CN105561279A - Qi and spleen tonifying and liver soothing granules for treating spleen deficiency and liver stagnation type ulcerative colitis - Google Patents

Qi and spleen tonifying and liver soothing granules for treating spleen deficiency and liver stagnation type ulcerative colitis Download PDF

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CN105561279A
CN105561279A CN201610085490.9A CN201610085490A CN105561279A CN 105561279 A CN105561279 A CN 105561279A CN 201610085490 A CN201610085490 A CN 201610085490A CN 105561279 A CN105561279 A CN 105561279A
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radix
liver
spleen
rhizoma
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陈旭
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/285—Aucklandia
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708—Rheum (rhubarb)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction

Abstract

The invention discloses qi and spleen tonifying and liver soothing granules for treating spleen deficiency and liver stagnation type ulcerative colitis. The qi and spleen tonifying and liver soothing granules are prepared from, by weight, 10-15 parts of astragalus membranaceus, 10-13 parts of codonopsis pilosula, 8-10 parts of the roots of red-rooted salvia, 8-10 parts of pericarpium citri reticulatae, 10-13 parts of radix bupleuri, 25-30 parts of radix paeoniae alba, 10-13 parts of fruits of immature citron, 8-10 parts of coptis chinensis, 8-10 parts of baked ginger, 5-8 parts of radix aucklandiae and 4-6 parts of radix glycyrrhizae. The qi and spleen tonifying and liver soothing granules have the advantages of being short in treatment course, small in side effect and capable of inhibiting intestine mucosa injuries, adjusting intestinal microecology, correcting colon dynamic disorder, achieving multi-link, multidirectional and multi-target comprehensive treatment on the whole, and achieving the effects of improving the life quality of a patient, increasing the curative rate, lowering the recurrence rate and reducing adverse reactions.

Description

The replenishing QI to invigorate the spleen liver-soothing granules for the treatment of spleen liver depression-type ulcerative colitis
Technical field:
The present invention relates to a kind of replenishing QI to invigorate the spleen liver-soothing granules for the treatment of spleen liver depression-type ulcerative colitis, belong to medical art.
Background technology:
Spleen liver depression-type chronic ulcerative colitis is a kind of agnogenic chronic colitis, and be digestive system common disease, its pathological changes is mainly positioned at the mucous layer of colon, involves rectum and lower distal colon more, but can proximally expand, so that throughout whole colon.Cardinal symptom has diarrhoea, bloody purulent stool, stomachache and tenesmus.This course of disease is very long, and state of an illness weight differs, normal recurrent exerbation.Some recurrent exerbation can cause canceration.There is no effective Therapeutic Method at present, western medical treatment side effect is large, and the course for the treatment of is long, and method and the medicine of therefore inquiring into treatment chronic ulcerative colitis have important clinical meaning.
Ulcerative colitis, also known as chronic non-specific ulcerative colitis, is that a kind of reason of rectum and colon site is not bright, but the inflammatory bowel relevant with autoimmune.Pathological changes is mainly positioned at the mucous layer of colon, and based on ulcer, involves rectum and lower distal colon more, but can proximally expand, so that throughout whole colon.Clinical main manifestations is the symptom such as diarrhoea, mucus bloody purulent stool, stomachache and tenesmus.In recent years, due to the change of dietary structure and the quickening of rhythm of life, its sickness rate is in ascendant trend year by year, and this course of disease is very long, and state of an illness weight differs, normal recurrent exerbation.
Summary of the invention:
In view of this, the object of this invention is to provide a kind of replenishing QI to invigorate the spleen liver-soothing granules for the treatment of spleen liver depression-type ulcerative colitis.
For achieving the above object, the technical solution used in the present invention is:
Treat a replenishing QI to invigorate the spleen liver-soothing granules for spleen liver depression-type ulcerative colitis, be made up of the raw material of following weight portion:
Radix Astragali 10-15 part, Radix Codonopsis 10-13 part, Radix Salviae Miltiorrhizae 8-10 part, Pericarpium Citri Reticulatae 8-10 part, Radix Bupleuri 10-13 part, Radix Paeoniae Alba 25-30 part, Fructus Aurantii Immaturus 10-13 part, Rhizoma Coptidis 8-10 part, Rhizoma Zingiberis Preparatum 8-10 part, Radix Aucklandiae 5-8 part, Rhizoma Atractylodis Macrocephalae (parched) 25-30 part, Radix Et Rhizoma Rhei 5-10 part, Fructus Mume 10-15 part, Herba Portulacae 12-15 part, Radix Glycyrrhizae 4-6 part.
Optimum weight part of Chinese medicine preparation crude drug of the present invention is: the Radix Astragali 12 parts, Radix Codonopsis 12 parts, Radix Salviae Miltiorrhizae 10 parts, Pericarpium Citri Reticulatae 10 parts, Radix Bupleuri 12 parts, the Radix Paeoniae Alba 30 parts, Fructus Aurantii Immaturus 12 parts, Rhizoma Coptidis 9 parts, Rhizoma Zingiberis Preparatum 9 parts, the Radix Aucklandiae 6 parts, Rhizoma Atractylodis Macrocephalae (parched) 30 parts, Radix Et Rhizoma Rhei 10 parts, Fructus Mume 12 parts, Herba Portulacae 15 parts, 5 parts, Radix Glycyrrhizae.
The pharmacological action of Chinese medicine of the present invention is as follows:
Radix Bupleuri, the Radix Astragali are monarch drug altogether, and Radix Bupleuri enters liver and gall warp, and pungent row hardship is let out, and the gas of the clear sun of elevate a turnable ladder taste, expelling pathogenic factors from the exterior is gone out, preventing the attack (or recurrence) of malaria of bringing down a fever, and dispersing the stagnated live-QI to relieve the stagnation of QI disperses the gas of edema with the liver involved stasis, and irritability must be dredged, and catharsis must be answered, and does not take advantage of temper.The Radix Astragali, sugariness, tepor, returns spleen channel, is apt to into taste, is the first key medicine of invigorating the spleen and replenishing QI.Can spleen invigorating invigorating middle warmer, the gas of the clear sun of elevate a turnable ladder taste, QI invigorating also can hemopoietic, has promoting tissue regeneration and ulcer healing, the use of promoting pus discharge and tissue regeneration strengthening.Shennong's Herbal: " cure mainly carbuncle, lose skin ulcer for a long time, evacuation of pus is pain ... tonify deficiency." two medicines share, long memorial reaches irritability, invigorating the spleen and benefiting QI altogether, mends native under-stocking, and treating disease basic, is monarch drug altogether.
Fructus Aurantii Immaturus, the Radix Paeoniae Alba, Rhizoma Coptidis, Rhizoma Atractylodis Macrocephalae (parched), the Radix Aucklandiae, Herba Portulacae, Radix Et Rhizoma Rhei are ministerial drug altogether.Fructus Aurantii Immaturus is bitter, pungent, warm, returns spleen, stomach, large intestine channel, and the broken knot of kind resolving depression of regulating the flow of vital energy, associate with Radix Bupleuri, one rise and one drop, strengthens the merit of happy mechanism of qi, with the effect of playing ascending the clear and descending the turbid.The Radix Paeoniae Alba is bitter, acid, be slightly cold, and returns liver, spleen channel.Nourish blood yin fluid astringing, easing the affected liver to relieve pain, and moderate pulse on YING position is anxious, " only heavy after dysentery stomachache " (Compendium of Material Medica).Fructus Aurantii Immaturus and Radix Paeoniae match, and are apt to regulate the flow of vital energy and blood, and QI and blood is in harmonious proportion.Rhizoma Coptidis, bitter, cold, return spleen, stomach, gallbladder, large intestine channel.Bitter wet with dry the intestines and stomach, cold with the heat of bowel relieving stomach, function relatively in burnt, can bowel relieving stomach damp and hot.Shennong's Herbal: " main steam ophthalmalgia, the corner of the eyes hinders delacrimation, spouting bleeding from anus stomachache dysentery." Rhizoma Atractylodis Macrocephalae (parched), sweet, bitter, temperature, returns spleen, stomach warp.With spleen invigorating, dampness for Main Function, be described as " spleen air making-up and spleen enlivening first key medicine " by forefathers.The stir-fry Rhizoma Atractylodis Macrocephalae, the power of invigorating the spleen and benefiting QI is strengthened, also can dampness diuresis.The Radix Aucklandiae, pungent, bitter, temperature, returns spleen, stomach, large intestine, three burnt, gallbladder meridians.With circulation of qi promoting intestinal stasis relieving, strong strengthening the spleen stomach.Be " regulating QI then weighs the reason from removing afterwards "." book on Chinese herbal medicine is looked for the truth ": " Radix Aucklandiae, therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO are three burnt edema caused by disorder of QI key medicines." Herba Portulacae, sour, cold, return liver, large intestine channel, acid is to hold back liver, and the moon of nourishing the liver is with easing the affected liver.Tremble with fear with heat-clearing and toxic substances removing with dysentery relieving.Enter Liver Channel blood system, have clearing away heat and cooling blood, the use of astringing to arrest bleeding, as Compendium of Material Medica " loose blood detumescence, sharp intestinal ... ".Six medicines share, altogether long memorial liver spleen, and dampness heat clearing away, the merit that promoting the circulation of blood is regulated the flow of vital energy is ministerial drug altogether.Radix Et Rhizoma Rhei has immunoregulation, anti-inflammation, improves the effects such as microcirculation; Radix Et Rhizoma Rhei is decocted for a long time, and without rushing down purgation, Radix Et Rhizoma Rhei has heat and toxic materials clearing away, clearing away heat-fire, and removing toxic substances is invigorated blood circulation, and blood stasis dispelling is dispelled and amassed the effect of grade, positive so-called " the six hollow viscera must keep its unobstructed " of use, " general rule is not bitterly "; Herein Radix Et Rhizoma Rhei not afterwards under, with other medicines with decocting, rush down lower composition and be destroyed more, mainly get its dispel long-pending removing toxic substances, blood circulation promoting and blood stasis dispelling, putrefaction-removing granulation-promoting, pathogen must be gone, be just so incensed that the effect of peace, and decoct Radix Et Rhizoma Rhei for a long time and have anti-diarrhea effect.
Rhizoma Zingiberis Preparatum, Fructus Mume are adjuvant drug.Bitter, puckery, temperature, returns spleen, Liver Channel.Blood system is apt to away by Rhizoma Zingiberis Preparatum, is longer than warming the meridian and stops blooding, warming the meridian for stopping bleeding, warming middle-JIAO to relieve pain, also anti-bitter cold can lose taste yang-energy." Elementary Medicine ": " warming the spleen stomach, controls interior cold water and let out, and dysentery intestinal is swum, chronic malaria, cholera, trusted subordinate's cold type of pain distending pain ... dysentery." Fructus Mume, sour, puckery, flat, return liver, spleen, large intestine channel, be usually used in chronic diarrhea chronic dysentery, with sour astringent therapy dysentery.It is too cold and cool that two medicines share Wen Erfang, warming middle-JIAO relieving diarrhea with astringents, is adjuvant drug altogether.
The property of Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, for making medicine.Radix Glycyrrhizae sweet in the mouth, property is put down, still can invigoration spleen qi, sweet can relieving spasm to stop pain." book on Chinese herbal medicine converges and says ": " with middle QI invigorating, the medicine of tonify deficiency removing toxic substances also.”
Replenishing QI to invigorate the spleen liver-soothing granules of the present invention can adopt galenic pharmacy conventional method to make granule by above-mentioned formula: get formula material, decoct, filter, get filtrate concentrating, add adjuvant, make granule.
Advantage of the present invention is: short treating period, and side effect is little, intestinal mucosa can be suppressed to damage, regulating intestinal canal Tiny ecosystem, corrects colonic motor disorder, on the whole the complete treatment of too many levels, multi-faceted, Mutiple Targets.Have and improve patients ' life quality, improve cure rate, reduce relapse rate, reduce effect of untoward reaction.
Detailed description of the invention:
In order to make those skilled in the art understand technical scheme of the present invention better, below in conjunction with specific embodiment, the present invention is described in further detail.
Below in conjunction with embodiment, the specific embodiment of the present invention is further described.Following examples only for technical scheme of the present invention is clearly described, and can not limit the scope of the invention with this.
Embodiment 1
Treat a replenishing QI to invigorate the spleen liver-soothing granules for spleen liver depression-type ulcerative colitis, be made up of the raw material of following weight portion:
The Radix Astragali 12 parts, Radix Codonopsis 12 parts, Radix Salviae Miltiorrhizae 10 parts, Pericarpium Citri Reticulatae 10 parts, Radix Bupleuri 12 parts, the Radix Paeoniae Alba 30 parts, Fructus Aurantii Immaturus 12 parts, Rhizoma Coptidis 9 parts, Rhizoma Zingiberis Preparatum 9 parts, the Radix Aucklandiae 6 parts, Rhizoma Atractylodis Macrocephalae (parched) 30 parts, Radix Et Rhizoma Rhei 10 parts, Fructus Mume 12 parts, Herba Portulacae 15 parts, 5 parts, Radix Glycyrrhizae.
Embodiment 2
Treat a replenishing QI to invigorate the spleen liver-soothing granules for spleen liver depression-type ulcerative colitis, be made up of the raw material of following weight portion:
The Radix Astragali 10 parts, Radix Codonopsis 10 parts, Radix Salviae Miltiorrhizae 9 parts, Pericarpium Citri Reticulatae 9 parts, Radix Bupleuri 13 parts, the Radix Paeoniae Alba 28 parts, Fructus Aurantii Immaturus 13 parts, Rhizoma Coptidis 8 parts, Rhizoma Zingiberis Preparatum 8 parts, the Radix Aucklandiae 5 parts, Rhizoma Atractylodis Macrocephalae (parched) 30 parts, Radix Et Rhizoma Rhei 6 parts, Fructus Mume 13 parts, Herba Portulacae 14 parts, 4 parts, Radix Glycyrrhizae.
Embodiment 3
Treat a replenishing QI to invigorate the spleen liver-soothing granules for spleen liver depression-type ulcerative colitis, be made up of the raw material of following weight portion:
The Radix Astragali 11 parts, Radix Codonopsis 13 parts, Radix Salviae Miltiorrhizae 8 parts, Pericarpium Citri Reticulatae 8 parts, Radix Bupleuri 11 parts, the Radix Paeoniae Alba 27 parts, Fructus Aurantii Immaturus 11 parts, Rhizoma Coptidis 8 parts, Rhizoma Zingiberis Preparatum 10 parts, the Radix Aucklandiae 8 parts, Rhizoma Atractylodis Macrocephalae (parched) 28 parts, Radix Et Rhizoma Rhei 8 parts, Fructus Mume 11 parts, Herba Portulacae 14 parts, 6 parts, Radix Glycyrrhizae.
Clinical research technical report shows, the random packet method of employing, before treatment by analyzing the age, sex, state of an illness mobility, SDS scale standard scores, SAS scale standard grade aspect, two groups of front there was no significant differences for the treatment of, have comparability.In clinical symptoms improvement, in the improvement of abdominal pain, diarrhoea, Nervous and Mental Factors, tcm symptom total mark etc., test group obviously will be better than matched group.Scale standard scores, two groups of Therapeutic Method all obtain promising result, and improve on depressive state and SDS scale standard scores, test group has a clear superiority in, and improving on anxiety state and SAS scale standard scores, two groups do not embody significant difference.Performance and tissue pathologies change under intestinal mirror, test group is being improved under intestinal mirror in mucosa change, erosion or ulcer, and comparatively matched group has a clear superiority in, and two groups of pseudopolyp formation under treatment intestinal mirror, colon bags do not obtain satisfactory effect on changing; Test group embodies clear superiority improving in inflammatory cell infiltration, ulcer comparatively matched group, improving in cryptitis, two groups do not show significant difference, and in treatment crypts epithelial proliferation, goblet cell minimizing, two groups all do not obtain satisfactory effect.
Safety aspect, the coherence checks such as the routine blood test before and after test group, treatment of control group, liver function, kidney merit, do not find significantly abnormal, illustrate that the Therapeutic Method of two groups is safe and reliable, in symptom, the accidental uneasiness of matched group, constipation and sleep change, but do not have significant difference compared to test group, supposition may be because observed case load is less, and test group does not embody the advantage significantly reducing untoward reaction.

Claims (2)

1. treat a replenishing QI to invigorate the spleen liver-soothing granules for spleen liver depression-type ulcerative colitis, it is characterized in that, be made up of the raw material of following weight portion: Radix Astragali 10-15 part, Radix Codonopsis 10-13 part, Radix Salviae Miltiorrhizae 8-10 part, Pericarpium Citri Reticulatae 8-10 part, Radix Bupleuri 10-13 part, Radix Paeoniae Alba 25-30 part, Fructus Aurantii Immaturus 10-13 part, Rhizoma Coptidis 8-10 part, Rhizoma Zingiberis Preparatum 8-10 part, Radix Aucklandiae 5-8 part, Rhizoma Atractylodis Macrocephalae (parched) 25-30 part, Radix Et Rhizoma Rhei 5-10 part, Fructus Mume 10-15 part, Herba Portulacae 12-15 part, Radix Glycyrrhizae 4-6 part.
2. treat a replenishing QI to invigorate the spleen liver-soothing granules for spleen liver depression-type ulcerative colitis, it is characterized in that, be made up of the raw material of following weight portion: the Radix Astragali 12 parts, Radix Codonopsis 12 parts, Radix Salviae Miltiorrhizae 10 parts, Pericarpium Citri Reticulatae 10 parts, Radix Bupleuri 12 parts, the Radix Paeoniae Alba 30 parts, Fructus Aurantii Immaturus 12 parts, Rhizoma Coptidis 9 parts, Rhizoma Zingiberis Preparatum 9 parts, the Radix Aucklandiae 6 parts, Rhizoma Atractylodis Macrocephalae (parched) 30 parts, Radix Et Rhizoma Rhei 10 parts, Fructus Mume 12 parts, Herba Portulacae 15 parts, 5 parts, Radix Glycyrrhizae.
CN201610085490.9A 2016-01-31 2016-01-31 Qi and spleen tonifying and liver soothing granules for treating spleen deficiency and liver stagnation type ulcerative colitis Pending CN105561279A (en)

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Citations (2)

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CN104189794A (en) * 2014-07-26 2014-12-10 王建春 Traditional Chinese medicine used for treating colitis
CN104208230A (en) * 2014-09-26 2014-12-17 禤燕华 Chinese medicinal composition for treating chronic colitis

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104189794A (en) * 2014-07-26 2014-12-10 王建春 Traditional Chinese medicine used for treating colitis
CN104208230A (en) * 2014-09-26 2014-12-17 禤燕华 Chinese medicinal composition for treating chronic colitis

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