CN105616486A - Traditional Chinese medicine microbial fermentation preparation for improving milk performance of sows and preparing method of traditional Chinese medicine microbial fermentation preparation - Google Patents

Traditional Chinese medicine microbial fermentation preparation for improving milk performance of sows and preparing method of traditional Chinese medicine microbial fermentation preparation Download PDF

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CN105616486A
CN105616486A CN201510994633.3A CN201510994633A CN105616486A CN 105616486 A CN105616486 A CN 105616486A CN 201510994633 A CN201510994633 A CN 201510994633A CN 105616486 A CN105616486 A CN 105616486A
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chinese medicine
traditional chinese
microbial fermentation
preparation
fermentation
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张浩超
邹柳
连强
郭金权
曾战荣
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Fujian Ao Mulong Biological Engineering Co Ltd
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Fujian Ao Mulong Biological Engineering Co Ltd
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Abstract

The invention discloses a traditional Chinese medicine microbial fermentation preparation for improving the milk performance of sows and a preparing method of the traditional Chinese medicine microbial fermentation preparation. The preparing method comprises the steps that firstly, 3-15% of herba leonuri, 2-12% of cowherb seeds, 5-20% of radix astragali, 3-15% of radix angelica sinensis, 3-12% of ricepaperplant pith and 20-60% of senna are ground into 40-mesh powder; secondly, 0.4-2.4% of bacillus subtilis is inoculated into a culture medium, and the bacillus subtilis is inoculated into a fermentation tank for expanded culture when growing for 20-24 h, and culture is stopped when the culture time reaches 24-36 h; thirdly, the ground component materials are mixed evenly and added into water accounting for 1-1.2 fold of the total weight of the traditional Chinese medicine materials, the mixture is evenly stirred and sterilized with steam for 20-30 min under 100 DEG C, bacillus subtilis liquid accounting for 10% of the total weight of the traditional Chinese medicine materials and brown granulated sugar accounting for 0.5-5% of the total weight of the traditional Chinese medicine materials are added after cooling, the mixture is fermented for 7-10 days in the fermentation tank, and the mixture is dried at 35-50 DEG C after fermentation; fourthly, the fermented traditional Chinese medicine is evenly mixed with 0.2-1.6% of lactic acid enterococcus faecium, 0.05-2% of methionine, 0.2% of arginine, 0.2-4% of histidine, 0.1-3.5% of lysine, 0.1-4% of threonine and 2-40% of a yellow water-soluble carrier according to the formula proportion, and the mixture is then subjected to component packaging according to the packaging specification.

Description

Improve Chinese medicine microbial fermentation preparation and its preparation method of sow lactation performance
Technical field
The present invention relates to a kind of preparation, particularly relate to a kind of Chinese medicine microbial fermentation preparation improving sow lactation performance. The present invention also relates to the preparation method of the Chinese medicine microbial fermentation preparation of this improvement sow lactation performance.
Background technology
Lactation sow is in a very important status in whole sow production process, the quality of its lactation amount and milk directly affects weaned piglet body weight and survival rate, raise pigs and proverb was once mentioned: the many weightening finishes one jin of wean, delivering for sale under identical feeding and management condition and will increase weight ten jin more, these prove that lactation performance of lactating sows height directly affects the height of whole pig farm production benefit further.
And the number of milk yield of sow, the quality of milk quality is subject to the multifactor impacts such as sow food consumption, breast development situation and hormonal readiness. The sow gestation later stage due to fetus oppress that enteron aisle, hypokinesis, metabolism are vigorous, electrolyte disturbance etc., it is easy to produce the phenomenons such as constipation, apocleisis, hormone secretion be uneven; Sow postpartum, using of a large amount of anti-inflammatory drug for postpartum makes the matter worse to originally fragile gastro-intestinal system beyond doubt, namely while killing pathogenic bacterium also by probiotics in enteron aisle to killing, cause intestinal microflora unbalance, gastrointestinal dysfunction, greatly reduce sow digestion, assimilated efficiency, seriously affect sow lactation performance. Therefore, how effectively to improve milk yield of sow, milk quality is the problem received much concern in breeding production.
At present, it is to increase milk yield of sow, milk quality common method have: one, improve sow diet nutrient formula, it is to increase daily ration Middle nutrition concentration, meet body daily nutrition demand; Two, add the healthcare products such as herbal medicine, regulate body endocrine system; Three, add probiotic bacterium, improve animal body intestinal environment. Owing to sow lactation degraded performance is caused by multifactor, want from one of them factor or two factors, consider to improve sow lactation performance inadequate often, need factor from many aspects to consider.
Summary of the invention
It is an object of the invention to provide a kind of improve intestinal environment containing multiple traditional Chinese medicine ingredients and multiple probiotic bacterium and meta-bolites thereof, milk yield of sow can be significantly improved, promote milk quality, improve that piglet birth weight, wean be heavy and sucking piglets health degree comprehensively, and have no side effect, pollution-free, noresidue, the Chinese medicine microbial fermentation preparation of improvement sow lactation performance not producing resistance and its preparation method.
For achieving the above object, the present invention improves the Chinese medicine microbial fermentation preparation of sow lactation performance, it is characterised in that it is made up of following portions by weight:
Motherwort Herb 3 ~ 15% subtilis (20,000,000,000/gram) 0.4 ~ 2.4%
Semen Vaccariae 2 ~ 12% lactic acid faecium (30,000,000,000/gram) 0.2 ~ 1.6%
The Radix Astragali 5 ~ 20% methionine(Met) 0.05 ~ 2%
Radix Angelicae Sinensis 3 ~ 15% arginine 0.05 ~ 3%
The stem pith of the rice-paper plant 3 ~ 12% Histidine 0.2 ~ 4%
Pan rushes down leaf 20 ~ 60% Methionin 0.1 ~ 3.5%
Auxiliary U.S. yellow powder 2 ~ 40% Threonine 0.1 ~ 4%
Brown sugar (Saccharum Sinensis Roxb.) 0.5 ~ 5%, above each component sum is 100%.
Wherein the proportioning of each raw material weight is
Motherwort Herb 6% subtilis (20,000,000,000/gram) 1.2%
Semen Vaccariae 6% lactic acid faecium (30,000,000,000/gram) 0.8%
The Radix Astragali 12% methionine(Met) 0.2%
Radix Angelicae Sinensis 8% arginine 0.2%
The stem pith of the rice-paper plant 8% Histidine 0.4%
Pan rushes down leaf 40% Methionin 0.4%
Auxiliary U.S. yellow powder 15.4% Threonine 0.4%
Brown sugar (Saccharum Sinensis Roxb.) 1%.
Improving a preparation method for the Chinese medicine microbial fermentation preparation of sow lactation performance, the method comprises the step of following order:
(1) pre-treatment: Motherwort Herb 3 ~ 15%, Semen Vaccariae 2 ~ 12%, the Radix Astragali 5 ~ 20%, Radix Angelicae Sinensis 3 ~ 15%, the stem pith of the rice-paper plant 3 ~ 12%, Pan are rushed down each constituent materials of leaf 20 ~ 60% respectively grinding and processing become 40 object powder;
(2) prepare strain fermentating liquid: be inoculated in substratum by subtilis 0.4 ~ 2.4%, cultivate primary seed solution, when bacillus subtilis bacteria growing 20 ~ 24 is constantly little, it is inoculated in secondary seed fermentor tank respectively and carries out enlarged culturing, reach 24 ~ 36 little constantly stop cultivate, for subsequent use
(3) herb fermenting: each constituent materials good for pre-treatment is mixed, add the water of 1 ~ 1.2 times that accounts for Chinese medicine material gross weight, stir evenly, steam sterilizing 20 ~ 30 minutes at 100 DEG C, after cooling, add the subtilis liquid measure of 10% and the brown sugar (Saccharum Sinensis Roxb.) of 0.5 ~ 5% of Chinese medicine material gross weight, at fermentation cylinder for fermentation 7-10 days, after fermentation ends, dry under 35 ~ 50 DEG C of conditions, for subsequent use after being up to the standards;
(4) after after fermenting, Chinese medicine mixes by formula rate is composite with lactic acid faecium 0.2 ~ 1.6%, methionine(Met) 0.05 ~ 2%, arginine 0.2%, Histidine 0.2 ~ 4%, Methionin 0.1 ~ 3.5%, Threonine 0.1 ~ 4%, auxiliary U.S. yellow powder 2 ~ 40%, by packing specifications weight packaging.
During fermentation cylinder for fermentation, within first 2 days, stirring once every 24 hours, following every day stirred once every about 5 hours, within last 2 days, stirred once every 1 hour.
In described fermentor tank, temperature is 35 ~ 37 DEG C.
Dry to water content 15% under 35 ~ 50 DEG C of conditions.
Tool of the present invention has the following advantages:
Raise a mouthful property difference owing to common herbal product exists, active drug component content is low, molecular weight greatly, the not easily problem such as absorption. Chinese medicine is fermented by the present invention, then the method for microecology, bionics is utilized, by the mode of biological grafting, simulate the intestinal environment of livestock and poultry and the traditional Chinese medicine ingredients digest and decompose process in livestock and poultry in vitro, the middle pharmaceutically active ingredient extracted is carried out biological conversion, by the macromolecular substance of Chinese medicine, become the small molecules composition that directly can be absorbed by enteron aisle through microbial transformation, make Chinese medicine become the newtype drug of fast absorption, quantitatively curative effect. Motherwort Herb in the present invention has invigorates blood circulation, the stasis of blood of dispelling, menstruation regulating, and disappear water. Control prolonged lochia, hemostasis stomachache, retention of placenta, treatment oedema, dysuria. Semen Vaccariae has logical breast of invigorating blood circulation, expedites the emergence of lactogenesis, thymus gland dredging in postpartum. Cure mainly the blood stasis of blood through closing, dysmenorrhoea, difficult labour; Lack of lactation after delivery, acute mastitis swells and ache; Heat is drenched, and blood drenches, urolithiasis. The Radix Astragali has that to cure mainly the deficiency of vital energy weak, for fatigue and weakness, or sinking of QI of middle-JIAO, prolapse of the anus, uterine prolapse, there is the effects such as air making-up and spleen enlivening. Radix Angelicae Sinensis has enriches blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation. The all cards of the main deficiency of blood; Uterine bleeding; The cold of insufficiency type is suffered from abdominal pain; Impotence numbness; Numbness of the skin; Intestines are dry just difficult; Effect such as heavily after dysentery characterized by blood in the stool. The stem pith of the rice-paper plant has snobbish clearly water; Logical breast. The puckery pain of main stranguria; Dysuria; Oedema; Jaundice; Damp-warm diseases; Oliguria with reddish urine; Postpartum, breast was few; Through closing; Under band. Red for damp-warm syndrome urine, the puckery pain of gonorrhoea, oedema urine is few, agalactia. Pan is rushed down leaf and is had and cure mainly: the row that purges heat is stagnant, defaecation, Li Shui. Stagnating for thermojunction, constipation is suffered from abdominal pain, and it is full that oedema is swollen. Subtilis, lactic acid faecium have promotion growth of animal, regulate composition of gut flora, maintain microecological balance, thus improve gastrointestinal function; Improve feed digestibility and biological value; Suppress spoilage organism in enteron aisle, pathogenic bacterium growth: improve immunity of organisms etc. Methionine(Met), arginine, Histidine, Methionin and Threonine have (one) and meet animal needs promotion growth of animal, improve amino acid balance and improve efficiency of feed utilization, save protein resource; (2) nutritive value of plant protein and feed thereof is improved; (3) promoting the absorption of calcium, Methionin can promote that small intestine is to the absorption of calcium; (4) can resist stress disease; (5) resistance against diseases is improved; (6) animal diarrhea is prevented. By above-mentioned 6 taste Chinese medicine conditioning sow endocrine systems, then being aided with the probiotic bacterium regulating intestinal canal colony balances such as milk-acid bacteria, amino acid improves feed nutritive value, finally reaches, under three pipes are neat, the effect comprehensively promoting sow lactation performance.
The present invention, below in conjunction with embodiment, is further described by embodiment.
Embodiment one:
First Motherwort Herb 6%, Semen Vaccariae 6%, the Radix Astragali 12%, Radix Angelicae Sinensis 8%, the stem pith of the rice-paper plant 8%, Pan are rushed down each constituent materials of leaf 40% respectively grinding and processing become 40 object powder; Then subtilis 1.2% is inoculated in substratum, cultivate primary seed solution, when bacillus subtilis bacteria growing 20 ~ 24 is constantly little, be inoculated in secondary seed fermentor tank respectively and carry out enlarged culturing, reach 24 ~ 36 little constantly stop cultivate, for subsequent use; The each constituent materials crushed is mixed, add the water of 1 ~ 1.2 times that accounts for Chinese medicine material gross weight, stir evenly, steam sterilizing 20 ~ 30 minutes at 100 DEG C, after cooling, add the subtilis liquid measure of 10% and the brown sugar (Saccharum Sinensis Roxb.) of 1% of Chinese medicine material gross weight, 35 ~ 37 DEG C fermentation cylinder for fermentation 7-10 days, within first 2 days, stirred once every 24 hours, following every day stirred once every about 5 hours, within last 2 days, stirred once every 1 hour, after fermentation ends, dry under 35 ~ 50 DEG C of conditions to water content 15%, for subsequent use after being up to the standards; After Chinese medicine after fermentation is mixed by formula rate is composite with lactic acid faecium 0.8%, methionine(Met) 0.2%, arginine 0.2%, Histidine 0.4%, Methionin 0.4%, Threonine 0.4%, auxiliary U.S. yellow powder 15.4%, by packing specifications weight packaging.
Embodiment two
Motherwort Herb 3%, Semen Vaccariae 2%, the Radix Astragali 5%, Radix Angelicae Sinensis 15%, the stem pith of the rice-paper plant 12%, Pan are rushed down each constituent materials of leaf 20% respectively grinding and processing become 40 object powder; Then subtilis 0.4% is inoculated in substratum, cultivate primary seed solution, when bacillus subtilis bacteria growing 20 ~ 24 is constantly little, be inoculated in secondary seed fermentor tank respectively and carry out enlarged culturing, reach 24 ~ 36 little constantly stop cultivate, for subsequent use; The each constituent materials crushed is mixed, add the water of 1 ~ 1.2 times that accounts for Chinese medicine material gross weight, stir evenly, steam sterilizing 20 ~ 30 minutes at 100 DEG C, after cooling, add the subtilis liquid measure of 10% and the brown sugar (Saccharum Sinensis Roxb.) of 0.5% of Chinese medicine material gross weight, 35 ~ 37 DEG C fermentation cylinder for fermentation 7-10 days, within first 2 days, stirred once every 24 hours, following every day stirred once every about 5 hours, within last 2 days, stirred once every 1 hour, after fermentation ends, dry under 35 ~ 50 DEG C of conditions to water content 15%, for subsequent use after being up to the standards; After Chinese medicine after fermentation is mixed by formula rate is composite with lactic acid faecium 0.2%, methionine(Met) 0.05%, arginine 0.05%, Histidine 4%, Methionin 3.5%, Threonine 4%, auxiliary U.S. yellow powder 30.3%, by packing specifications weight packaging.
Embodiment three
Motherwort Herb 15%, Semen Vaccariae 12%, the Radix Astragali 20%, Radix Angelicae Sinensis 3%, the stem pith of the rice-paper plant 3%, Pan are rushed down each constituent materials of leaf 30.6% respectively grinding and processing become 40 object powder; Then subtilis 2.4% is inoculated in substratum, cultivate primary seed solution, when bacillus subtilis bacteria growing 20 ~ 24 is constantly little, be inoculated in secondary seed fermentor tank respectively and carry out enlarged culturing, reach 24 ~ 36 little constantly stop cultivate, for subsequent use; The each constituent materials crushed is mixed, add the water of 1 ~ 1.2 times that accounts for Chinese medicine material gross weight, stir evenly, steam sterilizing 20 ~ 30 minutes at 100 DEG C, after cooling, add the subtilis liquid measure of 10% and the brown sugar (Saccharum Sinensis Roxb.) of 5% of Chinese medicine material gross weight, 35 ~ 37 DEG C fermentation cylinder for fermentation 7-10 days, within first 2 days, stirred once every 24 hours, following every day stirred once every about 5 hours, within last 2 days, stirred once every 1 hour, after fermentation ends, dry under 35 ~ 50 DEG C of conditions to water content 15%, for subsequent use after being up to the standards; After Chinese medicine after fermentation is mixed by formula rate is composite with lactic acid faecium 1.6%, methionine(Met) 2%, arginine 3%, Histidine 0.2%, Methionin 0.1%, Threonine 0.1%, auxiliary U.S. yellow powder 2%, by packing specifications weight packaging.
Embodiment four
Motherwort Herb 4%, Semen Vaccariae 3%, the Radix Astragali 6%, Radix Angelicae Sinensis 4%, the stem pith of the rice-paper plant 4%, Pan are rushed down each constituent materials of leaf 60% respectively grinding and processing become 40 object powder; Then subtilis 1% is inoculated in substratum, cultivate primary seed solution, when bacillus subtilis bacteria growing 20 ~ 24 is constantly little, be inoculated in secondary seed fermentor tank respectively and carry out enlarged culturing, reach 24 ~ 36 little constantly stop cultivate, for subsequent use; The each constituent materials crushed is mixed, add the water of 1 ~ 1.2 times that accounts for Chinese medicine material gross weight, stir evenly, steam sterilizing 20 ~ 30 minutes at 100 DEG C, after cooling, add the subtilis liquid measure of 10% and the brown sugar (Saccharum Sinensis Roxb.) of 0.8% of Chinese medicine material gross weight, 35 ~ 37 DEG C fermentation cylinder for fermentation 7-10 days, within first 2 days, stirred once every 24 hours, following every day stirred once every about 5 hours, within last 2 days, stirred once every 1 hour, after fermentation ends, dry under 35 ~ 50 DEG C of conditions to water content 15%, for subsequent use after being up to the standards; After Chinese medicine after fermentation is mixed by formula rate is composite with lactic acid faecium 0.3%, methionine(Met) 0.1%, arginine 0.1%, Histidine 2%, Methionin 0.1%, Threonine 0.3%, auxiliary U.S. yellow powder 14.3%, by packing specifications weight packaging.
Embodiment five
Motherwort Herb 5%, Semen Vaccariae 5%, the Radix Astragali 5%, Radix Angelicae Sinensis 6%, the stem pith of the rice-paper plant 6%, Pan are rushed down each constituent materials of leaf 20% respectively grinding and processing become 40 object powder; Then subtilis 2% is inoculated in substratum, cultivate primary seed solution, when bacillus subtilis bacteria growing 20 ~ 24 is constantly little, be inoculated in secondary seed fermentor tank respectively and carry out enlarged culturing, reach 24 ~ 36 little constantly stop cultivate, for subsequent use; The each constituent materials crushed is mixed, add the water of 1 ~ 1.2 times that accounts for Chinese medicine material gross weight, stir evenly, steam sterilizing 20 ~ 30 minutes at 100 DEG C, after cooling, add the subtilis liquid measure of 10% and the brown sugar (Saccharum Sinensis Roxb.) of 1% of Chinese medicine material gross weight, 35 ~ 37 DEG C fermentation cylinder for fermentation 7-10 days, within first 2 days, stirred once every 24 hours, following every day stirred once every about 5 hours, within last 2 days, stirred once every 1 hour, after fermentation ends, dry under 35 ~ 50 DEG C of conditions to water content 15%, for subsequent use after being up to the standards; After Chinese medicine after fermentation is mixed by formula rate is composite with lactic acid faecium 1%, methionine(Met) 1%, arginase 12 %, Histidine 2%, Methionin 2%, Threonine 2%, auxiliary U.S. yellow powder 40%, by packing specifications weight packaging.
Above embodiment effect:
Test 1:
Experimental period and address: test and complete on Zhangping City Chen Yan pig farm on August 14,18 days to 2015 July in 2015.
Experiment purpose: verify this product clinical efficacy, observes product by data record and the growth of nascent piggy in lactation is increased weight, and weaning piglet, the aspects such as resistibility verify that product has the effect improving sow lactation performance.
Experimental technique:
Choose the basically identical delivery room of 2 conditions and A, B, more every is chosen at random for experimental group (12) the other side is blank group (11). Experimental group is added in delivery room sow feed product " nurse benefit is strong " 28g/ head/sky. Blank group is fed according to the original method of this factory.
Recording the gestational age of sow in experiment, litter size, piglet birth weight, weanling pig head number, the defective quantity of weanling pig, weanling pig weight etc., finally add up experimental result, compare two groups of experimental data results, analysed preparation curative effect.
Experimental result and analysis
Table 1, A experimental group and blank group result
Sow head number Birth piglet head number Birth all heavy (jin) Wean qualified head number Wean all heavy (jin) Wean does not conform to wresting number Dead head number
Experimental group 6 61 3.28 57 14.08 3 2
Control group 5 59 3.17 37 13.14 10 12
Differentiation 1 2 0.11 20 0.94 -7 -10
Table 2, B experimental group and blank group result
Sow head number Birth piglet head number Birth all heavy (jin) Wean qualified head number Wean all heavy (jin) Wean does not conform to wresting number Dead head number
Experimental group 6 69 3.11 38 14.42 4 6
Control group 6 73 3.66 35 13.14 16 10
Differentiation 0 -4 -0.55 3 1.28 -12 -4
A observation
Feed and do not find out two groups of gaps in first 5 days.
After feeding 10 days, two groups of piglets start change slowly occur, A middle control group piggy there are 3 hurdles to start phenomenon of having loose bowels occur, wherein it is numbered 86510 and 71022 sow institute band piggys phenomenon of having loose bowels serious, time length is long, all has no improvement after 7 days, and piggy is partially thin, piggy entirety can find out that difference in size is relatively big, and the indivedual head of the piggy in all the other hurdles is also less than normal; Being numbered 86227 and 81024 sow institute band piggys in A experimental group and occur phenomenon of having loose bowels equally, but the overall good evenness of piggy, phenomenon of having loose bowels maintains the time and short about substantially stops after 3-5 days, and sow milk bag fullness degree is good, and midway there is not wean to process yet.
After feeding 20 days, observing A two groups of sows and piggy situation, control group sow milk bag is substantial not, and the overall uniformity coefficient of piggy is poor, and size is uneven, and part piggy still has loose bowels. Experimental group sow milk bag is substantially full, and the overall uniformity coefficient of every hurdle piggy is basically identical, and indivedual head piggy has loose bowels. Contrasting two groups of piggys, obviously visible experimental group piggy is big compared with control group, and state of health is better.
After wean, control group weans defective piggy 6, substantially less than normal, minimum 5 jin, big 8 jin. Experimental group weans defective piggy 3, has substantially weighed 10 jin.
Feed and do not find out two groups of gaps in first 5 days.
July 31 (control group piglet birth 6-8 days, experimental group piglet birth 8-10 days), all there is phenomenon of having loose bowels in two groups of piglets. On August 5 to 8, two groups of two sows of respectively weaning in advance.
During whole process is fed, observing later experiments group sow and search for food more than control group, after wean, the sow milk of experimental group is sufficient, is rushed to other swinerys by poultry raiser and continues band piggy.
After wean, control group weans defective piggy 16, and experimental group weans defective piggy 4.
Can find out by table 1, table 2: the experimental group qualified piggy specific lobe control group that weans is many, and defective little pig's head number reduces greatly. In table 1, experimental group wean is all heavy: 14.08 jin. Control group: 13.14 jin, experimental group average weight gain 0.94 jin. In table 2, experimental group wean is all heavy: 14.42 jin, control group: 13.14 jin, experimental group average weight gain 1.28 jin.
Can find out that " nurse benefit is strong " is to sow milk bag fullness degree by two tables, it is to increase milk quality, has certain effect to improving in piglet resistibility.
Experiment 2
Experimental period and address: test and complete on pig farm, Longyan, Fujian on February 24,28 days to 2015 January in 2015.
Experiment purpose: verify this product clinical efficacy, observes product by data record and the growth of nascent piggy in lactation is increased weight, and weaning piglet, the aspects such as resistibility verify that product has the effect improving sow lactation performance.
Experimental technique:
Choose the basically identical delivery room of 2 conditions and A, B, it is divided into experimental group (20) and blank group (24) at random. Experimental group is added in delivery room sow feed this product 28g/ head/sky. Blank group is fed according to the original method of this factory.
Recording litter size in experiment, piglet birth weight, weanling pig head number, weanling pig weight, death toll etc., finally add up experimental result, compare two groups of experimental data results, analysed preparation curative effect.
Experimental result and analysis
Table 1, experimental group and blank group result
Birth all heavy (kg/ head) Wean all heavy (kg/ head) Have a net increase of heavily (kg/ head) Average daily gain (kg/ head) Mortality ratio (%)
Experimental group 1.76 8.20 6.44 234.21 4.8
Control group 1.72 7.52 5.80 210.91 9.4
Differentiation 0.04 0.68 0.64 23.30 -4.6
Note: piglet wean in 28 days
Experimental group is than the control group many weightening finish 0.68kg of wean, and the piglet birth weight of experimental group, average daily gain 0.04kg, 23.3g higher than control group respectively; Mortality ratio is lower than control group by 4.6%. Illustrate that this product weighs and reduces effect in piglet mortality ratio significantly, verify effect that this product is improved milk yield of sow in adjustment sow physiological function, promotes milk quality further from side in raising piglet birth weight, wean.
Experiment 3
Experimental period and address: test and complete on Shanghai-Hangzhou small stream mouth pig farm, Longyan, Fujian on November 10,8 days to 2014 October in 2014.
Experiment purpose: verify this product clinical efficacy, observes product by data record and the growth of nascent piggy in lactation is increased weight, and weaning piglet, the aspects such as resistibility verify that product has the effect improving sow lactation performance.
Experimental technique:
The delivery room choosing these 4 conditions basically identical is divided into 2 groups at random, i.e. experimental group (28) and blank group (26). Experimental group is added in delivery room sow feed product this product 500g/100kg. Blank group is fed according to the original method of this factory.
Recording litter size in experiment, piglet birth weight, weanling pig head number, weanling pig weight, death toll etc., finally add up experimental result, compare two groups of experimental data results, analysed preparation curative effect.
Experimental result and analysis
Table 1, experimental group and blank group result
Sow head number (head) Birth all heavy (kg/ head) Wean all heavy (kg/ head) Have a net increase of heavily (kg/ head) Mortality ratio (%)
Experimental group 28 1.44 6.55 5.110 4.76
Control group 26 1.45 6.10 4.653 9.88
Differentiation 2 -0.01 0.45 0.457 -5.12
Note: piglet wean in 21 days
Experimental group, than control group wean many weightening finish 0.45kg, many weightening finishes average every day 21g, reduces by 5.12% than the mortality ratio of control group, have dropped 51.8%. Experimental data shows that this product is to improve weaned piglet heavy and reduce effect in piglet mortality ratio two and give prominence to. Above data illustrate that this product is regulating the effect being improved milk yield of sow, lifting milk quality in sow physiological function further.

Claims (6)

1. one kind is improved the Chinese medicine microbial fermentation preparation of sow lactation performance, it is characterised in that it is made up of following portions by weight:
Motherwort Herb 3 ~ 15% subtilis (20,000,000,000/gram) 0.4 ~ 2.4%
Semen Vaccariae 2 ~ 12% lactic acid faecium (30,000,000,000/gram) 0.2 ~ 1.6%
The Radix Astragali 5 ~ 20% methionine(Met) 0.05 ~ 2%
Radix Angelicae Sinensis 3 ~ 15% arginine 0.05 ~ 3%
The stem pith of the rice-paper plant 3 ~ 12% Histidine 0.2 ~ 4%
Pan rushes down leaf 20 ~ 60% Methionin 0.1 ~ 3.5%
Auxiliary U.S. yellow powder 2 ~ 40% Threonine 0.1 ~ 4%
Brown sugar (Saccharum Sinensis Roxb.) 0.5 ~ 5%, above each component sum is 100%.
2. the Chinese medicine microbial fermentation preparation improving sow lactation performance according to claim 1, wherein the proportioning of each raw material weight is
Motherwort Herb 6% subtilis (20,000,000,000/gram) 1.2%
Semen Vaccariae 6% lactic acid faecium (30,000,000,000/gram) 0.8%
The Radix Astragali 12% methionine(Met) 0.2%
Radix Angelicae Sinensis 8% arginine 0.2%
The stem pith of the rice-paper plant 8% Histidine 0.4%
Pan rushes down leaf 40% Methionin 0.4%
Auxiliary U.S. yellow powder 15.4% Threonine 0.4%
Brown sugar (Saccharum Sinensis Roxb.) 1%.
3. improving a preparation method for the Chinese medicine microbial fermentation preparation of sow lactation performance, the method comprises the step of following order:
(1) pre-treatment: Motherwort Herb 3 ~ 15%, Semen Vaccariae 2 ~ 12%, the Radix Astragali 5 ~ 20%, Radix Angelicae Sinensis 3 ~ 15%, the stem pith of the rice-paper plant 3 ~ 12%, Pan are rushed down each constituent materials of leaf 20 ~ 60% respectively grinding and processing become 40 object powder;
(2) prepare strain fermentating liquid: be inoculated in substratum by subtilis 0.4 ~ 2.4%, cultivate primary seed solution, when bacillus subtilis bacteria growing 20 ~ 24 is constantly little, it is inoculated in secondary seed fermentor tank respectively and carries out enlarged culturing, reach 24 ~ 36 little constantly stop cultivate, for subsequent use
(3) herb fermenting: each constituent materials good for pre-treatment is mixed, add the water of 1 ~ 1.2 times that accounts for Chinese medicine material gross weight, stir evenly, steam sterilizing 20 ~ 30 minutes at 100 DEG C, after cooling, add the subtilis liquid measure of 10% and the brown sugar (Saccharum Sinensis Roxb.) of 0.5 ~ 5% of Chinese medicine material gross weight, at fermentation cylinder for fermentation 7-10 days, after fermentation ends, dry under 35 ~ 50 DEG C of conditions, for subsequent use after being up to the standards;
(4) after after fermenting, Chinese medicine mixes by formula rate is composite with lactic acid faecium 0.2 ~ 1.6%, methionine(Met) 0.05 ~ 2%, arginine 0.2%, Histidine 0.2 ~ 4%, Methionin 0.1 ~ 3.5%, Threonine 0.1 ~ 4%, auxiliary U.S. yellow powder 2 ~ 40%, by packing specifications weight packaging.
4. the preparation method of the Chinese medicine microbial fermentation preparation improving sow lactation performance according to claim 3, it is characterized in that: during fermentation cylinder for fermentation, within first 2 days, stirring once every 24 hours, following every day stirred once every about 5 hours, within last 2 days, stirred once every 1 hour.
5. the preparation method of the Chinese medicine microbial fermentation preparation improving sow lactation performance according to claim 3, it is characterised in that: in described fermentor tank, temperature is 35 ~ 37 DEG C.
6. the preparation method of the Chinese medicine microbial fermentation preparation improving sow lactation performance according to claim 3, it is characterised in that: dry to water content 15% under 35 ~ 50 DEG C of conditions.
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108244369A (en) * 2018-02-28 2018-07-06 山东和美华农牧科技股份有限公司 A kind of lactating sow special microelement fermented feed and preparation method thereof
CN108371252A (en) * 2018-03-16 2018-08-07 莱阳和美华饲料有限责任公司 A kind of herb fermenting feed addictive and its preparation method and application promoting the rehabilitation of sow postpartum inflammation and lactagogue
CN108653518A (en) * 2018-05-24 2018-10-16 湖北华大瑞尔科技有限公司 A kind of probiotics fermention Chinese medicine preparation and preparation method thereof
CN109589359A (en) * 2017-09-30 2019-04-09 河南牧动物药业有限公司 A kind of Chinese medicine composition for improving sow production performance, Chinese medicine microecological preparation and preparation method thereof
CN114869927A (en) * 2022-04-20 2022-08-09 徐丹 Medicated diet conditioner for improving health and strength of mother and baby in lactation period
CN116898896A (en) * 2023-08-30 2023-10-20 福建益昕葆生物制药有限公司 Traditional Chinese medicine composition for improving lactation yield of lactating sows and preparation and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102232487A (en) * 2011-04-15 2011-11-09 北京康华远景科技有限公司 Physiological regulator for maternal animals, and preparation method thereof
CN102232494A (en) * 2011-07-28 2011-11-09 郑州市大北农饲料科技有限公司 Chinese medicinal herb-containing lactating sow compound premix and compound feed prepared from same
CN104116010A (en) * 2014-05-30 2014-10-29 安徽省正大源饲料集团有限公司 Chinese medicine microecological preparation for lactating sows and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102232487A (en) * 2011-04-15 2011-11-09 北京康华远景科技有限公司 Physiological regulator for maternal animals, and preparation method thereof
CN102232494A (en) * 2011-07-28 2011-11-09 郑州市大北农饲料科技有限公司 Chinese medicinal herb-containing lactating sow compound premix and compound feed prepared from same
CN104116010A (en) * 2014-05-30 2014-10-29 安徽省正大源饲料集团有限公司 Chinese medicine microecological preparation for lactating sows and preparation method thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
吴周水等: "经产母猪缺乳症辩证施治", 《江西畜牧兽医杂志》 *
张文等: "芽孢杆菌发酵中药复方及抑菌活性的检测", 《广东饲料》 *
陈世泉等: "中西药结合防治母猪产后泌乳障碍综合征", 《广东畜牧兽医科技》 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109589359A (en) * 2017-09-30 2019-04-09 河南牧动物药业有限公司 A kind of Chinese medicine composition for improving sow production performance, Chinese medicine microecological preparation and preparation method thereof
CN108244369A (en) * 2018-02-28 2018-07-06 山东和美华农牧科技股份有限公司 A kind of lactating sow special microelement fermented feed and preparation method thereof
CN108371252A (en) * 2018-03-16 2018-08-07 莱阳和美华饲料有限责任公司 A kind of herb fermenting feed addictive and its preparation method and application promoting the rehabilitation of sow postpartum inflammation and lactagogue
CN108653518A (en) * 2018-05-24 2018-10-16 湖北华大瑞尔科技有限公司 A kind of probiotics fermention Chinese medicine preparation and preparation method thereof
CN108653518B (en) * 2018-05-24 2021-10-08 湖北华大瑞尔科技有限公司 Probiotic fermented traditional Chinese medicine preparation and preparation method thereof
CN114869927A (en) * 2022-04-20 2022-08-09 徐丹 Medicated diet conditioner for improving health and strength of mother and baby in lactation period
CN114869927B (en) * 2022-04-20 2024-04-16 徐丹 Medicated diet conditioner for improving health and strengthening of lactating female and male animals
CN116898896A (en) * 2023-08-30 2023-10-20 福建益昕葆生物制药有限公司 Traditional Chinese medicine composition for improving lactation yield of lactating sows and preparation and application thereof

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