CN201353206Y - Phantom model used for cranial nerve magnetic stimulation induced electric field detection - Google Patents

Abstract

The utility model discloses a phantom model used for cranial nerve magnetic stimulation induced electric field detection, which comprises a spherical structure provided with an opening. The spherical structure comprises a scalp phantom layer arranged outside and a skull phantom layer arranged in the scalp phantom layer, wherein a glue layer having same parameters with the scalp layer is filled between the scalp phantom layer and the skull phantom layer, cerebral cortex tissue phantom solution is filled in the skull phantom layer, and conductivity and relative dielectric constant of the scalp phantom layer, the skull phantom layer and the cerebral cortex tissue phantom solution approach to real human tissues within a range of magnetic stimulation frequency band of 1 to 10 kHz. The construction and the parameters are customized according to physiological structure design of a real human head, therefore, the model utilized to carry out a cranial nerve magnetic stimulation relative experiment enhances the simulation experiment accuracy, can more approach to a real human head structure on the boundary conditions so as to obtain better experiment accuracy in experiment measurement and research, and has higher research value on medical research.

Description

Be used for the imitative phantom type that nerve magnetic boost inductor electric field detects

Technical field

This utility model relates to clinical medicine cranial nerve stimulation therapy technical field, particularly a kind of imitative phantom type that is used for the detection of nerve magnetic boost inductor electric field.

Background technology

Transcranial magnetic stimulation (TMS) is the nearly 20 years a kind of new stimulating technologies that grow up, because stimulating, magnetic has noinvasive, easy and simple to handle, have advantages such as electric safety is good than electrical stimulation technology, in fields such as nerve, spirit, psychology, especially depression, obsession, Parkinson's disease, the treatment aspect of epilepsy and posttraumatic stress disorder etc., have good application prospects, become the focus of Recent study.

The transcranial magnetic stimulation device has mainly comprised capacitor and discharge coil that transmits energy of a store charge, its basic functional principle is, utilize the capacitor stores electric charge, when the electric charge in the capacitor discharged rapidly, electric current was by stimulating coil, and the magnetic field of generation forms induction field in brain, when faradic current intensity reaches certain threshold value by certain orientation, can make the neurocyte depolarization, produce and bring out current potential, reach the purpose of treatment or detection nerve conduction.

From the above mentioned, stimulating the faradic current that forms in the cerebral cortex specific region by magnetic, is to change the cerebral cortex irritability, carries out the key factor of nerve magnetic stimulation therapy, and the distribution of induction field is the important research content of nerve magnetic stimulating technology.The at present domestic research that stimulation is carried out about nerve magnetic mostly is the theoretical simulation research on basis, stimulate the experimentation of cortex induced potential for nerve magnetic, need detecting electrode implant into body head inside owing to measure, will damage human body, and be difficult to realize by the non-invasive methods detection, therefore stimulate the related experiment such as direct detection of cerebral cortex electric potential signal for nerve magnetic, need be undertaken by imitative phantom type.The imitative phantom type structure of using is simple relatively at present, semo-infinite boundary condition as single medium, use saline slot as measurements that experimentize of electromagnetic wave propagation medium, or adopt simple spherical container to put into a certain amount of normal saline, the spherical boundary condition of simulating monolayer experimentizes.Yet, the organizational structure of real human body head is comparatively complicated, and each layer tissue has different electric conductance, dielectric parameter, uses above-mentioned model to carry out the research of magnetic stimulation test, lower to the corticocerebral simulation precision of real human body, experimental result is bigger with true human brain results of stimulation error.

The utility model content

This utility model provides a kind of imitative phantom type that nerve magnetic boost inductor electric field detects that is used for for solving the technical problem that exists in the known technology, should approach the human body boundary condition more by imitative phantom type, simulate the precision height of true human brain, carry out the research of magnetic stimulation test with it, ratio error is little mutually with true human brain results of stimulation for experimental result.

The technical scheme that this utility model is taked for the technical problem that exists in the solution known technology is: a kind of imitative phantom type that is used for the detection of nerve magnetic boost inductor electric field, comprise the sphere structure that is provided with opening, described sphere structure comprises the imitative body layer of the scalp of outside, be positioned at the imitative body layer of skull of the imitative body layer of scalp the inside, in the imitative body layer of skull, be filled with the imitative liquid solution of brain cortical tissue, be filled with the glue layer identical between imitative body layer of described scalp and the imitative body layer of skull with the scalp electrical quantity, described scalp is imitated the body layer, skull is imitated the body layer, the electrical conductivity and the relative dielectric constant of the imitative liquid solution of brain cortical tissue, in magnetic stimulated frequency range 1-10kHz scope, the electrical conductivity of the imitative body layer of described scalp was 6.5 * 10 ^-4-3.0 * 10 ^-3S/m, relative dielectric constant are 2.9 * 10 ⁴-3.2 * 10 ⁴, the electrical conductivity of the imitative body layer of described skull is 2.0 * 10 ^-2-2.1 * 10 ^-2S/m, relative dielectric constant are 5.2 * 10 ²-2.7 * 10 ³, the electrical conductivity 9.9 * 10 of the imitative liquid solution of described brain cortical tissue ^-2-1.2 * 10 ^-1S/m, relative dielectric constant are 2.2 * 10 ⁴-1.6 * 10 ⁵

Should also be provided with adjustable fixture by imitative phantom type, described fixture comprises and the imitative affixed crossbeam of body layer of scalp that described crossbeam links to each other with column by contiguous block, is connected with base below the described column; Described contiguous block is provided with lateral aperture that is connected with crossbeam and the upright opening that is connected with column, and described lateral aperture is provided with the bolt that is used to compress crossbeam, and described upright opening is provided with the bolt that is used to compress column.

Described fixture adopts glass fiber material to make.

Advantage and the good effect that the utlity model has are: because model construction and parameter are according to real human body head physiological structure design customization, therefore utilizing this model to carry out nerve magnetic stimulates related experiment to improve the simulation experiment precision, saline slot experimental model and simple monolayer spherical model than the semo-infinite boundary condition, this model can more approach real human body head structure on boundary condition, thereby in experiment measuring and research, obtain better experimental precision, have higher researching value for medical research; This model is made by not perishable materials processing, so model is suitable for permanent preservation and use repeatedly; This model has measurement of correlation opening and fixing adjusting device, and the model adjustable height is convenient to carry out the experiment measuring of magnetic stimulating coil diverse location.

Description of drawings

Fig. 1 is a structural representation of the present utility model;

Fig. 2 is the vertical view of Fig. 1;

Fig. 3 is the structural representation of this utility model contiguous block.

Among the figure: 1, the imitative body layer of scalp, 2, the imitative body layer of skull, 3, the imitative liquid solution of brain cortical tissue, 4, glue layer, 5, measure opening, 6, contiguous block, 6-1, lateral aperture, 6-2, upright opening, 7, crossbeam, 8, column, 9, base, 10,11, bolt.

The specific embodiment

For further understanding summary of the invention of the present utility model, characteristics and effect, exemplify following examples now, and conjunction with figs. is described in detail as follows:

See also Fig. 1, Fig. 2 and Fig. 3, this utility model stimulates principle based on nerve magnetic, magnetic is stimulated the discharge current signal, utilize simulation software to after passing tissue such as scalp skull, simulate at the induction field signal that cortex forms in magnetic field, by each frequency content situation in the fourier transform analysis signal spectrum, determines each layer tissue parameter situation of head, and then select corresponding parameter material, imitate system and do.

Consider to be used for the magnetic stimulator discharge current signal that nerve magnetic stimulates,

$i\left(t\right)=\mathrm{CU}\sqrt{\frac{1}{\mathrm{LC}}-\frac{{\mathrm{<figure-callout\; id="2"\; label="R"\; filenames="Y2009200956400009H1.png"\; state="\{\{state\}\}">R</figure-callout>}}^2}{4{\mathrm{<figure-callout\; id="2"\; label="L"\; filenames="Y2009200956400009H1.png"\; state="\{\{state\}\}">L</figure-callout>}}^2}}\&CenterDot;e^{-\frac{R}{2L}t}\&CenterDot;[{\left(\frac{\frac{R}{2\mathrm{<figure-callout\; id="1"\; label="L"\; filenames="Y2009200956400009H1.png,Y2009200956400009H2.png"\; state="\{\{state\}\}">L</figure-callout>}}}{\sqrt{\frac{1}{\mathrm{LC}}-\frac{R^2}{4L^2}}}\right)}^2+1]\&CenterDot;\sin (\sqrt{\frac{1}{\mathrm{LC}}-\frac{R^2}{4{\mathrm{<figure-callout\; id="2"\; label="L"\; filenames="Y2009200956400009H1.png"\; state="\{\{state\}\}">L</figure-callout>}}^2}}\&CenterDot;t)$

Wherein, C is an electric capacity, and U is a charging voltage, and L is an inductance, and R is a resistance, and t is the time.

Obtain corticocerebral induction field signal by computer simulation,, need carry out Fourier transform, to analyze in the nerve magnetic stimulation main frequency content owing to form by a plurality of frequency contents in the induction field signal.The Fourier transform formula is as follows:

$G\left(e^{\mathrm{i\&theta;}}\right)=\underset{t=0}{\overset{T}{\mathrm{\&Sigma;}}}{C}_n(\mathrm{<figure-callout\; id="2"\; label="cos"\; filenames="Y2009200956400009H1.png"\; state="\{\{state\}\}">cos</figure-callout>}\frac{2\mathrm{\&pi;}}{T}\&CenterDot;{\mathrm{\&omega;}}_0\&CenterDot;n\&CenterDot;\mathrm{dt}-j\&CenterDot;\sin \frac{2\mathrm{\&pi;}}{T}\&CenterDot;{\mathrm{\&omega;}}_0\&CenterDot;n\&CenterDot;\mathrm{dt})$

C wherein _nBe the induction field signal, G (e ^{I θ}) be the induction field Fourier transform, ω ₀Be frequency, T is the cycle, and n is a signal Fourier transform sequence number.

Thereby obtain the frequency spectrum of induction field, can determine that through spectrum analysis frequency content main in the discharge waveform is 1-10kHz, and with this main foundation of choosing as the imitative phantom type frequency characteristic parameter of magnetic boost inductor electric field test experience.

According to above analysis, in conjunction with relevant medical measurement data, human body is each layer tissue parameter such as table 1 in the 1-10kHz scope.

On the other hand, because the contact of human body head tissue closely, and when having the air gap between the imitative body of model each several part tissue, can produce than mistake, so the imitative body material require of each layer tissue of model closely contacts experimental result.The present invention adopts solid and liquid structure combining to realize, model is divided into following a few part: scalp is imitated body layer 1, and skull is imitated body layer 2, and brain cortical tissue imitates liquid solution 3, model is provided with measures opening 5, and the experiment detection probe can stretch into from measurement opening 5 and measure.

Wherein the substrate of the material of the imitative body layer 1 of scalp is fluid silicone rubber, adds the SnO of 5%-10% (mass ratio, down together) yttrium aluminate and 0.05%-0.3% ₂High-temperature mixing is gone into the mould sulfuration and is made the imitative body layer of scalp; The example of the imitative body layer of several scalps below is provided:

Example 1: substrate is fluid silicone rubber, the yttrium aluminate of adding 5% and 0.3% SnO ₂High-temperature mixing is gone into the mould sulfuration and is made the imitative body layer of scalp.In magnetic stimulated frequency range 1-10kHz scope, after tested, calculate, electrical conductivity was 2.7 * 10 ^-3-3.0 * 10 ^-3S/m, relative dielectric constant are 2.9 * 10 ⁴-2.93 * 10 ⁴

Example 2: substrate is fluid silicone rubber, the yttrium aluminate of adding 7.5% and 0.2% SnO ₂High-temperature mixing is gone into the mould sulfuration and is made the imitative body layer of scalp.In magnetic stimulated frequency range 1-10kHz scope, after tested, calculate, electrical conductivity was 2.0 * 10 ^-3-2.3 * 10 ^-3S/m, relative dielectric constant are 3.0 * 10 ⁴-3.03 * 10 ⁴

Example 3: substrate is fluid silicone rubber, the yttrium aluminate of adding 10% and 0.05% SnO ₂High-temperature mixing is gone into the mould sulfuration and is made the imitative body layer of scalp.In magnetic stimulated frequency range 1-10kHz scope, after tested, calculate, electrical conductivity was 6.5 * 10 ^-4-8.0 * 10 ^-4S/m, relative dielectric constant are 3.16 * 10 ⁴-3.2 * 10 ⁴

The imitative body layer 2 of skull can be added the acetylene black mixing of 2%-6.5% by Barium metatitanate., can be made into behind the sintering.The example of the imitative body layer of several skulls below is provided:

Example 1: substrate adopts Barium metatitanate., adds 2% acetylene black mixing, makes the imitative body layer of skull behind the sintering.In magnetic stimulated frequency range 1-10kHz scope, after tested, calculate, electrical conductivity was 2.00 * 10 ^-2-2.02 * 10 ^-2S/m, relative dielectric constant are 5.2 * 10 ²-8.7 * 10 ²

Example 2: substrate adopts Barium metatitanate., adds 4% acetylene black mixing, makes the imitative body layer of skull behind the sintering.In magnetic stimulated frequency range 1-10kHz scope, after tested, calculate, electrical conductivity was 2.04 * 10 ^-2-2.06 * 10 ^-2S/m, relative dielectric constant are 1.32 * 10 ³-1.6 * 10 ³

Example 3: substrate adopts Barium metatitanate., adds 6.5% acetylene black mixing, makes the imitative body layer of skull behind the sintering.In magnetic stimulated frequency range 1-10kHz scope, after tested, calculate, electrical conductivity was 2.08 * 10 ^-2-2.1 * 10 ^-2S/m, relative dielectric constant are 2.5 * 10 ³-2.7 * 10 ³

Fill and the imitative identical colloid layer 4 of body layer 1 electrical quantity of scalp between imitative body layer 1 of scalp and the imitative body layer 2 of skull, with the deaeration gap; The imitative body layer 2 inner imitative liquid solution 3 of the brain cortical tissue of being made by sugar juice and potassium chloride powder mixes of filling of skull, imitative liquid solution 3 can be added the potassium chloride powder mixes of 0.01%-0.02% by the sugar juice of 40%-45% and make.The example of the imitative body layer of several skulls below is provided:

The sugar juice of example 1:40% adds the imitative liquid solution of brain cortical tissue that 0.02% potassium chloride powder mixes is made, in magnetic stimulates frequency range 1-10kHz scope, after tested, calculate electrical conductivity 1.1 * 10 ^-1-1.2 * 10 ^-1S/m, relative dielectric constant are 2.2 * 10 ⁴-2.6 * 10 ⁴

The sugar juice of example 2:45% adds the imitative liquid solution of brain cortical tissue that 0.01% potassium chloride powder mixes is made, in magnetic stimulates frequency range 1-10kHz scope, after tested, calculate electrical conductivity 9.9 * 10 ^-2-1.0 * 10 ^-1S/m, relative dielectric constant are 1.2 * 10 ⁵-1.6 * 10 ⁵

Wherein the substrate of colloid layer 4 materials is that concentration is the agar of 0.15%-0.3%, after the heating, adds the SnO of 0.1%-0.3% ₂Mixing, colloid is made in cooling, and above-mentioned colloid is coated in the scalp layer, puts into ready made skull layer then, compacting.The example of several colloid layers below is provided:

Example 1: concentration is 0.15% agar, heating, and add 0.3% SnO ₂Mixing is gone into the mould cooling and is made colloid layer.In magnetic stimulated frequency range 1-10kHz scope, after tested, calculate, electrical conductivity was 2.25 * 10 ^-3-3.0 * 10 ^-3S/m, relative dielectric constant are 2.91 * 10 ⁴-2.94 * 10 ⁴

Example 2: concentration is 0.2% agar, heating, and add 0.2% SnO ₂Mixing is gone into the mould cooling and is made colloid layer.In magnetic stimulated frequency range 1-10kHz scope, after tested, calculate, electrical conductivity was 2.2 * 10 ^-3-2.4 * 10 ^-3S/m, relative dielectric constant are 2.97 * 10 ⁴-3.0 * 10 ⁴

Example 3: concentration is 0.3% agar, heating, and add 0.1% SnO ₂Mixing is gone into the mould cooling and is made colloid layer.In magnetic stimulated frequency range 1-10kHz scope, after tested, calculate, electrical conductivity was 6.8 * 10 ^-4-8.5 * 10 ^-4S/m, relative dielectric constant are 3.14 * 10 ⁴-3.18 * 10 ⁴

In addition, for the ease of fixing of experiment measuring and model, this utility model is provided with adjustable fixture, fixture adopts glass fiber material to make, comprise and the imitative affixed crossbeam 7 of body layer of scalp that crossbeam 7 links to each other with column 8 by contiguous block 6, be connected with base 9 below the column 8; Contiguous block 6 is provided with lateral aperture 6-1 that is connected with crossbeam 7 and the upright opening 6-2 that is connected with column, and lateral aperture 6-1 is provided with the bolt 10 that is used to compress crossbeam 7, and upright opening 6-2 is provided with the bolt 11 that is used to compress column 8.Adjust the height of crossbeam 7 and model by unclamping bolt 11, the position of crossbeam 7 and model tights a bolt 11 after determining, model is fixed.Get final product the adjustable height of implementation model, to reach the adjustable purpose of distance of the imitative phantom type of magnetic stimulating coil and human body head.

The experimental model that uses this utility model to relate to carries out the nerve magnetic stimulation test, will imitate the phantom type and be inverted and be placed on fixedly on the adjusting device, and probe is fixed on the three-dimensional fix device, and it is deep vertically downward from measuring opening, measures after the adjustment.Because at probe two electrode distances hour, voltage is approximated to direct ratio between induction field intensity and probe electrode,

V＝E·d

Wherein, V is a voltage between probe electrode, and E is an electric field intensity, and d is the measuring probe interelectrode distance.

Therefore only after needing measuring probe two inter-electrode voltages are handled by amplification filtering etc., can try to achieve induction field intensity, utilize positioner mobile probe to other positions to measure again, can finally realize the measurement that induction field distributes.

Although in conjunction with the accompanying drawings preferred embodiment of the present utility model is described above; but this utility model is not limited to the above-mentioned specific embodiment; the above-mentioned specific embodiment only is schematic; be not restrictive; those of ordinary skill in the art is under enlightenment of the present utility model; not breaking away under the scope situation that this utility model aim and claim protects, can also make a lot of forms, these all belong within the protection domain of the present utility model.

Claims (3)

1. one kind is used for the imitative phantom type that nerve magnetic boost inductor electric field detects, comprise the sphere structure that is provided with opening, it is characterized in that, described sphere structure comprises the imitative body layer of the scalp of outside, be positioned at the imitative body layer of skull of the imitative body layer of scalp the inside, in the imitative body layer of skull, be filled with the imitative liquid solution of brain cortical tissue, be filled with and the identical glue layer of scalp layer electrical quantity between imitative body layer of described scalp and the imitative body layer of skull, described scalp is imitated the body layer, skull is imitated the body layer, the electrical conductivity and the relative dielectric constant of the imitative liquid solution of brain cortical tissue, in magnetic stimulated frequency range 1-10kHz scope, the electrical conductivity of the imitative body layer of described scalp was 6.5 * 10 ^-4-3.0 * 10 ^-3S/m, relative dielectric constant are 2.9 * 10 ⁴-3.2 * 10 ⁴, the electrical conductivity of the imitative body layer of described skull is 2.0 * 10 ^-2-2.1 * 10 ^-2S/m, relative dielectric constant are 5.2 * 10 ²-2.7 * 10 ³, the electrical conductivity 9.9 * 10 of the imitative liquid solution of described brain cortical tissue ^-2-1.2 * 10 ^-1S/m, relative dielectric constant are 2.2 * 10 ⁴-1.6 * 10 ⁵

2. the imitative phantom type that is used for the detection of nerve magnetic boost inductor electric field according to claim 1, it is characterized in that: this imitative phantom type also is provided with adjustable fixture, described fixture comprises and the imitative affixed crossbeam of body layer of scalp, described crossbeam links to each other with column by contiguous block, is connected with base below the described column; Described contiguous block is provided with lateral aperture that is connected with crossbeam and the upright opening that is connected with column, and described lateral aperture is provided with the bolt that is used to compress crossbeam, and described upright opening is provided with the bolt that is used to compress column.

3. the imitative phantom type that is used for the detection of nerve magnetic boost inductor electric field according to claim 2 is characterized in that: described fixture adopts glass fiber material to make.

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