CN203989201U - A kind of based on Diapact CRRT machine and for the improved device of Cured by Double Filtration Plasmapheresis plasmapheresis - Google Patents
A kind of based on Diapact CRRT machine and for the improved device of Cured by Double Filtration Plasmapheresis plasmapheresis Download PDFInfo
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- CN203989201U CN203989201U CN201420463361.5U CN201420463361U CN203989201U CN 203989201 U CN203989201 U CN 203989201U CN 201420463361 U CN201420463361 U CN 201420463361U CN 203989201 U CN203989201 U CN 203989201U
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Abstract
The utility model discloses a kind ofly based on Diapact CRRT machine and for the improved device of Cured by Double Filtration Plasmapheresis plasmapheresis, comprise blood pump, tremulous pulse kettle, plasma separator, the first Medical tee joint interface, waste drains pump, cascadeflow, waste liquid bag, displacement liquid pump, venous chambers, the second Medical tee joint joint, waste liquid pressure transducer PD
2, arterial pressure sensor PA, venous pressure sensor PV, filter before pressure transducer PBE, displacement liquid pressure transducer PD
1, leak blood sensor, displacement liquid air bubble sensor, the first folder valve, heater, the second folder valve, the 3rd folder valve, the 4th folder valve and blood, air bubble sensor.This utility model is by newly treating the development and application of pattern to the bright Diapact CRRT of German shellfish machine, in the hardware and software situation that does not change existing equipment, realize the function that the special blood purification treatment device of minority just can carry out DFPP treatment, meet clinical needs, saved the expense of buying again special equipment.
Description
Technical field
This utility model relates to medical apparatus and instruments and manufactures field, particularly relates to a kind of based on Diapact CRRT machine and for the improved device of Cured by Double Filtration Plasmapheresis plasmapheresis.
Background technology
Plasmapheresis be the blood plasma of separation is all abandoned and with fresh blood plasma substitute, but the factors such as the propagation of the shortage of blood plasma, blood borne disease are restricted this method.
Cured by Double Filtration Plasmapheresis plasmapheresis (double filtration plasmapheresis, be called for short DFPP) be by the pathogenic blood plasma after flash trapping stage is carried out to the second-order separation, then by the blood plasma after reject virulence factor and blood formed element together in defeated ex vivo, thereby reach a kind of selectivity separating plasma therapy for the treatment of disease object.It carries out after secondary filter, what abandon is only the macro-molecular protein (as immunoglobulin) of again separating, and small molecular protein (as albumin) is understood again in defeated ex vivo, features such as DFPP is at the technical new technique growing up of membrane plasma separation, and that the relative plasma exchange method of this technology has is safe, applied widely, nutrient substance is lost less, blood plasma use amount is few! The critical treatment means of clinical multiple subjects are become at present.As very extensive in the application of the subjects such as disease in the blood system, kidney disease, knot single tissue disease.
The multifunctional all Continuous Blood Purification device of Diapact CRRT apparatus for purifying blood Shi Beilang company development, can be used for intermittently or continuous blood purification treatment, comprise slow continuous ultrafiltration (SCUF), the quiet venous hemofiltration of seriality (CVVH), the seriality arteries and veins hemodialysis silently (various modes such as CVVHD, hemoperfusion (HP) and plasmapheresis (PE).Its design feature is that each treatment pattern is same machine operation, uses different consumptive materials for the setting of parameter and the demonstration of therapeutic state.As shown in Figures 1 and 2, along with the development of CRRT technology, can find by contrast, CVVH and DFPP have certain similarity in design principle, are all to leach blood plasma or ultrafiltrate by membrane separator, then discard waste liquid.Our object is not change under Diapact CRRT apparatus for purifying blood hardware case, blood pump is remained unchanged as the blood pump of DFPP, using waste drains pump as a point stock pump, return to using displacement liquid pump as the isolated blood plasma of second-stage separator to the stock pump that returns of blood, utilize arranging of net ultrafiltration to realize the eliminating of waste liquid, and waste liquid adopt its speed of folder valve control, finally by the suitable variation of pipeline connecting mode process, by the expansion to original treatment, realize preferably the treatment of DFPP.
In addition, under CVVH treatment pattern, there are five pressure detectors, are respectively arterial pressure sensor (PA), venous pressure sensor (PV), the front pressure transducer (PBE) of filter, displacement liquid pressure transducer (PD
1), waste liquid pressure transducer (PD
2), simultaneously according to PV, PBE and PD
2machine can calculate transmembrane pressure (TMP) and the filter pressure drop (PFD) of filter automatically, judges that by TMP and PFD the blood coagulation situation of filter is more accurate.But owing to having newly increased a cascadeflow in DFPP treatment pattern, its transmembrane pressure monitoring can be under some influence.
The patent No. is that 201220375723.6 Chinese utility model patent discloses a kind of CRRT of improvement machine for carrying out the combination unit of double plasma filtration, it is mainly to expand and improve on existing CRRT machine PEX treatment pattern basis, having set up a point of stock pump, a cascadeflow, a Medical tee joint interface and pipeline that some are suitable connects, reality to will carrying out secondary filtration containing the blood plasma of virulence factor after flash trapping stage, by the together a kind of selectivity separating plasma therapy in defeated ex vivo of the blood plasma after reject virulence factor and blood formed element.Be provided with a point of stock pump but increase, make structure complicated, and a point stock pump is separate single pump, and between other pumps, do not possess concertedness, trivial operations, and do not consider and can make the pressure monitor of the cascadeflow of increase to treat safety and be under some influence.
Utility model content
The technical problem that this utility model mainly solves is to provide a kind of based on Diapact CRRT machine and for the improved device of Cured by Double Filtration Plasmapheresis plasmapheresis, by the bright Diapact CRRT of German shellfish machine newly being treated to the development and application of pattern, in the hardware and software situation that does not change existing equipment, realize the function that the special blood purification treatment device of minority just can carry out DFPP treatment, meet clinical needs, saved the expense of buying again special equipment.
For solving the problems of the technologies described above, the technical scheme that this utility model adopts is: provide a kind of based on Diapact CRRT machine and for the improved device of Cured by Double Filtration Plasmapheresis plasmapheresis, comprise blood pump, tremulous pulse kettle, plasma separator, the first Medical tee joint interface, waste drains pump, cascadeflow, waste liquid bag, displacement liquid pump, venous chambers, the second Medical tee joint joint, waste liquid pressure transducer, leak blood sensor, displacement liquid air bubble sensor, the first folder valve and blood, air bubble sensor;
One end of described blood pump connects patient's arterial line, the other end connects one end of tremulous pulse kettle, the other end of described tremulous pulse kettle connects the arterial end of plasma separator, the vein end pipeline of described plasma separator is connected with the first Medical tee joint interface, the vein end bypass of described plasma separator is connected with waste drains pump, described waste drains pump is connected with cascadeflow arterial end pipeline, described cascadeflow vein end pipeline is connected with waste liquid bag, the bypass of described cascadeflow vein end is connected with displacement liquid pump, described displacement liquid pump is connected with one end of venous chambers by the first Medical tee joint interface, the other end of described venous chambers connects patient's venous line,
Pipeline between the bypass of described plasma separator vein end and waste drains pump is provided with the second Medical tee joint joint, on the pipeline that the intermediate ends of described the second Medical tee joint joint connects, is provided with waste liquid pressure transducer; On pipeline between the vein end bypass of described plasma separator and the second Medical tee joint joint, Lou blood sensor is set; On pipeline between the bypass of described cascadeflow vein end and displacement liquid pump, be provided with displacement liquid air bubble sensor; In the venous line that described venous chambers is connected with patient, be provided with blood, air bubble sensor; On pipeline between the vein end of described cascadeflow and waste liquid bag, be provided with the first folder valve.
Further, the pipeline between described arterial line and the arrival end of blood pump is provided with arterial pressure sensor.
Further, the pipeline between the vein end of described tremulous pulse kettle and the arterial end of plasma separator is provided with the front pressure transducer of filter.
Further, on the pipeline between described waste drains pump and cascadeflow arterial end, be provided with displacement liquid pressure transducer.
Further, on described venous chambers, be connected with venous pressure sensor.
Further, on the pipeline between described displacement liquid pump and the first Medical tee joint interface, be provided with heater.
Further, in the bypass of described plasma separator arterial end, be provided with the second folder valve.
Further, in the venous line that described blood, air bubble sensor are connected with patient, be provided with the 3rd folder valve.
Further, in the bypass of described cascadeflow arterial end, be provided with the 4th folder valve.
This utility model has been set up a cascadeflow, two Medical tee joint interfaces and suitable pipeline and has been connected on existing Diapact CRRT machine, when will utilizing cascadeflow to carry out secondary filtration containing the blood plasma of the factor of curing the disease after flash trapping stage, secondary membrane filtration is supplemented as displacement liquid except the blood plasma after virulence factor, and last and blood formed element is together in defeated time patient body; Waste liquid pressure transducer is connected on the pipeline between the bypass of plasma separator vein end and waste drains pump by Medical tee joint interface, can make machine show the situation of transmembrane pressure (TMP) and filter pressure drop (PFD) reflection plasma separator more accurate, displacement liquid pressure transducer, for monitoring front pressure of filter of cascadeflow, can reflect its blood coagulation situation indirectly simultaneously; This device is not only safe, and blood plasma consumption is few, has avoided the propagation of blood borne disease, and few intercurrent disease, is widely used, and this device is simple in structure, easy to operate, cost-saving.
Brief description of the drawings
Fig. 1 is the schematic diagram of CVVH treatment pattern.
Fig. 2 is the schematic diagram of DFPP treatment pattern.
Fig. 3 is that this utility model is a kind of based on Diapact CRRT machine and for the schematic diagram of the improved device of Cured by Double Filtration Plasmapheresis plasmapheresis.
Detailed description of the invention
Below in conjunction with drawings and Examples, further set forth this utility model.In the following detailed description, only by the mode of explanation, some example embodiment of the present utility model has been described.Undoubtedly, those of ordinary skill in the art can recognize, in the situation that not departing from spirit and scope of the present utility model, can revise described embodiment by various mode.Therefore, accompanying drawing is illustrative with being described in essence, instead of for limiting the protection domain of claim.
The equipment using in the present embodiment has Bei Lang Diapact CRRT machine and supporting CVVH treatment pattern pipeline, the OP-08W of Asahi Chemical Industry plasma separator (membrane area 0.8m
2, membrane aperture 0.3 μ m), the EC-50W/EC-40W/EC-30W/EC20W of Asahi Chemical Industry cascadeflow (membrane area 2.0m
2, membrane aperture be respectively 0.035 μ m/0.03 μ m/0.02 μ m/0.01 μ m), Medical tee joint interface.
Please refer to shown in Fig. 3, this utility model is a kind of to be comprised based on Diapact CRRT machine and for the preferred embodiments of the improved device of Cured by Double Filtration Plasmapheresis plasmapheresis: blood pump 1, tremulous pulse kettle 12, plasma separator 5, the first Medical tee joint interface 21, waste drains pump 2, cascadeflow 6, waste liquid bag 23, displacement liquid pump 3, venous chambers 13, the second Medical tee joint joint 22, waste liquid pressure transducer PD
211, pressure transducer PBE9, displacement liquid pressure transducer PD before arterial pressure sensor PA7, venous pressure sensor PV8, filter
110, leak blood sensor 14, displacement liquid air bubble sensor 15, the first folder valve 4, heater 20, the second folder valve 17, the 3rd folder valve 18, the 4th folder valve 19 and blood, air bubble sensor 16.
One end of described blood pump 1 connects patient's arterial line, the other end connects one end of tremulous pulse kettle 12, the other end of described tremulous pulse kettle 12 connects the arterial end of plasma separator 5, the vein end pipeline of described plasma separator 5 is connected with the first Medical tee joint interface 21, the vein end bypass of described plasma separator 5 is connected with waste drains pump 2, described waste drains pump 2 is connected with cascadeflow 6 arterial end pipelines as a point stock pump, for isolated plasma separator 5 blood plasma is pumped into cascadeflow 6.Described cascadeflow 6 vein end pipelines are connected with waste liquid bag 23, described cascadeflow 6 vein end bypasses are connected with displacement liquid pump 3, described displacement liquid pump 3 is connected with one end of venous chambers 13 by the first Medical tee joint interface 21 as returning stock pump, for by blood plasma blowback vein end.The other end of described venous chambers 13 connects patient's venous line.
Specifically, shown in Fig. 2 and Fig. 3, the one-level plasma separator in DFPP treatment pattern adopts plasma separator 5, and described secondary plasma separator adopts cascadeflow 6.
Pipeline between described plasma separator 5 vein end bypasses and waste drains pump 2 is provided with the second Medical tee joint joint 22, on the pipeline that the intermediate ends of described the second Medical tee joint joint 22 connects, is provided with waste liquid pressure transducer PD
211; On pipeline between the vein end bypass of described plasma separator 5 and the second Medical tee joint joint 22, Lou blood sensor 14 is set; On pipeline between described cascadeflow 6 vein end bypasses and displacement liquid pump 3, be provided with displacement liquid air bubble sensor 15; In the venous line that described venous chambers 13 is connected with patient, be provided with blood, air bubble sensor 16; On pipeline between the vein end of described cascadeflow 6 and waste liquid bag 23, be provided with the first folder valve 4.
Pipeline between the arrival end of described arterial line and blood pump 1 is provided with arterial pressure sensor PA7.Pipeline between the arterial end of the vein end of described tremulous pulse kettle 12 and plasma separator 5 is provided with the front pressure transducer PBE9 of filter.On pipeline between described waste drains pump 2 and cascadeflow 6 arterial ends, be provided with displacement liquid pressure transducer PD
110.On described venous chambers 13, be connected with venous pressure sensor PV8.
On pipeline between described displacement liquid pump 3 and the first Medical tee joint interface 21, be provided with heater 20.
In described plasma separator 5 arterial end bypasses, be provided with the second folder valve 17.In the venous line that described blood, air bubble sensor 16 are connected with patient, be provided with the 3rd folder valve 18.In described cascadeflow 6 arterial end bypasses, be provided with the 4th folder valve 19.
The use step of this device is:
1. the selection for the treatment of pattern
Check that whether Diapact CRRT apparatus for purifying blood is intact, whether power supply is normal.Start, completes machine parameter self-inspection and self-inspection completely, selects CVVH treatment pattern.As shown in Figures 1 and 2, because CVVH treatment pattern and DFPP treatment pattern have certain similarity in design principle, be all to leach blood plasma or ultrafiltrate by membrane separator, then discard waste liquid.By contrasting two class therapeutic modalities, its common ground is: all need pressure monitor system accurately, bubble and leak blood monitoring component, perfect liquid-heating system and three driving pumps.Difference is: in 1.CVVH treatment pattern, only have a dialyser, and in DFPP treatment pattern, have two Membrane Plasma Separators; In 2.CVVH treatment pattern, needing to supplement displacement liquid, is that the blood plasma that secondary membrane filtration is removed supplements as displacement liquid in DFPP treatment pattern.Therefore, only need to increase a cascadeflow 6, then change a little pipeline connecting mode, can realize the function of DFPP treatment pattern.
2. the connection of pipeline and flushing
Please refer to shown in Fig. 3, stricter to the diameter requirement of pump line because of Diapact CRRT apparatus for purifying blood, therefore all pump lines all adopt a whole set of pipeline of German Bei Lang company special CVVH treatment pattern.According to CVVH treatment pattern, transducer potector is installed, film filter adopts one-level plasma separator.By the trident interface of waste liquid pipeline wherein one connect one-level plasma separator 5, other end connects waste drains pump 2, intermediate ends connects waste liquid pressure transducer 11, pump line is installed on waste drains pump 2, finally connect cascadeflow 6, its arterial end is connected to waste drains pump 2, and vein end connects waste liquid bag 23.Then the joint of displacement liquid pump 3 is connected in the vein end bypass of cascadeflow 6, finally displacement liquid pump 3 is connected to venous chambers through the first Medical tee joint interface 21.Finally open the folder of the 3rd on pipeline valve 18, close the first folder valve 4, the second folder valve 17 and the 4th folder valve 19, after the self-inspection of Diapact CRRT apparatus for purifying blood seal is passed through, then open the first folder valve 4 and carry out preliminary filling pipeline aerofluxus.Set up before extracorporeal circulation in preparation, close the first folder valve 4, after upper machine, adjusting size.The principle of its DFPP treatment pattern as shown in Figure 3.
3. the setting for the treatment of parameter
Connect before patient, treat parameter setting.Enter CVVH treatment mode parameter interface is set, it is 150-180ml/min that blood flow rate is set; Ultrafiltration volume (abandoning slurry amount) is 100-120ml/h, and its speed regulates by the first folder valve 4; Displacement liquid measure (being that secondary film returns slurry) is 1500ml/h, thereby point slurry amount can be according to abandoning slurry amount and return slurry amount the pump speed that automatically calculates and feed back to machine control waste drains pump 2.
4. the monitoring of every pressure parameter
Under CVVH treatment pattern, there are five pressure detectors, are respectively arterial pressure sensor (PA) 7, venous pressure sensor (PV) 8, the front pressure transducer (PBE) 9 of filter, displacement liquid pressure transducer (PD
1) 10, waste liquid pressure transducer (PD
2) 11, simultaneously according to PV8, PBE9 and PD
211 machines can calculate transmembrane pressure (TMP) and the filter pressure drop (PFD) of filter automatically, judge that by TMP and PFD the blood coagulation situation of filter is more accurate.But owing to having newly increased a cascadeflow 6 in DFPP treatment pattern, its transmembrane pressure monitoring is under some influence, and therefore the inventor is by waste liquid pressure transducer (PD
2) 11 be connected on the pipeline between plasma separator 5 vein ends and waste drains pump 2 by the second Medical tee joint interface 22, make and can make machine show transmembrane pressure (TMP) after so little change and filter pressure drop (PFD) reflects that the situation of plasma separator 5 is more accurate, while displacement liquid pressure transducer (PD
1) 10 be positioned at before cascadeflow 6 filters, indirectly reflect its blood coagulation situation, ensure the safety of cascadeflow 6.Other compression fittings does not make and changes.
5. the foundation of extracorporeal circulation and end
The foundation of extracorporeal circulation is identical with CVVH treatment pattern, treatment finishes blood flow to be adjusted to 50-80ml/min, blood end blood back is identical with CVVH pattern, that end that the second Medical tee joint interface 22 is connected with plasma separator 5 disconnects, then be communicated with normal saline, utilize waste drains pump 2 and displacement liquid pump 3 by blood plasma blowback vein end, i.e. blood end and blood plasma end blood back simultaneously, after blood plasma has returned, general blood back also completes.
Above specific descriptions of the present utility model are intended to illustrate the implementation of specific embodiments, can not be interpreted as it is to restriction of the present utility model, those skilled in the art are under instruction of the present utility model, can on the embodiment basis of describing in detail, make various variants, within these variants all should be included in design of the present utility model.This utility model scope required for protection only will be stated and be limited by described right.
Claims (9)
1. based on Diapact CRRT machine and for the improved device of Cured by Double Filtration Plasmapheresis plasmapheresis, it is characterized in that: comprise blood pump, tremulous pulse kettle, plasma separator, the first Medical tee joint interface, waste drains pump, cascadeflow, waste liquid bag, displacement liquid pump, venous chambers, the second Medical tee joint joint, waste liquid pressure transducer, leak blood sensor, displacement liquid air bubble sensor, the first folder valve and blood, air bubble sensor;
One end of described blood pump connects patient's arterial line, the other end connects one end of tremulous pulse kettle, the other end of described tremulous pulse kettle connects the arterial end of plasma separator, the vein end pipeline of described plasma separator is connected with the first Medical tee joint interface, the vein end bypass of described plasma separator is connected with waste drains pump, described waste drains pump is connected with cascadeflow arterial end pipeline, described cascadeflow vein end pipeline is connected with waste liquid bag, the bypass of described cascadeflow vein end is connected with displacement liquid pump, described displacement liquid pump is connected with one end of venous chambers by the first Medical tee joint interface, the other end of described venous chambers connects patient's venous line,
Pipeline between the bypass of described plasma separator vein end and waste drains pump is provided with the second Medical tee joint joint, on the pipeline that the intermediate ends of described the second Medical tee joint joint connects, is provided with waste liquid pressure transducer; On pipeline between the vein end bypass of described plasma separator and the second Medical tee joint joint, Lou blood sensor is set; On pipeline between the bypass of described cascadeflow vein end and displacement liquid pump, be provided with displacement liquid air bubble sensor; In the venous line that described venous chambers is connected with patient, be provided with blood, air bubble sensor; On pipeline between the vein end of described cascadeflow and waste liquid bag, be provided with the first folder valve.
2. according to claim 1 a kind of based on Diapact CRRT machine and for the improved device of Cured by Double Filtration Plasmapheresis plasmapheresis, it is characterized in that: the pipeline between described arterial line and the arrival end of blood pump is provided with arterial pressure sensor.
3. according to claim 1 a kind of based on Diapact CRRT machine and for the improved device of Cured by Double Filtration Plasmapheresis plasmapheresis, it is characterized in that: the pipeline between the vein end of described tremulous pulse kettle and the arterial end of plasma separator is provided with pressure transducer before filter.
4. according to claim 1 a kind of based on Diapact CRRT machine and for the improved device of Cured by Double Filtration Plasmapheresis plasmapheresis, it is characterized in that: on the pipeline between described waste drains pump and cascadeflow arterial end, be provided with displacement liquid pressure transducer.
5. according to claim 1 a kind of based on Diapact CRRT machine and for the improved device of Cured by Double Filtration Plasmapheresis plasmapheresis, it is characterized in that: on described venous chambers, be connected with venous pressure sensor.
6. according to claim 1 a kind of based on Diapact CRRT machine and for the improved device of Cured by Double Filtration Plasmapheresis plasmapheresis, it is characterized in that: on the pipeline between described displacement liquid pump and the first Medical tee joint interface, be provided with heater.
7. according to claim 1 a kind of based on Diapact CRRT machine and for the improved device of Cured by Double Filtration Plasmapheresis plasmapheresis, it is characterized in that: in the bypass of described plasma separator arterial end, be provided with the second folder valve.
8. according to claim 1 a kind of based on Diapact CRRT machine and for the improved device of Cured by Double Filtration Plasmapheresis plasmapheresis, it is characterized in that: in the venous line that described blood, air bubble sensor are connected with patient, be provided with the 3rd folder valve.
9. according to claim 1 a kind of based on Diapact CRRT machine and for the improved device of Cured by Double Filtration Plasmapheresis plasmapheresis, it is characterized in that: in the bypass of described cascadeflow arterial end, be provided with the 4th folder valve.
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| CN201420463361.5U CN203989201U (en) | 2014-08-15 | 2014-08-15 | A kind of based on Diapact CRRT machine and for the improved device of Cured by Double Filtration Plasmapheresis plasmapheresis |
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| CN201420463361.5U CN203989201U (en) | 2014-08-15 | 2014-08-15 | A kind of based on Diapact CRRT machine and for the improved device of Cured by Double Filtration Plasmapheresis plasmapheresis |
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| CN104984426A (en) * | 2015-07-07 | 2015-10-21 | 陈国军 | Novel CRRT return pipe |
| CN105597176A (en) * | 2016-01-28 | 2016-05-25 | 龚德华 | Intermittent CRRT (Continuous Renal Replacement Therapy) machine capacity balance device |
| CN105727382A (en) * | 2016-01-28 | 2016-07-06 | 龚德华 | Continuous type CRRT machine capacity balancing device with two circuit breaking devices |
| CN105879138A (en) * | 2016-06-11 | 2016-08-24 | 赵晓玲 | Extracorporeal circulation pipeline of plasma exchange device capable of switching blood separators |
| CN107366644A (en) * | 2016-05-13 | 2017-11-21 | 弗雷森纽斯医疗护理德国有限责任公司 | Dialysis machine with actuator and hydraulic system |
| CN111068134A (en) * | 2019-12-31 | 2020-04-28 | 周红卫 | Blood purifier without dialysate |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104984426A (en) * | 2015-07-07 | 2015-10-21 | 陈国军 | Novel CRRT return pipe |
| CN105597176A (en) * | 2016-01-28 | 2016-05-25 | 龚德华 | Intermittent CRRT (Continuous Renal Replacement Therapy) machine capacity balance device |
| CN105727382A (en) * | 2016-01-28 | 2016-07-06 | 龚德华 | Continuous type CRRT machine capacity balancing device with two circuit breaking devices |
| CN107366644A (en) * | 2016-05-13 | 2017-11-21 | 弗雷森纽斯医疗护理德国有限责任公司 | Dialysis machine with actuator and hydraulic system |
| CN107366644B (en) * | 2016-05-13 | 2021-04-02 | 弗雷森纽斯医疗护理德国有限责任公司 | Dialysis machine with actuator and hydraulic system |
| CN105879138A (en) * | 2016-06-11 | 2016-08-24 | 赵晓玲 | Extracorporeal circulation pipeline of plasma exchange device capable of switching blood separators |
| CN111068134A (en) * | 2019-12-31 | 2020-04-28 | 周红卫 | Blood purifier without dialysate |
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