CN206434331U - A kind of fMRI quality testing body mould - Google Patents
A kind of fMRI quality testing body mould Download PDFInfo
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- CN206434331U CN206434331U CN201621077365.5U CN201621077365U CN206434331U CN 206434331 U CN206434331 U CN 206434331U CN 201621077365 U CN201621077365 U CN 201621077365U CN 206434331 U CN206434331 U CN 206434331U
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Abstract
The utility model discloses a kind of fMRI quality testing body mould, include being provided with BOLD noise signal modules, second shell body in the independent cases of two flexible connections, first shell body and be provided with basic image checking module；BOLD noise signal modules include positioning accuracy test suite and BOLD signal simulation components, the positioning accuracy test suite includes two and intersects the locating piece placed, the wedgy passage formed by isosceles right angle trigonometry block is provided with the locating piece, the BOLD signal simulations component includes the artificial brain for fMRI；The utility model being capable of simulated humanbody BOLD signal intensities, simulation magnetic resonance system midbrain active region, it is adaptable to accuracy, reliability and the repeatable test analysis research of cerebral function imaging.
Description
Technical field
The utility model is related to a kind of fMRI quality testing body mould, and BOLD is based in particular for magnetic resonance
The image quality detection body mould of the cerebral function imaging (task state) of (dependence of blood oxygenation level) signal, specifically a kind of emulation
Human body BOLD signal intensities, the imaging model of simulation magnetic resonance system midbrain active region, accuracy for cerebral function imaging, can
By property and repeatable test analysis research.
Background technology
Magnetic resonance cerebral function imaging is based on BOLD phenomenons, is typically scanned by fast imaging sequences, and Detection task state brain breaks
T of the face picture with ground state brain section image2* signal (actual T2Relaxation time) difference (task state functional MRI), pass through image
The brain domain of processing stimulation corresponding with determination after statistical analysis.Because BOLD signal existence times are extremely short (3-6ms), it is impossible to logical
Cross anatomy goldstandard checking brain domain.Therefore, the accuracy of cerebral function imaging and repeatability are relatively low always, brain function point
Analyse result and also there is dispute always.In this case, it is necessary to which a kind of emulate BOLD signals, and Functional MRI is coordinated
The examination criteria device of (imaging and data analysis), carries out the analysis result checking that imaging results calibration and brain domain, brain are connected.
Utility model content
The utility model is in order to solve the above problems, it is proposed that a kind of fMRI quality testing body mould, this reality
Had the characteristics that with new：1. there is brain mode of appearance, the morphology fidelity of magnetic resonance imaging is high；2. have by external
Current disturbing uniformity of magnetic field, forming region T2* BOLD emulation modules of signal intensity (enhancing)；3. there is resolution ratio, several
The basic magnetic resonance imaging detection module such as what distortion, signal to noise ratio, possesses detection versatility.4. mould is for external programmable power supply
Controller, can be in current switching, duration, pulse number of the outdoor remote control BOLD emulation modules of shielding etc..It is controlled
Scheme can combine the rapid serial of fMRI, set stimulation protocol.
To achieve these goals, the utility model is adopted the following technical scheme that：
A kind of fMRI quality testing body mould, is included in the independent case of two flexible connections, first shell body
It is provided with BOLD noise signal modules, second shell body and is provided with basic image checking module；
The BOLD noise signal modules include positioning accuracy test suite and BOLD signal simulation components, the positioning
Accuracy test suite includes being provided with two locating pieces for intersecting placement, the locating piece to be formed by isosceles right angle trigonometry block
Wedgy passage, the BOLD signal simulations component include for fMRI artificial brain；
The basic image checking module, including separate positioning accuracy test suite, geometry test group
Part, high-contrast component and layer deviation measurement assembly, the geometry test component are Multilayer grid structure, to emulate each side
To image geometric distortion degree；The high-contrast component includes substrate and the multiple rows of aperture set on substrate is different
Through hole；The layer deviation measurement assembly includes basic unit and be orthogonal two gaps set in basic unit.
It is preferred that, first housing and the second housing are the cylindrical shell of lucite, and two housings is straight
Footpath is identical, and the height of the first housing is more than the height of the second housing.
It is preferred that, first housing and the second hull outside are provided with bayonet socket, by the bayonet socket, and two housings connect
It is connected together.
It is preferred that, first housing and the second housing are filled with magnetic resonance standard test solution, such as copper sulphate, distillation
Water, sodium chloride or nickel chloride.
It is preferred that, the geometry test component, including Multilayer grid, the square hole dimension of each grid is identical, and side
The side thickness of lattice is identical, by scanning every layer, distance between any two grid summit is measured in acquired image, with actual distance
Compare, obtain the geometric distortion degree of axial direction image, by measuring distance between different interlayer grid summits, obtain sagittal and
The geometric distortion in coronal direction.
It is preferred that, the grid is PVC materials, and the number of plies is 3 layers.
It is preferred that, the through hole of multiple rows of different-diameter is provided with the substrate of the high-contrast component, and often row is also more
Individual through hole, the through-hole diameter of same row is identical, and the interval of same diameter through hole is equal to its diameter, by scanning, is being obtained
Image on observe through hole image, if the hole of same diameter is high-visible and signal is discrete, meet this condition most
Small-bore is the visual width of the limit.
It is preferred that, the wedge shape on the locating piece of the positioning accuracy test suite is laid in intersection, and two locating pieces
Long side infall be provided with position line, illustrate that positioning is accurate if the black strip blanking bar equal length formed in scan image
Really, otherwise there is deviation in positioning.
It is preferred that, the gap in 45 ° is provided with the basic unit of the layer deviation measurement assembly, two gaps are orthogonal, and gap
Width it is identical, the signal formed by two gaps on the image of scanning calculates and confirms actual thickness, obtains thickness setting partially
Difference.
It is preferred that, the setting regions in the second shell body is scanned, by the signal, noise and square margin that obtain the region
Value, calculates signal noise ratio (snr) of image.
It is preferred that, the artificial brain of the BOLD signal simulations component profile is copper sulphate containing 0.5%-1%, 0.3%-
0.5% sodium chloride, 1%-1.25% agaroses, 0.100%-0.125%Gd-DTPA (gadolinium diethylene triamine pentaacetic acid) water-setting
Glue, for emulating the ectocinereal T of magnetic resonance servant1And T2Relaxation value.
It is preferred that, the artificial brain has the construction profile that people's brain, cerebellum, the ventricles of the brain, ditch are returned.Artificial brain morphological data
From Montreal neurology research institute (Montreal neurological Institute) ICBM
(International Consortium for Brain Mapping), is a standard for combining 152 actual brains
Brain digital three-dimensional matrix, by 3D printing, obtains the appearance profile of the digital brain, is subsequently filled material stroke artificial brain in kind.
It is preferred that, frontal lobe position, the hippocampus position of the artificial brain correspond to the horizontal short-axis direction difference of the first housing
A cavity is provided with, 1cm, 5cm is returned apart from surface ditch respectively, frontal lobe, hippocampus (hippocampus and amygdaloid nucleus tool for emulating human brain
Have relatively low bold signals) the BOLD signals in region, human simulation brain cognitive function region.The cingulate gyrus position of artificial brain corresponds to
Longitudinal long axis direction of first housing is respectively arranged with a cavity, and 3cm, the cingulum for emulating human brain are returned apart from surface ditch
The BOLD signals returned.
It is preferred that, the first housing is extended in longitudinal axis direction of the coil along the first housing, is connected by connecting line
External power source controller.
It is preferred that, the external power source controller is programmable controller, controls the connection of power supply and each coil, continues
Or shut-off, while controlling ON/OFF time, duration, frequency and number of times.
Based on the detection method of above-mentioned detection body mould, including：
During conventional sweep artificial brain component, three coils are in the hydrone in off state, cavity, the water in gel
Molecule is in normal magnetic resonance signal imaging；
When task state is scanned, external power source controller coordinates scanning sequence, according to setting pulse frequency, turns on and off,
Corresponding cavity interior loop is set to produce pulse current, the local magnetic field that pulse current is changed in cavity residing for hydrone is uniform
Property, cause the time to change；
The signal difference of conventional sweep and the scanning of task state is alternately lasting to be occurred, and emulation human brain BOLD signals is realized, to obtaining
The brain function magnetic resonance sequences image obtained carries out brain contours extract.
The beneficial effects of the utility model are：
(1) the utility model provides a kind of simulated humanbody BOLD signal intensities, simulation magnetic resonance system midbrain active region
Imaging model, for the accuracy of cerebral function imaging, reliability and the research of repeatable test analysis；
(2) the utility model can coordinate the examination criteria device of Functional MRI (imaging and data analysis), enter
The analysis result checking that row imaging results are calibrated and brain domain, brain are connected；
(3) the utility model has a brain mode of appearance, and the morphology fidelity of magnetic resonance imaging is high, with passing through external electricity
Flow disturbance uniformity of magnetic field, being capable of forming region T2* signal intensity；
(4) the utility model has the basic magnetic resonance imaging detection module such as resolution ratio, geometric distortion, signal to noise ratio, possesses
Detect versatility；
(5) the utility model can be in the current switching of the outdoor remote control BOLD emulation modules of shielding, duration, pulse
Number of times etc., be effectively guaranteed emulation experiment person it is healthy with it is safe.
Brief description of the drawings
Fig. 1 is body mould entire combination outside drawing of the present utility model；
Fig. 2 is geometry test component diagram of the present utility model；
Fig. 3 is high-contrast test suite schematic diagram of the present utility model；
Fig. 4 (a) is layer deviation measurement assembly side view of the present utility model；
Fig. 4 (b) is layer deviation measurement assembly front view of the present utility model；
Fig. 5 is the coil shape schematic diagram in artificial brain rectangular space of the present utility model；
Fig. 6 is the connection of body mould of the present utility model and external power source controller and uses position view.
Embodiment：
The utility model is described in further detail with embodiment below in conjunction with the accompanying drawings.
As shown in figure 1, a kind of quality control inspection suitable for medical magnetic resonance cerebral function imaging, emulation BOLD signal intensities
Body mould is surveyed, including overall structure, BOLD noise signal modules and the basic image checking module of dismounting can be combined.
The PMMA plexiglass cylinder shape shells that dismounting profile module includes diameter 18CM can be combined, shell is divided into 15CM
Two high high, 5CM parts.Dismounting, internal mutual not UNICOM can be combined in two parts.The high cylinders of 15CM include BOLD emulation signal modes
Block, one end closing, one end passes through wire UNICOM external power source controller.5CM is high, and cylinder is closed at both ends, and including to be differentiated
Magnetic resonance standard test solution (sulfuric acid is filled in the module of the basic imaging parameters detection such as rate, geometric distortion, signal to noise ratio, cylinder
Copper, distilled water, sodium chloride/nickel chloride).Two cylinders can be combined by bayonet socket.
BOLD noise signal modules and basic image checking module two ends include the square joinery and its construction of PMMA materials, pass through
The link of joinery and its construction, opening, realize the connection and separation of two modules of body mould.Make two modules of body mould to merge use (to sweep
Retouch), also can independently it use.
Basic image checking module, inside includes five independent test components.Respectively：
1. the geometry test component being made up of rectangle grid matrix, component is 3 layers of PVC material grids.Grid it is every
Individual square hole ties up 3 × 3 × 3mm3, the PVC sides thickness 1mm of grid block.By scanning the layer, any two is measured in acquired image
Distance between grid summit, is compared with actual distance, can obtain the geometric distortion degree of axial direction image.Grid be divided into above and below 3
Layer, interlayer PVC thickness 1mm, by measuring distance between different interlayer grid summits, can obtain the geometry in sagittal and coronal direction
Distortion.As shown in Figure 2.
2. high-contrast (limiting resolution) component being made up of different-diameter through hole, on PMMA substrates containing 5 rows not
With the through hole of diameter, aperture is 5mm, 2.5mm, 1mm, 0.5mm, 0.2mm, and the interval of same diameter through hole is equal to its diameter.
As shown in Figure 3.By scanning the layer, on the image obtained observe through hole image, the hole of such as same diameter it is high-visible and
Signal is discrete, then the minimum-value aperture for meeting this condition is the visual width of the limit.
3. the positioning accuracy test suite being made up of wedge-shaped isosceles right angle trigonometry block, two isosceles right triangles, which intersect, to be put
Put.As shown in Figure 4.When scanning this layer, position line is placed on the long side infall of two corner blocks.Such as accurate positioning, then in image
The black strip blanking bar equal length that corner block is formed.As there is deviation in alignment system, then two black strip Length discrepancy.
4. layer deviation measurement assembly is constituted by the strip PVC containing seam, PVC rectangle block lengths 6mm, wide 6mm contain 2 45
The wide seams of 1mm are spent, two seams are orthogonal.The layer is scanned, then occurs that two symmetrical bright signals (are saturated with test in seam on image
Caused by liquid), the halfwidth of bright signal is measured, the product and evolution of two halfwidths is calculated, obtains actual thickness, compared with setting thickness
Compared with, can obtain thickness setting deviation.
5. without overflow layer assembly in kind, for measuring signal to noise ratio.When scanning this layer, gained image can be used for selection sense emerging
Interesting area, by obtaining signal, noise and variance value, computable signal noise ratio (snr) of image.
BOLD noise signal modules include positioning accuracy test suite and BOLD signal simulation components.Positioning accuracy is surveyed
Try modular construction consistent with basic image checking module.
BOLD signal simulation components profile is 15 × 15 × 13cm3Artificial brain.Artificial brain be 0.5%-1% copper sulphate,
0.3%-0.5% sodium chloride, 1%-1.25% agaroses, 0.100%-0.125%Gd-DTPA (gadolinium diethylene triamine pentaacetic acid)
Hydrogel, the ectocinereal T of magnetic resonance servant can be emulated1And T2Relaxation value.
Its mode of appearance is emulated by " Chinese Digital Human " standard brain image and obtained, and registration ICBM standard brains.Possesses emulation
The construction profile that people's brain, cerebellum, the ventricles of the brain, ditch are returned.Hydrogel contains abundant Hydrogen Proton, can produce class in magnetic resonance imaging
Like the high RST of human brain brightness.
Containing rectangle volume space three small inside artificial brain, space about 3375mm3(account for 125 27mm3Function
Magnetic resonance imaging voxel, 3-4 scanning aspect).Contain straight footpath≤2mm circular coil in space, coil is sub-thread, rubber bag
Wrap up in, space is entered by body mould long axis direction, after 350 degree, space is passed by long axis direction.As shown in Figure 5.Coil is in space
Magnetic resonance standard test liquid (pure water, copper sulphate and sodium chloride) is filled in interior fixation, space.
Two rectangle volume spaces are located at body mould short-axis direction, frontal lobe respectively positioned at artificial brain, hippocampus position, difference
1cm, 5cm, frontal lobe, hippocampus (hippocampus and amygdaloid nucleus have relatively low bold signals) area for emulating human brain are returned apart from surface ditch
The BOLD signals in domain, human simulation brain cognitive function region.One rectangle volume space is located at body mould long axis direction, positioned at emulation
The cingulate gyrus position of brain, 3cm, the BOLD signals of the cingulate gyrus for emulating human brain are returned apart from surface ditch.
Winding wiring two ends in three rectangle volume spaces pass body mould, wiring connection external power source controller.Connect
Line length >=5M, it is ensured that when body mould is in scanning mode, external power source controller can be placed on peripheral operation room by waveguide plate
Console.As shown in Figure 6.
External power source controller is programmable controller, and the connection of power supply is set by programming, continues, turn off；Connection/pass
Disconnected time, duration, frequency and number of times.
BOLD emulation modules can be used for fMRI.During conventional sweep artificial brain component, three coils are in
Off state.The hydrone in hydrone, gel in rectangle volume space is in normal magnetic resonance signal imaging.Appoint
During state of being engaged in scanning, external power source controller coordinates scanning sequence, according to setting pulse frequency, turns on and off, and makes production in coil
Raw pulse current.Pulse current (duration≤6ms) changes the local magnetic field residing for hydrone in rectangle volume space
Uniformity, causes T2*Time changes, with conventional sweep T2*There is 1-3% signal difference.What conventional sweep and task state were scanned
Signal difference is alternately lasting to be occurred, the duration >=6Min.So as to realize the function of emulation human brain BOLD signals.
External power source controller includes fiber optic receiver, frequency-voltage converter and current driver, remote control line
Circle.External power source controller by programming, can be achieved three volume space interior loops while and independent ON/OFF (>=
200/S), high/low currents switching (1mA Huo≤0.5mA), the BOLD signal simulations in emulation one or more functions area；Also it can realize
The independent ON/OFF of order (interval time≤6ms) of three volume space interior loops, high/low currents switching, for different work(
The brain linking parsing emulation in energy area.
The subsidiary image post processing software of body mould.Software is mountable to Windows series platforms and Linux platform, and software is used
Enter row format in the brain function magnetic resonance sequences image (.img/.dcm forms) obtained to various producer's magnetic resonance systems constant
Brain contours extract." head clearing " operation i.e. in functional MRI processing procedure, while automatic by external power source control
The excitation sequence data of device import conventional MRI image processing software (SPM, AFNI, FSL etc.).
It is not new to this practicality although above-mentioned embodiment of the present utility model is described with reference to accompanying drawing
The limitation of type protection domain, one of ordinary skill in the art should be understood that on the basis of the technical solution of the utility model, ability
Field technique personnel need not pay the various modifications that creative work can make or deform still in protection model of the present utility model
Within enclosing.
Claims (10)
1. a kind of fMRI quality testing body mould, it is characterized in that：Include the independent case of two flexible connections, first
It is provided with housing in BOLD noise signal modules, second shell body and is provided with basic image checking module；
The BOLD noise signal modules include positioning accuracy test suite and BOLD signal simulation components, the accurate positioning
Property test suite include two and intersect the locating pieces placed, be provided with the wedge formed by isosceles right angle trigonometry block on the locating piece
Shape passage, the BOLD signal simulations component includes the artificial brain for fMRI；
The basic image checking module, including separate positioning accuracy test suite, geometry test component, height
Contrast component and layer deviation measurement assembly, the geometry test component are Multilayer grid structure, to emulate all directions
The geometric distortion degree of image；The high-contrast component includes different logical of substrate and multiple rows of aperture for being set on substrate
Hole；The layer deviation measurement assembly includes basic unit and be orthogonal two gaps set in basic unit.
2. a kind of fMRI quality testing body mould as claimed in claim 1, it is characterized in that：First housing and
Second housing is the cylindrical shell of lucite, and the diameter of two housings is identical, and the height of the first housing is more than second
The height of housing.
3. a kind of fMRI quality testing body mould as claimed in claim 1, it is characterized in that：
The geometry test component, including Multilayer grid, the square hole dimension of each grid are identical, and the side thickness phase of grid
Together, by scanning every layer, distance between any two grid summit is measured in acquired image, is compared with actual distance, obtain axle
To the geometric distortion degree of directional image, by measuring distance between different interlayer grid summits, sagittal and coronal direction are obtained
Geometric distortion.
4. a kind of fMRI quality testing body mould as claimed in claim 1, it is characterized in that：The high-contrast group
The through hole of multiple rows of different-diameter is provided with the substrate of part, and often row also has multiple through holes, the through-hole diameter of same row is identical, phase
Interval with diameter through hole is equal to its diameter, by scanning, through hole image is observed on the image obtained, if same diameter
Hole it is high-visible and signal is discrete, then the minimum-value aperture for meeting this condition is the visual width of the limit.
5. a kind of fMRI quality testing body mould as claimed in claim 1, it is characterized in that：The positioning accuracy
Wedge shape on the locating piece of test suite is laid in intersection, and the long side infall of two locating pieces is provided with position line, if sweeping
Black strip blanking bar equal length of the tracing as formed in then illustrates accurate positioning, and otherwise positioning has deviation.
6. a kind of fMRI quality testing body mould as claimed in claim 1, it is characterized in that：The layer deviation measurement
The gap in 45 ° is provided with the basic unit of component, two gaps are orthogonal, and the width in gap is identical, passes through on the image of scanning two
The signal that bar gap is formed, calculates and confirms actual thickness, obtains thickness setting deviation.
7. a kind of fMRI quality testing body mould as claimed in claim 1, it is characterized in that：The BOLD signals are imitated
The artificial brain of true component profile be copper sulphate containing 0.5%-1%, 0.3%-0.5% sodium chloride, 1%-1.25% agaroses,
0.100%-0.125%Gd-DTPA hydrogel, for emulating the ectocinereal T of magnetic resonance servant1And T2Relaxation value.
8. a kind of fMRI quality testing body mould as claimed in claim 7, it is characterized in that：The artificial brain has
The construction profile that people's brain, cerebellum, the ventricles of the brain, ditch are returned.
9. a kind of fMRI quality testing body mould as claimed in claim 1, it is characterized in that：The volume of the artificial brain
The horizontal short-axis direction that leaf site, hippocampus position correspond to the first housing is respectively arranged with a cavity, the cingulate gyrus of artificial brain
Position is respectively arranged with a cavity, each cavity corresponding to longitudinal long axis direction of the first housing and is provided with coil.
10. a kind of fMRI quality testing body mould as claimed in claim 9, it is characterized in that：The coil is along
The first housing is extended in the longitudinal axis direction of one housing, and external power source controller is connected by connecting line.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106377261A (en) * | 2016-09-23 | 2017-02-08 | 泰山医学院 | Body model for detecting quality of magnetic resonance function imaging and method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106377261A (en) * | 2016-09-23 | 2017-02-08 | 泰山医学院 | Body model for detecting quality of magnetic resonance function imaging and method |
| CN106377261B (en) * | 2016-09-23 | 2023-12-26 | 泰山医学院 | Magnetic resonance functional imaging quality detection phantom and method |
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