CN105749226A - 一种治疗风湿类风湿及早期骨癌的中药组合物 - Google Patents

一种治疗风湿类风湿及早期骨癌的中药组合物 Download PDF

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CN105749226A
CN105749226A CN201610194438.7A CN201610194438A CN105749226A CN 105749226 A CN105749226 A CN 105749226A CN 201610194438 A CN201610194438 A CN 201610194438A CN 105749226 A CN105749226 A CN 105749226A
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parts
radix
rhizoma
chinese medicine
medicine composition
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郑秀红
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    • A61K36/18—Magnoliophyta (angiosperms)
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Abstract

本发明涉及一种治疗风湿类风湿及早期骨癌的中药组合物，它包含：制草乌、制川乌、羌活、独活、生白术、秦艽、四叶参、丁香、桂枝、黄芪、石斛、姜半夏、丹参、姜黄、当归、赤芍药、红花、鸡血藤、透骨草、海桐皮、生艾叶、女贞子、墨旱莲、桑葚子、侧柏、川芎、熟地、干姜、肉桂、白芥子、马钱子、杜仲、紫苏子、石菖蒲、木香、红景天、独一味、苍术、细辛、金凤花、牛膝、伸筋草、小茴香、地黄、五倍子、木瓜、天冬、茯苓和黄连。本发明所述的中药组合物协同作用效果好，能够有效治疗风湿类风湿疾病，同时对于腰椎间盘突出引起的腰腿疼痛、肢体麻木、间歇性跛行和骨骼疼痛也有很好的疗效，起到标本兼治的作用。

Description

一种治疗风湿类风湿及早期骨癌的中药组合物
技术领域
本发明涉及医药领域，具体来说涉及一种治疗风湿类风湿及早期骨癌的中药组合物。
背景技术
风湿病是一组侵犯关节、骨骼、肌肉、血管及有关软组织或结缔组织为主的疾病，其中多数为自身免疫性疾病。发病多较隐蔽而缓慢，病程较长，且大多具有遗传倾向。诊断及治疗均有一定难度；血液中多可检查出不同的自身抗体，可能与不同HLA亚型有关；对非甾类抗炎药(NSAID)，糖皮质激素和免疫抑制剂有较好的短期或长期的缓解性反应。
广义上认为凡是引起骨关节，肌肉疼痛的疾病皆可归属为风湿病。延续下来，至今在风湿病分类上，广义的已有100多种疾病，包括了感染性、免疫性、代谢性、内分泌性、遗传性、退行性、肿瘤性、地方性、中毒性等多种原因引起的疾病。狭义上应该仅限于内科与免疫相关范畴的几十种疾病。其中有些病还是跨学科的，如痛风，骨性关节病，感染性关节炎等。
发明内容
本发明的目的是提供一种治疗风湿类风湿及早期骨癌的中药组合物。
为了实现本发明的目的，本发明提供一种治疗风湿类风湿及早期骨癌的中药组合物，它包含下列重量份的物质：制草乌10-30份、制川乌10-30份、羌活10-30份、独活10-30份、生白术10-30份、秦艽10-30份、四叶参10-30份、丁香10-30份、桂枝10-30份、黄芪10-30份、石斛10-30份、姜半夏10-30份、丹参10-30份、姜黄10-30份、当归10-30份、赤芍药10-30份、红花10-30份、鸡血藤10-30份、透骨草10-30份、海桐皮10-30份、生艾叶10-30份、女贞子10-30份、墨旱莲10-30份、桑葚子10-30份、侧柏10-30份、川芎10-30份、熟地10-30份、干姜10-30份、肉桂10-30份、白芥子10-30份、马钱子10-30份、杜仲10-30份、紫苏子10-30份、石菖蒲10-30份、木香10-30份、红景天10-30份、独一味10-30份、苍术10-30份、细辛10-30份、金凤花10-30份、牛膝10-30份、伸筋草10-30份、小茴香10-30份、地黄10-30份、五倍子10-30份、木瓜10-30份、天冬10-30份、茯苓10-30份和黄连10-30份。
优选地，本发明所述的治疗风湿类风湿及早期骨癌的中药组合物包含下列重量份的物质：制草乌20份、制川乌20份、羌活20份、独活20份、生白术20份、秦艽20份、四叶参20份、丁香20份、桂枝20份、黄芪20份、石斛20份、姜半夏20份、丹参20份、姜黄20份、当归20份、赤芍药20份、红花20份、鸡血藤20份、透骨草20份、海桐皮20份、生艾叶20份、女贞子20份、墨旱莲20份、桑葚子20份、侧柏20份、川芎20份、熟地20份、干姜20份、肉桂20份、白芥子20份、马钱子20份、杜仲20份、紫苏子20份、石菖蒲20份、木香20份、红景天20份、独一味20份、苍术20份、细辛20份、金凤花20份、牛膝20份、伸筋草20份、小茴香20份、地黄20份、五倍子20份、木瓜20份、天冬20份、茯苓20份和黄连20份。
更优选地，本发明所述的治疗风湿类风湿及早期骨癌的中药组合物还包含0.05份的具有下列结构式的物质：
优选地，所述中药组合物可以是片剂、分散片、胶囊剂、丸剂或汤剂。
本发明还提供具有下列结构式的物质在制备治疗风湿类风湿及早期骨癌的药物中的用途：
本发明所述的中药组合物协同作用效果好，能够有效治疗风湿类风湿疾病，同时对于腰椎间盘突出引起的腰腿疼痛、肢体麻木、间歇性跛行和骨骼疼痛也有很好的疗效，起到标本兼治的作用。
具体实施方式
下面通过实施例进一步说明本发明。应该理解的是，本发明的实施例是用于说明本发明而不是对本发明的限制。根据本发明的实质对本发明进行的简单改进都属于本发明要求保护的范围。除非另有说明，否则本发明中的百分数是重量百分数。
实施例1
称取制草乌20克、制川乌20克、羌活20克、独活20克、生白术20克、秦艽20克、四叶参20克、丁香20克、桂枝20克、黄芪20克、石斛20克、姜半夏20克、丹参20克、姜黄20克、当归20克、赤芍药20克、红花20克、鸡血藤20克、透骨草20克、海桐皮20克、生艾叶20克、女贞子20克、墨旱莲20克、桑葚子20克、侧柏20克、川芎20克、熟地20克、干姜20克、肉桂20克、白芥子20克、马钱子20克、杜仲20克、紫苏子20克、石菖蒲20克、木香20克、红景天20克、独一味20克、苍术20克、细辛20克、金凤花20克、牛膝20克、伸筋草20克、小茴香20克、地黄20克、五倍子20克、木瓜20克、天冬20克、茯苓20克和黄连20克，粉碎，过100目筛，混合均匀得到粉末。
实施例2
化合物具有下列结构式：
实验例
对小鼠耳廓肿胀的影响
取体重18-22g健康昆明种小鼠50只，雌雄各半，随机分为5组：对照组、阳性药组、给药组1、给药组2、给药组3。每组10只。对照组给予生理盐水灌胃1mL/1000g体重；阳性药组给予地塞米松0.5g加1000mL生理盐水配制成混悬液，给予灌胃1mL/1000g体重；给药组1，实施例1的粉末10g加1000mL生理盐水配制成混悬液，给予灌胃1mL/1000g体重；给药组2，0.02g的化合物加1000mL生理盐水配制成混悬液，给予灌胃1mL/1000g体重；给药组3，实施例1的粉末5g和0.01g的化合物加1000mL生理盐水配制成混悬液，给予灌胃1mL/1000g体重。1次/日，连续给药7天。于末次给药30min后，将每只小鼠左耳廓均匀地涂二甲苯0.05ml/只，致炎15min后，将小鼠脱颈椎处死，用直径6.5mm的打孔器将双耳同部位切下，分别在电子天平上称重，以左、右耳片重量之差为肿胀度，计算各组肿胀率，采用t检验比较各给药组与对照组差异情况。结果见下表。(n＝10)
组别 肿胀率(％)
对照组 136.81±20.6
阳性药组 71.26±13.2*
给药组1 82.62±15.6*
给药组2 75.18±14.5*
给药组3 80.05±15.2*
注：与对照组比较*P＜0.05
结果表明，与对照组比较，本发明的药物均能抑制由二甲苯引起的小鼠耳廓肿胀(p＜0.05)，说明有较强的抗炎作用。

Claims (5)

1.一种治疗风湿类风湿及早期骨癌的中药组合物，其特征在于，它包含下列重量份的物质：制草乌10-30份、制川乌10-30份、羌活10-30份、独活10-30份、生白术10-30份、秦艽10-30份、四叶参10-30份、丁香10-30份、桂枝10-30份、黄芪10-30份、石斛10-30份、姜半夏10-30份、丹参10-30份、姜黄10-30份、当归10-30份、赤芍药10-30份、红花10-30份、鸡血藤10-30份、透骨草10-30份、海桐皮10-30份、生艾叶10-30份、女贞子10-30份、墨旱莲10-30份、桑葚子10-30份、侧柏10-30份、川芎10-30份、熟地10-30份、干姜10-30份、肉桂10-30份、白芥子10-30份、马钱子10-30份、杜仲10-30份、紫苏子10-30份、石菖蒲10-30份、木香10-30份、红景天10-30份、独一味10-30份、苍术10-30份、细辛10-30份、金凤花10-30份、牛膝10-30份、伸筋草10-30份、小茴香10-30份、地黄10-30份、五倍子10-30份、木瓜10-30份、天冬10-30份、茯苓10-30份和黄连10-30份。
2.根据权利要求1所述的治疗风湿类风湿及早期骨癌的中药组合物，其特征在于，它包含下列重量份的物质：制草乌20份、制川乌20份、羌活20份、独活20份、生白术20份、秦艽20份、四叶参20份、丁香20份、桂枝20份、黄芪20份、石斛20份、姜半夏20份、丹参20份、姜黄20份、当归20份、赤芍药20份、红花20份、鸡血藤20份、透骨草20份、海桐皮20份、生艾叶20份、女贞子20份、墨旱莲20份、桑葚子20份、侧柏20份、川芎20份、熟地20份、干姜20份、肉桂20份、白芥子20份、马钱子20份、杜仲20份、紫苏子20份、石菖蒲20份、木香20份、红景天20份、独一味20份、苍术20份、细辛20份、金凤花20份、牛膝20份、伸筋草20份、小茴香20份、地黄20份、五倍子20份、木瓜20份、天冬20份、茯苓20份和黄连20份。
3.根据权利要求1或2所述的治疗风湿类风湿及早期骨癌的中药组合物，其特征在于，它还包含0.05份的具有下列结构式的物质：
4.根据权利要求1或2所述的治疗风湿类风湿及早期骨癌的中药组合物，其特征在于，所述中药组合物可以是片剂、分散片、胶囊剂、丸剂或汤剂。
5.具有下列结构式的物质在制备治疗风湿类风湿及早期骨癌的药物中的用途：
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