CN105561039A - 一种治疗肾结石的中药组合物 - Google Patents
一种治疗肾结石的中药组合物 Download PDFInfo
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Abstract
本发明涉及一种治疗肾结石的中药组合物,它包含下列重量份的物质:生地5-15份、杭芍3-15份、当归3-12份、川芎5-15份、山药5-20份、枣皮3-15份、丹皮9-15份、泽泻3-10份、云芩3-15份、川牛膝3-15份、薏苡仁3-30份、杜仲10-20份、川断3-12份、丹参3-15份、香附3-10份、玄胡3-15份、鸡内金3-10份、海金沙3-20份、金钱草3-30份、木通3-10份、滑石10-20份、车前草10-20份、王不留行5-15份、炒山楂1-15份、白茅根20-50份。本发明的药物的各组分配伍合理,具有清热除湿,利水通淋,泻热降火,活血止痛,破气散结,化石排石的功效,适用于治疗泌尿系统结石,尤其是治疗肾结石具有很好的效果。具有标本兼治,疗效显著,无毒副作用的效果。
Description
技术领域
本发明涉及医药领域,具体来说涉及一种治疗肾结石的中药组合物。
背景技术
肾结石,顾名思义,就是肾脏里面长出了“石头”。在泌尿系统的各个器官中,肾脏通常是结石形成的部位。肾结石是泌尿系统的常见疾病之一,每20个人中,就有一个可能会患肾结石。已知的肾结石成分有数十种。临床上通常把结石分为四大类:含钙结石、感染性结石、尿酸结石和胱氨酸结石。肾结石的病因很多,有遗传性因素、代谢性因素、感染性因素、环境因素、饮食因素、解剖因素、药物因素等等,其发病机制也非常复杂。
发明内容
本发明的目的是提供一种治疗肾结石的中药组合物。
为了实现本发明的目的,本发明提供一种治疗肾结石的中药组合物,它包含下列重量份的物质:生地5-15份、杭芍3-15份、当归3-12份、川芎5-15份、山药5-20份、枣皮3-15份、丹皮9-15份、泽泻3-10份、云芩3-15份、川牛膝3-15份、薏苡仁3-30份、杜仲10-20份、川断3-12份、丹参3-15份、香附3-10份、玄胡3-15份、鸡内金3-10份、海金沙3-20份、金钱草3-30份、木通3-10份、滑石10-20份、车前草10-20份、王不留行5-15份、炒山楂1-15份、白茅根20-50份。
优选地,本发明所述的治疗肾结石的中药组合物包含下列重量份的物质:生地10份、杭芍8份、当归6份、川芎10份、山药10份、枣皮10份、丹皮12份、泽泻8份、云芩10份、川牛膝10份、薏苡仁20份、杜仲15份、川断10份、丹参10份、香附8份、玄胡10份、鸡内金8份、海金沙10份、金钱草20份、木通8份、滑石15份、车前草15份、王不留行10份、炒山楂10份、白茅根30份。
更优选地,本发明所述的治疗肾结石的中药组合物还包含下列重量份的物质:0.1份的具有下列结构式的物质:
最优选地,所述中药组合物可以是洗剂、软膏剂或粉剂。
本发明还提供具有下列结构式的物质在制备治疗肾结石的药物中的用途:
本发明的药物的各组分配伍合理,具有清热除湿,利水通淋,泻热降火,活血止痛,破气散结,化石排石的功效,适用于治疗泌尿系统结石,尤其是治疗肾结石具有很好的效果。具有标本兼治,疗效显著,无毒副作用的效果。
具体实施方式
下面通过实施例进一步说明本发明。应该理解的是,本发明的实施例是用于说明本发明而不是对本发明的限制。根据本发明的实质对本发明进行的简单改进都属于本发明要求保护的范围。除非另有说明,否则本发明中的百分数是重量百分数。
实施例1
称取生地10克、杭芍8克、当归6克、川芎10克、山药10克、枣皮10克、丹皮12克、泽泻8克、云芩10克、川牛膝10克、薏苡仁20克、杜仲15克、川断10克、丹参10克、香附8克、玄胡10克、鸡内金8克、海金沙10克、金钱草20克、木通8克、滑石15克、车前草15克、王不留行10克、炒山楂10克、白茅根30克,粉碎,过100目筛即得。
实施例2
化合物具有下列结构式:
试验例
取SD大鼠(清洁级,体重180-220g,雄性)60只,于清洁级环境中适应性饲养。1周后随机均分为6组,每组10只,分别为正常对照组、模型对照组、阳性药(排石颗粒,南京同仁堂药业有限责任公司)组、给药组1、给药组2和给药组3。除正常对照组每天灌胃给予蒸馏水10ml/kg外,其余5组人鼠造模,每天均用含1体积%乙醇的冷开水作为饮用水,另用2重量%氯化铵水溶液按2ml/只来灌胃。
造模后第3天开始给药,各组给药量如下:正常组与模型组,给予生理盐水灌胃1mL/100g体重;阳性药组,排石颗粒10g加1000mL生理盐水配制成混悬液,给予灌胃1mL/100g体重;给药组1,实施例的粉末10g加1000mL生理盐水配制成混悬液,给予灌胃1mL/100g体重;给药组2,0.02g的化合物加1000mL生理盐水配制成混悬液,给予灌胃1mL/100g体重;给药组3,实施例的粉末5g和0.01g的化合物加1000mL生理盐水配制成混悬液,给予灌胃1mL/100g体重。1次/日,连续给药4周。
末次给药1h后,大鼠采血,离心取上层血清用于测定:二乙酸-肟比色法测血清尿素氮(BUN)水平。
组别 | BUN(mmol·L-1) |
正常组 | 5.56±1.36 |
模型组 | 27.36±3.26* |
阳性药组 | 17.45±2.38*Δ |
给药组1 | 16.45±2.08*Δ |
给药组2 | 12.45±2.18*Δ |
给药组3 | 14.48±2.21*Δ |
和正常组比较,*P<0.05;和模型组比较,ΔP<0.05
与正常组比较,模型组及各治疗组BUN水平均显著升高,表示造模成功;与模型组比较,治疗后各治疗组BUN水平明显下降,说明均具有治疗效果。
Claims (5)
1.一种治疗肾结石的中药组合物,其特征在于,它包含下列重量份的物质:生地5-15份、杭芍3-15份、当归3-12份、川芎5-15份、山药5-20份、枣皮3-15份、丹皮9-15份、泽泻3-10份、云芩3-15份、川牛膝3-15份、薏苡仁3-30份、杜仲10-20份、川断3-12份、丹参3-15份、香附3-10份、玄胡3-15份、鸡内金3-10份、海金沙3-20份、金钱草3-30份、木通3-10份、滑石10-20份、车前草10-20份、王不留行5-15份、炒山楂1-15份、白茅根20-50份。
2.根据权利要求1所述的治疗肾结石的中药组合物,其特征在于,它包含下列重量份的物质:生地10份、杭芍8份、当归6份、川芎10份、山药10份、枣皮10份、丹皮12份、泽泻8份、云芩10份、川牛膝10份、薏苡仁20份、杜仲15份、川断10份、丹参10份、香附8份、玄胡10份、鸡内金8份、海金沙10份、金钱草20份、木通8份、滑石15份、车前草15份、王不留行10份、炒山楂10份、白茅根30份。
3.根据权利要求2所述的治疗肾结石的中药组合物,其特征在于,它还包含下列重量份的物质:0.1份的具有下列结构式的物质:
4.根据权利要求3所述的治疗肾结石的中药组合物,其特征在于,所述中药组合物可以是洗剂、软膏剂或粉剂。
5.具有下列结构式的物质在制备治疗肾结石的药物中的用途:
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