CN105611930B - 作为非凋亡调控性细胞死亡抑制剂的螺环喹喔啉衍生物 - Google Patents

作为非凋亡调控性细胞死亡抑制剂的螺环喹喔啉衍生物 Download PDF

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CN105611930B
CN105611930B CN201480050767.3A CN201480050767A CN105611930B CN 105611930 B CN105611930 B CN 105611930B CN 201480050767 A CN201480050767 A CN 201480050767A CN 105611930 B CN105611930 B CN 105611930B
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CN105611930A (zh
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M·康拉德
J·希克
B·普罗内特
P·森亨
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Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt GmbH
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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CN201480050767.3A 2013-07-15 2014-07-15 作为非凋亡调控性细胞死亡抑制剂的螺环喹喔啉衍生物 Active CN105611930B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP13176581 2013-07-15
EP13176580.2 2013-07-15
EP13176582 2013-07-15
EP13176580 2013-07-15
EP13176581.0 2013-07-15
EP13176582.8 2013-07-15
PCT/EP2014/065145 WO2015007730A1 (en) 2013-07-15 2014-07-15 Spiroquinoxaline derivatives as inhibitors of non-apoptotic regulated cell-death

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CN105611930A CN105611930A (zh) 2016-05-25
CN105611930B true CN105611930B (zh) 2021-03-02

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US (3) USRE48992E1 (enExample)
EP (1) EP3021847B1 (enExample)
JP (3) JP6851825B2 (enExample)
CN (1) CN105611930B (enExample)
AU (1) AU2014292132B2 (enExample)
CA (1) CA2955059A1 (enExample)
ES (1) ES2955206T3 (enExample)
IL (1) IL243610B (enExample)
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JP6851825B2 (ja) 2013-07-15 2021-03-31 ヘルムホルツ ツェントゥルム ミュンヘン ドイチェス フォルシュングスツェントゥルム フューア ゲズントハイト ウント ウムヴェルト （ゲーエムベーハー） 非アポトーシス性の制御された細胞死の阻害剤としてのスピロキノキサリン誘導体
WO2016075137A1 (en) * 2014-11-10 2016-05-19 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Spiropyrazine derivatives as inhibitors of non-apoptotic regulated cell-death
US10858371B2 (en) 2016-09-23 2020-12-08 Purdue Research Foundation Anti-cancer agents and preparation thereof
GB201800994D0 (en) * 2018-01-22 2018-03-07 Ucl Business Plc Combination therapeutics
AU2019258078B2 (en) * 2018-04-27 2023-12-21 Chengdu Henghao Investment Co. Limited 10H-phenothiazine ferroptosis inhibitor and preparation method therefor and application thereof
CN111575362B (zh) * 2020-04-20 2021-10-29 中国医学科学院北京协和医院 一种预测系统性红斑狼疮疾病活动度的药物
JPWO2022075444A1 (enExample) 2020-10-09 2022-04-14
US11541116B1 (en) 2022-01-07 2023-01-03 Kojin Therapeutics, Inc. Methods and compositions for inducing ferroptosis in vivo
CN116589479B (zh) * 2023-04-24 2024-11-22 中国人民解放军海军军医大学 一种具有抗真菌活性的喹喔啉衍生物及其应用

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CA2955059A1 (en) 2015-01-22
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