CN111068134A

CN111068134A - Blood purifier without dialysate

Info

Publication number: CN111068134A
Application number: CN201911408359.1A
Authority: CN
Inventors: 周红卫; 周静妍; 史应龙; 汤宏群; 吴卓媚; 代与择
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-12-31
Filing date: 2019-12-31
Publication date: 2020-04-28

Abstract

The invention relates to the technical field of medical equipment, and particularly discloses a dialysate-free blood purifier, which comprises: hemofilter, blood purifier, venous pot, blood pump, first accuse flow force (forcing) pump, second accuse flow force (forcing) pump and waste liquid bag. The blood in the human blood vessel is introduced into a blood filter through a blood pump, part of primary filtrate containing water, electrolyte, trace elements and various middle and small molecular metabolic wastes is separated, the primary filtrate is injected into a blood purifier through a flow control pressure pump and then is separated into secondary filtrate containing water and electrolyte ions and waste liquid containing various middle and small molecular metabolic wastes, and the secondary filtrate and the blood flowing through the blood filter are converged through a venous pot and then are infused into the human venous blood vessel; the waste liquid is discharged into a waste liquid bag. The purifier does not need to use dialysate or replacement fluid, is safe and reliable, has definite curative effect and small side effect, is the basis of integration and portability in the future, has infinite and wide prospect, and is an important milestone for blood purification.

Description

Blood purifier without dialysate

Technical Field

The invention belongs to the technical field of medical equipment, and particularly relates to a blood purifier without dialysate.

Background

Uremia is a clinical syndrome that occurs at the end stage of renal failure. Hemodialysis is a commonly used method for treating uremia, can effectively maintain the life of uremia patients, and has the principle that the blood and dialysate of patients are simultaneously introduced into a dialyzer (artificial kidney) by utilizing the bidirectional separation effect of a semipermeable membrane, flow in opposite directions on two sides of a dialysis membrane, and remove high-concentration metabolites and toxins by means of dispersion and convection by virtue of solute gradient, osmotic gradient and water pressure gradient on two sides of the membrane, so as to supplement required substances and correct electrolyte and acid-base balance disorder. However, a large amount of dialysate is needed in the hemodialysis process, the components of the existing dialysate are very simple, the dialysis can aggravate the lack of trace elements due to the essential trace elements in inorganic bodies, the hemodialysis machine has a complex structure and a large volume, and when a patient carries out hemodialysis treatment, the hemodialysis efficiency is far higher than the efficiency of a human kidney, so that the unbalanced state of severe change of the internal environment of the human body can be caused in a short time, and various risks are caused; and when hemodialysis treatment is carried out, the patient needs to go to a designated place and is treated by using fixed equipment, so that the patient cannot carry the patient, and the life and the work are seriously influenced.

Disclosure of Invention

The invention aims to provide a blood purifier without dialysate, so as to overcome the defects that the existing hemodialysis machine needs dialysate, is unbalanced due to drastic change of internal environment caused by high efficiency, is inconvenient to carry and use, and seriously influences life and work.

To achieve the above object, the present invention provides a dialysate-free blood purifier, comprising: a hemofilter provided with a blood inlet, a blood outlet and a filtrate outlet; the blood purifier is provided with a purifier filtrate inlet, the purifier filtrate inlet is connected with the filtrate outlet, and the blood purifier is also provided with a waste liquid outlet and a purified liquid outlet; the venous pot is provided with a first inlet and a second inlet, the first inlet is connected with the blood outlet, the second inlet is connected with the purified liquid outlet, and a venous pot outlet is formed in the venous pot; and the blood pump is provided with a blood pump inlet and a blood pump outlet, and the blood pump outlet is connected with the blood inlet.

Preferably, in the above technical solution, the filtrate outlet is connected to the filtrate inlet of the purifier through a first flow control pressurizing pump.

Preferably, in the above technical scheme, the waste liquid outlet is connected with a waste liquid bag.

Preferably, in the above technical solution, the purified liquid outlet is connected to the second inlet through a second flow control pressurization pump.

Preferably, in the above technical solution, a waste liquid chamber and a purification chamber are provided inside the blood purifier, the waste liquid chamber is respectively communicated with the purifier filtrate inlet and the waste liquid outlet, the purification chamber is communicated with the purification liquid outlet, and a high-density filter membrane is provided between the waste liquid chamber and the purification chamber.

Preferably, in the above technical scheme, a filtration chamber is arranged in the hemofilter, a filtration channel is arranged in the filtration chamber, two ends of the filtration channel are respectively communicated with the blood inlet and the filtrate outlet, and the filtration chamber and the filtrate outlet are communicated with each other.

Preferably, in the above technical solution, the channel wall of the filtration channel is a high-flux filtration membrane.

Preferably, in the above technical scheme, a mixing chamber is arranged in the venous pot and is respectively communicated with the first inlet, the second inlet and the outlet of the venous pot.

Preferably, in the above-described aspect, after the filtration by the hemofilter, the amount of the effluent at the filtrate outlet is 30% of the amount of the influent at the blood inlet.

Compared with the prior art, the invention has the following beneficial effects:

1. the hemofilter can filter out liquid with 30 percent of the filtering flow of blood flowing through the hemofilter, the filtered filtrate is separated and purified by a blood purifier to generate secondary filtrate only containing water and electrolyte and waste liquid containing middle and small molecular metabolites, the purified secondary filtrate and the blood flowing through the hemofilter are converged in a venous kettle and are infused back to a human body through a blood pipeline without using dialysate and replacement liquid.

2. The blood purifier is safe and reliable, has definite curative effect, small side effect and simple and compact structure, is the basis for integrating and carrying in the future, has infinite and wide prospect, and is an important milestone for blood purification.

Drawings

FIG. 1 is a schematic diagram of a dialysate-free blood purifier of the present invention.

Fig. 2 is a sectional view of the blood purifier.

Fig. 3 is a sectional view of the hemofilter.

Figure 4 is a cross-sectional view of the intravenous drip.

Description of the main reference numerals:

1-hemofilter, 2-blood purifier, 3-venous pot, 4-blood pump, 5-first flow control pressure pump, 6-waste liquid bag, 7-second flow control pressure pump, 8-first conduit, 9-second conduit, 11-blood outlet, 12-filtrate outlet, 13-blood inlet, 14-filtration chamber, 15-filtration channel, 16-high-flux filtration membrane, 21-purifier filtrate inlet, 22-waste liquid outlet, 23-purified liquid outlet, 24-purification chamber, 25-waste liquid chamber, 26-high density filter membrane, 31-first inlet, 32-second inlet, 33-venous pot outlet, 34-mixing chamber, 41-blood pump inlet, 42-blood pump outlet.

Detailed Description

The following detailed description of the present invention is provided in conjunction with the accompanying drawings, but it should be understood that the scope of the present invention is not limited to the specific embodiments.

As shown in fig. 1 to 4, the blood purifier without dialysate in this embodiment includes: the device comprises a hemofilter 1, a blood purifier 2, a venous pot 3, a blood pump 4, a first flow control pressurization pump 5, a waste liquid bag 6, a second flow control pressurization pump 7, a first conduit 8, a second conduit 9, a blood outlet 11, a filtrate outlet 12, a blood inlet 13, a filtration cavity 14, a filtration channel 15, a high-flux filtration membrane 16, a purifier filtrate inlet 21, a waste liquid outlet 22, a purified liquid outlet 23, a purification chamber 24, a waste liquid chamber 25, a high-density filtration membrane 26, a first inlet 31, a second inlet 32, a venous pot outlet 33, a mixing cavity 34, a blood pump inlet 41 and a blood pump outlet 42. The hemofilter 1 is provided with a blood outlet 11, a filtrate outlet 12 and a blood inlet 13, the blood inlet 13 is connected with a blood pump outlet 42 of the blood pump 4, a blood pump inlet 41 of the blood pump 4 is connected with one end of the first conduit 8, and the other end of the first conduit 8 is communicated with an arterial blood vessel of a human body. A mixing cavity 34 is arranged in the venous pot 3, the top of the mixing cavity 34 is provided with a first inlet 31 and a second inlet 32, and the bottom of the mixing cavity is provided with a venous pot outlet 33; the first inlet 31 communicates with the blood outlet 11. The purifier filtrate inlet 21 of the blood purifier 2 is connected with the filtrate outlet 12 through the first flow control pressurizing pump 5, the waste liquid outlet 22 of the blood purifier 2 is connected with the waste liquid bag 6, and the purified liquid outlet 23 of the blood purifier 2 is connected with the second inlet 32 of the venous pot 3 through the second flow control pressurizing pump 7. The venous pot outlet 33 of the venous pot 3 is connected with one end of the second conduit 9, and the other end of the second conduit 9 is communicated with the vein of the human body.

With continued reference to fig. 2, the blood purifier 2 is internally provided with a waste liquid chamber 25 and a purification chamber 24, the top of the waste liquid chamber 25 is communicated with the purifier filtrate inlet 21, and the side of the waste liquid chamber 25 near the bottom is communicated with the waste liquid outlet 22; the purifying chamber 24 is communicated with the purifying liquid outlet 23, the waste liquid chamber 25 and the purifying chamber 24 are communicated with each other and are provided with a high-density filter membrane 26 in an isolated mode, the high-density filter membrane 26 can isolate medium-small molecular metabolic wastes and a certain amount of moisture in the waste liquid chamber 25, the moisture and electrolyte ions enter the purifying chamber 24, and the purified moisture and electrolyte ions enter the mixing cavity 34 through the purifying liquid outlet 23, the second flow control pressurizing pump 7 and the second inlet 32.

With continued reference to fig. 3, a filtration chamber 14 is provided in the hemofilter 1, a plurality of filtration channels 15 are provided in the filtration chamber 14, both ends of each filtration channel 15 are respectively communicated with the blood inlet 13 and the filtrate outlet 12, the filtration chamber 14 is communicated with the blood outlet 11, the channel wall of the filtration channel 15 is made of a high-flux filtration membrane 16, when blood flows through the filtering channel 15, about 20% of the water content in the blood, various ions and small molecule metabolites can enter the filtering cavity 14 and be discharged from the filtrate outlet 12, the concentrated blood formed by mixing the remaining 70% of the raw blood and 30% of the hemofiltered substances flows into the venous pot 3 through the blood outlet 11, and is mixed with the purified moisture and electrolyte ions entering from the second inlet 32 to form purified blood, which flows back to the venous blood vessel of the human body through the second conduit 9. The first flow control pressurizing pump 5 and the second flow control pressurizing pump are respectively internally provided with a flow sensor which can automatically sense the liquid flow and keep the liquid flow within a certain range, so that the flow of the backflow blood in the second conduit 9 is controlled within 100-300 ml/min.

In conclusion, the blood pump pumps the blood in the human body venous blood vessel, the blood filter, the blood purifier and related pipelines purify part of the blood of the human body, the filtered liquid with moisture and part of electrolyte ions is mixed with the concentrated human body original blood in the venous pot after impurities are discharged, and finally the blood is infused into the vein of the human body, so that the blood purification is realized; the purification method does not need to use dialysate or replacement fluid, is safe and reliable, and has small side effect; and simple structure and high integration level, and can be conveniently carried.

The foregoing descriptions of specific exemplary embodiments of the present invention have been presented for purposes of illustration and description. It is not intended to limit the invention to the precise form disclosed, and obviously many modifications and variations are possible in light of the above teaching. The exemplary embodiments were chosen and described in order to explain certain principles of the invention and its practical application to enable one skilled in the art to make and use various exemplary embodiments of the invention and various alternatives and modifications as are suited to the particular use contemplated. It is intended that the scope of the invention be defined by the claims and their equivalents.

Claims

1. A dialysate-free blood purifier, comprising:

a hemofilter (1) provided with a blood inlet (13), a blood outlet (11) and a filtrate outlet (12);

the blood purifier (2) is provided with a purifier filtrate inlet (21), the purifier filtrate inlet (21) is connected with the filtrate outlet (12), and the blood purifier (2) is also provided with a waste liquid outlet (22) and a purified liquid outlet (23);

the venous pot (3) is provided with a first inlet (31) and a second inlet (32), the first inlet (31) is connected with the blood outlet (11), the second inlet (32) is connected with the purified liquid outlet (23), and a venous pot outlet (33) is formed in the venous pot (3); and

a blood pump (4) provided with a blood pump inlet (41) and a blood pump outlet (42), the blood pump outlet (42) being connected to the blood inlet (13).

2. A dialysate-free blood purifier according to claim 1, wherein the filtrate outlet (12) is connected to the purifier filtrate inlet (21) by a first flow-controlled booster pump (5).

3. A dialysate-free blood purifier according to claim 1, wherein the waste liquid outlet (22) is connected to a waste liquid bag (6).

4. The dialysate-free blood purifier according to claim 1, wherein the purification liquid outlet (23) is connected to the second inlet (32) by a second flow-controlled booster pump (7).

5. The dialysate-free blood purifier according to claim 1, wherein the blood purifier (2) is internally provided with a waste liquid chamber (25) and a purification chamber (24), the waste liquid chamber (25) is respectively communicated with the purifier filtrate inlet (21) and the waste liquid outlet (22), the purification chamber (24) is communicated with the purification liquid outlet (23), and a high-density filter membrane (26) is provided between the waste liquid chamber (25) and the purification chamber (24).

6. A dialysate-free blood purifier according to claim 1, wherein a filtration chamber (14) is provided in the hemofilter (1), a filtration channel (15) is provided in the filtration chamber (14), both ends of the filtration channel (15) are respectively communicated with the blood inlet (13) and the filtrate outlet (11), and the filtration chamber (14) and the filtrate outlet (12) are communicated with each other.

7. The dialysate-free blood purifier according to claim 6, wherein the channel walls of the filtration channels (15) are high-flux filtration membranes (16).

8. A dialysate-free blood purifier according to claim 1, wherein the venous pot (3) has a mixing chamber (34) therein communicating with the first inlet (31), the second inlet (32) and the venous pot outlet (33), respectively.

9. The dialysate-free blood purifier according to claim 1, wherein an amount of liquid discharged from the filtrate outlet (12) after filtration by the hemofilter (1) is 30% of an amount of liquid introduced into the blood inlet (13).