CN117797352A - Blood purification method convenient for improving purification efficiency - Google Patents
Blood purification method convenient for improving purification efficiency Download PDFInfo
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- CN117797352A CN117797352A CN202410019994.5A CN202410019994A CN117797352A CN 117797352 A CN117797352 A CN 117797352A CN 202410019994 A CN202410019994 A CN 202410019994A CN 117797352 A CN117797352 A CN 117797352A
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- pump
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- 239000008280 blood Substances 0.000 title claims abstract description 145
- 210000004369 blood Anatomy 0.000 title claims abstract description 145
- 238000000746 purification Methods 0.000 title claims abstract description 46
- 238000000034 method Methods 0.000 title claims abstract description 18
- 239000002699 waste material Substances 0.000 claims abstract description 34
- 230000010412 perfusion Effects 0.000 claims abstract description 25
- 238000001179 sorption measurement Methods 0.000 claims abstract description 24
- 150000002500 ions Chemical class 0.000 claims abstract description 18
- 230000002503 metabolic effect Effects 0.000 claims abstract description 15
- 238000001631 haemodialysis Methods 0.000 claims abstract description 8
- 230000000322 hemodialysis Effects 0.000 claims abstract description 8
- 229940079593 drug Drugs 0.000 claims abstract description 6
- 239000003814 drug Substances 0.000 claims abstract description 6
- 231100000614 poison Toxicity 0.000 claims abstract description 6
- 239000002574 poison Substances 0.000 claims abstract description 5
- 238000000926 separation method Methods 0.000 claims abstract description 5
- 231100000331 toxic Toxicity 0.000 claims abstract description 4
- 230000002588 toxic effect Effects 0.000 claims abstract description 4
- 239000007788 liquid Substances 0.000 claims description 58
- 239000012528 membrane Substances 0.000 claims description 56
- 210000003462 vein Anatomy 0.000 claims description 20
- 210000001367 artery Anatomy 0.000 claims description 16
- 239000003146 anticoagulant agent Substances 0.000 claims description 15
- 229940127219 anticoagulant drug Drugs 0.000 claims description 15
- 238000006467 substitution reaction Methods 0.000 claims description 12
- 239000000126 substance Substances 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 239000003792 electrolyte Substances 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 239000011347 resin Substances 0.000 claims description 6
- 229920005989 resin Polymers 0.000 claims description 6
- 238000002615 hemofiltration Methods 0.000 claims description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 4
- 230000008081 blood perfusion Effects 0.000 claims description 4
- 230000001951 hemoperfusion Effects 0.000 claims description 4
- 238000000108 ultra-filtration Methods 0.000 claims description 3
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 238000002955 isolation Methods 0.000 claims description 2
- 238000000502 dialysis Methods 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 5
- 238000000354 decomposition reaction Methods 0.000 abstract description 2
- 229920002521 macromolecule Polymers 0.000 description 4
- 238000007599 discharging Methods 0.000 description 3
- 230000001154 acute effect Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 208000009304 Acute Kidney Injury Diseases 0.000 description 1
- 208000033626 Renal failure acute Diseases 0.000 description 1
- 206010062237 Renal impairment Diseases 0.000 description 1
- 201000011040 acute kidney failure Diseases 0.000 description 1
- 208000012998 acute renal failure Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 208000020832 chronic kidney disease Diseases 0.000 description 1
- 208000022831 chronic renal failure syndrome Diseases 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 238000002616 plasmapheresis Methods 0.000 description 1
- 231100000857 poor renal function Toxicity 0.000 description 1
- 238000012959 renal replacement therapy Methods 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
Abstract
The invention discloses a blood purification method convenient for improving purification efficiency, which relates to the technical field of blood purification and comprises the following operation steps: s1: hemodialysis, which draws the patient's blood out of the body and then through a dialyzer to remove toxic components from the blood. According to the invention, the adsorption layer is arranged in the perfusion device, so that blood is contacted with the adsorption layer in the perfusion device, certain metabolic products and exogenous drugs or poisons in the body are removed in an adsorption mode, and the ion filter tube is connected to one end of the dialysis device, so that separation and decomposition of metabolic waste ions are facilitated, and the dialysis purification efficiency and effect are improved.
Description
Technical Field
The invention relates to the technical field of blood purification, in particular to a blood purification method convenient for improving purification efficiency.
Background
CRRT (continuous renal replacement therapy), also known as bedside hemofiltration, is defined as a long-term, continuous extracorporeal blood purification therapy that replaces impaired renal function, by introducing the patient's blood into the body and passing it through a purification device that removes some pathogenic substances from the blood for the purpose of treating the disease, and includes mainly hemodialysis, hemofiltration, hemodiafiltration, hemoperfusion, plasmapheresis, immunoadsorption, peritoneal dialysis, etc.
At present, the blood purification therapy is not only used for treating acute and chronic renal failure patients, but also widely applied to rescue treatment of acute and critical patients, and when the patients are subjected to blood purification, the purification efficiency is lower due to the imperfect internal filter system, so that the filtration rate of metabolic wastes is difficult to improve.
Disclosure of Invention
The invention aims to provide a blood purification method which is convenient for improving the purification efficiency so as to solve the technical problems in the background technology.
In order to achieve the above purpose, the present invention provides the following technical solutions: a blood purification method for facilitating improvement of purification efficiency, comprising the steps of:
s1: hemodialysis, namely leading out the blood of a patient from the body, and then removing toxic components in the blood through a dialyzer;
s2: blood perfusion, namely leading out the blood of a patient from the body, and finishing adsorption through an adsorption layer in a perfusion device and returning the blood to the body of the patient;
s3: ultrafiltration of blood, namely filtering out water and solute in the blood in a convection way, so as to achieve the purpose of removing the water and the solute;
s4: hemofiltration, in which venous blood is led out of a dialyzer for separation, harmful substances are filtered out and isolated, and then the filtered and isolated blood is re-input into a patient.
Preferably, in the step S1, the dialyzer is placed on the filter fixing clamp, then the external dialysate bag is hung on the liquid support, then the first blood pipeline is connected out from the artery of the human body, the blood pump is wound, one membrane joint of the dialyzer is connected, the anticoagulant pump is connected into the first blood pipeline, and the second blood pipeline is connected into the vein of the human body from the other membrane joint of the dialyzer.
Preferably, in the step S1, the dialysate line is connected to an external dialysate bag, and then connected to an external joint of the dialyzer through a dialysate/substitution liquid pump and a dialysate/substitution liquid flow rate detector.
Preferably, in the step S1, harmful and redundant metabolic wastes and excessive electrolytes in blood are removed from the body by utilizing a semipermeable membrane principle, so that the purpose of purifying the blood is achieved, and the purposes of correcting water electrolytes and acid-base balance are achieved.
Preferably, in the step S2, the perfusion device is placed on the filter fixing clamp, then the first blood pipeline is connected out of the artery of the human body, the blood is connected to a joint of the perfusion device by a blood pump, so that the blood is contacted with an adsorption layer inside the perfusion device, the perfusion device can be used for removing certain metabolites and exogenous medicines or poisons in the body, the anticoagulant pump is connected to the first blood pipeline, and the second blood pipeline is connected to the vein of the human body from the other joint of the perfusion device.
Preferably, the adsorption layer in S2 may be one or two of a resin and an activated carbon adsorption layer in the HA resin hemoperfusion apparatus.
Preferably, in the step S3, the dialyzer is placed on the filter fixing clamp, then the first blood pipeline is connected out from the artery of the human body, the blood pump is wound, one membrane joint of the dialyzer is connected, the anticoagulant pump is connected into the first blood pipeline, the second blood pipeline is connected into the vein of the human body from the other membrane joint of the dialyzer, the ion filter pipe is connected into the other membrane joint of the dialyzer, and the blood pump can be used for separating and discharging metabolic waste ions, and the second blood pipeline is connected into the vein of the human body from the other membrane joint of the ion filter pipe.
Preferably, in the step S4, the dialyzer is placed on the filter fixing clamp, then the external replacement liquid bag is hung on the liquid support, then the first blood pipeline is connected from the artery of the human body, the blood pump is wound, the first membrane connector of the dialyzer is connected, the semipermeable membrane structure and the macromolecule isolating layer inside the dialyzer can be used for filtering and isolating harmful substances, the anticoagulant pump is connected to the first blood pipeline, and the second blood pipeline is connected from the second membrane connector of the dialyzer to the vein of the human body.
Preferably, in the step S4, the substitution liquid line is connected to the external substitution liquid bag, and the first membrane connector of the dialyzer is directly connected to the substitution liquid pump or the dialysate/substitution liquid flow detector, or the first membrane connector of the filter is connected to the first blood line.
Preferably, in S1, the waste liquid pipeline is connected out from another external joint of the dialyzer, and is connected into an external waste liquid container through the blood leakage detector, the waste liquid pump and the waste liquid flow detector, and in S2 and S4, the waste liquid pipeline is connected out from one external joint of the dialyzer, and is connected into the external waste liquid container through the blood leakage detector, the waste liquid pump and the waste liquid flow detector.
Compared with the prior art, the invention has the beneficial effects that:
according to the invention, the adsorption layer is arranged in the perfusion device, so that blood is contacted with the adsorption layer in the perfusion device, certain metabolic products and exogenous drugs or poisons in the body are removed in an adsorption mode, and the ion filter tube is connected to one end of the dialysis device, so that separation and decomposition of metabolic waste ions are facilitated, and the dialysis purification efficiency and effect are improved.
Drawings
FIG. 1 is a schematic flow chart of the blood purification method of the present invention.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Referring to fig. 1, the present invention provides a technical solution: a blood purification method for facilitating improvement of purification efficiency, comprising the steps of:
s1: hemodialysis, namely leading out the blood of a patient from the body, and then removing toxic components in the blood through a dialyzer;
s2: blood perfusion, namely leading out the blood of a patient from the body, and finishing adsorption through an adsorption layer in a perfusion device and returning the blood to the body of the patient;
s3: ultrafiltration of blood, namely filtering out water and solute in the blood in a convection way, so as to achieve the purpose of removing the water and the solute;
s4: hemofiltration, in which venous blood is led out of a dialyzer for separation, harmful substances are filtered out and isolated, and then the filtered and isolated blood is re-input into a patient.
In the step S1, the dialyzer is firstly arranged on the filter fixing clamp, then an external dialysate bag is hung on the liquid support, then the first blood pipeline is connected out from the artery of the human body, the blood pump is wound, one membrane joint of the dialyzer is connected, the anticoagulant pump is connected into the first blood pipeline, and the second blood pipeline is connected into the vein of the human body from the other membrane joint of the dialyzer.
In the step S1, a dialysate pipeline is connected out from an external dialysate bag, and is connected into an external membrane joint of the dialyzer after passing through a dialysate/substitution liquid pump and a dialysate/substitution liquid flow detector.
In the S1, the harmful and redundant metabolic wastes and excessive electrolytes in the blood are removed from the body by diffusion by utilizing the semi-permeable membrane principle, so that the purpose of purifying the blood is achieved, and the purposes of correcting water electrolyte and acid-base balance are achieved.
In the step S2, the perfusion device is firstly arranged on the filter fixing clamp, then the first blood pipeline is connected out of an artery of a human body, a blood pump is wound, the perfusion device is connected into one joint of the perfusion device, so that blood is contacted with an adsorption layer in the perfusion device, certain metabolic products and exogenous medicines or poisons in the body are removed in an adsorption mode, the anticoagulant pump is connected into the first blood pipeline, and the second blood pipeline is connected into a vein of the human body from the other joint of the perfusion device.
The adsorption layer in the S2 can be one or two of resin and active carbon adsorption layer in the HA resin hemoperfusion apparatus.
In the step S3, the dialyzer is arranged on the filter fixing clamp, then the first blood pipeline is connected out from the artery of the human body, the blood pump is wound, one membrane joint of the dialyzer is connected, the anticoagulant pump is connected into the first blood pipeline, the second blood pipeline is connected into the vein of the human body from the other membrane joint of the dialyzer, the ion filter pipe is connected into the other membrane joint of the dialyzer, and the ion filter pipe is used for separating and discharging metabolic waste ions so as to improve the dialysis purification efficiency and effect, and the second blood pipeline is connected into the vein of the human body from the other membrane joint of the ion filter pipe.
In S4, the dialyzer is arranged on the filter fixing clamp, then the external replacement liquid bag is hung on the liquid support, then the first blood pipeline is connected out from the human artery, the blood pump is wound, the first membrane joint of the dialyzer is connected, harmful substances are filtered and isolated through the semipermeable membrane structure and the macromolecule isolating layer in the dialyzer, the loss of useful macromolecule substances in blood is prevented, the rehabilitation effect is improved, the anticoagulant pump is connected into the first blood pipeline, and the second blood pipeline is connected into the human vein from the second membrane joint of the dialyzer.
And S4, connecting the replacement liquid pipeline out of the external replacement liquid bag, directly connecting a first membrane joint of the dialyzer after passing through a dialysate/replacement liquid pump and a dialysate/replacement liquid flow detector or connecting the first membrane joint of the filter after connecting the first blood pipeline.
In the S1, a waste liquid pipeline is connected out from the other external membrane connector of the dialyzer and is connected into an external waste liquid container through a blood leakage detector, a waste liquid pump and a waste liquid flow detector, and in the S2 and the S4, the waste liquid pipeline is connected out from the one external membrane connector of the dialyzer and is connected into the external waste liquid container through the blood leakage detector, the waste liquid pump and the waste liquid flow detector.
To sum up: when hemodialysis is carried out, the dialyzer is firstly placed on the filter fixing clamp, then the external dialysate bag is hung on the liquid support, then the first blood pipeline is connected out from the human artery, the blood pump is wound, one membrane joint of the dialyzer is connected, the anticoagulant pump is connected into the first blood pipeline, the second blood pipeline is connected into the human vein from the other membrane joint of the dialyzer, meanwhile, the dialysate pipeline is connected out from the external dialysate bag, the dialysate/substitution liquid pump and the dialysate/substitution liquid flow detector are connected into one outer membrane joint of the dialyzer, when the blood perfusion is carried out, the first blood pipeline is connected out from the human artery, the blood pump is wound, one joint of the perfusion device is connected, the blood is contacted with an adsorption layer in the perfusion device, certain metabolic products and exogenous medicines or toxic substances in the human body are removed in an adsorption mode, and the anticoagulant pump is connected into the first blood pipeline, the second blood pipeline is connected with the vein of the human body from the other joint of the perfusion device, when hemodialysis is carried out, the first blood pipeline is connected with the artery of the human body, the blood pump is wound, one membrane joint of the dialyzer is connected with the first blood pipeline, the second blood pipeline is connected with the vein of the human body from the other membrane joint of the dialyzer, the ion filter pipe is connected with the other membrane joint of the dialyzer, the ion filter pipe is used for separating and discharging the metabolic waste ions so as to improve the dialysis purification efficiency and effect, the second blood pipeline is connected with the vein of the human body from the other membrane joint of the ion filter pipe, when hemodialysis is carried out, the first blood pipeline is connected with the artery of the human body, the blood pump is wound, the first membrane joint of the dialyzer is connected, and harmful substances are filtered and isolated through the semipermeable membrane structure and the macromolecule isolation layer inside the first membrane joint of the dialyzer, the anti-coagulant pump is connected to the first blood pipeline, the second blood pipeline is connected to the vein of human body from the second membrane joint of the dialyzer, and meanwhile, the replacement liquid pipeline is connected out from the external replacement liquid bag, and is directly connected to the first membrane joint of the dialyzer or connected to the first membrane joint of the filter after passing through the dialysate/replacement liquid pump and the dialysate/replacement liquid flow detector, or is connected to the first membrane joint of the filter after being connected to the first blood pipeline, which is not described in detail in the description belongs to the prior art known to the person skilled in the art.
Although the present invention has been described with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments described, or equivalents may be substituted for elements thereof, and any modifications, equivalents, improvements and changes may be made without departing from the spirit and principles of the present invention.
Claims (10)
1. A blood purification method for facilitating improvement of purification efficiency, comprising the steps of:
s1: hemodialysis, namely leading out the blood of a patient from the body, and then removing toxic components in the blood through a dialyzer;
s2: blood perfusion, namely leading out the blood of a patient from the body, and finishing adsorption through an adsorption layer in a perfusion device and returning the blood to the body of the patient;
s3: ultrafiltration of blood, namely filtering out water and solute in the blood in a convection way, so as to achieve the purpose of removing the water and the solute;
s4: hemofiltration, in which venous blood is led out of a dialyzer for separation, harmful substances are filtered out and isolated, and then the filtered and isolated blood is re-input into a patient.
2. A blood purification method facilitating improvement of purification efficiency according to claim 1, wherein: in the step S1, the dialyzer is firstly arranged on the filter fixing clamp, then an external dialysate bag is hung on the liquid support, then the first blood pipeline is connected out from the artery of the human body, the blood pump is wound, one membrane joint of the dialyzer is connected, the anticoagulant pump is connected into the first blood pipeline, and the second blood pipeline is connected into the vein of the human body from the other membrane joint of the dialyzer.
3. A blood purification method facilitating improvement of purification efficiency according to claim 1, wherein: in the step S1, a dialysate pipeline is connected out from an external dialysate bag, and is connected into an external membrane joint of the dialyzer after passing through a dialysate/substitution liquid pump and a dialysate/substitution liquid flow detector.
4. A blood purification method facilitating improvement of purification efficiency according to claim 1, wherein: in the step S1, harmful and redundant metabolic wastes and excessive electrolytes in blood are removed from the body by utilizing the semi-permeable membrane principle, so that the purpose of purifying the blood is achieved, and the purposes of correcting water electrolyte and acid-base balance are achieved.
5. A blood purification method facilitating improvement of purification efficiency according to claim 1, wherein: in the step S2, the perfusion device is firstly arranged on the filter fixing clamp, then the first blood pipeline is connected out from the artery of the human body, the blood is connected into one joint of the perfusion device by the blood circulating pump, so that the blood is contacted with an adsorption layer in the perfusion device, and the perfusion device can be used for removing certain metabolic products and exogenous medicines or poisons in the body, the anticoagulant pump is connected into the first blood pipeline, and the second blood pipeline is connected into the vein of the human body from the other joint of the perfusion device.
6. A blood purification method facilitating improvement of purification efficiency according to claim 1, wherein: the adsorption layer in the S2 can be one or two of resin and active carbon adsorption layer in the HA resin hemoperfusion apparatus.
7. A blood purification method facilitating improvement of purification efficiency according to claim 1, wherein: in the step S3, the dialyzer is firstly arranged on the filter fixing clamp, then the first blood pipeline is connected out from the artery of the human body, the blood pump is wound, one membrane joint of the dialyzer is connected, the anticoagulant pump is connected into the first blood pipeline, the second blood pipeline is connected into the vein of the human body from the other membrane joint of the dialyzer, the ion filter pipe is connected into the other membrane joint of the dialyzer, and the dialyzer can be used for separating and decomposing metabolic waste ions, and the second blood pipeline is connected into the vein of the human body from the other membrane joint of the ion filter pipe.
8. A blood purification method facilitating improvement of purification efficiency according to claim 1, wherein: in the step S4, the dialyzer is firstly arranged on the filter fixing clamp, then the external replacement liquid bag is hung on the liquid support, then the first blood pipeline is connected out from the artery of the human body, the blood pump is wound, the first membrane joint of the dialyzer is connected, the semipermeable membrane structure and the macromolecular isolation layer in the dialyzer can be used for filtering and isolating harmful substances, the anticoagulant pump is connected into the first blood pipeline, and the second blood pipeline is connected into the vein of the human body from the second membrane joint of the dialyzer.
9. A blood purification method facilitating improvement of purification efficiency according to claim 1, wherein: and S4, connecting the replacement liquid pipeline out of the external replacement liquid bag, directly connecting a first membrane joint of the dialyzer after passing through a dialysate/replacement liquid pump and a dialysate/replacement liquid flow detector or connecting the first membrane joint of the filter after connecting the first blood pipeline.
10. A blood purification method facilitating improvement of purification efficiency according to claim 1, wherein: in the S1, a waste liquid pipeline is connected out from the other external membrane connector of the dialyzer and is connected into an external waste liquid container through a blood leakage detector, a waste liquid pump and a waste liquid flow detector, and in the S2 and the S4, the waste liquid pipeline is connected out from the one external membrane connector of the dialyzer and is connected into the external waste liquid container through the blood leakage detector, the waste liquid pump and the waste liquid flow detector.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410019994.5A CN117797352A (en) | 2024-01-06 | 2024-01-06 | Blood purification method convenient for improving purification efficiency |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410019994.5A CN117797352A (en) | 2024-01-06 | 2024-01-06 | Blood purification method convenient for improving purification efficiency |
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| Publication Number | Publication Date |
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| CN117797352A true CN117797352A (en) | 2024-04-02 |
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| CN202410019994.5A Pending CN117797352A (en) | 2024-01-06 | 2024-01-06 | Blood purification method convenient for improving purification efficiency |
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| Country | Link |
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| CN (1) | CN117797352A (en) |
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- 2024-01-06 CN CN202410019994.5A patent/CN117797352A/en active Pending
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