix and be placed in the first packaging, get the water-soluble food coloring of 0.2g and 49.8g water mixedClose and be placed in the second packaging, the first packaging and the second packaging are put into packing box and obtained cover box of the present invention.

Reference examples 1

Get 5g dihydroxyacetone (DHA), 2g alcohol, 0.1g water colo(u)r and 92.9g water and mix, both obtained leucoderma and hidden activating agent.

Effect example

Activity substance content is measured

1) take 1,2,4,6,8 and 10g dihydroxyacetone (DHA) standard items, be placed in respectively 100ml volumetric flask, molten with 80% acetonitrileLiquid is diluted to scale, has both obtained standard items;

2) chromatographic condition: HILIC chromatographic column (4.6mm × 250mm, 5 μ are m); Mobile phase is acetonitrile: ammonium acetate solution (5mmol/L)=92:8; Flow velocity is 1.0mL/min; Detection wavelength is 272nm; Sample size is 10 μ L;

3) get respectively standard items 10 μ L, inject high performance liquid chromatograph, drawing standard curve, then gets respectively 10 μ L reference examples1, embodiment 1, normal temperature place reference examples 1, normal temperature after half a year and place at 45 DEG C of embodiment 1, incubators after half a year and place 4 weeksAt 45 DEG C of reference examples 1 and incubators, place 4 weeks embodiment 1, inject chromatographic column, calculate containing of dihydroxyacetone (DHA) in each sampleAmount, result is as shown in table 1.

Table 1: dihydroxyacetone (DHA) content

Stability and coloring effect experiment

Use respectively reference examples 1, embodiment 1, normal temperature to place reference examples 1 and the embodiment 1 after half a year, at 45 DEG C of incubators, placeReference examples 1 and the embodiment 1 of 4 weeks dye to hickie, record painted and lasting effect, shown in result table 2:

Table 2: painted and persistence

The above results show, the Masking sol of reference examples 1 and embodiment 1 in the time just preparing, because dihydroxyacetone (DHA) content is suitable,Coloring effect is as broad as long, but is placing after half a year, and it is green that the Masking sol of reference examples 1 has turned, can not be consistent with the colour of skin,Smear color and only within 1 week, just disappear completely, place after 4 weeks for 45 DEG C, reference examples 1 has become green completely, cannot play immediately and hideThe effect of lid, and due to the basic approach exhaustion of dihydroxyacetone (DHA), therefore there is no the coloring effect of dihydroxyacetone (DHA). And embodiment1 Masking sol, places half a year or in incubator, accelerates after experiment, and its appearance color does not have significant change, painted energyPower does not have difference substantially yet, and visible Masking sol of the present invention has significantly improved stability, and keeps Masking sol quick-acting and long-actingCovering effect.

Claims

1. a novel leucoderma covering composition cover box, it comprises the first packaging and the second packaging, is containing white in the first packagingPurplish or white patches on the skin wind hides the waterborne liquid of activating agent, and in this waterborne liquid, containing pigment, wherein leukoderma covering agent accounts for Masking sol gross weight3%-10%, be the waterborne liquid that comprises water and water colo(u)r in the second packaging, and wherein water colo(u)r accounts for Masking sol0.05%-0.3%。

2. hide composition cover box according to the novel leucoderma of claim 1, wherein leucoderma covering activating agent is dihydroxy thirdKetone.

3. hide composition cover box according to the novel leucoderma of claim 1, wherein water colo(u)r is selected from famille rose, three-coloured amaranthRed, lemon yellow, sunset yellow, light blue, erythrosine, indigo, light blue, new red and composition thereof.

4. hide composition cover box according to the novel leucoderma of claim 1, wherein water colo(u)r be famille rose, sunset yellow andThe mixture of light blue, its ratio is 2:15:1.

5. hide composition cover box according to the novel leucoderma of claim 1, it is characterized in that entering in the first and/or second packagingOne step comprises erythrulose, glyceraldehyde, silver nitrate, mustargen, corticosteroid, deep-sea marine algae extract, lawsone, jugloneOr its mixture is as painted reinforcing agent.

6. hide composition cover box according to the novel leucoderma of claim 1, it is characterized in that entering in the first and/or second packagingOne step comprises NMF, antioxidant, chelating agent, anticorrisive agent, flavouring agent or their combination.

Hide a leukodermic cosmetic method, be included in leucoderma disease sites use claim 1-6 leucoderma hideLid composition.