CN105572488A - System used for detecting encephalic induced electric field induced by transcranial magnetic stimulation, and manufacturing method - Google Patents
System used for detecting encephalic induced electric field induced by transcranial magnetic stimulation, and manufacturing method Download PDFInfo
- Publication number
- CN105572488A CN105572488A CN201511035157.9A CN201511035157A CN105572488A CN 105572488 A CN105572488 A CN 105572488A CN 201511035157 A CN201511035157 A CN 201511035157A CN 105572488 A CN105572488 A CN 105572488A
- Authority
- CN
- China
- Prior art keywords
- imitates
- head model
- transcranial magnetic
- brain
- magnetic stimulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000011491 transcranial magnetic stimulation Methods 0.000 title claims abstract description 78
- 230000005684 electric field Effects 0.000 title claims abstract description 49
- 238000004519 manufacturing process Methods 0.000 title abstract description 3
- 210000004556 brain Anatomy 0.000 claims abstract description 75
- 239000000523 sample Substances 0.000 claims abstract description 38
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims abstract description 31
- 210000003625 skull Anatomy 0.000 claims abstract description 22
- 210000003128 head Anatomy 0.000 claims description 91
- 210000004761 scalp Anatomy 0.000 claims description 68
- 230000006698 induction Effects 0.000 claims description 35
- 238000000034 method Methods 0.000 claims description 24
- 239000000463 material Substances 0.000 claims description 20
- 238000004804 winding Methods 0.000 claims description 19
- 238000009434 installation Methods 0.000 claims description 12
- 210000001178 neural stem cell Anatomy 0.000 claims description 7
- 230000002093 peripheral effect Effects 0.000 claims description 5
- 230000008569 process Effects 0.000 claims description 4
- 238000010146 3D printing Methods 0.000 claims description 3
- 210000001259 mesencephalon Anatomy 0.000 claims description 3
- 230000001537 neural effect Effects 0.000 claims description 3
- 239000007779 soft material Substances 0.000 claims description 3
- 238000007711 solidification Methods 0.000 claims description 3
- 230000008023 solidification Effects 0.000 claims description 3
- 238000003860 storage Methods 0.000 claims description 3
- 238000002347 injection Methods 0.000 claims description 2
- 239000007924 injection Substances 0.000 claims description 2
- 238000001514 detection method Methods 0.000 abstract description 7
- 208000001840 Dandruff Diseases 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 7
- 238000009826 distribution Methods 0.000 description 7
- 239000003822 epoxy resin Substances 0.000 description 5
- 229920000647 polyepoxide Polymers 0.000 description 5
- 239000011780 sodium chloride Substances 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- 238000005259 measurement Methods 0.000 description 4
- 230000004936 stimulating effect Effects 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- 108010010803 Gelatin Proteins 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 229920000159 gelatin Polymers 0.000 description 3
- 239000008273 gelatin Substances 0.000 description 3
- 235000019322 gelatine Nutrition 0.000 description 3
- 235000011852 gelatine desserts Nutrition 0.000 description 3
- 239000010439 graphite Substances 0.000 description 3
- 229910002804 graphite Inorganic materials 0.000 description 3
- 239000010440 gypsum Substances 0.000 description 3
- 229910052602 gypsum Inorganic materials 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- IISBACLAFKSPIT-UHFFFAOYSA-N bisphenol A Chemical compound C=1C=C(O)C=CC=1C(C)(C)C1=CC=C(O)C=C1 IISBACLAFKSPIT-UHFFFAOYSA-N 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000005284 excitation Effects 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 239000007943 implant Substances 0.000 description 2
- 229920002379 silicone rubber Polymers 0.000 description 2
- 241000219109 Citrullus Species 0.000 description 1
- 235000012828 Citrullus lanatus var citroides Nutrition 0.000 description 1
- 230000036982 action potential Effects 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000003710 cerebral cortex Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000001054 cortical effect Effects 0.000 description 1
- 210000003792 cranial nerve Anatomy 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000003760 magnetic stirring Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000001272 neurogenic effect Effects 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000008844 regulatory mechanism Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 230000003936 working memory Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R29/00—Arrangements for measuring or indicating electric quantities not covered by groups G01R19/00 - G01R27/00
- G01R29/12—Measuring electrostatic fields or voltage-potential
- G01R29/14—Measuring field distribution
Landscapes
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Magnetic Treatment Devices (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Abstract
The invention provides a system used for detecting the encephalic induced electric field induced by transcranial magnetic stimulation, and a manufacturing method. The system comprises a transcranial magnetic stimulator, an oscilloscope, a head model simulating body, an electric field detection probe used for collecting a head model simulating body signal, and a calibrating device used for calibrating the electric field detection probe. The head model simulating body is arranged in the calibrating device through a fixing device; the output coil of the transcranial magnetic stimulator is arranged on the bottom of the calibrating device, and is tangent with the bottom of the head model simulating body; the electric field detection probe is fixed to the coordinatometer on the upper portion of the calibrating device; the signal collection terminal of the electric field detection probe is in connection with the head model simulating body, and the output terminal of the electric field detection probe is in connection with the oscilloscope through a lead. The thickness of a brain simulating body is 70-80 mm, the thickness of a cerebrospinal fluid simulating body is 3-6 mm, the thickness of a skull simulating body is 4-6.5 mm, and the thickness of a dandruff simulating body is 5-8 mm. The system can detect the encephalic induced electric field induced by transcranial magnetic stimulation with higher spatial resolution and accuracy.
Description
Technical field
The present invention relates to and a kind ofly detect the device of transcranial magnetic stimulation at encephalic induction field.Particularly relate to a kind of four layers of head model comprising brain fold structure imitate body for detecting transcranial magnetic stimulation in the system of encephalic induction field and method for making.
Background technology
Transcranial magnetic stimulation is a kind of cranial nerve stimulating technology of people's inventions such as the Barker of Xie Feier university of Britain in 1985, its principle utilizes time-varying magnetic field to act on cerebral cortex, thus produce at encephalic the action potential that induction field changes cortical neurogenic cell, affect the biostimulation technology of brain intracellular metabolite and neuroelectricity activity, have without wound, safety, skull can be penetrated carry out stimulating and the advantage of targeting, be widely used at present in the important brain science research such as working memory mechanism, emotion regulatory mechanism.
And in transcranial magnetic stimulation, it is the basic reason that it is playing a role in the electric field intensity of the induction field that encephalic produces.But the measurement of this electric field intensity is researcher's issues that need special attention always.At present, primarily of the measuring method of following several transcranial magnetic stimulation at encephalic induction field, first, adopt the method for emulation, by setting up artificial head model and transcranial magnetic stimulation stimulating coil model, excitation parameters being set, carrying out the detection of encephalic induction field space distribution.This kind of method can construct comparatively meticulous head model, but it is a kind of method based on computing machine and correlation computations software, has carried out certain simplification, there is the error of calculation to computation process.The second, adopt the method for saline slot to simulate the detection that half unbounded space carries out electric field intensity space distribution, the induction field space distribution of transcranial magnetic stimulation can be described to a certain extent.But, adopt the portion's accuracy of saline slot phantom bead lower, the restriction that measuring error is large.Main cause be saline slot from shape to CONSTRUCTED SPECIFICATION and the characteristic of conductivity and real head part have very large difference.In addition, a few studies person utilizes has the method for wound to implant detecting electrode on cortex surface to the space distribution of the induction field detecting transcranial magnetic stimulation and produce at encephalic.This kind of method has wound, there is certain potential safety hazard, and the spatial resolution of encephalic piezomagnetic theory is subject to the impact of implant electrode quantity and number, the spatial resolution causing it to detect electric field is lower, therefore, develops a kind of head model similar to true head part with conductivity in structure, it can be used as research tool, detect the piezomagnetic theory that transcranial magnetic stimulation produces, the research being applied to brain science for transcranial magnetic stimulation provides certain guidance and help, has great importance.
Summary of the invention
Technical matters to be solved by this invention is, provide the measurement transcranial magnetic stimulation of a kind of pinpoint accuracy, high spatial resolution induce encephalic Electric Field Distribution for detecting transcranial magnetic stimulation in the system of encephalic induction field and method for making.
The technical solution adopted in the present invention is: a kind of for detecting the system of transcranial magnetic stimulation at encephalic induction field, include transcranial magnetic stimulation device and oscillograph, also be provided with head model and imitate body, the electric field detector probe of body signal and the caliberating device for demarcating electric field detector probe is imitated for collection head model, wherein, described head model is imitated body and is arranged in described caliberating device by stationary installation, the output winding of described transcranial magnetic stimulation device is arranged on the bottom of described caliberating device and to imitate the bottom of body tangent with head model, described electric field detector probe is fixed on the coordinatometer on described caliberating device top, the signals collecting end of electric field detector probe connects described head model and imitates body, the output terminal of described electric field detector probe connects oscillograph by wire.
Described caliberating device includes: the inner housing imitating body for arranging head model, the upper port of described housing is hatch frame, the described coordinatometer for being fixed described electric field detector probe and demarcating, be arranged in the upper port of described housing, Neural stem cell port is formed in the bottom of described housing, for arranging output winding head model being imitated to the transcranial magnetic stimulation device that body stimulates, the periphery of described Neural stem cell port is formed with the groove of the wire that can run through between transcranial magnetic stimulation device and output winding.
Described coordinatometer includes: two ends are arranged on the X-axis scale that two symmetrical sides of housing upper port also can move horizontally along these described two sides, be arranged on the Y-axis scale on the side perpendicular with described X-axis scale of described housing, and respectively with described X-axis scale and the perpendicular Z axis scale be arranged on described X-axis scale of Y-axis scale, described Z axis scale can move up and down under the support of X-axis scale, the top of described electric field detector probe is fixed on described Z axis scale by the fixture be arranged on Z axis scale, the head model that the lower end of described electric field detector probe is inserted in the housing being arranged on described caliberating device is imitated in body.
Described stationary installation is the interior back up pad of imitating body for supporting described head model of housing being arranged on described caliberating device, described back up pad has the embedded hole imitating body for embedding head model, the diameter of described embedded hole is less than the diameter that described head model imitates body, and it is tangent that head model can be made to imitate the output winding of summit bottom body and transcranial magnetic stimulation device; Or described stationary installation can to embed and the head model be made up of soft material be positioned in the housing of described caliberating device imitates body fixed body, along described head model fixed body central shaft up/down perforation be formed with the through hole imitating body for installing described head model, described head model imitates body when being arranged in described through hole, described head model is imitated body and can be positioned in described through hole, and the output winding that head model imitates summit bottom body and transcranial magnetic stimulation device is tangent.
It is semi-round ball body structure that described head model imitates body, be disposed with by inboard to outside that brain imitates body, cerebrospinal fluid imitates body, skull imitates body and scalp layer imitates body, the outer peripheral face that described brain imitates body is formed with emulation ditch and returns structure, described cerebrospinal fluid is imitated emulation ditch that the medial surface of body and described brain imitate external side face and is returned structure and match, the signals collecting end of described electric field detector probe is inserted into brain and imitates in body, and the corresponding described scalp layer of output winding of described transcranial magnetic stimulation device imitates body.
Described head model is imitated in body: the thickness that brain imitates body is 70 ~ 80mm, and the thickness that cerebrospinal fluid imitates body is 3 ~ 6mm, and the thickness that skull imitates body is 4 ~ 6.5mm, and the thickness that scalp layer imitates body is 5 ~ 8mm.
Under the output frequency of transcranial magnetic stimulation device is 3k ~ 4kHz, the conductivity that described head model imitates that body midbrain imitates body, cerebrospinal fluid imitates body, skull imitates body and scalp layer imitates body corresponds to 0.1 ~ 0.3S/m, 2 ~ 4S/m, 0.01 ~ 0.03S/m, 0.25 ~ 0.35S/m respectively.
Imitating a method for making for body for detecting the head model of transcranial magnetic stimulation in the system of encephalic induction field, comprising the steps:
1) make scalp layer respectively and imitate body and brain model, wherein, the thickness that described scalp layer imitates body is 5 ~ 8mm, the thickness of described brain model is 70 ~ 80mm, comprise and imitate at scalp layer the first fixed leg that position corresponding on body and brain model is respectively provided with more than 2 respectively, wherein, scalp layer imitates the first fixed leg on body is the setting that can dismantle;
2) inside surface imitating body at the cortex made smears skull layer, and to imitate body thickness be 4 ~ 6.5mm;
3) brain model is put into inside surface to smear the scalp layer that skull layer imitates body and imitate inside body, and make the first fixed leg on brain model and scalp layer imitate the first fixed leg on body corresponding on, use the first geometrical clamp scalp layer to be imitated two the first fixed leg clampings corresponding on body and brain model respectively, thus make described brain model and described scalp layer imitate the gap being formed with 3 ~ 6mm between body;
4) in the gap that described brain model and described scalp layer are imitated between body, inject cerebrospinal fluid and imitate body material, use ultrasonator to carry out removing the process of bubble, then put into refrigerator cold-storage;
5) cerebrospinal fluid is imitated and to be formed with the cerebrospinal fluid that ditch returns structure after body material cooled is solidified and to imitate body, pull down scalp layer and imitate the first geometrical clamp on body and brain model, and scalp layer imitates the first fixed leg on body, take out brain model, imitate in body at cerebrospinal fluid and inject material that brain imitates body and obtain head model and imitate body.
Brain model described in step 1 is that employing standard brain 3D printing and making forms, Mimics is specifically utilized to carry out 3 D stereo modeling to standard Typical AVM image, generate STl document, 3D printer is utilized to print, its Plays brain adopt Montreal, CAN neural MRI brain map, first fixed leg of more than 2 is installed uniformly at the periphery of the brain model upper surface made.
It is adopt scalp layer to imitate mould to make that scalp layer described in step 1 imitates body, described scalp layer is imitated mould and is included external mold and internal mold, the semicircular shell of described external mold to be radius be 82 ~ 100mm, the hemisphere of described internal mold to be radius be 77 ~ 95mm, second fixed leg of more than 2 is respectively provided with in the position that the periphery of the upper surface of described external mold and internal mold upper surface is corresponding, internal mold is put into the inner side of external mold, and make the gap being formed with 5 ~ 8mm between internal mold and external mold, and make the second fixed leg on external mold corresponding with the second fixed leg on internal mold on, use the second geometrical clamp by two the second geometrical clamp clampings corresponding on external mold and internal mold respectively, in gap between described external mold and described internal mold, injector head cortex imitates body material, after scalp layer imitates body material solidification, pull down the second geometrical clamp on external mold and internal mold, take out the coagulum be formed between external mold and internal mold, be scalp layer and imitate body.
Of the present invention for detecting transcranial magnetic stimulation in the system of encephalic induction field and method for making, it is the device of measurement transcranial magnetic stimulation induction encephalic Electric Field Distribution of a kind of pinpoint accuracy, high spatial resolution, consider the conductivity characteristic of different head structure, make the head model comprising the imitative body material of four kinds, scalp, skull, cerebrospinal fluid and brain, the head of approaching to reality people to the full extent.Use the encephalic induction field that device of the present invention can be induced with higher spatial resolution, more accurately measurement transcranial magnetic stimulation.In device of the present invention, the method for making of head model is simple, the space distribution of the lower encephalic induction field intensity of different parameters transcranial magnetic stimulation excitation can be obtained, can be transcranial magnetic stimulation and provide valuable guidance for the research of related brain science, and the security of transcranial magnetic stimulation when applying can be improved to a certain extent.
Accompanying drawing explanation
Fig. 1 is that the present invention's entirety forms block diagram;
Fig. 2 is the structural representation of caliberating device in the present invention;
Fig. 3 is the upward view of caliberating device in the present invention;
Fig. 4 is the structural representation of the back up pad be arranged in the present invention in caliberating device;
Fig. 5 is the structural representation of stationary installation in the present invention;
Fig. 6 is the structural representation of electric field detector probe in the present invention;
Fig. 7 is the structure schematic top plan view that in the present invention, head model imitates body;
Fig. 8 is the cut-open view of Fig. 7;
Fig. 9 is manufactured with the schematic diagram that cerebrospinal fluid that ditch returns structure imitates body method in the present invention;
Figure 10 is the cut-open view of Fig. 9;
Figure 11 is the schematic top plan view of imitating mould in the present invention for making scalp layer;
Figure 12 is the cut-open view of Figure 11.
In figure
1: transcranial magnetic stimulation device 2: head model imitates body
21: brain imitates body 22: cerebrospinal fluid imitates body
23: skull imitates body 24: scalp layer imitates body
25: emulation ditch returns structure 26: brain model
3: electric field detector probe 4: oscillograph
5: stationary installation 51: head model fixed body
52: through hole 6: caliberating device
61: housing 611:X axle scale
612:Y axle scale 613:Z axle scale
614: fixture 62: coordinatometer
63: Neural stem cell port 64: groove
65: back up pad 66: embedded hole
7: output winding 8: external mold
9: internal mold 10: the first fixed leg
11: the first geometrical clamp 12: the second fixed legs
13: the second geometrical clamps
Embodiment
A kind ofly to be described in detail in the system of encephalic induction field and method for making for detecting transcranial magnetic stimulation of the present invention below in conjunction with embodiment and accompanying drawing.
As shown in Figure 1, of the present invention for detecting the system of transcranial magnetic stimulation at encephalic induction field, include transcranial magnetic stimulation device 1 and oscillograph 4, it is characterized in that, also be provided with head model and imitate body 2, the electric field detector probe 3 of body 2 signal and the caliberating device 6 for demarcating electric field detector probe 3 is imitated for collection head model, wherein, described head model is imitated body 2 and is arranged in described caliberating device 6 by stationary installation 5, the output winding 7 of described transcranial magnetic stimulation device 1 is arranged on the bottom of described caliberating device 6 and to imitate the bottom of body 2 tangent with head model, described electric field detector probe 3 is fixed on the coordinatometer 62 on described caliberating device 6 top, the signals collecting end of electric field detector probe 3 connects described head model and imitates body 2, the output terminal of described electric field detector probe 3 connects oscillograph 4 by wire.
As Fig. 2, shown in Fig. 3, described caliberating device 6 includes: the inner housing 61 imitating body 2 for arranging head model, the upper port of described housing 61 is hatch frame, the described coordinatometer 62 for being fixed described electric field detector probe 3 and demarcating, be arranged in the upper port of described housing 61, Neural stem cell port 63 is formed in the bottom of described housing 61, for arranging the output winding 7 head model being imitated to the transcranial magnetic stimulation device 1 that body 2 stimulates, the periphery of described Neural stem cell port 63 is formed with the groove 64 of the wire that can run through between transcranial magnetic stimulation device 1 and output winding 7.
As shown in Figure 2, described coordinatometer 62 includes: two ends are arranged on the X-axis scale 611 that two symmetrical sides of housing 61 upper port also can move horizontally along these described two sides, be arranged on the Y-axis scale 612 on the side perpendicular with described X-axis scale 611 of described housing 61, and respectively with described X-axis scale 611 and the perpendicular Z axis scale 613 be arranged on described X-axis scale 611 of Y-axis scale 612, described Z axis scale 613 can move up and down under the support of X-axis scale 611, the top of described electric field detector probe 3 is fixed on described Z axis scale 613 by the fixture 614 be arranged on Z axis scale 613, the head model that the lower end of described electric field detector probe 3 is inserted in the housing 61 being arranged on described caliberating device 6 is imitated in body 2.
As shown in Figure 4, described stationary installation 5 is the interior back up pads 65 of imitating body 2 for supporting described head model of housing being arranged on described caliberating device 6, described back up pad 65 has the embedded hole 66 imitating body 2 for embedding head model, the diameter of described embedded hole 66 is less than the diameter that described head model imitates body 2, and it is tangent that head model can be made to imitate the output winding 7 of summit bottom body 2 and transcranial magnetic stimulation device 1;
Or as shown in Figure 5, described stationary installation 5 can to embed and the head model be made up of soft material be positioned in the housing 61 of described caliberating device 6 imitates body fixed body 51, along described head model fixed body 51 central shaft up/down perforation be formed with the through hole 52 imitating body 2 for installing described head model, described head model imitates body 2 when being arranged in described through hole 52, described head model is imitated body 2 and can be positioned in described through hole 52, and the output winding 7 that head model imitates summit bottom body 2 and transcranial magnetic stimulation device 1 is tangent.
As shown in Figure 7, Figure 8, described head model imitates body 2 for semi-round ball body structure, be disposed with by inboard to outside that brain imitates body 21, cerebrospinal fluid imitates body 22, skull imitates body 23 and scalp layer imitates body 24, the outer peripheral face that described brain imitates body 21 is formed with emulation ditch and returns structure 25, described cerebrospinal fluid is imitated emulation ditch that the medial surface of body 22 and described brain imitate body 21 outer peripheral face and is returned structure 25 and match, the signals collecting end of described electric field detector probe 3 is inserted into brain and imitates in body 21, and the corresponding described scalp layer of output winding 7 of described transcranial magnetic stimulation device 1 imitates body 24.
Described head model is imitated in body 2: the thickness that brain imitates body 21 is 70 ~ 80mm, and the thickness that cerebrospinal fluid imitates body 22 is 3 ~ 6mm, and the thickness that skull imitates body 23 is 4 ~ 6.5mm, and the thickness that scalp layer imitates body 24 is 5 ~ 8mm.
Under the output frequency of transcranial magnetic stimulation device 1 is 3k ~ 4kHz, the conductivity that described head model imitates that body 2 midbrain imitates body 21, cerebrospinal fluid imitates body 22, skull imitates body 23 and scalp layer imitates body 24 corresponds to 0.1 ~ 0.3S/m, 2 ~ 4S/m, 0.01 ~ 0.03S/m, 0.25 ~ 0.35S/m respectively.
As shown in Figure 9, Figure 10, method for making of imitating body for detecting the head model of transcranial magnetic stimulation in the system of encephalic induction field of the present invention, comprises the steps:
1) make scalp layer respectively and imitate body 24 and brain model 26, wherein, the thickness that described scalp layer imitates body 24 is 5 ~ 8mm, the thickness of described brain model 26 is 70 ~ 80mm, comprise and imitate at scalp layer the first fixed leg 10 that the upper corresponding position of body 24 and model (221) is respectively provided with more than 2 respectively, wherein, scalp layer imitates the first fixed leg (10) on body (24) is the setting that can dismantle;
Described brain model 26 is that employing standard brain 3D printing and making forms, Mimics is specifically utilized to carry out 3 D stereo modeling to standard Typical AVM image, generate STl document, 3D printer is utilized to print, its Plays brain adopts the MRI brain map of the neural institute (MNI) of Montreal, CAN, installs first fixed leg 10 of more than 2 at the periphery of brain model 26 upper surface made uniformly.
As Figure 11, shown in Figure 12, step 1) described in scalp layer to imitate body 24 be adopt scalp layer to imitate mould to make, described scalp layer is imitated mould and is included external mold 8 and internal mold 9, the semicircular shell of described external mold 8 to be radiuses be 82 ~ 100mm, the hemisphere of described internal mold 9 to be radiuses be 77 ~ 95mm, second fixed leg 12 of more than 2 is respectively provided with in the position that the periphery of the upper surface of described external mold 8 and internal mold 9 upper surface is corresponding, internal mold 9 is put into the inner side of external mold 8, and make the gap being formed with 5 ~ 8mm between internal mold 9 and external mold 8, and make the second fixed leg 12 on external mold 8 corresponding with the second fixed leg 12 on internal mold 9 on, the second geometrical clamp 13 is used to be clamped by two the second geometrical clamps 13 corresponding on external mold 8 and internal mold 9 respectively, in gap between described external mold 8 and described internal mold 9, injector head cortex imitates body material, after scalp layer imitates body material solidification, pull down the second geometrical clamp 13 on external mold 8 and internal mold 9, take out the coagulum be formed between external mold 8 and internal mold 9, be scalp layer and imitate body 24.
2) inside surface imitating body 24 at the cortex made smears skull layer, and to imitate body 23 thickness be 4 ~ 6.5mm;
3) brain model 26 is put into inside surface to smear the scalp layer that skull layer imitates body 23 and imitate inside body 24, and make the first fixed leg 10 on brain model 26 and scalp layer imitate the first fixed leg 10 on body 24 corresponding on, use the first geometrical clamp 11 scalp layer to be imitated two the first fixed legs 10 corresponding on body 24 and brain model 26 respectively to clamp, thus make described brain model 26 and described scalp layer imitate the gap being formed with 3 ~ 6mm between body 24;
4) in the gap that described brain model 26 and described scalp layer are imitated between body 24, inject cerebrospinal fluid and imitate body material, use ultrasonator to carry out removing the process of bubble, then put into refrigerator cold-storage;
5) cerebrospinal fluid is imitated and to be formed with the cerebrospinal fluid that ditch returns structure after body material cooled is solidified and to imitate body 22, pull down scalp layer and imitate the first geometrical clamp 11 on body 24 and brain model 26, and scalp layer imitates the first fixed leg 10 on body 24, take out brain model 26, to imitate body 22 at cerebrospinal fluid material that injection brain imitates body 21 and obtain head model and imitate body 2.
In an embodiment of the present invention:
Described scalp layer imitates body 24, is to be made by epoxy resin and electrically conductive graphite, is joined in bisphenol A type epoxy resin by absolute ethyl alcohol and dilutes, and uses electric blender to stir.Electrically conductive graphite is joined in the epoxy resin of dilution, electric blender is used to stir, mix, then joining scalp layer imitates in mould, gets rid of bubble, put into constant temperature oven and be cured through supersonic oscillations, temperature is set to 200 °, solidify 8 hours, the then demoulding, then form scalp layer and imitate body 24.The mass ratio of epoxy resin, hardening agent, absolute ethyl alcohol, graphite is 40:10:6:3.Remaining conductive epoxy resin is cut into 3 pieces of length and widths, rectangular parallelepiped that height is respectively 10mm, 10mm, 5mm, use Agilent electric impedance analyzer 4294A and the 16451B fixture mated with it measure the conductivity of 3 pieces of field side's bodies, at the output frequency 3k ~ 4kHz of Magstim transcranial magnetic stimulation device, measure and be averaged for three times, the conductivity that acquisition scalp layer imitates body is 0.25 ~ 0.35S/m.
Described skull layer imitates body 23, by gypsum and pure water mixing manufacture, utilize electronic balance to take pure water and gesso that pigment mass ratio is 0.35:1, stirring rod is used to be mixed rapidly, utilize flat spoon to be applied to the inside surface of watermelon peel, smearing thickness is 7.5mm, gypsum normal temperature cure, use fine sandpaper to polish, form skull layer and imitate body.Adopt the proportioning of imitating the identical gypsum of body and pure water with skull layer, use the square grinding tool of silicon rubber, make 3 pieces of 3 pieces of length and widths, square that height is respectively 10mm, 10mm, 5mm, after cure and demold, use Agilent electric impedance analyzer 4294A and the 16451B fixture mated with it measure the conductivity of 3 pieces of squares, at the output frequency 3571Hz of Britain Magstim transcranial magnetic stimulation device, measure and be averaged for three times, the conductivity that acquisition scalp layer imitates body is 0.01 ~ 0.03S/m.
Described cerebrospinal fluid imitates body 22, adopt the mode of perfusion to be made by gelatin and pure water, concrete steps are: used by pure water constant temperature blender with magnetic force to be heated to 60 DEG C, then slowly gelatin is added, magnetic stirring apparatus is utilized to stir, and be heated to 85 DEG C, cool and solidify, the quality proportioning of gelatin and pure water is 0.02:1.Use the square grinding tool of silicon rubber, cerebrospinal fluid is used to imitate the square that body material makes 3 pieces of 3 pieces of length and widths, height is respectively 10mm, 10mm, 5mm, after the cooling curing demoulding, use Agilent electric impedance analyzer 4294A and the 16451B fixture mated with it measure the conductivity of 3 pieces of squares, at the output frequency 3k-4kHz of transcranial magnetic stimulation device, measure and be averaged for three times, the conductivity that acquisition cerebrospinal fluid imitates body is 2 ~ 4S/m.
Described brain imitates body 21, is to be mixed by sodium chloride and pure water, and carry out fully stirring being made, the quality proportioning of sodium chloride and pure water is 0.0085 ~ 0.0092:1.Use liquid electric conductivity tester to measure its conductivity, the conductivity that acquisition brain imitates body is 0.1 ~ 0.3S/m.
Described body stationary installation 5 of imitating 2 for gland model be adopt by be highly 150mm, the head model made of length is 300mm, width is 300mm rectangular parallelepiped sponge material imitates body fixed body 51, by the cylindrical hole 52 that its inside scissors is made into high 150mm, diameter is 190mm, head model can be imitated body and be fixed by it, prevents it from moving.
Described head model position label means 6 adopts pmma material to make, shape is the square shape that length is respectively 300mm, 300mm, 300mm, this square is without upper surface, lower surface has size to be respectively the oblong openings of 200mm*100mm, Eight characters coil used is stimulated for placing transcranial magnetic stimulation, the summit that coil and head model are imitated bottom body is tangent, the rectangle side opening being of a size of 60mm*100mm is had, for placing the wire of the Eight characters coil of transcranial magnetic stimulation device in oblong openings side.The minimum scale of the scale in X, Y that caliberating device 6 contains and Z axis 3 directions is 1mm, and three direction scales can move freely, and are fixed by the screw of pmma material.
Described transcranial magnetic stimulation device 1 is the Magstimrapid2 transcranial magnetic stimulation device adopting Magstim company of Britain to produce, and stimulating coil uses the Eight characters coil matched with this magnetic stimulator.The concentric cable of described electric field detector probe to be external diameter be 3mm, respectively using the wire of its inside and outside the two poles of the earth as probe in detecting, the distance between the two poles of the earth is 3mm.
Oscillograph 4 adopts Tyke oscillograph DPO2024, and it is connected to the two ends of electric field detector probe, and under synchronous recording, transcranial magnetic stimulation stimulates the magnitude of voltage U of electric field intensity reaction on oscillograph of induction.Because the two poles of the earth distance of electric field detector probe is d=3mm, therefore, can suppose that the electric field of transcranial magnetic stimulation induction in is among a small circle uniform, therefore, the calculating of electric field strength E can be carried out conversion and obtain by the magnitude of voltage U that oscillograph records, computing formula is:
E＝U/d
Of the present invention for detecting transcranial magnetic stimulation in the system of encephalic induction field and method for making, establish the four layers of head model returning structure containing ditch, for the predicament that current transcranial magnetic stimulation is measured at encephalic induction field, the imitative body head model making the conductivity and anatomical structure approaching true head is measured transcranial magnetic stimulation encephalic induction field, different parameters transcranial magnetic stimulation can be inferred with this, as different stimulated intensity etc., at the induction field that encephalic produces, estimate the effect that the transcranial magnetic stimulation that different normal form exports produces the different brain structure of encephalic, thus instruct the optimum configurations of correlation test, for the application of transcranial magnetic stimulation in brain science is offered help, and the security of transcranial magnetic stimulation when applying can be improved to a certain extent.
Claims (10)
1. one kind for detecting the system of transcranial magnetic stimulation at encephalic induction field, include transcranial magnetic stimulation device (1) and oscillograph (4), it is characterized in that, also be provided with head model and imitate body (2), the electric field detector probe (3) of body (2) signal and the caliberating device (6) for demarcating electric field detector probe (3) is imitated for collection head model, wherein, described head model is imitated body (2) and is arranged in described caliberating device (6) by stationary installation (5), the output winding (7) of described transcranial magnetic stimulation device (1) is arranged on the bottom of described caliberating device (6) and to imitate the bottom of body (2) tangent with head model, described electric field detector probe (3) is fixed on the coordinatometer (62) on described caliberating device (6) top, the signals collecting end of electric field detector probe (3) connects described head model and imitates body (2), the output terminal of described electric field detector probe (3) connects oscillograph (4) by wire.
2. according to claim 1 for detecting the system of transcranial magnetic stimulation at encephalic induction field, it is characterized in that, described caliberating device (6) includes: inside is used for arranging the housing (61) that head model imitates body (2), the upper port of described housing (61) is hatch frame, the described coordinatometer (62) for being fixed described electric field detector probe (3) and demarcating, be arranged in the upper port of described housing (61), Neural stem cell port (63) is formed in the bottom of described housing (61), for arranging the output winding (7) head model being imitated to the transcranial magnetic stimulation device (1) that body (2) stimulates, the periphery of described Neural stem cell port (63) is formed with the groove (64) of the wire that can run through between transcranial magnetic stimulation device (1) and output winding (7).
3. according to claim 1 and 2 for detecting the system of transcranial magnetic stimulation at encephalic induction field, it is characterized in that, described coordinatometer (62) includes: two ends are arranged on the X-axis scale (611) that two symmetrical sides of housing (61) upper port also can move horizontally along these described two sides, be arranged on the Y-axis scale (612) on the side perpendicular with described X-axis scale (611) of described housing (61), and respectively with described X-axis scale (611) and the perpendicular Z axis scale (613) be arranged on described X-axis scale (611) of Y-axis scale (612), described Z axis scale (613) can move up and down under the support of X-axis scale (611), the top of described electric field detector probe (3) is fixed on described Z axis scale (613) by the fixture (614) be arranged on Z axis scale (613), the lower end of described electric field detector probe (3) be inserted into be arranged on described caliberating device (6) housing (61) in head model imitate in body (2).
4. according to claim 1 for detecting the system of transcranial magnetic stimulation at encephalic induction field, it is characterized in that, described stationary installation (5) is the interior back up pad (65) of imitating body (2) for supporting described head model of housing being arranged on described caliberating device (6), described back up pad (65) has the embedded hole (66) imitating body (2) for embedding head model, the diameter of described embedded hole (66) is less than the diameter that described head model imitates body (2), and head model can be made to imitate the summit of body (2) bottom and the output winding (7) of transcranial magnetic stimulation device (1) tangent, or described stationary installation (5) can to embed and the head model be made up of soft material be positioned in the housing (61) of described caliberating device (6) imitates body fixed body (51), along described head model fixed body (51) central shaft up/down perforation be formed with the through hole (52) imitating body (2) for installing described head model, described head model imitate body (2) be arranged on described through hole (52) interior time, described head model is imitated body (2) and can be positioned in described through hole (52), and head model imitates the summit of body (2) bottom and the output winding (7) of transcranial magnetic stimulation device (1) is tangent.
5. according to claim 1 for detecting the system of transcranial magnetic stimulation at encephalic induction field, it is characterized in that, described head model imitates body (2) for semi-round ball body structure, be disposed with brain by inboard to outside and imitate body (21), cerebrospinal fluid imitates body (22), skull imitates body (23) and scalp layer imitates body (24), the outer peripheral face that described brain imitates body (21) is formed with emulation ditch and returns structure (25), described cerebrospinal fluid is imitated emulation ditch that the medial surface of body (22) and described brain imitate body (21) outer peripheral face and is returned structure (25) and match, the signals collecting end of described electric field detector probe (3) is inserted into brain and imitates in body (21), the corresponding described scalp layer of output winding (7) of described transcranial magnetic stimulation device (1) imitates body (24).
6. according to claim 5 for detecting the system of transcranial magnetic stimulation at encephalic induction field, it is characterized in that, described head model is imitated in body (2): the thickness that brain imitates body (21) is 70 ~ 80mm, the thickness that cerebrospinal fluid imitates body (22) is 3 ~ 6mm, the thickness that skull imitates body (23) is 4 ~ 6.5mm, and the thickness that scalp layer imitates body (24) is 5 ~ 8mm.
7. according to claim 5 for detecting the system of transcranial magnetic stimulation at encephalic induction field, it is characterized in that, under the output frequency of transcranial magnetic stimulation device (1) is 3k ~ 4kHz, the conductivity that described head model imitates that body (2) midbrain imitates body (21), cerebrospinal fluid imitates body (22), skull imitates body (23) and scalp layer imitates body (24) corresponds to 0.1 ~ 0.3S/m, 2 ~ 4S/m, 0.01 ~ 0.03S/m, 0.25 ~ 0.35S/m respectively.
8. the method for making of imitating body for detecting the head model of transcranial magnetic stimulation in the system of encephalic induction field according to any one of claim 1-7, is characterized in that, comprise the steps:
1) make scalp layer respectively and imitate body (24) and brain model (26), wherein, the thickness that described scalp layer imitates body (24) is 5 ~ 8mm, the thickness of described brain model (26) is 70 ~ 80mm, comprise and imitate at scalp layer the first fixed leg (10) that the upper corresponding position of body (24) and brain model (26) is respectively provided with more than 2 respectively, wherein, scalp layer imitates the first fixed leg (10) on body (24) is the setting that can dismantle;
2) inside surface imitating body (24) at the cortex made smears skull layer, and to imitate body (23) thickness be 4 ~ 6.5mm;
3) brain model (26) is put into inside surface to smear the scalp layer that skull layer imitates body (23) and imitate body (24) inner side, and make the first fixed leg (10) on brain model (26) and scalp layer imitate the first fixed leg (10) on body (24) corresponding on, use the first geometrical clamp (11) scalp layer to be imitated body (24) and upper two corresponding the first fixed leg (10) clampings of brain model (26) respectively, thus make described brain model (26) and described scalp layer imitate the gap being formed with 3 ~ 6mm between body (24);
4) in the gap that described brain model (26) and described scalp layer are imitated between body (24), inject cerebrospinal fluid and imitate body material, use ultrasonator to carry out removing the process of bubble, then put into refrigerator cold-storage;
5) cerebrospinal fluid is imitated and to be formed with the cerebrospinal fluid that ditch returns structure after body material cooled is solidified and to imitate body (22), pull down scalp layer and imitate the first geometrical clamp (11) on body (24) and brain model (26), and scalp layer imitates the first fixed leg (10) on body (24), take out brain model (26), to imitate body (22) at cerebrospinal fluid material that injection brain imitates body (21) and obtain head model and imitate body (2).
9. method for making of imitating body for detecting the head model of transcranial magnetic stimulation in the system of encephalic induction field according to claim 8, it is characterized in that, brain model (26) described in step 1 is that employing standard brain 3D printing and making forms, Mimics is specifically utilized to carry out 3 D stereo modeling to standard Typical AVM image, generate STl document, 3D printer is utilized to print, its Plays brain adopt Montreal, CAN neural MRI brain map, first fixed leg (10) of more than 2 is installed uniformly at the periphery of the brain model made (26) upper surface.
10. method for making of imitating body for detecting the head model of transcranial magnetic stimulation in the system of encephalic induction field according to claim 8, it is characterized in that, it is adopt scalp layer to imitate mould to make that scalp layer described in step 1 imitates body (24), described scalp layer is imitated mould and is included external mold (8) and internal mold (9), the semicircular shell of described external mold (8) to be radius be 82 ~ 100mm, the hemisphere of described internal mold (9) to be radius be 77 ~ 95mm, second fixed leg (12) of more than 2 is respectively provided with in the position that the periphery of the upper surface of described external mold (8) and internal mold (9) upper surface is corresponding, internal mold (9) is put into the inner side of external mold (8), and make the gap being formed with 5 ~ 8mm between internal mold (9) and external mold (8), and make the second fixed leg (12) on external mold (8) corresponding with the second fixed leg (12) on internal mold (9) on, use the second geometrical clamp (13) by external mold (8) and upper two corresponding the second geometrical clamp (13) clampings of internal mold (9) respectively, in gap between described external mold (8) and described internal mold (9), injector head cortex imitates body material, after scalp layer imitates body material solidification, pull down the second geometrical clamp (13) on external mold (8) and internal mold (9), taking-up is formed in the coagulum between external mold (8) and internal mold (9), be scalp layer and imitate body (24).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511035157.9A CN105572488B (en) | 2015-12-31 | 2015-12-31 | For detecting system and production method of the transcranial magnetic stimulation in encephalic induction field |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511035157.9A CN105572488B (en) | 2015-12-31 | 2015-12-31 | For detecting system and production method of the transcranial magnetic stimulation in encephalic induction field |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105572488A true CN105572488A (en) | 2016-05-11 |
| CN105572488B CN105572488B (en) | 2018-06-05 |
Family
ID=55882850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201511035157.9A Active CN105572488B (en) | 2015-12-31 | 2015-12-31 | For detecting system and production method of the transcranial magnetic stimulation in encephalic induction field |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105572488B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110491518A (en) * | 2019-07-31 | 2019-11-22 | 中国医学科学院生物医学工程研究所 | A kind of transcranial magnetic stimulation modeling and simulating method for task state |
| CN112704486A (en) * | 2021-01-14 | 2021-04-27 | 中国科学院自动化研究所 | TMS coil pose map generation method based on electromagnetic simulation calculation |
| CN113724562A (en) * | 2021-07-20 | 2021-11-30 | 西安交通大学 | Simulated craniocerebral model for transcranial ultrasonic scanning and preparation method thereof |
| CN114073820A (en) * | 2022-01-20 | 2022-02-22 | 中国科学院自动化研究所 | Position and posture positioning device, method and equipment of transcranial magnetic stimulation coil for brain atlas navigation |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070260107A1 (en) * | 2006-05-05 | 2007-11-08 | Mishelevich David J | Trajectory-based deep-brain stereotactic transcranial magnetic stimulation |
| CN201353206Y (en) * | 2009-02-24 | 2009-12-02 | 中国医学科学院生物医学工程研究所 | Phantom model used for cranial nerve magnetic stimulation induced electric field detection |
| US7753836B2 (en) * | 2006-06-15 | 2010-07-13 | The Trustees Of Columbia University In The City Of New York | Systems and methods for inducing electric field pulses in a body organ |
| CN104096316A (en) * | 2014-07-21 | 2014-10-15 | 中国医学科学院生物医学工程研究所 | H-shaped coil optimization method for deep brain transcranial magnetic stimulation |
| CN104740780A (en) * | 2015-03-20 | 2015-07-01 | 中国科学院电工研究所 | Electromagnetic positioning and navigation device for transcranial magnetic stimulator |
-
2015
- 2015-12-31 CN CN201511035157.9A patent/CN105572488B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070260107A1 (en) * | 2006-05-05 | 2007-11-08 | Mishelevich David J | Trajectory-based deep-brain stereotactic transcranial magnetic stimulation |
| US7753836B2 (en) * | 2006-06-15 | 2010-07-13 | The Trustees Of Columbia University In The City Of New York | Systems and methods for inducing electric field pulses in a body organ |
| CN201353206Y (en) * | 2009-02-24 | 2009-12-02 | 中国医学科学院生物医学工程研究所 | Phantom model used for cranial nerve magnetic stimulation induced electric field detection |
| CN104096316A (en) * | 2014-07-21 | 2014-10-15 | 中国医学科学院生物医学工程研究所 | H-shaped coil optimization method for deep brain transcranial magnetic stimulation |
| CN104740780A (en) * | 2015-03-20 | 2015-07-01 | 中国科学院电工研究所 | Electromagnetic positioning and navigation device for transcranial magnetic stimulator |
Non-Patent Citations (1)
| Title |
|---|
| 郑建斌: "经颅磁刺激中大鼠真实头模型感应电场分布的研究", 《中国优秀硕士学位论文全文数据库（电子期刊）》 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110491518A (en) * | 2019-07-31 | 2019-11-22 | 中国医学科学院生物医学工程研究所 | A kind of transcranial magnetic stimulation modeling and simulating method for task state |
| CN110491518B (en) * | 2019-07-31 | 2023-04-07 | 中国医学科学院生物医学工程研究所 | Transcranial magnetic stimulation modeling simulation method for task state |
| CN112704486A (en) * | 2021-01-14 | 2021-04-27 | 中国科学院自动化研究所 | TMS coil pose map generation method based on electromagnetic simulation calculation |
| US11369282B1 (en) | 2021-01-14 | 2022-06-28 | Institute Of Automation, Chinese Academy Of Sciences | Method for generating transcranial magnetic stimulation (TMS) coil pose atlas based on electromagnetic simulating calculation |
| CN113724562A (en) * | 2021-07-20 | 2021-11-30 | 西安交通大学 | Simulated craniocerebral model for transcranial ultrasonic scanning and preparation method thereof |
| CN114073820A (en) * | 2022-01-20 | 2022-02-22 | 中国科学院自动化研究所 | Position and posture positioning device, method and equipment of transcranial magnetic stimulation coil for brain atlas navigation |
| CN114073820B (en) * | 2022-01-20 | 2022-06-24 | 中国科学院自动化研究所 | Position and posture positioning device, method and equipment of transcranial magnetic stimulation coil for brain atlas navigation |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105572488B (en) | 2018-06-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105572488A (en) | System used for detecting encephalic induced electric field induced by transcranial magnetic stimulation, and manufacturing method | |
| Basser et al. | MR diffusion tensor spectroscopy and imaging | |
| Fuentes et al. | Analysis and measurements of magnetic field exposures for healthcare workers in selected MR environments | |
| Oswald et al. | Observation of flow and transport processes in artificial porous media via magnetic resonance imaging in three dimensions | |
| WO2006094005A2 (en) | A head phantom for simulating the patient response to magnetic stimulation | |
| Glover et al. | Measurement of electric fields induced in a human subject due to natural movements in static magnetic fields or exposure to alternating magnetic field gradients | |
| CN106377261A (en) | Body model for detecting quality of magnetic resonance function imaging and method | |
| Brown et al. | Scaling of transverse nuclear magnetic relaxation due to magnetic nanoparticle aggregation | |
| CN111000558B (en) | Method and system capable of accurately positioning and accurately calculating brain area | |
| CN116098605B (en) | Water mold for multi-nuclear-element synchronous integrated magnetic resonance imaging and using method thereof | |
| US8497680B2 (en) | Magnetic resonance method for quantification of molecular diffusion using double echo steady state sequences | |
| Kłodowski et al. | Innovative anisotropic phantoms for calibration of diffusion tensor imaging sequences | |
| CN103018268B (en) | Method for measuring agar gel strength through low-field NMR (nuclear magnetic resonance) | |
| Shmueli et al. | Design, construction and evaluation of an anthropomorphic head phantom with realistic susceptibility artifacts | |
| Liu et al. | Multichannel synchronous real-time transcranial magnetic stimulation magnetic field detection system based on FPGA | |
| Sadleir et al. | A controllably anisotropic conductivity or diffusion phantom constructed from isotropic layers | |
| Degirmenci et al. | Practical realization of magnetic resonance conductivity tensor imaging (MRCTI) | |
| Cho et al. | A new nuclear magnetic resonance imaging technique for unambiguous unidirectional measurement of flow velocity | |
| Erwati et al. | Application of electrical impedance tomography for imaging in bio-medical and material technology | |
| CN107997853A (en) | A kind of electronic bio integumentary system | |
| CN206434331U (en) | A kind of fMRI quality testing body mould | |
| CN220270511U (en) | Special equipment for detecting magnetic field and temperature of transcranial magnetic stimulation therapeutic apparatus | |
| CN211402230U (en) | Concrete resistance survey device among vibration process | |
| Selwyn | Phantoms for magnetic resonance imaging | |
| Chauhan et al. | Phantom Construction and Equipment Configurations for Characterizing Electrical Properties Using MRI |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20220214 Address after: 518107 18th floor, block B, high tech innovation center, guangqiao Road, Tianliao community, Yutang street, Guangming District, Shenzhen City, Guangdong Province Patentee after: SHENZHEN DELICA MEDICAL EQUIPMENT Co.,Ltd. Address before: 300192, 236 Bai Causeway Road, Tianjin, Nankai District Patentee before: CHINESE ACADEMY OF MEDICAL SCIENCES INSTITUTE OF BIOMEDICAL ENGINEERING |
|
| TR01 | Transfer of patent right | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 518107 18th floor, block B, high tech innovation center, guangqiao Road, Tianliao community, Yutang street, Guangming District, Shenzhen City, Guangdong Province Patentee after: Shenzhen Delikai Medical Electronics Co.,Ltd. Address before: 518107 18th floor, block B, high tech innovation center, guangqiao Road, Tianliao community, Yutang street, Guangming District, Shenzhen City, Guangdong Province Patentee before: SHENZHEN DELICA MEDICAL EQUIPMENT Co.,Ltd. |
|
| CP01 | Change in the name or title of a patent holder |