CN105596226B

CN105596226B - Novel vitiligo covering composition kit

Info

Publication number: CN105596226B
Application number: CN201610058875.6A
Authority: CN
Inventors: 胡发刚
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-01-28
Filing date: 2016-01-28
Publication date: 2019-12-24
Anticipated expiration: 2036-01-28
Also published as: CN105596226A

Abstract

A more stable and long-acting vitiligo covering liquid kit comprises a first package and a second package, wherein the first package is filled with aqueous liquid containing vitiligo covering active agents, and the second package is filled with aqueous liquid containing water-soluble pigment. The pigment and the vitiligo covering active agent are placed in different packages, so that the reaction of the active substance and the pigment is avoided, the vitiligo covering composition has stable property and no color change, and the effects of quick covering and more lasting coloring are achieved.

Description

Novel vitiligo covering composition kit

Technical Field

The invention belongs to the field of cosmetics for vitiligo covering, and particularly relates to a novel vitiligo covering composition kit. The vitiligo covering composition has the functions of covering leukoplakia and beautifying skin, and compared with the existing covering agent, the vitiligo covering composition has stable property and no color change, thereby achieving the effects of quick covering and more lasting coloring.

Background

Vitiligo (vitiligo) is a common and frequent pigmentary dermatosis. The disease is characterized by local or generalized depigmentation to form leukoplakia, is a common skin disease affecting beauty treatment, and has the characteristics of easy diagnosis and difficult treatment. Vitiligo occurs all over the world, about ten million people in China have diseases, the morbidity is about 1% -2%, and the vitiligo is one of three persistent ailments of world skin diseases. At present, the treatment methods of vitiligo are various, and the treatment methods comprise western medicine therapy, traditional Chinese medicine therapy, physical therapy, operation therapy and the like. However, since the pathogenesis of vitiligo is not completely understood at present due to its complexity, it is very difficult to effectively treat vitiligo. The affected part of the leucoderma appears on the head, the face, the neck and the tail ends of the four limbs, so the dressing is difficult to cover the leukoplakia of the patient, which greatly influences the daily life of the leucoderma patient.

With the development of medical cosmetology, people begin to make up or cover leucoderma cosmetically, and make use of the hyperchromic effect of certain components to restore leucoderma to normal skin color. The currently common external vitiligo preparations are roughly divided into four types: firstly, the traditional Chinese medicine represented by fructus psoraleae contains photosensitization active ingredients, and melanin can be excited to generate by irradiation of light after the traditional Chinese medicine is applied to the skin; secondly, a corticosteroid preparation, wherein the corticosteroid hormone preparation can produce an effect on leucoderma caused by immune response; thirdly, cosmetic drugs such as nitrogen mustard, dihydroxyacetone, etc.; and fourthly, pigment toner which forms cream or ointment together with the cosmetic matrix and is coated on the white spots so as to play a role in covering. Of the four types of external preparations, the Chinese medicinal ingredients have slow onset of action, and corticosteroids, as hormones, have serious side effects after long-term use. Therefore, pharmaceutical external preparations capable of rapidly developing color with the skin without causing significant side effects are hot spots for white spot coverage. For example, Zhang Qin Ministry, medical cosmetology, 1996 edition 1, discloses staining of white spots by repeated application of 5% dihydroxyacetone solution and 15% silver nitrate solution. Sungxin, et al, "Current State of treatment of vitiligo", journal of the institute of medical science, 1994 Vol.11, No. 2, disclose that dihydroxyacetone is applied to the vitiligo to produce color and luster by the action of the dihydroxyacetone on the keratinocyte, 5% of dihydroxyacetone is applied to the vitiligo and is continuously applied several times a day, and the color can be maintained for 2-3 days after application. Guo Chao, "an outline of the treatment of vitiligo", Haixian medicine, 1998, Vol.10, No. 3, discloses a 2% dihydroxyacetone complex solution (containing dihydroxyacetone 2.0, vitamin B1200 mg, added with 100ml of dimethyl sulfoxide) for treating vitiligo. Legang et al, "46 cases of external cream containing 5% dihydroxyacetone for treating vitiligo observed in curative effect", journal of industry and enterprise, 2004, Vol.17, No. 2, disclose that 25g dihydroxyacetone is dissolved in 475g cream base to prepare 5% dihydroxyacetone cream.

In recent years, numerous vitiligo covering patent technologies have appeared at home and abroad, for example, Chinese patent application 99114078.8 discloses an external pharmaceutical composition, which consists of mechlorethamine hydrochloride, dihydroxyacetone, ethanol extracts of fructus psoraleae and safflower and laurocapram. 200610137625.8A topical medicine for the treatment of skin hypopigmentation is prepared from ethanol, radix Polygoni Multiflori, fructus Psoraleae, flos Sophorae Immaturus, and dihydroxyacetone. 201210032196.3 discloses a vitiligo covering agent, which is a covering liquid or a covering cream; the covering liquid mainly comprises the following components: 1, 2-propylene glycol, jojoba ester, antiseptic, surfactant, vitamin E acetate, 1, 3-dihydroxyacetone, edible pigment and deionized water. 201210303530.4 discloses a deep sea algae extract with vitiligo covering effect, which is extracted from various algae to obtain active substances capable of coloring vitiligo skin, and a covering composition containing the extract. 200410070380.2 discloses a vitiligo covering agent, which is composed of 1 part of edible pigment, 6-10 parts of essence, 80-100 parts of dihydroxyacetone, 30-50 parts of alcohol and 1500-1800 parts of water.

From the prior covering products, the emulsion type is not refreshing enough in use feeling due to the existence of oil, and the emulsion has the great problem that the emulsion is not easy to be evenly smeared, can generate color blocks on white spot skin and influence the beauty, so the solution type covering product is most suitable. For solution type products, the water-soluble pigment is an indispensable component for covering the products for the purpose of immediate covering and indication, but the active substance in the covering product is sensitive to light, heat, moisture, pH value and other components in the product, so that the products are very unstable, the most obvious phenomenon is that the coloring capability is deteriorated, secondly, the color of the products is changed, the products are inconsistent with the normal skin color after use, and the purpose of immediate covering cannot be achieved, thirdly, the products generate strange taste, so that the products are difficult to accept by users. Generally, liquid products undergo a significant colour change after half a year of formulation, with a marked reduction in the colouring capacity accompanied by a sharp decrease in the active substance. This results in a product that has not been sold to the consumer and may have passed the expiration date. After years of research by the inventor, the reason that the coloring of the covering product and the reduction of the efficacy are caused by the reaction of dihydroxyacetone and substances such as pigments in the product is found. Therefore, there is a need to develop a product that is stable, yet has both immediate and long-lasting coverage.

Disclosure of Invention

In order to overcome the problems, the inventor finds that the covering liquid is packaged separately, active substances such as dihydroxyacetone and the like are placed in the first package, other substances such as water-soluble pigments and the like are placed in the second package, and when a consumer needs to use the covering liquid, the active substances and the pigments are mixed, so that the reaction of the active substances such as the dihydroxyacetone and the like and the pigments can be avoided, the problem of unstable shelf life is solved, the effective period of the covering liquid is greatly improved, and the functions of immediate covering and long-acting covering are achieved.

It is therefore an object of the present invention to provide a novel vitiligo covering composition kit comprising a first package containing an aqueous liquid comprising a vitiligo covering active agent, the aqueous liquid being free of pigments, wherein the vitiligo covering active agent comprises from 3% to 10% by weight of the total covering liquid, and a second package containing an aqueous liquid comprising a water soluble pigment, wherein the water soluble pigment comprises from 0.05% to 0.3% of the covering liquid.

Wherein the vitiligo covering active agent is dihydroxyacetone.

Wherein the extract of deep sea algae is prepared by the method described in patent 201210303530.4 granted by the present inventors.

Wherein the water-soluble pigment is carmine, amaranth, lemon yellow, sunset yellow, brilliant blue, erythrosine, indigo, brilliant blue, new red and their mixture, preferably carmine, sunset yellow and brilliant blue mixture, and its ratio is 2: 15: 1.

the vitiligo covering fluid kit according to the present invention is characterized in that the first and/or second pack further comprises erythrulose, glyceraldehyde, silver nitrate, nitrogen mustard, a corticosteroid, a deep sea seaweed extract, lawsone, juglone or a mixture thereof as a coloration enhancer.

The vitiligo covering fluid kit according to the present invention is characterized in that the first and/or second pack further comprises a moisturizer, an antioxidant, a chelating agent, a preservative, a fragrance or a combination thereof.

Another object of the present invention is to provide a cosmetic method for covering vitiligo, which comprises applying the covering liquid of the present invention to the affected part of vitiligo.

Drawings

FIG. 1 is a view showing the appearance of comparative example 1;

FIG. 2 is a graph showing the effect of comparative example 1 after standing at room temperature for half a year;

FIG. 3 is a graph showing the effect of comparative example 1 after it was left in an incubator at 45 ℃ for 4 weeks.

Detailed Description

Example 1

Mixing 5g of dihydroxyacetone and 45g of water, placing the mixture into a first package, mixing 2g of alcohol, 0.1g of water-soluble food pigment and 47.9g of water, placing the mixture into a second package, and placing the first package and the second package into a packaging box to obtain the kit.

Example 2

3g of dihydroxyacetone and 47g of water are mixed and then placed in a first package, 1g of alcohol, 0.1g of water-soluble food pigment and 48.9g of water are mixed and then placed in a second package, and the first package and the second package are placed in a packaging box to obtain the kit.

Example 3

Mixing 10g of dihydroxyacetone and 40g of water, placing the mixture into a first package, mixing 10g of alcohol, 0.3g of water-soluble food pigment and 39.7g of water, placing the mixture into a second package, and placing the first package and the second package into a packaging box to obtain the kit.

Example 4

Mixing 8g of dihydroxyacetone and 42g of water, placing the mixture into a first package, mixing 5g of alcohol, 0.2g of water-soluble food pigment and 44.8g of water, placing the mixture into a second package, and placing the first package and the second package into a packaging box to obtain the kit.

Example 5

6g of dihydroxyacetone and 44g of water are mixed and then placed in a first package, 0.3g of water-soluble food pigment and 49.7g of water are mixed and then placed in a second package, and the first package and the second package are placed in a packaging box to obtain the kit.

EXAMPLE 6 preparation of a composition for vitiligo covering

Mixing 7g of dihydroxyacetone and 43g of water, placing the mixture into a first package, mixing 0.2g of water-soluble edible pigment and 49.8g of water, placing the mixture into a second package, and placing the first package and the second package into a packaging box to obtain the kit.

Comparative example 1

Mixing 5g dihydroxyacetone, 2g alcohol, 0.1g water-soluble pigment and 92.9g water to obtain the vitiligo covering active agent.

Examples of effects

Determination of active substance content

1) Weighing 1, 2, 4, 6, 8 and 10g dihydroxyacetone standard substances, respectively placing the weighed substances into a volumetric flask of 100ml, and diluting the weighed substances to a scale by using an acetonitrile solution of 80 percent to obtain the standard substance;

2) chromatographic conditions are as follows: HILIC column (4.6 mm. times.250 mm, 5 μm); the mobile phase is acetonitrile: ammonium acetate solution (5 mmol/L) = 92: 8; the flow rate is 1.0 mL/min; the detection wavelength is 272 nm; the sample injection amount is 10 mu L;

3) after 10. mu.L of each standard sample was taken and injected into a high performance liquid chromatograph to draw a standard curve, 10. mu.L of each of comparative example 1 and example 1, comparative example 1 after half a year of standing at room temperature, comparative example 1 after 4 weeks of standing at 45 ℃ in an incubator, and example 1 after 4 weeks of standing at 45 ℃ in an incubator were taken and injected into a chromatographic column to calculate the content of dihydroxyacetone in each sample, and the results are shown in Table 1.

Table 1: dihydroxyacetone content

Stability and coloring Effect test

The results of staining white spots using control 1, example 1, control 1 and example 1 after half a year at room temperature, and control 1 and example 1 after 4 weeks at 45 ℃ in an incubator, respectively, are shown in table 2:

table 2: coloring and durability

The above results show that the masking liquids of comparative example 1 and example 1 did not have different coloring effects immediately after preparation due to the equivalent content of dihydroxyacetone, but the masking liquid of comparative example 1 turned green after half a year of storage and could not be kept consistent with skin color, and the applied color completely disappeared only for 1 week, and after 4 weeks of storage at 45 ℃, comparative example 1 turned green completely, and could not immediately cover, and further, the coloring effect of dihydroxyacetone was not exhibited because the dihydroxyacetone was almost completely consumed. However, the covering liquid of example 1, after being placed for half a year or being subjected to an accelerated test in a heat preservation box, has no obvious change in appearance color and basically no difference in coloring ability, and thus, the covering liquid of the present invention has significantly improved stability and maintains quick-acting and long-acting covering effect.

Claims

1. A novel vitiligo covering composition kit comprising a first package comprising an aqueous liquid comprising a vitiligo covering active agent, the aqueous liquid being free of pigments, wherein the vitiligo covering active agent comprises from 3% to 10% by weight of the total vitiligo covering composition, and a second package comprising an aqueous liquid comprising water and a water soluble pigment, wherein the water soluble pigment comprises from 0.05% to 0.3% by weight of the vitiligo covering composition, wherein the vitiligo covering active agent is dihydroxyacetone, wherein the water soluble pigment is a mixture of carmine, sunset yellow and brilliant blue.

2. The novel vitiligo covering composition kit according to claim 1, wherein the carmine, sunset yellow and brilliant blue are in a ratio of 2: 15: 1.

3. The new vitiligo covering composition kit according to claim 1, characterized in that the first and/or second package further comprises erythrulose, glyceraldehyde, a deep sea seaweed extract, or a mixture thereof as a coloration enhancer.

4. The new vitiligo covering composition kit according to claim 1, characterized in that the first and/or second package further comprises a moisturizer, an antioxidant, a chelating agent, a preservative, a fragrance or a combination thereof.

5. A cosmetic method for covering vitiligo comprising applying the vitiligo covering composition according to claims 1-4 to the affected part of vitiligo.