CN105535791A - Traditional Chinese medicine preparation for treating gastroesophageal reflux and preparation method of traditional Chinese medicine preparation - Google Patents
Traditional Chinese medicine preparation for treating gastroesophageal reflux and preparation method of traditional Chinese medicine preparation Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating gastroesophageal reflux and a preparation method of the traditional Chinese medicine preparation, and belongs to the field of traditional Chinese medicine. The effective ingredients of the traditional Chinese medicine preparation comprise the following raw materials: philippine paphiopedilum, angelica dahurica, pericarpium arecae, Japanese flowering quince, alhagi-honey, rice bean flower, symplocos paniculata, garlic, folium callicarpae pedunculalae, toona sinensis, amomum cardamomum, herb of cornuted pugionium, ramulus mori, saururus chinensis, spotted ardiaia herb and fructus aurantii. The traditional Chinese medicine preparation disclosed by the invention is appropriate in medicinal material compatibility, conforms to the theories of traditional Chinese medicines and modern medicines, has the effects of harmonizing stomach and lowering adverse Qi, promoting blood circulation to remove blood stasis, and soothing liver and regulating Qi, has a unique curative effect on the treatment of the gastroesophageal reflux, is obvious in curative effect and convenient to take, achieves the effect that the recurrence possibility is low after recovery, is safe without toxic or side effect, can achieve the purpose of treating both symptoms and root causes, is lower in cost, quickly takes effects and is worthy of wide clinical popularization and application.
Description
Art
The present invention relates to the field of Chinese medicines, particularly relate to a kind of Chinese medicine preparation and the preparation method that are used for the treatment of gastroesophageal reflux.
Background technology
The disease of the clinical gastroesophageal reflux disease that stomach esophageal lumen causes because of excessive contact gastric juice and Esophageal Mucosa damage is called gastroesophageal reflux.Gastroesophageal reflux and complication thereof be multifactorial, comprising the defect of the anti-reflux mechanism of esophagus own, as inferior esophageal sphincter dysfunction and EB dyskinesia etc.; Also the dysfunction of the outer many mechanical factors of esophagus is had.
Heartburn and acid regurgitation: heartburn refers to after breastbone and burn feeling under xiphoid-process, how occurred at one hour after the meal, flatly to crouch, bend over or abdominal pressure increases time easily occur, the gastric content of reflux entrance cavity is often called acid regurgitation in acidity, acid regurgitation often accompanies heartburn, is the modal symptom of primary disease.Swallowing pain and dysphagia: have when serious esophagitis or esophageal ulcer and can occur swallowing pain, is stimulated caused by the sensory nerve ending under epithelium of esophagus by acid reflux thing.Reflux thing also can stimulate mechanoreceptor to cause esohagismus pain, can be violent twinge time serious, support or oppose, waist, shoulder, cervical region radiation, exactly like angina pectoris.Due to esohagismus or dysfunction, some patients again can dysphagia, and when there is esophagostenosis, dysphagia continues to increase the weight of.Reflux thing stimulates pharyngeal mucosa to cause pharyngolaryngitis, occurs hoarseness, pharyngeal discomfort or foreign body sensation.Suck respiratory tract can cough, asthma, this asthma without seasonality, there is paroxysmal cough and asthma in night of being everlasting.There is aspiration pneumonitis in few patients, even occurs interstitial pulmonary fibrosis repeatedly.
Along with the development of society, the quickening of rhythm of life, the change etc. of dietary structure, sickness rate is in rising trend, greatly have impact on the quality of life of patient.Although current western medical treatment gastroesophageal reflux obtains good curative effect, the course for the treatment of compared with long, to cure the symptoms, not the disease and side effect is large, to patient with very large misery, therefore select a kind of Chinese medicine preparation to treat the misery that gastroesophageal reflux thoroughly can solve patient.
Summary of the invention
The invention provides a kind of Chinese medicine preparation and the preparation method that are used for the treatment of gastroesophageal reflux; Selected by Chinese medicine preparation of the present invention, medical material compatibility is suitable, meet Chinese medicine and pharmacy and modern medicine theory, and there is effect of regulating the stomach and sending down the abnormal ascending QI, blood circulation promoting and blood stasis dispelling, depressed liver-energy dispersing and QI regulating, to treatment gastroesophageal reflux, there is unique curative effect, and it is evident in efficacy, taking convenience, non-relapse after healing, safe without toxic side effect, the object for the treatment of both the principal and secondary aspects of a disease can be reached, cost is lower, quick result, wide popularization and application on clinic.
For achieving the above object, technical scheme of the present invention is implemented as follows:
Be used for the treatment of a Chinese medicine preparation for gastroesophageal reflux, raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Philippine Paphiopedilum (Concolor Paphiopedilum) 12 ~ 36 parts of Radixs Angelicae Dahuricae 11 ~ 35 parts of Pericarpium Arecae 10 ~ 34 parts of Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd. 10 ~ 34 parts
7 ~ 31 parts, Mel Alhagi 9 ~ 33 parts of Flos Phaseolis 9 ~ 33 portions of Symplocoris Paniculataes 8 ~ 32 portions of Bulbus Alliis
Folium Callicarpae Formosanae 7 ~ 31 parts of Folium toonae sinensis 6 ~ 30 portions of Fructus Amomi Rotunduss 5 ~ 29 parts of Herba Pugionii Cornutis 5 ~ 29 parts
Ramulus Mori 5 ~ 29 parts of Rhizoma Saururi (Herba Saururi)s 3 ~ 27 parts of Herba Ardisiae Maculosaes 1 ~ 25 part of Fructus Aurantii 1 ~ 25 part.
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Philippine Paphiopedilum (Concolor Paphiopedilum) 16 ~ 32 parts of Radixs Angelicae Dahuricae 15 ~ 31 parts of Pericarpium Arecae 14 ~ 30 parts of Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd. 14 ~ 30 parts
11 ~ 27 parts, Mel Alhagi 13 ~ 29 parts of Flos Phaseolis 13 ~ 29 portions of Symplocoris Paniculataes 12 ~ 28 portions of Bulbus Alliis
Folium Callicarpae Formosanae 11 ~ 27 parts of Folium toonae sinensis 10 ~ 26 portions of Fructus Amomi Rotunduss 9 ~ 25 parts of Herba Pugionii Cornutis 9 ~ 25 parts
Ramulus Mori 9 ~ 25 parts of Rhizoma Saururi (Herba Saururi)s 7 ~ 23 parts of Herba Ardisiae Maculosaes 5 ~ 21 parts of Fructus Aurantiis 5 ~ 21 parts.
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Philippine Paphiopedilum (Concolor Paphiopedilum) 20 ~ 28 parts of Radixs Angelicae Dahuricae 19 ~ 27 parts of Pericarpium Arecae 18 ~ 26 parts of Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd. 18 ~ 26 parts
15 ~ 23 parts, Mel Alhagi 17 ~ 25 parts of Flos Phaseolis 17 ~ 25 portions of Symplocoris Paniculataes 16 ~ 24 portions of Bulbus Alliis
Folium Callicarpae Formosanae 15 ~ 23 parts of Folium toonae sinensis 14 ~ 22 portions of Fructus Amomi Rotunduss 13 ~ 21 parts of Herba Pugionii Cornutis 13 ~ 21 parts
Ramulus Mori 13 ~ 21 parts of Rhizoma Saururi (Herba Saururi)s 11 ~ 19 parts of Herba Ardisiae Maculosaes 9 ~ 17 parts of Fructus Aurantiis 9 ~ 17 parts.
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Philippine Paphiopedilum (Concolor Paphiopedilum) 24 parts of Radixs Angelicae Dahuricae 23 parts of Pericarpium Arecae 22 parts of Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd. 22 parts
19 parts, Mel Alhagi 21 parts of Flos Phaseolis 21 portions of Symplocoris Paniculataes 20 portions of Bulbus Alliis
Folium Callicarpae Formosanae 19 parts of Folium toonae sinensis 18 portions of Fructus Amomi Rotunduss 17 parts of Herba Pugionii Cornutis 17 parts
Ramulus Mori 17 parts of Rhizoma Saururi (Herba Saururi)s 15 parts of Herba Ardisiae Maculosaes 13 parts of Fructus Aurantiis 13 parts.
Be used for the treatment of a preparation method for the Chinese medicine preparation of gastroesophageal reflux, comprise following processing step:
(1) Philippine Paphiopedilum (Concolor Paphiopedilum) and Rhizoma Saururi (Herba Saururi) are cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(2) Radix Angelicae Dahuricae, Folium Callicarpae Formosanae and Herba Pugionii Cornuti are put into container, carry out pulverization process, grind into powder, 180 object fine powders must be, for subsequent use;
(3) Pericarpium Arecae, Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd., Mel Alhagi, Flos Phaseoli, Symplocoris Paniculatae, Bulbus Allii, Folium toonae sinensis, Fructus Amomi Rotundus, Ramulus Mori and Fructus Aurantii are cleaned, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.13, for subsequent use;
(4) cleaned by Herba Ardisiae Maculosae, immerse the alcohol solution dipping 1 ~ 2 hour of 60% of 3 times amount, heating extraction 3 hours, reclaim ethanol, filter, obtain filtrate, at simmer down to 65 DEG C, relative density is the thick paste of 1.12 ~ 1.16, for subsequent use;
(5) juice, fine powder and thick paste obtained by above-mentioned steps (1) ~ (4) are made capsule, obtain the described Chinese medicine preparation being used for the treatment of gastroesophageal reflux.
The property of medicine of the present invention's Chinese medicine used is as follows:
Philippine Paphiopedilum (Concolor Paphiopedilum): bitter in the mouth, acid, property is put down.Relieving cough and asthma, wind-expelling pain-stopping.For pulmonary tuberculosis, bronchitis, asthma, rheumatic ostalgia, rheumatoid arthritis, chronic gastralgia, gastroenteritis.
The Radix Angelicae Dahuricae: acrid in the mouth, warm in nature, attach to the lung and stomach meridians.Expelling wind and cold, understand things pain-stopping, detumescence and apocenosis, dampness leukorrhagia stopping.Profit blood vessels, expelling wind and cold, eliminating dampness and dredging channels, is widely used in the treatment of the diseases such as soft tissue contusion, hyperosteogeny, muscular strain, rheumatic myositis, fracture, costal chondritis, scapulohumeral periarthritis, intercostal neuralgia.The Radix Angelicae Dahuricae all has inhibitory action to escherichia coli, dysentery bacterium, Bacillus proteus, Bacillus typhi, Salmonella paratyphi, bacillus pyocyaneus, vibrio cholera, Bacillus tuberculosis etc.
Pericarpium Arecae: acrid in the mouth, slightly warm in nature is nontoxic; Return spleen, lung, stomach warp.Therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, row water.Control gastral cavity abdomen painful abdominal mass swollen, beriberi, edema." Japan hanako materia medica " carries: " all gas lower, only cholera, logical intestine and small intestine, spleen benefiting and stimulating the appetite, in tune.”
Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd.: sour-puckery flavor, property is put down; Return spleen, stomach, large intestine channel.Stomach function regulating removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral.Main vomiting and diarrhoea, soreness of waist and knee joint, beriberi swells and ache, sural spasm.Supplement to the Herbal carries: " remove feel sick acid pharynx, only wine expectorant yellow fluid.”
Mel Alhagi: sweet in the mouth, acid, property is put down; GUIXIN, lung, spleen, small intestinal, kidney channel.Convergence astringing intestine to stop diarrhea, pain relieving.Main dysentery, diarrhoea, abdominal distention, hectic fever due to YIN-deficiency excessive thirst, headache, toothache.Supplement to the Herbal carries: " main bone heat, phlegmatic cough, the sudden and violent hematochezia of dysentery, appetizing, quenches the thirst, relieving restlessness.”
Flos Phaseoli: acrid in the mouth, slightly cool in nature; GUIXIN, spleen, stomach, large intestine channel.Removing toxic substances and promoting subsidence of swelling, promoting the circulation of QI to induce diuresis, improving eyesight.Cure mainly furuncle erysipelas, insobriety, abdominal distention and little diet, edema, liver-heat conjunctival congestion is dim-sighted." property of medicine opinion " carries: " disappear alcoholism, improving eyesight.Loose fullness caused by stagnant QI can not be eaten, boil a decoction being taken at a draught it.Descend aqueous vapor again, and it is swollen to control infantile erysipelas heat.”
Symplocoris Paniculatae: bitter in the mouth, puckery, cold nature.Heat-clearing and toxic substances removing, regulating QI eliminating stagnation, dispelling wind for relieving itching, antiinflammatory softening the hard mass, regulating QI.Main mastitis, lymphadenitis, acute appendicitis, furuncle, hernia, urticaria, skin pruritus, gastric cancer, furuncle.
Bulbus Allii: acrid in the mouth, sweet, warm in nature; Enter spleen, stomach, lung meridian.Removing toxic substances parasite killing, reducing swelling and alleviating pain, antidiarrheal dysentery relieving, controls lung, anthelmintic, warming the spleen warming the stomach.Control swollen ulcer drug, white bald tinea skin ulcer, dysentery, has loose bowels, pulmonary tuberculosis pertussis, ascarid pinworm, eating accumulation, coldness and pain in the epigastrium, edema distension." occupying diet spectrum with breath " carries: " survivor is hot, the sweet temperature of ripe person, and eliminating cold-damp, wards off YIN pathogen, and in lower hot air heating, grain-meat digesting, broken stagnant blood, attacks cold long-pending.Control sudden attack of spouting diarrhea stomachache, the constipation of clearance lattice, wards off dirty removing toxic substances, the painful abdominal mass that disappears parasite killing.Outer moxibustion carbuncle, row water is nosebleed only.”
Folium Callicarpae Formosanae: bitter in the mouth, puckery, property is put down.Hemostasis, dissipating blood stasis, antiinflammatory.For epistaxis, spitting of blood, gastrointestinal hemorrhage, metrorrhagia, upper respiratory tract infection, tonsillitis, pneumonia, bronchitis; Traumatic hemorrhage is controlled in external, burn." illustrated handbook planted by middle traditional Chinese medicines " carries: " hemorrhage to esophageal vein, intestine gastric ulcer is hemorrhage, epistaxis, wound hemorrhage, pneumorrhagia and have tooth pulled out and hemorrhagely all have good effect.”
Folium toonae sinensis: acrid in the mouth, hardship, property is put down; GUIXIN, spleen, large intestine channel.Antiinflammatory, removing toxic substances, parasite killing.Control enteritis, dysentery, furuncle, cellulitis, dermatitis rhus, scabies, bald in vain." Luchuan book on Chinese herbal medicine " carries: " stomach invigorating, hemostasis, antiinflammatory, parasite killing.Control metritis, enteritis, dysentery, urethritis.”
Fructus Amomi Rotundus: acrid in the mouth, warm in nature; Return lung, spleen, stomach warp.Removing dampness circulation of qi promoting, warming middle-JIAO to arrest vomiting.Control the stagnation of QI, dyspepsia, uncomfortable in chest, abdominal distention, eructation, dysphagic, tell inverse, regurgitation, malaria." medicine origin " carries: " loose stagnant gas in the heart, the cold stomachache of sense, warm taste, acute conjunctivitis breaks out, the red person of white of the eye for " curing mainly secret wanting " cloud, this medicine of lung gold.”
Herba Pugionii Cornuti: acrid in the mouth, warm in nature; GUIXIN, lung, stomach warp.Circulation of qi promoting, pain relieving, helps digestion, removing toxic substances.Main fullness and distention in the chest and hypochondrium, dyspepsia, alimentary toxicosis." Inner Mongol Chinese herbal medicine " carries: " circulation of qi promoting, pain relieving help digestion, removing toxic substances.Control dyspepsia, fullness and distention in the chest and hypochondrium, alimentary toxicosis.”
Ramulus Mori: bitter in the mouth, property is put down; Enter Liver Channel.Wind-damp dispelling, sharp joint, row aqueous vapor.Control anemofrigid-damp arthralgia, spasm of the limbs, beriberi edema, human body pruritus due to wind pathogen." Bencao Tujing " carries: " treat all over body pruritus due to wind pathogen dry, beriberi pathogenic wind, spasm of the limbs, upper gas, feels dizzy, and lung qi is coughed, and helps digestion; Diuresis, holds concurrently and treats xerostomia.”
Rhizoma Saururi (Herba Saururi): sweet in the mouth, pungent, cold in nature; Return lung, spleen, stomach, large intestine channel.Clearing away heat and promoting diuresis, removing toxic substances and promoting subsidence of swelling.Cure mainly pyretic stranguria, stranguria with blood, edema, beriberi, jaundice, dysentery, leukorrhagia, carbuncle sore tumefacting virus, eczema, venom.Modern medicine study confirms, the obvious antiinflammatory action of hyperin tool contained by Rhizoma Saururi (Herba Saururi), 1.50% decoct has inhibitory action and stronger antitussive action to staphylococcus aureus, Bacillus typhi and suppresses the effect of eye aldose reductase, may be useful to the cataract that prevents diabetes.
Herba Ardisiae Maculosae: acrid in the mouth, hardship, slightly warm in nature; Return liver, kidney, lung meridian.Promoting blood circulation and stopping pain, clearing throat.Main traumatic injury, fracture, rheumatic arthralgia, diphtheria, laryngopharynx swelling and pain, gastric ulcer.
Fructus Aurantii: bitter in the mouth, pungent, sour, warm in nature; Return spleen, stomach warp.Regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.For the breast side of body stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion, stops in phlegm retention; Gastroptosis, proctoptosis, sub-official's prolapsus." Japan hanako materia medica " carries: " spleen benefiting and stimulating the appetite, adjust the five internal organs, the therapeutic method to keep the adverse QI flowing downwards, preventing or arresting vomiting is inverse, expectorant.Control regurgitation, cholera dysentery, helps digestion, and broken crux mass beside the umbilicus, five types of dysphagia, except wind improving eyesight and lung qi edema, sharp intestine and small intestine, skin is itched.Swollen can the processing of hemorrhoid is pressed." modern medicine study confirmation, Fructus Aurantii can produce diuresis by suppressing other effects such as reabsorption.
The present invention compared with prior art, has following beneficial effect:
Selected by Chinese medicine preparation of the present invention, medical material compatibility is suitable, meet Chinese medicine and pharmacy and modern medicine theory, and there is effect of regulating the stomach and sending down the abnormal ascending QI, blood circulation promoting and blood stasis dispelling, depressed liver-energy dispersing and QI regulating, to treatment gastroesophageal reflux, there is unique curative effect, and it is evident in efficacy, taking convenience, non-relapse after healing, safe without toxic side effect, the object for the treatment of both the principal and secondary aspects of a disease can be reached, cost is lower, quick result, wide popularization and application on clinic.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
Philippine Paphiopedilum (Concolor Paphiopedilum) 32g Radix Angelicae Dahuricae 31g Pericarpium Arecae 30g Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd. 30g
Mel Alhagi 29g Flos Phaseoli 29g Symplocoris Paniculatae 28g Bulbus Allii 27g
Folium Callicarpae Formosanae 27g Folium toonae sinensis 26g Fructus Amomi Rotundus 25g Herba Pugionii Cornuti 25g
Ramulus Mori 25g Rhizoma Saururi (Herba Saururi) 23g Herba Ardisiae Maculosae 21g Fructus Aurantii 21g.
Be used for the treatment of a preparation method for the Chinese medicine preparation of gastroesophageal reflux, comprise following processing step:
(1) Philippine Paphiopedilum (Concolor Paphiopedilum) and Rhizoma Saururi (Herba Saururi) are cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(2) Radix Angelicae Dahuricae, Folium Callicarpae Formosanae and Herba Pugionii Cornuti are put into container, carry out pulverization process, grind into powder, 180 object fine powders must be, for subsequent use;
(3) Pericarpium Arecae, Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd., Mel Alhagi, Flos Phaseoli, Symplocoris Paniculatae, Bulbus Allii, Folium toonae sinensis, Fructus Amomi Rotundus, Ramulus Mori and Fructus Aurantii are cleaned, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.13, for subsequent use;
(4) cleaned by Herba Ardisiae Maculosae, immerse the alcohol solution dipping 1 ~ 2 hour of 60% of 3 times amount, heating extraction 3 hours, reclaim ethanol, filter, obtain filtrate, at simmer down to 65 DEG C, relative density is the thick paste of 1.12 ~ 1.16, for subsequent use;
(5) juice, fine powder and thick paste obtained by above-mentioned steps (1) ~ (4) are made capsule, obtain the described Chinese medicine preparation being used for the treatment of gastroesophageal reflux.
Usage and dosage: oral, after meal warm water delivery service, every day 2 times, each 1 time sooner or later, each 1 (every 0.5g), within 5 days, be 1 course for the treatment of, 1 ~ 3 course for the treatment of can fully recover, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Embodiment 2
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
Philippine Paphiopedilum (Concolor Paphiopedilum) 28g Radix Angelicae Dahuricae 27g Pericarpium Arecae 26g Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd. 26g
Mel Alhagi 25g Flos Phaseoli 25g Symplocoris Paniculatae 24g Bulbus Allii 23g
Folium Callicarpae Formosanae 23g Folium toonae sinensis 22g Fructus Amomi Rotundus 21g Herba Pugionii Cornuti 21g
Ramulus Mori 21g Rhizoma Saururi (Herba Saururi) 19g Herba Ardisiae Maculosae 17g Fructus Aurantii 17g.
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 3
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
Philippine Paphiopedilum (Concolor Paphiopedilum) 24g Radix Angelicae Dahuricae 23g Pericarpium Arecae 22g Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd. 22g
Mel Alhagi 21g Flos Phaseoli 21g Symplocoris Paniculatae 20g Bulbus Allii 19g
Folium Callicarpae Formosanae 19g Folium toonae sinensis 18g Fructus Amomi Rotundus 17g Herba Pugionii Cornuti 17g
Ramulus Mori 17g Rhizoma Saururi (Herba Saururi) 15g Herba Ardisiae Maculosae 13g Fructus Aurantii 13g.
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 4
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
Philippine Paphiopedilum (Concolor Paphiopedilum) 20g Radix Angelicae Dahuricae 19g Pericarpium Arecae 18g Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd. 18g
Mel Alhagi 17g Flos Phaseoli 17g Symplocoris Paniculatae 16g Bulbus Allii 15g
Folium Callicarpae Formosanae 15g Folium toonae sinensis 14g Fructus Amomi Rotundus 13g Herba Pugionii Cornuti 13g
Ramulus Mori 13g Rhizoma Saururi (Herba Saururi) 11g Herba Ardisiae Maculosae 9g Fructus Aurantii 9g.
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 5
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
Philippine Paphiopedilum (Concolor Paphiopedilum) 16g Radix Angelicae Dahuricae 15g Pericarpium Arecae 14g Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd. 14g
Mel Alhagi 13g Flos Phaseoli 13g Symplocoris Paniculatae 12g Bulbus Allii 11g
Folium Callicarpae Formosanae 11g Folium toonae sinensis 10g Fructus Amomi Rotundus 9g Herba Pugionii Cornuti 9g
Ramulus Mori 9g Rhizoma Saururi (Herba Saururi) 7g Herba Ardisiae Maculosae 5g Fructus Aurantii 5g.
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Clinical data:
1, case selection:
As the Chinese medicine preparation being used for the treatment of gastroesophageal reflux, select the routine clinical observation of patients with gastroesophageal reflux 168 of making a definite diagnosis, patient is divided into treatment group and matched group two groups at random, treatment group 84 example, wherein male 42 example, women 42 example, 31 ~ 64 years old age, 47.5 years old mean age, average course of disease 2 years; Matched group 84 example, wherein male 42 example, women 42 example, 30 ~ 65 years old age, 47.5 years old mean age, average course of disease 2 years.
The course of disease, the degrees of symptoms for the treatment of group and matched group two groups of cases are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group takes Chinese medicine preparation of the present invention, oral, after meal warm water delivery service, every day 2 times, and each 1 time sooner or later, each 1 (every 0.5g) 5 days is 1 course for the treatment of, takes 1 ~ 3 course for the treatment of continuously, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Matched group takes almitrine and raubasine sheet, oral, one time 1,2 times on the one, sooner or later take after the meal; Maintenance dose one time 1,1 time on the one, the course for the treatment of is depending on the state of an illness.
Omeprazole capsule, oral, 20 ~ 60mg (a time 1 ~ 3), 1 time on the one, rises and swallows, be generally 4 ~ 8 weeks the course for the treatment of morning.
3, efficacy determination:
(1) cure: clinical symptoms and sign all disappear, and physical recovery is normal.
(2) effective: clinical symptoms and sign obviously alleviate, and health takes a turn for the better to some extent.
(3) effective: clinical symptoms and sign alleviate to some extent, and health is clearly better.
(4) invalid: by treating rear upper clinical symptoms and sign without alleviating or increasing the weight of.
4, result:
Above result display, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
Model case is illustrated:
1, Hao, female, 35 years old, Xiangtan, Hunan Province people.Stomach in Patients amine portion burns discomfort, also with acid regurgitation, feel sick etc. symptom, remove examination in hospital, diagnosis suffer from gastroesophageal reflux disease, take Chinese medicine preparation of the present invention treatment, after taking 1 course for the treatment of, symptom is clearly better, after continuing to take 1 course for the treatment of, transference cure, recovery from illness, follows up a case by regular visits to and does not recur so far.
2, hole, man, 41 years old, people from Suining, Sichuan.Patient's distending pain in the chest and hypochondrium, acid regurgitation belch goes to hospital to do esophagus and gastroscopy is shown as gastroesophageal reflux, some Western medicine of frequent use, but therapeutic effect is undesirable, through taking Chinese medicine preparation of the present invention treatment, after taking 1 course for the treatment of, symptom is clearly better, after taking 3 courses for the treatment of, and transference cure, recovery from illness, follows up a case by regular visits to after 1 year without recurrence.
3, Bai, female, 39 years old, people from Yangjiang, Guangdong.Often there is stomachache, acid regurgitation, vomiting phenomenon at ordinary times in patient, can not eat the irritant thing of stomach at ordinary times, hospital gastroscope inspection is gone to be shown as gastroesophageal reflux, take Chinese medicine preparation of the present invention treatment, after taking 1 course for the treatment of, symptom is alleviated to some extent, after continuing to take 2 courses for the treatment of, symptom all disappears, recovery from illness.
4, Cui, man, 54 years old, Zhejiang Huzhou people.Patient's fullness and distention in the chest and hypochondrium, distending pain, and with pantothenic acid, heartburn, go hospital gastroscope to check Diagnosis of Gastric esophageal reflux, give Chinese medicine preparation of the present invention treatment, after taking 1 course for the treatment of, symptom is alleviated to some extent, after taking 2 courses for the treatment of, transference cure, recovery from illness, follows up a case by regular visits to after half a year without recurrence.
5, health, female, 47 years old, Huainan, Anhui people.Patient occurs heartburn without obvious inducement, acid regurgitation, feels sick, gastral cavilty is noisy, and appetite is poor, goes hospital gastroscope inspection to be shown as gastroesophageal reflux, used Drug therapy, had no any improvement, through taking Chinese medicine preparation of the present invention treatment, after taking 1 course for the treatment of, symptom takes a turn for the better to some extent, and after continuing to take 2 courses for the treatment of, symptom all disappears, recovery from illness, follows up a case by regular visits to so far without recurrence.
6, hair, man, 50 years old, people from changzhou.Scorching hot vexed pain after patient's breastbone, mood is gloomy, and emotion changes is aggravation then, goes hospital gastroscope inspection, be diagnosed as gastroesophageal reflux, take Chinese medicine preparation of the present invention treatment, after taking 1 course for the treatment of, symptom is alleviated to some extent, after taking 3 courses for the treatment of, symptom all disappears, recovery from illness, follows up a case by regular visits to without recurrence after half a year.
Claims (5)
1. be used for the treatment of a Chinese medicine preparation for gastroesophageal reflux, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Philippine Paphiopedilum (Concolor Paphiopedilum) 12 ~ 36 parts of Radixs Angelicae Dahuricae 11 ~ 35 parts of Pericarpium Arecae 10 ~ 34 parts of Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd. 10 ~ 34 parts
7 ~ 31 parts, Mel Alhagi 9 ~ 33 parts of Flos Phaseolis 9 ~ 33 portions of Symplocoris Paniculataes 8 ~ 32 portions of Bulbus Alliis
Folium Callicarpae Formosanae 7 ~ 31 parts of Folium toonae sinensis 6 ~ 30 portions of Fructus Amomi Rotunduss 5 ~ 29 parts of Herba Pugionii Cornutis 5 ~ 29 parts
Ramulus Mori 5 ~ 29 parts of Rhizoma Saururi (Herba Saururi)s 3 ~ 27 parts of Herba Ardisiae Maculosaes 1 ~ 25 part of Fructus Aurantii 1 ~ 25 part.
2. a kind of Chinese medicine preparation being used for the treatment of gastroesophageal reflux according to claim 1, is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Philippine Paphiopedilum (Concolor Paphiopedilum) 16 ~ 32 parts of Radixs Angelicae Dahuricae 15 ~ 31 parts of Pericarpium Arecae 14 ~ 30 parts of Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd. 14 ~ 30 parts
11 ~ 27 parts, Mel Alhagi 13 ~ 29 parts of Flos Phaseolis 13 ~ 29 portions of Symplocoris Paniculataes 12 ~ 28 portions of Bulbus Alliis
Folium Callicarpae Formosanae 11 ~ 27 parts of Folium toonae sinensis 10 ~ 26 portions of Fructus Amomi Rotunduss 9 ~ 25 parts of Herba Pugionii Cornutis 9 ~ 25 parts
Ramulus Mori 9 ~ 25 parts of Rhizoma Saururi (Herba Saururi)s 7 ~ 23 parts of Herba Ardisiae Maculosaes 5 ~ 21 parts of Fructus Aurantiis 5 ~ 21 parts.
3. a kind of Chinese medicine preparation being used for the treatment of gastroesophageal reflux according to claim 1, is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Philippine Paphiopedilum (Concolor Paphiopedilum) 20 ~ 28 parts of Radixs Angelicae Dahuricae 19 ~ 27 parts of Pericarpium Arecae 18 ~ 26 parts of Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd. 18 ~ 26 parts
15 ~ 23 parts, Mel Alhagi 17 ~ 25 parts of Flos Phaseolis 17 ~ 25 portions of Symplocoris Paniculataes 16 ~ 24 portions of Bulbus Alliis
Folium Callicarpae Formosanae 15 ~ 23 parts of Folium toonae sinensis 14 ~ 22 portions of Fructus Amomi Rotunduss 13 ~ 21 parts of Herba Pugionii Cornutis 13 ~ 21 parts
Ramulus Mori 13 ~ 21 parts of Rhizoma Saururi (Herba Saururi)s 11 ~ 19 parts of Herba Ardisiae Maculosaes 9 ~ 17 parts of Fructus Aurantiis 9 ~ 17 parts.
4. a kind of Chinese medicine preparation being used for the treatment of gastroesophageal reflux according to claim 1, is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Philippine Paphiopedilum (Concolor Paphiopedilum) 24 parts of Radixs Angelicae Dahuricae 23 parts of Pericarpium Arecae 22 parts of Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd. 22 parts
19 parts, Mel Alhagi 21 parts of Flos Phaseolis 21 portions of Symplocoris Paniculataes 20 portions of Bulbus Alliis
Folium Callicarpae Formosanae 19 parts of Folium toonae sinensis 18 portions of Fructus Amomi Rotunduss 17 parts of Herba Pugionii Cornutis 17 parts
Ramulus Mori 17 parts of Rhizoma Saururi (Herba Saururi)s 15 parts of Herba Ardisiae Maculosaes 13 parts of Fructus Aurantiis 13 parts.
5. as described in any one of Claims 1 to 4, be used for the treatment of a preparation method for the Chinese medicine preparation of gastroesophageal reflux, it is characterized in that: comprise following processing step:
(1) Philippine Paphiopedilum (Concolor Paphiopedilum) and Rhizoma Saururi (Herba Saururi) are cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(2) Radix Angelicae Dahuricae, Folium Callicarpae Formosanae and Herba Pugionii Cornuti are put into container, carry out pulverization process, grind into powder, 180 object fine powders must be, for subsequent use;
(3) Pericarpium Arecae, Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd., Mel Alhagi, Flos Phaseoli, Symplocoris Paniculatae, Bulbus Allii, Folium toonae sinensis, Fructus Amomi Rotundus, Ramulus Mori and Fructus Aurantii are cleaned, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.13, for subsequent use;
(4) cleaned by Herba Ardisiae Maculosae, immerse the alcohol solution dipping 1 ~ 2 hour of 60% of 3 times amount, heating extraction 3 hours, reclaim ethanol, filter, obtain filtrate, at simmer down to 65 DEG C, relative density is the thick paste of 1.12 ~ 1.16, for subsequent use;
(5) juice, fine powder and thick paste obtained by above-mentioned steps (1) ~ (4) are made capsule, obtain the described Chinese medicine preparation being used for the treatment of gastroesophageal reflux.
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