CN220270511U - Special equipment for detecting magnetic field and temperature of transcranial magnetic stimulation therapeutic apparatus - Google Patents
Special equipment for detecting magnetic field and temperature of transcranial magnetic stimulation therapeutic apparatus Download PDFInfo
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Abstract
The utility model relates to a special device for detecting magnetic field and temperature of a transcranial magnetic stimulation therapeutic apparatus, which comprises: the device comprises a bionic head die body, a special bracket, a magnetic field measuring probe, a temperature measuring module, a device host and a data line. The bionic head die body is composed of a thin spherical shell and a thick spherical shell, is arranged on a special bracket base, a magnetic field measuring probe is arranged on the top of a special bracket sliding block, and a device host is respectively connected with the magnetic field measuring probe and a temperature measuring module through data lines. The device measures the temperature of the magnetic field and the surface of the coil in the space where the die body is positioned; and calculating and analyzing the magnetic field measurement result to obtain the measurement result of maximum magnetic induction intensity, spatial magnetic field distribution, output frequency, stimulation pulse width and coil surface temperature. The method is suitable for detecting and calibrating core parameters in research and development and clinical use of the transcranial magnetic stimulation therapeutic apparatus, and ensures the use safety and effectiveness of the transcranial magnetic stimulation therapeutic apparatus.
Description
Technical Field
The utility model relates to special equipment for detecting magnetic field and temperature in the field of medical detectors, in particular to special equipment for detecting magnetic field and temperature of a transcranial magnetic stimulation therapeutic apparatus.
Background
The discovery and experimental verification of the phenomenon of magneto-optical flash (magnetosphene) at the end of the nineteenth century opens the way for magnetic fields to regulate human neural activity. After that, many scientific research teams perform stimulation experiments of tissues such as human muscles, peripheral nerves, cerebral cortex and the like by using magnetic fields, and abundant experimental data are accumulated. In 1985, the first transcranial magnetic stimulation (Transcranial Magnetic Stimulation, TMS) therapeutic apparatus was developed by Barker et al, royal Ha Lanjun Hospital, university of Sheffield, UK. The device utilizes a pulse magnetic field to stimulate nerve cells in a target area and generate an induction electric field so as to change the potential of nerve cell membranes and regulate the activity of the nerve cells. The TMS therapeutic instrument is widely applied to the fields of diagnosis and treatment of neurological diseases, mental disease treatment, rehabilitation physiotherapy, brain function detection and the like due to the advantages of non-invasive and nondestructive operation, simple operation and the like. Especially for mental diseases such as refractory depression, and the TMS treatment has remarkable curative effect.
With the increase of working pressure and the increase of life rhythm, the number of patients with various mental diseases is continuously increased, only one of the patients with depression is depressed, and the number of adult patients is more than 6000 ten thousand. TMS therapeutic apparatuses are rapidly spreading in hospitals of two or more levels as mental disease therapeutic apparatuses that have been confirmed to be effective. The TMS therapeutic apparatus is divided into a single pulse transcranial magnetic stimulation therapeutic apparatus, a paired pulse transcranial magnetic stimulation therapeutic apparatus, a repeated transcranial stimulation therapeutic apparatus and an burst pulse transcranial magnetic stimulation therapeutic apparatus according to different design modes of stimulation sequences. The repeated transcranial magnetic stimulation (repetitive Transcranial Magnetic Stimulation, rTMS) therapeutic apparatus has the greatest clinical application range and the highest popularity, and is a key concern for medical apparatus and instrument supervision institutions.
For standardizing the production and the use of TMS therapeutic equipment, different institutions at home and abroad have issued a plurality of technical standards for the equipment. New versions of medical device regulations (Medical Device Regulation, MDR; REGULATION (EU) 2017/745) were promulgated by the european union in 2017, wherein TMS therapeutic devices were divided into class B medical devices and required manufacturers to register as prescribed; the united states food and drug administration (Food and Drug Administration, FDA) divides TMS therapeutic apparatuses into two types of medical apparatuses, and technical data of parameters such as magnetic field characteristics (waveforms, timings, pulse widths, intensities, etc.), output waveforms, magnetic field spatial distribution, magnetic field intensity gradients, etc. are required to be provided when the rTMS therapeutic apparatuses are required to be registered in the Class II Special Controls Guidance Document: repetitive Transcranial Magnetic Stimulation (rTMS) Systems issued by the united states Food and Drug Administration (FDA); only medical industry standard YY/T0994-2015 for registration and inspection of TMS therapeutic apparatus is provided in China, and the standard only prescribes the accuracy of parameters such as magnetic induction intensity, output frequency, stimulation pulse width, timing and the like, but does not prescribe a specific detection method.
In combination with the domestic and foreign standards, the domestic standards pay more attention to quality control of equipment production and registration inspection links, and the clinical use safety and stimulation accuracy of the TMS therapeutic apparatus, especially the rTMS therapeutic apparatus, lack available detection equipment and special methods. When in clinical use, the TMS therapeutic apparatus uses extremely high current to generate a strong magnetic field (more than 1T), and the strong magnetic field directly acts on the brain of a human to generate an induction electric field. Transient brain dysfunction such as epilepsy may be induced if the stimulus intensity is too high; and the treatment effect can not be achieved if the stimulus intensity is too low, so that the ineffective electromagnetic exposure of the patient is increased. Therefore, the safety and accuracy of the stimulation of the TMS therapeutic instrument in the clinical use link are required to be detected and evaluated, so that the safety and reliability of the TMS therapy can be ensured.
According to faraday's law of electromagnetic induction, a varying current generates an alternating magnetic field that induces an electric field inside a substance. Therefore, when the TMS therapeutic apparatus is used, a magnetic field and an electric field are sequentially generated in a target area of the human brain. The electric field characteristic parameters are closely related to the brain tissue characteristic parameters, the electric fields induced by different individuals after the individuals receive TMS are different, and the electric field intensity measurement in the tissue needs to be received by a special antenna, so that the cost is high and the implementation is difficult. The characteristic parameters of the alternating magnetic field generated by the TMS therapeutic instrument are mainly determined by the performance of the equipment, the magnetic field is only influenced by the structure and the propagation distance of an object in the transmission process, and the magnetic field intensity measuring technology is mature and has lower realization cost. Therefore, by combining the existing domestic and foreign standards and published academic papers, the evaluation of the clinical use safety and the stimulation accuracy of the TMS therapeutic instrument is mainly developed around the generated magnetic field characteristic parameters and the change of the coil surface temperature during magnetic stimulation. At present, a main detection method for generating a magnetic field of a TMS therapeutic instrument is to establish a numerical model of a stimulation coil of the TMS therapeutic instrument by using an analog simulation technology, carry out current parameter assignment, and then obtain the spatial distribution of the magnetic field generated by the stimulation coil by using methods such as finite element analysis; and measuring by using a tesla meter to obtain the magnetic induction intensity value of the surface of the stimulation coil, and comparing and verifying the magnetic induction intensity value with the simulation result to prove the accuracy of the simulation result. The magnetic field detection method is mainly based on simulation and verification by actual measurement, and has two obvious defects.
First, the necessary detection motifs are absent. The magnetic field generated by the TMS therapeutic instrument directly acts on the human brain, although the magnetic field does not generate loss when passing through different substances in the space transmission process in theory, in order to ensure that the simulation result is as close as possible to the actual stimulation result, a bionic head model numerical model is established and the electromagnetic field distribution in the model is acquired at the same time; in addition, the detection method is mainly based on measured data and is assisted by analog simulation, the bionic head die body with human head equivalence is researched and developed, and the magnetic field characteristic parameters generated by the TMS therapeutic instrument are evaluated by actually measuring the magnetic field intensity of the typical position in the simulated head die body. The equivalence of the bionic head die body mainly examines structural equivalence and electromagnetic characteristic parameter equivalence, but no mature product suitable for TMS therapeutic instrument detection exists in the current commercial die body.
Second, there is a lack of available magnetic field measurement probes. The TMS therapeutic instrument generates damping current in the stimulating coil with a pulse width of about 400 mu s, and the frequency of the alternating magnetic field excited by the damping current is about 2.8kHz. According to the Nyquist sampling theorem, in order to ensure that the acquired magnetic field signals are not distorted, the sampling frequency of the magnetic field measurement probe should reach at least 6kHz. Meanwhile, according to simulation results, the instantaneous value of the alternating magnetic field intensity generated on the surface of the stimulation coil of different TMS therapeutic instruments can reach 4T, so that the magnetic field intensity on the surface of the coil can be measured, the measuring range of the magnetic field measuring probe at least needs to be covered by 0-4T, and the three-dimensional orthogonal magnetic field intensity data acquisition and analysis can be realized. At present, few commercial tesla meters capable of simultaneously meeting triaxial measurement, 6kHz sampling frequency and 0-4T measurement range are available, and limited products are required to be customized and developed according to detection requirements, so that the cost is high.
In view of the above-mentioned drawbacks of the prior art, the present inventors have made continuous studies and designs, and have made repeated attempts and improvements, and finally have devised the present utility model which has a practical value.
Disclosure of Invention
The utility model mainly aims to provide a novel special device capable of being used for detecting the magnetic field and the temperature of a transcranial magnetic stimulation therapeutic apparatus, and aims to solve the technical problems of developing a bionic head model with human head equivalence, developing a triaxial magnetic field measuring probe with high sampling frequency and wide range, realizing detection of characteristic parameters such as maximum magnetic induction intensity, spatial magnetic field distribution, output frequency, stimulation pulse width, coil surface temperature and the like of an alternating magnetic field generated by a TMS therapeutic apparatus, improving and guaranteeing accuracy and availability degree of a detection result through evaluation of uncertainty of the detection result, and guaranteeing safety and effectiveness of use of the TMS therapeutic apparatus.
The aim and the technical problems of the utility model are realized by adopting the following technical proposal. The special equipment for detecting the magnetic field and the temperature of the transcranial magnetic stimulation therapeutic apparatus comprises a temperature measurement module, a device host and a data line of the device host, wherein the data line of the device host is connected with the temperature measurement module, and the special equipment also comprises a bionic head die body, a special bracket and a magnetic field measurement probe;
The bionic head die body consists of a thin spherical shell positioned at the upper layer and a thick spherical shell positioned at the lower layer, the thin spherical shell and the thick spherical shell are integrated structures which are respectively made of cylindrical acrylic base materials through cutting, the bionic head die body is arranged on a base, a magnetic field measuring probe is arranged at the top of a sliding block of a special bracket, and the magnetic field measuring probe is connected with a device host through a data line of the device host.
Further, the thin spherical shell consists of a thin spherical shell main body and a thin spherical shell edge, wherein the thin spherical shell main body is a hemisphere with the wall thickness not exceeding 3mm and the inner diameter of 140-150 mm, a first thin spherical shell liquid guide hole, a second thin spherical shell liquid guide hole, a third thin spherical shell liquid guide hole and a fourth thin spherical shell liquid guide hole are symmetrically etched at the positions of 0 DEG, 90 DEG, 180 DEG and 270 DEG on the lower edge of the thin spherical shell edge, and an annular groove is etched at the position, close to the thin spherical shell main body, of the lower edge of the thin spherical shell edge; the thick spherical shell consists of a thick spherical shell main body and a thick spherical shell edge, wherein the thick spherical shell main body is a semi-spherical shell with the wall thickness not exceeding 12mm and the inner diameter of 150-165 mm, a first annular bulge is arranged above the thick spherical shell edge and along the inner edge of the thick spherical shell main body, the first thick spherical shell liquid guide hole, the second thick spherical shell liquid guide hole, the third thick spherical shell liquid guide hole and the fourth thick spherical shell liquid guide hole are respectively etched symmetrically at the positions of 0 DEG, 90 DEG, 180 DEG and 270 DEG of the first annular bulge, the first thick spherical shell liquid guide hole, the second thick spherical shell liquid guide hole, the third thick spherical shell liquid guide hole and the fourth thick spherical shell liquid guide hole are respectively etched on the side surface of the thick spherical shell edge and are opposite to the central positions of the first thick spherical shell liquid guide hole, the second thick spherical shell liquid guide hole, the third thick spherical shell liquid guide hole and the fourth thick spherical shell liquid guide hole, the first annular bulge is embedded into an annular groove, and the diameters of the first thick spherical shell liquid guide hole, the second thick spherical shell liquid guide hole, the third thick spherical shell liquid guide hole and the fourth thick spherical shell liquid guide hole are the same as the first spherical shell liquid guide hole, the second spherical shell liquid guide hole and the fourth spherical shell liquid guide hole.
Further, the special bracket is made of nylon base material through cutting, and consists of a base, a cross rod, a threaded rod and a sliding block;
the upper surface of the base is internally etched to form a cylindrical through hole, the inner diameter of the cylindrical through hole is larger than the outer diameter of the thick spherical shell main body, the depth of the cylindrical through hole is larger than the radius of the thick spherical shell main body, an annular liquid retaining groove is etched on the upper surface of the base, a second annular bulge is formed between the annular liquid retaining groove and the cylindrical through hole, and a positioning line is symmetrically etched on the outer side surface of the second annular bulge at the positions of 0 DEG, 90 DEG, 180 DEG and 270 DEG respectively; symmetrically etching four groups of first round hole arrays, second round hole arrays, third round hole arrays and fourth round hole arrays with the same inner diameter at the positions of 0 degrees, 90 degrees, 180 degrees and 270 degrees, which are close to the outer side area, of the upper surface of the base, wherein each group of round hole arrays comprises 3 round holes with the same inner diameter and threads arranged in the inner part, and the circle centers of adjacent round holes in each group of round hole arrays are identical in connecting line distance; a first rectangular through hole is formed in the side face of the lower part of the base, the first rectangular through hole and the cylindrical through hole form a communication structure, the width of the first rectangular through hole is not less than 200mm, the height of the first rectangular through hole is not less than 50mm, and the distance between the lower edge of the first rectangular through hole and the bottom face of the base is not less than 20mm;
The two sides of the cross rod are symmetrically etched with a first round through hole and a second round through hole, the side face of the cross rod is vertically etched with a first side round through hole and a second side round through hole, the first round through hole is communicated with the first side round through hole, and the second round through hole is communicated with the second side round through hole; threads are arranged in the first side round through hole and the second side round through hole, and the screws penetrate through the first side round through hole and the second side round through hole and are screwed, so that the cross rod is kept at a fixed height on the threaded rod; etching a second rectangular through hole in the middle of the cross rod;
the threaded rod comprises two identical first threaded rods and second threaded rods, threads are arranged at the bottom of each threaded rod and can be screwed into any one of the first round hole array, the second round hole array, the third round hole array and the fourth round hole array, and the top diameters of the first threaded rod and the second threaded rod are smaller than the inner diameters of the first round through hole and the second round through hole;
the sliding block consists of a left sliding block and a right sliding block which are identical in structure and symmetrical to each other, a rectangular block at the upper half part of the left sliding block is provided with a first symmetrical through hole and a second symmetrical through hole in a drilling mode, and a square block at the lower half part of the left sliding block is provided with a first through hole in a drilling mode; the rectangular block at the upper half part of the right sliding block is provided with a third symmetrical through hole and a fourth symmetrical through hole corresponding to the first symmetrical through hole, the square block at the lower half part of the right sliding block is provided with a second through hole corresponding to the first through hole, and the inner walls of all four symmetrical through holes, the first through hole and the second through hole are provided with threads;
The upper surface of the left sliding block and the right sliding block which are assembled into a whole is provided with a top through hole;
the lower half part of the sliding block is provided with a T-shaped through hole, and the cross rod can be embedded into the upper half part of the T-shaped through hole;
the upper end of the first threaded rod and the upper end of the second threaded rod respectively penetrate through the first round through hole and the second round through hole, then plastic screws respectively penetrate through the first side round through hole and the second side round through hole and are screwed, and therefore the relative positions of the cross rod and the first threaded rod and the second threaded rod are fixed; the lower end of the first threaded rod is in threaded connection with any round hole in the first round hole array, the lower end of the second threaded rod is in threaded connection with a round hole in the third round hole array, which is symmetrical to the round hole connected with the first threaded rod, and at the moment, a circle center connecting line between the round hole connected with the first threaded rod and the round hole connected with the second threaded rod is parallel to a circle center connecting line of all round holes in the second round hole array and a circle center connecting line of all round holes in the fourth round hole array;
or any round hole in the first threaded rod lower end and the second round hole array is in threaded connection, the round hole in the fourth round hole array symmetrical to the round hole connected with the first threaded rod lower end is in threaded connection with the round hole connected with the first threaded rod lower end, and at the moment, the circle center connecting line between the round hole connected with the first threaded rod and the round hole connected with the second threaded rod is parallel to the circle center connecting line of all round holes in the first round hole array and the circle center connecting line of all round holes in the third round hole array.
Further, when assembling the bionic head die body, firstly placing the thick spherical shell on the base, then injecting cerebrospinal fluid equivalent solution into the thick spherical shell until the liquid level reaches one third of the height of the inner part of the thick spherical shell, then slowly placing the thin spherical shell into the thick spherical shell, and enabling the cerebrospinal fluid equivalent solution to flow upwards along the outer wall of the thick spherical shell due to extrusion of the thin spherical shell; rotating the thin spherical shell to enable the first annular bulge to be embedded into the annular groove, and enabling the first thin spherical shell liquid guide hole, the second thin spherical shell liquid guide hole, the third thin spherical shell liquid guide hole and the fourth thin spherical shell liquid guide hole to be aligned with the first thick spherical shell liquid guide hole, the second thick spherical shell liquid guide hole, the third thick spherical shell liquid guide hole and the fourth thick spherical shell liquid guide hole respectively; the cerebrospinal fluid equivalent solution exceeding the intermediate space volume of the thin spherical shell and the thick spherical shell is accumulated in the annular liquid retaining groove after being discharged through the first thin spherical shell liquid guide hole, the second thin spherical shell liquid guide hole, the third thin spherical shell liquid guide hole, the fourth thin spherical shell liquid guide hole and the first thick spherical shell liquid guide hole, the second thick spherical shell liquid guide hole, the third thick spherical shell liquid guide hole and the fourth thick spherical shell liquid guide hole; finally, injecting the brain gray matter equivalent solution into the thin spherical shell until the liquid level reaches four fifths of the height of the inside of the thin spherical shell.
Further, the method for preparing the cerebrospinal fluid equivalent solution and the brain ash equivalent solution is to take primary pure water as a basic substance, and adjust the conductivity and the relative dielectric constant of the tissue equivalent solution by adding salts and saccharides, so that the conductivity and the relative dielectric constant of the two equivalent solutions are respectively equivalent to that of the cerebrospinal fluid and the brain ash of a real human body, wherein the conductivity of the cerebrospinal fluid of the real human body is 1.00-2.51S/m, the relative dielectric constant is 109+/-30, the conductivity of the brain ash of the real human body is 0.06-2.47S/m, and the relative dielectric constant is 85600+/-25000. The relative dielectric constants were all measured and calibrated at a frequency of 2.8 kHz.
Further, the magnetic field measuring probe comprises a probe main body and a protective shell, three high-precision Hall elements are arranged in the probe main body, the three Hall elements are distributed in a three-dimensional orthogonal mode in space and fixed in the cuboid probe main body, and the Hall elements generate voltage signals after being stimulated by an alternating magnetic field and are converted into magnetic field signals; the data wire of the device host is connected with the three high-precision Hall elements, then penetrates out from the upper part of the probe main body, and then penetrates through the protective shell and then is connected with the device host; after the probe body is assembled, the probe body is impregnated with resin rubber to realize waterproof sealing of the Hall element and the circuit board thereof, and the protective shell is vertically fixed on the upper surface of the probe body; the diameter of the probe main body is smaller than that of the second rectangular through hole, the outer diameter of the protective shell is the same as the inner diameter of the top through hole, and a positioning wire is etched at the upper position of the protective shell and used for positioning during the assembly of the special bracket;
The magnetic field measuring probe is arranged in the second rectangular through hole, the left sliding block and the right sliding block clamp the protective shell, the positioning line on the protective shell is aligned with the lower surface of the T-shaped through hole, and the cross rod is embedded into the upper half part of the T-shaped through hole;
the plastic screws respectively pass through the first symmetrical through hole, the third symmetrical through hole, the second symmetrical through hole and the fourth symmetrical through hole and are fixed through nuts; the plastic screw is in threaded connection with the first through hole and screwed, so that the sliding block is fixed on the cross rod.
Further, the temperature measurement module comprises a platinum resistance temperature sensor, and a signal generated by the platinum resistance temperature sensor is transmitted to the device host through a data line of the device host; the device host is internally provided with a virtual oscilloscope module, so that the processing and the storage of voltage signals generated by the Hall element in the probe main body and voltage signals generated by the temperature measuring module are realized.
Compared with the prior art, the utility model has obvious advantages and beneficial effects. It has at least the following advantages:
1. the bionic head die body is of a double-layer spherical shell structure made of acrylic materials, a thick spherical shell is used for simulating human skull, a thin spherical shell is used for separating cerebrospinal fluid equivalent solution and brain grey matter equivalent solution, the sum of the thickness of the thick spherical shell and the thickness of the thin spherical shell is similar to the thickness of the human skull, the width of a gap between the thick spherical shell and the thin spherical shell is similar to the thickness of the human cerebrospinal fluid layer, and the inner diameter of the thin spherical shell is similar to the size of the human brain grey matter; the bionic head die body formed by the thick spherical shell and the thin spherical shell has a structure similar to that of the head of a human body, and the die body can approximate the real situation of the head of the human body in terms of structural morphology.
2. The bionic head die body developed by the utility model is made of acrylic materials, and the biological electromagnetic properties of the bionic head die body are similar to those of human bones; the conductivity and the dielectric constant of the cerebrospinal fluid equivalent solution and the brain gray matter equivalent solution which are poured into the bionic head phantom are equivalent to those of the corresponding human tissues; since the dielectric constant measurement results are related to the frequency of the electromagnetic field environment to which the tissue equivalent solution is applied, the solution dielectric constant measurement is performed at the frequency of 2.8kHz of the alternating magnetic field commonly used in TMS therapeutic equipment.
3. The magnetic field measuring probe developed by the utility model develops a triaxial orthogonal measuring probe from a component level (Hall element), and can realize the measurement of alternating magnetic field intensity; because the frequency of the alternating magnetic field commonly used by the TMS therapeutic instrument is 2.8kHz, the sampling frequency of the magnetic field measuring probe developed by the utility model reaches 10kHz, the measuring range covers (0-4) T and the measuring resolution is 25mT according to the Nyquist sampling theorem, and the waveform of the stimulation sequence obtained by acquisition can be ensured not to be distorted.
The foregoing description is only an overview of the present utility model, and is intended to provide a better understanding of the present utility model, as it is embodied in the following description, with reference to the preferred embodiments of the present utility model and the accompanying drawings.
Drawings
Fig. 1A: the embodiment 1 of the utility model is a schematic structural diagram of a special device for detecting magnetic field and temperature of a transcranial magnetic stimulation therapeutic apparatus.
Fig. 1B: the embodiment 2 of the utility model is a schematic structural diagram of special equipment for detecting the magnetic field and the temperature of the transcranial magnetic stimulation therapeutic apparatus.
Wherein:
1: bao Qiuke 2: thick spherical shell
3: base 4: cross bar
5: threaded rod 6: sliding block
7: magnetic field measurement probe 8: temperature measuring module
9: device host 10: data line of device host
11: control computer
Fig. 2A: the utility model discloses a bionic head die body structure schematic diagram.
Fig. 2B: the thin spherical shell structure of the bionic head die body is schematically shown.
Wherein:
1: bao Qiuke
1-1: first thin spherical shell liquid guide hole 1-2: second thin spherical shell liquid guide hole
1-3: third thin spherical shell liquid guide hole 1-4: fourth thin spherical shell liquid guide hole
1-5: thin spherical shell body 1-6: bao Qiuke edge
1-7: annular groove
Fig. 2C: the thick spherical shell structure of the bionic head die body is schematically shown.
Wherein:
2: thick spherical shell
2-1: first thick spherical shell liquid guide hole 2-2: second thick spherical shell liquid guide hole
2-3: and a third thick spherical shell liquid guide hole 2-4: fourth thick spherical shell liquid guide hole
2-5: thick spherical shell main body 2-6: thick spherical shell edge
2-7: a first annular protrusion
Fig. 3A: the special bracket structure of the utility model is schematically shown.
Fig. 3B: the base structure of the special bracket is schematically shown.
Wherein:
3: base seat
3-1: first circular hole array 3-2: second circular hole array
3-3: third circular hole array 3-4: fourth round hole array
3-5: annular liquid retaining groove 3-6: second annular protrusion
3-7: cylindrical through hole 3-8: first rectangular through hole
Fig. 3C: cross bar structure schematic diagram of special bracket of the utility model
Wherein:
4: cross bar
4-1: first round through hole 4-2: second round through hole
4-3: first side round through hole 4-4: second side round through hole
4-5: second rectangular through hole
Fig. 3D: the threaded rod structure of the special bracket is schematically shown.
5: threaded rod
5-1: first threaded rod 5-2: second threaded rod
Fig. 3E: the left side view schematic diagram of the sliding block structure of the special bracket is provided.
Fig. 3F: the right side view schematic diagram of the sliding block structure of the special bracket is shown.
Wherein:
6: sliding block
6-1: left slider 6-2: right slide block
6-3: first symmetrical through hole 6-4: second symmetrical through hole
6-5: third symmetrical through hole 6-6: fourth symmetrical through hole
6-7: first through hole 6-8: second through hole
6-9: top through hole 6-10: t-shaped through hole
Fig. 4A: the magnetic field measuring probe structure of the utility model is schematically shown.
Wherein:
7: magnetic field measuring probe
7-1: probe body 7-2: protective casing
Fig. 4B: the internal structure of the probe body of the magnetic field measuring probe is shown in the schematic diagram.
Fig. 5: the utility model relates to a schematic diagram of the measuring position of the maximum magnetic induction intensity and the coil surface temperature.
Wherein:
12: stimulating coil
12-1: measurement position 1 12-2: measuring position 2
12-3: measurement positions 3 11-4: measuring position 4
Fig. 6: the utility model discloses a schematic diagram of a measurement point of spatial magnetic field distribution.
Detailed Description
In order to further describe the technical means and effects adopted by the utility model to achieve the preset aim, the following description refers to the specific implementation, the method, the steps, the characteristics and the effects of the special equipment for detecting the magnetic field and the temperature of the transcranial magnetic stimulation therapeutic apparatus according to the utility model by combining the attached drawings and the preferred embodiment.
Example 1: referring to fig. 1A, a special device for detecting magnetic field and temperature of a transcranial magnetic stimulation therapeutic apparatus according to a preferred embodiment of the present utility model includes a bionic head phantom, a special bracket, a magnetic field measuring probe 7, a temperature measuring module 8, a device host 9 and a data line 10 of the device host; the bionic head die body is arranged on a base 3 of the special bracket, the magnetic field measuring probe 7 is arranged on the top of a sliding block 6 of the special bracket, and the device host 9 is respectively connected with the magnetic field measuring probe 7 and the temperature measuring module 8 through a data line 10 of the device host; the temperature measuring module 8 comprises a platinum resistance temperature sensor, a signal generated by the temperature sensor is transmitted to the device host 9 through a data line 10 of the device host, and a virtual oscilloscope module is built in the device host 9, so that the processing and the storage of a voltage signal generated by a Hall element in the probe main body 7-1 and a voltage signal generated by the temperature measuring module 9 are realized.
Referring to fig. 2A, the bionic head die body is composed of a thin spherical shell 1 and a thick spherical shell 2, wherein the thin spherical shell 1 and the thick spherical shell 2 are an integral structure which is made of a cylindrical acrylic substrate through cutting.
Referring to fig. 2B, the thin spherical shell 1 is composed of a thin spherical shell main body 1-5 and a thin spherical shell edge 1-6, wherein the thin spherical shell main body 1-5 is a hemisphere with a wall thickness not exceeding 3mm and an inner diameter of 140-150 mm, a first thin spherical shell liquid guide hole 1-1, a second thin spherical shell liquid guide hole 1-2, a third thin spherical shell liquid guide hole 1-3 and a fourth thin spherical shell liquid guide hole 1-4 are symmetrically etched at positions of 0 °, 90 °, 180 ° and 270 ° on the lower edge of the thin spherical shell edge 1-6, respectively, and an annular groove 1-7 is etched at the position of the lower edge of the thin spherical shell edge 1-6 close to the thin spherical shell main body 1-5.
Referring to fig. 2C, the thick spherical shell 2 is composed of a thick spherical shell main body 2-5 and a thick spherical shell edge 2-6, wherein the thick spherical shell main body 2-5 is a hemisphere with a wall thickness not exceeding 12mm and an inner diameter of 150-165 mm, a first annular bulge 2-7 is arranged above the thick spherical shell edge 2-6 and along the inner edge of the thick spherical shell main body 2-5, a positioning line is respectively etched at the center position of the first annular bulge 2-7 at the positions of 0 °, 90 °, 180 ° and 270 °, respectively and symmetrically, the first thick spherical shell liquid guiding hole 2-1, the second thick spherical shell liquid guiding hole 2-2, the third thick spherical shell liquid guiding hole 2-3 and the fourth thick spherical shell liquid guiding hole 2-4 are respectively etched, and the first annular bulge 2-7, the second spherical shell liquid guiding hole 2-3 and the fourth spherical shell liquid guiding hole 2-1 are respectively and symmetrically arranged at the center positions of the first annular bulge 2-7, the second thick spherical shell liquid guiding hole 2-4, the third thick spherical shell liquid guiding hole 2-3 and the first thick spherical shell liquid guiding hole 2-1, the third thick spherical shell liquid guiding hole 2-1 and the fourth spherical shell liquid guiding hole 2-4 are respectively embedded in the side surface of the thick spherical shell edge 2-6, and the first thick spherical shell liquid guiding hole 2-1-6 is opposite to the first thick spherical shell liquid guiding hole 2-1.
Referring to fig. 3A and 3B, the special bracket is made of nylon base material by cutting, and is composed of a base 3, a cross rod 4, a threaded rod 5 and a sliding block 6. Forming a cylindrical through hole 3-7 on the upper surface of the base 3 by inwards etching, wherein the inner diameter of the cylindrical through hole 3-7 is larger than the outer diameter of the thick spherical shell main body 2-5, the depth of the cylindrical through hole 3-7 is larger than the radius of the thick spherical shell main body 2-5, an annular liquid retaining groove 3-5 is etched on the upper surface of the base 3, a second annular bulge 3-6 is formed between the annular liquid retaining groove 3-5 and the cylindrical through hole 3-7, a positioning line is symmetrically etched at the positions of 0 DEG, 90 DEG, 180 DEG and 270 DEG on the outer side surface of the second annular bulge 3-6, four groups of first round hole arrays 3-1, second round hole arrays 3-2, third round hole arrays 3-3 and fourth round hole arrays 3-4 with the same inner diameters are symmetrically etched at the positions of 0 DEG, 90 DEG, 180 DEG and 270 DEG on the upper surface of the base 3 near the outer side area, each group of round hole arrays comprises round holes with threads with the same inner diameters, and the circle center line connecting distances of adjacent round holes in each group of round hole arrays are the same; the side surface of the lower part of the base 3 is provided with a first rectangular through hole 3-8, the first rectangular through hole 3-8 and the cylindrical through hole 3-7 form a communication structure, the width of the first rectangular through hole 3-8 is not less than 200mm, the height of the first rectangular through hole is not less than 50mm, and the distance between the lower edge of the first rectangular through hole 3-8 and the bottom surface of the base 3 is not less than 20mm.
Referring to fig. 1, 2A, 3A and 3B, when assembling the bionic head mold, firstly, placing the thick spherical shell 2 on a base, then injecting cerebrospinal fluid equivalent solution into the thick spherical shell 2 until the liquid level reaches one third of the inner height of the thick spherical shell 2, then slowly placing the thin spherical shell 1 into the thick spherical shell 2, and allowing the cerebrospinal fluid equivalent solution to flow upwards along the outer wall of the thin spherical shell 1 due to extrusion of the thin spherical shell 1; rotating the thin spherical shell 1 to enable the first annular 2-7 bulge to be embedded into the annular groove 1-7, and enabling the first thin spherical shell liquid guide hole 1-1, the second thin spherical shell liquid guide hole 1-2, the third thin spherical shell liquid guide hole 1-3 and the fourth thin spherical shell liquid guide hole 1-4 to be aligned with the first thick spherical shell liquid guide hole 2-1, the second thick spherical shell liquid guide hole 2-2, the third thick spherical shell liquid guide hole 2-3 and the fourth thick spherical shell liquid guide hole 2-4 respectively; cerebrospinal fluid equivalent solution exceeding the intermediate space volume of the thin spherical shell 1 and the thick spherical shell 2 is discharged through the first thin spherical shell liquid guide hole 1-1, the second thin spherical shell liquid guide hole 1-2, the third thin spherical shell liquid guide hole 1-3 and the fourth thin spherical shell liquid guide hole 1-4, the first thick spherical shell liquid guide hole 2-1, the second thick spherical shell liquid guide hole 2-2, the third thick spherical shell liquid guide hole 2-3 and the fourth thick spherical shell liquid guide hole 2-4 and then accumulated in the annular liquid retaining groove 3-5; finally, the brain gray matter equivalent solution is injected into the thin spherical shell 1 until the liquid level reaches four fifths of the height of the interior of the thin spherical shell 1.
Meanwhile, the method for preparing the cerebrospinal fluid equivalent solution and the brain ash equivalent solution takes primary pure water as a basic substance, and adjusts the conductivity and the relative dielectric constant of the tissue equivalent solution by adding salts and saccharides, so that the conductivity and the relative dielectric constant of the two equivalent solutions are respectively equivalent to that of the cerebrospinal fluid and the brain ash of a real human body, wherein the conductivity of the cerebrospinal fluid of the real human body is 1.00-2.51S/m, the relative dielectric constant is 109+/-30, the conductivity of the brain ash of the real human body is 0.06-2.47S/m, and the relative dielectric constant is 85600+/-25000. The relative dielectric constants were all measured and calibrated at a frequency of 2.8 kHz.
Referring to fig. 3C, the first circular through hole 4-1 and the second circular through hole 4-2 are symmetrically etched at both sides of the cross bar 4, the first circular through hole 4-1 is communicated with the first circular side through hole 4-3, the second circular through hole 4-2 is communicated with the second circular side through hole 4-4, threads are arranged inside the first circular side through hole 4-3 and the second circular side through hole 4-4, and the cross bar 4 is screwed through the first circular side through hole 4-3 and the second circular side through hole 4-4 by using screws, so that the cross bar 4 is kept at a fixed height on the threaded rod 5; and etching a second rectangular through hole 4-5 in the middle of the cross bar 4.
Referring to fig. 3A, 3B, 3C and 3D, the threaded rod 5 includes two identical first threaded rods 5-1 and second threaded rods 5-2, threads are provided at the bottom of each threaded rod and can be screwed into any one of the first circular hole array 3-1, the second circular hole array 3-2, the third circular hole array 3-3 and the fourth circular hole array 3-4, and the top diameters of the first threaded rod 5-1 and the second threaded rod 5-2 are slightly smaller than the inner diameters of the first circular through hole 4-1 and the second circular through hole 4-2. The upper end of the first threaded rod 5-1 and the upper end of the second threaded rod 5-2 respectively pass through the first round through hole 4-1 and the second round through hole 4-2, and then respectively pass through the first side round through hole 4-3 and the second side round through hole 4-4 by using plastic screws and are screwed, so that the relative positions of the cross rod 4 and the first threaded rod 5-1 and the second threaded rod 5-2 are fixed; the lower end of the first threaded rod 5-1 is in threaded connection with any round hole in the first round hole array 3-1, the lower end of the second threaded rod 5-2 is in threaded connection with a round hole in the third round hole array 3-3 symmetrical to the round hole connected with the first threaded rod 5-1, and at the moment, a circle center connecting line between the round hole connected with the first threaded rod 5-1 and the round hole connected with the second threaded rod 5-2 is parallel to a circle center connecting line of all round holes in the second round hole array 3-2 and a circle center connecting line of all round holes in the fourth round hole array 3-4; or any round hole in the first threaded rod 5-1 lower end and the second round hole array 3-2 is in threaded connection, the lower end of the second threaded rod 5-2 is in threaded connection with a round hole in the fourth round hole array 3-4 symmetrical to the round hole connected with the lower end of the first threaded rod 5-1, and at the moment, a circle center connecting line between the round hole connected with the first threaded rod 5-1 and the round hole connected with the second threaded rod 5-2 is parallel to a circle center connecting line of all round holes in the first round hole array 3-1 and a circle center connecting line of all round holes in the third round hole array 3-3.
Referring to fig. 3E and 3F, the sliding block 6 is composed of a left sliding block 6-1 and a right sliding block 6-2 which have the same structure and are symmetrical to each other, a rectangular block at the upper half part of the left sliding block 6-1 is drilled with a first symmetrical through hole 6-3 and a second symmetrical through hole 6-4, and a square block at the lower half part of the left sliding block 6-1 is drilled with a first through hole 6-7; the rectangular block at the upper half part of the right sliding block 6-2 is provided with a third symmetrical through hole 6-5 and a fourth symmetrical through hole 6-6 corresponding to the first symmetrical through hole 6-3 and the second symmetrical through hole 6-4, the rectangular block at the lower half part of the right sliding block 6-2 is provided with a second through hole 6-8 corresponding to the first through hole 6-7, and the inner walls of all four symmetrical through holes, the first through hole 6-7 and the second through hole 6-8 are provided with threads; after the left sliding block 6-1 and the right sliding block 6-2 are assembled and combined together, a top through hole 6-9 is drilled on the upper surface of the assembled left sliding block 6-1 and right sliding block 6-2; the lower half part of the sliding block 6 is provided with a T-shaped through hole 6-10, and the cross rod 4 can be embedded into the upper half part of the T-shaped through hole 6-10.
Referring to fig. 4A and 4B, the magnetic field measuring probe 7 includes a probe body 7-1 and a protective housing 7-2, three high precision hall elements are built in the probe body 7-1, the three hall elements are spatially distributed in three dimensions in an orthogonal manner and fixed in the probe body 7-1 in a cuboid shape, and voltage signals generated by the hall elements after the stimulation of an alternating magnetic field are calculated and converted into magnetic field signals by a voltage-magnetic induction intensity conversion formula; the data wire 10 of the device host is connected with three high-precision Hall elements, then penetrates out from the upper part of the probe main body 7-1, and then penetrates through the protective shell 7-2 and then is connected with the device host 9; after the probe main body 7-1 is assembled, the probe main body 7-1 is impregnated with resin rubber to realize waterproof sealing of the Hall element and the circuit board thereof, and the protective shell 7-2 is vertically fixed on the upper surface of the probe main body 7-1; the diameter of the probe main body 7-1 is smaller than that of the second rectangular through hole 4-5, and the outer diameter of the protective shell 7-2 is the same as the inner diameter of the top through hole 6-9; the upper position of the protective shell 7-2 is etched with a positioning wire for positioning during the assembly of the special bracket.
Referring to fig. 1A, 3 and 4A and 4B, the magnetic field measuring probe 7 is installed in the second rectangular through hole 4-5, the left slider 6-1 and the right slider 6-2 sandwich the protective housing 7-2 and align the positioning line on the protective housing 7-2 with the lower surface of the T-shaped through hole 6-10, and the cross bar 4 is embedded in the upper half of the T-shaped through hole 6-10; the plastic screws respectively pass through the first symmetrical through hole 6-3, the third symmetrical through hole 6-5, the second symmetrical through hole 6-4 and the fourth symmetrical through hole 6-6 and are fixed through nuts; the plastic screw is connected with the first through hole 6-7 and the first through hole 6-8 in a threaded manner and screwed, so that the sliding block 6 is fixed on the cross rod 4.
Referring to fig. 1 to 6, a method for detecting magnetic field and temperature of a transcranial magnetic stimulation therapeutic apparatus according to a preferred embodiment of the present utility model mainly comprises the following steps:
firstly, designing and processing a bionic head die body, wherein the bionic head die body is similar to the real human head structure in size, and the tissue electromagnetic characteristics are equivalent under transcranial magnetic stimulation coverage frequency band.
The design of the biomimetic head phantom is shown in fig. 2A-2C. The bionic head die body is similar to the real human head in size, tissue electromagnetic characteristics are equivalent under transcranial magnetic stimulation coverage frequency band, and the die body is light in structure and convenient to assemble and transport.
Referring to FIG. 2B, the thin spherical shell 1 is used as a barrier between the gray matter layer and the cerebrospinal fluid layer, and is required to maintain high hardness and high stability, and consists of a thin spherical shell body 1-5 with a wall thickness of 3mm and an inner diameter of 148mm and a thin spherical shell edge 1-6 with a width of 26mm (including the wall thickness of the thin spherical shell body 1-5). The lower edges of the thin spherical shell edges 1-6 are symmetrically etched at the positions of 0 DEG, 90 DEG, 180 DEG and 270 DEG, wherein the positions of the edges of the thin spherical shell edges close to the positions of the thin spherical shell main body 1-5 are etched with annular grooves 1-7 which are 10mm wide and 10mm deep, wherein the first thin spherical shell edge liquid guide holes 1-1, the second thin spherical shell edge liquid guide holes 1-2, the third thin spherical shell edge liquid guide holes 1-3 and the fourth thin spherical shell edge liquid guide holes 1-4 are respectively formed in the positions of the edges of the thin spherical shell edges 1-6 which are 5mm deep and 5mm wide.
Referring to fig. 2C, the thick spherical shell 2 is used for simulating scalp-skull layer, and is composed of a thick spherical shell body 2-5 with a wall thickness of 12mm and an inner diameter of 160mm and a thick spherical shell edge 2-6 with a width of 20mm (including the wall thickness of the thick spherical shell body 2-5). A first annular protrusion 2-7 having a width of 7mm and a height of 5mm is provided along the upper side of the inner edge of the thick spherical shell body 2-5. And symmetrically etching a first thick spherical shell liquid guide hole 2-1, a second thick spherical shell liquid guide hole 2-2, a third thick spherical shell liquid guide hole 2-3 and a fourth thick spherical shell liquid guide hole 2-4 with the diameters of 10mm at the positions of 0 degree, 90 degree, 180 degree and 270 degree of the first annular bulge 2-7. Four positioning lines are etched at the side surface of the thick spherical shell edge 2-6, the center positions of the first thick spherical shell liquid guide hole 2-1, the second thick spherical shell liquid guide hole 2-2, the third thick spherical shell liquid guide hole 2-3 and the fourth thick spherical shell liquid guide hole 2-4. The outer diameter of the thin spherical shell main body 1-5 is slightly smaller than the inner diameter of the thick spherical shell main body 2-5, the outer diameter of the thin spherical shell edge 1-6 is the same as the outer diameter of the thick spherical shell edge 2-6, the width of the annular bulge 2-7 is smaller than the width of the thick spherical shell edge 2-6, the first annular bulge 2-7 can be embedded into the annular groove 1-7, and the sizes of the first thick spherical shell liquid guide hole 2-1, the second thick spherical shell liquid guide hole 2-2, the third thick spherical shell liquid guide hole 2-3 and the fourth thick spherical shell liquid guide hole 2-4 are the same as the sizes of the first thin spherical shell edge liquid guide hole 1-1, the second thin spherical shell edge liquid guide hole 1-2, the third thin spherical shell edge liquid guide hole 1-3 and the fourth thin spherical shell edge liquid guide hole 1-4. After the cerebrospinal fluid equivalent solution overflows, the cerebrospinal fluid equivalent solution can be respectively guided to the first thin spherical shell liquid guide hole 1-1, the second thin spherical shell liquid guide hole 1-2, the third thin spherical shell liquid guide hole 1-3 and the fourth thin spherical shell liquid guide hole 1-4 through the first thick spherical shell liquid guide hole 2-1, the second thick spherical shell liquid guide hole 2-2, the third thick spherical shell liquid guide hole 2-3 and the fourth thick spherical shell liquid guide hole 2-4.
Fig. 3A-3F are designs of special stents made of nylon materials. The special bracket comprises a base 3, a cross rod 4, a threaded rod 5 and a sliding block 6, and can be used for accurately positioning a bionic head die body, a magnetic field measuring probe and a transcranial magnetic stimulation therapeutic apparatus coil in cooperation with a high-precision steel ruler.
Referring to fig. 3B, the base 3 is an integral structure formed by cutting a cylindrical acrylic nylon substrate with a diameter of 300mm and a height of 170mm, and has no influence on the measurement of magnetic field signals. A cylindrical through hole 3-7 having a diameter of 184mm is etched from the center of the upper surface of the base 3. The depth of the cylindrical through hole 3-7 is larger than the radius of the thick spherical shell body 2-5, and can accommodate the thick spherical shell body 2-5. An annular liquid retaining groove 3-5 with the depth of 10mm and the width of 20mm is etched on the upper surface of the base 3 and is used for containing overflowed cerebrospinal fluid equivalent solution. The annular liquid retaining groove 3-5 and the edge of the upper surface of the base 3 form a second annular bulge 3-6 with the width of 20mm. And a positioning line is symmetrically etched at the positions of 0 DEG, 90 DEG, 180 DEG and 270 DEG on the side surface of the second annular bulge 3-6. And symmetrically etching the first circular hole array 3-1, the second circular hole array 3-2, the third circular hole array 3-3 and the fourth circular hole array 3-4 at the positions of 0 degrees, 90 degrees, 180 degrees and 270 degrees on the upper surface of the base 3, wherein threads are arranged inside all circular holes in each group of circular hole arrays, the inner diameters of the circular holes are 15mm, and the depths of the circular holes are not less than 20mm. The side of the lower part of the base 3 is provided with a first rectangular through hole 3-8 with the width of 200mm and the height of 50mm, and the first rectangular through hole 3-8 and the cylindrical through hole 3-7 form a communicating structure. The lower edge of the first rectangular through hole 3-8 is 20mm from the bottom surface of the base 3.
Referring to fig. 3C, a first circular through hole 4-1 and a second circular through hole 4-2 are symmetrically etched on both sides of the cross bar 4, a first side circular through hole 4-3 and a second side circular through hole 4-4 are vertically etched on the side surface of the cross bar 4, the first circular through hole 4-1 is communicated with the first side circular through hole 4-3, and the second circular through hole 4-2 is communicated with the second side circular through hole 4-4. Threads are arranged inside the first side round through hole 4-3 and the second side round through hole 4-4. A second rectangular through hole 4-5 with the length of 160mm and the width of 16mm is etched in the middle of the cross bar 4, and the second rectangular through hole 4-5 is used for passing through the magnetic field measuring probe 7. The cross bar 4 can pass through the first side round through hole 4-3 and the first side round through hole 4-4 to fix the height by screwing.
Referring to FIG. 3D, the threaded rod 5 comprises two identical first and second threaded rods 5-1 and 5-2, each having a height of 200mm. The bottom of each threaded rod is provided with threads and can be screwed into any round hole of the first round hole array 3-1, the second round hole array 3-2, the third round hole array 3-3 and the fourth round hole array 3-4; the diameters of the first threaded rod 5-1 and the second threaded rod 5-2 are slightly smaller than the inner diameters of the first round through hole 4-1 and the second round through hole 4-2 on the base.
Referring to fig. 3E and 3F, the slider 6 is made of square nylon material, and includes a left slider 6-1 and a right slider 6-2 which have the same structure and are symmetrical to each other, and the left slider 6-1 and the right slider 6-2 are used for fixing the horizontal position of the measuring probe on the cross bar 4. The rectangular block of the upper half part of the left sliding block 6-1 is provided with a first symmetrical through hole 6-3 and a second symmetrical through hole 6-4 in a drilling mode, and the square block of the lower half part of the left sliding block 6-1 is provided with a first through hole 6-7 in a drilling mode; the rectangular block of the upper half part of the right sliding block 6-2 is provided with a third symmetrical through hole 6-5 and a fourth symmetrical through hole 6-6 in a drilling way at the positions corresponding to the first symmetrical through hole 6-3 and the second symmetrical through hole 6-4, the square quick upper part of the lower half part of the right sliding block 6-2 is provided with a second through hole 6-8 and is provided with internal threads, and the inner walls of the first symmetrical through hole 6-3, the second symmetrical through hole 6-4, the third symmetrical through hole 6-6 and the fourth symmetrical through hole 6-7 are provided with threads. The left sliding block 6-1 and the right sliding block 6-2 are assembled and combined together to form the sliding block 6, and a top through hole 6-9 is drilled at the top of the sliding block 6. The lower half part of the sliding block 6 is provided with a T-shaped through hole 6-10, and the nested cross rod 4 can move on the sliding block 6.
As shown in fig. 4A and 4B, the magnetic field measuring probe 7 includes a probe body 7-1 and a protective housing 7-2, the probe body 7-1 having an outer diameter of 14mm, a width of 12mm, a height of 50mm, and a housing thickness of 2mm. Three high-precision Hall elements with close response speed are arranged in the probe main body 7-1, and the probe main body comprises two patch type Hall elements H 1 H and H 2 And one in-line Hall element H 3 .3 Hall elements are distributed in three dimensions in an orthogonal manner in space and are precisely fixed on the probe main body 7-1, wherein the patch Hall element H 1 8mm from the center of the probe body 7-1 inner bottom surface, and a patch Hall element H 2 3mm from the center of the probe body 7-1 to the inner bottom surface of the probe body, and a direct-insertion Hall element H 3 15mm from the inner bottom surface of the probe body 7-1. The data line of the three-dimensional orthogonal Hall element passes through the upper part of the probe main body 7-1, then passes through the protective shell 7-2 and is connected with the device host 9; after the probe body 7-1 is assembled, the probe body 7-1 is impregnated with resin rubber to achieve waterproof sealing of the hall element and its circuit board, and the protective housing 7-2 is vertically fixed to the upper surface of the probe body 7-1. The width of the probe main body 7-1 is slightly smaller than that of the second rectangular through hole 4-5, and the outer diameter of the protective shell 7-2 is communicated with the top of the sliding block 6 The bores 6-9 have the same inner diameter.
In addition, cerebrospinal fluid equivalent solution and brain gray matter equivalent solution were prepared, sodium chloride, potassium chloride and glucose were added to the primary pure water, and the conductivity and relative permittivity thereof were measured at 2.8kHz, respectively. Wherein, the conductivity of the cerebrospinal fluid equivalent solution is 2.01S/m, and the relative dielectric constant is 130; the brain grey matter equivalent solution has conductivity of 0.11S/m and relative dielectric constant of 80500.
And secondly, after the bionic head die body and the special support are assembled, the device host 9 is respectively connected with the magnetic field measuring probe 7 and the temperature measuring module 8 through a data line 10 of the device host, and the power supply of each device is started. The stimulating coil of the transcranial magnetic stimulation therapeutic apparatus is inserted into the first rectangular through hole 3-8 on the base 3, and the center of the coil is tightly attached to and does not squeeze the thick spherical shell main body 2-5. If the stimulation coil cannot be tightly attached, an acrylic plate with proper size can be used for lifting the stimulation coil in the first rectangular through hole 3-8.
Thirdly, setting a stimulation sequence of the transcranial magnetic stimulation therapeutic apparatus, operating special equipment for detecting magnetic fields and temperatures of the transcranial magnetic stimulation therapeutic apparatus to collect and analyze magnetic field signals and temperature signals, and evaluating uncertainty of measurement results.
In another embodiment 2 of the present utility model, the control computer 11 is further included, the control computer 11 is connected with the device host 9 through the data line 10 of the device host, and the control computer 10 controls the data acquisition process and realizes the display, processing and storage of data. Other structures are the same as those of embodiment 1 described above.
In order to better reproduce the contents of the present utility model, the foregoing magnetic field and temperature measurement principles, processes and results are briefly described below.
The hall effect is that when a current I is applied to the hall element, an external magnetic field perpendicular to the current direction causes electrons and holes in the semiconductor that are driven by a voltage to directionally move to collect in different directions and generate an electric field. When the electric field force exerted by the particles moving in a directional manner is balanced with the Lorentz force, electrons and holes are not deflected any more, and the built-in voltage generated by the electric field force is called as Hall voltage U H This can be expressed as:
wherein d is the thickness of the Hall element, I is the current intensity applied in the conductor, B is the magnetic field intensity, R H Is a hall resistor.
According to (1), the magnetic induction intensity B and the Hall voltage U H Linear correlation between them, the magnetic induction intensity can be calculated by the Hall voltage.
Thermoelectric effect refers to a phenomenon in which current or charge builds up as electrons (holes) in a heated object migrate from a high temperature region to a low temperature region with a temperature gradient. The magnitude of this effect is reflected by the thermal energy (Q), defined as:
Where E is the electric field created by charge accumulation and dT is the temperature gradient.
According to equation (2), the temperature gradient generated across the sensor is linearly related to the potential, from which the temperature gradient can be calculated.
The maximum magnetic induction intensity is measured by setting the output frequency of a stimulation sequence of the transcranial magnetic stimulation therapeutic apparatus to be 10Hz, the output intensity to be 100%, the stimulation duration to be 1s and the stimulation cluster interval to be 2s, vertically attaching the magnetic field measuring probe 7 to the surface of the stimulation coil 12 according to the figure 5, measuring the magnetic induction intensity at measuring positions 12-1, 12-2, 12-3 and 12-4 respectively, and repeatedly measuring 6 times at each measuring point (as shown in figure 5).
The magnetic induction intensity of the measurement space point in the utility model means that the output frequency of the stimulation sequence of the transcranial magnetic stimulation therapeutic apparatus is set to be 10Hz, the output intensity is 100%, the stimulation duration is 1s, and the stimulation cluster interval is 2s. According to the measurement points selected in fig. 6, the probe body 7-1 is placed at each measurement point in turn, ensuring that each measurement point is 10mm from the lower surface of the probe body, and each measurement point is repeatedly measured 6 times. The measuring points are 19 spatial measuring points in total of 3 layers in the thin spherical shell main body 1-5, wherein O 'to II' are numbers of layers where the measuring points are located. The 0' layer only contains 1 measuring point, is positioned at the center of the inner bottom surface of the thin spherical shell main body 1-5, and is particularly 10mm at the lowest point inside the thin spherical shell main body 1-5; the distance between the O 'layer and the I' layer and the height difference between the I 'layer and the II' layer are 15mm. The layer I 'and the layer II' contain 9 measuring points, and the plane formed by the measuring points of each layer is parallel to the upper surfaces of the thin spherical shell bodies 1-5. Referring to the coordinate axes in fig. 6, the difference in distance between the measurement points in each row (y-axis direction) of the i 'layer and the ii' layer is 20mm, and the difference in distance between the measurement points in each column (x-axis direction) is 15mm.
Measuring output frequency means that the output frequency of a stimulation sequence of the transcranial magnetic stimulation therapeutic apparatus is set to be 5Hz and 10Hz, the output intensity is 80%, the stimulation duration is 1s, and the stimulation cluster interval is 2s; the output frequency of the stimulation sequence is set to 25Hz, the output intensity is 50%, the stimulation duration is 1s, and the interval time of the stimulation clusters is 2s. Under the above 3 output frequency conditions, the magnetic field signal at each output frequency was measured at the O' point shown in fig. 6 and calculated to obtain an output frequency measurement result, and the measurement was repeated 6 times at each output frequency.
Measuring the stimulation pulse width means that the output frequency of a stimulation sequence of the transcranial magnetic stimulation therapeutic apparatus is set to be 5Hz and 10Hz, the output intensity is 80%, the stimulation duration is 1s, and the stimulation cluster interval time is 2s; the output frequency of the stimulation sequence is set to 25Hz, the output intensity is 50%, the stimulation duration is 1s, and the interval time of the stimulation clusters is 2s. Under the above 3 output frequency conditions, the magnetic field signal at each output frequency was measured at the O' point shown in fig. 6 and the stimulation pulse width measurement result was calculated and obtained, and the measurement was repeated 6 times at each output frequency.
The measurement of the surface temperature of the coil means that the output frequency of the stimulation sequence of the transcranial magnetic stimulation therapeutic apparatus is set to be 10Hz, the output intensity is 100%, the stimulation duration is 1s, and the stimulation cluster interval is 2s. According to fig. 5, the temperature measuring module 8 is attached to the measuring points 12-1, 12-2, 12-3 and 12-4 in several times to measure the coil surface temperature at these points. Each measurement site measures 6 consecutive stimulation sequences and records the data.
Through the steps, the measurement results of the maximum magnetic induction intensity, the spatial magnetic field distribution, the output magnetic field frequency, the output magnetic field stimulation pulse width and the coil surface temperature of the transcranial magnetic stimulation therapeutic apparatus are shown in tables 1-6.
TABLE 1 maximum magnetic induction measurement results (Unit: T) after outliers were removed
TABLE 2 simulation results of maximum magnetic induction (unit: T)
As can be seen from tables 1 and 2, the maximum magnetic induction intensity which can be achieved by the surface of the stimulation coil is 2.227T, which is slightly higher than 2.122T obtained by simulation, the deviation between the simulation and the actual measurement is about 4.71%, the simulation and the actual measurement data are well matched, and the detection device can complete the magnetic induction intensity measurement function in space.
TABLE 3 simulation and comparison of measured values of magnetic induction in a thin spherical shell body
According to table 3, the simulation result is similar to the actual measurement result, and the detection device can complete the measurement function of the magnetic induction intensity in the solution.
Table 4 outputs the frequency measurement results (unit: hz)
According to table 4, the relative deviation between the measurement result of the output frequency of the TMS therapeutic apparatus and the set value is measured to be within 0.60%, and the output frequency of the equipment is stable.
TABLE 5 stimulation pulse width measurement (Unit: μs)
According to Table 5, the actual stimulation pulse width of the TMS therapeutic apparatus was unstable, and the stimulation pulse width did not have a fixed trend of variation with the change of the output frequency. Consult the technical manual of this transcranial magnetic stimulation therapeutic apparatus, its setting value of the stimulation pulse width is 404.56 mus, then the biggest relative deviation of the stimulation pulse width measured value of equipment and setting value is 3.32%. The detection device can complete the function of measuring the stimulus pulse width.
TABLE 6 coil surface temperature measurement results (Unit:. Degree.C.)
According to table 6, temperature measurement module can normally work steadily, and detection device can realize the function of measuring coil surface temperature in real time.
The present utility model is not limited to the above-mentioned embodiments, but is intended to be limited to the following embodiments, and any modifications, equivalents and modifications can be made to the above-mentioned embodiments without departing from the scope of the utility model.
Claims (6)
1. The utility model provides a professional equipment for transcranial magnetic stimulation therapeutic apparatus magnetic field and temperature detection, includes temperature measurement module (8), device host computer (9) and device host computer's data line (10), and device host computer's data line (10) are connected with temperature measurement module (8), its characterized in that: the bionic head die body, the special bracket and the magnetic field measuring probe (7) are also included;
The bionic head die body consists of a thin spherical shell (1) positioned on the upper layer and a thick spherical shell (2) positioned on the lower layer, wherein the thin spherical shell (1) and the thick spherical shell (2) are integrated structures which are respectively made of cylindrical acrylic base materials through cutting, the bionic head die body is arranged on a base (3), a magnetic field measuring probe (7) is arranged at the top of a sliding block (6) of a special bracket, and the magnetic field measuring probe (7) is connected with a device host (9) through a data line (10) of the device host.
2. A special device for transcranial magnetic stimulation therapeutic magnetic field and temperature detection according to claim 1, wherein: the thin spherical shell (1) consists of a thin spherical shell main body (1-5) and a thin spherical shell edge (1-6), wherein the thin spherical shell main body (1-5) is a hemisphere with the wall thickness not exceeding 3mm and the inner diameter of 140-150 mm, a first thin spherical shell liquid guide hole (1-1), a second thin spherical shell liquid guide hole (1-2), a third thin spherical shell liquid guide hole (1-3) and a fourth thin spherical shell liquid guide hole (1-4) are respectively and symmetrically etched at the positions of 0 DEG, 90 DEG, 180 DEG and 270 DEG on the lower edge of the thin spherical shell edge (1-6), and an annular groove (1-7) is etched at the position, close to the thin spherical shell main body (1-5), of the lower edge of the thin spherical shell edge (1-6); the thick spherical shell (2) consists of a thick spherical shell main body (2-5) and a thick spherical shell edge (2-6), wherein the thick spherical shell main body (2-5) is a semi-spherical shell with the wall thickness not exceeding 12mm and the inner diameter of 150-165 mm, a first annular bulge (2-7) is arranged above the thick spherical shell edge (2-6) and along the inner edge of the thick spherical shell main body (2-5), a first thick spherical shell liquid guide hole (2-1), a second thick spherical shell liquid guide hole (2-2), a third thick spherical shell liquid guide hole (2-3) and a fourth thick spherical shell liquid guide hole (2-4) are respectively and symmetrically etched at 0 DEG, 90 DEG, 180 DEG and 270 DEG of the first annular bulge (2-7), the second thick spherical shell liquid guide hole (2-3) and the fourth thick spherical shell liquid guide hole (2-4), the first spherical shell liquid guide hole (2-1), the third thick spherical shell liquid guide hole (2-3) and the fourth spherical shell liquid guide hole (2-4) are respectively and symmetrically etched at the positions of the first thick spherical shell liquid guide hole (2-1), the third thick spherical shell liquid guide hole (2-3) and the fourth spherical shell liquid guide hole (2-6), and the first spherical shell liquid guide hole (2-3-4), the fourth spherical shell liquid guide hole (2-3, the fourth spherical shell liquid guide hole (2-3, and the fourth spherical shell liquid guide hole (7 The second thin spherical shell liquid guide holes (1-2), the third thin spherical shell liquid guide holes (1-3) and the fourth thin spherical shell liquid guide holes (1-4) are in one-to-one correspondence and have the same diameter.
3. A special device for transcranial magnetic stimulation therapeutic magnetic field and temperature detection according to claim 1, wherein: the special bracket is made of nylon base material through cutting, and consists of a base (3), a cross rod (4), a threaded rod (5) and a sliding block (6);
the upper surface of the base (3) is internally etched to form a cylindrical through hole (3-7), the inner diameter of the cylindrical through hole (3-7) is larger than the outer diameter of the thick spherical shell main body (2-5), and the depth of the cylindrical through hole (3-7) is larger than that of the thick spherical shell
The radius of the main body (2-5) is that an annular liquid retaining groove (3-5) is etched on the upper surface of the base (3), a second annular bulge (3-6) is formed between the annular liquid retaining groove (3-5) and the cylindrical through hole (3-7) at the rest part, and the angles of 0 DEG, 90 DEG, 180 DEG and 270 DEG are formed on the outer side surface of the second annular bulge (3-6)
Symmetrically etching a positioning line at each position; the method comprises the steps that four groups of first round hole arrays (3-1), second round hole arrays (3-2), third round hole arrays (3-3) and fourth round hole arrays (3-4) with the same inner diameter are symmetrically etched at the positions, which are close to the outer side area, of the upper surface of a base (3) and are 0 degrees, 90 degrees, 180 degrees and 270 degrees, each group of round hole arrays comprises 3 round holes with the same inner diameter and threads arranged in the inner part, and the circle center connecting line distances of adjacent round holes in each group of round hole arrays are the same; a first rectangular through hole (3-8) is formed in the side face of the lower part of the base (3), the first rectangular through hole (3-8) and the cylindrical through hole (3-7) form a communication structure, the width of the first rectangular through hole (3-8) is not smaller than 200mm, the height of the first rectangular through hole is not smaller than 50mm, and the distance between the lower edge of the first rectangular through hole (3-8) and the bottom face of the base (3) is not smaller than 20mm;
The two sides of the cross rod (4) are symmetrically etched with a first round through hole (4-1) and a second round through hole (4-2), the side surface of the cross rod (4) is vertically etched with a first side round through hole (4-3) and a second side round through hole (4-4), the first round through hole (4-1) is communicated with the first side round through hole (4-3), and the second round through hole (4-2) is communicated with the second side round through hole (4-4); threads are arranged in the first side round through hole (4-3) and the second side round through hole (4-4), and screws penetrate through the first side round through hole (4-3) and the second side round through hole (4-4) and are screwed, so that the cross rod (4) is kept at a fixed height on the threaded rod (5); etching a second rectangular through hole (4-5) in the middle of the cross rod (4);
the threaded rod (5) comprises two identical first threaded rods (5-1) and second threaded rods (5-2), threads are arranged at the bottom of each threaded rod and can be screwed into any one of the first round hole array (3-1), the second round hole array (3-2), the third round hole array (3-3) and the fourth round hole array (3-4), and the top diameters of the first threaded rods (5-1) and the second threaded rods (5-2) are smaller than the inner diameters of the first round through holes (4-1) and the second round through holes (4-2);
the sliding block (6) consists of a left sliding block (6-1) and a right sliding block (6-2) which are identical in structure and symmetrical to each other, a first symmetrical through hole (6-3) and a second symmetrical through hole (6-4) are drilled on a rectangular block at the upper half part of the left sliding block (6-1), and a first through hole (6-7) is drilled on a square block at the lower half part of the left sliding block (6-1); the rectangular block at the upper half part of the right sliding block (6-2) is provided with a third symmetrical through hole (6-5) and a fourth symmetrical through hole (6-6) corresponding to the first symmetrical through hole (6-3) and the second symmetrical through hole (6-4), the square block at the lower half part of the right sliding block (6-2) is provided with a second through hole (6-8) corresponding to the first through hole (6-7), and the inner walls of all four symmetrical through holes, the first through hole (6-7) and the second through hole (6-8) are provided with threads;
The upper surface of the left sliding block (6-1) and the right sliding block (6-2) which are assembled into a whole is provided with a top through hole (6-9);
the lower half part of the sliding block (6) is provided with a T-shaped through hole (6-10), and the cross rod (4) can be embedded into the upper half part of the T-shaped through hole (6-10);
the upper end of the first threaded rod (5-1) and the upper end of the second threaded rod (5-2) respectively penetrate through the first round through hole (4-1) and the second round through hole (4-2), and then plastic screws respectively penetrate through the first side round through hole (4-3) and the second side round through hole (4-4) and are screwed, so that the relative positions of the cross rod (4) and the first threaded rod (5-1) and the second threaded rod (5-2) are fixed; the lower end of the first threaded rod (5-1) is in threaded connection with any round hole in the first round hole array (3-1), the lower end of the second threaded rod (5-2) is in threaded connection with round holes in the third round hole array (3-3) which are symmetrical to round holes connected with the first threaded rod (5-1), and a circle center connecting line between the round holes connected with the first threaded rod (5-1) and the round holes connected with the second threaded rod (5-2) is parallel to all circle center connecting lines of round holes in the second round hole array (3-2) and all circle center connecting lines of round holes in the fourth round hole array (3-4);
or any round hole in the lower end of the first threaded rod (5-1) and the second round hole array (3-2) is in threaded connection, the lower end of the second threaded rod (5-2) is in threaded connection with a round hole in the fourth round hole array (3-4) which is symmetrical to the round hole connected with the lower end of the first threaded rod (5-1), and at the moment, the circle center connecting line between the round hole connected with the first threaded rod (5-1) and the round hole connected with the second threaded rod (5-2) is parallel to the circle center connecting line of all round holes in the first round hole array (3-1) and the circle center connecting line of all round holes in the third round hole array (3-3).
4. The special device for detecting the magnetic field and the temperature of the transcranial magnetic stimulation therapeutic apparatus according to claim 1, wherein the special device comprises the following components: the cerebrospinal fluid equivalent solution is injected into the thick spherical shell (2), the liquid level of the cerebrospinal fluid equivalent solution reaches one third of the inner height of the thick spherical shell (2), and when Bao Qiuke (1) is placed into the thick spherical shell (2), the excessive injected cerebrospinal fluid equivalent solution is accumulated in the annular liquid retaining groove (3-5);
and injecting the brain ash equivalent solution into the thin spherical shell (1), wherein the liquid level of the brain ash equivalent solution reaches four fifths of the height of the inside of the thin spherical shell (1).
5. A special device for magnetic field and temperature detection of transcranial magnetic stimulation therapeutic apparatus according to claim 1 or 3, wherein: the magnetic field measurement probe (7) comprises a probe main body (7-1) and a protective shell (7-2), three high-precision Hall elements are arranged in the probe main body (7-1), the three Hall elements are distributed in a three-dimensional orthogonal mode in space and fixed in the cuboid-shaped probe main body (7-1), and the Hall elements generate voltage signals after being stimulated by an alternating magnetic field and are converted into magnetic field signals; the data wire (10) of the device host is connected with the three high-precision Hall elements, then penetrates out from the upper part of the probe main body (7-1), penetrates through the protective shell (7-2) and then is connected with the device host (9); after the probe main body (7-1) is assembled, the probe main body (7-1) is impregnated with resin rubber to realize waterproof sealing of the Hall element and the circuit board thereof, and meanwhile, the protective shell (7-2) is vertically fixed on the upper surface of the probe main body (7-1); the diameter of the probe main body (7-1) is smaller than that of the second rectangular through hole (4-5), the outer diameter of the protective shell (7-2) is the same as the inner diameter of the top through hole (6-9), and a positioning wire is etched at the upper position of the protective shell (7-2) and used for positioning during the assembly of the special bracket;
The magnetic field measuring probe (7) is arranged in the second rectangular through hole (4-5), the left sliding block (6-1) and the right sliding block (6-2) clamp the protective shell (7-2) and enable a positioning line on the protective shell (7-2) to be aligned with the lower surface of the T-shaped through hole (6-10), and the cross rod (4) is embedded into the upper half part of the T-shaped through hole (6-10);
the plastic screws respectively pass through the first symmetrical through hole (6-3) and the third symmetrical through hole (6-5), the second symmetrical through hole (6-4) and the fourth symmetrical through hole (6-6) and are fixed through nuts; the plastic screw is in threaded connection with the first through hole (6-7) and the second through hole (6-8) and screwed, so that the sliding block (6) is fixed on the cross rod (4).
6. The special device for detecting the magnetic field and the temperature of the transcranial magnetic stimulation therapeutic apparatus according to claim 5, wherein the special device comprises the following components: the temperature measuring module (8) comprises a platinum resistance temperature sensor, and a signal generated by the platinum resistance sensor is transmitted to the device host (9) through a data line (10) of the device host; a virtual oscilloscope module is arranged in the device host (9) to realize the processing and storage of voltage signals generated by the Hall element in the probe main body (7-1) and voltage signals generated by the temperature measuring module.
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