CN105617363A - Traditional Chinese medicine hemostatic powder and preparation method thereof - Google Patents
Traditional Chinese medicine hemostatic powder and preparation method thereof Download PDFInfo
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Abstract
The invention discloses traditional Chinese medicine hemostatic powder and a preparation method thereof. The traditional Chinese medicine hemostatic powder is prepared from, by mass, 10-20 parts of common bletilla pseudobulb, 5-10 parts of sophora japonica, 2-8 parts of typhae pollen, 3-6 parts of agrimonia pilosa ledeb, 2-6 parts of crinis carbonisatus, 8-20 parts of folium artemisiae argyi, 2-5 parts of sanguisorba officinalis, 2-8 parts of trachycarpus fortunei, 3-6 parts of panax notoginseng, 1-3 parts of mint, 10-15 parts of whey protein and 5-10 parts of collagen. The traditional Chinese medicine hemostatic powder is formed by compositing hemostatic traditional Chinese medicine, is used for hemorrhagic wounds, can quickly stop bleeding, greatly shortens bleeding time, and is safe to use and free of side effects.
Description
Technical field
The invention belongs to hemostatic material in medical use technical field, be specifically related to a kind of Chinese medicine hemostatic powder agent and preparation method thereof.
Background technology
The hemorrhage first cause being always up trauma patient death. At present, the hemorrhage effective control device of large artery trunks is only rested on operating-table, but for field or acute injury bleeding patients, it is sent on the road of rescue room and has missed best treatment time due to severe loss of blood after hemorrhage often, therefore, how the very first time efficiently control hemorrhage become current the most challenging, be also most important work. Compare the method that the surgical operation traditional with some controls hemostasis, have recently emerged the hemostatic material of some advanced persons and examination thorn may be used for field hemostasis or emergency survival hemostasis. Oxidized cellulose, Fibrin Glue and rubber polymer thorn etc. have been used as trying punishment in local hemostasis; And molecular sieve and chitosan are manufactured experimently as the local hemostasis of latest generation, its effect and safety are among everybody is studying at present; The restructuring activation blood coagulation VII factor (FVIIa) be occur recently for the optimal hemostasis agents of wound hemostasis, but by many group STOCHASTIC CONTROL experiments, the safety of wounded patient is needed to investigate by it.
Traditional hemostatic fashion mainly ties, press and dressing etc., main hemostasia products has first-aid kit, four-tailed bandage, hemostatic gauze, tourniquet and binder etc., these hemostatic materials can stop blooding in very short time and give treatment to patient, it is control hemorrhage main method, but in use or use after can there is great defect, be therefore extremely limited when clinical practice. Such as; sewing hemostasis is very effective for the wound hemorrhage of soft tissue and big blood vessel; but the haemostatic effect for the parenchymal viscera that fragility is relatively big and blood flow is abundant is very undesirable; and very easily cause pinprick or the hemorrhagic tissue injury of breach, thus having influence on the normal function of the parenchymal viscera such as kidney, brain; Blood capillary is pressed by pressing haemostatic with needing lasting several tens minutes, promotes platelet to assemble, and is control the small-sized the most direct hemorrhage hemostatic fashion of body surface, but but very undesirable for slightly substantial amounts of hemorrhage haemostatic effect. Tourniquet there is also a lot of defect in the process used: if tourniquet is improper to treatment of wounds or does not have correct taking the time and pressure, it is possible to can cause pain near wound, nerve injury, even cause tissue necrosis etc. time serious; Tourniquet is for some special and relatively common wounds, and the wound hemostasis effect such as such as in irregular shape, deep, narrow, arteriorrhexis is bad; Tourniquet is easier to come off, and causes secondary hemorrhage; The reaction that the use of tourniquet can bring out surgical wound surface surrounding soft tissue is congested, and oxygen content is decreased obviously. Visible, traditional hemostatic material can not meet modem surgical safe haemostasis and urgent trauma hemostasis clinical demand, and the weak point of these hemostatic fashion needs other novel hemostatic materials to make up.
Summary of the invention
The present invention provides a kind of Chinese medicine hemostatic powder agent and preparation method thereof, is composited by Hemostatic of traditional herb medicine, for hemorrhagic wound, can quick-acting haemostatic powder, substantially reduce the bleeding time, use safety, have no side effect.
To achieve these goals, the technical solution used in the present invention is:
Chinese medicine hemostatic powder agent, component and each constituent mass number are as follows: Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 20 parts, 5 ~ 10 parts of Flos Sophorae, Pollen Typhae 2 ~ 8 parts, Herba Agrimoniae 3 ~ 6 parts, Crinis Carbonisatus 2 ~ 6 parts, Folium Artemisiae Argyi 8 ~ 20 parts, Radix Sanguisorbae 2 ~ 5 parts, 2 ~ 8 parts of Petiolus Trachycarpi, Radix Notoginseng 3 ~ 6 parts, Herba Menthae 1 ~ 3 part, lactalbumin 10 ~ 15 parts, collagen protein 5 ~ 10 parts.
Described Chinese medicine hemostatic powder agent, component and each constituent mass number are preferably as follows: Pseudobulbus Bletillae (Rhizoma Bletillae) 15 parts, 5 parts of Flos Sophorae, Pollen Typhae 5 parts, Herba Agrimoniae 4 parts, Crinis Carbonisatus 5 parts, Folium Artemisiae Argyi 15 parts, Radix Sanguisorbae 3 parts, 5 parts of Petiolus Trachycarpi, Radix Notoginseng 4 parts, Herba Menthae 2.5 parts, lactalbumin 12 parts, collagen protein 6 parts.
Described Chinese medicine hemostatic powder agent, component and each constituent mass number are preferably as follows: Pseudobulbus Bletillae (Rhizoma Bletillae) 20 parts, 8 parts of Flos Sophorae, Pollen Typhae 4 parts, Herba Agrimoniae 5 parts, Crinis Carbonisatus 4 parts, Folium Artemisiae Argyi 10 parts, Radix Sanguisorbae 5 parts, 4 parts of Petiolus Trachycarpi, Radix Notoginseng 5 parts, Herba Menthae 2 parts, lactalbumin 13 parts, collagen protein 8 parts.
The preparation method of described Chinese medicine hemostatic powder agent, comprises the steps:
1) Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Sophorae, Pollen Typhae, Herba Agrimoniae, Crinis Carbonisatus, Folium Artemisiae Argyi, Radix Sanguisorbae, Petiolus Trachycarpi, Radix Notoginseng and Herba Menthae are mixed in mass parts ratio, pulverize;
2) in the powder body of step 1), add lactalbumin and collagen protein, stir with the rotating speed of 100 ~ 150rpm, 50 ~ 60 DEG C of dry 10 ~ 20h, obtain Chinese medicine hemostatic powder agent.
Step 2) medium speed is 120rpm.
Step 2) baking temperature is 55 DEG C.
Step 2) in drying time be 15h.
Containing gelling ingredient in Pseudobulbus Bletillae (Rhizoma Bletillae) in instant component, wound surface can form a kind of protecting film, and forms thrombosis to reach haemostatic effect with red cell agglutination; The action principle of Flos Sophorae be reduce blood vessel permeability; Pollen Typhae, Herba Agrimoniae, Crinis Carbonisatus, Folium Artemisiae Argyi, Radix Sanguisorbae and Petiolus Trachycarpi have Blood clotting.
Beneficial effect:
Hemostatic of traditional herb medicine is composited by Chinese medicine hemostatic powder agent provided by the invention, for hemorrhagic wound, can quick-acting haemostatic powder, substantially reduce the bleeding time, use safety, have no side effect.
Detailed description of the invention
Embodiment 1
Chinese medicine hemostatic powder agent, component and each constituent mass number are as follows: Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 20 parts, 5 ~ 10 parts of Flos Sophorae, Pollen Typhae 2 ~ 8 parts, Herba Agrimoniae 3 ~ 6 parts, Crinis Carbonisatus 2 ~ 6 parts, Folium Artemisiae Argyi 8 ~ 20 parts, Radix Sanguisorbae 2 ~ 5 parts, 2 ~ 8 parts of Petiolus Trachycarpi, Radix Notoginseng 3 ~ 6 parts, Herba Menthae 1 ~ 3 part, lactalbumin 10 ~ 15 parts, collagen protein 5 ~ 10 parts.
Preparation method, comprises the steps:
1) Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Sophorae, Pollen Typhae, Herba Agrimoniae, Crinis Carbonisatus, Folium Artemisiae Argyi, Radix Sanguisorbae, Petiolus Trachycarpi, Radix Notoginseng and Herba Menthae are mixed in mass parts ratio, pulverize;
2) in the powder body of step 1), add lactalbumin and collagen protein, stir with the rotating speed of 120rpm, 55 DEG C of dry 15h, obtain Chinese medicine hemostatic powder agent.
Embodiment 2
Chinese medicine hemostatic powder agent, component and each constituent mass number are as follows: Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 20 parts, 5 ~ 10 parts of Flos Sophorae, Pollen Typhae 2 ~ 8 parts, Herba Agrimoniae 3 ~ 6 parts, Crinis Carbonisatus 2 ~ 6 parts, Folium Artemisiae Argyi 8 ~ 20 parts, Radix Sanguisorbae 2 ~ 5 parts, 2 ~ 8 parts of Petiolus Trachycarpi, Radix Notoginseng 3 ~ 6 parts, Herba Menthae 1 ~ 3 part, lactalbumin 10 ~ 15 parts, collagen protein 5 ~ 10 parts.
Preparation method, comprises the steps:
1) Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Sophorae, Pollen Typhae, Herba Agrimoniae, Crinis Carbonisatus, Folium Artemisiae Argyi, Radix Sanguisorbae, Petiolus Trachycarpi, Radix Notoginseng and Herba Menthae are mixed in mass parts ratio, pulverize;
2) in the powder body of step 1), add lactalbumin and collagen protein, stir with the rotating speed of 120rpm, 55 DEG C of dry 15h, obtain Chinese medicine hemostatic powder agent.
Embodiment 3
Chinese medicine hemostatic powder agent, component and each constituent mass number are as follows: Pseudobulbus Bletillae (Rhizoma Bletillae) 15 parts, 5 parts of Flos Sophorae, Pollen Typhae 5 parts, Herba Agrimoniae 4 parts, Crinis Carbonisatus 5 parts, Folium Artemisiae Argyi 15 parts, Radix Sanguisorbae 3 parts, 5 parts of Petiolus Trachycarpi, Radix Notoginseng 4 parts, Herba Menthae 2.5 parts, lactalbumin 12 parts, collagen protein 6 parts.
Preparation method, comprises the steps:
1) Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Sophorae, Pollen Typhae, Herba Agrimoniae, Crinis Carbonisatus, Folium Artemisiae Argyi, Radix Sanguisorbae, Petiolus Trachycarpi, Radix Notoginseng and Herba Menthae are mixed in mass parts ratio, pulverize;
2) in the powder body of step 1), add lactalbumin and collagen protein, stir with the rotating speed of 120rpm, 55 DEG C of dry 15h, obtain Chinese medicine hemostatic powder agent.
Embodiment 4
Chinese medicine hemostatic powder agent, component and each constituent mass number are as follows: Pseudobulbus Bletillae (Rhizoma Bletillae) 20 parts, 8 parts of Flos Sophorae, Pollen Typhae 4 parts, Herba Agrimoniae 5 parts, Crinis Carbonisatus 4 parts, Folium Artemisiae Argyi 10 parts, Radix Sanguisorbae 5 parts, 4 parts of Petiolus Trachycarpi, Radix Notoginseng 5 parts, Herba Menthae 2 parts, lactalbumin 13 parts, collagen protein 8 parts.
Preparation method, comprises the steps:
1) Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Sophorae, Pollen Typhae, Herba Agrimoniae, Crinis Carbonisatus, Folium Artemisiae Argyi, Radix Sanguisorbae, Petiolus Trachycarpi, Radix Notoginseng and Herba Menthae are mixed in mass parts ratio, pulverize;
2) in the powder body of step 1), add lactalbumin and collagen protein, stir with the rotating speed of 120rpm, 55 DEG C of dry 15h, obtain Chinese medicine hemostatic powder agent.
Reference examples 1
The present embodiment is identical with the component of embodiment 4 and preparation method, differs only in, without lactalbumin and collagen protein.
Reference examples 2
The present embodiment is identical with the component of embodiment 4 and preparation method, differs only in, without Pseudobulbus Bletillae (Rhizoma Bletillae) and Flos Sophorae.
Surface wound hemostasis trial: take healthy rabbits 30, male and female half and half, body weight 2.3��2.8kg. Being randomly divided into 5 groups by sex, body weight, often group 6, male and female half and half, be respectively as follows: model control group, embodiment 1 ~ 5, reference examples 1 ~ 2 and YUNNAN BAIYAO group. First with depilatory to family's rabbit back depilation, with 1% pentobarbital sodium 30mg/kg auricular vein injecting anesthetic rabbit after 24h. No. 7 syringe needle are used to scratch in depilation peeling skin " # ", with substantially hemorrhage for degree. Being full of after wound surface until blood, wrap up embodiment 1 ~ 5, the Chinese medicine hemostatic powder agent of reference examples 1 ~ 2 and coating YUNNAN BAIYAO to wound respectively immediately, to wound surface is completely covered, model control group is left intact. Observing the hemorrhage of wound every 30s, dip in suction gently with filter paper bar until blood no longer oozes out, namely no longer speckle with till blood on filter paper bar, record required time is the bleeding time. Stopping blooding not yet more than 15min, pressing haemostatic, the bleeding time is in 15min. Result is in Table 1.
Table 1:
| Sample | Bleeding time/min |
| Embodiment 1 | 4.38 |
| Embodiment 2 | 4.59 |
| Embodiment 3 | 2.18 |
| Embodiment 4 | 2.24 |
| Reference examples 1 | 6.42 |
| Reference examples 2 | 5.1 3 --> |
| YUNNAN BAIYAO | 6.34 |
| Blank group | 8.32 |
The mensuration of BCI index:
First, people's whole blood that 100 �� L contain anticoagulant ACD (2.5% ACD, 10 �� L) adds in a little container; Secondly the CaCl2 solution (0.2mol/L) of 20 �� L is joined and blood carries out preliminary blood coagulation, then the sample that weight is 0.03g is poured in small container and covered into blood, more above-mentioned beaker is put into cultivation 10min in 37 DEG C of incubators; Afterwards 25ml deionized water is poured slowly in beaker along walls of beaker, does not destroy the blood solidified as far as possible, this beaker is inserted 5min in 37 DEG C of constant temperature digital display water bath chaders; Finally take out beaker and stand 5min, take out the liquid in a small amount of beaker afterwards on ultraviolet spectrophotometer, measure its absorbance at 542nm place. The BCI value of sample calculates such as formula:
Not BCI=100* (liquid absorbance at 542nm place after sample stops blooding)/(not adding the liquid of the sample absorbance at 542nm place), hemostatic capability and the BCI value of material are inversely proportional to, namely BCI value is more low, and the anthemorrhagic performance of material is more good.
The BCI index of comparing embodiment 1 ~ 4, reference examples 1 ~ 2 and commercially available YUNNAN BAIYAO, result is shown in Table 2.
Table 2:
| Sample | BCI index |
| Embodiment 1 | 28.45 |
| Embodiment 2 | 24.37 |
| Embodiment 3 | 5.76 |
| Embodiment 4 | 6.38 |
| Reference examples 1 | 74.62 |
| Reference examples 2 | 88.16 |
| YUNNAN BAIYAO | 91.17 |
Claims (7)
1. Chinese medicine hemostatic powder agent, it is characterised in that component and each constituent mass number are as follows: Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 20 parts, 5 ~ 10 parts of Flos Sophorae, Pollen Typhae 2 ~ 8 parts, Herba Agrimoniae 3 ~ 6 parts, Crinis Carbonisatus 2 ~ 6 parts, Folium Artemisiae Argyi 8 ~ 20 parts, Radix Sanguisorbae 2 ~ 5 parts, 2 ~ 8 parts of Petiolus Trachycarpi, Radix Notoginseng 3 ~ 6 parts, Herba Menthae 1 ~ 3 part, lactalbumin 10 ~ 15 parts, collagen protein 5 ~ 10 parts.
2. Chinese medicine hemostatic powder agent according to claim 1, it is characterised in that component and each constituent mass number are as follows: Pseudobulbus Bletillae (Rhizoma Bletillae) 15 parts, 5 parts of Flos Sophorae, Pollen Typhae 5 parts, Herba Agrimoniae 4 parts, Crinis Carbonisatus 5 parts, Folium Artemisiae Argyi 15 parts, Radix Sanguisorbae 3 parts, 5 parts of Petiolus Trachycarpi, Radix Notoginseng 4 parts, Herba Menthae 2.5 parts, lactalbumin 12 parts, collagen protein 6 parts.
3. Chinese medicine hemostatic powder agent according to claim 1, it is characterised in that component and each constituent mass number are as follows: Pseudobulbus Bletillae (Rhizoma Bletillae) 20 parts, 8 parts of Flos Sophorae, Pollen Typhae 4 parts, Herba Agrimoniae 5 parts, Crinis Carbonisatus 4 parts, Folium Artemisiae Argyi 10 parts, Radix Sanguisorbae 5 parts, 4 parts of Petiolus Trachycarpi, Radix Notoginseng 5 parts, Herba Menthae 2 parts, lactalbumin 13 parts, collagen protein 8 parts.
4. the preparation method of Chinese medicine hemostatic powder agent described in claim 1, it is characterised in that comprise the steps:
1) Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Sophorae, Pollen Typhae, Herba Agrimoniae, Crinis Carbonisatus, Folium Artemisiae Argyi, Radix Sanguisorbae, Petiolus Trachycarpi, Radix Notoginseng and Herba Menthae are mixed in mass parts ratio, pulverize;
2) in the powder body of step 1), add lactalbumin and collagen protein, stir with the rotating speed of 100 ~ 150rpm, 50 ~ 60 DEG C of dry 10 ~ 20h, obtain Chinese medicine hemostatic powder agent.
5. the preparation method of Chinese medicine hemostatic powder agent according to claim 4, it is characterised in that: step 2) medium speed is 120rpm.
6. the preparation method of Chinese medicine hemostatic powder agent according to claim 4, it is characterised in that: step 2) baking temperature is 55 DEG C.
7. the preparation method of Chinese medicine hemostatic powder agent according to claim 4, it is characterised in that: step 2) in drying time be 15h.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101757614A (en) * | 2010-02-22 | 2010-06-30 | 苏州汇涵医用科技发展有限公司 | Hemostat and preparation method thereof |
| CN104161995A (en) * | 2014-08-25 | 2014-11-26 | 河南科技大学第一附属医院 | Bleeding stopping and blood coagulating powder used for traumatic hemorrhage and preparation method thereof |
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2016
- 2016-02-29 CN CN201610110217.7A patent/CN105617363A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101757614A (en) * | 2010-02-22 | 2010-06-30 | 苏州汇涵医用科技发展有限公司 | Hemostat and preparation method thereof |
| CN104161995A (en) * | 2014-08-25 | 2014-11-26 | 河南科技大学第一附属医院 | Bleeding stopping and blood coagulating powder used for traumatic hemorrhage and preparation method thereof |
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| 蒋与刚等: "乳清蛋白的生物学作用研究进展", 《中国食品与营养》 * |
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