CN105572488B - For detecting system and production method of the transcranial magnetic stimulation in encephalic induction field - Google Patents
For detecting system and production method of the transcranial magnetic stimulation in encephalic induction field Download PDFInfo
- Publication number
- CN105572488B CN105572488B CN201511035157.9A CN201511035157A CN105572488B CN 105572488 B CN105572488 B CN 105572488B CN 201511035157 A CN201511035157 A CN 201511035157A CN 105572488 B CN105572488 B CN 105572488B
- Authority
- CN
- China
- Prior art keywords
- imitates
- model
- imitate
- brain
- magnetic stimulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000011491 transcranial magnetic stimulation Methods 0.000 title claims abstract description 69
- 230000006698 induction Effects 0.000 title claims abstract description 38
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 15
- 210000003128 head Anatomy 0.000 claims abstract description 100
- 210000004556 brain Anatomy 0.000 claims abstract description 76
- 210000004761 scalp Anatomy 0.000 claims abstract description 68
- 230000005684 electric field Effects 0.000 claims abstract description 46
- 238000001514 detection method Methods 0.000 claims abstract description 39
- 239000000523 sample Substances 0.000 claims abstract description 36
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims abstract description 30
- 210000003625 skull Anatomy 0.000 claims abstract description 21
- 238000004804 winding Methods 0.000 claims abstract description 19
- 239000000463 material Substances 0.000 claims description 21
- 210000001178 neural stem cell Anatomy 0.000 claims description 10
- 238000002347 injection Methods 0.000 claims description 8
- 239000007924 injection Substances 0.000 claims description 8
- 238000010146 3D printing Methods 0.000 claims description 3
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- 210000001259 mesencephalon Anatomy 0.000 claims description 3
- 210000005036 nerve Anatomy 0.000 claims description 3
- 238000012545 processing Methods 0.000 claims description 3
- 239000007779 soft material Substances 0.000 claims description 3
- 238000007711 solidification Methods 0.000 claims description 3
- 230000008023 solidification Effects 0.000 claims description 3
- 238000003860 storage Methods 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 2
- 238000005259 measurement Methods 0.000 abstract description 8
- 238000000034 method Methods 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 7
- 238000010586 diagram Methods 0.000 description 6
- 239000003822 epoxy resin Substances 0.000 description 5
- 229920000647 polyepoxide Polymers 0.000 description 5
- 239000011780 sodium chloride Substances 0.000 description 5
- 238000009826 distribution Methods 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- 108010010803 Gelatin Proteins 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 229920000159 gelatin Polymers 0.000 description 3
- 239000008273 gelatin Substances 0.000 description 3
- 235000019322 gelatine Nutrition 0.000 description 3
- 235000011852 gelatine desserts Nutrition 0.000 description 3
- 239000010439 graphite Substances 0.000 description 3
- 229910002804 graphite Inorganic materials 0.000 description 3
- 239000010440 gypsum Substances 0.000 description 3
- 229910052602 gypsum Inorganic materials 0.000 description 3
- 230000004936 stimulating effect Effects 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 229920002379 silicone rubber Polymers 0.000 description 2
- ZYUVGYBAPZYKSA-UHFFFAOYSA-N 5-(3-hydroxybutan-2-yl)-4-methylbenzene-1,3-diol Chemical compound CC(O)C(C)C1=CC(O)=CC(O)=C1C ZYUVGYBAPZYKSA-UHFFFAOYSA-N 0.000 description 1
- 241000219109 Citrullus Species 0.000 description 1
- 235000012828 Citrullus lanatus var citroides Nutrition 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- PASHVRUKOFIRIK-UHFFFAOYSA-L calcium sulfate dihydrate Chemical compound O.O.[Ca+2].[O-]S([O-])(=O)=O PASHVRUKOFIRIK-UHFFFAOYSA-L 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000003710 cerebral cortex Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000001054 cortical effect Effects 0.000 description 1
- 210000003792 cranial nerve Anatomy 0.000 description 1
- NHADDZMCASKINP-HTRCEHHLSA-N decarboxydihydrocitrinin Natural products C1=C(O)C(C)=C2[C@H](C)[C@@H](C)OCC2=C1O NHADDZMCASKINP-HTRCEHHLSA-N 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000003760 magnetic stirring Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 230000001272 neurogenic effect Effects 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000008844 regulatory mechanism Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000003936 working memory Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R29/00—Arrangements for measuring or indicating electric quantities not covered by groups G01R19/00 - G01R27/00
- G01R29/12—Measuring electrostatic fields or voltage-potential
- G01R29/14—Measuring field distribution
Landscapes
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Magnetic Treatment Devices (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Abstract
It is a kind of to be used to detect system and production method of the transcranial magnetic stimulation in encephalic induction field, include transcranial magnetic stimulation device and oscillograph, head model imitates body, the electric field detection probe of body signal and caliberating device for being demarcated to electric field detection probe are imitated for gathering head model, head model is imitated body and is arranged on by fixing device in caliberating device, the output winding of transcranial magnetic stimulation device be arranged on the bottom of caliberating device and imitated with head model body bottom it is tangent, electric field detection probe is fixed on the coordinatometer on caliberating device top, the signal acquisition terminal connection head model of electric field detection probe imitates body, the output terminal of electric field detection probe connects oscillograph by conducting wire.Brain imitates the thickness of body as 70~80mm, and cerebrospinal fluid imitates the thickness of body as 3~6mm, and skull imitates the thickness of body as 4~6.5mm, and the thickness that scalp layer imitates body is 5~8mm.The present invention can be with higher spatial resolution, the encephalic induction field of accurate measurement transcranial magnetic stimulation induction.
Description
Technical field
The present invention relates to a kind of devices for detecting transcranial magnetic stimulation in encephalic induction field.Brain is included more particularly to one kind
Ditch return structure four layers of head model imitate body for detecting system and production method of the transcranial magnetic stimulation in encephalic induction field.
Background technology
Transcranial magnetic stimulation is a kind of cranial nerve stimulating technology of Barker of Xie Feier universities of Britain in 1985 et al. inventions,
Its principle is to act on cerebral cortex using time-varying magnetic field, changes the dynamic of cortical neurogenic cell so as to generate induction field in encephalic
Make current potential, influence the biostimulation technology of intracerebral metabolism and neural electrical activity, there is noninvasive, safety, skull can be penetrated into assassination
It the advantages of sharp and targeting, is now widely used in the important brain science research such as working memory mechanism, emotion regulatory mechanism.
And in transcranial magnetic stimulation, it is that it is basic what is played a role in the electric field strength for the induction field that encephalic generates
Reason.However, the measurement of the electric field strength is always researcher's issues that need special attention.At present, mainly by following several through cranium
Neural stem cell encephalic induction field measuring method, first, using the method for emulation, by establishing artificial head model and through cranium magnetic
Stimulating coil model is stimulated, excitation parameters are set, carries out the detection of encephalic induction field spatial distribution.This kind of method can construct
More fine head model, but it is a kind of method based on computer and correlation computations software, and calculating process is carried out
Certain simplification, there are calculation errors.Second, half unbounded space is simulated using the method for saline slot and carries out electric field strength space point
The detection of cloth can illustrate the induction field spatial distribution of transcranial magnetic stimulation to a certain extent.However, people is simulated using saline slot
Head accuracy is relatively low, the big limitation of measurement error.Main cause is saline slot from shape to CONSTRUCTED SPECIFICATION and electrical conductivity
Characteristic has very big difference with real head part.In addition, a few studies person is implanted into using invasive method on cortex surface
Detecting electrode detects the spatial distribution for the induction field that transcranial magnetic stimulation is generated in encephalic.This kind of method is invasive, is existed
Some potential safety problems, and the spatial resolution of encephalic piezomagnetic theory is influenced by implant electrode quantity and number, is caused
The spatial resolution of its detection electric field is relatively low, therefore, develops a kind of head mould similar to true head part in structure and electrical conductivity
Type, as research tool, the piezomagnetic theory of detection transcranial magnetic stimulation generation is applied to brain science for transcranial magnetic stimulation
Research certain guidance and help are provided, have great importance.
The content of the invention
A kind of measurement the technical problem to be solved by the invention is to provide pinpoint accuracy, high spatial resolution is through cranium magnetic
What stimulation induction encephalic electric field was distributed is used to detect system and production method of the transcranial magnetic stimulation in encephalic induction field.
The technical solution adopted in the present invention is：It is a kind of to be used to detect system of the transcranial magnetic stimulation in encephalic induction field,
Include transcranial magnetic stimulation device and oscillograph, be additionally provided with head model imitate body, for gather head model imitate body signal electric field inspection
Probing pin and the caliberating device for being demarcated to electric field detection probe, wherein, the head model is imitated body and is filled by fixed
It puts and is arranged in the caliberating device, the output winding of the transcranial magnetic stimulation device is arranged on the bottom of the caliberating device simultaneously
Imitate that the bottom of body is tangent with head model, the electric field detection probe is fixed on the coordinatometer on the caliberating device top, electric field
The signal acquisition terminal of detection probe connects the head model and imitates body, and the output terminal of the electric field detection probe is shown by conducting wire connection
Ripple device.
The caliberating device includes：For head model to be set to imitate the housing of body, the upper port of the housing is for inside
Hatch frame, the described coordinatometer for the electric field detection probe to be fixed and demarcated are arranged on the housing
In upper port, Neural stem cell port is formed in the bottom of the housing, for set imitate head model that body stimulated through cranium
The output winding of magnetic stimulator, the periphery of the Neural stem cell port be formed with can run through transcranial magnetic stimulation device and output winding it
Between conducting wire groove.
The coordinatometer includes：Both ends are arranged on two symmetrical sides of housing upper port and can be along described
The X-axis scale that moves horizontally of the two sides, the Y being arranged on the side perpendicular with the X-axis scale of the housing
Axis scale and the Z axis scale being arranged on the X-axis scale perpendicular with the X-axis scale and Y-axis scale respectively,
The Z axis scale can move up and down under the support of X-axis scale, and the top of the electric field detection probe is by being arranged on Z axis
Fixing piece on scale is fixed on the Z axis scale, and the lower end of the electric field detection probe, which is inserted into, is arranged on the mark
The in vivo head model of shell for determining device is imitated in body.
The fixing device, which is provided in the housing of the caliberating device, is used to support the branch that the head model imitates body
Fagging is provided in the support plate to be embedded in the embedded hole that head model imitates body, and the diameter of the embedded hole is less than the head mould
Type imitates the diameter of body, and can make head model imitate body bottom vertex and transcranial magnetic stimulation device output winding it is tangent；Or institute
The fixing device stated is can be embedded in and be located in the in vivo head model being made of soft material of shell of the caliberating device to imitate
Body fixed body has to install the head model along the formation of the central shaft up/down perforation of the head model fixed body and imitates the logical of body
Hole, when the head model imitates body in the through hole, the head model is imitated body and can be located in the through hole, and
Head model imitate body bottom vertex and transcranial magnetic stimulation device output winding it is tangent.
The head model imitates body as semicircle sphere structure, and by inboard, to being orderly arranged outside each, brain imitates body, cerebrospinal fluid is imitated
Body, skull imitate body and scalp layer imitates body, and the outer circumferential surface that the brain imitates body is formed with emulation ditch time structure, and the cerebrospinal fluid imitates body
Medial surface and the brain imitate the emulation ditch of external circumferential surface and return structure and match, the signal acquisition terminal of the electric field detection probe
It is inserted into brain to imitate in body, the output winding of the transcranial magnetic stimulation device corresponds to the scalp layer and imitates body.
The head model is imitated in body：Brain imitates the thickness of body as 70~80mm, and cerebrospinal fluid imitates the thickness of body as 3~6mm, cranium
Bone imitates the thickness of body as 4~6.5mm, and the thickness that scalp layer imitates body is 5~8mm.
In the case where the output frequency of transcranial magnetic stimulation device is 3k~4kHz, the head model imitates body midbrain and imitates body, cerebrospinal fluid
Imitative body, skull imitate body and scalp layer imitates the electrical conductivity of body and corresponds to 0.1~0.3S/m, 2~4S/m, 0.01~0.03S/ respectively
M, 0.25~0.35S/m.
It is a kind of to be used to detect the production method that head model of the transcranial magnetic stimulation in the system of encephalic induction field imitates body, it wraps
Include following steps：
1) scalp layer is made respectively imitate body and brain model, wherein, the scalp layer imitates the thickness of body as 5~8mm, the brain
The thickness of model is 70~80mm, and 2 are each provided on body and brain model at corresponding position including being imitated respectively in scalp layer
The first above fixed column, wherein, the first fixed column that scalp layer imitates on body is the setting that can be dismantled；
2) the inner surface smearing skull layer that body is imitated in the cortex made imitates body thickness as 4~6.5mm；
3) brain model is put into inner surface smears skull layer and imitate the scalp layer of body and imitate internal side, and make first on brain model
Fixed column imitated with scalp layer the first fixed column on body it is corresponding on, scalp layer is imitated into body and brain model using the first geometrical clamp respectively
Upper two corresponding the first fixed columns clamp, so that the brain model and the scalp layer are formed with 3 between imitating body
The gap of~6mm；
4) imitate injection cerebrospinal fluid in gap between body in the brain model and the scalp layer and imitate body material, use
Ultrasonator is removed the processing of bubble, is then placed in refrigerator cold-storage；
5) cerebrospinal fluid, which is imitated to be formed with ditch after body material cooled and solidified and return the cerebrospinal fluid of structure, imitates body, remove scalp layer imitate body and
The first geometrical clamp and scalp layer on brain model imitate the first fixed column on body, take out brain model, internal note is imitated in cerebrospinal fluid
Enter brain and imitate the material of body to obtain head model and imitate body.
Brain model described in step 1 is made using standard brain 3D printing, specifically using Mimics to standard
Typical AVM image carries out 3 D stereo modeling, generates STl documents, is printed using 3D printer, and Plays brain is used plus taken
The MRI brain maps of big Montreal nerve institute, uniformly installed on the periphery for the brain model upper surface made 2 or more the
One fixed column.
It is to imitate mould using scalp layer to make that scalp layer described in step 1, which imitates body, and the scalp layer imitates mould
Including external mold and internal model, the external mold is the semicircular shell that radius is 82~100mm, the internal model is radius for 77~
The hemisphere of 95mm is each provided with 2 or more at the corresponding position in the periphery of the upper surface of the external mold and internal model upper surface
The second fixed column, internal model is put into the inside of external mold, and make the gap that 5~8mm is formed between internal model and external mold, and made outer
On the second fixed column on mould is corresponding with the second fixed column in internal model, respectively using the second geometrical clamp by institute on external mold and internal model
Corresponding two the second fixed columns clamp, and injection head cortex imitates body material in the gap between the external mold and the internal model
Material after scalp layer imitates body material solidification, removes the second geometrical clamp on external mold and internal model, and taking-up is formed between external mold and internal model
Coagulum, be scalp layer imitate body.
The present invention for detecting system and production method of the transcranial magnetic stimulation in encephalic induction field, be a kind of high precision
The device that degree, the measurement transcranial magnetic stimulation induction encephalic electric field of high spatial resolution are distributed, it is contemplated that the electricity of different head structure
Conductance characteristic makes the head model for including scalp, skull, cerebrospinal fluid and the imitative body material of four kinds of brain, to the full extent approaching to reality
The head of people.It can be induced using the device of the invention with higher spatial resolution, accurate measurement transcranial magnetic stimulation
Encephalic induction field.The production method of head model is simple in the device of the invention, can obtain different parameters transcranial magnetic stimulation and swash
Encourage the spatial distribution of lower encephalic induction field intensity, can be used for for transcranial magnetic stimulation related brain science research provide it is valuable
Guidance, and security of the transcranial magnetic stimulation in application can be improved to a certain extent.
Description of the drawings
Fig. 1 is that the present invention is integrally formed block diagram；
Fig. 2 is the structure diagram of caliberating device in the present invention；
Fig. 3 is the bottom view of caliberating device in the present invention；
Fig. 4 is the structure diagram for the support plate being arranged in the present invention in caliberating device；
Fig. 5 is the structure diagram of fixing device in the present invention；
Fig. 6 is the structure diagram of electric field detection probe in the present invention；
Fig. 7 is the structure schematic top plan view that head model imitates body in the present invention；
Fig. 8 is the sectional view of Fig. 7；
Fig. 9 is that the schematic diagram that the cerebrospinal fluid for having ditch to return structure imitates body method is made in the present invention；
Figure 10 is the sectional view of Fig. 9；
Figure 11 is to be used to make the schematic top plan view that scalp layer imitates mould in the present invention；
Figure 12 is the sectional view of Figure 11.
In figure
1：Transcranial magnetic stimulation device 2：Head model imitates body
21：Brain imitates body 22：Cerebrospinal fluid imitates body
23：Skull imitates body 24：Scalp layer imitates body
25：It emulates ditch and returns structure 26：Brain model
3：Electric field detection probe 4：Oscillograph
5：Fixing device 51：Head model imitates body fixed body
52：Through hole 6：Caliberating device
61：Housing 611：X-axis scale
612：Y-axis scale 613：Z axis scale
614：Fixing piece 62：Coordinatometer
63：Neural stem cell port 64：Groove
65：Support plate 66：Embedded hole
7：Output winding 8：External mold
9：Internal model 10：First fixed column
11：First geometrical clamp 12：Second fixed column
13：Second geometrical clamp
Specific embodiment
The a kind of of the present invention is used to detect transcranial magnetic stimulation in encephalic induction field with reference to embodiment and attached drawing
System and production method are described in detail.
As shown in Figure 1, the present invention for detecting system of the transcranial magnetic stimulation in encephalic induction field, include through cranium magnetic
Stimulator 1 and oscillograph 4, which is characterized in that be additionally provided with head model and imitate body 2, for gathering the electric field that head model imitates 2 signal of body
Detection probe 3 and the caliberating device 6 for being demarcated to electric field detection probe 3, wherein, the head model is imitated body 2 and is passed through
Fixing device 5 is arranged in the caliberating device 6, and the output winding 7 of the transcranial magnetic stimulation device 1 is arranged on the calibration dress
The bottom put 6 bottom and body 2 is imitated with head model is tangent, and the electric field detection probe 3 is fixed on 6 top of caliberating device
On coordinatometer 62, the signal acquisition terminal of electric field detection probe 3 connects the head model and imitates body 2, the electric field detection probe 3 it is defeated
Outlet connects oscillograph 4 by conducting wire.
As shown in Figure 2 and Figure 3, the caliberating device 6 includes：Inside is used for the housing 61 that head model is set to imitate body 2,
The upper port of the housing 61 is hatch frame, the described seat for the electric field detection probe 3 to be fixed and demarcated
Scale 62 is arranged in the upper port of the housing 61, Neural stem cell port 63 is formed in the bottom of the housing 61, for setting
Put the output winding 7 that the transcranial magnetic stimulation device 1 that body 2 is stimulated is imitated head model, the periphery of the Neural stem cell port 63 is formed
The groove 64 of the conducting wire between transcranial magnetic stimulation device 1 and output winding 7 can be run through by having.
As shown in Fig. 2, the coordinatometer 62 includes：Both ends are arranged on two symmetrical sides of 61 upper port of housing
X-axis scale 611 that is upper and being moved horizontally along the two described sides is being arranged on the housing 61 with the X-axis mark
Y-axis scale 612 on the perpendicular side of ruler 611 and perpendicular with the X-axis scale 611 and Y-axis scale 612 respectively
The Z axis scale 613 being arranged on the X-axis scale 611, the Z axis scale 613 can be under the support of X-axis scale 611 on
Lower movement, the top of the electric field detection probe 3 are fixed on the Z by the fixing piece 614 being arranged on Z axis scale 613
On axis scale 613, the lower end of the electric field detection probe 3 is inserted into the head mould being arranged in the housing 61 of the caliberating device 6
Type is imitated in body 2.
As shown in figure 4, the fixing device 5, which is provided in the housing of the caliberating device 6, is used to support the head
Model imitates the support plate 65 of body 2, is provided with to be embedded in the embedded hole 66 that head model imitates body 2, the insertion in the support plate 65
The diameter in hole 66 imitates the diameter of body 2 less than the head model, and head model can be made to imitate vertex and the transcranial magnetic stimulation of 2 bottom of body
The output winding 7 of device 1 is tangent；
Or as shown in figure 5, the fixing device 5 is can be embedded in and be located in the housing 61 of the caliberating device 6
The interior head model being made of soft material imitates body fixed body 51, and the central shaft that body fixed body 51 is imitated along the head model passes through up and down
Logical formation has to install the through hole 52 that the head model imitates body 2, and the head model imitates body 2 in the through hole 52
When, the head model is imitated body 2 and can be located in the through hole 52, and head model imitates the vertex of 2 bottom of body with being pierced through cranium magnetic
The output winding 7 for swashing device 1 is tangent.
As shown in Figure 7, Figure 8, the head model imitates body 2 as semicircle sphere structure, by inboard to being orderly arranged outside each
Brain imitates body 21, cerebrospinal fluid imitates body 22, skull imitates body 23 and scalp layer imitates body 24, the brain imitate body 21 outer circumferential surface be formed with it is imitative
True ditch returns structure 25, and the cerebrospinal fluid imitates the medial surface of body 22 and the brain imitates emulation ditch time 25 kissing of structure of 21 outer circumferential surface of body
It closes, the signal acquisition terminal of the electric field detection probe 3 is inserted into brain and imitates in body 21, the output line of the transcranial magnetic stimulation device 1
Circle 7 corresponds to the scalp layer and imitates body 24.
The head model is imitated in body 2：Brain imitates the thickness of body 21 as 70~80mm, cerebrospinal fluid imitate the thickness of body 22 for 3~
6mm, skull imitate the thickness of body 23 as 4~6.5mm, and the thickness that scalp layer imitates body 24 is 5~8mm.
In the case where the output frequency of transcranial magnetic stimulation device 1 is 3k~4kHz, the head model imitates 2 midbrain of body and imitates body 21, brain
Spinal fluid imitates body 22, skull imitates body 23 and scalp layer imitate body 24 electrical conductivity correspond to respectively 0.1~0.3S/m, 2~4S/m,
0.01~0.03S/m, 0.25~0.35S/m.
As shown in Figure 9, Figure 10, it is of the invention for detecting head mould of the transcranial magnetic stimulation in the system of encephalic induction field
The production method that type imitates body, includes the following steps：
1) scalp layer is made respectively imitate body 24 and brain model 26, wherein, the scalp layer imitates the thickness of body 24 as 5~8mm,
The thickness of the brain model 26 is 70~80mm, including being imitated respectively in scalp layer on body 24 and brain model 26 at corresponding position
First fixed column 10 of 2 or more is each provided with, wherein, the first fixed column (10) that scalp layer is imitated on body (24) is can to dismantle
Setting；
The brain model 26 is made using standard brain 3D printing, specifically using Mimics to standard Typical AVM
Image carries out 3 D stereo modeling, generates STl documents, is printed using 3D printer, and Plays brain is covered using Canada
The MRI brain maps of Paul Tellier nerve institute (MNI), in the uniformly installation 2 or more of the periphery for 26 upper surface of brain model made
The first fixed column 10.
As shown in Figure 11, Figure 12, it is to imitate mould using scalp layer to make that the scalp layer described in step 1), which imitates body 24, institute
The scalp layer stated imitates mould and includes external mold 8 and internal model 9, and the external mold 8 is the semicircle shell that radius is 82~100mm
Body, the internal model 9 is the hemisphere that radius is 77~95mm, on the periphery of 9 upper surface of the upper surface of the external mold 8 and internal model
Second fixed column 12 of 2 or more is each provided at corresponding position, internal model 9 is put into the inside of external mold 8, and make internal model 9 with
The gap of 5~8mm is formed between external mold 8, and makes the second fixed column 12 on external mold 8 and the second fixed column 12 in internal model 9
In correspondence, two the second fixed columns 12 corresponding on external mold 8 and internal model 9 are clamped using the second geometrical clamp 13 respectively, in institute
Injection head cortex imitates body material in gap between the external mold 8 stated and the internal model 9, after scalp layer imitates body material solidification, tears open
The second geometrical clamp 13 on lower external mold 8 and internal model 9 takes out the coagulum being formed between external mold 8 and internal model 9, is scalp layer
Imitative body 24.
2) the inner surface smearing skull layer that body 24 is imitated in the cortex made imitates 23 thickness of body as 4~6.5mm；
3) brain model 26 is put into inner surface smears skull layer and imitate the scalp layer of body 23 and imitate the inside of body 24, and make brain model 26
On the first fixed column 10 and scalp layer imitate the first fixed column 10 on body 24 it is corresponding on, respectively using the first geometrical clamp 11 by head
Cortex is imitated on body 24 and brain model 26 two corresponding the first fixed columns 10 and is clamped so that the brain model 26 with it is described
Scalp layer imitate the gap that 3~6mm is formed between body 24；
4) imitate injection cerebrospinal fluid in gap between body 24 in the brain model 26 and the scalp layer and imitate body material,
The processing of bubble is removed using ultrasonator, is then placed in refrigerator cold-storage；
5) cerebrospinal fluid, which is imitated to be formed with ditch after body material cooled and solidified and return the cerebrospinal fluid of structure, imitates body 22, removes scalp layer and imitates body
24 and the first geometrical clamp 11 on brain model 26 and scalp layer imitate the first fixed column 10 on body 24, take out brain model 26,
Cerebrospinal fluid, which imitates injection brain in body 22 and imitates the material of body 21, to be obtained head model and imitates body 2.
In an embodiment of the present invention：
The scalp layer imitates body 24, is made by epoxy resin and electrically conductive graphite, absolute ethyl alcohol is added to double
It dilutes in phenol A type epoxy resin, is stirred using electric blender.Electrically conductive graphite is added in diluted epoxy resin,
It is stirred using electric blender, is uniformly mixed, is then added to scalp layer and imitates in mould, excluded by supersonic oscillations
Bubble is put into insulating box and is cured, and temperature setting is 200 °, cures 8 hours, then demoulds, and then forms scalp layer and imitates
Body 24.Epoxy resin, curing agent, absolute ethyl alcohol, the mass ratio of graphite are 40:10:6:3.Remaining conductive epoxy resin is cut
Into 3 pieces of length and widths, it is high be respectively 10mm, 10mm, 5mm cuboid, use Agilent impedance analyzer 4294A and matched
16451B fixtures measure the electrical conductivity of 3 pieces of field cubes, in output frequency 3k~4kHz of Magstim transcranial magnetic stimulation devices, survey
Amount is averaged three times, is obtained scalp layer and is imitated the electrical conductivity of body as 0.25~0.35S/m.
The skull layer imitates body 23, is made by mixing by gypsum and pure water, and pigment quality is weighed using electronic balance
Than for 0.35：1 pure water and land plaster is mixed rapidly uniformly using stirring rod, watermelon is applied to using flat spoon
The inner surface of skin, smearing thickness 7.5mm, gypsum normal temperature cure are polished using fine sandpaper, are formed skull layer and are imitated body.It adopts
With the proportioning that the identical gypsum of body and pure water are imitated with skull layer, using the square grinding tool of silicon rubber, make 3 piece of 3 block length,
Wide, high is respectively the square of 10mm, 10mm, 5mm, after curing the demoulding, using Agilent impedance analyzer 4294A and with its
The 16451B fixtures matched somebody with somebody measure the electrical conductivity of 3 pieces of squares, in the output frequency of Britain's Magstim transcranial magnetic stimulation devices
3571Hz, measurement are averaged three times, are obtained scalp layer and are imitated the electrical conductivity of body as 0.01~0.03S/m.
The cerebrospinal fluid imitates body 22, is to be made by the way of perfusion by gelatin and pure water, concretely comprises the following steps：
Pure water is heated to 60 DEG C using constant temperature blender with magnetic force, gelatin is then slowly added into, is sufficiently stirred using magnetic stirring apparatus
Uniformly, 85 DEG C are heated to and, cools down and solidifies, the quality proportioning of gelatin and pure water is 0.02:1.Use the pros of silicon rubber
Body grinding tool, the square of 3 pieces of 3 pieces of length and widths of body material making, high respectively 10mm, 10mm, 5mm are imitated using cerebrospinal fluid, and cooling is solid
After changing the demoulding, the conductance of 3 pieces of squares is measured using Agilent impedance analyzer 4294A and matched 16451B fixtures
Rate, in the output frequency 3k-4kHz of transcranial magnetic stimulation device, measurement is averaged three times, obtain cerebrospinal fluid imitate the electrical conductivity of body for 2~
4S/m。
The brain imitates body 21, is by sodium chloride and pure water mixing, be sufficiently stirred being made, sodium chloride and pure
The quality proportioning of water purification is 0.0085~0.0092:1.Its electrical conductivity is measured using liquid electric conductivity tester, is obtained
The electrical conductivity that brain imitates body is 0.1~0.3S/m.
It is described imitated for gland model 2 body fixing device 5 be use by highly for 150mm, length 300mm,
Width imitates body fixed body 51 for head model made of the cuboid sponge material of 300mm, will be fabricated to height with scissors inside it
Head model can be imitated body and be fixed, prevent its movement by the cylindrical hole 52 of 150mm, a diameter of 190mm.
The head model position label means 6 are made of pmma material, and shape is respectively for length
The square shape of 300mm, 300mm, 300mm, for the square without upper surface, it is respectively 200mm*100mm that, which there is size in lower surface,
Oblong openings, stimulate eight wordline circles used for placing transcranial magnetic stimulation, coil made to imitate the top of body bottom with head model
Point is tangent, the rectangle side opening that size is 60mm*100mm is provided in oblong openings one side, for placing transcranial magnetic stimulation
The conducting wire of eight wordline circles of device.X, Y and the minimum scale of the scale in 3 directions of Z axis that caliberating device 6 contains be 1mm, three sides
It can move freely to scale, be fixed by the screw of pmma material.
The transcranial magnetic stimulation device 1 is to be pierced using the Magstim rapid2 of Magstim companies of Britain production through cranium magnetic
Swash device, stimulating coil uses the eight wordline circles to match with the magnetic stimulator.The electric field detection probe is that outer diameter is 3mm's
Coaxial cable is respectively 3mm using the conducting wire of its inside and outside as the distance between the two poles of the earth of probe in detecting, the two poles of the earth.
Oscillograph 4 uses Tyke oscillograph DPO2024, is connected to the both ends of electric field detection probe, is passed through under synchronous recording
Cranium Neural stem cell stimulates the electric field strength of induction to react the voltage value U on oscillograph.Due to the two poles of the earth distance of electric field detection probe
For d=3mm, thus it can be assumed that the induction of a small range transcranial magnetic stimulation electric field be it is uniform, therefore, electric field strength E's
Calculating can carry out conversion acquisition by the voltage value U recorded on oscillograph, and calculation formula is：
E=U/d
The present invention for detecting system and production method of the transcranial magnetic stimulation in encephalic induction field, establish containing ditch
Four layers of head model of structure are returned, for the predicament that current transcranial magnetic stimulation is measured in encephalic induction field, making approaches true
The electrical conductivity of head and the imitative body head model of anatomical structure measure transcranial magnetic stimulation encephalic induction field, can be speculated with this
Different parameters transcranial magnetic stimulation, such as different stimulated intensity in the induction field that encephalic generates, estimate the warp that different normal forms export
The effect that cranium Neural stem cell generates encephalic difference brain structure so as to instruct the parameter setting of correlation test, exists for transcranial magnetic stimulation
Application in brain science provides help, and can improve security of the transcranial magnetic stimulation in application to a certain extent.
Claims (8)
1. it is a kind of for detecting system of the transcranial magnetic stimulation in encephalic induction field, include transcranial magnetic stimulation device (1) and oscillography
Device (4), which is characterized in that be additionally provided with head model imitate body (2), for gather head model imitate body (2) signal electric field detect visit
Pin (3) and the caliberating device (6) for being demarcated to electric field detection probe (3), wherein, it is logical that the head model imitates body (2)
It crosses fixing device (5) to be arranged in the caliberating device (6), the output winding (7) of the transcranial magnetic stimulation device (1) is arranged on
The bottom of the caliberating device (6) and imitated with head model body (2) bottom it is tangent, the electric field detection probe (3) is fixed on institute
On the coordinatometer (62) for stating caliberating device (6) top, the signal acquisition terminal of electric field detection probe (3) connects the head model and imitates body
(2), the output terminal of the electric field detection probe (3) connects oscillograph (4) by conducting wire；
The head model imitates body (2) as semicircle sphere structure, and body (21), cerebrospinal fluid are imitated to being orderly arranged outside each brain by inboard
Imitative body (22), skull imitate body (23) and scalp layer imitates body (24), and the outer circumferential surface that the brain imitates body (21) is formed with emulation ditch time
Structure (25), the cerebrospinal fluid imitates the medial surface of body (22) and the brain imitates emulation ditch time structure (25) phase of body (21) outer circumferential surface
It coincide, the signal acquisition terminal of the electric field detection probe (3) is inserted into brain and imitates in body (21), the transcranial magnetic stimulation device (1)
The corresponding scalp layer of output winding (7) imitate body (24), the head model is imitated in body (2)：The thickness that brain imitates body (21) is
70~80mm, cerebrospinal fluid imitate the thickness of body (22) as 3~6mm, and skull imitates the thickness of body (23) as 4~6.5mm, and scalp layer imitates body
(24) thickness is 5~8mm.
2. according to claim 1 be used to detect system of the transcranial magnetic stimulation in encephalic induction field, which is characterized in that institute
The caliberating device (6) stated includes：Inside is used for the housing (61) that head model is set to imitate body (2), the upper end of the housing (61)
Mouthful for hatch frame, the described coordinatometer (62) for the electric field detection probe (3) to be fixed and demarcated is arranged on
In the upper port of the housing (61), Neural stem cell port (63) is formed in the bottom of the housing (61), for setting enemy
Model imitates the output winding (7) for the transcranial magnetic stimulation device (1) that body (2) is stimulated, the periphery shape of the Neural stem cell port (63)
It can be through the groove (64) of the conducting wire between transcranial magnetic stimulation device (1) and output winding (7) into having.
3. according to claim 1 or 2 for detecting system of the transcranial magnetic stimulation in encephalic induction field, feature exists
In the coordinatometer (62) includes：Both ends are arranged on two symmetrical sides of housing (61) upper port and being capable of edges
The X-axis scale (611) that the two described sides move horizontally is being arranged on the housing (61) with the X-axis scale (611)
Y-axis scale (612) on perpendicular side and perpendicular with the X-axis scale (611) and Y-axis scale (612) respectively
The Z axis scale (613) being arranged on the X-axis scale (611), the Z axis scale (613) can be in X-axis scale (611)
It is moved up and down under support, the top of the electric field detection probe (3) passes through the fixing piece (614) that is arranged on Z axis scale (613)
It is fixed on the Z axis scale (613), the lower end of the electric field detection probe (3), which is inserted into, is arranged on the caliberating device
(6) the head model in housing (61) is imitated in body (2).
4. according to claim 1 be used to detect system of the transcranial magnetic stimulation in encephalic induction field, which is characterized in that institute
The fixing device (5) stated, which is provided in the housing of the caliberating device (6), is used to support the support that the head model imitates body (2)
Plate (65) is provided with to be embedded in the embedded hole (66) that head model imitates body (2) on the support plate (65), the embedded hole (66)
Diameter imitates the diameter of body (2) less than the head model, and head model can be made to imitate the vertex and transcranial magnetic stimulation device of body (2) bottom
(1) output winding (7) is tangent；Or the fixing device (5) can be embedded in and be located in the caliberating device (6)
The head model being made of soft material in housing (61) imitates body fixed body (51), and body fixed body (51) is imitated along the head model
The formation of central shaft up/down perforation has to install the through hole (52) that the head model imitates body (2), and the head model imitates body (2) peace
Mounted in described through hole (52) it is interior when, the head model is imitated body (2) and can be located in the through hole (52), and head model is imitated
The vertex of body (2) bottom and the output winding (7) of transcranial magnetic stimulation device (1) are tangent.
5. according to claim 1 be used to detect system of the transcranial magnetic stimulation in encephalic induction field, which is characterized in that
The output frequency of transcranial magnetic stimulation device (1) is under 3k~4kHz, and the head model imitates body (2) midbrain and imitates body (21), cerebrospinal fluid
Imitative body (22), skull imitate body (23) and scalp layer imitate body (24) electrical conductivity correspond to respectively 0.1~0.3S/m, 2~4S/m,
0.01~0.03S/m, 0.25~0.35S/m.
6. any one of a kind of claim 1-5 for detecting transcranial magnetic stimulation in the system of encephalic induction field
The head model production method of imitating body, which is characterized in that include the following steps：
1) respectively make scalp layer imitate body (24) and brain model (26), wherein, the scalp layer imitate body (24) thickness be 5~
8mm, the thickness of the brain model (26) is 70~80mm, is imitated including respectively in scalp layer opposite on body (24) and brain model (26)
First fixed column (10) of 2 or more is each provided at the position answered, wherein, scalp layer imitates the first fixed column on body (24)
(10) it is the setting that can dismantle；
2) the inner surface smearing skull layer that body (24) is imitated in the cortex made imitates body (23) thickness as 4~6.5mm；
3) brain model (26) is put into inner surface smears skull layer and imitate the scalp layer of body (23) and imitate on the inside of body (24), and make brain model
(26) the first fixed column (10) on imitated with scalp layer the first fixed column (10) on body (24) it is corresponding on, it is solid using first respectively
Scalp layer is imitated two the first fixed columns (10) corresponding on body (24) and brain model (26) and clamped by clamp (11), so that institute
The brain model (26) and the scalp layer stated imitate the gap that 3~6mm is formed between body (24)；
4) imitate injection cerebrospinal fluid in gap between body (24) in the brain model (26) and the scalp layer and imitate body material,
The processing of bubble is removed using ultrasonator, is then placed in refrigerator cold-storage；
5) cerebrospinal fluid, which is imitated to be formed with ditch after body material cooled and solidified and return the cerebrospinal fluid of structure, imitates body (22), removes scalp layer and imitates body
(24) the first geometrical clamp (11) and scalp layer and on brain model (26) imitate the first fixed column (10) on body (24), take out
Brain model (26) imitates injection brain in body (22) and imitates the material of body (21) obtaining head model and imitate body (2) in cerebrospinal fluid.
7. according to claim 6 imitate body for detecting head model of the transcranial magnetic stimulation in the system of encephalic induction field
Production method, which is characterized in that the brain model (26) described in step 1 is made using standard brain 3D printing, specifically
It is that 3 D stereo modeling is carried out to standard Typical AVM image using Mimics, generates STl documents, printed using 3D printer,
Its Plays brain using Montreal, CAN nerve MRI brain maps, the week in brain model (26) upper surface made
Side is uniformly installed by first fixed column (10) of 2 or more.
8. according to claim 6 imitate body for detecting head model of the transcranial magnetic stimulation in the system of encephalic induction field
Production method, which is characterized in that the scalp layer described in step 1 imitate body (24) be using scalp layer imitate mould make, institute
The scalp layer stated imitates mould and includes external mold (8) and internal model (9), and the external mold (8) is the semicircle that radius is 82~100mm
Housing, the internal model (9) is the hemisphere that radius is 77~95mm, in the upper surface of the external mold (8) and internal model (9) upper end
Second fixed column (12) of 2 or more is each provided at the corresponding position in periphery in face, internal model (9) is put into the interior of external mold (8)
Side, and make to be formed with the gap of 5~8mm between internal model (9) and external mold (8), and make the second fixed column (12) on external mold (8) with
In the second fixed column (12) correspondence in internal model (9), respectively using the second geometrical clamp (13) by institute on external mold (8) and internal model (9)
Corresponding two the second fixed columns (12) clamp, injection head in the gap between the external mold (8) and the internal model (9)
Cortex imitates body material, after scalp layer imitates body material solidification, removes the second geometrical clamp (13) on external mold (8) and internal model (9), takes out
The coagulum being formed between external mold (8) and internal model (9) is that scalp layer imitates body (24).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511035157.9A CN105572488B (en) | 2015-12-31 | 2015-12-31 | For detecting system and production method of the transcranial magnetic stimulation in encephalic induction field |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511035157.9A CN105572488B (en) | 2015-12-31 | 2015-12-31 | For detecting system and production method of the transcranial magnetic stimulation in encephalic induction field |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105572488A CN105572488A (en) | 2016-05-11 |
| CN105572488B true CN105572488B (en) | 2018-06-05 |
Family
ID=55882850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201511035157.9A Active CN105572488B (en) | 2015-12-31 | 2015-12-31 | For detecting system and production method of the transcranial magnetic stimulation in encephalic induction field |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105572488B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110491518B (en) * | 2019-07-31 | 2023-04-07 | 中国医学科学院生物医学工程研究所 | Transcranial magnetic stimulation modeling simulation method for task state |
| CN112704486B (en) | 2021-01-14 | 2021-10-26 | 中国科学院自动化研究所 | TMS coil pose map generation method based on electromagnetic simulation calculation |
| CN113724562B (en) * | 2021-07-20 | 2023-04-14 | 西安交通大学 | Simulated craniocerebral model for transcranial ultrasonic scanning and preparation method thereof |
| CN114073820B (en) * | 2022-01-20 | 2022-06-24 | 中国科学院自动化研究所 | Position and posture positioning device, method and equipment of transcranial magnetic stimulation coil for brain atlas navigation |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8052591B2 (en) * | 2006-05-05 | 2011-11-08 | The Board Of Trustees Of The Leland Stanford Junior University | Trajectory-based deep-brain stereotactic transcranial magnetic stimulation |
| US7753836B2 (en) * | 2006-06-15 | 2010-07-13 | The Trustees Of Columbia University In The City Of New York | Systems and methods for inducing electric field pulses in a body organ |
| CN201353206Y (en) * | 2009-02-24 | 2009-12-02 | 中国医学科学院生物医学工程研究所 | Phantom model used for cranial nerve magnetic stimulation induced electric field detection |
| CN104096316B (en) * | 2014-07-21 | 2015-11-18 | 中国医学科学院生物医学工程研究所 | A kind of H type coil optimization method for brain deep transcranial magnetic stimulation |
| CN104740780B (en) * | 2015-03-20 | 2017-04-19 | 中国科学院电工研究所 | Electromagnetic positioning and navigation device for transcranial magnetic stimulator |
-
2015
- 2015-12-31 CN CN201511035157.9A patent/CN105572488B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN105572488A (en) | 2016-05-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105572488B (en) | For detecting system and production method of the transcranial magnetic stimulation in encephalic induction field | |
| Hoekema et al. | Measurement of the conductivity of skull, temporarily removed during epilepsy surgery | |
| Jiang et al. | In vivo imaging of cancer cell size and cellularity using temporal diffusion spectroscopy | |
| Michel et al. | Electrical conductivity and permittivity maps of brain tissues derived from water content based on T1‐weighted acquisition | |
| Katscher et al. | Determination of electric conductivity and local SAR via B1 mapping | |
| Glover et al. | Measurement of electric fields induced in a human subject due to natural movements in static magnetic fields or exposure to alternating magnetic field gradients | |
| CN106377261A (en) | Body model for detecting quality of magnetic resonance function imaging and method | |
| Li et al. | A new head phantom with realistic shape and spatially varying skull resistivity distribution | |
| WO2008144421A1 (en) | Fast two-point mapping of the bound pool fraction and cross-relaxation rate constant for mri | |
| Wu et al. | A review of anisotropic conductivity models of brain white matter based on diffusion tensor imaging | |
| Sperandio et al. | A four-shell diffusion phantom of the head for electrical impedance tomography | |
| Jahng et al. | Low-frequency dominant electrical conductivity imaging of in vivo human brain using high-frequency conductivity at Larmor-frequency and spherical mean diffusivity without external injection current | |
| Shmueli et al. | Design, construction and evaluation of an anthropomorphic head phantom with realistic susceptibility artifacts | |
| Gamba et al. | Measurement of electrical current density distribution in a simple head phantom with magnetic resonance imaging | |
| CN110433396B (en) | Brain tissue electromagnetic field analysis method based on transcranial magnetic stimulation instrument | |
| Sadleir et al. | A controllably anisotropic conductivity or diffusion phantom constructed from isotropic layers | |
| Sekino et al. | Low‐frequency conductivity tensor of rat brain tissues inferred from diffusion MRI | |
| CN206434331U (en) | A kind of fMRI quality testing body mould | |
| Jeong et al. | Assessment of radio-frequency heating of a parallel transmit coil in a phantom using multi-echo proton resonance frequency shift thermometry | |
| CN220270511U (en) | Special equipment for detecting magnetic field and temperature of transcranial magnetic stimulation therapeutic apparatus | |
| Elsaid et al. | The impact of anisotropy on the accuracy of conductivity imaging: A quantitative validation study | |
| Mandija | Non-Invasive Characterization of Brain Tissue Electrical Properties with MRI | |
| Ma et al. | Validation of Computational Simulation for Tumor-treating Fields with Homogeneous Phantom | |
| Chauhan et al. | Phantom Construction and Equipment Configurations for Characterizing Electrical Properties Using MRI | |
| Kuratko et al. | Electromagnetic Modeling of Rat’s Head: Comparison of Formulations and Models |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20220214 Address after: 518107 18th floor, block B, high tech innovation center, guangqiao Road, Tianliao community, Yutang street, Guangming District, Shenzhen City, Guangdong Province Patentee after: SHENZHEN DELICA MEDICAL EQUIPMENT Co.,Ltd. Address before: 300192, 236 Bai Causeway Road, Tianjin, Nankai District Patentee before: CHINESE ACADEMY OF MEDICAL SCIENCES INSTITUTE OF BIOMEDICAL ENGINEERING |
|
| CP01 | Change in the name or title of a patent holder | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 518107 18th floor, block B, high tech innovation center, guangqiao Road, Tianliao community, Yutang street, Guangming District, Shenzhen City, Guangdong Province Patentee after: Shenzhen Delikai Medical Electronics Co.,Ltd. Address before: 518107 18th floor, block B, high tech innovation center, guangqiao Road, Tianliao community, Yutang street, Guangming District, Shenzhen City, Guangdong Province Patentee before: SHENZHEN DELICA MEDICAL EQUIPMENT Co.,Ltd. |