CN105597176B - A kind of discontinuous CRRT machine capability bascules - Google Patents
A kind of discontinuous CRRT machine capability bascules Download PDFInfo
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- CN105597176B CN105597176B CN201610059234.2A CN201610059234A CN105597176B CN 105597176 B CN105597176 B CN 105597176B CN 201610059234 A CN201610059234 A CN 201610059234A CN 105597176 B CN105597176 B CN 105597176B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
- A61M1/1623—Disposition or location of membranes relative to fluids
- A61M1/1627—Dialyser of the inside perfusion type, i.e. blood flow inside hollow membrane fibres or tubes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1694—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid
- A61M1/1696—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid with dialysate regeneration
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Abstract
A kind of discontinuous CRRT machine capability bascules, including blood circulation system, the first fluid circulation system being made up of hollow fiber dialyzer, drain pipe road, the first tripper, liquid pump, displacement liquid/dialysis fluid container, liquid back pipe road.Increase the second liquid circulatory system being made up of exogenous displacement liquid/dialysis fluid container, exogenous displacement liquid/dialysis fluid container drain pipe road, the second tripper, liquid pump, displacement liquid/dialysis fluid container, exogenous displacement liquid/dialysis fluid container liquid back pipe road.First fluid circulation system contacts with blood circulation system carries out mass exchange, because its volume is fixed, is not related to the change of capacity in exchange process.First fluid circulation system disconnects with hematological system, is connected to second liquid system and carries out fluid exchange, is allowed to refill clean fresh displacement liquid, then couple progress solute with hematological system and exchange.Above procedure constantly repeats, and reaches constant and removes solute purpose.
Description
Technical field
The present invention relates to a kind of continuous blood purification device, specifically a kind of discontinuous CRRT machine capabilities balance
Device.
Background technology
The English of CRRT (i.e. continuous renal replacement therapy) continuous renal replacement therapy
Abbreviation.Also known as CBP (continuous blood purification)；Bedside hemo-filtration.It is to use daily 24 hours or connect
A kind of long-time of nearly 24 hours, continuous extracorporeal blood purify therapy to substitute impaired renal function.
Nineteen ninety-five, in the international CRRT academic conferences of the first that San Diego, USA is held, CRRT is by formal definition：
It is all can continuity remove solute, and to organ function rise supporting function blood purification technology.The World War II phase
Between, Canadian Murray and Delmore succeed in developing First artificial kidney machine, and are used for clinical treatment renal failure in l946
Exhaust, later blood purification technology is rapidly developed.Blood purification is that blood samples of patients is led to external and filled by one kind purification
Put, remove the purpose that some of which morbid substance purification blood reaches treatment disease.It mainly includes haemodialysis, blood is filtered
Cross, hemodiafiltration, blood perfusion, plasma exchange, immuno absorbence etc..Blood purification therapy is not provided purely for treating at present
Acute and chronic patients with renal failure, also it has been widely applied in the rescue of Severe acute disease patient.
CRRT clinical practice targets are to remove internal excess moisture, remove internal metabolic waste, poisonous substance, correct Water-Electrolyte
It is disorderly, it is ensured that nutritional support, to promote graft function and remove various cell factors, inflammatory mediator.It can be used for：Various angiocarpy
Acute and chronic renal failure functional lability, Metabolism or with encephaledema, and Multiple Organ Dysfunction Syndrome, it is acute
Respiratory Distress Syndrome(RDS), crush syndrome, acute necrotic pancreatitis, chronic heart failure, hepatic encephalopathy, medicine and toxic poisoning etc.
Treatment.
At present, the CRRT machines clinically produced mostly using German Bei Lang companies, or the life of German Fresenius group
The CRRT machines of production, or the CRRT machines of some other brand carry out Continuous Renal Replace Threapy.
CRRT machines in the course of the work, it is necessary to accurately control disengaging cardiopulmonary bypass in patients liquid speed and amount, disengaging
The difference of amount of liquid is net ultrafiltration, i.e., from the moisture content removed in vivo.Usual CRRT machines are controlled by displacement liquid/dialysis liquid pump
Into the liquid velocity of extracorporal circulatory system, the speed of extracorporal circulatory system liquid is controlled out by waste drains pump, while also passes through CRRT machines
Scale inside device carrys out the amount of accurate dynamic measurement disengaging liquid, and feedback regulation displacement liquid/dialyzate, waste liquid pump speed reach
To the purpose of control disengaging extracorporal circulatory system amount of liquid.
It will be apparent that control disengaging fluid balance existing defects by way of scale dynamic measurement liquid weight：First, scale needs
Often calibration, precision can be also gradually reduced during use, second, scale measurement can only be carried out in inactive state, it is right in therapeutic process
The collision of machine can cause scale not work, therefore existing CRRT machines can not work in mobile environment.
Weighed to overcome using scale, the defects of CRRT machines can not be used in mobile environment, someone's research uses flow
The method of monitoring dynamically determines to realize the volume controlled of CRRT machines and flows into, flows out extracorporal circulatory system flow rate of liquid simultaneously basis
Sectional area calculates outflow.The method of dynamic measurement flow velocity includes magnetic current method and ultrasonic method.Although this method can avoid scale
The defects of can not being worked under mobile condition, but the defects of precision is inadequate, and error is big still be present.Instant flow measurement needs the several seconds
A flow is measured, need to be measured tens times in one minute, then each measurement result is added up and obtains the liquid in the unit interval
Amount.Even if therefore single measurement error very little, but the additive effect of measuring result error necessarily causes overall error very big many times.
It is that direct measurement obtains some period every time although also dynamic measures scale system for instant flow measurement
Interior total liquid output, rather than by the cumulative of multiple measurement results, therefore additive effect is not present.It is in addition, micro- in liquid
The change of minute bubbles and pipe section product in use can all influence flow measurement precision.
For CRRT treatments, daily fluid exchange amount reaches as high as more than 100L, such as error typically in more than 20L
Within 1%, the liquid margin of error is 200ml-1000ml, if the treatment absolute error amount of continuous a few days is bigger.And flowmeter
Control capability balance error is difficult to reach less than 1%.
Existing CRRT machines can not be useful in progress CRRT in the Moveable type vehicles such as aircraft, automobile, train, steamer and control
Treat, this is just to being badly in need of CRRT treatments, and due to the limitation in distance and the vehicles, can not carry out CRRT treatments and bring to choose
War, such as the injured soldier in battlefield can only transport medical base rescue and treatment back, and patient with severe symptoms can not rob ambulance is enterprising
Rescue and treat.
Therefore CRRT machines need more convenient use, more accurate capacity control device and system.
The content of the invention
In order to solve the above-mentioned technical problem, a kind of discontinuous CRRT machine capability bascules of present invention proposition, including by
Enter blood vessel road, blood pump, hollow fiber dialyzer, the blood circulation system of blood back pipeline composition, by hollow fiber dialyzer, go out liquid
Pipeline, the first tripper, liquid pump, displacement liquid/dialysis fluid container, the first fluid circulation system of liquid back pipe road composition, the
One fluid circulation system and blood circulation system use common hollow fiber dialyzer, the blood and first in blood circulation system
Displacement liquid/dialyzate in fluid circulation system carries out solute exchange by common hollow fiber dialyzer, and hollow fibre is saturating
Parser includes blood inlet, blood outlet, displacement liquid/dialyzate outlet, displacement liquid/dialyzate entrance.
It is described enter blood vessel road one end introduce patient vessel after, hollow fiber dialyzer is coupled through the other end by blood pump
Blood inlet, the blood outlet of one end connection hollow fiber dialyzer of the blood back pipeline, the other end is by blood recovery patient
In vivo.
Displacement liquid/dialyzate outlet of one end connection hollow fiber dialyzer on the drain pipe road is coupled through first and broken
After road device, liquid pump, couple the entrance of displacement liquid/dialysis fluid container, one end connection displacement liquid/dialysis on the liquid back pipe road
The outlet of liquid container, by directly coupling blood back pipeline after the first tripper or entering blood vessel road, or connection displacement liquid/dialyzate
Outlet or displacement liquid/dialyzate arrival end.
Under forward and backward dilution filtration pattern, displacement liquid/dialysis of one end connection hollow fiber dialyzer on the drain pipe road
The liquid port of export, the one end on the liquid back pipe road then couples blood back pipeline or enters blood vessel road, then hollow fiber dialyzer is corresponding
Displacement liquid/dialyzate inlet seal.Displacement liquid/dialyzate of one end connection hollow fiber dialyzer on the drain pipe road enters
Mouth end, then seal the corresponding displacement liquid of hollow fiber dialyzer/dialyzate port of export.
Under dialysis mode, displacement liquid/dialyzate port of export of the drain pipe road connection hollow fiber dialyzer, described time
Liquid pipeline couples displacement liquid/dialyzate arrival end of hollow fiber dialyzer.
Also include by exogenous displacement liquid/dialysis fluid container, exogenous displacement liquid/dialysis fluid container drain pipe road, second
Second liquid of tripper, liquid pump, displacement liquid/dialysis fluid container, exogenous displacement liquid/dialysis fluid container liquid back pipe road composition
Systemic circulatory system, the exogenous displacement liquid/dialysis fluid container drain pipe road are drawn from exogenous displacement liquid/dialysis fluid container,
By coupling after the second tripper on the drain pipe road occupy between the first tripper and liquid pump, the exogenous displacement
After the liquid back pipe pass under displacement liquid/dialysis fluid container goes out, the other end is disconnected through second for liquid/dialysis fluid container liquid back pipe road one end
Road device feeds back exogenous displacement liquid/dialysis fluid container.
When the closing of the second tripper, when the first tripper is opened, the displacement liquid/dialysis fluid container, hollow fibre
Dialyzer, drain pipe road, the first fluid circulation system of liquid back pipe road composition are fixed into closed fluid circulation system, volume.
When the first tripper close, when the second tripper is opened, it is described by exogenous displacement liquid/dialysis fluid container,
Exogenous displacement liquid/dialysis fluid container drain pipe road, displacement liquid/dialysis fluid container, exogenous displacement liquid/dialysis fluid container return liquid
The second liquid circulatory system of pipeline composition turns into open fluid circulation system, the exogenous displacement liquid/dialysis fluid container
It is replaceable.
The ultrafiltration system being made up of ultrafiltration pipeline, ultrafiltrate pump, ultrafiltration container is additionally provided with the front end on drain pipe road.
The ultrafiltration system also includes flow-monitoring device, and the flow-monitoring device is arranged on ultrafiltration pipeline, to super
Flow rate of liquid and flow in chimney filter road are monitored.
First tripper and the second tripper are tubing clamp.
First tripper and the second tripper linkage, is opened and is closed by CRRT machine coordinated signals, when
When CRRT machines open the first tripper, the linkage of the second tripper is closed, the first fluid circulation system and blood circulation system
System carries out mass exchange in hollow fiber dialyzer；When CRRT the first trippers of machine switched off, the second tripper connection
Dynamic open-minded, the second liquid circulatory system is operated, and is produced when the first fluid circulation system works in displacement liquid/dialysis fluid container
Waste liquid enter the second liquid circulatory system in circulation, dilution, feed back in exogenous displacement liquid/dialysis fluid container.
First tripper has 2, respectively on drain pipe road, liquid back pipe road, links to drain pipe road, returns liquid
Pipeline is closed, Open control；Second tripper has 2, respectively positioned at exogenous displacement liquid/dialysis fluid container drain pipe
It is linkage exogenous displacement liquid/dialysis fluid container drain pipe road, outer on road, exogenous displacement liquid/dialysis fluid container liquid back pipe road
Source property displacement liquid/dialysis fluid container liquid back pipe road is closed, Open control.
It is 100-500ml that first fluid circulation system, which exchanges volume,.
The tubing clamp presss from both sides to be unidirectional, or two-way grip, or multidirectional folder.
Discontinuous CRRT machine capability bascule mentalities of designing and principle of the present invention are as follows：
CRRT fluid balances are actual including two parts, and the equivalent that a part is into and out liquid is explained, and a part is internal water
The removing divided, that is, " dehydration " being commonly called as.Because Part I fluid exchange amount is big, required precision is high, realizes more difficult；And the
Two parts are general per daily amount<4L, total amount is small, and required precision is small, and realization is relatively easy to.Existing CRRT machines put this two parts
Realize together.And we design new capacity control system and two parts then are separated into consideration, i.e., first done with high accuracy disengaging
The equivalent of liquid exchanges, then realizes the dehydration of low precision.
Common CRRT systems can be divided into two parts, and one is blood circulation system, and two be fluid circulation system.The present invention's
Thinking is second fluid circulation system of increase, and first fluid circulation system is designed as closed, and volume is fixed.First
Individual fluid circulation system contacts with blood circulation system carries out mass exchange, because its volume is fixed, is not related in exchange process
And the change of capacity, but due to its limited volume, both rear balance that basically reaches just does not have to a certain extent with arterial-venous transit
Solute removal acts on, and now the liquid in the liquid system can be described as waste liquid.In this case, by first liquid circulation
System disconnects with hematological system, is connected to second liquid system and carries out fluid exchange, second liquid system is open system
System, couple fresh clean displacement liquid, the waste liquid in first systematic is swapped out by fluid exchange, be allowed to refill clean new
Fresh displacement liquid.As hereafter again disconnected first liquid system and second liquid system, and turn into the appearance system such as closed again,
Couple progress solute with hematological system again to exchange.Above procedure constantly repeats, and reaches constant and removes solute purpose.
The basic ideas of this design be using enclosed positive displacement fix liquid system carry out solute exchange, guaranteed capacity without
Change, then the liquid system to having reached saturation regenerate, to ensure to continue Solute removal ability.
Discontinuous CRRT machine capability bascule implementations：Two of hematological system are passed in and out in first liquid system
Side by side, second liquid system passes in and out exogenous two pipelines of displacement liquid side by side to pipeline, is realized by a two-way grip come management and control
Folder closes the pipeline of disengaging hematological system, the pipeline of open disengaging displacement liquid, or on the contrary, pipeline, the folder of open disengaging hematological system
Close the pipeline of disengaging displacement liquid.First liquid system exchanges volume and may be designed as 100-500ml, and first liquid system follows again
Ring pump rate and switching frequency are set according to clinical treatment dose requirements.Extra liquid is removed, can be super by increasing by one
Filter pump, going out progress ultrafiltration, dehydrating amount at filter in first systematic can be realized by traffic monitoring.
The advantages of this mode is succinct, and shortcoming is that have part-time to be used for the regeneration of first circulation and do not treated.
Beneficial effect：
Discontinuous CRRT machine capabilities bascule of the present invention fixes liquid system using enclosed positive displacement and carries out solute friendship
Change, guaranteed capacity is unchanged, reaches saturation or during close to saturation when exchanging liquid, is carried out again by exogenous displacement liquid/dialyzate
It is raw, to ensure to continue Solute removal ability, solve the problems, such as that existing CRRT machines can not use in mobile environment.Can
It is widely used in CAVH under mobile environment (CAVH), failure by CVVH (CVVH), continuous
It is slow ultrafiltration (SCUF), continuous arteriovenous haemodialysis (CAVHD), Continuous Veno-venous haemodialysis (CVVHD), continuous dynamic
Venous blood dialysis filtration (CAVHDF), Continuous Veno-venous hemodiafiltration (CVVHDF).
Brief description of the drawings
Dilution filtration mode configuration schematic diagram after Fig. 1 discontinuous CRRT machine capability bascules；
Filtration pattern dual circuit clamping structure schematic diagram is diluted after Fig. 2 discontinuous CRRT machine capability bascules；
Dilution filtration banding ultrafiltration structural representation after Fig. 3 discontinuous CRRT machine capability bascules；
Dilution filtration banding ultrafiltration dual circuit clamping structure schematic diagram after Fig. 4 discontinuous CRRT machine capability bascules；
Dilution filtration mode configuration schematic diagram before Fig. 5 discontinuous CRRT machine capability bascules；
Filtration pattern dual circuit clamping structure schematic diagram is diluted before Fig. 6 discontinuous CRRT machine capability bascules；
Dilution filtration banding ultrafiltration structural representation before Fig. 7 discontinuous CRRT machine capability bascules；
Dilution filtration banding ultrafiltration dual circuit clamping structure schematic diagram before Fig. 8 discontinuous CRRT machine capability bascules；
Fig. 9 discontinuous CRRT machine capability bascule dialysis mode structural representations；
Figure 10 discontinuous CRRT machine capability bascule dialysis mode dual circuit clamping structure schematic diagrames；
Figure 11 discontinuous CRRT machine capability bascules dialysis mode band ultrafiltration structural representation；
Figure 12 discontinuous CRRT machine capability bascules dialysis mode band ultrafiltration dual circuit clamping structure schematic diagram；
Wherein：
Enter blood vessel road 1, blood pump 2, hollow fiber dialyzer 3, blood back pipeline 4, drain pipe road 5, the first tripper 6, liquid
Body pump 7, displacement liquid/dialysis fluid container 8, liquid back pipe road 9, blood inlet 10, blood outlet 11, displacement liquid/dialyzate outlet 12,
Displacement liquid/dialyzate entrance 13, exogenous displacement liquid/dialysis fluid container 14, exogenous displacement liquid/dialysis fluid container drain pipe road
15th, the second tripper 16, exogenous displacement liquid/dialysis fluid container liquid back pipe road 19, ultrafiltration pipeline 20, ultrafiltrate pump 21, ultrafiltration
Container 22.
Embodiment
Embodiment 1：As shown in figs. 1-12, a kind of discontinuous CRRT machine capability bascules, including by enter blood vessel road 1,
The blood circulation system that blood pump 2, hollow fiber dialyzer 3, blood back pipeline 4 form, by hollow fiber dialyzer 3, drain pipe road
5th, the first fluid circulation system that the first tripper 6, liquid pump 7, displacement liquid/dialysis fluid container 8, liquid back pipe road 9 form, the
One fluid circulation system and blood circulation system use common hollow fiber dialyzer 3, blood in blood circulation system and
Displacement liquid/dialyzate in first fluid circulation system carries out solute exchange, hollow fibre by common hollow fiber dialyzer 3
Tieing up dialyzer 3 includes blood inlet 10, blood outlet 11, displacement liquid/dialyzate outlet 12, displacement liquid/dialyzate entrance 13.
It is described enter blood vessel road 1 one end introduce patient vessel after, by blood pump 2 through the other end couple hollow fiber dialyzer
3 blood inlet 10, the blood outlet 11 of one end connection hollow fiber dialyzer 3 of the blood back pipeline 4, the other end is by blood
Feed back patient's body.
Displacement liquid/dialyzate the outlet 12 of one end connection hollow fiber dialyzer 3 on the drain pipe road 5 or displacement liquid/
The end of dialyzate entrance 13, or couple into blood vessel road 1, after the first tripper 6, liquid pump 7, couple displacement liquid/dialyzate
The entrance of container 8, the outlet of one end connection displacement liquid/dialysis fluid container 8 on the liquid back pipe road 9, passes through the first tripper 6
Directly couple blood back pipeline 4, or connection displacement liquid/dialyzate outlet 13 or displacement liquid/end of dialyzate entrance 12 afterwards.
Afterwards under diluting type filtration pattern, the displacement liquid of the one end on the drain pipe road 5 connection hollow fiber dialyzer 3/thoroughly
Liquid outlet 12 or displacement liquid/end of dialyzate entrance 13 are analysed, then is entered the corresponding displacement liquid/dialyzate of hollow fiber dialyzer 3
Mouth 13, or displacement liquid/dialyzate port of export 12 seal；
Under preceding diluting type filtration pattern, if the displacement liquid of one end connection hollow fiber dialyzer 3 on the liquid back pipe road 9/
The end of dialyzate entrance 12 or displacement liquid/dialyzate export 13 ends, then by the corresponding displacement liquid/dialysis of hollow fiber dialyzer 3
Liquid outlet 13, or change the liquid/end of dialyzate entrance 12 sealing；
Under dialysis mode, the drain pipe road 5 couples displacement liquid/dialyzate outlet 12 of hollow fiber dialyzer 3, described
Liquid back pipe road 9 couples displacement liquid/dialyzate entrance 13 of hollow fiber dialyzer 3；
Also include by exogenous displacement liquid/dialysis fluid container 14, exogenous displacement liquid/dialysis fluid container drain pipe road 15,
Second tripper 16, liquid pump 7, displacement liquid/dialysis fluid container 8, exogenous displacement liquid/19 groups of dialysis fluid container liquid back pipe road
Into the second liquid circulatory system, the exogenous displacement liquid/dialysis fluid container drain pipe road 15 is from exogenous displacement liquid/dialysis
Liquid container 14 is drawn, by coupling the liquid back pipe road occupy between the first tripper 6 and liquid pump 7 after the second tripper 16
On 5, the exogenous displacement liquid/one end of dialysis fluid container liquid back pipe road 19 is from the liquid back pipe road under displacement liquid/dialysis fluid container 8
After 9 draw, the other end feeds back exogenous displacement liquid/dialysis fluid container 14 through the second tripper 16.
It is the displacement liquid/dialysis fluid container 8, hollow when the second tripper 16 is closed, and the first tripper 6 is opened
The first fluid circulation system that fiber dialysis device 3, drain pipe road 5, liquid back pipe road 9 form holds into closed fluid circulation system
Product is fixed.
It is described to be held by exogenous displacement liquid/dialyzate when the first tripper 6 is closed, and the second tripper 16 is opened
Device 14, exogenous displacement liquid/dialysis fluid container drain pipe road 15, displacement liquid/dialysis fluid container 8, exogenous displacement liquid/dialyzate
The second liquid circulatory system that container liquid back pipe road 19 forms turns into open fluid circulation system, and the exogenous displacement liquid/
Dialysis fluid container 14 is replaceable.
The ultrafiltration system being made up of ultrafiltration pipeline 20, ultrafiltrate pump 21, ultrafiltration container 22 is additionally provided with the front end on drain pipe road 5
System.
The ultrafiltration system also includes flow-monitoring device, and the flow-monitoring device is arranged on ultrafiltration pipeline 20, right
Flow rate of liquid and flow in ultrafiltration pipeline 20 are monitored.
The tripper 16 of first tripper 6 and second is tubing clamp.
The tripper 16 of first tripper 6 and second links, and is opened and is closed by CRRT machine coordinated signals, when
When CRRT machines open the first tripper 6, the linkage of the second tripper 16 is closed, the first fluid circulation system and blood circulation
System carries out mass exchange in hollow fiber dialyzer 3；When CRRT the first trippers 6 of machine switched off, the second open circuit dress
It is open-minded to put 16 linkages, the second liquid circulatory system is operated, the first fluid circulation system work in displacement liquid/dialysis fluid container 8
Waste liquid caused by work enters circulation in the second liquid circulatory system, dilution, feeds back to exogenous displacement liquid/dialysis fluid container 14
It is interior.
First tripper 6 has 2, respectively on drain pipe road 5, liquid back pipe road 9, link to drain pipe road 5,
Liquid back pipe road 9 is closed, Open control；Second tripper 16 has 2, holds respectively positioned at exogenous displacement liquid/dialyzate
On device drain pipe road 15, exogenous displacement liquid/dialysis fluid container liquid back pipe road 19, linkage exogenous displacement liquid/dialyzate holds
Device drain pipe road 15, exogenous displacement liquid/dialysis fluid container liquid back pipe road 19 are closed, Open control.
It is 100-500ml that first fluid circulation system, which exchanges volume,.
The tubing clamp presss from both sides to be unidirectional, or two-way grip, or multidirectional folder.
According to the difference of therapeutic modality, continuously treatment can generally speaking be divided into two kinds of filtration pattern and dialysis mode to CRRT,
Filtration pattern can be divided into rear diluting type filtration and preceding diluting type filtration pattern both of which again.
When to filter pattern, displacement liquid/dialysis fluid container commonly referred to as replaces liquid container；Exogenous displacement liquid/dialysis
Liquid container is commonly referred to as exogenous displacement liquid container, and displacement liquid and dialyzate are identical liquid, contain the container of the liquid also
For identical container.
When for dialysis mode when, displacement liquid/dialysis fluid container is commonly referred to as dialysis fluid container；Exogenous displacement liquid/dialysis
Liquid container is commonly referred to as exogenous dialysis fluid container, and displacement liquid and dialyzate are identical liquid, contain the container of the liquid also
For identical container.
Embodiment 2：As Figure 1-4, filtration pattern is diluted after being, when to filter pattern, displacement liquid/dialysis fluid container
Commonly referred to as replace liquid container；Exogenous displacement liquid/dialysis fluid container is commonly referred to as exogenous displacement liquid container, displacement liquid with thoroughly
Analysis liquid is identical liquid, and blood back pipeline inputs after simply liquid is by hollow fiber dialyzer in the first fluid circulation system
Into blood, and non-input is to hollow dialysis dialyzer displacement liquid/dialyzate arrival end.
A kind of discontinuous CRRT machine capability bascules, including by enter blood vessel road 1, blood pump 2, hollow fiber dialyzer 3,
The blood circulation system that blood back pipeline 4 forms, by hollow fiber dialyzer 3, drain pipe road 5, the first tripper 6, liquid pump
7th, liquid container 8 is replaced, the first fluid circulation system that liquid back pipe road 9 forms, the first fluid circulation system and blood circulation system
Using common hollow fiber dialyzer 3, the blood in blood circulation system leads to the displacement liquid in the first fluid circulation system
Cross common hollow fiber dialyzer 3 and carry out solute exchange, hollow fiber dialyzer 3 include blood inlet 10, blood outlet 11,
Displacement liquid outlet 12, displacement liquid entrance 13.
It is described enter blood vessel road 1 one end introduce patient vessel after, by blood pump 2 through the other end couple hollow fiber dialyzer
3 blood inlet 10, the blood outlet 11 of one end connection hollow fiber dialyzer 3 of the blood back pipeline 4, the other end is by blood
Feed back patient's body.
The displacement liquid outlet 12 of one end connection hollow fiber dialyzer 3 on the drain pipe road 5, can also couple displacement liquid
The end of entrance 13, if connection displacement liquid exports 12 ends, the end seal of displacement liquid entrance 13 is closed, if connection displacement liquid entrance 13
End, then displacement liquid is exported into 12 end seals and closed, after the drain pipe road 5 is by the first tripper 6, liquid pump 7, couple displacement liquid
The entrance of container 8, the outlet of one end connection displacement liquid container 8 on the liquid back pipe road 9, by direct after the first tripper 6
Couple blood back pipeline 4；
Also include by exogenous displacement liquid container 14, exogenous displacement liquid container drain pipe road 15, the second tripper 16,
Liquid pump 7, displacement liquid container 8, the second liquid circulatory system of the exogenous composition of displacement liquid container liquid back pipe road 19, the external source
Property displacement liquid container drain pipe road 15 drawn from exogenous displacement liquid container 14, occupy the by coupling after the second tripper 16
On drain pipe road 5 between one tripper 6 and liquid pump 7, described exogenous one end of displacement liquid container liquid back pipe road 19 is from putting
After changing the extraction of the liquid back pipe road 9 under liquid container 8, the other end feeds back exogenous displacement liquid container 14 through the second tripper 16；
When the second tripper 16 is closed, when the first tripper opens 6, the displacement liquid container 8, hollow fibre are dialysed
The first fluid circulation system that device 3, drain pipe road 5, liquid back pipe road 9 form is fixed into closed fluid circulation system, volume；
When the first tripper 6 is closed, and the second tripper 16 is opened, it is described by exogenous displacement liquid container 14, it is outer
Source property displacement liquid container drain pipe road 15, displacement liquid container 8, the second liquid of the exogenous composition of displacement liquid container liquid back pipe road 19
The circulatory system turns into open fluid circulation system, and the exogenous displacement liquid container 14 is replaceable.
As shown in Figure 3,4, it is additionally provided with the front end on drain pipe road 5 by ultrafiltration pipeline 20, ultrafiltrate pump 21,22 groups of ultrafiltration container
Into ultrafiltration system.
The ultrafiltration system also includes flow-monitoring device, and the flow-monitoring device is arranged on ultrafiltration pipeline 20, right
Flow rate of liquid and flow in ultrafiltration pipeline 20 are monitored.
The tripper 16 of first tripper 6 and second is tubing clamp.
The tripper 16 of first tripper 6 and second links, and is opened and is closed by CRRT machine coordinated signals, when
When CRRT machines open the first tripper 6, the linkage of the second tripper 16 is closed, the first fluid circulation system and blood circulation
System carries out mass exchange in hollow fiber dialyzer 3；When CRRT the first trippers 6 of machine switched off, the second open circuit dress
It is open-minded to put 16 linkages, the second liquid circulatory system is operated, the first fluid circulation system work in displacement liquid/dialysis fluid container 8
Waste liquid caused by work enters circulation in the second liquid circulatory system, dilution, feeds back to exogenous displacement liquid/dialysis fluid container 14
It is interior.
As shown in Figure 3,4, first tripper 6 has 2, respectively on drain pipe road 5, liquid back pipe road 9, linkage
To drain pipe road 5, liquid back pipe road 9 closed, Open control；Second tripper 16 has 2, respectively positioned at exogenous displacement
On liquid container drain pipe road 15, exogenous displacement liquid container liquid back pipe road 19, linkage exogenous displacement liquid/dialysis fluid container goes out
Liquid pipeline 15, exogenous displacement liquid container liquid back pipe road 19 are closed, Open control.
It is 100-500ml that first fluid circulation system, which exchanges volume,.
The tubing clamp presss from both sides to be unidirectional, or two-way grip, or multidirectional folder.
Embodiment 3：As viewed in figures 5-8, it is preceding dilution filtration pattern, when to filter pattern, displacement liquid/dialysis fluid container
Commonly referred to as replace liquid container；Exogenous displacement liquid/dialysis fluid container is commonly referred to as exogenous displacement liquid container, displacement liquid with thoroughly
Analysis liquid is identical liquid, and simply liquid is inputted by hollow fiber dialyzer advance blood vessel road in the first fluid circulation system
Into blood, and non-input is to hollow dialysis dialyzer displacement liquid/dialyzate arrival end.
A kind of discontinuous CRRT machine capability bascules, including by enter blood vessel road 1, blood pump 2, hollow fiber dialyzer 3,
The blood circulation system that blood back pipeline 4 forms, by hollow fiber dialyzer 3, drain pipe road 5, the first tripper 6, liquid pump
7th, liquid container 8 is replaced, the first fluid circulation system that liquid back pipe road 9 forms, the first fluid circulation system makes with blood circulation system
With common hollow fiber dialyzer 3, the blood in blood circulation system passes through with the displacement liquid in the first fluid circulation system
Common hollow fiber dialyzer 3 carries out solute exchange, and hollow fiber dialyzer 3 includes blood inlet 10, blood outlet 11, put
Change liquid outlet 12, displacement liquid entrance 13；
It is described enter blood vessel road 1 one end introduce patient vessel after, by blood pump 2 through the other end couple hollow fiber dialyzer
3 blood inlet 10, the blood outlet 11 of one end connection hollow fiber dialyzer 3 of the blood back pipeline 4, the other end is by blood
Feed back patient's body；
One end connection displacement liquid entrance 12 of hollow fiber dialyzer 3 on the drain pipe road 5 or displacement liquid outlet 13, if connection
Displacement liquid entrance 13 is connect, then by the closing of displacement liquid outlet 13, if connecing displacement liquid outlet 13, displacement liquid entrance 12 is closed., lead to
After crossing the first tripper 6, liquid pump 7, the entrance of connection displacement liquid container 8, one end connection displacement liquid on the liquid back pipe road 9
The outlet of container 8, by coupling after the first tripper 6 into blood vessel road 1.
Also include by exogenous displacement liquid container 14, exogenous displacement liquid container drain pipe road 15, the second tripper 16,
Liquid pump 7, displacement liquid container 8, the second liquid circulatory system of the exogenous composition of displacement liquid container liquid back pipe road 19, the external source
Property displacement liquid container drain pipe road 15 drawn from exogenous displacement liquid container 14, occupy the by coupling after the second tripper 16
On drain pipe road 5 between one tripper 6 and liquid pump 7, described exogenous one end of displacement liquid container liquid back pipe road 19 is from putting
After changing the extraction of the liquid back pipe road 9 under liquid container 8, the other end is fed back in exogenous displacement liquid container 14 through the second tripper 16；
When the first tripper 6 is open-minded, and the second tripper 16 is closed, the displacement liquid container 8, hollow fibre dialysis
The first fluid circulation system that device 3, drain pipe road 5, liquid back pipe road 9 form is fixed into closed fluid circulation system, volume；
When the first tripper 6 is closed, and the second tripper 16 is opened, it is described by exogenous displacement liquid container 14, it is outer
Source property displacement liquid container drain pipe road 15, displacement liquid container 8, the second liquid of the exogenous composition of displacement liquid container liquid back pipe road 19
The circulatory system turns into open fluid circulation system, and the exogenous displacement liquid container 14 is replaceable.
As shown in Figure 7,8, it is additionally provided with the front end on drain pipe road 5 by ultrafiltration pipeline 20, ultrafiltrate pump 21,22 groups of ultrafiltration container
Into ultrafiltration system.
The ultrafiltration system also includes flow-monitoring device, and the flow-monitoring device is arranged on ultrafiltration pipeline 20, right
Flow rate of liquid and flow in ultrafiltration pipeline 20 are monitored.
The tripper 16 of first tripper 6 and second is tubing clamp.
The tripper 16 of first tripper 6 and second links, and is opened and is closed by CRRT machine coordinated signals, when
When CRRT machines open the first tripper 6, the linkage of the second tripper 16 is closed, the first fluid circulation system and blood circulation
System carries out mass exchange in hollow fiber dialyzer 3；When CRRT the first trippers 6 of machine switched off, the second open circuit dress
It is open-minded to put 16 linkages, the second liquid circulatory system is operated, the first fluid circulation system work in displacement liquid/dialysis fluid container 8
Waste liquid caused by work enters circulation in the second liquid circulatory system, dilution, feeds back to exogenous displacement liquid/dialysis fluid container 14
It is interior.
As shown in Fig. 6,8, first tripper 6 has 2, respectively on drain pipe road 5, liquid back pipe road 9, linkage
To drain pipe road 5, liquid back pipe road 9 closed, Open control；Second tripper 16 has 2, respectively positioned at exogenous displacement
On liquid container drain pipe road 15, exogenous displacement liquid container liquid back pipe road 19, linkage exogenous displacement liquid container drain pipe road
15th, exogenous displacement liquid container liquid back pipe road 19 closed, Open control.
It is 100-500ml that first fluid circulation system, which exchanges volume,.
The tubing clamp presss from both sides to be unidirectional, or two-way grip, or multidirectional folder.
Embodiment 4：As shown in figs9-12, be dialysis mode, when for dialysis mode when, displacement liquid/dialysis fluid container is usual
Referred to as dialysis fluid container；Exogenous displacement liquid/dialysis fluid container is commonly referred to as exogenous dialysis fluid container, displacement liquid and dialyzate
For identical liquid, the container for containing the liquid is also identical container.
A kind of discontinuous CRRT machine capability bascules, including by enter blood vessel road 1, blood pump 2, hollow fiber dialyzer 3,
The blood circulation system that blood back pipeline 4 forms, by hollow fiber dialyzer 3, drain pipe road 5, the first tripper 6, liquid pump
7th, the first fluid circulation system that dialysis fluid container 8, liquid back pipe road 9 form, the first fluid circulation system make with blood circulation system
With common hollow fiber dialyzer 3, the blood in blood circulation system passes through with the displacement liquid in the first fluid circulation system
Common hollow fiber dialyzer 3 carries out solute exchange, and hollow fiber dialyzer 3 includes blood inlet 10, blood outlet 11, thoroughly
Analyse liquid outlet 12, dialyzate entrance 13；
It is described enter blood vessel road 1 one end introduce patient vessel after, by blood pump 2 through the other end couple hollow fiber dialyzer
3 blood inlet 10, the blood outlet 11 of one end connection hollow fiber dialyzer 3 of the blood back pipeline 4, the other end is by blood
Feed back patient's body；
The dialyzate outlet 12 of one end connection hollow fiber dialyzer 3 on the drain pipe road 5, passes through the first tripper
6th, after liquid pump 7, couple the entrance of dialysis fluid container 8, the outlet of one end connection dialysis fluid container 8 on the liquid back pipe road 9, lead to
Couple the end of dialyzate entrance 13 after crossing the first tripper 6；
Also include by exogenous dialysis fluid container 14, exogenous dialysis fluid container drain pipe road 15, the second tripper 16,
Liquid pump 7, dialysis fluid container 8, the second liquid circulatory system of exogenous dialysis fluid container liquid back pipe road 19 composition, the external source
Property dialysis fluid container drain pipe road 15 drawn from exogenous dialysis fluid container 14, occupy the by coupling after the second tripper 16
On drain pipe road 5 between one tripper 6 and liquid pump 7, described exogenous one end of dialysis fluid container liquid back pipe road 19 is from saturating
After analysing the extraction of liquid back pipe road 9 under liquid container 14, the other end is fed back in exogenous dialysis fluid container 14 through the second tripper 16；
When the first tripper 6 is open-minded, and the second tripper 16 is closed, the dialysis fluid container 8, hollow fibre dialysis
The first fluid circulation system that device 3, drain pipe road 5, liquid back pipe road 9 form is fixed into closed fluid circulation system, volume；
When the first tripper 6 is closed, and the second tripper 16 is opened, it is described by exogenous dialysis fluid container 14, it is outer
Source property dialysis fluid container drain pipe road 15, dialysis fluid container 8, the second liquid of exogenous dialysis fluid container liquid back pipe road 19 composition
The circulatory system turns into open fluid circulation system, and the exogenous dialysis fluid container 14 is replaceable.
As shown in Figure 11,12, it is additionally provided with the front end on drain pipe road 5 by ultrafiltration pipeline 20, ultrafiltrate pump 21, ultrafiltration container 22
The ultrafiltration system of composition.
The ultrafiltration system also includes flow-monitoring device, and the flow-monitoring device is arranged on ultrafiltration pipeline 20, right
Flow rate of liquid and flow in ultrafiltration pipeline are monitored.
The tripper 16 of first tripper 6 and second is tubing clamp.
The tripper 16 of first tripper 6 and second links, and is opened and is closed by CRRT machine coordinated signals, when
When CRRT machines open the first tripper 6, the linkage of the second tripper 16 is closed, the first fluid circulation system and blood circulation
System carries out mass exchange in hollow fiber dialyzer 3；When CRRT the first trippers 6 of machine switched off, the second open circuit dress
It is open-minded to put 16 linkages, the second liquid circulatory system is operated, and is produced when first fluid circulation system works in dialysis fluid container 8
Waste liquid enter the second liquid circulatory system in circulation, dilution, feed back to it is exogenous displacement liquid container 14 in.
As shown in Fig. 9,12, first tripper 6 has 2, respectively on drain pipe road 5, liquid back pipe road 9, connection
It is dynamic to drain pipe road 5, liquid back pipe road 9 closed, Open control；Second tripper 16 has 2, respectively positioned at exogenous
On analysis liquid container drain pipe road 15, exogenous dialysis fluid container liquid back pipe road 19, link exogenous dialysis fluid container drain pipe
Road 15, exogenous dialysis fluid container liquid back pipe road 19 are closed, Open control.
Claims (8)
1. a kind of discontinuous CRRT machine capability bascules, including by entering blood vessel road, blood pump, hollow fiber dialyzer, blood back
Pipeline composition blood circulation system, by hollow fiber dialyzer, drain pipe road, the first tripper, liquid pump, displacement liquid/
First fluid circulation system of dialysis fluid container, liquid back pipe road composition, the first fluid circulation system use with blood circulation system
Common hollow fiber dialyzer, displacement liquid/dialyzate in blood and the first fluid circulation system in blood circulation system
Solute exchange is carried out by common hollow fiber dialyzer, hollow fiber dialyzer includes blood inlet, blood outlet, displacement
Liquid/dialyzate outlet, displacement liquid/dialyzate entrance；
It is described enter blood vessel road one end connection patient vessel after, pass through blood pump through the other end couple hollow fiber dialyzer blood
Import, the blood outlet of one end connection hollow fiber dialyzer of the blood back pipeline, the other end is by blood recovery patient's body；
It is characterized in that：Displacement liquid/dialyzate port of export of one end connection hollow fiber dialyzer on the drain pipe road, connection
After the first tripper, liquid pump, couple the entrance of displacement liquid/dialysis fluid container, one end connection on the liquid back pipe road
The outlet of displacement liquid/dialysis fluid container, by directly coupling blood back pipeline after the first tripper or entering blood vessel road, or connection is put
Change liquid/dialyzate arrival end；
Under forward and backward dilution filtration pattern, displacement liquid/dialyzate of one end connection hollow fiber dialyzer on the drain pipe road goes out
Mouth end, then seal the corresponding displacement liquid of hollow fiber dialyzer/dialyzate arrival end；One end connection on the drain pipe road
The displacement liquid of hollow fiber dialyzer/dialyzate arrival end, then the corresponding displacement liquid/dialyzate of hollow fiber dialyzer is gone out
The sealing of mouth end；
Under dialysis mode, displacement liquid/dialyzate port of export of the drain pipe road connection hollow fiber dialyzer, the liquid back pipe
Road couples displacement liquid/dialyzate arrival end of hollow fiber dialyzer；
Also include by exogenous displacement liquid/dialysis fluid container, exogenous displacement liquid/dialysis fluid container drain pipe road, the second open circuit
The second liquid of device, liquid pump, displacement liquid/dialysis fluid container, exogenous displacement liquid/dialysis fluid container liquid back pipe road composition follows
Loop system, the exogenous displacement liquid/dialysis fluid container drain pipe road are drawn from exogenous displacement liquid/dialysis fluid container, passed through
Connection is occupy on the drain pipe road between the first tripper and liquid pump after second tripper, and the exogenous displacement liquid/
Dialysis fluid container liquid back pipe road one end is after the liquid back pipe pass under displacement liquid/dialysis fluid container goes out, and the other end is through the second open circuit
Device feeds back exogenous displacement liquid/dialysis fluid container；
When the second tripper is closed, when the first tripper is opened, the displacement liquid/dialysis fluid container, hollow fibre are dialysed
Device, drain pipe road, the first fluid circulation system of liquid back pipe road composition are fixed into closed fluid circulation system, volume；
It is described by exogenous displacement liquid/dialysis fluid container, external source when the second tripper is opened when the closing of the first tripper
Property displacement liquid/dialysis fluid container drain pipe road, displacement liquid/dialysis fluid container, exogenous displacement liquid/dialysis fluid container liquid back pipe road
The second liquid circulatory system of composition turns into open fluid circulation system, and the exogenous displacement liquid/dialysis fluid container can be more
Change.
2. discontinuous CRRT machine capability bascules according to claim 1, it is characterised in that：Before liquid back pipe road
End is additionally provided with the ultrafiltration system being made up of ultrafiltration pipeline, ultrafiltrate pump, ultrafiltration container.
3. discontinuous CRRT machine capability bascules according to claim 2, it is characterised in that：The ultrafiltration system is also
Including flow-monitoring device, the flow-monitoring device is arranged on ultrafiltration pipeline, to the flow rate of liquid and stream in ultrafiltration pipeline
Amount is monitored.
4. discontinuous CRRT machine capability bascules according to claim 1, it is characterised in that：The first open circuit dress
It is tubing clamp to put with the second tripper.
5. discontinuous CRRT machine capability bascules according to claim 1, it is characterised in that：The first open circuit dress
Put and linked with the second tripper, opened and closed by CRRT machine coordinated signals, when CRRT machines open the first tripper
When, the linkage of the second tripper is closed, and the first fluid circulation system is carried out with blood circulation system in hollow fiber dialyzer
Mass exchange；When CRRT the first trippers of machine switched off, the linkage of the second tripper is open-minded, and the second liquid circulatory system is entered
Row work, waste liquid caused by the work of the first fluid circulation system enters second liquid cyclic system in displacement liquid/dialysis fluid container
Circulation, dilution, feed back in exogenous displacement liquid/dialysis fluid container in system.
6. discontinuous CRRT machine capability bascules according to claim 1, it is characterised in that：The first open circuit dress
2 are equipped with, respectively on drain pipe road, liquid back pipe road, is linked to drain pipe road, liquid back pipe road is closed, Open control；
Second tripper has 2, respectively positioned at exogenous displacement liquid/dialysis fluid container drain pipe road, exogenous displacement liquid/dialyzate
On container liquid back pipe road, linkage exogenous displacement liquid/dialysis fluid container drain pipe road, exogenous displacement liquid/dialysis fluid container
Liquid back pipe road is closed, Open control.
7. discontinuous CRRT machine capability bascules according to claim 1, it is characterised in that：First liquid circulation system
It is 100-500ml that system, which exchanges volume,.
8. discontinuous CRRT machine capability bascules according to claim 4, it is characterised in that：The tubing clamp is single
To folder or multidirectional folder.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610059234.2A CN105597176B (en) | 2016-01-28 | 2016-01-28 | A kind of discontinuous CRRT machine capability bascules |
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| CN201610059234.2A CN105597176B (en) | 2016-01-28 | 2016-01-28 | A kind of discontinuous CRRT machine capability bascules |
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Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2142981T3 (en) * | 1994-09-02 | 2000-05-01 | Terumo Corp | DIALIZER. |
| JP4129726B2 (en) * | 2002-07-17 | 2008-08-06 | ニプロ株式会社 | Peritoneal dialysis machine |
| CN2810611Y (en) * | 2005-06-22 | 2006-08-30 | 浙江科锐生物科技有限公司 | In-vitro artificial liver support system |
| CN201033178Y (en) * | 2007-04-05 | 2008-03-12 | 苏州大学附属第一医院 | Novel external artificial liver supporting and treating system |
| DE102009058681A1 (en) * | 2009-12-16 | 2011-06-22 | Fresenius Medical Care Deutschland GmbH, 61352 | Balancing device, external medical functional device, treatment device and method |
| JPWO2013175896A1 (en) * | 2012-05-25 | 2016-01-12 | ニプロ株式会社 | Dialysis unit |
| CN203989201U (en) * | 2014-08-15 | 2014-12-10 | 中国人民解放军第三军医大学第二附属医院 | A kind of based on Diapact CRRT machine and for the improved device of Cured by Double Filtration Plasmapheresis plasmapheresis |
| CN104971391A (en) * | 2015-06-19 | 2015-10-14 | 南方医科大学珠江医院 | Novel combined type liver and kidney support system CRRT mode tube |
| CN205649684U (en) * | 2016-01-28 | 2016-10-19 | 龚德华 | Discontinuous CRRT machine capacity balancing unit |
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2016
- 2016-01-28 CN CN201610059234.2A patent/CN105597176B/en not_active Expired - Fee Related
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