CN105616960A - Traditional Chinese medicine composition with anti-anemia effect as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine composition with anti-anemia effect as well as preparation method and application thereof Download PDFInfo
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- CN105616960A CN105616960A CN201610057619.5A CN201610057619A CN105616960A CN 105616960 A CN105616960 A CN 105616960A CN 201610057619 A CN201610057619 A CN 201610057619A CN 105616960 A CN105616960 A CN 105616960A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A—HUMAN NECESSITIES
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Abstract
The invention particularly relates to a traditional Chinese medicine composition with an anti-anemia effect as well as a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials: 800-1800 parts by weight of donkey skin, 27-41 parts by weight of liquorice, 6-16 parts by weight of ligusticum wallichii, 0.5-6.5 parts by weight of prepared rehmannia root, 9-20 parts by weight of Chinese angelica, 3-15 parts by weight of white paeony root, 0.5-6.5 parts by weight of poria cocos, 0.5-6.5 parts by weight of rhizoma pinelliae preparata, 0.5-6.5 parts by weight of rehmannia root, 0.5-2.5 parts by weight of vinegar processed rhizoma cyperi, 0.5-6.5 parts by weight of polygonatum odoratum, 0.5-6.5 parts by weight of radix angelicae dahuricae, 0.5-2.5 parts by weight of dried tangerine or orange peel, 0.5-6.5 parts by weight of radix ophiopogonis and 1-10 parts by weight of astragalus. The traditional Chinese medicine composition with the anti-anemia effect has the advantages that channel tropisms, properties and flavors of the traditional Chinese medicine raw materials are fully considered, and the ratio of the traditional Chinese medicine raw materials is selected, so that the traditional Chinese medicine raw materials coordinate with each other and are synergistic, and thus the anti-anemia effect is achieved.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition with anti-anemia action effect and preparation method thereof and purposes.
Background technology
Anemia refers to that in systemic circulation blood, red blood cell mass reduces to normal value. But owing in systemic circulation blood, the determination techniques of red blood cell mass is more complicated, so refer generally to the concentration of peripheral hemoglobin and blood clinically lower than the same age group of patient, with sex with the arm's length standard in area. The clinical manifestation of anemia is dizziness and blurred vision, fatigue and weak, low, low, the intellectual impairment of hypoimmunity, labor efficiency of body constitution etc.
Chinese patent literature CN1720977A discloses a kind of female nutritive tonic capsule, and its crude drug includes: Radix Glycyrrhizae, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Rhizoma Cyperi, Pericarpium Citri Reticulatae, Radix Ophiopogonis, the Radix Astragali etc., is used for treating insufficiency of vital energy and blood etc. But, there is the shortcomings such as composition complexity in above-mentioned Chinese medicine composition, thus limiting its application.
Therefore, study that novel therapeutic effect is good, toxic and side effects is little, that composition simply has the medicine of anti-anemia action effect is significant.
Summary of the invention
Therefore, the present invention provides that a kind of therapeutic effect is good, toxic and side effects is little, composition simply has the Chinese medicine composition of anti-anemia action effect, and then provides its preparation method and purposes.
For solving above-mentioned technical problem, the present invention is achieved through the following technical solutions:
The present invention provides a kind of Chinese medicine composition, and the crude drug composition of described Chinese medicine composition includes:
Donkey skin 800-1800 weight portion, Radix Glycyrrhizae 27-41 weight portion, Rhizoma Chuanxiong 6-16 weight portion, Radix Rehmanniae Preparata 0.5-6.5 weight portion, Radix Angelicae Sinensis 9-20 weight portion, Radix Paeoniae Alba 3-15 weight portion, Poria 0.5-6.5 weight portion, Rhizoma Pinelliae 0.5-6.5 weight portion, Radix Rehmanniae 0.5-6.5 weight portion, Rhizoma Cyperi (processed with vinegar) 0.5-2.5 weight portion, Rhizoma Polygonati Odorati 0.5-6.5 weight portion, Radix Angelicae Dahuricae 0.5-6.5 weight portion, Pericarpium Citri Reticulatae 0.5-2.5 weight portion, Radix Ophiopogonis 0.5-6.5 weight portion, Radix Astragali 1-10 weight portion.
Preferably, the above-mentioned Chinese medicine composition of the present invention, the crude drug composition of described Chinese medicine composition includes:
Donkey skin 1000-1600 weight portion, Radix Glycyrrhizae 30-38 weight portion, Rhizoma Chuanxiong 8-14 weight portion, Radix Rehmanniae Preparata 1-5 weight portion, Radix Angelicae Sinensis 11-18 weight portion, Radix Paeoniae Alba 5-12 weight portion, Poria 1-5 weight portion, Rhizoma Pinelliae 1-5 weight portion, Radix Rehmanniae 1-5 weight portion, Rhizoma Cyperi (processed with vinegar) 1-2 weight portion, Rhizoma Polygonati Odorati 1-5 weight portion, Radix Angelicae Dahuricae 1-5 weight portion, Pericarpium Citri Reticulatae 1-2 weight portion, Radix Ophiopogonis 1-5 weight portion, Radix Astragali 3-8 weight portion.
It is further preferred that the above-mentioned Chinese medicine composition of the present invention, the crude drug composition of described Chinese medicine composition includes:
Donkey skin 1300 weight portion, Radix Glycyrrhizae 35 weight portion, Rhizoma Chuanxiong 12 weight portion, Radix Rehmanniae Preparata 3 weight portion, Radix Angelicae Sinensis 15 weight portion, the Radix Paeoniae Alba 9 weight portion, Poria 3 weight portion, Rhizoma Pinelliae 3 weight portion, Radix Rehmanniae 3 weight portion, Rhizoma Cyperi (processed with vinegar) 2 weight portion, Rhizoma Polygonati Odorati 3 weight portion, the Radix Angelicae Dahuricae 3 weight portion, Pericarpium Citri Reticulatae 2 weight portion, Radix Ophiopogonis 3 weight portion, the Radix Astragali 6 weight portion; Or
Donkey skin 1200 weight portion, Radix Glycyrrhizae 37 weight portion, Rhizoma Chuanxiong 13 weight portion, Radix Rehmanniae Preparata 4 weight portion, Radix Angelicae Sinensis 17 weight portion, the Radix Paeoniae Alba 11 weight portion, Poria 4 weight portion, Rhizoma Pinelliae 4 weight portion, Radix Rehmanniae 4 weight portion, Rhizoma Cyperi (processed with vinegar) 1 weight portion, Rhizoma Polygonati Odorati 4 weight portion, the Radix Angelicae Dahuricae 4 weight portion, Pericarpium Citri Reticulatae 1 weight portion, Radix Ophiopogonis 4 weight portion, the Radix Astragali 7 weight portion; Or
Donkey skin 1400 weight portion, Radix Glycyrrhizae 36 weight portion, Rhizoma Chuanxiong 11 weight portion, Radix Rehmanniae Preparata 2 weight portion, Radix Angelicae Sinensis 13 weight portion, the Radix Paeoniae Alba 8 weight portion, Poria 2 weight portion, Rhizoma Pinelliae 2 weight portion, Radix Rehmanniae 2 weight portion, Rhizoma Cyperi (processed with vinegar) 1 weight portion, Rhizoma Polygonati Odorati 2 weight portion, the Radix Angelicae Dahuricae 2 weight portion, Pericarpium Citri Reticulatae 1 weight portion, Radix Ophiopogonis 2 weight portion, the Radix Astragali 5 weight portion; Or
Donkey skin 1600 weight portion, Radix Glycyrrhizae 38 weight portion, Rhizoma Chuanxiong 14 weight portion, Radix Rehmanniae Preparata 5 weight portion, Radix Angelicae Sinensis 18 weight portion, the Radix Paeoniae Alba 12 weight portion, Poria 5 weight portion, Rhizoma Pinelliae 4 weight portion, Radix Rehmanniae 5 weight portion, Rhizoma Cyperi (processed with vinegar) 2 weight portion, Rhizoma Polygonati Odorati 5 weight portion, the Radix Angelicae Dahuricae 5 weight portion, Pericarpium Citri Reticulatae 2 weight portion, Radix Ophiopogonis 5 weight portion, the Radix Astragali 8 weight portion; Or
Donkey skin 1000 weight portion, Radix Glycyrrhizae 30 weight portion, Rhizoma Chuanxiong 8 weight portion, Radix Rehmanniae Preparata 1 weight portion, Radix Angelicae Sinensis 11 weight portion, the Radix Paeoniae Alba 5 weight portion, Poria 1 weight portion, Rhizoma Pinelliae 1 weight portion, Radix Rehmanniae 1 weight portion, Rhizoma Cyperi (processed with vinegar) 1 weight portion, Rhizoma Polygonati Odorati 1 weight portion, the Radix Angelicae Dahuricae 1 weight portion, Pericarpium Citri Reticulatae 1 weight portion, Radix Ophiopogonis 1 weight portion, the Radix Astragali 3 weight portion.
The preparation method that the present invention also provides for above-mentioned Chinese medicine composition, comprises the following steps:
(1) Radix Glycyrrhizae of selected weight portion, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Rhizoma Pinelliae, Radix Rehmanniae, Rhizoma Cyperi (processed with vinegar), Rhizoma Polygonati Odorati, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Radix Ophiopogonis and the Radix Astragali are taken, extracting in water at least 1 time, with the gross weight of the mixture of Radix Glycyrrhizae, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Rhizoma Pinelliae, Radix Rehmanniae, Rhizoma Cyperi (processed with vinegar), Rhizoma Polygonati Odorati, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Radix Ophiopogonis and the Radix Astragali for benchmark, the water extraction of addition 2��20 weight times amount 0.5��20 hour every time, filter, merging filtrate, stand, concentration, obtain clear paste, standby;
(2) take the donkey skin of selected weight portion, soak at least 48 hours, the reflux, extract, that adds water at least 1 time, add the water extraction 0.5��30 hour of 2��20 weight times amount every time, filter, merging filtrate, add appropriate Alumen, stirring, mix homogeneously, stand, concentration, obtain concentrated solution, standby;
(3) described concentrated solution is filtered, be heated to reflux, be subsequently adding described clear paste, mix, stir, to obtain final product.
Preferably, the preparation method of the above-mentioned Chinese medicine composition of the present invention, comprise the following steps:
(1) Radix Glycyrrhizae of selected weight portion, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Rhizoma Pinelliae, Radix Rehmanniae, Rhizoma Cyperi (processed with vinegar), Rhizoma Polygonati Odorati, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Radix Ophiopogonis and the Radix Astragali are taken, extracting in water 1��5 time, with the gross weight of the mixture of Radix Glycyrrhizae, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Rhizoma Pinelliae, Radix Rehmanniae, Rhizoma Cyperi (processed with vinegar), Rhizoma Polygonati Odorati, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Radix Ophiopogonis and the Radix Astragali for benchmark, the water extraction of addition 4��16 weight times amount 0.5��10 hour every time, filter, merging filtrate, stand, concentration, obtain clear paste, standby;
(2) donkey skin of selected weight portion is taken, soak at least 48 hours, the reflux, extract, that adds water extracting in water 1��5 time, add the water extraction 0.5��20 hour of 2��15 weight times amount every time, filter, merging filtrate, adds appropriate Alumen, stirring, mix homogeneously, stand, concentration, obtains concentrated solution, standby;
(3) described concentrated solution is filtered, be heated to reflux, be subsequently adding described clear paste, mix, stir, to obtain final product.
It is further preferred that the preparation method of the above-mentioned Chinese medicine composition of the present invention, comprise the following steps:
(1) Radix Glycyrrhizae of selected weight portion is taken, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Rhizoma Pinelliae, Radix Rehmanniae, Rhizoma Cyperi (processed with vinegar), Rhizoma Polygonati Odorati, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Radix Ophiopogonis and the Radix Astragali, extracting in water 3 times, with Radix Glycyrrhizae, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Rhizoma Pinelliae, Radix Rehmanniae, Rhizoma Cyperi (processed with vinegar), Rhizoma Polygonati Odorati, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, the gross weight of the mixture of Radix Ophiopogonis and the Radix Astragali is benchmark, the water extraction of the 1st addition 8��12 weight times amount 1��5 hour, the water extraction of the 2nd addition 6��10 weight times amount 0.5��4 hour, the water extraction of the 3rd addition 6��10 weight times amount 0.5��2 hour, filter, merging filtrate, stand, it is 1.15-1.40 that supernatant A is concentrated at 50 DEG C relative density, obtain clear paste, standby,
(2) take the donkey skin of selected weight portion, soak at least 48 hours, the reflux, extract, that adds water 2 times, the water extraction of the 1st addition 6��10 weight times amount 12��18 hours, the water extraction of the 2nd addition 6��10 weight times amount 10��16 hours, filters, merging filtrate, add appropriate Alumen, stirring, mix homogeneously, stand, and being concentrated at 50 DEG C by supernatant B relative density is 1.03-1.12, obtain concentrated solution, standby;
(3) described concentrated solution is filtered, be heated to reflux, be subsequently adding described clear paste, mix, stir, to obtain final product.
It is further preferred that the preparation method of the above-mentioned Chinese medicine composition of the present invention, comprise the following steps:
(1) Radix Glycyrrhizae of selected weight portion is taken, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Rhizoma Pinelliae, Radix Rehmanniae, Rhizoma Cyperi (processed with vinegar), Rhizoma Polygonati Odorati, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Radix Ophiopogonis and the Radix Astragali, extracting in water 3 times, with Radix Glycyrrhizae, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Rhizoma Pinelliae, Radix Rehmanniae, Rhizoma Cyperi (processed with vinegar), Rhizoma Polygonati Odorati, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, the gross weight of the mixture of Radix Ophiopogonis and the Radix Astragali is benchmark, the water extraction of the 1st addition 9��11 weight times amount 2��4 hours, the water extraction of the 2nd addition 7��9 weight times amount 1��3 hour, the water extraction of the 3rd addition 7��9 weight times amount 0.5��1.5 hour, filter, merging filtrate, stand, it is 1.15-1.40 that supernatant A is concentrated at 50 DEG C relative density, obtain clear paste, standby,
(2) take the donkey skin of selected weight portion, soak at least 48 hours, the reflux, extract, that adds water 2 times, the water extraction of the 1st addition 7��9 weight times amount 14��16 hours, the water extraction of the 2nd addition 7��9 weight times amount 12��14 hours, filters, merging filtrate, add appropriate Alumen, stirring, mix homogeneously, stand, and being concentrated at 50 DEG C by supernatant B relative density is 1.03-1.12, obtain concentrated solution, standby;
(3) described concentrated solution is filtered, be heated to reflux, be subsequently adding described clear paste, mix, stir, to obtain final product.
It is further preferred that the preparation method of the above-mentioned Chinese medicine composition of the present invention, comprise the following steps:
(1) Radix Glycyrrhizae of selected weight portion is taken, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Rhizoma Pinelliae, Radix Rehmanniae, Rhizoma Cyperi (processed with vinegar), Rhizoma Polygonati Odorati, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Radix Ophiopogonis and the Radix Astragali, extracting in water 3 times, with Radix Glycyrrhizae, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Rhizoma Pinelliae, Radix Rehmanniae, Rhizoma Cyperi (processed with vinegar), Rhizoma Polygonati Odorati, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, the gross weight of the mixture of Radix Ophiopogonis and the Radix Astragali is benchmark, the water extraction of the 1st addition 10 weight times amount 3 hours, the water extraction of the 2nd addition 8 weight times amount 2 hours, the water extraction of the 3rd addition 8 weight times amount 1 hour, filter, merging filtrate, stand, it is 1.35 that supernatant A is concentrated at 50 DEG C relative density, obtain clear paste, standby,
(2) take the donkey skin of selected weight portion, soak at least 48 hours, the reflux, extract, that adds water 2 times, the water extraction of the 1st addition 8 weight times amount 15 hours, the water extraction of the 2nd addition 8 weight times amount 13 hours, filters, merging filtrate, add appropriate Alumen, stirring, mix homogeneously, stand, and being concentrated at 50 DEG C by supernatant B relative density is 1.07-1.09, obtain concentrated solution, standby;
(3) described concentrated solution is filtered, be heated to reflux, be subsequently adding described clear paste, mix, stir, to obtain final product.
The present invention also provides for including the preparation of above-mentioned Chinese medicine composition or including the preparation of the Chinese medicine composition that above-mentioned preparation method prepares,
Described Chinese medicine composition adds customary adjuvant, conventionally technique, makes acceptable tablet, capsule, powder, mixture, pill, colloid, unguentum, granule, solution, syrup, suppository, aerosol or injection clinically.
Described customary adjuvant is: filler, disintegrating agent, lubricant, stabilizer, binding agent, sweeting agent, correctives, preservative, substrate etc. Filler includes: dextrin, maltodextrin, starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.; Disintegrating agent includes: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linked carboxymethyl cellulose are received; Lubricant includes: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.; Stabilizer includes: polyvinylpyrrolidone, microcrystalline Cellulose, sodium carboxymethyl cellulose, sodium alginate, sucrose, agar, xanthan gum, pectin, hydroxypropyl methyl cellulose etc.; Binding agent includes: starch slurry, Mel, polyvinylpyrrolidone, hydroxypropyl methyl cellulose etc.; Sweeting agent includes: white sugar, crystal sugar, sucrose, fructose, glucose, saccharin sodium, aspartame, stevioside, cyclamate, neotame, sucralose, acesulfame potassium, xylitol, maltose, maltose alcohol, hydroxyl isomaltulose, mannitol etc.; Correctives includes: various sweeting agents and essence; Preservative includes: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, acetic acid chloroethene are fixed, Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods; Substrate includes: PEG6000, PEG4000, insect wax etc.
The present invention also provides for above-mentioned Chinese medicine composition, above-mentioned preparation method prepares Chinese medicine composition or the preparation of above-mentioned Chinese medicine composition have the application in the medicine of anti-anemia action effect in preparation.
Technical scheme has the advantage that
The present invention has in the Chinese medicine composition of anti-anemia action effect, and donkey skin is sweet flat, and tonifying blood and arresting bleeding, nourshing Yin and drynsessmoistening prescription, hit pathogenesis, reuses as monarch. The sweet temperature QI invigorating of the Radix Astragali, the Radix Rehmanniae, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Rhizoma Chuanxiong nourishing YIN and benefiting blood, blood-activating and qi-promoting, strengthen donkey skin and enrich blood the merit of YIN nourishing, supply donkey skin QI invigorating not enough partially, be ministerial drug altogether. In prescription, the product that donkey skin flesh and blood is in love, more Radix Rehmanniae Preparata, Radix Angelicae Sinensis, grow greasy easy raw phlegm-damp, therefore use Rhizoma Pinelliae drying dampness to eliminate phlegm, Pericarpium Citri Reticulatae regulate the flow of vital energy and in, the fragrant dry dehumidifying of the pungent temperature of the Radix Angelicae Dahuricae, the sweet light invigorating spleen to remove dampness of Poria; Rhizoma Cyperi depressed liver-energy dispersing and QI regulating, blood circulation depending on qi flow, take good care of the whole body; More Radix Ophiopogonis, Rhizoma Polygonati Odorati, nourish lung yin, dry with lung moistening, be adjuvant drug altogether. Making with Radix Glycyrrhizae, sweet profit is gentle, QI invigorating invigorating middle warmer, nourishing the lung to arrest cough, coordinating the actions of various ingredients in a prescription. Medicine-feeding is harmonious, and QI and blood must be supported, and cloudy blood must be grown, and asthenic fire must be put down, and hemorrhage must stop, and health is gentle and strong.
The present invention has the Chinese medicine composition of anti-anemia action effect, take into full account each Chinese medicine return through and nature and flavor, and select each Chinese medicine proportioning each other, make each Chinese medicine cooperate according to the compatibility relationship of " monarch, minister, help, make ", combined effect, thus playing anti-anemia action effect.
Detailed description of the invention
Technical scheme will be clearly and completely described below, it is clear that described embodiment is a part of embodiment of the present invention, rather than whole embodiments. Based on the embodiment in the present invention, the every other embodiment that those of ordinary skill in the art obtain under not making creative work premise, broadly fall into the scope of protection of the invention.
Embodiment 1
The crude drug composition of the present embodiment Chinese medicine composition includes:
Donkey skin 1300g, Radix Glycyrrhizae 35g, Rhizoma Chuanxiong 12g, Radix Rehmanniae Preparata 3g, Radix Angelicae Sinensis 15g, Radix Paeoniae Alba 9g, Poria 3g, Rhizoma Pinelliae 3g, Radix Rehmanniae 3g, Rhizoma Cyperi (processed with vinegar) 2g, Rhizoma Polygonati Odorati 3g, Radix Angelicae Dahuricae 3g, Pericarpium Citri Reticulatae 2g, Radix Ophiopogonis 3g, Radix Astragali 6g;
The preparation method of this Chinese medicine composition, comprises the following steps:
(1) Radix Glycyrrhizae of selected weight is taken, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Rhizoma Pinelliae, Radix Rehmanniae, Rhizoma Cyperi (processed with vinegar), Rhizoma Polygonati Odorati, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Radix Ophiopogonis and the Radix Astragali, extracting in water 3 times, with Radix Glycyrrhizae, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Rhizoma Pinelliae, Radix Rehmanniae, Rhizoma Cyperi (processed with vinegar), Rhizoma Polygonati Odorati, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, the gross weight of the mixture of Radix Ophiopogonis and the Radix Astragali is benchmark, the water extraction of the 1st addition 10 weight times amount 3 hours, the water extraction of the 2nd addition 8 weight times amount 2 hours, the water extraction of the 3rd addition 8 weight times amount 1 hour, filter, merging filtrate, stand, it is 1.35 that supernatant A is concentrated at 50 DEG C relative density, obtain clear paste, standby,
(2) take the donkey skin of selected weight, soak at least 48 hours, the reflux, extract, that adds water 2 times, the water extraction of the 1st addition 8 weight times amount 15 hours, the water extraction of the 2nd addition 8 weight times amount 13 hours, filters, merging filtrate, add appropriate Alumen, stirring, mix homogeneously, stand, and being concentrated at 50 DEG C by supernatant B relative density is 1.07-1.09, obtain concentrated solution, standby;
(3) described concentrated solution is filtered, be heated to reflux, be subsequently adding described clear paste, mix, stir, to obtain final product.
The present embodiment Chinese medicine composition adds customary adjuvant, conventionally technique, makes colloid.
Embodiment 2
The crude drug composition of the present embodiment Chinese medicine composition includes:
Donkey skin 1200g, Radix Glycyrrhizae 37g, Rhizoma Chuanxiong 13g, Radix Rehmanniae Preparata 4g, Radix Angelicae Sinensis 17g, Radix Paeoniae Alba 11g, Poria 4g, Rhizoma Pinelliae 4g, Radix Rehmanniae 4g, Rhizoma Cyperi (processed with vinegar) 1g, Rhizoma Polygonati Odorati 4g, Radix Angelicae Dahuricae 4g, Pericarpium Citri Reticulatae 1g, Radix Ophiopogonis 4g, Radix Astragali 7g;
The preparation method of this Chinese medicine composition, comprises the following steps:
(1) Radix Glycyrrhizae of selected weight is taken, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Rhizoma Pinelliae, Radix Rehmanniae, Rhizoma Cyperi (processed with vinegar), Rhizoma Polygonati Odorati, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Radix Ophiopogonis and the Radix Astragali, extracting in water 3 times, with Radix Glycyrrhizae, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Rhizoma Pinelliae, Radix Rehmanniae, Rhizoma Cyperi (processed with vinegar), Rhizoma Polygonati Odorati, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, the gross weight of the mixture of Radix Ophiopogonis and the Radix Astragali is benchmark, the water extraction of the 1st addition 9 weight times amount 4 hours, the water extraction of the 2nd addition 9 weight times amount 1 hour, the water extraction of the 3rd addition 7 weight times amount 1.5 hours, filter, merging filtrate, stand, it is 1.15-1.35 that supernatant A is concentrated at 50 DEG C relative density, obtain clear paste, standby,
(2) take the donkey skin of selected weight, soak at least 48 hours, the reflux, extract, that adds water 2 times, the water extraction of the 1st addition 7 weight times amount 16 hours, the water extraction of the 2nd addition 9 weight times amount 12 hours, filters, merging filtrate, add appropriate Alumen, stirring, mix homogeneously, stand, and being concentrated at 50 DEG C by supernatant B relative density is 1.03-1.09, obtain concentrated solution, standby;
(3) described concentrated solution is filtered, be heated to reflux, be subsequently adding described clear paste, mix, stir, to obtain final product.
The present embodiment Chinese medicine composition adds customary adjuvant, conventionally technique, makes capsule.
Embodiment 3
The crude drug composition of the present embodiment Chinese medicine composition includes:
Donkey skin 1400g, Radix Glycyrrhizae 36g, Rhizoma Chuanxiong 11g, Radix Rehmanniae Preparata 2g, Radix Angelicae Sinensis 13g, Radix Paeoniae Alba 8g, Poria 2g, Rhizoma Pinelliae 2g, Radix Rehmanniae 2g, Rhizoma Cyperi (processed with vinegar) 1g, Rhizoma Polygonati Odorati 2g, Radix Angelicae Dahuricae 2g, Pericarpium Citri Reticulatae 1g, Radix Ophiopogonis 2g, Radix Astragali 5g;
The preparation method of this Chinese medicine composition, comprises the following steps:
(1) Radix Glycyrrhizae of selected weight is taken, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Rhizoma Pinelliae, Radix Rehmanniae, Rhizoma Cyperi (processed with vinegar), Rhizoma Polygonati Odorati, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Radix Ophiopogonis and the Radix Astragali, extracting in water 3 times, with Radix Glycyrrhizae, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Rhizoma Pinelliae, Radix Rehmanniae, Rhizoma Cyperi (processed with vinegar), Rhizoma Polygonati Odorati, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, the gross weight of the mixture of Radix Ophiopogonis and the Radix Astragali is benchmark, the water extraction of the 1st addition 11 weight times amount 2 hours, the water extraction of the 2nd addition 7 weight times amount 3 hours, the water extraction of the 3rd addition 9 weight times amount 0.5 hour, filter, merging filtrate, stand, it is 1.35-1.40 that supernatant A is concentrated at 50 DEG C relative density, obtain clear paste, standby,
(2) take the donkey skin of selected weight, soak at least 48 hours, the reflux, extract, that adds water 2 times, the water extraction of the 1st addition 9 weight times amount 14 hours, the water extraction of the 2nd addition 7 weight times amount 14 hours, filters, merging filtrate, add appropriate Alumen, stirring, mix homogeneously, stand, and being concentrated at 50 DEG C by supernatant B relative density is 1.09-1.12, obtain concentrated solution, standby;
(3) described concentrated solution is filtered, be heated to reflux, be subsequently adding described clear paste, mix, stir, to obtain final product.
The present embodiment Chinese medicine composition adds customary adjuvant, conventionally technique, makes tablet.
Embodiment 4
The crude drug composition of the present embodiment Chinese medicine composition includes:
Donkey skin 1600g, Radix Glycyrrhizae 38g, Rhizoma Chuanxiong 14g, Radix Rehmanniae Preparata 5g, Radix Angelicae Sinensis 18g, Radix Paeoniae Alba 12g, Poria 5g, Rhizoma Pinelliae 4g, Radix Rehmanniae 5g, Rhizoma Cyperi (processed with vinegar) 2g, Rhizoma Polygonati Odorati 5g, Radix Angelicae Dahuricae 5g, Pericarpium Citri Reticulatae 2g, Radix Ophiopogonis 5g, Radix Astragali 8g;
The preparation method of this Chinese medicine composition, comprises the following steps:
(1) Radix Glycyrrhizae of selected weight is taken, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Rhizoma Pinelliae, Radix Rehmanniae, Rhizoma Cyperi (processed with vinegar), Rhizoma Polygonati Odorati, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Radix Ophiopogonis and the Radix Astragali, extracting in water 3 times, with Radix Glycyrrhizae, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Rhizoma Pinelliae, Radix Rehmanniae, Rhizoma Cyperi (processed with vinegar), Rhizoma Polygonati Odorati, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, the gross weight of the mixture of Radix Ophiopogonis and the Radix Astragali is benchmark, the water extraction of the 1st addition 8 weight times amount 5 hours, the water extraction of the 2nd addition 6 weight times amount 4 hours, the water extraction of the 3rd addition 6 weight times amount 2 hours, filter, merging filtrate, stand, it is 1.35-1.40 that supernatant A is concentrated at 50 DEG C relative density, obtain clear paste, standby,
(2) take the donkey skin of selected weight, soak at least 48 hours, the reflux, extract, that adds water 2 times, the water extraction of the 1st addition 10 weight times amount 12 hours, the water extraction of the 2nd addition 10 weight times amount 10 hours, filters, merging filtrate, add appropriate Alumen, stirring, mix homogeneously, stand, and being concentrated at 50 DEG C by supernatant B relative density is 1.03-1.09, obtain concentrated solution, standby;
(3) described concentrated solution is filtered, be heated to reflux, be subsequently adding described clear paste, mix, stir, to obtain final product.
The present embodiment Chinese medicine composition adds customary adjuvant, conventionally technique, makes capsule.
Embodiment 5
The crude drug composition of the present embodiment Chinese medicine composition includes:
Donkey skin 1000g, Radix Glycyrrhizae 30g, Rhizoma Chuanxiong 8g, Radix Rehmanniae Preparata 1g, Radix Angelicae Sinensis 11g, Radix Paeoniae Alba 5g, Poria 1g, Rhizoma Pinelliae 1g, Radix Rehmanniae 1g, Rhizoma Cyperi (processed with vinegar) 1g, Rhizoma Polygonati Odorati 1g, Radix Angelicae Dahuricae 1g, Pericarpium Citri Reticulatae 1g, Radix Ophiopogonis 1g, Radix Astragali 3g.
The preparation method of this Chinese medicine composition, comprises the following steps:
(1) Radix Glycyrrhizae of selected weight is taken, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Rhizoma Pinelliae, Radix Rehmanniae, Rhizoma Cyperi (processed with vinegar), Rhizoma Polygonati Odorati, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Radix Ophiopogonis and the Radix Astragali, extracting in water 3 times, with Radix Glycyrrhizae, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Rhizoma Pinelliae, Radix Rehmanniae, Rhizoma Cyperi (processed with vinegar), Rhizoma Polygonati Odorati, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, the gross weight of the mixture of Radix Ophiopogonis and the Radix Astragali is benchmark, the water extraction of the 1st addition 12 weight times amount 1 hour, the water extraction of the 2nd addition 10 weight times amount 0.5 hour, the water extraction of the 3rd addition 10 weight times amount 0.5 hour, filter, merging filtrate, stand, it is 1.15-1.35 that supernatant A is concentrated at 50 DEG C relative density, obtain clear paste, standby,
(2) take the donkey skin of selected weight, soak at least 48 hours, the reflux, extract, that adds water 2 times, the water extraction of the 1st addition 6 weight times amount 18 hours, the water extraction of the 2nd addition 6 weight times amount 16 hours, filters, merging filtrate, add appropriate Alumen, stirring, mix homogeneously, stand, and being concentrated at 50 DEG C by supernatant B relative density is 1.09-1.12, obtain concentrated solution, standby;
(3) described concentrated solution is filtered, be heated to reflux, be subsequently adding described clear paste, mix, stir, to obtain final product.
The present embodiment Chinese medicine composition adds customary adjuvant, conventionally technique, makes tablet.
Experimental exampleThe research of present composition anti-anemia action effect
Experimental example 1
1, experiment purpose
Tested by mice hemorrhagic anemia, study the Chinese medicine composition of the present invention impact on mice hemorrhagic anemia.
2, experiment material
2.1 for reagent thing
Experimental group: with the Chinese medicine composition of embodiment 1 preparation for supplying reagent thing, 2 times/day.
Matched group 1 group: with ferrous succinate sheet (Jinling Pharmaceutical Co., Ltd., Jinling Pharmaceutical Factory produces, and every containing ferrous succinate 0.1 gram) for supplying reagent thing, 4 times/day.
Matched group 2 groups: Chinese angelica blood supplementing ball (JiLin ZiXin Pharmacy Co., Ltd produces, composition: Radix Angelicae Sinensis and the Radix Astragali), 2 times/day.
2.2 laboratory animals and the situation of raising
(1) laboratory animal
Mice, SPF level, male and female half and half, body weight 18g-22g, purchased from Beijing Vital River Experimental Animals Technology Co., Ltd.. Licence is numbered: SCXK (capital) 2012-0001, the quality certification number: 11400700105593.
(2) rearing conditions
Experimental animal feeding in Ordinary Animal Lab, fluorescent lamp lighting, in the 12h light and shade cycle, freely drink water, diet, temperature 22 DEG C �� 2 DEG C, blow 6 times-10 times/h.
2.4 experiment materials
The full-automatic blood cell monitor of Abbott Laboratories CD3700, Americanized.
3, experimental technique
3.1 dosages
Experimental group low dose group: dosage is 1.4g/kg/ days;
Dosage group in experimental group: dosage is 2.7g/kg/ days;
Experimental group high dose group: dosage is 5.4g/kg/ days;
Matched group 1 group: dosage is 0.06g/kg/ days;
Matched group 2 groups: dosage is 1.8g/kg/ days.
3.2 medications
Route of administration is per os gastric infusion, and gastric infusion volume is 20mL/g body weight mice.
3.3 medicine preparations
Accurate weighing, for after reagent thing, adds appropriate amount of deionized water and is configured to desired concn.
3.4 experimental techniques
ICR mice 60, male and female half and half, body weight 18��22 grams, adaptability was raised after 5��7 days, was randomly divided in model group, experimental group low dose group, experimental group dosage group, experimental group high dose group, matched group 1 group and matched group 2 groups. Each organize every rathole socket of the eye and take a blood sample about 0.5mL modeling, ischemia 24 hours. Then, in experimental group low dose group, experimental group, dosage group, experimental group high dose group, matched group 1 group and matched group 2 groups each group give relative medicine, model group gives distilled water, administration volume 20mL/kg, once a day, successive administration 7 days, surveys RBC and HGB, its anti-anemia action effect of preliminary assessment in blood sampling in the 8th day.
4, statistical method
Experimental data is with " mean+SD" represent. Data first carry out homogeneity test of variance. Variance selects One-WayANOVA method to carry out comparing between each group together; Heterogeneity of variance selects t ' inspection to compare between organizing.
5, experimental result
Specific experiment result is as shown in table 1.
The table 1 impact on posthemorrhagic anemia mice RBC and HGB
Compare with model group:*P < 0.05,**P<0.01
As shown in Table 1, after (1) administration, in matched group 1 group, experimental group high dose group, experimental group, the RBC of dosage group is significantly raised, compares with model group and has significant difference (P < 0.01, P < 0.01, P < 0.05); (2) after administration, dosage group in matched group 1 group, experimental group high dose group, experimental group, experimental group low dose group HGB significantly raised, compare with model group and have significant difference (P < 0.05, P < 0.01, P < 0.05, P < 0.05).
This shows, the Chinese medicine composition of the embodiment of the present invention 1 preparation can improve the level of RBC and the HGB of posthemorrhagic anemia mice.
Experimental example 2
1, experiment purpose
By Induced By Iron Deficiency Anemia In Rats model, study the Chinese medicine composition of the present invention impact on Anemia in Rats, evaluate its anti-anemia action effect.
2, experiment material
2.1 for reagent thing
Experimental group: with the Chinese medicine composition of embodiment 1 preparation for supplying reagent thing, 2 times/day.
Matched group: with ferrous succinate sheet (Jinling Pharmaceutical Co., Ltd., Jinling Pharmaceutical Factory produces, and every containing ferrous succinate 0.1 gram) for supplying reagent thing, 4 times/day.
2.2 laboratory animals and the situation of raising
SD rat, SPF level, male and female half and half, body weight 60g-80g. Purchased from Beijing Vital River Experimental Animals Technology Co., Ltd.. Licence is numbered: SCXK (capital) 2012-0001, the quality certification number: 11400700086183.
Experimental animal feeding in SPF level animal housing, fluorescent lamp lighting, in the 12h light and shade cycle, freely drink water, diet, temperature 22 DEG C �� 2 DEG C, blow 6 times-10 times/h.
2.3 experimental apparatus
Abbott Laboratories CD3700 five classifies blood instrument, Americanized.
3, experimental technique
3.1 dosages
Experimental group low dose group: dosage is 0.9g/kg/ days;
Dosage group in experimental group: dosage is 1.8g/kg/ days;
Experimental group high dose group: dosage is 3.6g/kg/ days;
Matched group: dosage is 0.04g/kg/ days.
3.3 medications
Each administration group rat oral gavage gives institute's reagent thing, and gastric infusion volume is 10mL/kg body weight. Blank group and model group give equal-volume deionized water.
3.4 experimental techniques
After Animal adaptability is raised 5 days, randomly draw 12 animals as blank group, the low ferrum feedstuff of all the other animal feed, ad lib, drink deionized water, eyeground vein clump blood-letting 1��2 time weekly simultaneously, each 1mL, rat Hb is monitored in blood-letting simultaneously, as modeling rat average hemoglobin Hb��7.0g/L, stop blood-letting, model success.
Be randomly divided in experimental group low dose group, experimental group by modeling success animal dosage group, experimental group high dose group and matched group. Except blank group, each group continues the low ferrum feedstuff of feed, gastric infusion, every day 1 time, successive administration 6 weeks, and after administration 4 weeks, and after last administration, 1h takes a blood sample mensuration RBC and HGB.
4, statistical method
Experimental data is with " mean+SD" represent. Data first carry out homogeneity test of variance. Variance selects One-WayANOVA method to carry out comparing between each group together; Heterogeneity of variance selects t ' inspection to compare between organizing.
5, result
The impact of Induced By Iron Deficiency Anemia In Rats RBC content is as shown in table 2, and the impact of Induced By Iron Deficiency Anemia In Rats HGB content is as shown in table 3.
The table 2 impact on Induced By Iron Deficiency Anemia In Rats RBC content
Compare with blank group:#P<0.05,##P < 0.01; Compare with model group:*P<0.05,**P<0.01
As shown in Table 2, before (1) administration, in experimental group low dose group, experimental group, the RBC content of dosage group, experimental group high dose group and control rats substantially reduces, and compares with blank group and has significant difference (P < 0.01); (2) after being administered 4 weeks, the RBC content of control rats is significantly raised, compares with blank group and model group, all has significant difference (P < 0.01); (3) after being administered 4 weeks, experimental group high dose group RBC content is significantly raised, compares with model group, has significant difference (P < 0.05); (4) after being administered 6 weeks, comparing with blank group, matched group RBC content has significant difference (P < 0.01); (5) after being administered 6 weeks, experimental group high dose group RBC content is significantly raised, compares with blank group and model group, all has significant difference (P < 0.05, P < 0.01).
The table 3 impact on Induced By Iron Deficiency Anemia In Rats HGB content
Compare with blank group:#P<0.05,##P < 0.01; Compare with model group:*P<0.05,**P<0.01
As shown in Table 3, before (1) administration, in experimental group low dose group, experimental group, the HGB content of dosage group, experimental group high dose group and control rats substantially reduces, and compares with blank group and has significant difference (P < 0.01); (2), after being administered 4 weeks and after administration 6 weeks, each HGB content organizing rat is significantly raised, compares with blank group, all has significant difference (P < 0.01); (3) after being administered 4 weeks and administration 6 weeks after, the HGB content of matched group and experimental group high dose group rat is significantly raised, compares with model group and all has significant difference (P < 0.01). This shows, the Chinese medicine composition of the embodiment of the present invention 1 preparation can improve the level of RBC and the HGB of iron deficiency anemia mice.
By experimental example 1 and experimental example 2 it can be seen that Chinese medicine composition prepared by the embodiment of the present invention 1 has certain anti-anemia action effect.
To sum up, the present invention has the Chinese medicine composition of anti-anemia action effect, take into full account each Chinese medicine return through and nature and flavor, and select each Chinese medicine proportioning each other, make each Chinese medicine cooperate according to the compatibility relationship of " monarch, minister, help, make ", combined effect, thus playing anti-anemia action effect.
Obviously, above-described embodiment is only for clearly demonstrating example, and is not the restriction to embodiment. For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description. Here without also cannot all of embodiment be given exhaustive. And the apparent change thus extended out or variation are still among the protection domain of the invention.
Claims (10)
1. a Chinese medicine composition, it is characterised in that the crude drug composition of described Chinese medicine composition includes:
Donkey skin 800-1800 weight portion, Radix Glycyrrhizae 27-41 weight portion, Rhizoma Chuanxiong 6-16 weight portion, Radix Rehmanniae Preparata 0.5-6.5 weight portion, Radix Angelicae Sinensis 9-20 weight portion, Radix Paeoniae Alba 3-15 weight portion, Poria 0.5-6.5 weight portion, Rhizoma Pinelliae 0.5-6.5 weight portion, Radix Rehmanniae 0.5-6.5 weight portion, Rhizoma Cyperi (processed with vinegar) 0.5-2.5 weight portion, Rhizoma Polygonati Odorati 0.5-6.5 weight portion, Radix Angelicae Dahuricae 0.5-6.5 weight portion, Pericarpium Citri Reticulatae 0.5-2.5 weight portion, Radix Ophiopogonis 0.5-6.5 weight portion, Radix Astragali 1-10 weight portion.
2. Chinese medicine composition according to claim 1, it is characterised in that the crude drug composition of described Chinese medicine composition includes:
Donkey skin 1000-1600 weight portion, Radix Glycyrrhizae 30-38 weight portion, Rhizoma Chuanxiong 8-14 weight portion, Radix Rehmanniae Preparata 1-5 weight portion, Radix Angelicae Sinensis 11-18 weight portion, Radix Paeoniae Alba 5-12 weight portion, Poria 1-5 weight portion, Rhizoma Pinelliae 1-5 weight portion, Radix Rehmanniae 1-5 weight portion, Rhizoma Cyperi (processed with vinegar) 1-2 weight portion, Rhizoma Polygonati Odorati 1-5 weight portion, Radix Angelicae Dahuricae 1-5 weight portion, Pericarpium Citri Reticulatae 1-2 weight portion, Radix Ophiopogonis 1-5 weight portion, Radix Astragali 3-8 weight portion.
3. Chinese medicine composition according to claim 2, it is characterised in that the crude drug composition of described Chinese medicine composition includes:
Donkey skin 1300 weight portion, Radix Glycyrrhizae 35 weight portion, Rhizoma Chuanxiong 12 weight portion, Radix Rehmanniae Preparata 3 weight portion, Radix Angelicae Sinensis 15 weight portion, the Radix Paeoniae Alba 9 weight portion, Poria 3 weight portion, Rhizoma Pinelliae 3 weight portion, Radix Rehmanniae 3 weight portion, Rhizoma Cyperi (processed with vinegar) 2 weight portion, Rhizoma Polygonati Odorati 3 weight portion, the Radix Angelicae Dahuricae 3 weight portion, Pericarpium Citri Reticulatae 2 weight portion, Radix Ophiopogonis 3 weight portion, the Radix Astragali 6 weight portion; Or
Donkey skin 1200 weight portion, Radix Glycyrrhizae 37 weight portion, Rhizoma Chuanxiong 13 weight portion, Radix Rehmanniae Preparata 4 weight portion, Radix Angelicae Sinensis 17 weight portion, the Radix Paeoniae Alba 11 weight portion, Poria 4 weight portion, Rhizoma Pinelliae 4 weight portion, Radix Rehmanniae 4 weight portion, Rhizoma Cyperi (processed with vinegar) 1 weight portion, Rhizoma Polygonati Odorati 4 weight portion, the Radix Angelicae Dahuricae 4 weight portion, Pericarpium Citri Reticulatae 1 weight portion, Radix Ophiopogonis 4 weight portion, the Radix Astragali 7 weight portion; Or
Donkey skin 1400 weight portion, Radix Glycyrrhizae 36 weight portion, Rhizoma Chuanxiong 11 weight portion, Radix Rehmanniae Preparata 2 weight portion, Radix Angelicae Sinensis 13 weight portion, the Radix Paeoniae Alba 8 weight portion, Poria 2 weight portion, Rhizoma Pinelliae 2 weight portion, Radix Rehmanniae 2 weight portion, Rhizoma Cyperi (processed with vinegar) 1 weight portion, Rhizoma Polygonati Odorati 2 weight portion, the Radix Angelicae Dahuricae 2 weight portion, Pericarpium Citri Reticulatae 1 weight portion, Radix Ophiopogonis 2 weight portion, the Radix Astragali 5 weight portion; Or
Donkey skin 1600 weight portion, Radix Glycyrrhizae 38 weight portion, Rhizoma Chuanxiong 14 weight portion, Radix Rehmanniae Preparata 5 weight portion, Radix Angelicae Sinensis 18 weight portion, the Radix Paeoniae Alba 12 weight portion, Poria 5 weight portion, Rhizoma Pinelliae 4 weight portion, Radix Rehmanniae 5 weight portion, Rhizoma Cyperi (processed with vinegar) 2 weight portion, Rhizoma Polygonati Odorati 5 weight portion, the Radix Angelicae Dahuricae 5 weight portion, Pericarpium Citri Reticulatae 2 weight portion, Radix Ophiopogonis 5 weight portion, the Radix Astragali 8 weight portion; Or
Donkey skin 1000 weight portion, Radix Glycyrrhizae 30 weight portion, Rhizoma Chuanxiong 8 weight portion, Radix Rehmanniae Preparata 1 weight portion, Radix Angelicae Sinensis 11 weight portion, the Radix Paeoniae Alba 5 weight portion, Poria 1 weight portion, Rhizoma Pinelliae 1 weight portion, Radix Rehmanniae 1 weight portion, Rhizoma Cyperi (processed with vinegar) 1 weight portion, Rhizoma Polygonati Odorati 1 weight portion, the Radix Angelicae Dahuricae 1 weight portion, Pericarpium Citri Reticulatae 1 weight portion, Radix Ophiopogonis 1 weight portion, the Radix Astragali 3 weight portion.
4. the preparation method of the Chinese medicine composition described in an any one of claim 1-3, it is characterised in that comprise the following steps:
(1) Radix Glycyrrhizae of selected weight portion, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Rhizoma Pinelliae, Radix Rehmanniae, Rhizoma Cyperi (processed with vinegar), Rhizoma Polygonati Odorati, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Radix Ophiopogonis and the Radix Astragali are taken, extracting in water at least 1 time, with the gross weight of the mixture of Radix Glycyrrhizae, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Rhizoma Pinelliae, Radix Rehmanniae, Rhizoma Cyperi (processed with vinegar), Rhizoma Polygonati Odorati, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Radix Ophiopogonis and the Radix Astragali for benchmark, the water extraction of addition 2��20 weight times amount 0.5��20 hour every time, filter, merging filtrate, stand, concentration, obtain clear paste, standby;
(2) take the donkey skin of selected weight portion, soak at least 48 hours, the reflux, extract, that adds water at least 1 time, add the water extraction 0.5��30 hour of 2��20 weight times amount every time, filter, merging filtrate, add appropriate Alumen, stirring, mix homogeneously, stand, concentration, obtain concentrated solution, standby;
(3) described concentrated solution is filtered, be heated to reflux, be subsequently adding described clear paste, mix, stir, to obtain final product.
5. the preparation method of Chinese medicine composition according to claim 4, it is characterised in that comprise the following steps:
(1) Radix Glycyrrhizae of selected weight portion, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Rhizoma Pinelliae, Radix Rehmanniae, Rhizoma Cyperi (processed with vinegar), Rhizoma Polygonati Odorati, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Radix Ophiopogonis and the Radix Astragali are taken, extracting in water 1��5 time, with the gross weight of the mixture of Radix Glycyrrhizae, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Rhizoma Pinelliae, Radix Rehmanniae, Rhizoma Cyperi (processed with vinegar), Rhizoma Polygonati Odorati, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Radix Ophiopogonis and the Radix Astragali for benchmark, the water extraction of addition 4��16 weight times amount 0.5��10 hour every time, filter, merging filtrate, stand, concentration, obtain clear paste, standby;
(2) donkey skin of selected weight portion is taken, soak at least 48 hours, the reflux, extract, that adds water extracting in water 1��5 time, add the water extraction 0.5��20 hour of 2��15 weight times amount every time, filter, merging filtrate, adds appropriate Alumen, stirring, mix homogeneously, stand, concentration, obtains concentrated solution, standby;
(3) described concentrated solution is filtered, be heated to reflux, be subsequently adding described clear paste, mix, stir, to obtain final product.
6. the preparation method of Chinese medicine composition according to claim 5, it is characterised in that comprise the following steps:
(1) Radix Glycyrrhizae of selected weight portion is taken, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Rhizoma Pinelliae, Radix Rehmanniae, Rhizoma Cyperi (processed with vinegar), Rhizoma Polygonati Odorati, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Radix Ophiopogonis and the Radix Astragali, extracting in water 3 times, with Radix Glycyrrhizae, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Rhizoma Pinelliae, Radix Rehmanniae, Rhizoma Cyperi (processed with vinegar), Rhizoma Polygonati Odorati, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, the gross weight of the mixture of Radix Ophiopogonis and the Radix Astragali is benchmark, the water extraction of the 1st addition 8��12 weight times amount 1��5 hour, the water extraction of the 2nd addition 6��10 weight times amount 0.5��4 hour, the water extraction of the 3rd addition 6��10 weight times amount 0.5��2 hour, filter, merging filtrate, stand, it is 1.15-1.40 that supernatant A is concentrated at 50 DEG C relative density, obtain clear paste, standby,
(2) take the donkey skin of selected weight portion, soak at least 48 hours, the reflux, extract, that adds water 2 times, the water extraction of the 1st addition 6��10 weight times amount 12��18 hours, the water extraction of the 2nd addition 6��10 weight times amount 10��16 hours, filters, merging filtrate, add appropriate Alumen, stirring, mix homogeneously, stand, and being concentrated at 50 DEG C by supernatant B relative density is 1.03-1.12, obtain concentrated solution, standby;
(3) described concentrated solution is filtered, be heated to reflux, be subsequently adding described clear paste, mix, stir, to obtain final product.
7. the preparation method of Chinese medicine composition according to claim 6, it is characterised in that comprise the following steps:
(1) Radix Glycyrrhizae of selected weight portion is taken, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Rhizoma Pinelliae, Radix Rehmanniae, Rhizoma Cyperi (processed with vinegar), Rhizoma Polygonati Odorati, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Radix Ophiopogonis and the Radix Astragali, extracting in water 3 times, with Radix Glycyrrhizae, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Rhizoma Pinelliae, Radix Rehmanniae, Rhizoma Cyperi (processed with vinegar), Rhizoma Polygonati Odorati, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, the gross weight of the mixture of Radix Ophiopogonis and the Radix Astragali is benchmark, the water extraction of the 1st addition 9��11 weight times amount 2��4 hours, the water extraction of the 2nd addition 7��9 weight times amount 1��3 hour, the water extraction of the 3rd addition 7��9 weight times amount 0.5��1.5 hour, filter, merging filtrate, stand, it is 1.15-1.40 that supernatant A is concentrated at 50 DEG C relative density, obtain clear paste, standby,
(2) take the donkey skin of selected weight portion, soak at least 48 hours, the reflux, extract, that adds water 2 times, the water extraction of the 1st addition 7��9 weight times amount 14��16 hours, the water extraction of the 2nd addition 7��9 weight times amount 12��14 hours, filters, merging filtrate, add appropriate Alumen, stirring, mix homogeneously, stand, and being concentrated at 50 DEG C by supernatant B relative density is 1.03-1.12, obtain concentrated solution, standby;
(3) described concentrated solution is filtered, be heated to reflux, be subsequently adding described clear paste, mix, stir, to obtain final product.
8. the preparation method of Chinese medicine composition according to claim 7, it is characterised in that comprise the following steps:
(1) Radix Glycyrrhizae of selected weight portion is taken, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Rhizoma Pinelliae, Radix Rehmanniae, Rhizoma Cyperi (processed with vinegar), Rhizoma Polygonati Odorati, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Radix Ophiopogonis and the Radix Astragali, extracting in water 3 times, with Radix Glycyrrhizae, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Rhizoma Pinelliae, Radix Rehmanniae, Rhizoma Cyperi (processed with vinegar), Rhizoma Polygonati Odorati, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, the gross weight of the mixture of Radix Ophiopogonis and the Radix Astragali is benchmark, the water extraction of the 1st addition 10 weight times amount 3 hours, the water extraction of the 2nd addition 8 weight times amount 2 hours, the water extraction of the 3rd addition 8 weight times amount 1 hour, filter, merging filtrate, stand, it is 1.35 that supernatant A is concentrated at 50 DEG C relative density, obtain clear paste, standby,
(2) take the donkey skin of selected weight portion, soak at least 48 hours, the reflux, extract, that adds water 2 times, the water extraction of the 1st addition 8 weight times amount 15 hours, the water extraction of the 2nd addition 8 weight times amount 13 hours, filters, merging filtrate, add appropriate Alumen, stirring, mix homogeneously, stand, and being concentrated at 50 DEG C by supernatant B relative density is 1.07-1.09, obtain concentrated solution, standby;
(3) described concentrated solution is filtered, be heated to reflux, be subsequently adding described clear paste, mix, stir, to obtain final product.
9. include the preparation of the Chinese medicine composition described in any one of claim 1-3 or include the preparation of the Chinese medicine composition that the preparation method described in any one of claim 4-8 prepares, it is characterised in that
Described Chinese medicine composition adds customary adjuvant, conventionally technique, makes acceptable tablet, capsule, powder, mixture, pill, colloid, unguentum, granule, solution, syrup, suppository, aerosol or injection clinically.
10. the preparation of the Chinese medicine composition described in the Chinese medicine composition described in any one of claim 1-3, the preparation method described in any one of claim 4-8 prepare Chinese medicine composition or claim 9 has the application in the medicine of anti-anemia action effect in preparation.
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| CN116870096A (en) * | 2023-08-04 | 2023-10-13 | 北京同仁堂科技发展股份有限公司 | Application of tranquillizing and brain tonic liquid in preparing medicine for treating or preventing depression |
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