CN105616690A - Drug for treating stomach diseases and preparation method thereof - Google Patents
Drug for treating stomach diseases and preparation method thereof Download PDFInfo
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
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Abstract
The invention discloses a drug for treating stomach diseases. The drug is prepared from, by mass, 170-210 parts of cuttlebones, 40-70 parts of pericarpium citri reticulatae, 80-110 parts of radix aucklandiae, 40-70 parts of rhizoma atractylodis macrocephalae, 170-200 parts of licorice roots, 10-25 parts of berberine hydrochloride and 1.7-3 parts of belladonna extract. The drug can stop bleeding by astringency and relieve spasm and pain, can treat various stomach diseases such as acute or chronic gastritis, a gastric ulcer and a duodenal ulcer, has no incompatibility in all the raw materials, treats both symptoms and root causes, does not damage healthy qi of people, is free of toxic and side effects and can quickly relieve the pain of a patient, the effect is achieved when a less severe patient takes the drug for one time, and the good effect is achieved when a severe patient takes the drug for three to five times.
Description
Technical field
The invention belongs to pure Chinese medicine formula technical field, in particular to a kind of medicine and its preparation method for the treatment of stomach trouble.
Background technology
Stomach trouble has stomach ulcer in doctor trained in Western medicine name of disease. Stomach ulcer refers to mucosa tissue damage and produces ulcer. Stomach ulcer half patient has vomiting, spew very sour, at ordinary times patient often vomit acid water, epigastrium pain is main symptom. Stomach ulcer is apt to occur in lesser gastric curvature place usually, and size may from several millimeters to several centimeters, and may there be the generation of gastritis the edge zone at ulcer place, eats and more may can cause pain, can because not eating and pain relief as duodenal ulcer.
Stomach ulcer, acute with hemorrhage. Time hemorrhage, the chance of occurrence showing as melaena or spitting blood is similar. Acute in short period of time is bled profusely, and can cause giddy, dim eyesight, unable, thirsty, palpitaition, tachycardia, blood pressure drops, faintness because of falling sharply of Q volume of blood, even suffer a shock.
Stomach ulcer, acute, with hemorrhage and perforation. Patient shows unexpected epigastrium severe pain, is diffused into rapidly whole belly, and has spitting blood, has blood in stool and the phenomenon of this type of digestive tract hemorrhage of melaena, also may occur knock-on pain and other intestines and stomaches and constitutional symptom in addition.
Duodenal ulcer, acute, with hemorrhage and perforation. Patient shows unexpected epigastrium severe pain, is diffused into rapidly whole belly, and has spitting blood, has blood in stool and the phenomenon of this type of digestive tract hemorrhage of melaena, also may occur knock-on pain and other intestines and stomaches and constitutional symptom in addition.
The illness of several stomach ulcer is the light and heavy degree difference of disease above. The traditional Chinese medical science is correlated with name of disease: gastric abscess, acid regurgitation, acid regurgitation, noisy, ruffian is full, gastric disorder causing nausea, regurgitation, regurgitation. Pained, bleeding from five sense organs or subcutaneous tissue, spit blood, have blood in stool, bleeding from distant part, rear blood, hide poison, pain in the chest and abdomen, spitting blood.
Stomachache refers to and occurs in the illness of upper abdomen gastral cavilty portion nearly pit of the stomach place pain. Stomachache is clinical common sympton, is more common in acute or chronic gastritis, and taste-blindness rate is sick, stomach neurosis. Also the diseases such as gastric mucosa prolapsus, pancreatitis, cholecystitis and cholelithiasis are seen. This disease is many by anxiety and rage, and edema with the liver involved perverse and unreasonable manner violates stomach or improper diet and overtiredness, caused by impairing the spleen and stomach, has cold-evil to hinder stomach, and stomach hindered by diet, hyperactive liver-QI attacking the stomach, damp and hot middle resistance, and hemostasis stops stomach, stomach-Yin virtual loss, insufficiency of spleen-YANG, syndrome of liver-stomach heat.
The traditional Chinese medical science employs the lenitive pill of " red small stream heart method ", the Yiguan Decoction etc. of " Liuzhou doctor's words ". The dioctahedron that doctor trained in Western medicine uses covers stone (dioctahedral smectite), and sucralfate (stomach is burst peaceful), cisapride, norfloxicin (Norxin), waits the effect all not received. The side effect of western modern medicine is relatively big, is the method cured the symptoms, not the disease. Traditional treatment is single, poor effect.
Summary of the invention
An object of the present invention overcomes the deficiencies in the prior art and provides a kind of medicine treating stomach trouble, acute or chronic gastritis can be treated, the various stomach such as stomach ulcer and duodenal ulcer, in medicine there is not incompatibility in each raw material, and sample treats, do not speak sarcastically healthy tendency, having no side effect, it is possible to solve rapidly patient suffering, the lighter eats once namely effectively, the effect that namely severe one has had for three to five times, can cure in five to seven days.
The two of the object of the present invention are to provide the preparation method of this treatment stomach trouble medicine.
The technical scheme of the present invention is: a kind of medicine treating stomach trouble, comprises the bulk drug of following masses part proportioning: Endoconcha Sepiae 170-210 part, dried orange peel 40-70 part, banksia rose 80-110 part, bighead atractylodes rhizome 40-70 part, Radix Glycyrrhizae 170-200 part, Bererini Hydrochclorium 10-25 part, Semen daturae extractum 1.7-3 part.
The preferred 180-195 part of wherein said Endoconcha Sepiae.
The preferred 50-60 part of wherein said dried orange peel.
The preferred 90-105 part of the wherein said banksia rose.
The preferred 50-60 part of the wherein said bighead atractylodes rhizome.
The preferred 180-195 part of wherein said Radix Glycyrrhizae.
The preferred 15-20 part of wherein said Bererini Hydrochclorium.
The preferred 1.7-2.5 part of wherein said Semen daturae extractum.
Wherein said Endoconcha Sepiae and the ratio of Semen daturae extractum are 80-95:1.
The present invention treats the preparation method of stomach trouble medicine, and it mainly comprises the steps:
(1) getting the bighead atractylodes rhizome, Radix Glycyrrhizae boiling, boiling 3 times, each 1-2 hour, merge decocting liquid, filter, leave standstill 24 hours, get supernatant liquor, be condensed into cream clearly, water content is 15%-20%;
(2) Endoconcha Sepiae, dried orange peel, the banksia rose and Bererini Hydrochclorium are shattered into fine powder respectively, mix, obtained powder mix;
(3) clear cream step (1) produced, adds Semen daturae extractum and powder mix makes softwood, then crosses the sieve granulation of 20-30 order, dry granulating when 60-70 degree;
(4) 0.5% talcum powder is finally added and 0.5% Magnesium Stearate mixes even, tabletted.
The main raw material medicine that the present invention uses is described as follows:
Endoconcha Sepiae: for Sepiidae animal is without the dry inner casing of pin cuttlefish SepiellamaindronideRoehebrune or golden cuttlefish SepiaesculentaHoyle. It is distributed in the ground such as Zhejiang, Fujian, Shandong. There is astringing to arrest bleeding, relieving leukorrhea by astringents, relieving gastric hyperacidity to alleviate stomachache, effect of hygroscopic sore. Being usually used in hematemesis and epistaxis, uterine bleeding is had blood in stool, emission and spermatorrhea, leucorrhea with red and white discharge, stomachache acid regurgitation; Controlling bleeding due to trauma outward, eczema wets sore, ulcer being unable to heal.
Dried orange peel: be the dry mature skin of rutaceae orange CitrusreticulataBlanco and cultivated variety thereof. Pluck mature fruit, strip pericarp, dry or cryodrying. Regulate the flow of vital energy strong spleen, eliminating dampness and eliminating phlegm.
The banksia rose: be the dry root of the feverfew banksia rose. Autumn, season in winter two excavate, and remove silt and fibrous root, segment, and big vertical profile again becomes lobe, hit tertia after dry.
The bighead atractylodes rhizome: another name small wooden raft Ji, Yu Shu, the winter bighead atractylodes rhizome, wash rice art, poplar small wooden raft, Wu Shu, sheet art, rhizoma atractylodis etc., belong to composite family, Atractylodes per nnial herb. The nice and cool weather of happiness, is used as medicine with rhizome, has multinomial medicinal function. Mainly it is distributed in the mountain area wetlands such as Sichuan, Yunnan, Guizhou. The bighead atractylodes rhizome has invigorating the spleen and benefiting QI, eliminating dampness Li Shui, only sweat, and antiabortive effect, few for insufficiency of the spleen food, abdominal distension is had loose bowels, and phlegm and retained fluid is dizzy throbs with fear, oedema, spontaneous perspiration, threatened abortion.
Radix Glycyrrhizae: " Chinese medicine voluminous dictionary " is recorded: Radix Glycyrrhizae, [different name] lantern, honey sweet (" herbal classic "), honeywort, black grass (" not Lu "), state's old (" Collective Notes to the Canon of Materia medica "), well-informed (" account pearl "), powder grass (" beautiful and fragrant flowers spectrum "), sweet grass (" China's medicinal plant will "), sweet root (" Chinese medicine will "), rod grass (" Heilungkiang Chinese medicine "); [base is former] is the root and rhizome of pulse family glycyrrhiza genus Radix Glycyrrhizae, glycyrrhiza glabra, glycyrrhiza inflate bat; [function cures mainly] and middle emergency, moistening lung, removing toxic substances, coordinating the actions of various ingredients in a prescription; Processing with controlling weakness of the spleen and the stomach, burnout food is few, stomachache loose stool, the anxious pain of four limbs contraction, palpitaition, hysteria, and lung productive cough is coughed; Raw with controlling swelling and pain in the throat, carbuncle pyogenic infections from tumour or sore, infantile carbuncle, and medicine, food poisoning. Record according to Compendium of Material Medica: Radix Glycyrrhizae, also name honey is sweet, honeywort, lantern, grass, well-informed, state is old; Smell (root) is sweet, flat, nontoxic.
Bererini Hydrochclorium: a kind of morphinane alkaloid.
Semen daturae extractum: be the medicinal extract of Herba Belladonnae through being processed into.
The medicine of the present invention can astringing to arrest bleeding, relieving spasm to stop pain, can treat acute or chronic gastritis, the various stomach such as stomach ulcer and duodenal ulcer, in medicine there is not incompatibility in each raw material, sample treats, and healthy tendency of not speaking sarcastically, has no side effect, patient suffering can be solved rapidly, the lighter eats once namely effectively, and the effect that namely severe one has had for three to five times, can cure in seven to ten days.
The using method of the medicine of the present invention is: oral, a 5-6 sheet, and 3 times on the one, sheet weighs 0.4 gram, within 7 days, is 1 course for the treatment of.
In order to be illustrated more clearly in the present invention, enumerate following examples, but it is without any restrictions to the scope of invention.
Embodiment
Embodiment of the present invention being described in detail below in conjunction with embodiment, but it will be understood to those of skill in the art that, the following example is only for illustration of the present invention, and should not be considered as limiting the scope of the present invention.
Embodiment 1-14
Table 1 is embodiment 1-12, comparative example 1-5 uses raw material and quality.
Comparative example 1 eliminates Endoconcha Sepiae on the basis of embodiment 1, and comparative example 2 eliminates Semen daturae extractum on the basis of embodiment 1, and in comparative example 3-5, the weight proportion of Endoconcha Sepiae used and Semen daturae extractum is outside 80-95:1.
Table 1
The preparation method of above embodiment, comparative example medicine is as follows:
(1) getting the bighead atractylodes rhizome, Radix Glycyrrhizae boiling, boiling 3 times, each 1 hour, merge decocting liquid, filter, leave standstill 24 hours, get supernatant liquor, be condensed into cream clearly, water content is 15%-20%;
(2) Endoconcha Sepiae, dried orange peel, the banksia rose and Bererini Hydrochclorium are shattered into fine powder respectively, mix, obtained powder mix.
(3) clear cream step (1) produced, adds Semen daturae extractum and powder mix makes softwood, then crosses 20 order sieve granulations, dry granulating under 60 degree of conditions;
(4) 0.5% talcum powder is finally added and 0.5% Magnesium Stearate mixes even, tabletted.
Clinical trial one:
Choosing 240 example chronic gastritis patients, severity extent is close, the age between 40 years old-45 years old, through with western medicine, effect is not obvious.
Above 240 example patients being divided into 16 groups at random, often organizes 15 people, take the treatment stomach trouble medicine of embodiment 1-12 and comparative example 1-4 respectively, every day 3 times, each 6, every sheet weighs 0.4 gram, takes 2 courses for the treatment of, and concrete outcome is in table 2.
Table 2
| Recovery from illness | Take a turn for the better | Invalid | |
| Embodiment 1 | 15 examples | 0 example | 0 example |
| Embodiment 2 | 15 examples | 0 example | 0 example |
| Embodiment 3 | 15 examples | 0 example | 0 example |
| Embodiment 4 | 15 examples | 0 example | 0 example |
| Embodiment 5 | 15 examples | 0 example | 0 example |
| Embodiment 6 | 13 examples | 2 examples | 0 example |
| Embodiment 7 | 14 examples | 1 example | 0 example |
| Embodiment 8 | 15 examples | 0 example | 0 example |
| Embodiment 9 | 15 examples | 0 example | 0 example |
| Embodiment 10 | 15 examples | 0 example | 0 example |
| Embodiment 11 | 13 examples | 2 examples | 0 example |
| Embodiment 12 | 13 examples | 2 examples | 0 example |
| Comparative example 1 | 5 examples | 5 examples | 5 examples |
| Comparative example 2 | 6 examples | 5 examples | 4 examples |
| Comparative example 3 | 8 examples | 4 examples | 3 examples |
| Comparative example 4 | 9 examples | 4 examples | 2 examples |
| Comparative example 5 | 7 examples | 5 examples | 3 examples |
From the data of embodiment 1 and comparative example 1-5 it may be seen that have synergy based on the formula of medicine of the present invention, Endoconcha Sepiae and Semen daturae extractum for the treatment of stomach trouble, and their ratio better effects if within the specific limits.
Typical case:
(1) Wang, female, 45 years old, suffers from stomach ulcer 5 years, takes the embodiment of the present invention 1 medicine and cures 2 courses for the treatment of, not recurrence in 3 years so far.
(2) Lee, man, 30 years old, suffers from acute gastritis, and stomachache is more than, takes the embodiment of the present invention 2 medicine and namely takes effect for 1 time, takes recovery from illness in 3 days.
(3) Wang, man, 40 years old, Duodenal Ulcer Recurrence, took the embodiment of the present invention 2 medicine and takes effect for 1 time, takes recovery from illness in 7 days.
Claims (10)
1. treat the medicine of stomach trouble for one kind, it is characterized in that, comprise the bulk drug of following masses part proportioning: Endoconcha Sepiae 170-210 part, dried orange peel 40-70 part, banksia rose 80-110 part, bighead atractylodes rhizome 40-70 part, Radix Glycyrrhizae 170-200 part, Bererini Hydrochclorium 10-25 part, Semen daturae extractum 1.7-3 part.
2. the medicine for the treatment of stomach trouble according to claim 1, it is characterised in that described Endoconcha Sepiae is 180-195 part.
3. the medicine for the treatment of stomach trouble according to claim 1, it is characterised in that described dried orange peel is 50-60 part.
4. the medicine for the treatment of stomach trouble according to claim 1, it is characterised in that the described banksia rose is 90-105 part.
5. the medicine for the treatment of stomach trouble according to claim 1, it is characterised in that the described bighead atractylodes rhizome is 50-60 part.
6. the medicine for the treatment of stomach trouble according to claim 1, it is characterised in that described Radix Glycyrrhizae is 180-195 part.
7. the medicine for the treatment of stomach trouble according to claim 1, it is characterised in that described Bererini Hydrochclorium is 15-20 part.
8. the medicine for the treatment of stomach trouble according to claim 7, it is characterised in that described Semen daturae extractum is 1.7-2.5 part.
9. the medicine for the treatment of stomach trouble according to claim 7, it is characterised in that the ratio of described Endoconcha Sepiae and Semen daturae extractum is 80-95:1.
10. the preparation method of described treatment stomach trouble medicine according to claim 7, it is characterised in that comprise the steps:
(1) getting the bighead atractylodes rhizome, Radix Glycyrrhizae boiling, boiling 3 times, each 1-2 hour, merge decocting liquid, filter, leave standstill 24 hours, get supernatant liquor, be condensed into cream clearly, water content is 15%-20%;
(2) Endoconcha Sepiae, dried orange peel, the banksia rose and Bererini Hydrochclorium are shattered into fine powder respectively, mix, obtained powder mix;
(3) clear cream step (1) produced, adds Semen daturae extractum and powder mix makes softwood, then crosses the sieve granulation of 20-30 order, dry granulating when 60-70 degree;
(4) 0.5% talcum powder is finally added and 0.5% Magnesium Stearate mixes even, tabletted.
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| CN201610151626.1A CN105616690A (en) | 2016-03-17 | 2016-03-17 | Drug for treating stomach diseases and preparation method thereof |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1178111A (en) * | 1997-10-21 | 1998-04-08 | 肖启美 | Weijisan for gastropathy |
| CN101152449A (en) * | 2007-09-28 | 2008-04-02 | 修正药业集团股份有限公司 | Method of preparing traditional Chinese medicine preparation for treating tummy bug |
| CN103751688A (en) * | 2013-12-30 | 2014-04-30 | 臧萍 | Chinese herbal medicine for treating stomach diseases and preparation method of Chinese herbal medicine |
| CN104274812A (en) * | 2014-10-09 | 2015-01-14 | 于维嘉 | Traditional Chinese medicine for treatment of gastropathy |
| JP2015214530A (en) * | 2013-07-31 | 2015-12-03 | 興和株式会社 | Gastrointestinal agent composition |
-
2016
- 2016-03-17 CN CN201610151626.1A patent/CN105616690A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1178111A (en) * | 1997-10-21 | 1998-04-08 | 肖启美 | Weijisan for gastropathy |
| CN101152449A (en) * | 2007-09-28 | 2008-04-02 | 修正药业集团股份有限公司 | Method of preparing traditional Chinese medicine preparation for treating tummy bug |
| JP2015214530A (en) * | 2013-07-31 | 2015-12-03 | 興和株式会社 | Gastrointestinal agent composition |
| CN103751688A (en) * | 2013-12-30 | 2014-04-30 | 臧萍 | Chinese herbal medicine for treating stomach diseases and preparation method of Chinese herbal medicine |
| CN104274812A (en) * | 2014-10-09 | 2015-01-14 | 于维嘉 | Traditional Chinese medicine for treatment of gastropathy |
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Application publication date: 20160601 |