CN105661504A - Production method of lozenge of grape skin and seed extract rich in resveratrol - Google Patents
Production method of lozenge of grape skin and seed extract rich in resveratrol Download PDFInfo
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- CN105661504A CN105661504A CN201610022823.3A CN201610022823A CN105661504A CN 105661504 A CN105661504 A CN 105661504A CN 201610022823 A CN201610022823 A CN 201610022823A CN 105661504 A CN105661504 A CN 105661504A
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- Prior art keywords
- resveratrol
- seed extract
- vitis viniferae
- pericarpium vitis
- lozenge
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Links
- 235000021283 resveratrol Nutrition 0.000 title claims abstract description 36
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 title claims abstract description 35
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 title claims abstract description 35
- 229940016667 resveratrol Drugs 0.000 title claims abstract description 35
- 239000000284 extract Substances 0.000 title claims abstract description 31
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 4
- 235000014787 Vitis vinifera Nutrition 0.000 title abstract description 10
- 235000009754 Vitis X bourquina Nutrition 0.000 title abstract 8
- 235000012333 Vitis X labruscana Nutrition 0.000 title abstract 8
- 239000007937 lozenge Substances 0.000 title abstract 5
- 240000006365 Vitis vinifera Species 0.000 title description 3
- 241000219095 Vitis Species 0.000 claims abstract description 36
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 15
- 238000000034 method Methods 0.000 claims abstract description 12
- 239000000843 powder Substances 0.000 claims abstract description 11
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 8
- 244000045195 Cicer arietinum Species 0.000 claims abstract description 8
- 235000010523 Cicer arietinum Nutrition 0.000 claims abstract description 8
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 8
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims abstract description 8
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims abstract description 8
- 235000010447 xylitol Nutrition 0.000 claims abstract description 8
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims abstract description 8
- 229960002675 xylitol Drugs 0.000 claims abstract description 8
- 239000000811 xylitol Substances 0.000 claims abstract description 8
- 239000004375 Dextrin Substances 0.000 claims abstract description 7
- 229920001353 Dextrin Polymers 0.000 claims abstract description 7
- 235000019425 dextrin Nutrition 0.000 claims abstract description 7
- 235000009392 Vitis Nutrition 0.000 claims description 29
- 229940046011 buccal tablet Drugs 0.000 claims description 19
- 239000006189 buccal tablet Substances 0.000 claims description 19
- 241000219112 Cucumis Species 0.000 claims description 7
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 claims description 7
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 claims description 7
- 235000014101 wine Nutrition 0.000 claims description 6
- 241000219094 Vitaceae Species 0.000 claims description 2
- 230000001413 cellular effect Effects 0.000 claims description 2
- 230000006837 decompression Effects 0.000 claims description 2
- 230000018044 dehydration Effects 0.000 claims description 2
- 238000006297 dehydration reaction Methods 0.000 claims description 2
- 238000004821 distillation Methods 0.000 claims description 2
- 235000021021 grapes Nutrition 0.000 claims description 2
- 239000004615 ingredient Substances 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 238000000926 separation method Methods 0.000 claims description 2
- 238000000748 compression moulding Methods 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 abstract description 6
- 239000002994 raw material Substances 0.000 abstract description 5
- 150000001875 compounds Chemical class 0.000 abstract description 4
- 238000000605 extraction Methods 0.000 abstract description 3
- 230000004071 biological effect Effects 0.000 abstract description 2
- 239000000796 flavoring agent Substances 0.000 abstract description 2
- 235000019634 flavors Nutrition 0.000 abstract description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 abstract 1
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 1
- 241000219118 Cucumis melo var. cantalupo Species 0.000 abstract 1
- 229940116229 borneol Drugs 0.000 abstract 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 1
- 235000013312 flour Nutrition 0.000 abstract 1
- 210000000936 intestine Anatomy 0.000 abstract 1
- 229940041616 menthol Drugs 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000002604 ultrasonography Methods 0.000 abstract 1
- HSTZMXCBWJGKHG-UHFFFAOYSA-N (E)-piceid Natural products OC1C(O)C(O)C(CO)OC1OC1=CC(O)=CC(C=CC=2C=CC(O)=CC=2)=C1 HSTZMXCBWJGKHG-UHFFFAOYSA-N 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 229960003764 polydatin Drugs 0.000 description 5
- HSTZMXCBWJGKHG-CUYWLFDKSA-N trans-piceid Polymers O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=CC(\C=C\C=2C=CC(O)=CC=2)=C1 HSTZMXCBWJGKHG-CUYWLFDKSA-N 0.000 description 5
- 230000000968 intestinal effect Effects 0.000 description 4
- 238000003825 pressing Methods 0.000 description 4
- XFZJEEAOWLFHDH-UHFFFAOYSA-N (2R,2'R,3R,3'R,4R)-3,3',4',5,7-Pentahydroxyflavan(48)-3,3',4',5,7-pentahydroxyflavan Natural products C=12OC(C=3C=C(O)C(O)=CC=3)C(O)CC2=C(O)C=C(O)C=1C(C1=C(O)C=C(O)C=C1O1)C(O)C1C1=CC=C(O)C(O)=C1 XFZJEEAOWLFHDH-UHFFFAOYSA-N 0.000 description 3
- 208000024172 Cardiovascular disease Diseases 0.000 description 3
- CWEZAWNPTYBADX-UHFFFAOYSA-N Procyanidin Natural products OC1C(OC2C(O)C(Oc3c2c(O)cc(O)c3C4C(O)C(Oc5cc(O)cc(O)c45)c6ccc(O)c(O)c6)c7ccc(O)c(O)c7)c8c(O)cc(O)cc8OC1c9ccc(O)c(O)c9 CWEZAWNPTYBADX-UHFFFAOYSA-N 0.000 description 3
- MOJZMWJRUKIQGL-FWCKPOPSSA-N Procyanidin C2 Natural products O[C@@H]1[C@@H](c2cc(O)c(O)cc2)Oc2c([C@H]3[C@H](O)[C@@H](c4cc(O)c(O)cc4)Oc4c3c(O)cc(O)c4)c(O)cc(O)c2[C@@H]1c1c(O)cc(O)c2c1O[C@@H]([C@H](O)C2)c1cc(O)c(O)cc1 MOJZMWJRUKIQGL-FWCKPOPSSA-N 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- HGVVOUNEGQIPMS-UHFFFAOYSA-N procyanidin Chemical compound O1C2=CC(O)=CC(O)=C2C(O)C(O)C1(C=1C=C(O)C(O)=CC=1)OC1CC2=C(O)C=C(O)C=C2OC1C1=CC=C(O)C(O)=C1 HGVVOUNEGQIPMS-UHFFFAOYSA-N 0.000 description 3
- 229920002414 procyanidin Polymers 0.000 description 3
- 235000020095 red wine Nutrition 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- 206010068319 Oropharyngeal pain Diseases 0.000 description 2
- 201000007100 Pharyngitis Diseases 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000002526 effect on cardiovascular system Effects 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 235000002532 grape seed extract Nutrition 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000010282 Emodin Substances 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 208000035150 Hypercholesterolemia Diseases 0.000 description 1
- 244000124853 Perilla frutescens Species 0.000 description 1
- 235000004348 Perilla frutescens Nutrition 0.000 description 1
- 240000001341 Reynoutria japonica Species 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- TWOWSRSKGJSZHZ-VRHDFFKNSA-N bouvardin Chemical compound C1=CC(OC)=CC=C1C[C@H](N(C)C(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](N(C1=O)C)C2)C(=O)N[C@@H](C)C(=O)N(C)[C@H]1[C@@H](O)C(C=C1)=CC=C1OC1=CC2=CC=C1O TWOWSRSKGJSZHZ-VRHDFFKNSA-N 0.000 description 1
- BNOCDYMCAVSRBT-UHFFFAOYSA-N bouvardin Natural products COc1ccc(CC2N(C)C(=O)C(C)NC(=O)C(C)NC(=O)C3Cc4ccc(O)c(Oc5cccc(c5)C(O)C(N(C)C(=O)C(C)NC2=O)C(=O)N3C)c4)cc1 BNOCDYMCAVSRBT-UHFFFAOYSA-N 0.000 description 1
- 108010047824 bouvardin Proteins 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 231100000517 death Toxicity 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000007938 effervescent tablet Substances 0.000 description 1
- RHMXXJGYXNZAPX-UHFFFAOYSA-N emodin Chemical compound C1=C(O)C=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O RHMXXJGYXNZAPX-UHFFFAOYSA-N 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 230000031891 intestinal absorption Effects 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000003828 vacuum filtration Methods 0.000 description 1
- 238000011514 vinification Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A production method uses high-quality fresh grape skins and seeds as raw materials, ultrasound wall broken technology, and ethanol as an extraction solvent to extract grape skin and seed extracts rich in resveratrol from the grape skins and seeds. According to the resveratrol absorption characteristics in the human body, an orally administrated lozenge rich in resveratrol is developed. Grape skin and seed extract powder, dextrin, xylitol, chickpea refine flour, menthol, natural cucumis melo var. saccharinus flavor and borneol are used as raw materials and the raw materials are pressed and prepared into a mouth lozenge for cardio-cerebral vessel health care, and the lozenge overcomes the difficult problem of human intestines for the absorption of the resveratrol. The temperature in the whole processes of the grape skin and seed extract preparation does not exceed 50 DEG C, so that the biological activities of resveratrol and other compounds thereof in the grape skin and seed extracts are kept. The grape skin and seed extract lozenge is slow in dissolution once entering mouth, conductive for human body absorption, delicate fragrant and conductive for throats, and a functional health-care products convenient in carrying and use.
Description
Technical field
The present invention relates to biological health-care product field, particularly to a kind of method that Pericarpium Vitis viniferae, seed extract produce buccal tablet.
Background technology
Nineteen nineties American scholar finds, containing abundant resveratrol Recveratrol in wine, to be called for short Rec, therefore widened resveratrol and there is a possibility that in various plants. In the past, people are more extraction resveratrols from plant polygonum cuspidatum, therefore, Rhizoma Polygoni Cuspidati price rising all the way, residue in Fructus Vitis viniferae alcoholic process, it it is that vine is in order to prevent mycete from invading containing a certain amount of resveratrol, polydatin and procyanidin, resveratrol or polydatin, it is prevented that the bouvardin that mattae rots and produces. Wherein in wine making process, skin, seed are not fully obtained by, procyanidin major part in Pericarpium Vitis viniferae has been dissolved in water or lightwater moderator wine, but it is water insoluble and be insoluble in the multiple compounds such as resveratrol or polydatin of low-concentration ethanol still to have some in Pericarpium Vitis viniferae. Research finds, life-saving, anticancer, anti-cardiovascular disease are had special effect by resveratrol, therefore, have opened Frenchman's often edible beefsteak, the non-health food of the hypercholesterolemias such as chips, but the sickness rate of cardiovascular diseases only have the U.S. 13 reason. Resveratrol in wine and their alcohol drinking patterns are all to the important effect suppressing cardiovascular disease to play. From Fructus Vitis viniferae, extract resveratrol be absent from the toxicity problem of rheum emodin, at present, it does not have find the report that there are harmful components in Fructus Vitis viniferae extract. The relevant annual cardiovascular deaths of actuarial prediction China is approximately 300,000, and therefore, recent domestic biosphere occurs in that the upsurge extracting procyanidin and resveratrol and polydatin from Fructus Vitis viniferae residue. Polydatin is in human saliva and intestinal, under the effect of enzyme, resveratrol can be changed into, wherein also having the multiple compound that human body is useful, conventional technology is generally extracted one of which active substance and is abandoned other beneficiating ingredient, actually the extraction of single component, method is numerous and diverse, efficiency is low, and cost is high, and modern Chinese medicine has clearly recognized that the collaborative addition effect of the multiple beneficial material of biological natural perfect combination is advantageously in the health of people.
Resveratrol content in Pericarpium Vitis viniferae reaches as high as 50-100mg/Kg, this kind with Fructus Vitis viniferae has great relation, wherein in Pinot Noir Pericarpium Vitis viniferae, the content of resveratrol is the highest, next to that U.S. happy Cabernet Sauvignon, additionally in close relations with weather and air humidity, the particularly cool, damp when vintage, the Resveratrol content in Pericarpium Vitis viniferae is higher, because such weather conditions are conducive to mycete to infect, vine will produce more resveratrol to safeguard the reason of plant health.
Research finds, human body can be produced more beneficial effect by resveratrol, but water-fast character under resveratrol room temperature, and human body intestinal canal is extremely low to the absorbance of resveratrol, this is because resveratrol in intestinal easily attached by metal ion, it is difficult to enter blood circulation. Someone have studied and French drinks custom vinous, it has been found that it is the custom allowing red wine stop a moment in jaw that Frenchman drinks wine, while enjoying red wine flavour to the full, it is not intended to the resveratrol absorbed in red wine of knowledge. It is more efficient that someone studies discovery oral mucosal absorption, it was found that the efficiency of oral cavity lower jaw Surface absorption resveratrol, to exceed hundreds times than intestinal absorption. According to retrieval, current domestic Pericarpium Vitis viniferae, seed extract application technology, except drinks, mostly generally be capsule, microcapsule, effervescent tablet etc., these products are not ideal for the assimilation effect of resveratrol.
Summary of the invention
The present invention, with the fresh Pericarpium Vitis viniferae of high-quality, seed for raw material, adopts supersonic wave wall breaking technology, with ethanol for extractant, therefrom extracts the extract rich in resveratrol. According to the feature that resveratrol absorbs in human body, develop a kind of rich in the Pericarpium Vitis viniferae of resveratrol, seed extract oral buccal tablet, this buccal tablet is made a kind of health promoting product for cardiovascular and cerebrovascular vessel by extract powder, dextrin, xylitol, chickpea fine powder, Mentholum, natural Hami melon essence, Borneolum Syntheticum mold pressing, overcomes the problem that resveratrol is absorbed difficulty by human body intestinal canal. The whole process temperature that Pericarpium Vitis viniferae, seed extract are produced is less than 50 DEG C, maintain the biological activity of resveratrol and other compound in Pericarpium Vitis viniferae, seed extract, the Pericarpium Vitis viniferae of the present invention, seed extract buccal tablet, entrance dissolves slowly, be conducive to absorption of human body, buccal tablet delicate fragrance sore-throat relieving, is a kind of carrying and functional health goods easy to use.
In order to realize the purpose of the present invention, select the squeezing of Xinjiang high-quality grapes or the fresh residue after wine brewing is scrubbed, centrifuge dehydration, drying, Pericarpium Vitis viniferae, seed are pulverized, adopt high concentration edible ethanol to extract in extracting still, and coordinate intensified by ultrasonic wave breaking cellular wall, then realize solid-liquid separation through vacuum filtration method, again by extracting solution decompression distillation, reclaiming ethanol, concentrated solution adopts boulton process to dry, pulverize into powder. Extract produces overall process temperature less than 50 DEG C, finally adds adjuvant and is processed into buccal tablet.
The raw material weight component of buccal tablet of the present invention is: Pericarpium Vitis viniferae, seed extract 10-30 part, chickpea fine powder 20-40 part, DEXTRIN-45 parts, xylitol 0.5-4 part, Mentholum 0.5-1 part, natural Hami melon essence 0.5-2 part, Borneolum Syntheticum 0.02-0.05 part. fully mix thoroughly, it is molded into diameter 10-18mm, the buccal tablet of thickness 2-5mm.
Specific implementation method
Example 1 present invention is the powder mix homogeneously that will extract in several Pericarpium Vitis viniferaes, as the primary healthcare composition of buccal tablet. Take Pericarpium Vitis viniferae, seed extract 15 parts, chickpea fine powder 37 parts, 45 parts of dextrin, xylitol 2 parts by weight, Mentholum 0.5 part, natural Hami melon essence 0.5 part, Borneolum Syntheticum 0.03 part, abundant uniform mixing, adopts mold pressing pelleter to make diameter 12mm, the buccal tablet of thickness 2mm.
Example 2 is same as Example 1, takes Pericarpium Vitis viniferae, seed extract 20 parts, chickpea fine powder 35 parts, DEXTRIN part by weight, xylitol 3 parts, Mentholum 1 part, natural Hami melon essence 1 part, Borneolum Syntheticum 0.05 part, abundant uniform mixing, adopts mold pressing pelleter to make diameter 16mm, the buccal tablet of thickness 3.5mm.
Example 3 weighs Pericarpium Vitis viniferae, seed extract 30 parts, chickpea fine powder 22 parts, DEXTRIN part, xylitol 4 parts by weight, Mentholum 1 part, natural Hami melon essence 2 parts, Borneolum Syntheticum 0.05 part, abundant uniform mixing, adopts mold pressing pelleter to make diameter 18mm, the buccal tablet of thickness 4mm.
The present invention, through more than 50 years old 7 experts and scholars and 8 development persons object on probation of conduct voluntarily, through 3 months try out, unanimously thinks, this buccal tablet pure taste, entrance dissolves slowly, and delicate fragrance sore-throat relieving, without any untoward reaction, work efficiency significantly improves. 3 example Pericarpium Vitis viniferaes that the present invention enumerates, seed extract buccal tablet are only 3 kinds of formula of series of products, and any simple data point reuse is still within protection scope of the present invention.
Claims (4)
1. the Pericarpium Vitis viniferae rich in resveratrol, the production method of seed extract buccal tablet, it is characterized in that selecting Xinjiang high-quality grapes squeezing or the fresh residue after wine brewing scrubbed, centrifuge dehydration, dry, by Pericarpium Vitis viniferae, seed is pulverized, high concentration edible ethanol is adopted to extract in extracting still, and coordinate intensified by ultrasonic wave breaking cellular wall, it is then passed through vacuum solid-liquid separation, decompression distillation, reclaim ethanol, finally boulton process is adopted to dry concentrated solution, pulverize, obtain extract powder, should rich in the Pericarpium Vitis viniferae of resveratrol, seed extract buccal tablet, it is characterized in that Pericarpium Vitis viniferae, seed extract, chickpea fine powder, dextrin, xylitol, Mentholum, natural Hami melon essence, Borneolum Syntheticum is fully mixed thoroughly, compression molding.
2. Pericarpium Vitis viniferae according to claim 1, seed extract, dry overall process temperature requirement less than 50 degree.
3. according to recipe ingredient in buccal tablet described in claim 1 it is; Pericarpium Vitis viniferae, seed extract consumption are 10-30, and chickpea consumption is 20-40, dextrin consumption 40-45, the xylitol amount of having 0.5-4, Mentholum consumption 0.5-1, Hami melon essence consumption 0.5-2, Borneolum Syntheticum consumption 0.02-0.05.
4. require that the buccal tablet specification described in 3 is; Diameter 10-18mm, thickness 2-5mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610022823.3A CN105661504A (en) | 2016-01-14 | 2016-01-14 | Production method of lozenge of grape skin and seed extract rich in resveratrol |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610022823.3A CN105661504A (en) | 2016-01-14 | 2016-01-14 | Production method of lozenge of grape skin and seed extract rich in resveratrol |
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| CN105661504A true CN105661504A (en) | 2016-06-15 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106260381A (en) * | 2016-08-29 | 2017-01-04 | 益科路博（天津）科技有限公司 | A kind of resveratrol pressed candy of applicable diabetes patient and preparation method thereof |
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- 2016-01-14 CN CN201610022823.3A patent/CN105661504A/en active Pending
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|---|---|---|---|---|
| CN101348805A (en) * | 2007-07-20 | 2009-01-21 | 上海诺德生物实业有限公司 | Process for extracting resveratrol from plant |
| CN101913995A (en) * | 2010-08-10 | 2010-12-15 | 张波 | Method for extracting resveratrol from grape leaves |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106260381A (en) * | 2016-08-29 | 2017-01-04 | 益科路博（天津）科技有限公司 | A kind of resveratrol pressed candy of applicable diabetes patient and preparation method thereof |
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