Summary of the invention
The invention provides a kind of Chinese medicine preparation and preparation method for the treatment of esophagitis; Selected by invention Chinese medicine preparation, medical material compatibility is suitable, meet Chinese medicine and pharmacy and modern medicine theory, and there is effect of heat clearing and inflammation relieving, relieving cough and asthma, regulating QI to relieve pain, to the symptom such as nausea and vomiting, dyspepsia, stomach distension, hyperchlorhydria caused by treatment esophagitis, there is significant curative effect, short treating period, instant effect, have no side effect, and security performance is high, special effect is practical, is worth wide popularization and application clinically.
For achieving the above object, technical scheme of the present invention is implemented as follows:
Treat a Chinese medicine preparation for esophagitis, raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Treat a preparation method for the Chinese medicine preparation of esophagitis, comprise following processing step:
(1) Philippine Paphiopedilum (Concolor Paphiopedilum) and Corm Eleocharitis are cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(2) Radix Triostei Pinnatifidi, the Radix Pulsatillae, Fructus Quisqualis, Carnis Arca inflata, Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Caryophylli, Rhizoma Phragmitis and Dendrobium jenkinsii Wall ex Lindl. are cleaned, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.13, for subsequent use;
(3) Herba Carlinae biebersteinii, Fructus Aristolochiae Kwangsiensis, Semen Viciae fabae, Endothelium Corneum Gigeriae Galli and Radix potentillae anserinae are put into container, carry out pulverization process, grind into powder, cross 180 order fine powders, for subsequent use;
(4) cleaned by Radix Et Rhizoma Fagopyri Tatarici, immerse the alcohol solution dipping 1 ~ 2 hour of 80% of 5 times amount, heating extraction 3 hours, reclaim ethanol, filter, obtain filtrate, at simmer down to 65 DEG C, relative density is the thick paste of 1.12 ~ 1.16, for subsequent use;
(5) by juice, thick paste and the fine powder mixing obtained by above-mentioned steps (1) ~ (4), make tablet, obtain the Chinese medicine preparation for the treatment of esophagitis of the present invention.
The property of medicine of the present invention's Chinese medicine used is as follows:
Philippine Paphiopedilum (Concolor Paphiopedilum): bitter in the mouth, acid, property is put down.Relieving cough and asthma, wind-expelling pain-stopping.For pulmonary tuberculosis, bronchitis, asthma, rheumatic ostalgia, rheumatoid arthritis, chronic gastralgia, gastroenteritis.
Radix Triostei Pinnatifidi: bitter in the mouth, puckery, property is put down.Wind-damp dispelling, vital energy regualting and blood circulation-promoting, strengthening the spleen and stomach, anti-inflammatory analgesic, granulation promoting.Control impairment caused by overstrain, lumbago, skelalgia of rheumatism, traumatic injury, dyspepsia, menoxenia, leucorrhea.
Herba Carlinae biebersteinii: sweet in the mouth, acid, micro-salty, warm in nature; Return spleen, liver, kidney channel.Strengthening the spleen and stomach, strengthening by means of tonics, regulating menstruation and activating blood.Control asthenic body, deficiency of both QI and blood, incoordination between the spleen and stomach, dyspepsia, menoxenia, waist abdomen pain.
The Radix Pulsatillae: bitter in the mouth, cold in nature; Return stomach, large intestine channel.Heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, removing dampness and killing parasites.Cure mainly dysentery, epistaxis, metrorrhagia, internal hemorrhoid with bleeding, cold and heat pyrexial malaria, leukorrhagia, pudendal pruritus, eczema, scrofula, carbuncle skin ulcer, eyes swelling pain." Japan hanako materia medica " carries: " control all pathogenic wind and warm waist knee joint, improving eyesight, disappears superfluous.Son: function is the same.”
Fructus Quisqualis: sweet in the mouth, warm in nature; Return spleen, stomach warp.Killing insect and eliminating accumulation.For ascarid, enterobiasis, abdominal pain due to worm stagnation, infantile malnutrition." detailed outline " carries: " strengthening the spleen and stomach, except deficiency-heat.Control children's's all kinds of diseases and ailments skin ulcer tinea.”
Carnis Arca inflata: sweet in the mouth, warm in nature; Return spleen, stomach warp.Enrich blood, warming middle-JIAO, stomach invigorating.Cure mainly blood deficiency scabies numbness, stomachache, dyspepsia, dysentery pus and blood." medical center bun will " carries: " reinforcing the heart blood, dissipating blood stasis blood, relieving restlessness relieving alcoholic intoxication, the expectorant of broken knot.”
Fructus Aristolochiae Kwangsiensis: bitter in the mouth, cold in nature; Return stomach warp.Heat-clearing and toxic substances removing, regulating QI to relieve pain, relaxing muscles and tendons and activating QI and blood in the collateral.For acute gastroenteritis, taste-blindness rate, pharyngolaryngitis, pulmonary tuberculosis, main ulcer sore pain, stomachache, abdominalgia with intestinal abscess, rheumatic arthralgia, treating swelling and pain by traumatic injury." register planted by Guangxi medicine " carries: " refrigerantly to bring down a fever, removing toxic substances.Control dizziness, laryngalgia, gastropathy, stomachache, skin ulcer scabies, knife injury, snakebite.”
Pseudobulbus Bletillae (Rhizoma Bletillae): acrid in the mouth, hardship, sweet, puckery, cold nature; Return lung, liver, stomach warp.Tonifying the lung is stopped blooding, detumescence and promoting granulation, sore.Control lung and hinder hemoptysis, epistaxis, incised wound is hemorrhage, swollen ulcer drug, canker sores, and soup fire is burnt, rhagadia manus et pedis." Bencao Tujing " carry: " control incised wound not to be recovered, in carbuncle side multiplex it." modern medicine study confirmation, it is active that Pseudobulbus Bletillae (Rhizoma Bletillae) can strengthen platelet factor III, significantly shortens clotting time and thrombinogen formation time, and suppress plasmin enzymatic activity, have anastalsis to local hemorrhage, its water decoction has antibacterial action.
Semen Viciae fabae: sweet in the mouth, micro-pungent, property is put down; Return spleen, stomach, heart channel.Invigorating spleen for diuresis, removing toxic substances and promoting subsidence of swelling.Main diaphragm food, edema, sore." Hunan medicine will " carries; " spleen invigorating, hemostasis, diuresis.”
Corm Eleocharitis: sweet in the mouth, cold in nature, nontoxic.Promoting the production of body fluid for nourishing the lung, reduce phlegm sharp intestinal, diuresis promoting, and eliminating carbuncle detoxifies, and removing heat from blood removing dampness, help digestion de-swelling.Cure mainly calentura to quench one's thirst, jaundice, conjunctival congestion, laryngopharynx swelling and pain, urine red heat is deficient, affection due to external wind and heat, the diseases such as mass in the abdomen.Modern medicine study confirms, Corm Eleocharitis all has certain inhibitory action to staphylococcus aureus, escherichia coli and bacillus pyocyaneus, and the heat that can disappear removes expectorant, reduces blood pressure.
Endothelium Corneum Gigeriae Galli: sweet in the mouth, cold in nature; Return spleen, stomach, small intestinal, urinary bladder channel.Promoting digestion and invigorating the stomach, has aid digestion, arresting seminal emission.Modern medicine study confirms, Endothelium Corneum Gigeriae Galli can promote gastric secretion, improves gastric acidity and eupepsy, stomach motor function is obviously strengthened, rapid gastric emptying." the southern regions of the Yunnan Province book on Chinese herbal medicine " carries: " alleviating distention in middle-JIAO spleen invigorating, help digestion mill stomach.Control children's's breast food knot stagnant, the large muscle of tripe is blue or green, mass in the abdomen infantile malnutrition.”
Flos Caryophylli: sweet in the mouth, pungent, hot greatly; Enter stomach, kidney two warp.Warming the stomach the kidney warming.Control cold syndrome of the stomach pain with distension, singultus, vomit and diarrhoea, arthralgia pain, colic, halitosis, toothache." Japan hanako materia medica " carries: " control implication, regurgitation, treat kidney qi, sensation of gas rushing, pain over the perineum, tonifying YANG, warm waist knee joint, killing wine Chinese medicine ' Flos Caryophylli ' real is Myrtaceae Flos Caryophylli poison, and disappear mass beside the umbilicus, except consumptive disease with cold nature.”
Radix potentillae anserinae: sweet in the mouth, property is put down; Return spleen, stomach warp.Fill blood, strengthening the spleen and stomach, promoting the production of body fluid to quench thirst, dampness removing.For anemia after being ill, malnutrition, insufficiency of the spleen diarrhoea, rheumatic arthralgia." Chinese herbal medicine is commonly used in Tibet " carries: " vigorate qi and replenish the blood, controls insufficiency of the spleen diarrhoea, after being ill anemia, malnutrition for invigorating spleen and reinforcing stomach, promoting the production of body fluid to quench thirst.”
Radix Et Rhizoma Fagopyri Tatarici: sweet in the mouth, property is put down; Return spleen, stomach, large intestine channel.Spleen invigorating row is stagnant, regulating QI to relieve pain, removing toxic substances and promoting subsidence of swelling.Cure mainly epigastric distending pain, dyspepsia, dysentery, lumbago and skelalgia, traumatic injury, carbuncle malignant boil, lyssodexis." Inner Mongol Chinese herbal medicine " carries: " removing damp and stopping pain, removing toxic substances and promoting subsidence of swelling, stomach invigorating.Control traumatic injury, lumbago and skelalgia, sore and toxic, dyspepsia.”
Rhizoma Phragmitis: sweet in the mouth, cold in nature; Attach to the lung and stomach meridians.Clearing away heat and promoting production of body fluid, relieves restlessness and prevents vomiting, diuresis.For calentura excessive thirst, gastropyretic vomiting, cough due to lung-heat, lung abscess vomiting pus, the puckery pain of pyretic stranguria." Japan hanako materia medica " carries: " when controlling cold and heat, disease is unhappy, good pregnant people's heat in the heart, and dysentery people is thirsty.”
Dendrobium jenkinsii Wall ex Lindl.: sweet in the mouth, light, cool in nature; Attach to the lung and stomach meridians.Nourishing the lung to arrest cough, tonifying-Yin and nourishing-stomach.Cure mainly cough due to lung-heat, pulmonary tuberculosis, asthma, dysentery, stomatitis, stomachache, infant malnutrition.
The present invention compared with prior art, has following beneficial effect:
Selected by Chinese medicine preparation of the present invention, medical material compatibility is suitable, meet Chinese medicine and pharmacy and modern medicine theory, and there is effect of heat clearing and inflammation relieving, relieving cough and asthma, regulating QI to relieve pain, to the symptom such as nausea and vomiting, dyspepsia, stomach distension, hyperchlorhydria caused by treatment esophagitis, there is significant curative effect, short treating period, instant effect, have no side effect, and security performance is high, special effect is practical, is worth wide popularization and application clinically.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
The preparation method of Chinese medicine preparation of the present invention, comprises following processing step:
(1) Philippine Paphiopedilum (Concolor Paphiopedilum) and Corm Eleocharitis are cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(2) Radix Triostei Pinnatifidi, the Radix Pulsatillae, Fructus Quisqualis, Carnis Arca inflata, Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Caryophylli, Rhizoma Phragmitis and Dendrobium jenkinsii Wall ex Lindl. are cleaned, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.13, for subsequent use;
(3) Herba Carlinae biebersteinii, Fructus Aristolochiae Kwangsiensis, Semen Viciae fabae, Endothelium Corneum Gigeriae Galli and Radix potentillae anserinae are put into container, carry out pulverization process, grind into powder, cross 180 order fine powders, for subsequent use;
(4) cleaned by Radix Et Rhizoma Fagopyri Tatarici, immerse the alcohol solution dipping 1 ~ 2 hour of 80% of 5 times amount, heating extraction 3 hours, reclaim ethanol, filter, obtain filtrate, at simmer down to 65 DEG C, relative density is the thick paste of 1.12 ~ 1.16, for subsequent use;
(5) by juice, thick paste and the fine powder mixing obtained by above-mentioned steps (1) ~ (4), make tablet, obtain the Chinese medicine preparation for the treatment of esophagitis of the present invention.
Usage and dosage: oral, every day 2 times, each 1 time sooner or later, each 2 (every sheet 0.4g), warm water delivery service after meal; Within 6 days, be 1 course for the treatment of, 2 ~ 3 courses for the treatment of can fully recover, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Embodiment 2
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 3
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 4
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 5
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Clinical data:
1, case selection:
As the Chinese medicine preparation for the treatment of esophagitis, select the routine clinical observation of esophagitis patient 460 of making a definite diagnosis, patient is divided into treatment group and matched group two groups at random, treatment group 230 example, wherein male 115 example, women 115 example, 10 ~ 63 years old age, 36.5 years old mean age, average course of disease 1 year; Matched group 230 example, wherein male 115 example, women 115 example, 11 ~ 62 years old age, 36.5 years old mean age, average course of disease 1 year.
The course of disease, the degrees of symptoms for the treatment of group and matched group two groups of cases are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group takes Chinese medicine preparation of the present invention, oral, every day 2 times, each 1 time sooner or later, each 2 (every sheet 0.4g), warm water delivery service after meal; Within 6 days, be 1 course for the treatment of, 2 ~ 3 courses for the treatment of can fully recover, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Matched group takes ranitidine hydrochloride capsules, oral, 150mg (a time 1), 2 times on the one, or 300mg (a time 2), sleeps first 1 time.
3, efficacy determination:
(1) cure: cardinal symptom all disappears, and gastroscopy esophagus functional rehabilitation is as usual.
(2) effective: cardinal symptom obviously alleviates, gastroscopy esophagus function takes a turn for the better to some extent.
(3) effective: cardinal symptom alleviates to some extent, and gastroscopy esophagus function is clearly better.
(4) invalid: by treating rear cardinal symptom without alleviating or increasing the weight of.
4, result:
Select in the treatment group of Chinese medicine preparation of the present invention, cure 164 examples, effective 51 examples, effective 13 examples, invalid 2 examples, cure rate 71.3%, total effective rate 99.1%.
82 examples are cured, effective 44 examples, effective 11 examples, invalid 93 examples, cure rate 35.7%, total effective rate 59.6% in matched group.
Above result display, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
Model case is illustrated:
1, Liao, man, 11 years old, people from Xuhui District, Shanghai.Patient suffers from Reflux exophagitis, difficulty when swallowing solid and liquid food, and without symptoms such as generate heat, have sore throat, through taking Chinese medicine preparation of the present invention treatment, after taking 1 course for the treatment of, symptom is obviously alleviated, and after continuing to take 2 courses for the treatment of, symptom all disappears, and fully recovers.
2, Zou, female, 22 years old, Beibei, chongqing people from district.Patient suffers from Reflux exophagitis, plays cough, out of breath morning every day, and take Chinese medicine preparation of the present invention treatment, after taking 1 course for the treatment of, symptom takes a turn for the better to some extent, and after taking 2 courses for the treatment of of the present invention, transference cure, recovery from illness, follows up a case by regular visits to after 1 year without recurrence.
3, hole, man, 31 years old, people from Fuxin, Liaoning.Patient suffers from esophagitis, and red swelling of the pharynx dry cough is not stopped, and take Chinese medicine preparation of the present invention treatment, after taking 1 course for the treatment of, symptom alleviates to some extent, after continuing to take 1 course for the treatment of, and transference cure, recovery from illness.
4, Bai, female, 45 years old, people from Handan, Hebei.Patient suffers from Reflux exophagitis 3 years, and retrosternal pain discomfort increases the weight of, and has burn feeling, and mouth is poured out one's grievances, dry pharynx, and after feed metasternum, pain is obvious, yellowish complexion color, emaciated physique.Take Chinese medicine preparation of the present invention treatment, after taking 1 course for the treatment of, symptom is clearly better, and after taking 2 courses for the treatment of, symptom all disappears, and follows up a case by regular visits to without recurrence after half a year.
5, Qiu, man, 53 years old, Tongling, Anhui Province people.Patient suffers from the Reflux exophagitis several years, uses western medicines in treatment, heavy time light during the state of an illness, throat esophageal do pain, belch, time have sour water, catch cold postemphasis, take Chinese medicine preparation of the present invention treatment, after taking 1 course for the treatment of, symptom alleviates to some extent, after continuing to take 2 courses for the treatment of, transference cure, recovery from illness.
6, river, female, 60 years old, From Anshun of Guizhou people.Patient suffers from Reflux exophagitis 4 years, stomach acid regurgitation, heartburn, increases the weight of during horizontal position, occasionally have chest pain, Abdeminal pain is uncomfortable, feed postemphasis, once drug administration treatment half a year, can not complete incidence graph symptom, symptom recurrence after drug withdrawal, recommend to take Chinese medicine preparation of the present invention treatment through people, after taking 1 course for the treatment of, symptom obviously alleviates, after taking 3 courses for the treatment of, symptom all disappears, recovery from illness.