CN213284806U

CN213284806U - Blood purification composite set

Info

Publication number: CN213284806U
Application number: CN202021512284.XU
Authority: CN
Inventors: 高光勇; 李绍林; 赖明忠; 朱平
Original assignee: Sws Hemodialysis Care Co ltd
Current assignee: Sws Hemodialysis Care Co ltd
Priority date: 2020-07-28
Filing date: 2020-07-28
Publication date: 2021-05-28
Anticipated expiration: 2030-07-28

Abstract

The utility model provides a blood purification composite set belongs to medical instrument technical field. It has solved the problem that current blood purifies composite set can't clear away in the blood and albumin binding toxin. It includes the blood pipeline, be equipped with blood pump and cerini dialyser cerini on the blood pipeline, be equipped with first dialysis tubing in the cerini dialyser cerini, a plurality of first wall holes have on the first dialysis tubing, still be equipped with the plasma separator on the blood pipeline, be equipped with the second dialysis tubing in the plasma separator, a plurality of second wall holes have on the second dialysis tubing, the aperture in second wall hole is greater than the aperture in first wall hole, be connected with the plasma pipeline on the plasma separator, be equipped with the shunt pump on the plasma pipeline and be used for adsorbing the adsorber that combines toxin with albumin. The utility model discloses can clear away albumin binding toxin, clear away effectually.

Description

Blood purification composite set

Technical Field

The utility model belongs to the technical field of medical instrument, a blood purifies composite set is related to, especially a blood purifies composite set for driving albumin combines toxin.

Background

Crrt (continuous renal replacement therapy) is a general term for all treatment modes of continuously and slowly removing water and solutes, and is a blood purification technology supporting the functions of human organs. With the development of blood purification technology, CRRT has been gradually extended from the treatment of acute and chronic renal insufficiency to the rescue and treatment of patients with acute and severe symptoms such as Multiple Organ Dysfunction Syndrome (MODS), Systemic Inflammatory Response Syndrome (SIRS), fulminant hepatic failure, severe hemorrhagic necrotizing pancreatitis, and the like.

For example, chinese patent discloses a continuous blood purification apparatus [ grant No. CN209154671U ] including a blood circuit, a fluid replacement circuit, and a waste fluid circuit. The blood loop comprises a blood pipeline respectively connected with an artery and a vein of a human body, a dialyzer and a blood pump are arranged on the blood pipeline, and the blood pump provides power for the blood flowing in the blood pipeline; the fluid infusion loop comprises a fluid infusion pipeline connected with a venous pot on the blood pipeline, and further comprises a fluid infusion bag and a fluid infusion pump which respectively correspond to the fluid infusion pipeline, and the fluid infusion pump provides power for replacement fluid in the fluid infusion bag to flow into the venous pot; the waste liquid return circuit includes the waste liquid pipeline of being connected with cerini dialyser cerini waste liquid one side, and the waste liquid return circuit still includes waste liquid bag and waste liquid pump, and the waste liquid pump provides power for the waste liquid flow direction waste liquid bag.

The continuous blood purification device removes small molecular toxins such as: urea Nitrogen (BUN), creatinine (Scr), Uric Acid (UA) and the like, and utilizes the principle of removing solute by convection to remove excessive water and small molecular toxins in polypeptides in blood and regulate the acid-base balance and electrolyte balance of human blood. However, albumin-bound toxins (e.g., fatty acids, bilirubin, various hormones, etc.) in blood are insoluble in water, and the pore size of the dialyzer membrane is small, so that albumin-bound toxins in blood cannot be removed.

SUMMERY OF THE UTILITY MODEL

The utility model aims at solving the problems in the prior art and providing a blood purification combined device capable of removing albumin-bound toxin.

The purpose of the utility model can be realized by the following technical proposal:

a blood purification combined device comprises a blood pipeline, wherein a blood pump and a dialyzer are arranged on the blood pipeline, a first dialysis pipe used for dividing the inner cavity of the dialyzer into a first blood circulation space and a replacement liquid circulation space is arranged in the dialyzer, a plurality of first wall holes are formed in the first dialysis pipe, the blood pipeline is communicated with the first blood circulation space, the replacement liquid circulation space is connected with a liquid supplementing bag through a liquid supplementing pipeline and is connected with a waste liquid bag through a waste liquid pipeline, a liquid supplementing pump is arranged on the liquid supplementing pipeline, a waste liquid pump is arranged on the waste liquid pipeline, a plasma separator is further arranged on the blood pipeline, a second dialysis pipe used for dividing the inner cavity of the plasma separator into a second blood circulation space and a plasma circulation space is arranged in the plasma separator, a plurality of second wall holes are formed in the second dialysis pipe, the aperture of the second wall hole is larger than that of the first wall hole, the blood pipeline is communicated with the second blood circulation space, the plasma separator is connected with a plasma pipeline, two ends of the plasma pipeline are respectively communicated with the plasma circulation space, and the plasma pipeline is provided with a shunt pump and an adsorber for adsorbing the albumin-bound toxin.

The input end of the blood pipeline is connected with the artery of the human body, the output end of the blood pipeline is connected with the vein of the human body, and the blood pump, the plasma separator and the dialyzer are sequentially arranged along the flowing direction of the blood in the blood pipeline. The liquid supplementing bag is filled with fresh replacement liquid, and the formula of the fresh replacement liquid is consistent with the physiological concentration of a human body and is basically consistent with the plasma electrolyte under the normal physiological condition of the human body. When hemodialysis is needed, solute is removed through the effect of dispersion, and the maximum molecular cut-off of the dialyzer is 5000D; when hemofiltration is required, solutes are removed by means of convection, and the maximum molecular cut-off of the dialyzer is 30K-50 KD. The plasma separator is similar to the structure of the dialyzer, and the pore diameter of the second wall pores is 0.2-0.6 μm.

The blood purification combination device can be divided into blood extracorporeal circulation, plasma extracorporeal circulation and dialysate circulation according to the type of liquid flowing in the pipeline.

Blood extracorporeal circulation: the blood pump provides power, blood is extracted from a human body to the blood pipeline, the blood is sequentially sent to two blood purification places of the plasma separator and the dialyzer, and the purified blood is then returned to the human body.

Plasma extracorporeal circulation: the shunt pump provides power to separate the blood plasma containing the albumin-bound toxin from the blood cells, then the blood plasma is sent to the adsorber, the albumin-bound toxin is transferred into the adsorber, and the purified albumin is sent back to the blood plasma circulation space of the blood plasma separator; the albumin is combined with the toxin in the blood again and is sent to the adsorber again, and the circulation is repeated in such a way, and finally the toxin combined with the albumin in the blood is transferred to the adsorber, thereby achieving the purpose of treatment.

And (3) dialysate circulation: the fluid infusion pump provides power, continuously introduces fresh replacement fluid into a replacement fluid circulation space of the dialyzer, realizes acid-base balance and electrolyte balance through solute dispersion principle and blood ion exchange, and removes small and medium molecular toxins such as urea nitrogen (BUN), creatinine (Scr), Uric Acid (UA) and the like dissolved in water in blood; the waste liquid pump (UFP) provides power to pump the liquid containing toxin in the replacement liquid circulation space and the redundant water in the blood to the waste liquid bag, thus continuously realizing the blood purification treatment.

In the blood purification assembly, the two adsorbers are: the plasma treatment device comprises an anion adsorber and a cation/neutral adsorber which are connected in series on a plasma pipeline.

The plasma enters an anionic adsorber where the albumin-bound anionic toxins are transferred to the anionic adsorber and the plasma enters a cationic or neutral adsorber where the albumin-bound cationic or neutral ionic toxins are transferred to the cationic or neutral adsorber.

In the blood purification assembly device, the plasma separator is cylindrical, the second dialysis tube and the plasma separator are coaxially arranged, the second blood circulation space is located in the second dialysis tube, the plasma circulation space is located between the second dialysis tube and the plasma separator, and the flow direction of liquid in the second blood circulation space is opposite to the flow direction of liquid in the plasma circulation space.

In the blood purification assembly device, the dialyzer is cylindrical, the first dialysis tube and the dialyzer are coaxially arranged, the first blood circulation space is located in the first dialysis tube, the substitution fluid circulation space is located between the first dialysis tube and the dialyzer, and the flow direction of the fluid in the first blood circulation space is opposite to the flow direction of the fluid in the substitution fluid circulation space.

In the blood purification assembly, the first dialysis tube is a fiber tube, and the second dialysis tube is a fiber tube.

In the blood purification assembly, the fluid infusion line is provided with a heater for heating the fluid in the fluid infusion line.

In the blood purification assembly, the blood line is provided with a heparin injector between the blood pump and the plasma separator.

In the blood purification combination device, the fluid infusion bag is positioned on the fluid infusion scale, and the waste fluid bag is positioned on the waste fluid scale.

In the blood purification combination device, the blood pipeline is provided with an arterial pressure sensor, a pre-filter pressure sensor and a venous pressure sensor, the arterial pressure sensor is positioned at the upstream of the blood pump, the venous pressure sensor is positioned at the downstream of the dialyzer, and the pre-filter pressure sensor is positioned at the upstream of the plasma separator.

The arterial pressure sensor is positioned between the human body and the blood pump and used for sensing the arterial pressure of the human body; the venous pressure sensor is positioned between the human body and the dialyzer and used for sensing the venous pressure of the human body; the pre-filter pressure sensor is used for sensing the pressure of blood passing through the blood pump.

In the blood purification combination device, the plasma pipeline is provided with a first-stage membrane external pressure sensor positioned between the anion adsorber and the cation/neutral adsorber, and the waste liquid pipeline is provided with a second-stage membrane external pressure sensor positioned between the dialyzer and the waste liquid pump.

In the blood purification combination device, the blood pipeline is provided with a blood bubble air monitoring sensor.

Compared with the prior art, the blood purification combination device has the following advantages: the serum separator, the anion adsorber and the cation/neutral adsorber can remove toxins such as fatty acid, bilirubin, various hormones and the like bound to albumin, and the removal effect is good.

Drawings

Fig. 1 is a schematic diagram of a preferred embodiment of the present invention.

Figure 2 is a cross-sectional view of the dialyzer provided by the present invention.

Fig. 3 is a cross-sectional view of the plasma separator provided by the present invention.

In the figure, 1, the blood line; 2. a dialyzer; 21. a first blood circulation space; 22. a replacement fluid circulation space; 3. a first dialysis tube; 4. a liquid supplementing pipeline; 5. a fluid infusion bag; 6. a waste liquid line; 7. a waste liquid bag; 8. a plasma separator; 81. a second blood circulation space; 82. a plasma circulation space; 9. a second dialysis tube; 10. a plasma line; 11. an anion adsorber; 12. a cation/neutral adsorber; 13. a heater; 14. a heparin infuser; 15. a blood bubble air monitoring sensor; BP, blood pump; LP1, fluid replacement pump; UFP, waste liquid pump; LP2, splitter pump; LB, liquid supplement scale; UFB, waste liquid balance; PA, arterial pressure sensor; PBE, pre-filter pressure sensor; PV, venous pressure sensors; PM1, first-stage membrane external pressure sensor; PM2, secondary external membrane pressure sensor.

Detailed Description

The following are specific embodiments of the present invention and the accompanying drawings are used to further describe the technical solution of the present invention, but the present invention is not limited to these embodiments.

The blood purification combination device shown in fig. 1 comprises a blood pipeline 1 with one end connected with an artery of a human body, the other end of the blood pipeline 1 is connected with a vein of the human body, and a blood pump BP, a plasma separator 8 and a dialyzer 2 are sequentially arranged on the blood pipeline 1 along the flow direction of blood in the blood pipeline 1.

The dialyzer 2 is cylindrical, a first dialysis tube 3 is coaxially disposed in the dialyzer 2, a first blood circulation space 21 communicating with the blood line 1 is provided inside the first dialysis tube 3, and a replacement fluid circulation space 22 is formed between the outer wall of the dialyzer 2 and the first dialysis tube 3. The flow direction of the fluid in the first blood circulation space 21 is opposite to the flow direction of the fluid in the replacement fluid circulation space 22. Wherein, the first dialysis tube 3 is a fiber tube, which has several first wall holes. A liquid supplementing pipeline 4 communicated with the replacement liquid circulating space 22 is arranged at the liquid outlet end of the dialyzer 2, one end of the liquid supplementing pipeline 4 far away from the dialyzer 2 is connected with a liquid supplementing bag 5, the liquid supplementing bag 5 is arranged on a liquid supplementing scale LB, and a liquid supplementing pump LP1 and a heater 13 are arranged on the liquid supplementing pipeline 4. Be equipped with the waste liquid pipeline 6 with replacement liquid circulation space 22 intercommunication at the inlet end department of cerini dialyser cerini 2, the one end that cerini dialyser cerini 2 was kept away from to this waste liquid pipeline 6 is connected with waste liquid bag 7, and waste liquid bag 7 is equipped with waste liquid pump UFP on waste liquid balance UFB on waste liquid pipeline 6. As shown in fig. 1, the fluid replacement line 4 is provided with a heater 13 for heating the fluid in the fluid replacement line 4.

The liquid supplementing bag 5 is filled with fresh replacement liquid, and the formula of the fresh replacement liquid is consistent with the physiological concentration of a human body and is basically consistent with the plasma electrolyte under the normal physiological condition of the human body. When hemodialysis is required, solute is removed through the effect of dispersion, and the maximum molecular cut-off of the dialyzer 2 is 5000D; when hemofiltration is required, solutes are removed by means of convection, at which time the maximum molecular cut-off of dialyzer 2 is 30K-50 KD.

The plasma separator 8 is cylindrical and has a structure similar to that of the dialyzer 2, a second dialysis tube 9 is coaxially provided in the plasma separator 8, a second blood circulation space 81 communicating with the blood line 1 is provided inside the second dialysis tube 9, and a plasma circulation space 82 is formed between the outer wall of the plasma separator 8 and the second dialyzer 2. The flow of liquid in the second blood circulation space 81 is opposite to the flow of liquid in the plasma circulation space 82. Wherein the second dialysis tube 9 is a fiber tube, and has several second wall holes with a diameter larger than that of the first wall holes and a diameter of 0.2-0.6 μm. The plasma separator 8 is connected with a plasma pipeline 10, the liquid inlet end of the plasma pipeline 10 is positioned at the liquid inlet end of the plasma separator 8, the liquid outlet end of the plasma pipeline 10 is positioned at the liquid outlet end of the plasma separator 8, and the plasma pipeline 10 is sequentially provided with a flow splitting pump LP2, an anion adsorber 11 and a cation/neutral adsorber 12 along the flow direction of plasma.

The split-flow pump LP2, the anion adsorber 11 and the cation/neutral adsorber 12 are arranged in this order in the transport direction of the plasma line 10, i.e. the split-flow pump LP2 is located upstream of the anion adsorber 11 and the anion adsorber 11 is located upstream of the cation/neutral adsorber 12. The split flow pump LP2 operates to sequentially feed plasma into the anion adsorber 11 where the albumin-bound anionic toxins are transferred into the anion adsorber 11 and then into the cation or neutral adsorber where the albumin-bound cationic or neutral toxins are transferred into the cation or neutral adsorber.

As shown in fig. 1, a heparin injector 14 may optionally be provided on the blood line 1 between the blood pump BP and the plasma separator 8.

Blood extracorporeal circulation: the blood pump BP provides power, blood is extracted from a human body to the blood pipeline 1, the blood is sequentially sent to two blood purification places of the plasma separator 8 and the dialyzer 2, and the purified blood is then returned to the human body.

Plasma extracorporeal circulation: the split-flow pump LP2 is powered to separate plasma containing albumin-bound toxins from blood cells, and then to send the plasma to the adsorber, where the albumin-bound toxins are transferred to the adsorber, and the purified albumin is sent back to the plasma circulation space 82 of the plasma separator 8; the albumin is combined with the toxin in the blood again and is sent to the adsorber again, and the circulation is repeated in such a way, and finally the toxin combined with the albumin in the blood is transferred to the adsorber, thereby achieving the purpose of treatment.

And (3) dialysate circulation: the liquid supplementing pump LP1 provides power, continuously introduces the heated fresh replacement liquid into the replacement liquid circulating space 22 of the dialyzer 2, realizes acid-base balance and electrolyte balance through solute dispersion principle and blood ion exchange, and removes small and medium molecular toxins such as urea nitrogen (BUN), creatinine (Scr), Uric Acid (UA) and the like dissolved in water in blood; the waste liquid pump UFP provides a power to pump the toxin-containing liquid and the excess water in the blood in the replacement liquid circulation space 22 to the waste liquid bag 7, thus continuously performing the blood purification treatment.

The blood purification combined device also comprises a safety monitoring system which consists of a waste liquid scale UFB, a liquid supplementing scale LB, an arterial pressure sensor PA, a pre-filtration pressure sensor PBE, a venous pressure sensor PV, a primary external membrane pressure sensor PM1, a secondary external membrane pressure sensor PM2 and a blood bubble air monitoring sensor 15.

Wherein the arterial pressure sensor PA is located upstream of the blood pump BP, the venous pressure sensor PV is located downstream of the dialyzer 2, and the pre-filter pressure sensor PBE is located upstream of the plasma separator 8. Namely, the arterial pressure sensor PA is positioned between the human body and the blood pump BP and is used for sensing the arterial pressure of the human body; the venous pressure sensor PV is positioned between the human body and the dialyzer 2 and is used for sensing the venous pressure of the human body; the pre-filter pressure sensor PBE is used to sense the pressure of the blood after passing through the blood pump BP. The first stage external membrane pressure sensor PM1 is located between the anion adsorber 11 and the cation/neutral adsorber 12, and the second stage external membrane pressure sensor PM2 is located between the dialyzer 2 and the waste liquid pump UFP. A blood bubble air monitoring sensor 15 is located on the bloodline 1.

The specific embodiments described herein are merely illustrative of the spirit of the invention. Various modifications, additions and substitutions for the specific embodiments described herein may be made by those skilled in the art without departing from the spirit of the invention or exceeding the scope of the invention as defined in the accompanying claims.

Claims

1. The utility model provides a blood purification composite set, includes blood pipeline (1), blood pipeline (1) on be equipped with Blood Pump (BP) and cerini dialyser cerini (2), cerini dialyser cerini (2) in be equipped with and be used for dividing into first blood circulation space (21) and first dialysis tubing (3) of replacement liquid circulation space (22) with the inner chamber of cerini dialyser cerini (2), first dialysis tubing (3) on have a plurality of first wall holes, blood pipeline (1) and first blood circulation space (21) intercommunication, replacement liquid circulation space (22) be connected with fluid infusion bag (5) and be connected with waste liquid bag (7) through waste liquid pipeline (6) through fluid infusion pipeline (4), fluid infusion pipeline (4) on be equipped with fluid infusion pump (LP1), waste liquid pipeline (6) on be equipped with waste liquid pump (UFP), its characterized in that, blood pipeline (1) on still be equipped with blood plasma separator (8), the plasma separator (8) in be equipped with and be used for dividing into second blood circulation space (81) and plasma circulation space (82)'s second dialysis pipe (9) with the inner chamber of plasma separator (8), second dialysis pipe (9) on have a plurality of second wall holes, the aperture of second wall hole is greater than the aperture of first wall hole, blood pipeline (1) and second blood circulation space (81) intercommunication, plasma separator (8) on be connected with plasma pipeline (10) that its both ends communicate with plasma circulation space (82) respectively, plasma pipeline (10) on be equipped with shunt pump (LP2) and be used for adsorbing the adsorber with albumin binding toxin.

2. The blood purification assembly of claim 1, wherein the two adsorbers are: the plasma tube is characterized by comprising an anion adsorber (11) and a cation/neutral adsorber (12), wherein the anion adsorber (11) and the cation/neutral adsorber (12) are connected in series on the plasma tube (10).

3. A combined blood purification device according to claim 1 or 2, wherein the plasma separator (8) is cylindrical, the second dialysis tube (9) is arranged coaxially with the plasma separator (8), the second blood circulation space (81) is located inside the second dialysis tube (9), the plasma circulation space (82) is located between the second dialysis tube (9) and the plasma separator (8), and the flow direction of the liquid in the second blood circulation space (81) is opposite to the flow direction of the liquid in the plasma circulation space (82).

4. A combined blood purification device according to claim 3, wherein the dialyzer (2) is in the form of a tube, the first dialysis tubing (3) is coaxially arranged with the dialyzer (2), the first blood circulation space (21) is located within the first dialysis tubing (3), the substitution fluid circulation space (22) is located between the first dialysis tubing (3) and the dialyzer (2), and the flow direction of the fluid in the first blood circulation space (21) is opposite to the flow direction of the fluid in the substitution fluid circulation space (22).

5. A combined blood purification device according to claim 1, wherein the first dialysis tubing (3) is a fiber tubing and the second dialysis tubing (9) is a fiber tubing.

6. A blood purification assembly as claimed in claim 1, wherein the fluid replacement line (4) is provided with a heater (13) for heating the fluid in the fluid replacement line (4).

7. A blood purification assembly as claimed in claim 1, wherein the blood line (1) is provided with a heparin injector (14) located between the Blood Pump (BP) and the plasma separator (8).

8. A blood purification assembly as claimed in claim 1, wherein the fluid replacement bag (5) is located on a fluid replacement scale (LB) and the waste fluid bag (7) is located on a waste fluid scale (UFB).