CN105616823A - External Chinese herba preparation for treating anal fistula and preparing method and application of external Chinese herba preparation - Google Patents

External Chinese herba preparation for treating anal fistula and preparing method and application of external Chinese herba preparation Download PDF

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CN105616823A
CN105616823A CN201610141830.5A CN201610141830A CN105616823A CN 105616823 A CN105616823 A CN 105616823A CN 201610141830 A CN201610141830 A CN 201610141830A CN 105616823 A CN105616823 A CN 105616823A
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anal fistula
root
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traditional chinese
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吴申龙
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Abstract

The invention discloses an external Chinese herba preparation for treating anal fistula and a preparing method and application of the external Chinese herba preparation. The external Chinese herba preparation for treating anal fistula is prepared from, by weight, 20-30 parts of flos carthami, 20-30 parts of radix ranunculi ternati, 10-20 parts of endothelium corneum gigeriae galli, 10-20 parts of ginkgo biloba, 10-20 parts of girald jasmine roots, 6-10 parts of folium artemisiae argyi, 10-14 parts of chrysanthemum buds, 8-12 parts of tea leaves, 8-12 parts of common diuranthera roots, 6-10 parts of all-grass of Pilea sinocrassifolia C.J.Chen [Pilea crassifolia Hance], 6-10 parts of turtle shells, 5-9 parts of figs, 5-9 parts of myrrh, 3-5 parts of borneol, 3-5 parts of medicine terminalia fruits, 2-4 parts of pearl powder, 2-4 parts of resina draconis, 1-3 parts of calculus bovis, 1-3 parts of flos magnoliae and 0.5-1.5 parts of musk. The purpose of treating anal fistula is achieved through transdermal absorption of medicine, the symptoms such as dampness, itching, eczema, heating, shivering and lacking in strength, caused by anal fistula, of the regio analis are effectively relieved, anal fistula is treated radically, the external Chinese herba preparation directly acts on the skin and is free of toxic or side effects, and a new option is provided for clinically treating anal fistula and relieving various symptoms caused by anal fistula.

Description

A kind of traditional Chinese medicine for outer use treating anal fistula and its production and use
Technical field
The present invention relates to medical applications technical field, specifically a kind of traditional Chinese medicine for outer use treating anal fistula and its production and use.
Background technology
Anal fistula, also known as anus leakage, is the abbreviation of anal orifice and rectal intestine fistula. Dripping urine endlessly its main clinic symptoms of anal fistula repeatedly outwards suppurates or purulence blood from the open sore part skin around the rectum, even flows out ight soil, and the cognition that anal fistula patient has oneself personal is with painful. Once anal fistula is formed, the chance of self-healing is few, after fistula is complicated, brings many troubles and certain hazardness. Affecting working and learning, can make in poor health becoming thin, lassitude in the course of time, resistance against diseases declines, and anaemia occurs, and outbreak is also all the more frequent, forms the vicious cycle relation of reciprocal causation.
Anal fistula is had a lot of Researching and practicing by Chinese Medicine, " doctor's door mend to be cured method mend want hemorrhoid " in have cloud: " with the passing of time difficulty is held back or is more burst again more than the moon; often sees and thus becomes leakage person for downward flow of damp-heat large intestine; first send out pimple little from anus; purulence of gradually bursting greatly, interior logical large intestine; take advantage of from the beginning of, take heat-clearing inner dissipation, number subsides can be healed. If first having coughed leakage person, do not control ". Think: occuring as around anal orifice and rectal intestine after ulcer is burst of anal fistula is not closed up for a long time, and damp and hot residual poison to the greatest extent, does not pent up and do not fall apart, caused by hematogenous blockage, or because of spleen, lung, kidney three the moon loss, or become because anal fissure damage infection. Traditional Chinese medicine is more to the classification of anal fistula, has many pictutes. Say as in " behind surgery great achievement bottom " ": leakage has eight: kidney Yu is leaked, raw SHENYU acupoint. The melon stalks of rice, wheat, etc. leaks, and shape is such as water outlet watermelon stalks of rice, wheat, etc. and so on. The scrotum leaks, and leakage pipe leads in capsule also. Fistula around the anus, for its pipe coils in anus also. Flexing is leaked, for its pipe song is bent not straight, it is difficult to prescribe medicine is the end of to also. Alter stern leakage, honeycomb leakage, if the two hard looks of disease skin are black, must in have and heavily manage, though to hang line, wearing successively and control, be eventful rather. Logical intestinal fistula, only leaks with this and is easy to dig up the roots with extension line. "
In treatment anal orifice and rectal intestine ulcer, according in its pathogenic process from the beginning of, become purulence, burst after three phases, respectively to disappear, to hold in the palm, to mend three methods treatments: 1. elimination: this is with the medicine dissipated, make from the beginning of crissum ulcer and inflammatory external hemorrhoid etc. dissipated, from the hardship of routed purulence He incision. This method is applicable to not become the diseases such as the crissum ulcer of purulence, inflammatory external hemorrhoid, thrombus external piles and anal fissure. Methods for the treatment of has table heresy person to induce sweat, inner real person should Tongli, the hot poison person of penting up should be clearing heat and detoxicating, cold-evil condensation person Ying Wentong, and stagnation of the circulation of vital energy person wants promoting the circulation of qi, and blood stasis of blood person wants promoting blood circulation and removing blood stasis etc. All persons that do not become purulence, it is possible to inside disappear, though can not in disappear, it is possible to moving and deeply go out shallow, it is heavily light for turning. 2. holding in the palm method: be with the medicine of benefiting vital QI and blood, reinforcing body resistance, holder poison leaks, in order to avoid pathogenic poison invading toward interior. This method is applicable to perianal abscess mid-term, deficiency of vital QI, and poison is evil to be contained partially, and poison can not be ask to pass through inside, and crissum ulcer profile is flat collapses, and root pin is careless and sloppy, difficult difficult rotten asthenic symptoms of bursting. As poison gas is contained and the healthy tendency person of not declining, the medicine of available purulence, short its releases purulence poison early, and the swollen pain that disappears subtracts, in order to avoid purulent toxin involving the surrounding tissue, causes future trouble. 3. reinforcing method: be with the medicine of help, recovers healthy tendency, helps to foster affected part new life, the open sore part, fistula mouth are healed early. All asthenia of qi and blood weak persons, suitable invigorating QI and blood, all weakness of the spleen and the stomach persons, should manage spleen and stomach, and all deficiency of the liver and kindey persons, should mend nourishing the liver and kidney etc.
Traditional Chinese medical science Nei Zhi anal fistula is summed up to get up roughly to have ten big ways: 1) clearing heat and cooling blood: choosing side's acupuncture and moxibusion, Pilulae Fructus Sophorae add and subtract treatment; 2) clearing heat and promoting diuresis: conventional Bi moss excreting dampness soup, Decoction of Gentiana for Purging the Liver-fire add and subtract treatment; 3) clearing heat and detoxicating: conventional Rhizoma Coptidis toxic materials clearing away decoction, Xian fang Huoming Yin add and subtract treatment; 4) purge heat logical internal organs: conventional DACHENGQI TANG, spleen are about Fructus Cannabis Bolus and add and subtract treatment; 5) nourishing YIN to relieve dryness: conventional relaxing bowel, five kernel soup or Zengye Tang treatment: 6) benefiting vital QI and blood: conventional decoction of ten powerful tonics, BAZHEN TANG treatment; 7) warming Yang, enlivening spleen: conventional loess Tonga subtracts treatment; 8) promoting blood circulation to remove blood stasis: conventional TAOHONG SIWU TANG adds and subtracts treatment. 9) invigorating the spleen and replenishing QI: conventional Buzhongyiqi Tang treatment. 10), nourishing Yin and clearing heat: conventional sweet wormwood herb and turtle shell Tonga subtracts treatment.
Modern medicine is thought: the cause of disease of anal fistula mainly bacteriological infection. Bacterium is based on intestinal bacteria, tubercule bacillus, Bacillus proteus. The position that bacterium is invaded is anus crypts, anal gland conduit and anal gland body. Anal gland infects, suppurates, and forms perianal abscess, naturally broken routed. Or underwent operative cuts after apocenosis, abscess wall by reticular tissue and granulation tissue hyperplasia, be narrowed to tubulose, outer mouth reduces, and interior mouth continues to infect, can not self-healing, anal fistula. After abscess breaks routed or incision and drainage, Chang Buneng cures.
At present, the methods for the treatment of of anal fistula generally has the skill in using a kitchen knife in cookery, cautery therapy, injection, thread-drawing therapy, ligation method etc. Owing to the about function of drawing together of anus is completed jointly by anus external sphincter, anal sphincter muscle and musculus levator ani. And anus external sphincter is divided into three layers, i.e. anus external sphincter subcutaneous layer, anus external sphincter shallow-layer and anus external sphincter deep layer. So cutting off external sphincter subcutaneous layer and shallow-layer, the row that generally can not affect people is just. If but cut off anus external sphincter deep layer, and the puborectalis of musculus levator ani and internal sphincter, slack anus will be made, lose the control to anus, the adverse consequences such as cause that scoracratia, rectum are deviate from. And high-order anal fistula more than high-order anal fistula, particularly musculus levator ani, not cutting off musculus levator ani is then difficult to remove focus, and anal fistula is thoroughly cured. Therefore, it is very thorny and difficult for the operative treatment of high-order anal fistula and Complex Anal Fistula.
In view of at present to the traditional Chinese medical science oral drug therapy of anal fistula, not only effect is not remarkable, and side effect is big; Use antibiotic in a large number, can only alleviate and can not effect a radical cure; Not only program is complicated for operative treatment, and patient is painful, hip bath after art, changes dressings until time-consuming taking a lot of work of healing, and also can cause and cut off row that external sphincter the affects people problem such as just.
Summary of the invention
It is an object of the invention to provide a kind of traditional Chinese medicine for outer use treating anal fistula and its production and use.
For achieving the above object, the present invention provides following technical scheme:
Treat a traditional Chinese medicine for outer use for anal fistula, it is made up of the raw material of following weight part: safflower 20-30 part, Root of Catclaw Buttercup 20-30 part, Membrane of Chicken Gizzard 10-20 part, ginkgo 10-20 part, an aromatic plant metioned in ancient books skin 10-20 part, tarragon 6-10 part, chrysanthemum rice 10-14 part, tealeaves 8-12 part, Root of Common Diuranthera 8-12 part, stone Yuan alizarin 6-10 part, turtle shell 6-10 part, Fructus Fici 5-9 part, myrrh 5-9 part, borneol 3-5 part, terminalia flesh 3-5 part, pearl powder 2-4 part, dragon's blood 2-4 part, cow-bezoar 1-3 part, flower bud of lily magnolia 1-3 part, Moschus 0.5-1.5 part.
As the scheme that the present invention is further: the traditional Chinese medicine for outer use of described treatment anal fistula, it is made up of the raw material of following weight part: safflower 22-28 part, Root of Catclaw Buttercup 22-28 part, Membrane of Chicken Gizzard 12-18 part, ginkgo 12-18 part, an aromatic plant metioned in ancient books skin 12-18 part, tarragon 7-9 part, chrysanthemum rice 11-13 part, tealeaves 9-11 part, Root of Common Diuranthera 9-11 part, the alizarin 7-9 part of stone Yuan, turtle shell 7-9 part, Fructus Fici 6-8 part, myrrh 6-8 part, borneol 3.5-4.5 part, terminalia flesh 3.5-4.5 part, pearl powder 2.5-3.5 part, dragon's blood 2.5-3.5 part, cow-bezoar 1.5-2.5 part, flower bud of lily magnolia 1.5-2.5 part, Moschus 0.8-1.2 part.
As the scheme that the present invention is further: the traditional Chinese medicine for outer use of described treatment anal fistula, is made up of the raw material of following weight part: 25 parts, safflower, Root of Catclaw Buttercup 25 parts, Membrane of Chicken Gizzard 15 parts, ginkgo 15 parts, an aromatic plant metioned in ancient books skin 15 parts, tarragon 8 parts, 12 parts, chrysanthemum rice, tealeaves 10 parts, Root of Common Diuranthera 10 parts, alizarin 8 parts of stone Yuan, turtle shell 8 parts, Fructus Fici 7 parts, myrrh 7 parts, borneol 4 parts, terminalia flesh 4 parts, pearl powder 3 parts, dragon's blood 3 parts, cow-bezoar 2 parts, the flower bud of lily magnolia 2 parts, 1 part, Moschus.
The preparation method of the traditional Chinese medicine for outer use of described treatment anal fistula, concrete steps are as follows:
(1) each raw material is taken according to weight part;
(2) Membrane of Chicken Gizzard, tarragon, chrysanthemum rice, stone Yuan madder, turtle shell, Fructus Fici, borneol, terminalia flesh, pearl powder, dragon's blood, Moschus being placed in vacuum drying oven and cure 2-4h in 40-60 DEG C, after letting cool, all medicinal materials roll into thick end altogether;
(3) by safflower, Root of Catclaw Buttercup, an aromatic plant metioned in ancient books skin, tealeaves, Root of Common Diuranthera, ginkgo, myrrh, the flower bud of lily magnolia, cow-bezoar, putting into boil medicine utensil marmite, crock or aluminum pot, add clean water, amount of water, with dipped powder 3-5cm, first soaks 20-40min before decocting;
(4) the thick end that step (2) obtains mixed even, refluxing extraction twice, add the water of 300-400 part every time, and be heated to 90-100 DEG C, each refluxing extraction 3-4h, filter, extract liquid, merge twice liquid;
(5) by the starting material after soaking in step (3) with boiling formulation extract twice, first time adds the water boil 2-4h of medicine 6-8 times of weight, and second time adds water boil 1-3h hour of medicine 5-7 times of weight, merges liquid, filtering and standing 20-24h;
(6) liquid that step (4) and step (5) obtained merges, concentrate to relative density be the clear cream of 1.10-1.15,60 DEG C, adding ethanol to alcohol content is 65%, leave standstill 22-24h, filter, reclaim ethanol, concentrated, drying obtain extract powder;
(7) in extract powder, add the lanolin of 20-30 part and the Vaseline of 80-100 part, grind well, obtain external preparation finished product.
As the present invention's further scheme: the application of described traditional Chinese medicine for outer use in preparation treatment anal fistula medicine.
Compared with prior art, the invention has the beneficial effects as follows:
The present invention is by the Transdermal absorption of medicine, reach the object for the treatment of anal fistula, symptoms such as effectively alleviating anus portion humidity, itch, eczema that anal fistula causes, generate heat, shiver, be weak, fundamentally treat anal fistula, directly act on skin, not having toxic side effect, be clinical treatment anal fistula, the various symptoms that alleviation anal fistula causes provide one and newly select.
Embodiment
Below in conjunction with embodiment, the technical scheme of this patent is described in more detail.
Embodiment 1
Treat a traditional Chinese medicine for outer use for anal fistula, it is made up of the raw material of following weight part: 20 parts, safflower, Root of Catclaw Buttercup 20 parts, Membrane of Chicken Gizzard 10 parts, ginkgo 10 parts, an aromatic plant metioned in ancient books skin 10 parts, tarragon 6 parts, 10 parts, chrysanthemum rice, tealeaves 8 parts, Root of Common Diuranthera 8 parts, alizarin 6 parts of stone Yuan, turtle shell 6 parts, Fructus Fici 5 parts, myrrh 5 parts, borneol 3 parts, terminalia flesh 3 parts, pearl powder 2 parts, dragon's blood 2 parts, cow-bezoar 1 part, the flower bud of lily magnolia 1 part, 0.5 part, Moschus.
The preparation method of the traditional Chinese medicine for outer use of described treatment anal fistula, concrete steps are as follows:
(1) each raw material is taken according to weight part;
(2) Membrane of Chicken Gizzard, tarragon, chrysanthemum rice, stone Yuan madder, turtle shell, Fructus Fici, borneol, terminalia flesh, pearl powder, dragon's blood, Moschus being placed in vacuum drying oven and cure 2h in 40 DEG C, after letting cool, all medicinal materials roll into thick end altogether;
(3) by safflower, Root of Catclaw Buttercup, an aromatic plant metioned in ancient books skin, tealeaves, Root of Common Diuranthera, ginkgo, myrrh, the flower bud of lily magnolia, cow-bezoar, putting into boil medicine utensil marmite, crock or aluminum pot, add clean water, amount of water, with dipped powder 3cm, first soaks 20min before decocting;
(4) the thick end that step (2) obtains mixed even, refluxing extraction twice, the water every time adding 300 part, and it is heated to 90 DEG C, each refluxing extraction 3h, filter, extract liquid, merge twice liquid;
(5) by the starting material after soaking in step (3) with boiling formulation extract twice, first time adds the water boil 2h of medicine 6 times of weight, and second time adds water boil 1h hour of medicine 5 times of weight, merges liquid, filtering and standing 20h;
(6) liquid that step (4) and step (5) obtained merges, and concentrating to relative density is the clear cream of 1.10,60 DEG C, and adding ethanol to alcohol content is 65%, leaves standstill 22h, filters, reclaim ethanol, concentrated, drying obtain extract powder;
(7) in extract powder, add the lanolin of 20 parts and the Vaseline of 80 parts, grind well, obtain external preparation finished product.
Embodiment 2
Treat a traditional Chinese medicine for outer use for anal fistula, it is made up of the raw material of following weight part: 22 parts, safflower, Root of Catclaw Buttercup 22 parts, Membrane of Chicken Gizzard 12 parts, ginkgo 12 parts, an aromatic plant metioned in ancient books skin 12 parts, tarragon 7 parts, 11 parts, chrysanthemum rice, tealeaves 9 parts, Root of Common Diuranthera 9 parts, alizarin 7 parts of stone Yuan, turtle shell 7 parts, Fructus Fici 6 parts, myrrh 6 parts, borneol 3.5 parts, terminalia flesh 3.5 parts, pearl powder 2.5 parts, dragon's blood 2.5 parts, cow-bezoar 1.5 parts, the flower bud of lily magnolia 1.5 parts, 0.8 part, Moschus.
The preparation method of the traditional Chinese medicine for outer use of described treatment anal fistula, concrete steps are as follows:
(1) each raw material is taken according to weight part;
(2) Membrane of Chicken Gizzard, tarragon, chrysanthemum rice, stone Yuan madder, turtle shell, Fructus Fici, borneol, terminalia flesh, pearl powder, dragon's blood, Moschus being placed in vacuum drying oven and cure 2.5h in 45 DEG C, after letting cool, all medicinal materials roll into thick end altogether;
(3) by safflower, Root of Catclaw Buttercup, an aromatic plant metioned in ancient books skin, tealeaves, Root of Common Diuranthera, ginkgo, myrrh, the flower bud of lily magnolia, cow-bezoar, putting into boil medicine utensil marmite, crock or aluminum pot, add clean water, amount of water, with dipped powder 3.5cm, first soaks 25min before decocting;
(4) the thick end that step (2) obtains mixed even, refluxing extraction twice, the water every time adding 320 part, and it is heated to 92 DEG C, each refluxing extraction 3.2h, filter, extract liquid, merge twice liquid;
(5) by the starting material after soaking in step (3) with boiling formulation extract twice, first time adds the water boil 2.5h of medicine 6.5 times of weight, and second time adds water boil 1.5h hour of medicine 5.5 times of weight, merges liquid, filtering and standing 21h;
(6) liquid that step (4) and step (5) obtained merges, concentrate to relative density be the clear cream of 1.11,60 DEG C, adding ethanol to alcohol content is 65%, leave standstill 22.5h, filter, reclaim ethanol, concentrated, drying obtain extract powder;
(7) in extract powder, add the lanolin of 22 parts and the Vaseline of 85 parts, grind well, obtain external preparation finished product.
Embodiment 3
Treat a traditional Chinese medicine for outer use for anal fistula, it is made up of the raw material of following weight part: 25 parts, safflower, Root of Catclaw Buttercup 25 parts, Membrane of Chicken Gizzard 15 parts, ginkgo 15 parts, an aromatic plant metioned in ancient books skin 15 parts, tarragon 8 parts, 12 parts, chrysanthemum rice, tealeaves 10 parts, Root of Common Diuranthera 10 parts, alizarin 8 parts of stone Yuan, turtle shell 8 parts, Fructus Fici 7 parts, myrrh 7 parts, borneol 4 parts, terminalia flesh 4 parts, pearl powder 3 parts, dragon's blood 3 parts, cow-bezoar 2 parts, the flower bud of lily magnolia 2 parts, 1 part, Moschus.
The preparation method of the traditional Chinese medicine for outer use of described treatment anal fistula, concrete steps are as follows:
(1) each raw material is taken according to weight part;
(2) Membrane of Chicken Gizzard, tarragon, chrysanthemum rice, stone Yuan madder, turtle shell, Fructus Fici, borneol, terminalia flesh, pearl powder, dragon's blood, Moschus being placed in vacuum drying oven and cure 3h in 50 DEG C, after letting cool, all medicinal materials roll into thick end altogether;
(3) by safflower, Root of Catclaw Buttercup, an aromatic plant metioned in ancient books skin, tealeaves, Root of Common Diuranthera, ginkgo, myrrh, the flower bud of lily magnolia, cow-bezoar, putting into boil medicine utensil marmite, crock or aluminum pot, add clean water, amount of water, with dipped powder 4cm, first soaks 30min before decocting;
(4) the thick end that step (2) obtains mixed even, refluxing extraction twice, the water every time adding 350 part, and it is heated to 95 DEG C, each refluxing extraction 3.5h, filter, extract liquid, merge twice liquid;
(5) by the starting material after soaking in step (3) with boiling formulation extract twice, first time adds the water boil 3h of medicine 7 times of weight, and second time adds water boil 2h hour of medicine 6 times of weight, merges liquid, filtering and standing 22h;
(6) liquid that step (4) and step (5) obtained merges, and concentrating to relative density is the clear cream of 1.13,60 DEG C, and adding ethanol to alcohol content is 65%, leaves standstill 23h, filters, reclaim ethanol, concentrated, drying obtain extract powder;
(7) in extract powder, add the lanolin of 25 parts and the Vaseline of 90 parts, grind well, obtain external preparation finished product.
Embodiment 4
Treat a traditional Chinese medicine for outer use for anal fistula, it is made up of the raw material of following weight part: 28 parts, safflower, Root of Catclaw Buttercup 28 parts, Membrane of Chicken Gizzard 18 parts, ginkgo 18 parts, an aromatic plant metioned in ancient books skin 18 parts, tarragon 9 parts, 13 parts, chrysanthemum rice, tealeaves 11 parts, Root of Common Diuranthera 11 parts, alizarin 9 parts of stone Yuan, turtle shell 9 parts, Fructus Fici 8 parts, myrrh 8 parts, borneol 4.5 parts, terminalia flesh 4.5 parts, pearl powder 3.5 parts, dragon's blood 3.5 parts, cow-bezoar 2.5 parts, the flower bud of lily magnolia 2.5 parts, 1.2 parts, Moschus.
The preparation method of the traditional Chinese medicine for outer use of described treatment anal fistula, concrete steps are as follows:
(1) each raw material is taken according to weight part;
(2) Membrane of Chicken Gizzard, tarragon, chrysanthemum rice, stone Yuan madder, turtle shell, Fructus Fici, borneol, terminalia flesh, pearl powder, dragon's blood, Moschus being placed in vacuum drying oven and cure 3.5h in 55 DEG C, after letting cool, all medicinal materials roll into thick end altogether;
(3) by safflower, Root of Catclaw Buttercup, an aromatic plant metioned in ancient books skin, tealeaves, Root of Common Diuranthera, ginkgo, myrrh, the flower bud of lily magnolia, cow-bezoar, putting into boil medicine utensil marmite, crock or aluminum pot, add clean water, amount of water, with dipped powder 4.5cm, first soaks 35min before decocting;
(4) the thick end that step (2) obtains mixed even, refluxing extraction twice, the water every time adding 380 part, and it is heated to 98 DEG C, each refluxing extraction 3.8h, filter, extract liquid, merge twice liquid;
(5) by the starting material after soaking in step (3) with boiling formulation extract twice, first time adds the water boil 3.5h of medicine 7.5 times of weight, and second time adds water boil 2.5h hour of medicine 6.5 times of weight, merges liquid, filtering and standing 23h;
(6) liquid that step (4) and step (5) obtained merges, concentrate to relative density be the clear cream of 1.14,60 DEG C, adding ethanol to alcohol content is 65%, leave standstill 23.5h, filter, reclaim ethanol, concentrated, drying obtain extract powder;
(7) in extract powder, add the lanolin of 28 parts and the Vaseline of 95 parts, grind well, obtain external preparation finished product.
Embodiment 5
Treat a traditional Chinese medicine for outer use for anal fistula, it is made up of the raw material of following weight part: 30 parts, safflower, Root of Catclaw Buttercup 30 parts, Membrane of Chicken Gizzard 20 parts, ginkgo 20 parts, an aromatic plant metioned in ancient books skin 20 parts, tarragon 10 parts, 14 parts, chrysanthemum rice, tealeaves 12 parts, Root of Common Diuranthera 12 parts, alizarin 10 parts of stone Yuan, turtle shell 10 parts, Fructus Fici 9 parts, myrrh 9 parts, borneol 5 parts, terminalia flesh 5 parts, pearl powder 4 parts, dragon's blood 4 parts, cow-bezoar 3 parts, the flower bud of lily magnolia 3 parts, Moschus 0.1.5 part.
The preparation method of the traditional Chinese medicine for outer use of described treatment anal fistula, concrete steps are as follows:
(1) each raw material is taken according to weight part;
(2) Membrane of Chicken Gizzard, tarragon, chrysanthemum rice, stone Yuan madder, turtle shell, Fructus Fici, borneol, terminalia flesh, pearl powder, dragon's blood, Moschus being placed in vacuum drying oven and cure 4h in 60 DEG C, after letting cool, all medicinal materials roll into thick end altogether;
(3) by safflower, Root of Catclaw Buttercup, an aromatic plant metioned in ancient books skin, tealeaves, Root of Common Diuranthera, ginkgo, myrrh, the flower bud of lily magnolia, cow-bezoar, putting into boil medicine utensil marmite, crock or aluminum pot, add clean water, amount of water, with dipped powder 5cm, first soaks 40min before decocting;
(4) the thick end that step (2) obtains mixed even, refluxing extraction twice, the water every time adding 400 part, and it is heated to 100 DEG C, each refluxing extraction 4h, filter, extract liquid, merge twice liquid;
(5) by the starting material after soaking in step (3) with boiling formulation extract twice, first time adds the water boil 4h of medicine 8 times of weight, and second time adds water boil 3h hour of medicine 7 times of weight, merges liquid, filtering and standing 24h;
(6) liquid that step (4) and step (5) obtained merges, and concentrating to relative density is the clear cream of 1.15,60 DEG C, and adding ethanol to alcohol content is 65%, leaves standstill 24h, filters, reclaim ethanol, concentrated, drying obtain extract powder;
(7) in extract powder, add the lanolin of 30 parts and the Vaseline of 100 parts, grind well, obtain external preparation finished product.
Comparative example 1
Treat a traditional Chinese medicine for outer use for anal fistula, it is made up of the raw material of following weight part: 22 parts, safflower, Root of Catclaw Buttercup 22 parts, Membrane of Chicken Gizzard 12 parts, ginkgo 12 parts, an aromatic plant metioned in ancient books skin 12 parts, tarragon 7 parts, 11 parts, chrysanthemum rice, tealeaves 9 parts, Root of Common Diuranthera 9 parts, alizarin 7 parts of stone Yuan, Fructus Fici 6 parts, myrrh 6 parts, borneol 3.5 parts, terminalia flesh 3.5 parts, pearl powder 2.5 parts, dragon's blood 2.5 parts, cow-bezoar 1.5 parts, the flower bud of lily magnolia 1.5 parts, 0.8 part, Moschus.
The preparation method of the traditional Chinese medicine for outer use of described treatment anal fistula, concrete steps are as follows:
(1) each raw material is taken according to weight part;
(2) Membrane of Chicken Gizzard, tarragon, chrysanthemum rice, stone Yuan madder, Fructus Fici, borneol, terminalia flesh, pearl powder, dragon's blood, Moschus being placed in vacuum drying oven and cure 2.5h in 45 DEG C, after letting cool, all medicinal materials roll into thick end altogether;
(3) by safflower, Root of Catclaw Buttercup, an aromatic plant metioned in ancient books skin, tealeaves, Root of Common Diuranthera, ginkgo, myrrh, the flower bud of lily magnolia, cow-bezoar, putting into boil medicine utensil marmite, crock or aluminum pot, add clean water, amount of water, with dipped powder 3.5cm, first soaks 25min before decocting;
(4) the thick end that step (2) obtains mixed even, refluxing extraction twice, the water every time adding 320 part, and it is heated to 92 DEG C, each refluxing extraction 3.2h, filter, extract liquid, merge twice liquid;
(5) by the starting material after soaking in step (3) with boiling formulation extract twice, first time adds the water boil 2.5h of medicine 6.5 times of weight, and second time adds water boil 1.5h hour of medicine 5.5 times of weight, merges liquid, filtering and standing 21h;
(6) liquid that step (4) and step (5) obtained merges, concentrate to relative density be the clear cream of 1.11,60 DEG C, adding ethanol to alcohol content is 65%, leave standstill 22.5h, filter, reclaim ethanol, concentrated, drying obtain extract powder;
(7) in extract powder, add the lanolin of 22 parts and the Vaseline of 85 parts, grind well, obtain external preparation finished product.
Comparative example 2
Treat a traditional Chinese medicine for outer use for anal fistula, it is made up of the raw material of following weight part: 28 parts, safflower, Root of Catclaw Buttercup 28 parts, Membrane of Chicken Gizzard 18 parts, ginkgo 18 parts, an aromatic plant metioned in ancient books skin 18 parts, tarragon 9 parts, 13 parts, chrysanthemum rice, tealeaves 11 parts, Root of Common Diuranthera 11 parts, alizarin 9 parts of stone Yuan, turtle shell 9 parts, Fructus Fici 8 parts, myrrh 8 parts, borneol 4.5 parts, terminalia flesh 4.5 parts, pearl powder 3.5 parts, dragon's blood 3.5 parts, cow-bezoar 2.5 parts, 1.2 parts, Moschus.
The preparation method of the traditional Chinese medicine for outer use of described treatment anal fistula, concrete steps are as follows:
(1) each raw material is taken according to weight part;
(2) Membrane of Chicken Gizzard, tarragon, chrysanthemum rice, stone Yuan madder, turtle shell, Fructus Fici, borneol, terminalia flesh, pearl powder, dragon's blood, Moschus being placed in vacuum drying oven and cure 3.5h in 55 DEG C, after letting cool, all medicinal materials roll into thick end altogether;
(3) by safflower, Root of Catclaw Buttercup, an aromatic plant metioned in ancient books skin, tealeaves, Root of Common Diuranthera, ginkgo, myrrh, cow-bezoar, putting into boil medicine utensil marmite, crock or aluminum pot, add clean water, amount of water, with dipped powder 4.5cm, first soaks 35min before decocting;
(4) the thick end that step (2) obtains mixed even, refluxing extraction twice, the water every time adding 380 part, and it is heated to 98 DEG C, each refluxing extraction 3.8h, filter, extract liquid, merge twice liquid;
(5) by the starting material after soaking in step (3) with boiling formulation extract twice, first time adds the water boil 3.5h of medicine 7.5 times of weight, and second time adds water boil 2.5h hour of medicine 6.5 times of weight, merges liquid, filtering and standing 23h;
(6) liquid that step (4) and step (5) obtained merges, concentrate to relative density be the clear cream of 1.14,60 DEG C, adding ethanol to alcohol content is 65%, leave standstill 23.5h, filter, reclaim ethanol, concentrated, drying obtain extract powder;
(7) in extract powder, add the lanolin of 28 parts and the Vaseline of 95 parts, grind well, obtain external preparation finished product.
Embodiment 6
Clinical trial
(1) subjects: adopt the present invention to treat 120 example patients altogether, wherein man 80 example, female 40 example; The oldest person 63 years old, the age minimum person 19 years old;
(2) Case definition: all case all meets " traditional Chinese medical science anorectum department disease Case definition " of State Administration of Traditional Chinese Medicine's formulation and the Case definition of whole nation first anus intestines academic conference formulation.
(3) methods for the treatment of: by man 80 example, female 40 example patient is equally divided into five groups, often group man 16 is routine, female 8 is routine, one group, two groups and three groups are test group, one group, two groups and three components do not smear the traditional Chinese medicine for outer use of the treatment anal fistula of the present invention that embodiment 1-embodiment 3 prepares, four groups and five groups is control group, smear comparative example 1 respectively and traditional Chinese medicine for outer use that comparative example 2 prepares for four groups and five groups, using method is coated with traditional Chinese medicine for outer use to put on the skin in affected part, it is 0.6mm that thickness is put in painting on the skin, every day 2 times, sooner or later respectively once, January is a course for the treatment of. After smearing 3 courses for the treatment of continuously, add up the treatment result of five groups, the untoward reaction that during observing treatment, patient occurs simultaneously.
(5) standard is treated
According to Huang Naijian. and China's anorectal disease " M]. Jinan: Shandong science tech publishing house .1996:60 works out efficacy evaluation.
Cure: symptom and sign disappear, and outer mouth heals;
Effective: symptom and sign are improved, and outer mouth does not heal;
Invalid: symptom and sign are all unchanged, or the state of an illness further develops.
(6) treatment result: how taking effect after January after being coated with medicine in patient 120 example case, 6-7 the course for the treatment of cures; Wherein curing 49 examples, effective 53 examples, invalid 18 examples, always have efficiency to reach 85%, and treatment result is as shown in table 1:
Table 1: clinical trial treatment result
As shown in Table 1, the average effective rate adopting the traditional Chinese medicine for outer use of the treatment anal fistula of the present invention to carry out treating reaches 94.4%, the efficiency that has of the pharmaceutical composition that employing comparative example prepares only has 71%, therefore, having synergistic function between the medicine of the present invention, what add traditional Chinese medicine for outer use has efficiency.
Untoward reaction and toxic side effect supervision: by detect patient blood pressure, pulse, whether Nausea and vomiting occurs, dizzy clinical symptom judge untoward reaction. Find that blood pressure and the pulse of 120 example patients are appearance extremely, all in normal range, and Nausea and vomiting, dizzy clinical symptom do not occur. This illustrates that the preparation of the present invention does not have obvious untoward reaction, and then proves that this medicament does not have obvious toxic side effect for human body.
Model case:
(1) bending certain, man, suffers from anus 1 year repeatly, the ill later stage, within one day, goes out twice pus, not only pain but also itch, and suffers untold misery. Arrived the methods such as hospital has carried out atomization respectively, infrared ray radiation, decoction of medicinal ingredients are washed afterwards to treat, but all without effect.
Zou brings into use the Chinese medicine preparation in embodiment 1, the 1st month, rubs once every 3 hours; 2nd month, rub 5 every day; 3rd month starts, rubs 2 every day, within the 5th month, substantially cures, and by 6th month, oneself was through thoroughly curing, and so far without recurrence.
(2) Liu, female, suffers from anal fistula 2 years, often feels that anus place is moistening, underpants are clean, and often swell and discomfort in sensation local, and during walking, pain increases the weight of, perianal itch, and parachromatosis is had difficulty in passing one's motions, and has awareness of defecation sensation not to the utmost.
Liu uses the Chinese medicine preparation in embodiment 2, the 1st month, rubs once every 2 hours; 2nd month, rub 4 every day; 3rd month starts, rubs 2 every day, within the 4th month, substantially cures, and by 6th month, oneself was through thoroughly curing, and so far without recurrence.
(3) hair, man, medical history 3 years, suffers from high-order anal fistula and low position anal fistula. Symptom: with systemic infection symptoms such as generating heat, shiver, be weak; The outer mouth of the fistula of low position anal fistula often flows out a small amount of purulence, courage and uprightness, mucus secretory product, and high-order anal fistula is even has ight soil and gas to discharge; Anus portion is moist, itch, and pain is obviously felt at abscess position. After adopting traditional Chinese powder medicine of the present invention to treat 6 courses for the treatment of, above-mentioned symptom disappears, recovery from illness.
The present invention is by the Transdermal absorption of medicine, reach the object for the treatment of anal fistula, symptoms such as effectively alleviating anus portion humidity, itch, eczema that anal fistula causes, generate heat, shiver, be weak, fundamentally treat anal fistula, directly act on skin, not having toxic side effect, be clinical treatment anal fistula, the various symptoms that alleviation anal fistula causes provide one and newly select.
Above the better embodiment of this patent is explained in detail, but this patent is not limited to above-mentioned enforcement mode, in the ken that one skilled in the relevant art possesses, it is also possible under the prerequisite not departing from this patent objective, make various change.

Claims (5)

1. treat the traditional Chinese medicine for outer use of anal fistula for one kind; it is characterized in that, it is made up of according to the raw material of weight part following: safflower 20-30 part, Root of Catclaw Buttercup 20-30 part, Membrane of Chicken Gizzard 10-20 part, ginkgo 10-20 part, an aromatic plant metioned in ancient books skin 10-20 part, tarragon 6-10 part, chrysanthemum rice 10-14 part, tealeaves 8-12 part, Root of Common Diuranthera 8-12 part, stone Yuan alizarin 6-10 part, turtle shell 6-10 part, Fructus Fici 5-9 part, myrrh 5-9 part, borneol 3-5 part, terminalia flesh 3-5 part, pearl powder 2-4 part, dragon's blood 2-4 part, cow-bezoar 1-3 part, flower bud of lily magnolia 1-3 part, Moschus 0.5-1.5 part.
2. the traditional Chinese medicine for outer use for the treatment of anal fistula according to claim 1, it is characterized in that, it is made up of according to the raw material of weight part following: safflower 22-28 part, Root of Catclaw Buttercup 22-28 part, Membrane of Chicken Gizzard 12-18 part, ginkgo 12-18 part, an aromatic plant metioned in ancient books skin 12-18 part, tarragon 7-9 part, chrysanthemum rice 11-13 part, tealeaves 9-11 part, Root of Common Diuranthera 9-11 part, the alizarin 7-9 part of stone Yuan, turtle shell 7-9 part, Fructus Fici 6-8 part, myrrh 6-8 part, borneol 3.5-4.5 part, terminalia flesh 3.5-4.5 part, pearl powder 2.5-3.5 part, dragon's blood 2.5-3.5 part, cow-bezoar 1.5-2.5 part, flower bud of lily magnolia 1.5-2.5 part, Moschus 0.8-1.2 part.
3. the traditional Chinese medicine for outer use for the treatment of anal fistula according to claim 1; it is characterized in that, it is made up of according to the raw material of weight part following: 25 parts, safflower, Root of Catclaw Buttercup 25 parts, Membrane of Chicken Gizzard 15 parts, ginkgo 15 parts, an aromatic plant metioned in ancient books skin 15 parts, tarragon 8 parts, 12 parts, chrysanthemum rice, tealeaves 10 parts, Root of Common Diuranthera 10 parts, alizarin 8 parts of stone Yuan, turtle shell 8 parts, Fructus Fici 7 parts, myrrh 7 parts, borneol 4 parts, terminalia flesh 4 parts, pearl powder 3 parts, dragon's blood 3 parts, cow-bezoar 2 parts, the flower bud of lily magnolia 2 parts, 1 part, Moschus.
4. one kind as arbitrary in claim 1-3 as described in the preparation method of traditional Chinese medicine for outer use for the treatment of anal fistula, it is characterised in that, concrete steps are as follows:
(1) each raw material is taken according to weight part;
(2) Membrane of Chicken Gizzard, tarragon, chrysanthemum rice, stone Yuan madder, turtle shell, Fructus Fici, borneol, terminalia flesh, pearl powder, dragon's blood, Moschus being placed in vacuum drying oven and cure 2-4h in 40-60 DEG C, after letting cool, all medicinal materials roll into thick end altogether;
(3) by safflower, Root of Catclaw Buttercup, an aromatic plant metioned in ancient books skin, tealeaves, Root of Common Diuranthera, ginkgo, myrrh, the flower bud of lily magnolia, cow-bezoar, putting into boil medicine utensil marmite, crock or aluminum pot, add clean water, amount of water, with dipped powder 3-5cm, first soaks 20-40min before decocting;
(4) the thick end that step (2) obtains mixed even, refluxing extraction twice, add the water of 300-400 part every time, and be heated to 90-100 DEG C, each refluxing extraction 3-4h, filter, extract liquid, merge twice liquid;
(5) by the starting material after soaking in step (3) with boiling formulation extract twice, first time adds the water boil 2-4h of medicine 6-8 times of weight, and second time adds water boil 1-3h hour of medicine 5-7 times of weight, merges liquid, filtering and standing 20-24h;
(6) liquid that step (4) and step (5) obtained merges, and concentrating to relative density is the clear cream of 1.10-1.15,60 DEG C, and adding ethanol to alcohol content is 65%, leaves standstill 22-24h, filters, reclaim ethanol, concentrated, drying obtain extract powder;
(7) in extract powder, add the lanolin of 20-30 part and the Vaseline of 80-100 part, grind well, obtain external preparation finished product.
5. one kind as arbitrary in claim 1-3 as described in traditional Chinese medicine for outer use preparation treatment anal fistula medicine in application.
CN201610141830.5A 2016-03-12 2016-03-12 External Chinese herba preparation for treating anal fistula and preparing method and application of external Chinese herba preparation Withdrawn CN105616823A (en)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1354002A (en) * 2000-11-16 2002-06-19 乌力吉 Medicine for curing gastrointestinal diseases and its production method
CN1552400A (en) * 2003-05-27 2004-12-08 佳木斯市肛肠医院 Anagetic muscle regenerating paste for pile
CN102670849A (en) * 2011-03-18 2012-09-19 浙江科技学院 Anal fistula suppository
CN103520447A (en) * 2013-11-08 2014-01-22 金福树 Externally used ointment suitable for anal fistula after operation
CN104997986A (en) * 2015-07-16 2015-10-28 宋继旭 Traditional Chinese medicine preparation for treating perianal and perirectal abscesses

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1354002A (en) * 2000-11-16 2002-06-19 乌力吉 Medicine for curing gastrointestinal diseases and its production method
CN1552400A (en) * 2003-05-27 2004-12-08 佳木斯市肛肠医院 Anagetic muscle regenerating paste for pile
CN102670849A (en) * 2011-03-18 2012-09-19 浙江科技学院 Anal fistula suppository
CN103520447A (en) * 2013-11-08 2014-01-22 金福树 Externally used ointment suitable for anal fistula after operation
CN104997986A (en) * 2015-07-16 2015-10-28 宋继旭 Traditional Chinese medicine preparation for treating perianal and perirectal abscesses

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