CN105560441B - A kind of warm kidney is good for marrow, supplementing qi and nourishing yin, Chinese medicine composition of green blood hemostasis and preparation method thereof - Google Patents
A kind of warm kidney is good for marrow, supplementing qi and nourishing yin, Chinese medicine composition of green blood hemostasis and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of warm kidney is good for marrow, supplementing qi and nourishing yin, Chinese medicine composition of green blood hemostasis and preparation method thereof, the Chinese medicine composition is that Six-element Chinese medicine is prepared from altogether by melanterite, American Ginseng, hippocampus, Chinese cassia tree, date, walnut kernel；The medical instrument has warm kidney to be good for marrow, supplementing qi and nourishing yin, effect of green blood hemostasis；It is mainly used in treating alpastic anemia, leukopenia, thrombopenia, the bone marrow injury that myelodysplastic syndrome and radiation and chemotherapy cause, Neuroleptic Leukocytopenia belong to the insufficiency of the kidney yang, syndrome of deficiency of both qi and blood person.Its clinical pharrnacokinetics test effect is notable, and bioavilability is high, and without any side effects.
Description
Technical field
The present invention relates to a kind of warm kidney is good for marrow, supplementing qi and nourishing yin, Chinese medicine composition of green blood hemostasis and preparation method thereof, which is special
Point be have functions that warm kidney be good for marrow, supplementing qi and nourishing yin, green blood hemostasis, be mainly used in alpastic anemia, leukopenia,
The bone marrow injury that thrombopenia, myelodysplastic syndrome and radiation and chemotherapy cause, Neuroleptic Leukocytopenia belong to kidney yang not
Foot, syndrome of deficiency of both qi and blood person.Belong to pharmaceutical technology field.
Technical background
Class hemopoietic hypofunction of marrow and disorderly class disease are common and multiple a kind of diseases in clinic, clinical treatment ratio
More difficult, have a strong impact on the healthy of people.Chinese patent publication on June 8th, 2011 discloses entitled " a kind of
The application for a patent for invention of compound green vitriol capsule " Publication No. CN102085253A；Each bulk drug of the composition invention Chinese patent drug
Weight proportion be：Melanterite 8-10 part, American Ginseng 5-6 part, -4 parts of hippocampus 3, Chinese cassia tree 3-4 part, stoning date 6-8 part, walnut kernel
8-10 part.But we have found that the effect of this Chinese patent drug is not ideal enough in actual application.In the time in recent years,
We have carried out substantial amounts of test and have groped, looked on the basis of each bulk drug proportioning disclosed in this patent to each raw material survival dose
Arrived optimal prescription proportioning, clinical pharrnacokinetics experiment effect is significantly improved, we made pill, capsule, tablet and
Granula.
Content of the invention
Present invention aims to the defect existing for state of the art, imitates in conjunction with substantial amounts of pharmacodynamic experiment
Fruit study, provide a kind of curative effect significantly more " a kind of warm kidney be good for marrow, supplementing qi and nourishing yin, green blood stop blooding Chinese medicine composition and its
Preparation method ".
For reaching above-mentioned purpose, the technical solution used in the present invention is：
Pill of the present invention, capsule, tablet, the weight proportion of granule traditional Chinese medicinal composition raw materials are：
1st, the preparation method of Chinese medical pill composition of the present invention is：
Above Six-element, hippocampus, date are dried in 75 DEG C～80 DEG C；Walnut kernel is smashed to pieces, and walnut oil is collected in squeezing, and Chinese cassia tree adds water
Volatile oil is extracted, volatile oil merges standby, Chinese cassia tree extract concentration with walnut oil, and 70 DEG C of dryings, are got dry extract and remaining is Western
The five tastes mixed powders such as ginseng are broken into fine powder, sieve, and mix；Above-mentioned walnut oil and Cortex Cinnamomi volatile oil is sprayed into, is mixed, add refined honey per 100g
50～60g makes small honey pill, and microwave drying 15 minutes, heated-air drying 2 hours under conditions of 40 DEG C of microwave 250w hot blast, bag are lived
Property charcoal clothing, obtains final product pill.
2nd, the preparation method of capsule Chinese medicine composition of the present invention is：
Above Six-element, hippocampus, date are dried in 75 DEG C～80 DEG C；Walnut kernel is smashed to pieces, and walnut oil is collected in squeezing, and Chinese cassia tree adds water
Volatile oil is extracted, volatile oil merges standby, Chinese cassia tree extract concentration with walnut oil, and 70 DEG C of dryings, are got dry extract and remaining is Western
The five tastes mixed powders such as ginseng are broken into fine powder, sieve, and mix；Above-mentioned walnut oil and Cortex Cinnamomi volatile oil is sprayed into, proper auxiliary materials are added, mix
Even, granulation, microwave drying 15 minutes, heated-air drying 2 hours under conditions of 40 DEG C of microwave 250w hot blast, encapsulated, obtain final product glue
Wafer.
3rd, the preparation method of Tablets Chinese medicine composition is：
Above Six-element, hippocampus, date are dried in 75 DEG C～80 DEG C；Walnut kernel is smashed to pieces, and walnut oil is collected in squeezing, and Chinese cassia tree adds water
Volatile oil is extracted, volatile oil merges standby, Chinese cassia tree extract concentration with walnut oil, and 70 DEG C of dryings, are got dry extract and remaining is Western
The five tastes mixed powders such as ginseng are broken into fine powder, sieve, and mix；Above-mentioned walnut oil and Cortex Cinnamomi volatile oil is sprayed into, proper auxiliary materials are added, mix
Even, granulation, microwave drying 15 minutes, heated-air drying 2 hours under conditions of 40 DEG C of microwave 250w hot blast, compressing tablet, obtain final product tablet.
4th, the preparation method of granule Chinese medicine composition of the present invention is：
Above Six-element, hippocampus, date are dried in 75 DEG C～80 DEG C；Walnut kernel is smashed to pieces, and walnut oil is collected in squeezing, and Chinese cassia tree adds water
Volatile oil is extracted, volatile oil merges standby, Chinese cassia tree extract concentration with walnut oil, and 70 DEG C of dryings, are got dry extract and remaining is Western
The five tastes mixed powders such as ginseng are broken into fine powder, sieve, and mix；Above-mentioned walnut oil and Cortex Cinnamomi volatile oil is sprayed into, proper auxiliary materials are added, mix
Even, granulation, microwave drying 15 minutes, heated-air drying 2 hours under conditions of 40 DEG C of microwave 250w hot blast, pack, obtain final product particle
Agent.
For the deficiencies in the prior art, inventor is through concentrating on studies for many years, Chinese patent publication on June 8th, 2011
Disclose a kind of application for a patent for invention of entitled " compound green vitriol capsule " Publication No. CN102085253A；Composition invention
The weight proportion of each bulk drug of the Chinese patent drug is：Melanterite 8-10 part, American Ginseng 5-6 part, -4 parts of hippocampus 3, Chinese cassia tree 3-4 part,
Stoning date 6-8 part, walnut kernel 8-10 part.We in the time in recent years, in each bulk drug proportioning disclosed in this patent
On the basis of, substantial amounts of test has been carried out to each raw material survival dose and has been groped, have found optimal prescription proportioning：, clinical pharrnacokinetics reality
Effect is significant raising is tested, we have made pill, capsule, tablet and granule.
Beneficial effect of the present invention：The present invention has warm kidney and is good for marrow, supplementing qi and nourishing yin, the function of green blood hemostasis.The medicine is exclusively used in
Treat all kinds of hemopoietic hypofunction of marrow and disorderly class disease, such as alpastic anemia, myelodysplastic syndrome
(MDS), the abnormal blood difficult and complicated illness of the hematopoiesis function such as thrombopenia, also particularly as various malignant tumour Radiotherapy chemotherapies
When marrow protectant and " rise white " agent.According to market survey, the current domestic quasi-drugs as " efficient marrow protectant " are very
Few.As tumor chemoradiotherapy adjuvant drug, before chemicotherapy, take that invention formulation leucocyte can not reduce or minority case is thin in vain
Born of the same parents' slight decrease, while also there is marrow DNA and promote hemopoietic function of bone marrow, General Promotion haemocyte, and patient's infection generation
Rate is significantly reduced.The present invention is made up of melanterite, American Ginseng, hippocampus, Chinese cassia tree, date, walnut kernel.Melanterite：Acid, trembles with fear, tonify the blood and arrest bleeding,
Removing toxic substances eliminating dampness, monarch drug in a prescription in the side of being；American Ginseng：Sweet, slight bitter, cool, the thoughts of returning home, lung, kidney channel, supplementing qi and nourishing yin, clearing heat and promoting fluid；Hippocampus：It is sweet,
Temperature, returns liver and kidney channel, and warming and invigorating kidney Yang, kidney-nourishing essence, American Ginseng, hippocampus are ministerial drug in side altogether；Chinese cassia tree：Pungent, sweet, big heat, return kidney, spleen,
The heart, Liver Channel, mends fire supporing yang, let the fire back to its origin, invigorate blood circulation, adjutant in the side of being；Date：Sweet, temperature, returns spleen, stomach, nourishing qi and blood,
Bowl spares invigorating the spleen；Walnut kernel：Sweet, temperature, to return kidney, lung, large intestine channel, tonify the kidney and support yang, date, walnut kernel are altogether for making medicine in side.Full side is tight
The button interpretation of the cause, onset and process of an illness, rationally, both by eliminating dampness of detoxifying, replenish qi to invigorate the spleen excites source of generating QI and blood to compatibility, and energy replenishing essence Wen Yang is with kidney tonifying
Negative and positive, play warm kidney altogether and are good for marrow, supplementing qi and nourishing yin, the work(of green blood hemostasis.
Pharmacodynamic test of active extract is proved：Bulk drug weight proportion " melanterite 25g, American Ginseng 30g, hippocampus 3 0g, meat of the present invention
Osmanthus 45g, stoning date 60g, walnut kernel 30g " is with primary bright bulk drug weight proportion 1：8 parts of melanterite, 5 parts of American Ginseng, hippocampus 3
Part, 3 parts of Chinese cassia tree, 6 parts of stoning date, 8 parts of walnut kernel and primary bright bulk drug weight proportion 2：10 parts of melanterite, 6 parts of American Ginseng, sea
4 parts of horse, 4 parts of Chinese cassia tree, 8 parts of stoning date, 10 parts of walnut kernel are compared, and results of pharmacodynamic test is significantly increased.
Pharmacodynamic test of active extract
First, the preparation of Experimental agents：
1st, raw material：
Pill group of the present invention：By melanterite 25g, American Ginseng 30g, hippocampus 3 0g, Chinese cassia tree 45g, stoning date 60g, walnut kernel
Prepared by 30g.(by melanterite 25g of the present invention, American Ginseng 30g, hippocampus 3 0g, Chinese cassia tree 45g, stoning date 60g, walnut kernel 30g proportioning)
A, primary bright 1 group：By melanterite 53.4g, American Ginseng 33.4g, hippocampus 20.0g, Chinese cassia tree 20.0g, stoning date
Prepared by 40.0g, walnut kernel 53.4g.(by primary bright weight proportion 1：8 parts of melanterite, 5 parts of American Ginseng, hippocampus 3 part, 3 parts of Chinese cassia tree, go
6 parts of core date, 8 parts of proportionings of walnut kernel)
B, primary bright 2 groups：By melanterite 52.4g, American Ginseng 31.5g, hippocampus 21.0g, Chinese cassia tree 21.0g, stoning date
Prepared by 41.9g, walnut kernel 52.4g.(by primary bright weight proportion 2：10 parts of melanterite, 6 parts of American Ginseng, 4 parts of hippocampus, 4 parts of Chinese cassia tree,
8 parts of stoning date, 10 parts of proportionings of walnut kernel)
2nd, pill group of the present invention, a group, the preparation method of b group are：
Above Six-element, hippocampus, date are dried in 75 DEG C～80 DEG C；Walnut kernel is smashed to pieces, and walnut oil is collected in squeezing, and Chinese cassia tree adds water
Volatile oil is extracted, volatile oil merges standby, Chinese cassia tree extract concentration with walnut oil, and 70 DEG C of dryings, are got dry extract and remaining is Western
The five tastes mixed powders such as ginseng are broken into fine powder, sieve, and mix；Above-mentioned walnut oil and Cortex Cinnamomi volatile oil is sprayed into, is mixed, add refined honey per 100g
50～60g makes small honey pill, and microwave drying 15 minutes, heated-air drying 2 hours under conditions of 40 DEG C of microwave 250w hot blast, bag are lived
Property charcoal clothing, obtains final product pill.
2nd,：Process of the test and result of the test
Experiment purpose：By to the blood-supplementing blood-nourishing of pill group of the present invention, a group and b group, to recover marrow function, lifting blood little
The pharmacological experiment study of plate, hemostasis, resist oxygen lack and fatigue-resisting function, pill group of the present invention is contrasted with a group, b group, is seen
Examine the power of its pharmacological action.
Test method：Pill group of the present invention, the impact of a group and b group to deficiency of blood mouse blood；To caused by cyclophosphamide rat
The impact that bone marrow nucleated cell is reduced；The impact reduced by caused by cyclophosphamide mouse platelets；Mouse is docked the bleeding time
Impact；Impact to mouse resisting oxygen lack；Effect to mouse anti-reflecting fatigue.
First, the impact to deficiency of blood mouse blood
Experiment material
1st, animal：Kunming mouse, male and female half and half, 18～22g of body weight.
2nd, medicine：Pill group of the present invention, a group and b group.Medicine is configured with distilled water before experiment, gastric infusion.
Experimental technique
Kunming mouse 50, male and female half and half, 18～22g of body weight, be randomly divided into 5 groups, per group 10.In addition to control group,
Remaining 4 groups of mouse is distinguished afterbody bloodletting 0.5m1, so that animal is lost blood, Lost blood anemia model is caused, gastric infusion after 24h.Right
According to group and the physiological saline of model group gavage same volume；Pill group of the present invention, a group and b group difference gastric infusion 2.0g crude drug/
kg.Successive administration 7d, one time a day, and after last dose 2h, afterbody takes the value that blood surveys hemoglobin and red blood cell.Experimental result：See
Table 1
Impact of the table 1 to deficiency of blood mouse blood
Model group compares * * P ＜ 0.01；With a, b group than △ P ＜ 0.05.
As a result show：Pill group of the present invention, a group and b group are remarkably improved the level of hemoglobin and red blood cell, with model
Group has compared pole significant difference (P ＜ 0.01)；Pill group of the present invention has significant difference (P ＜ compared with a group, b group
0.05).It can be seen that, pill group of the present invention is stronger than the blood-supplementing blood-nourishing effect of a group, b group.
2nd, the impact reduced by caused by cyclophosphamide rat marrow karyocyte
Experiment material
1st, animal：SD rat, male and female half and half, 200～250g of body weight.
2nd, medicine：Pill group of the present invention, a group and b group.Medicine is configured with distilled water before experiment, gastric infusion.
Experimental technique
SD rat 50,200～250g of body weight, be randomly divided into 5 groups, per group 10.In addition to control group, remaining each group mouse
Hypodermic injection endoxan 70mg/kg, totally 2 times.Control group and the physiological saline of model group gavage same volume；Pill of the present invention
Group, a group and b group difference gastric infusion 1.2g crude drug/kg.Successive administration 7d, one time a day, puts to death animal in administration 8d and takes one
Side femur, counts bonemarrow nucleated cells number.Experimental result：It is shown in Table 2
Impact of the table 2 to bonemarrow nucleated cells number
Model group compares * * P ＜ 0.01；With a, b group than △ P ＜ 0.05.
As a result show：Pill group of the present invention, a group and b group are bright to the minimizing of caused by cyclophosphamide rat marrow karyocyte
Aobvious increasing action, has pole significant difference (P ＜ 0.01) compared with model group；Pill group of the present invention is had compared with a group, b group
Significant difference (P ＜ 0.05).It can be seen that, pill group of the present invention promotes the work of impaired hemopoietic function of bone marrow recovery than a group, b group
With strong.
3rd, the impact reduced by caused by cyclophosphamide mouse platelets
Experiment material
1st, animal：Kunming mouse, male and female half and half, 18～22g of body weight.
2nd, medicine：Pill group of the present invention, a group and b group.Medicine is configured with distilled water before experiment, gastric infusion.
Experimental technique
Kunming mouse 50, male and female half and half, 18～22g of body weight, be randomly divided into 5 groups, per group 10.In addition to control group,
Remaining each group mouse subcutaneous injection endoxan 100mg/kg.Control group and the physiological saline of model group gavage same volume；This
Bright pill group, a group and b group difference gastric infusion 2.0g crude drug/kg.Successive administration 10d, one time a day, takes blood in 10d tail point,
Platelet Counting number.Experimental result：It is shown in Table 3
The impact that table 3 is reduced to caused by cyclophosphamide mouse platelets
Model group compares * * P ＜ 0.01；With a, b group than △ P ＜ 0.05.
As a result show：Pill group of the present invention, a group and b group are significantly increased to the minimizing of caused by cyclophosphamide mouse platelets
Effect, have pole significant difference (P ＜ 0.01) compared with model group；Pill group of the present invention is had significantly compared with a group, b group
Sex differernce (P ＜ 0.05).It can be seen that, pill group of the present invention is stronger than a group, the effect of b group increased platelets counts.
4th, the impact to the mouse docking bleeding time
Experiment material
1st, animal：Kunming mouse, male and female have concurrently, 18～22g of body weight.
2nd, medicine：Pill group of the present invention, a group and b group.Medicine is configured with distilled water before experiment, gastric infusion.
Experimental technique
Kunming mouse 40, male and female half and half, 18～22g of body weight, be randomly divided into 4 groups, per group 10.Control group gavage is same
The physiological saline of volume；Pill group of the present invention, a group and b group difference gastric infusion 2.0g crude drug/kg.Successive administration 7d, daily 1
Secondary, each 20ml/kg.After last dose 30min, respectively that each group rat-tail is cross-section at tail point 5mm, after blood voluntarily overflows
Start timing with stopwatch, and drop of blood 1 time is sucked every 30s filter paper.With rat-tail section blood from overflowing and start timing, to filter
Nothing the blood time as the bleeding time during paper suction section, each group mouse bleeding time is recorded.Experimental result：It is shown in Table 4
Impact of the table 4 to the mouse docking bleeding time
* * P ＜ 0.01 compared with control group；With a, b group than △ P ＜ 0.05.
As a result show：Pill group of the present invention, a group and b group can substantially shorten the mouse bleeding time, have pole compared with control group
Significant difference (P ＜ 0.01)；Pill group of the present invention has significant difference (P ＜ 0.05) compared with a group, b group.It can be seen that, this
Invention pill group is stronger than the anastalsis of a group, b group.
5th, the impact to mouse resisting oxygen lack
Experiment material
1st, animal：Kunming mouse, male and female half and half, 18～22g of body weight.
2nd, medicine：Pill group of the present invention, a group and b group.Medicine is configured with distilled water before experiment, gastric infusion.
Experimental technique
Kunming mouse 40, male and female half and half, 18～22g of body weight, be randomly divided into 4 groups, per group 10.Control group gavage is same
The physiological saline of volume；Pill group of the present invention, a group and b group difference gastric infusion 2.0g crude drug/kg.Successive administration 7d, daily 1
Secondary, after last dose 1h, mouse is put in 250m1 wide-mouth bottle, around bottleneck, vaseline is applied, observe and to record anoxia in mice dead
When 20 DEG C of the room temperature that dies, with heartbeat stopping as dead mouse standard.Experimental result：It is shown in Table 5
Impact of the table 5 to mouse resisting oxygen lack
* * P ＜ 0.01 compared with control group；With a, b group than △ P ＜ 0.05.
As a result show：When pill group of the present invention, a group and b group can significantly extend survival of the mouse in atmospheric closed environment
Between, there is pole significant difference (P ＜ 0.01) compared with control group；Pill group of the present invention has conspicuousness poor compared with a group, b group
Different (P ＜ 0.05).It can be seen that, pill group of the present invention is stronger than the resisting oxygen lack of a group, b group.
6th, the effect to mouse anti-reflecting fatigue
Experiment material
1st, animal：Kunming mouse, male and female half and half, 18～22g of body weight.
2nd, medicine：Pill group of the present invention, a group and b group.Medicine is configured with distilled water before experiment, gastric infusion.
Experimental technique
Kunming mouse 40, male and female half and half, 18～22g of body weight, be randomly divided into 4 groups, per group 10.Control group gavage is same
The physiological saline of volume；Pill group of the present invention, a group and b group difference gastric infusion 2.0g crude drug/kg.Successive administration 7d, daily 1
Secondary, after last dose 1h, mouse is put people 55cm × 35cm × 15cm to mouse tail application of load (galvanized wire) by the 1O% by body weight
Swimming pool in 25 DEG C of water temperature, 27 DEG C of room temperature, observe mouse tail application of load swimming time, mouse nose submerged 10s is not
Emerged as index of drowning again.Experimental result：It is shown in Table 6
Effect of the table 6 to mouse anti-reflecting fatigue
* * P ＜ 0.01 compared with control group；With a, b group than △ P ＜ 0.05.
As a result show：Pill group of the present invention, a group and b group can be obviously prolonged the walking weight load of mouse, with control group phase
Than there is pole significant difference (P ＜ 0.01)；Pill group of the present invention has significant difference (P ＜ 0.05) compared with a group, b group.Can
See, pill group of the present invention is stronger than the antifatigue effect of a group, b group.
Experimental result：Pill group of the present invention, a group and b group are remarkably improved the level of hemoglobin and red blood cell；To ring phosphorus
Caused by acid amides, the minimizing of rat marrow karyocyte has significantly increasing action；Caused by cyclophosphamide mouse platelets are reduced and is carried
High effect；Substantially shorten the mouse bleeding time；Notable prolongation time-to-live of the mouse in atmospheric closed environment；Substantially can prolong
The walking weight load of long mouse.
Conclusion：Pill group of the present invention than a group, the blood-supplementing blood-nourishing of b group, recover marrow function, lifting blood platelet, hemostasis, resistance to
Anoxic and the pharmacological action such as antifatigue strong.Therefore, clinically pill group of the present invention than a group, b group for warm kidney be good for marrow, beneficial gas
Yin-nourishing, the effect of green blood hemostasis are strong.
Acute toxicity testing result shows：By pill group Cmax of the present invention, maximum volume gastric infusion, in 24h
Successive administration 3 times, per minor tick 4h, accumulation medicine total amount reaches 20g crude drug/kg, equivalent to clinical intend consumption 202 times.Administration
Afterwards in 7d, mouse activity, feed, excretion are all normal, well-grown, hair color light, its average weight all prolonging with test period
Grow and increase.At 8d, every mouse of post mortem visually observes the heart, liver, spleen, lung, kidney, brain, thymus gland, adrenal gland, stomach, intestines etc.
Color and paramophia are not all found.Show pill group of the present invention nothing acute toxic reaction.
Long term toxicity test result shows：Pill group of the present invention be divided into basic, normal, high dosage be respectively 3,6,12g crude drug/
Kg/d, 30.3,60.6,121.2 equivalent to clinical dosage times, gastric infusion is after 12 weeks, pill group of the present invention to animal
As situation, hematological indices, blood parameters all Wu significantly impact, the inspection of Systematic anatomy, organ coefficient and histopathology
Look into also no abnormal pathological change.It is discontinued 2 weeks and also has no substantially change.Pill group of the present invention in long term toxicity test, not
It was found that overt toxicity reaction and delayed toxicity reaction.It can be seen that, pill group non-toxic reaction of the present invention, long-term prescription are safe and reliable.
The specific embodiment of the invention：
Embodiment 1：The preparation of pill of the present invention
The weight proportion of bulk drug is：
Preparation method is：
Above Six-element, hippocampus, date are dried in 75 DEG C～80 DEG C；Walnut kernel is smashed to pieces, and walnut oil is collected in squeezing, and Chinese cassia tree adds water
Volatile oil is extracted, volatile oil merges standby, Chinese cassia tree extract concentration with walnut oil, and 70 DEG C of dryings, are got dry extract and remaining is Western
The five tastes mixed powders such as ginseng are broken into fine powder, sieve, and mix；Above-mentioned walnut oil and Cortex Cinnamomi volatile oil is sprayed into, is mixed, add refined honey per 100g
50～60g makes small honey pill, and microwave drying 15 minutes, heated-air drying 2 hours under conditions of 40 DEG C of microwave 250w hot blast, bag are lived
Property charcoal clothing, obtains final product pill.
Embodiment 2：The preparation of capsule of the present invention
The weight proportion of bulk drug is：
Preparation method is：
Above Six-element, hippocampus, date are dried in 75 DEG C～80 DEG C；Walnut kernel is smashed to pieces, and walnut oil is collected in squeezing, and Chinese cassia tree adds water
Volatile oil is extracted, volatile oil merges standby, Chinese cassia tree extract concentration with walnut oil, and 70 DEG C of dryings, are got dry extract and remaining is Western
The five tastes mixed powders such as ginseng are broken into fine powder, sieve, and mix；Above-mentioned walnut oil and Cortex Cinnamomi volatile oil is sprayed into, proper auxiliary materials are added, mix
Even, granulation, microwave drying 15 minutes, heated-air drying 2 hours under conditions of 40 DEG C of microwave 250w hot blast, encapsulated, obtain final product glue
Wafer.
Embodiment 3：The preparation of Tablets
The weight proportion of bulk drug is：
Preparation method is：
Above Six-element, hippocampus, date are dried in 75 DEG C～80 DEG C；Walnut kernel is smashed to pieces, and walnut oil is collected in squeezing, and Chinese cassia tree adds water
Volatile oil is extracted, volatile oil merges standby, Chinese cassia tree extract concentration with walnut oil, and 70 DEG C of dryings, are got dry extract and remaining is Western
The five tastes mixed powders such as ginseng are broken into fine powder, sieve, and mix；Above-mentioned walnut oil and Cortex Cinnamomi volatile oil is sprayed into, proper auxiliary materials are added, mix
Even, granulation, microwave drying 15 minutes, heated-air drying 2 hours under conditions of 40 DEG C of microwave 250w hot blast, compressing tablet, obtain final product tablet.
Embodiment 4：The preparation of granule of the present invention
The weight proportion of bulk drug is：
Preparation method is：
Above Six-element, hippocampus, date are dried in 75 DEG C～80 DEG C；Walnut kernel is smashed to pieces, and walnut oil is collected in squeezing, and Chinese cassia tree adds water
Volatile oil is extracted, volatile oil merges standby, Chinese cassia tree extract concentration with walnut oil, and 70 DEG C of dryings, are got dry extract and remaining is Western
The five tastes mixed powders such as ginseng are broken into fine powder, sieve, and mix；Above-mentioned walnut oil and Cortex Cinnamomi volatile oil is sprayed into, proper auxiliary materials are added, mix
Even, granulation, microwave drying 15 minutes, heated-air drying 2 hours under conditions of 40 DEG C of microwave 250w hot blast, pack, obtain final product particle
Agent.
Claims (6)
1. a kind of warm kidney is good for marrow, supplementing qi and nourishing yin, the Chinese medicine composition of green blood hemostasis, it is characterised in that the traditional Chinese medicine composite
The weight proportion of medicine is：
2. Chinese medicine composition according to claim 1, it is characterised in that the formulation of the Chinese medicine composition is：Pill, capsule
Agent, tablet or granule.
3. the preparation method of Chinese medicine composition according to claim 1 or claim 2, it is characterised in that the preparation method of the Chinese medicine composition
For：
Above Six-element, hippocampus, date are dried in 75 DEG C～80 DEG C；Walnut kernel is smashed to pieces, and walnut oil, Chinese cassia tree extracting in water are collected in squeezing
Volatile oil, volatile oil merges standby with walnut oil, and Chinese cassia tree extract is concentrated, 70 DEG C of dryings, got dry extract with remaining American Ginseng etc.
Five tastes mixed powder is broken into fine powder, sieves, and mixes；Spray into above-mentioned walnut oil and Cortex Cinnamomi volatile oil, mix, add per 100g refined honey 50～
60g makes small honey pill, microwave drying 15 minutes, heated-air drying 2 hours under conditions of 40 DEG C of microwave 250w hot blast, bag activated carbon
Clothing, obtains final product pill.
4. the preparation method of Chinese medicine composition according to claim 1 or claim 2, it is characterised in that the preparation method of the Chinese medicine composition
For：
Above Six-element, hippocampus, date are dried in 75 DEG C～80 DEG C；Walnut kernel is smashed to pieces, and walnut oil, Chinese cassia tree extracting in water are collected in squeezing
Volatile oil, volatile oil merges standby with walnut oil, and Chinese cassia tree extract is concentrated, 70 DEG C of dryings, got dry extract with remaining American Ginseng etc.
Five tastes mixed powder is broken into fine powder, sieves, and mixes；Above-mentioned walnut oil and Cortex Cinnamomi volatile oil is sprayed into, proper auxiliary materials are added, mix, system
Grain, microwave drying 15 minutes, heated-air drying 2 hours under conditions of 40 DEG C of microwave 250w hot blast, encapsulated, obtain final product capsule.
5. the preparation method of Chinese medicine composition according to claim 1 or claim 2, it is characterised in that the preparation method of the Chinese medicine composition
For：
Above Six-element, hippocampus, date are dried in 75 DEG C～80 DEG C；Walnut kernel is smashed to pieces, and walnut oil, Chinese cassia tree extracting in water are collected in squeezing
Volatile oil, volatile oil merges standby with walnut oil, and Chinese cassia tree extract is concentrated, 70 DEG C of dryings, got dry extract with remaining American Ginseng etc.
Five tastes mixed powder is broken into fine powder, sieves, and mixes；Above-mentioned walnut oil and Cortex Cinnamomi volatile oil is sprayed into, proper auxiliary materials are added, mix, system
Grain, microwave drying 15 minutes, heated-air drying 2 hours under conditions of 40 DEG C of microwave 250w hot blast, compressing tablet, obtain final product tablet.
6. the preparation method of Chinese medicine composition according to claim 1 or claim 2, it is characterised in that the preparation method of the Chinese medicine composition
For：
Above Six-element, hippocampus, date are dried in 75 DEG C～80 DEG C；Walnut kernel is smashed to pieces, and walnut oil, Chinese cassia tree extracting in water are collected in squeezing
Volatile oil, volatile oil merges standby with walnut oil, and Chinese cassia tree extract is concentrated, 70 DEG C of dryings, got dry extract with remaining American Ginseng etc.
Five tastes mixed powder is broken into fine powder, sieves, and mixes；Above-mentioned walnut oil and Cortex Cinnamomi volatile oil is sprayed into, proper auxiliary materials are added, mix, system
Grain, microwave drying 15 minutes, heated-air drying 2 hours under conditions of 40 DEG C of microwave 250w hot blast, pack, obtain final product granule.
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|---|---|---|---|
| CN201610157975.4A CN105560441B (en) | 2016-03-18 | 2016-03-18 | A kind of warm kidney is good for marrow, supplementing qi and nourishing yin, Chinese medicine composition of green blood hemostasis and preparation method thereof |
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| CN201610157975.4A CN105560441B (en) | 2016-03-18 | 2016-03-18 | A kind of warm kidney is good for marrow, supplementing qi and nourishing yin, Chinese medicine composition of green blood hemostasis and preparation method thereof |
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