CN105611925A - NSAID与σ受体配体的组合物 - Google Patents

NSAID与σ受体配体的组合物 Download PDF

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Publication number
CN105611925A
CN105611925A CN201480050356.4A CN201480050356A CN105611925A CN 105611925 A CN105611925 A CN 105611925A CN 201480050356 A CN201480050356 A CN 201480050356A CN 105611925 A CN105611925 A CN 105611925A
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CN
China
Prior art keywords
dichlorophenyl
pyrazole
oxygen base
ethyl
replacement
Prior art date
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Pending
Application number
CN201480050356.4A
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English (en)
Chinese (zh)
Inventor
丹尼尔·赞马尼罗·卡斯坦尼杜
恩里克·波蒂略·萨利多
恩里克·何塞·科沃斯·莫拉尔
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Esteve Pharmaceuticals SA
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Laboratorios del Dr Esteve SA
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Publication of CN105611925A publication Critical patent/CN105611925A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201480050356.4A 2013-09-12 2014-09-11 NSAID与σ受体配体的组合物 Pending CN105611925A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13382353.4 2013-09-12
EP13382353 2013-09-12
PCT/EP2014/069370 WO2015036470A1 (en) 2013-09-12 2014-09-11 Nsaid and sigma receptor ligand combinations

Publications (1)

Publication Number Publication Date
CN105611925A true CN105611925A (zh) 2016-05-25

Family

ID=49223707

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480050356.4A Pending CN105611925A (zh) 2013-09-12 2014-09-11 NSAID与σ受体配体的组合物

Country Status (17)

Country Link
US (1) US20160220574A1 (https=)
EP (1) EP3043795A1 (https=)
JP (1) JP2016530322A (https=)
KR (1) KR20160054547A (https=)
CN (1) CN105611925A (https=)
AR (1) AR100021A1 (https=)
AU (1) AU2014320399A1 (https=)
CA (1) CA2922330A1 (https=)
IL (1) IL244200A0 (https=)
MA (1) MA38957B1 (https=)
MX (1) MX2016002892A (https=)
PH (1) PH12016500356A1 (https=)
RU (1) RU2016113713A (https=)
SG (1) SG11201601304XA (https=)
TN (1) TN2016000084A1 (https=)
TW (1) TW201605433A (https=)
WO (1) WO2015036470A1 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107459510A (zh) * 2016-06-06 2017-12-12 华东师范大学 异恶唑类化合物及其应用
CN114040937A (zh) * 2019-07-03 2022-02-11 埃克森美孚研究工程公司 包含吡唑基苯甲酸根配体的金属-有机骨架材料及其制备方法
CN114728014A (zh) * 2019-11-01 2022-07-08 皮埃蒙特动物健康公司 治疗调配物及其用途
WO2025228442A1 (zh) * 2024-04-30 2025-11-06 厦门大学 氯苯唑酸在激活rxr活性中的用途

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2116539A1 (en) 2008-04-25 2009-11-11 Laboratorios Del. Dr. Esteve, S.A. 1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof
EP2353598A1 (en) 2010-02-04 2011-08-10 Laboratorios Del. Dr. Esteve, S.A. Sigma ligands for use in the prevention and/or treatment of postoperative pain
EP2353591A1 (en) 2010-02-04 2011-08-10 Laboratorios Del. Dr. Esteve, S.A. Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof
EP2388005A1 (en) 2010-05-21 2011-11-23 Laboratorios Del. Dr. Esteve, S.A. Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy
EP2415471A1 (en) 2010-08-03 2012-02-08 Laboratorios Del. Dr. Esteve, S.A. Use of sigma ligands in opioid-induced hyperalgesia
EP2524694A1 (en) 2011-05-19 2012-11-21 Laboratorios Del. Dr. Esteve, S.A. Use of sigma ligands in diabetes type-2 associated pain
TW201607538A (zh) 2013-12-17 2016-03-01 以斯提夫博士實驗室股份有限公司 血清素－去甲腎上腺素再攝取抑制劑（ＳＮＲＩＳ）和σ受體配體組合物
EP3415143A1 (en) 2017-06-16 2018-12-19 Kai-Uwe Kern Bromhexine for the treatment of pain
WO2020113094A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
WO2024105225A1 (en) * 2022-11-18 2024-05-23 Universitat De Barcelona Synergistic combinations of a sigma receptor 1 (s1r) antagonist and a soluble epoxide hydrolase inhibitor (sehi) and their use in the treatment of pain

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101010302A (zh) * 2004-08-27 2007-08-01 埃斯蒂维实验室股份有限公司 σ受体抑制剂
CN102066334A (zh) * 2008-04-25 2011-05-18 埃斯蒂维实验室股份有限公司 增强阿片样物质的镇痛作用和减弱其依赖性的作为σ配体的1-芳基-3-氨基烷氧基-吡唑
CN102497864A (zh) * 2009-08-14 2012-06-13 埃斯特韦实验室有限公司 用于预防或治疗由化疗诱发的疼痛的σ配体
CN102781445A (zh) * 2010-02-04 2012-11-14 埃斯特韦实验室有限公司 用于预防和/或治疗术后疼痛的σ配体
WO2012156497A1 (en) * 2011-05-19 2012-11-22 Laboratorios Del Dr. Esteve, S.A. Use of sigma ligands in diabetes type-2 associated pain

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3273329D1 (en) * 1981-06-26 1986-10-23 Upjohn Co Analgesic process and composition
AU2062892A (en) * 1991-08-16 1993-02-18 Mcneil-Ppc, Inc. Potentiation of antitussive effect of dextromethorphan
CA2576144C (en) * 2004-08-27 2012-12-11 Laboratorios Del Dr. Esteve, S.A. Sigma receptor inhibitors
EP2460519A1 (en) * 2010-12-03 2012-06-06 Laboratorios Del. Dr. Esteve, S.A. Use of sigma ligands in bone cancer pain
NZ707773A (en) * 2012-11-05 2019-05-31 Zafgen Inc Methods of treating liver diseases

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101010302A (zh) * 2004-08-27 2007-08-01 埃斯蒂维实验室股份有限公司 σ受体抑制剂
CN102066334A (zh) * 2008-04-25 2011-05-18 埃斯蒂维实验室股份有限公司 增强阿片样物质的镇痛作用和减弱其依赖性的作为σ配体的1-芳基-3-氨基烷氧基-吡唑
CN102497864A (zh) * 2009-08-14 2012-06-13 埃斯特韦实验室有限公司 用于预防或治疗由化疗诱发的疼痛的σ配体
CN102781445A (zh) * 2010-02-04 2012-11-14 埃斯特韦实验室有限公司 用于预防和/或治疗术后疼痛的σ配体
WO2012156497A1 (en) * 2011-05-19 2012-11-22 Laboratorios Del Dr. Esteve, S.A. Use of sigma ligands in diabetes type-2 associated pain

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107459510A (zh) * 2016-06-06 2017-12-12 华东师范大学 异恶唑类化合物及其应用
CN107459510B (zh) * 2016-06-06 2021-06-25 华东师范大学 异恶唑类化合物及其应用
CN114040937A (zh) * 2019-07-03 2022-02-11 埃克森美孚研究工程公司 包含吡唑基苯甲酸根配体的金属-有机骨架材料及其制备方法
CN114040937B (zh) * 2019-07-03 2023-11-10 埃克森美孚科技工程公司 包含吡唑基苯甲酸根配体的金属-有机骨架材料及其制备方法
CN114728014A (zh) * 2019-11-01 2022-07-08 皮埃蒙特动物健康公司 治疗调配物及其用途
WO2025228442A1 (zh) * 2024-04-30 2025-11-06 厦门大学 氯苯唑酸在激活rxr活性中的用途

Also Published As

Publication number Publication date
JP2016530322A (ja) 2016-09-29
US20160220574A1 (en) 2016-08-04
AR100021A1 (es) 2016-09-07
IL244200A0 (en) 2016-04-21
TW201605433A (zh) 2016-02-16
RU2016113713A3 (https=) 2018-06-29
TN2016000084A1 (en) 2017-07-05
SG11201601304XA (en) 2016-03-30
KR20160054547A (ko) 2016-05-16
MA38957B1 (fr) 2016-11-30
MA38957A1 (fr) 2016-04-29
EP3043795A1 (en) 2016-07-20
RU2016113713A (ru) 2017-10-17
CA2922330A1 (en) 2015-03-19
WO2015036470A1 (en) 2015-03-19
PH12016500356A1 (en) 2016-05-16
AU2014320399A1 (en) 2016-03-10
MX2016002892A (es) 2016-06-10

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