CN105641548A - Medicine composition for preventing, treating and purifying porcine reproductive and respiratory syndrome and preparing method and application thereof - Google Patents
Medicine composition for preventing, treating and purifying porcine reproductive and respiratory syndrome and preparing method and application thereof Download PDFInfo
- Publication number
- CN105641548A CN105641548A CN201610042736.4A CN201610042736A CN105641548A CN 105641548 A CN105641548 A CN 105641548A CN 201610042736 A CN201610042736 A CN 201610042736A CN 105641548 A CN105641548 A CN 105641548A
- Authority
- CN
- China
- Prior art keywords
- parts
- treating
- preventing
- pharmaceutical composition
- ear disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a medicine composition for preventing, treating and purifying a porcine reproductive and respiratory syndrome. The medicine composition is prepared from, by weight, 4-10 parts of acetylisovaleryltylosin, 15-20 parts of sodium sulfamonomethoxine or doxycycline hydrochloride, 2-6 parts of trimethoxypyrimidine (TMP) or suldimethoxine (DVD), 5-15 parts of coix seeds, 5-15 parts of poria cocos, 1-5 parts of fructooligosaccharide, 20-30 parts of oral glucosum anhydricum and 18-24 parts of auxiliary materials. The invention further discloses a preparing method and application of the medicine composition. All the bulk drugs supplement one another and have functions of clearing heat, eliminating toxin, resisting bacteria and inflammation, protecting intestinal good bacteria and improving organism immunity, and the effect of preventing, treating and purifying the porcine reproductive and respiratory syndrome is remarkable.
Description
Technical field
The present invention relates to veterinary drug technical field, particularly relate to a kind of preventing and treating and purify the pharmaceutical composition of pig blue-ear disease, preparation method and application thereof.
Background technology
Pig blue-ear disease is also known as pig breeding and respiratory disorder syndrome, be by pig breeding and respiratory disorder syndrome virus infection cause a kind of be principal character with sow breeding difficulty, each age in days porcine respiratory disease contagious disease, especially fall ill more serious with farrowing sow and piglet. Pig blue-ear disease is one of Important Infectious Diseases of current serious threat world pig industry development, and this disease infection scope is wide: the pig of various kinds, all ages and classes and purposes all can infect; Route of transmission is how: include respiratory tract, air borne, contact transmission, seminal fluid propagation and vertical transmission! Infect the swinery Sow abortion rate of this disease up to more than 30%, Infection in Piglets sickness rate up to 100%, mortality rate is up to more than 60%. Infect this normal easily mixed infection or secondary infection other virus, antibacterial, parasitic disease after being ill, cause that mortality rate raises further, the economic loss caused is quite serious: the loss that the U.S. causes because of pig blue-ear disease every year reaches more than 600,000,000 dollars, also has the trend increased year by year.
Pig blue-ear disease is immunosuppressive disease, after this viral infection swinery, mainly encroaches on macrophage, macrophage is made to lose phagocytosis pathogen and the ability promoting body injury to repair, seriously damage body's immunity, cause immunosuppressant, cause immunne response decline, slow or failed.
Currently for the prevention of pig blue-ear disease, most employing vaccine immunities, but due to a variety of causes, still fall ill in the pig farm after immunity every year. After morbidity, pig farm manager generally impatiently abuses medicine, mixing treatment is carried out frequently with multi-medicaments such as antiviral agents, antibiotic, interferon, both the mechanism of action being left out medicine is also left out the compatibility principle of medicine, the result is just the contrary, not only toxic and side effects is big, and abuse of antibiotics upsets the beneficial microbe colony suffering from carcass, make body digestive functional disturbance, immunologic function degression, the various virus of secondary, antibacterial, parasitic disease, sb.'s illness took a turn for the worse in acceleration, increases treatment difficulty, and mortality rate increases further.And existing Chinese herbal and crude drugs preparations, though effect has, but therapeutic equivalence is slow, and cure rate is low, and after drug withdrawal, relapse rate is high.
Application number be 201310391181.0 Chinese invention patent disclose a kind of compositions for treating respiratory tract infection of pigs, including following raw material: tartaric acid safe ten thousand rhzomorphs, sulfamonomethoxine sodium, trimethoprim, anhydrous glucose. Although common porcine respiratory disease is all had therapeutic effect by the pharmaceutical composition of above-mentioned patent disclosure, it is also possible to reduce the drug resistance probability of cause of disease, but there is no toxin expelling, protection intestinal beneficial flora and improve the effect of body's immunity, therefore, be further improved.
Summary of the invention
Problem to be solved by this invention is to provide a kind of preventing and treating and purifies the pharmaceutical composition of pig blue-ear disease, preparation method and application; adopt this pharmaceutical composition notable for preventing and treating and purify pig blue-ear disease effect; not easily recur; intestinal beneficial microbes flora can be protected simultaneously, improve immunity of organisms, hence it is evident that release the condition of immune suppression of swinery; and cost is low; mixed feeding is administered, easy to use, thus the defect eliminated in above-mentioned background technology.
In order to solve above-mentioned technical problem, the technical scheme is that
A kind of pharmaceutical composition of preventing and treating and purification pig blue-ear disease, including the raw medicinal material of following weight portion:
Acetylisovaleryl tylosin (safe ten thousand rhzomorphs) 4-10 part;
Sulfameter sodium or doxycycline hydrochloride 15-20 part;
Trimethoxy pyrimidine (TMP) or SDM (DVD) 2-6 part;
Semen Coicis 5-15 part;
Poria 5-15 part;
Oligofructose 1-5 part;
Oral anhydrous glucose 20-30 part;
Adjuvant 18-24 part.
As one optimization, described a kind of preventing and treating and the pharmaceutical composition of purification pig blue-ear disease, it includes the raw medicinal material of following weight portion:
Acetylisovaleryl tylosin (safe ten thousand rhzomorphs) 5 parts;
Sulfameter sodium or doxycycline hydrochloride 20 parts;
Trimethoxy pyrimidine (TMP) or SDM (DVD) 4 parts;
Semen Coicis 10 parts;
10 parts of Poria;
Oligofructose 2 parts;
Oral anhydrous glucose 25 parts;
Adjuvant 24 parts.
Further optimizing as one, described adjuvant is yellow auxiliary U.S. powder.
Described a kind of preventing and treating and the preparation method of the pharmaceutical composition of purification pig blue-ear disease, comprise the steps:
1) weighing raw medicinal material Semen Coicis, Poria, in Constant Temp. Oven, 90 DEG C of constant temperature dryings are��1% to water content (mass percent), and micronizing is to 150 orders respectively, are then sufficiently mixed uniformly in blender;
2) weigh each component respectively, according to equal increments method, use blender progressively mix homogeneously, obtain described pharmaceutical composition.
Described a kind of preventing and treating and the application of the pharmaceutical composition of purification pig blue-ear disease, in every 1000Kg feedstuff, add 1000g of the present invention.
The pathogenesis of pig blue-ear disease: after Virus entry body, poison immunocyte, especially macrophage, immunocyte is made to lose phagocytosis pathogen and assist the ability of damaged tissue repair, make body's immunity decline or lose, lose the ability of toxin expelling ability and eubolism further, noxious substance is accumulated in vivo, accelerate whole function of immune system weaken or lose, and then secondary infection other diseases, now, Drug abuse, make the beneficial microbe colony in intestinal unbalance, digestive functional disturbance, affect the absorption of nutrient substance, artificial increase additionally stress again, toxic and side effects such as medicine, injection etc. stress, death certainly will be accelerated.
According to above-mentioned theory, the invention provides such a preventing and treating and purify the pharmaceutical composition of pig blue-ear disease, comprising: acetylisovaleryl tylosin, sulfameter sodium or doxycycline hydrochloride, trimethoxy pyrimidine (TMP) or SDM (DVD), Semen Coicis, Poria, oligofructose, oral anhydrous glucose, (yellow auxiliary U.S. powder, as adjuvant, makes diluent and the anticaking agents of principal agent to yellow auxiliary U.S. powder in formula, can also replace with other, but low than other of yellow auxiliary U.S. powder cost).
Pharmacological action or the function of each component of the present invention are as follows:
The acetylisovaleryl tylosin selected: for a new generation's Macrolide animal specific antibiotic, its bioavailability is high, activity stabilized, be not likely to produce drug resistance, its metabolite is not only to causing the antibacterial of respiratory tract disease, mycoplasma etc. to have powerful killing action, simultaneously can also immune cell activated, make macrophage increasing number in body, the ability of phagocytosis pathogen strengthens, the secretion of immunologic active material such as lysozyme etc. can also be promoted, thus the non-specific immunity of enhancing body, it is effectively improved the immunosuppressive action of PRRS virus.
The sulfameter sodium selected or doxycycline hydrochloride: has a broad antifungal spectrum, the various sensitive organisms of reproductive tract, urinary tract, respiratory tract and body surface local are infected effectively, and untoward reaction are little by stable in properties, with synergist TMP or DVD coupling, antibacterial activity can strengthen 10-30 times.
The trimethoxy pyrimidine (TMP) selected or SDM (DVD): antibacterial range is wide, absorption for oral administration is rapidly, high sensitive organism has escherichia coli, Salmonella, fusobacterium, pasteurellosis bacillus, streptococcus, hemophilus influenza, anthrax bacillus etc., and sensitive organism has Brucella, staphylococcus, enterococcus, actinomycetes, streptococcus meningitidis, Bacillus proteus, corynebacterium etc. Curative effect can be obviously enhanced with sulfa drugs compatibility and be not likely to produce drug resistance.
The Semen Coicis selected: dampness removing spleen invigorating, clearing away heat and discharging pus. Cure mainly edema, damp-warm diseases, lung abscess; Acute appendicitis etc., clinical experiment confirms, Semen Coicis has certain antibacterial, antiviral efficacy.
The Poria selected: promoting diuresis to eliminate damp pathogen, spleen invigorating, for edema oliguria, may advantageously facilitate discharge bodily waste.
The oligofructose selected: be a kind of natural active matter. There is regulating intestinal canal flora, breed the health cares such as bacillus bifidus, promotion alimentation, immunomodulating, the clean intestinal of toxin expelling, two-ways regulation microecological balance are had obvious effect. It is described as the additive growth-promoting material of new generation of most potentiality after the antibiotic epoch.
The oral anhydrous glucose selected: seasoning, hepatoprotective, supplements energy, promotes metabolism.
The auxiliary U.S. powder of Huang selected: dispersant, as principal agent carrier, anti-caking.
After adopting such scheme, all kinds of crude drug of the present invention complement each other, and have the effect of heat clearing away toxin expelling, anti-inflammation, protection intestinal beneficial flora, raising immunity of organisms, and preventing and treating and purification pig blue-ear disease are had significant effect.
Compared with prior art, the invention have the characteristics that:
1) pathogen can be killed, prevent and treat various mixing or secondary infection;
2) protection intestinal beneficial microbes flora;
3) toxin expelling is promoted, releases immunosuppressant, improve the immunologic function of body that preventing and treating and purification pig blue-ear disease are had significant effect.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in detail.
Embodiment 1
A kind of pharmaceutical composition of preventing and treating and purification pig blue-ear disease, including the raw medicinal material of following weight portion:
Acetylisovaleryl tylosin (safe ten thousand rhzomorphs) 4 parts;
Sulfameter sodium or doxycycline hydrochloride 15 parts;
Trimethoxy pyrimidine (TMP) or SDM (DVD) 2 parts;
Semen Coicis 5 parts;
5 parts of Poria;
Oligofructose 1 part;
Oral anhydrous glucose 20 parts.
Described a kind of preventing and treating and the pharmaceutical composition of purification pig blue-ear disease, also include the auxiliary U.S. powder of Huang of 18 parts of weight portions as adjuvant.
Described a kind of preventing and treating and the preparation method of the pharmaceutical composition of purification pig blue-ear disease, comprise the steps:
1) weighing raw medicinal material Semen Coicis, Poria, in Constant Temp. Oven, 90 DEG C of constant temperature drying to water content are��1%, and micronizing is to 150 orders respectively, are then sufficiently mixed uniformly in blender;
2) weigh each component respectively, according to equal increments method, use blender progressively mix homogeneously, obtain described pharmaceutical composition.
Embodiment 2
A kind of pharmaceutical composition of preventing and treating and purification pig blue-ear disease, including the raw medicinal material of following weight portion:
Acetylisovaleryl tylosin (safe ten thousand rhzomorphs) 10 parts;
Sulfameter sodium or doxycycline hydrochloride 20 parts;
Trimethoxy pyrimidine (TMP) or SDM (DVD) 6 parts;
Semen Coicis 15 parts;
15 parts of Poria;
Oligofructose 5 parts;
Oral anhydrous glucose 30 parts.
Described a kind of preventing and treating and the pharmaceutical composition of purification pig blue-ear disease, also include the auxiliary U.S. powder of Huang of 20 parts of weight portions as adjuvant.
Described a kind of preventing and treating and the preparation method of the pharmaceutical composition of purification pig blue-ear disease, comprise the steps:
1) weighing raw medicinal material Semen Coicis, Poria, in Constant Temp. Oven, 90 DEG C of constant temperature drying to water content are��1%, and micronizing is to 150 orders respectively, are then sufficiently mixed uniformly in blender;
2) weigh each component respectively, according to equal increments method, use blender progressively mix homogeneously, obtain described pharmaceutical composition.
Embodiment 3
A kind of pharmaceutical composition of preventing and treating and purification pig blue-ear disease, it includes the raw medicinal material of following weight portion:
Acetylisovaleryl tylosin (safe ten thousand rhzomorphs) 5 parts;
Sulfameter sodium or doxycycline hydrochloride 20 parts;
Trimethoxy pyrimidine (TMP) or SDM (DVD) 4 parts;
Semen Coicis 10 parts;
10 parts of Poria;
Oligofructose 2 parts;
Oral anhydrous glucose 25 parts.
Further optimize as one, described a kind of pharmaceutical composition prevented and treated and purify pig blue-ear disease, it is also possible to include the auxiliary U.S. powder of Huang of 24 parts of weight portions as adjuvant.
Described a kind of preventing and treating and the preparation method of the pharmaceutical composition of purification pig blue-ear disease, comprise the steps:
1) weighing raw medicinal material Semen Coicis, Poria, in Constant Temp. Oven, 90 DEG C of constant temperature drying to water content are��1%, and micronizing is to 150 orders respectively, are then sufficiently mixed uniformly in blender;
2) weigh each component respectively, according to equal increments method, use blender progressively mix homogeneously, obtain described pharmaceutical composition.
The preferred embodiment of the present invention 3.
The using method of the pharmaceutical composition of a kind of preventing and treating of the present invention and purification pig blue-ear disease: need to mix in feedstuff by the present invention, fully after mixing, for pig free choice feeding. On morbidity pig farm, being used for purifying reproductive and respiratory syndrome, in every 1000Kg feedstuff, use 1000g of the present invention, monthly with once, being used in conjunction 7-10 days, be used in conjunction two months every time, each two moon is with once afterwards.On pig farm of not falling ill, being used for preventing and treating reproductive and respiratory syndrome, in every 1000Kg feedstuff, use 1000g of the present invention, two months with once, being used in conjunction 7-10 days every time.
Application Example 1
Scale pig farm, Fujian, there is rapid breathing in 1300 bull DLY three way cross nursery pig, and body temperature raises more than 40 DEG C, and part pig feed is for waste absolutely, ear skin, arm, umbilical part, abdomen inferior area skin cyanosis or rubescent, is pig blue-ear disease through laboratory diagnosis.
Adopt spice of the present invention to feed treatment, in every 1000Kg feedstuff, use 1000g of the present invention, be used in conjunction 10 days.
After 1 day, major part pig respiratory symptom is alleviated, and body temperature is slightly decreased. After 5 days, appetite, body temperature recover normal substantially.
The medication simultaneously of the pig in each each stage of age in days of whole audience pig, again continuously with 10 days after one month, the each two moon is with once afterwards, each medication is in combination with pig house environment strict sterilization measure, whole audience pig sampling observation after six months, 95.3% during with poison pig positive rate by non-medication is reduced to 41.6%, uses 1 year continuously, whole audience band poison positive pig has 1.4%, such as table 1.
Application Example 2
Scale pig farm, Guangxi, there is dyspnea in 900 bull DLY three way cross nursery pig, and body temperature raises more than 40 DEG C, and major part pig appetite is decreased obviously or useless exhausted, ear skin, arm, umbilical part, abdomen inferior area skin cyanosis or rubescent, is pig blue-ear disease through laboratory diagnosis.
Adopt spice of the present invention to feed treatment, in every 1000Kg feedstuff, use 1000g of the present invention, be used in conjunction 10 days.
After 1 day, major part pig respiratory symptom is alleviated, and body temperature is slightly decreased. After 7 days, appetite, body temperature recover normal substantially.
The medication simultaneously of the pig in each each stage of age in days of whole audience pig, again continuously with 10 days after one month, the each two moon is with once afterwards, each medication is in combination with pig house environment strict sterilization measure, whole audience pig sampling observation after six months, 96.1% during with poison pig positive rate by non-medication is reduced to 44.3%, uses 1 year continuously, whole audience band poison positive pig has 2.1%, such as table 2.
Application Example 3
Scale pig farm, Jiangxi, there is abdomen formula difficulty in 1000 bull DLY three way cross nursery pig, and body temperature raises more than 40 DEG C, and part pig appetite declines or do not eat, ear, basal part of the ear portion, muzzle, umbilical part, abdomen inferior area skin cyanosis or rubescent, be pig blue-ear disease through laboratory diagnosis.
Adopt spice of the present invention to feed treatment, in every 1000Kg feedstuff, use 1000g of the present invention, be used in conjunction 10 days.
After 1 day, major part pig respiratory symptom is alleviated, and body temperature is slightly decreased. After 5 days, appetite, body temperature recover normal substantially.
The medication simultaneously of the pig in each each stage of age in days of whole audience pig, again continuously with 10 days after one month, the each two moon is with once afterwards, each medication is in combination with pig house environment strict sterilization measure, whole audience pig sampling observation after six months, 91.8% during with poison pig positive rate by non-medication is reduced to 36.7%, uses 1 year continuously, whole audience band poison positive pig has 1.2%, such as table 3.
Table 1 uses pig farm reproductive and respiratory syndrome positive rate (%) (plant one) before and after pharmaceutical composition of the present invention
Table 2 uses pig farm reproductive and respiratory syndrome positive rate (%) (plant two) before and after pharmaceutical composition of the present invention
Table 3 uses pig farm reproductive and respiratory syndrome positive rate (%) (plant three) before and after pharmaceutical composition of the present invention
Drugs compared formula: tartaric acid safe ten thousand rhzomorph 10 parts, sulfamonomethoxine sodium 20 parts, trimethoprim 4 parts, anhydrous glucose 30 parts.
From table 1, table 2, table 3 result of the test it can be seen that embodiment three best results, adhere to that reproductive and respiratory syndrome positive field thoroughly can be converted into negative field for 1 year by medication.
Claims (5)
1. the pharmaceutical composition of a preventing and treating and purification pig blue-ear disease, it is characterised in that: include the raw medicinal material of following weight portion:
Acetylisovaleryl tylosin 4-10 part;
Sulfameter sodium or doxycycline hydrochloride 15-20 part;
Trimethoxy pyrimidine TMP or SDM DVD2-6 part;
Semen Coicis 5-15 part;
Poria 5-15 part;
Oligofructose 1-5 part;
Oral anhydrous glucose 20-30 part;
Adjuvant 18-24 part.
2. the pharmaceutical composition of a kind of preventing and treating as claimed in claim 1 and purification pig blue-ear disease, it is characterised in that: include the raw medicinal material of following weight portion:
Acetylisovaleryl tylosin 5 parts;
Sulfameter sodium or doxycycline hydrochloride 20 parts;
Trimethoxy pyrimidine TMP or SDM DVD4 part;
Semen Coicis 10 parts;
10 parts of Poria;
Oligofructose 2 parts;
Oral anhydrous glucose 25 parts;
Adjuvant 24 parts.
3. the pharmaceutical composition of a kind of preventing and treating as claimed in claim 1 and purification pig blue-ear disease, it is characterised in that: adjuvant is yellow auxiliary U.S. powder.
4. the preparation method of the pharmaceutical composition of a kind of preventing and treating as claimed in claim 1 and purification pig blue-ear disease, it is characterised in that: comprise the steps:
1) weighing raw medicinal material Semen Coicis, Poria, in Constant Temp. Oven, 90 DEG C of constant temperature drying to water content are��1%, and micronizing is to 150 orders respectively, are then sufficiently mixed uniformly in blender;
2) weigh each component respectively, according to equal increments method, use blender progressively mix homogeneously, obtain described pharmaceutical composition;
Invention preferred embodiment 3.
5. the pharmaceutical composition of a preventing and treating and purification pig blue-ear disease is applied to preventing and treating and purifies pig blue-ear disease, it is characterised in that: in every 1000Kg feedstuff, add the pharmaceutical composition 1000g of a kind of preventing and treating as claimed in claim 1 and purification pig blue-ear disease.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610042736.4A CN105641548A (en) | 2016-01-22 | 2016-01-22 | Medicine composition for preventing, treating and purifying porcine reproductive and respiratory syndrome and preparing method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610042736.4A CN105641548A (en) | 2016-01-22 | 2016-01-22 | Medicine composition for preventing, treating and purifying porcine reproductive and respiratory syndrome and preparing method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105641548A true CN105641548A (en) | 2016-06-08 |
Family
ID=56487881
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610042736.4A Pending CN105641548A (en) | 2016-01-22 | 2016-01-22 | Medicine composition for preventing, treating and purifying porcine reproductive and respiratory syndrome and preparing method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105641548A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101780270A (en) * | 2010-03-24 | 2010-07-21 | 天津生机集团股份有限公司 | Compound soluble powder for treating respiratory diseases of birds |
| CN101780266A (en) * | 2010-03-24 | 2010-07-21 | 天津生机集团股份有限公司 | Compound preparation for preventing and treating respiratory disease of livestock and poultry |
| CN103446171A (en) * | 2013-08-30 | 2013-12-18 | 天津生机集团股份有限公司 | Composition for treating swine respiratory tract infection and preparation method thereof |
-
2016
- 2016-01-22 CN CN201610042736.4A patent/CN105641548A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101780270A (en) * | 2010-03-24 | 2010-07-21 | 天津生机集团股份有限公司 | Compound soluble powder for treating respiratory diseases of birds |
| CN101780266A (en) * | 2010-03-24 | 2010-07-21 | 天津生机集团股份有限公司 | Compound preparation for preventing and treating respiratory disease of livestock and poultry |
| CN103446171A (en) * | 2013-08-30 | 2013-12-18 | 天津生机集团股份有限公司 | Composition for treating swine respiratory tract infection and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 俞向前等: "中药添加剂对断奶仔猪免疫力及抗寄生虫感染的影响", 《中国兽药杂志》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101584747B (en) | Antibacterial antivirus Chinese medicinal composition for animal | |
| Allan et al. | Oregano improves reproductive performance of sows | |
| CN105395676B (en) | A kind of compound medicament composition for treating animal mycotoxicosis | |
| US20220265597A1 (en) | Antiviral effects of narasin in swine feed | |
| CN105287790A (en) | Paederia scandens extract and applications thereof | |
| CN115645417A (en) | Application of chenodeoxycholic acid in preparation of medicine or feed additive for treating or preventing porcine viral diarrhea | |
| CN101417018B (en) | Preparation method of animal injection capable of clearing away the heat-evil and expelling superficial evils, cooling blood and relieving dysentery | |
| CN105941870A (en) | Nanometer montmorillonite feed additive compound for detoxifying and diarrhea prevention of livestock and poultry | |
| CN115025101A (en) | Lithocholic acid-added medicament for preventing and treating mycotoxin poisoning and preparation method and application thereof | |
| CN102258529A (en) | Compound ivermectin injection and preparation method thereof | |
| CN105641548A (en) | Medicine composition for preventing, treating and purifying porcine reproductive and respiratory syndrome and preparing method and application thereof | |
| CN103417571A (en) | Composition for treating chicken mycoplasma respiratory infection and preparing method thereof | |
| CN103055219B (en) | A kind of respiratory diseases in pigs health care Chinese medicine powder and preparation technology thereof | |
| CN102755342B (en) | Compound paracetamol injection and preparation method thereof | |
| CN108969648B (en) | Pharmaceutical composition and application method thereof | |
| Rivera et al. | Effects of oral tilmicosin on health and performance in newly received beef heifers | |
| CN114748460B (en) | Medicine for treating calf cryptosporidium infection and application thereof | |
| CN109394881A (en) | Prevent and treat pure Chinese medicine composition of poultry enterotoxin syndrome and preparation method thereof and application method | |
| CN118045047B (en) | Bufonis venenum granule prepared by superfine pulverizing technology | |
| CN102688477A (en) | Medicinal composition for treating respiratory diseases of livestock | |
| CN109985022B (en) | Povidone iodine preparation and its preparing method and use | |
| CN101297892A (en) | Chinese medicinal composition for treating cough and asthma due to lung-heat and respiratory tract infection of bird | |
| CN103961363B (en) | A kind of pharmaceutical composition for treating pig bacterial respiratory tract disease and its preparation method and application | |
| CN116999458A (en) | Application of polyhexamethylene guanidine iodine hydrochloride in preparation of medicines or feed additives for preventing and treating animal diarrhea | |
| CN104069236B (en) | Compound bark of ash poplar flower effervescent granules |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160608 |
|
| RJ01 | Rejection of invention patent application after publication |