CN105535595A - Traditional Chinese medicine composition for calming nerves, tranquilizing, clearing dryness-heat and alleviating mental illness and preparation method thereof - Google Patents
Traditional Chinese medicine composition for calming nerves, tranquilizing, clearing dryness-heat and alleviating mental illness and preparation method thereof Download PDFInfo
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- CN105535595A CN105535595A CN201510998270.0A CN201510998270A CN105535595A CN 105535595 A CN105535595 A CN 105535595A CN 201510998270 A CN201510998270 A CN 201510998270A CN 105535595 A CN105535595 A CN 105535595A
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- hoopoe
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Abstract
The invention discloses a traditional Chinese medicine composition for calming nerves, tranquilizing, clearing dryness-heat and alleviating mental illness and a preparation method thereof. The composition is prepared from the following components: whole grass of Cardamine hirsuta L., whole grass of Dregea yunnanensis (Tsiang) Tsiang et P. T. Li, root of Serissa serissoides, whole grass of Rhodobryum giganteum (Schwaegr.) Par., whole grass of Plagiopus oederi (Brid.) Limpr., radix asparagi, spire of henon bamboo, seed of Diospyros lotus, whole grass of Goodyera schlechtendaliana Rchb. F., rhizome of Panicum repens L., pine root wrapped by fushen, Melitodes ochracea(Linnaeus), whole grass of Filifoliumsibiricum(L.)Kitam., hoopoe micropowder, cornu gorais micropowder, lotus micropowder, borneol micropowder, a common andrographis herb extract and a bengal waterdropwort herb extract. The traditional Chinese medicine composition for calming nerves, tranquilizing, clearing heat and alleviating mental illness is formed by reasonably selecting traditional Chinese medicines and elaborately preparing by using a traditional Chinese medicine dialectic method and combining with clinical experience, has the effects of nourishing the brain and calming nerves, softening liver for calming endogenous wind, tranquilizing and clearing dryness-heat, clearing heat-fire and relieving the pressure, can effectively alleviate various symptoms of mental illness, realizes conditioning from inside to outside, can adjust visceral malfunctions and disordered meridian functions, improves the mental stress capacity of a patient, and is remarkable in effect, mild in medicine effect, high in safety and free of side effect.
Description
Technical field
The present invention relates to technical field, specifically relate to one calm clearing away dryness of calming the nerves and alleviate psychotic Chinese medicine composition and preparation method thereof.
Background technology
Along with the development of society, the pressure of work and life constantly increases, and China psychotic increases year by year, current China is mentally ill patient 100,000,000 people, psychosis is many between twenty and fifty morbidity in period, some interval outbreaks, some continuing advances, and be tending towards chronicity gradually, relapse rate is high, disability rate is high, as not active treatment, can occur mental deterioration and personality changes, can not social life be adapted to, be difficult to the responsibility should undertaken family and society.
Psychosis refers to cerebral function activity incidence rate disorderly, causes the general name of the ergasias such as understanding, emotion, behavior and the will disease of obstacle in various degree.Many mental patients have vain hope, hallucination, illusion, affective disorder, cry and laugh by turns, without any apparent reason, murmur to oneself, behavior is strange, hypobulia, and most humans lacks insight, does not admit that oneself is ill, does not initiatively seek the help of doctor.
If existing drug main is conceived to the control of nervus centralis, the nerve that patient carries out in various degree is suppressed, make patient calm down very soon after taking medicine, be a kind of maintenance treatment method temporarily controlled nerve, this type of medicine needs long-term taking, easily cause patient to the dependence of medicine and drug resistance, the lighter's general malaise, severe one has a convulsion, and side effect is larger, and easily recur after drug withdrawal, cure rate is low.
The traditional Chinese medical science is thought, if the ergasia of people has exceeded normal limit or has been subject to unexpected and permanent stimulation, and lack psychological stress ability and disposal skill, physiology and visceral dysfunction will be caused, meridian function is disorderly and mental sickness occurs, psychotic pathogenesis with kidney, liver, the heart, spleen four is dirty gets involved as work, deficiency of the kidney yin, the kidney failing to nourish the liver and cause that deficiecny of liver-YIN, liver-yang are partially high, high liver fire, liver-wind stirring up internally, therefore being called " wind is insane " that psychotic symptoms is had, controlling suppressing the hyperactive liver to relieve the wind syndrome to be main.Stagnation of QI due to depression of the liver, edema with the liver involved gram spleen soil, stagnation of dampness due to deficiency of the spleen, wet consor expectorant, control should dispersing the stagnated live-QI to relieve the stagnation of QI, invigorating the spleen for dissipating phlegm, record in "Nei Jing", " all manic more all belong to fiery ".State in Jing-Yue Complete Works: " mad disease many because of in fire ", controlling should clearing away heat-fire.It can thus be appreciated that the conditioning for kidney, liver, the heart, spleen is the important means for the treatment of mental sickness, to this, the Chinese medicine of motherland has in a large number for the settling mode of above-mentioned symptom, but has no the medicine of the treatment mental sickness based on Chinese medicine at present.In addition mental confusion due to phlegm, coagulation of QI-blood, negative and positive are become estranged and heredity etc. also can cause the generation of this type of disease.
Summary of the invention
The technical problem that the present invention solves is to provide one calm clearing away dryness of calming the nerves and alleviates psychotic Chinese medicine composition and preparation method thereof.
Technical scheme of the present invention is:
One calm clearing away dryness of calming the nerves alleviates psychotic Chinese medicine composition, by weight, it is be prepared from by following composition: flexuose bittercress herb and seed 80 ~ 150 parts, Dregea yunnanensis (Tsiang) Tsiang 76 ~ 140 parts, Radix Serissae 75 ~ 135 parts, Rhodobryum giganteum(Hook.) Par. 70 ~ 130 parts, Plagiopus oederi (Brid.) Limpr.(Polytrichum annotinum L.) 64 ~ 128 parts, Radix Asparagi 22 ~ 36 parts, Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendle 20 ~ 35 parts, Fructus Dispyroris Loti 18 ~ 30 parts, Paphio-pedilum micranthum Tang et Wang 15 ~ 25 parts, Herba panici repentics 13 ~ 21 parts, Lignum Poria 12 ~ 18 parts, seabed cypress 9 ~ 15 parts, rabbit hair Artemisia 8 ~ 12 parts, hoopoe micropowder 6 ~ 12 parts, Cornu Naemorhedi micropowder 5 ~ 10 parts, Flos Nelumbinis micropowder 4 ~ 9 parts, Borneolum micropowder 3 ~ 6 parts, Herba Andrographis extract 0.2 ~ 0.4 part, oenanthe javanica extract 0.1 ~ 0.3 part.
Optimum ratio: flexuose bittercress herb and seed 115 parts, Dregea yunnanensis (Tsiang) Tsiang 108 parts, Radix Serissae 105 parts, Rhodobryum giganteum(Hook.) Par. 100 parts, Plagiopus oederi (Brid.) Limpr.(Polytrichum annotinum L.) 96 parts, Radix Asparagi 29 parts, Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendle 27.5 parts, Fructus Dispyroris Loti 24 parts, Paphio-pedilum micranthum Tang et Wang 20 parts, Herba panici repentics 17 parts, Lignum Poria 15 parts, seabed cypress 12 parts, rabbit hair Artemisia 10 parts, hoopoe micropowder 9 parts, Cornu Naemorhedi micropowder 7.5 parts, Flos Nelumbinis micropowder 6.5 parts, Borneolum micropowder 4.5 parts, Herba Andrographis extract 0.3 part, oenanthe javanica extract 0.2 part.
Further, the particle diameter of described hoopoe micropowder, Cornu Naemorhedi micropowder, Flos Nelumbinis micropowder, Borneolum micropowder is 1 ~ 50 μm; Preparation method is: hoopoe and Cornu Naemorhedi are placed in 50 ~ 70 DEG C of low temperature in frying pan and bake 25 minutes, takes out and is cooled to room temperature, be crushed to 40 orders, obtain hoopoe coarse powder and Cornu Naemorhedi coarse powder with pulverizer; Flos Nelumbinis being placed in dehydrator 60 ~ 70 DEG C dries to moisture lower than 5%, takes out and is cooled to room temperature, be broken to 40 orders, obtain Flos Nelumbinis coarse powder with pulverizer; Borneolum Syntheticum pulverizer is broken to 40 orders, obtains Borneolum Syntheticum coarse powder; With supersonic jet mill, gained hoopoe coarse powder, Cornu Naemorhedi coarse powder, Flos Nelumbinis coarse powder, Borneolum Syntheticum coarse powder are crushed to 1 ~ 50 μm, namely obtain described hoopoe micropowder, Cornu Naemorhedi micropowder, Flos Nelumbinis micropowder, Borneolum micropowder.
Further, described Herba Andrographis extract is andrographolide.
Further, described oenanthe javanica extract is Herba Apii graveolentis alkaloid, its preparation method is: pulverized by Herba Oenanthes Javanicae Semen Allii Tuberosi and after passing through 0.55 μm of sieves, reflux, extract, is carried out with the ethanol that mass concentration is 65 ~ 85%, solid-liquid ratio is 1g:(5 ~ 8) mL, extraction time is 1 ~ 2h, Extracting temperature is 45 DEG C, filter, filtrate after backflow decompression recycling ethanol again, regulate pH to 10 with the ammonia spirit that concentration is 25%, then use chloroform extraction 2 times in separatory funnel, merge chloroform extraction liquid and obtain Herba Apii graveolentis alkaloid.
Prepare the method that calm clearing away dryness of calming the nerves alleviates psychotic Chinese medicine composition, comprise the following steps:
(1) hoopoe and Cornu Naemorhedi are placed in 50 ~ 70 DEG C of low temperature in frying pan and bake 25 minutes, take out and be cooled to room temperature, be broken to 40 orders with pulverizer, obtain hoopoe coarse powder and Cornu Naemorhedi coarse powder; Flos Nelumbinis being placed in dehydrator 60 ~ 70 DEG C dries to moisture lower than 5%, takes out and is cooled to room temperature, be broken to 40 orders, obtain Flos Nelumbinis coarse powder with pulverizer; Borneolum Syntheticum pulverizer is broken to 40 orders, obtains Borneolum Syntheticum coarse powder; With supersonic jet mill, gained hoopoe coarse powder, Cornu Naemorhedi coarse powder, Flos Nelumbinis coarse powder, Borneolum Syntheticum coarse powder are crushed to 1 ~ 50 μm, namely obtain hoopoe micropowder, Cornu Naemorhedi micropowder, Flos Nelumbinis micropowder, Borneolum micropowder, stand-by;
(2) Herba Andrographis is ground into coarse powder, by 1g:(4 ~ 6) solid-liquid ratio of mL adds the ethanol that mass concentration is 95%, reflux, extract, 50 ~ 80 minutes are incubated in 55 DEG C, microwave radiation exaraction is adopted while alcohol reflux, microwave frequency is 62.5 ~ 80.4MHz, filtration after extraction completes, obtain medicinal residues and filtrate, medicinal residues are again by 1g:(4 ~ 6) solid-liquid ratio of mL adds the alcohol reflux 2 times that mass concentration is 85%, each 30 minutes, filter, merge three filtrates, concentrating under reduced pressure reclaims ethanol, decolouring, crystallize is placed in 2 ~ 10 DEG C, leaching crystallization, add 52 times amount acetone, reflux 15 ~ 25 minutes, filter insoluble matter, reclaim acetone completely, crystallize is placed in 2 ~ 10 DEG C, the crystallization of leaching white granular, be andrographolide.
(3) Herba Oenanthes Javanicae Semen Allii Tuberosi to be pulverized and after passing through 0.55 μm of sieves, reflux, extract, is carried out with the ethanol that mass concentration is 65 ~ 85%, solid-liquid ratio is 1g:(5 ~ 8) mL, extraction time is 1 ~ 2h, and Extracting temperature is 45 DEG C, filters, filtrate after backflow decompression recycling ethanol again, regulate pH to 10 with the ammonia spirit that concentration is 25%, then use chloroform extraction 2 times in separatory funnel, merge chloroform extraction liquid and obtain Herba Apii graveolentis alkaloid;
(4) flexuose bittercress herb and seed, Dregea yunnanensis (Tsiang) Tsiang, Radix Serissae, Rhodobryum giganteum(Hook.) Par., Plagiopus oederi (Brid.) Limpr.(Polytrichum annotinum L.), Radix Asparagi, Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendle, Fructus Dispyroris Loti, Paphio-pedilum micranthum Tang et Wang, Herba panici repentics, Lignum Poria, seabed cypress, rabbit hair Artemisia is taken by described proportioning, all medical materials are cut into the thin slice of 2mm, add the pure water of 11 ~ 15 times amount of described medical material gross weight, soak 12 ~ 15h, intense fire heated and boiled, slow fire boiling is extracted, decoct 2 ~ 3 hours, again add the pure water of 7 ~ 8 times amount, intense fire heated and boiled, slow fire boiling is extracted, and decocts 1 ~ 2 hour, merges the extracting solution of twice; Being condensed into relative density at 60 DEG C is the extractum of 0.84, the ethanol that mass concentration is 90 ~ 95% is added by the volume ratio of 1:1, stir, staticly settle 3 ~ 4h, filterability falls precipitate, stays supernatant, supernatant concentrating under reduced pressure reclaims ethanol, the density that obtains accompanying at 60 DEG C is the thick paste of 1.02 ~ 1.24, and spraying dry makes extract powder, stand-by;
(5) hoopoe micropowder, Cornu Naemorhedi micropowder, Flos Nelumbinis micropowder, the Borneolum micropowder of step (1) is taken by described proportioning, the Herba Andrographis extract of step (2) is taken by described proportioning, the oenanthe javanica extract of step (3) is taken by described proportioning, mix homogeneously with the extract powder of step (4), calm clearing away dryness of calming the nerves namely alleviates psychotic Chinese medicine composition.
Further, described calm clearing away dryness of calming the nerves is alleviated psychotic Chinese medicine composition and is prepared into oral formulations according to pharmacy conventional manner technique and adjuvant requirement, as tablet, granule, hard capsule, pill etc., conveniently take.
The present Research of the present invention's Chinese crude drug used is as follows:
Flexuose bittercress herb and seed: [source] medical material Ji Yuan: be the herb of crucifer Hairy Bittercress and bending Hairy Bittercress.[nature and flavor] are sweet; Light; Cool.[function cures mainly] clearing away heat-damp and promoting diuresis; Calm the nerves; Hemostasis.Main damp-heat dysentery; Pyretic stranguria; Leucorrhea; Cardiopalmus; Insomnia; Toothache caused by fire of deficiency type; Infantile malnutrition; Spit blood; Have blood in stool; Furuncle.
Dregea yunnanensis (Tsiang) Tsiang: [nature and flavor] are bitter; Pungent; Flat.[return through] liver; Stomach warp.[function cures mainly] calms the nerves; Spleen invigorating; Synthetism.Main neurasthenia; Inappetence; Fracture.
Lignum Poria: 1. " book on Chinese herbal medicine is looked for the truth ": bitter in the mouth, warm in nature.[function cures mainly] suppressing the hyperactive liver is calmed the nerves.Control palpitation with fear forgetful, aphasia due to apoplexy, beriberi is had a cramp." Chinese medicinal herbal ": mind tranquilizing and the heart calming.
Seabed cypress: [source] medical material Ji Yuan: be the colony of seabed Cupressaceae animal conspicuous Bai Helin seabed, color seabed cypress.[nature and flavor] sweet in the mouth; Micro-alkali; Cool in nature.[return through] liver; The heart; Lung meridian.[function cures mainly] cough-relieving is stopped blooding; Stomach function regulating antidiarrheal; Calm the nerves relieving convulsion.Main hemoptysis; Vomiting; Diarrhoea irritability; Palpitation with a distress feeling is confusing; Infantile convulsion [function cures mainly] cough-relieving is stopped blooding; Stomach function regulating antidiarrheal; Calm the nerves relieving convulsion.Main hemoptysis; Vomiting; Diarrhoea irritability; Palpitation with a distress feeling is confusing; Infantile convulsion.
Radix Serissae: " the SHENGCAO property of medicine is standby to be wanted ": bitter in the mouth, cold in nature.[function cures mainly] dispels the wind, dampness removing, heat clearing away, removing toxic substances." the SHENGCAO property of medicine is standby to be wanted ": cure the wound cold, heatstroke, gibberish of going mad, fiery disease, also moves back fever of the body.
Rhodobryum giganteum(Hook.) Par.: [source] warms up the herb of ground great Ye moss for Bryaceae plant.Xia Qiu gathers.[nature and flavor] work hard, flat.[function cures mainly] tranquillizing and allaying excitement, clear away heart-fire improving eyesight.Control heart disease, neurasthenia, sexual impotence.
Plagiopus oederi (Brid.) Limpr.(Polytrichum annotinum L.): [source] Bartramiaceae flat Bartramia plant flat pearl moss Plagiopusoederi (Gunn.) Limpr., with all herbal medicine.[nature and flavor] are light, flat.[function cures mainly] calmness peace is frightened.Control nervous vexed, epilepsy, aphasia due to apoplexy.[usage and dosage] takes orally: decoct soup, 2 ~ 3 money.
Radix Asparagi: [source] is the tuber of liliaceous plant Radix Asparagi." herbal classic ": bitter in the mouth, flat.[return through] enters lung, kidney channel.[function cures mainly] YIN nourishing, moisturizes, lung heat clearing, pathogenic fire reducing.Control fever due to yin deficiency, cough is spitted blood, and consumptive lung disease, lung abscess, laryngopharynx swelling and pain, quenches one's thirst, constipation.
Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendle: [nature and flavor] " book on Chinese herbal medicine is new again ": bitter in the mouth, cold in nature, nontoxic.[return through] " book on Chinese herbal medicine is new again ": enter the heart, liver two warp.[function cures mainly] to clear away heart-fire relieving restlessness, relieves heat and thirst.
Fructus Dispyroris Loti: [nature and flavor] are sweet, puckery is flat." Haiyao Bencao, Oversea Materia Medica ": master quenches one's thirst, dysphoria with smothery sensation, relieving palpitation.
Paphio-pedilum micranthum Tang et Wang: [nature and flavor] are bitter; Cool.[function cures mainly] heat-clearing and toxic substances removing, tranquilizing by nourishing the heart.Cure mainly measles, pneumonia, neurasthenia.[function cures mainly] clearing heat for promoting eruption; Clearing away heart-fire for tranquillization.Djumah rash; Pneumonia; Vexed insomnia." Xinhua book on Chinese herbal medicine outline ": herb: bitter in the mouth, cool in nature.There is heat-clearing and toxic substances removing, the function of cerebral tonic tranquillizing.For measles, pneumonia, neurasthenia.
Herba panici repentics: [source] grass family Herba panici repentics PanicumrepensL., is used as medicine with root stock.[nature and flavor] are sweet, flat.[function cures mainly] heat clearing away suppressing the hyperactive liver, eliminating damp, detoxifying.
Rabbit hair Artemisia: [source] Compositae rabbit hair Artemisia Filifoliumsibiricum (L.) Kitam., with all herbal medicine.[nature and flavor] are bitter, cold.[function cures mainly] heat-clearing and toxic substances removing, anti-inflammation, calms the nerves relieving convulsion, regulating menstruation, hemostasis.Heart beating, insomnia, neurasthenia's effect are shown.
Hoopoe: [source] coraciiformes Upupidae hoopoe UpupaepopsepopsL., is used as medicine with the entirety of unhairing and intestinal, stomach.[function cures mainly] softening liver for calming endogenous wind, tranquilizing mind.
Cornu Naemorhedi: [source] is the angle of bovid QINGYANG.[nature and flavor] salty in the mouth; Cold in nature.[return through] heart; Liver Channel.[function cures mainly] heat clearing away; Relieving convulsion; Eliminating stasis to stop pain.
Flos Nelumbinis: [nature and flavor] are bitter sweet, temperature." book on Chinese herbal medicine is new again ": clear away heart-fire removing heat from blood, relieving heat toxin controls infantile convulsion, and disappearing wets removes wind, controls skin ulcer scabies.
Borneolum Syntheticum: [nature and flavor] are pungent, bitter, are slightly cold.[return through] GUIXIN, spleen, lung meridian.[function cures mainly] has one's ideas straightened out refreshment, clearing away heat to alleviate pain.Faint for calentura coma, convulsion, apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, attacked by pestiferous factors is gone into a coma, and conjunctival congestion, aphtha, laryngopharynx swelling and pain, auditory meatus is suppurated.
Herba Andrographis extract: andrographolide: antipyretic, pathogenic fire purging, dampness, anti-inflammation.
Oenanthe javanica extract: Herba Apii graveolentis alkaloid has sedation, reduces spontaneous activity.
The invention has the beneficial effects as follows: it is by differential diagnosis in tcm method that calm clearing away dryness of calming the nerves of the present invention alleviates psychotic Chinese medicine composition, in conjunction with clinical experience, choose reasonable Chinese medicine, meticulously formulated, there is effect of cerebral tonic tranquillizing, softening liver for calming endogenous wind, calm clearing away dryness, clearing away heat-fire, relieving stress, the psychotic various symptom of effective alleviation, nurse one's health from inside to outside, the function of adjustment imbalance and disorderly meridian function, improve patients ' psychological stress ability, Be very effective, and drug effect is gentle, safety is high, has no side effect.
Detailed description of the invention
Embodiment 1:
One calm clearing away dryness of calming the nerves alleviates psychotic Chinese medicine composition, by weight, be prepared from by following composition: flexuose bittercress herb and seed 80 parts, Dregea yunnanensis (Tsiang) Tsiang 76 parts, Radix Serissae 75 parts, Rhodobryum giganteum(Hook.) Par. 70 parts, Plagiopus oederi (Brid.) Limpr.(Polytrichum annotinum L.) 64 parts, Radix Asparagi 22 parts, Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendle 20 parts, Fructus Dispyroris Loti 18 parts, Paphio-pedilum micranthum Tang et Wang 15 parts, Herba panici repentics 13 parts, Lignum Poria 12 parts, seabed cypress 9 parts, rabbit hair Artemisia 8 parts, hoopoe micropowder 6 parts, Cornu Naemorhedi micropowder 5 parts, Flos Nelumbinis micropowder 4 parts, Borneolum micropowder 3 parts, Herba Andrographis extract 0.2 part, oenanthe javanica extract 0.1 part.
Wherein, the particle diameter of described hoopoe micropowder, Cornu Naemorhedi micropowder, Flos Nelumbinis micropowder, Borneolum micropowder is 1 μm; Described Herba Andrographis extract is andrographolide; Described oenanthe javanica extract is Herba Apii graveolentis alkaloid.
Prepare the method that calm clearing away dryness of calming the nerves alleviates psychotic Chinese medicine composition, comprise the following steps:
(1) hoopoe and Cornu Naemorhedi are placed in 50 DEG C of low temperature in frying pan and bake 25 minutes, take out and be cooled to room temperature, be broken to 40 orders with pulverizer, obtain hoopoe coarse powder and Cornu Naemorhedi coarse powder; Flos Nelumbinis being placed in dehydrator 60 DEG C dries to moisture lower than 5%, takes out and is cooled to room temperature, be broken to 40 orders, obtain Flos Nelumbinis coarse powder with pulverizer; Borneolum Syntheticum pulverizer is broken to 40 orders, obtains Borneolum Syntheticum coarse powder; With supersonic jet mill, gained hoopoe coarse powder, Cornu Naemorhedi coarse powder, Flos Nelumbinis coarse powder, Borneolum Syntheticum coarse powder are crushed to 1 μm, namely obtain hoopoe micropowder, Cornu Naemorhedi micropowder, Flos Nelumbinis micropowder, Borneolum micropowder, stand-by;
(2) Herba Andrographis is ground into coarse powder, the ethanol that mass concentration is 95% is added by the solid-liquid ratio of 1g:4mL, reflux, extract, 50 minutes are incubated in 55 DEG C, microwave radiation exaraction is adopted while alcohol reflux, microwave frequency is 62.5MHz, filtration after extraction completes, obtain medicinal residues and filtrate, medicinal residues add by the solid-liquid ratio of 1g:4mL the alcohol reflux 2 times that mass concentration is 85% again, each 30 minutes, filter, merge three filtrates, concentrating under reduced pressure reclaims ethanol, decolouring, crystallize is placed in 2 DEG C, leaching crystallization, add 52 times amount acetone, reflux 15 minutes, filter insoluble matter, reclaim acetone completely, crystallize is placed in 2 DEG C, the crystallization of leaching white granular, be andrographolide.
(3) Herba Oenanthes Javanicae Semen Allii Tuberosi to be pulverized and after passing through 0.55 μm of sieves, reflux, extract, is carried out with the ethanol that mass concentration is 65%, solid-liquid ratio is 1g:5mL, extraction time is 1h, and Extracting temperature is 45 DEG C, filters, filtrate after backflow decompression recycling ethanol again, regulate pH to 10 with the ammonia spirit that concentration is 25%, then use chloroform extraction 2 times in separatory funnel, merge chloroform extraction liquid and obtain Herba Apii graveolentis alkaloid;
(4) flexuose bittercress herb and seed, Dregea yunnanensis (Tsiang) Tsiang, Radix Serissae, Rhodobryum giganteum(Hook.) Par., Plagiopus oederi (Brid.) Limpr.(Polytrichum annotinum L.), Radix Asparagi, Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendle, Fructus Dispyroris Loti, Paphio-pedilum micranthum Tang et Wang, Herba panici repentics, Lignum Poria, seabed cypress, rabbit hair Artemisia is taken by described proportioning, all medical materials are cut into the thin slice of 2mm, add the pure water of 11 times amount of described medical material gross weight, soak 12h, intense fire heated and boiled, slow fire boiling is extracted, decoct 2 hours, again add the pure water of 7 times amount, intense fire heated and boiled, slow fire boiling is extracted, and decocts 1 hour, merges the extracting solution of twice; Being condensed into relative density at 60 DEG C is the extractum of 0.84, the ethanol that mass concentration is 95% is added by the volume ratio of 1:1, stir, staticly settle 3h, filterability falls precipitate, stays supernatant, supernatant concentrating under reduced pressure reclaims ethanol, the density that obtains accompanying at 60 DEG C is the thick paste of 1.02, and spraying dry makes extract powder, stand-by;
(5) hoopoe micropowder, Cornu Naemorhedi micropowder, Flos Nelumbinis micropowder, the Borneolum micropowder of step (1) is taken by described proportioning, the Herba Andrographis extract of step (2) is taken by described proportioning, the oenanthe javanica extract of step (3) is taken by described proportioning, mix homogeneously with the extract powder of step (4), calm clearing away dryness of calming the nerves namely alleviates psychotic Chinese medicine composition.Again described calm clearing away dryness of calming the nerves is alleviated psychotic Chinese medicine composition and be prepared into tablet according to pharmacy conventional manner technique and adjuvant requirement.
Embodiment 2:
One calm clearing away dryness of calming the nerves alleviates psychotic Chinese medicine composition, by weight, be prepared from by following composition: flexuose bittercress herb and seed 115 parts, Dregea yunnanensis (Tsiang) Tsiang 108 parts, Radix Serissae 105 parts, Rhodobryum giganteum(Hook.) Par. 100 parts, Plagiopus oederi (Brid.) Limpr.(Polytrichum annotinum L.) 96 parts, Radix Asparagi 29 parts, Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendle 27.5 parts, Fructus Dispyroris Loti 24 parts, Paphio-pedilum micranthum Tang et Wang 20 parts, Herba panici repentics 17 parts, Lignum Poria 15 parts, seabed cypress 12 parts, rabbit hair Artemisia 10 parts, hoopoe micropowder 9 parts, Cornu Naemorhedi micropowder 7.5 parts, Flos Nelumbinis micropowder 6.5 parts, Borneolum micropowder 4.5 parts, Herba Andrographis extract 0.3 part, oenanthe javanica extract 0.2 part.
Wherein, the particle diameter of described hoopoe micropowder, Cornu Naemorhedi micropowder, Flos Nelumbinis micropowder, Borneolum micropowder is 1 ~ 50 μm; Described Herba Andrographis extract is andrographolide; Described oenanthe javanica extract is Herba Apii graveolentis alkaloid.
Prepare the method that calm clearing away dryness of calming the nerves alleviates psychotic Chinese medicine composition, comprise the following steps:
(1) hoopoe and Cornu Naemorhedi are placed in 60 DEG C of low temperature in frying pan and bake 25 minutes, take out and be cooled to room temperature, be broken to 40 orders with pulverizer, obtain hoopoe coarse powder and Cornu Naemorhedi coarse powder; Flos Nelumbinis being placed in dehydrator 65 DEG C dries to moisture lower than 5%, takes out and is cooled to room temperature, be broken to 40 orders, obtain Flos Nelumbinis coarse powder with pulverizer; Borneolum Syntheticum pulverizer is broken to 40 orders, obtains Borneolum Syntheticum coarse powder; With supersonic jet mill, gained hoopoe coarse powder, Cornu Naemorhedi coarse powder, Flos Nelumbinis coarse powder, Borneolum Syntheticum coarse powder are crushed to 25 μm, namely obtain hoopoe micropowder, Cornu Naemorhedi micropowder, Flos Nelumbinis micropowder, Borneolum micropowder, stand-by;
(2) Herba Andrographis is ground into coarse powder, the ethanol that mass concentration is 95% is added by the solid-liquid ratio of 1g:5mL, reflux, extract, 65 minutes are incubated in 55 DEG C, microwave radiation exaraction is adopted while alcohol reflux, microwave frequency is 71.5MHz, filtration after extraction completes, obtain medicinal residues and filtrate, medicinal residues are again by 1g:5) solid-liquid ratio of mL adds the alcohol reflux 2 times that mass concentration is 85%, each 30 minutes, filter, merge three filtrates, concentrating under reduced pressure reclaims ethanol, decolouring, crystallize is placed in 6 DEG C, leaching crystallization, add 52 times amount acetone, reflux 20 minutes, filter insoluble matter, reclaim acetone completely, crystallize is placed in 6 DEG C, the crystallization of leaching white granular, be andrographolide.
(3) Herba Oenanthes Javanicae Semen Allii Tuberosi to be pulverized and after passing through 0.55 μm of sieves, reflux, extract, is carried out with the ethanol that mass concentration is 75%, solid-liquid ratio is 1g:6.5mL, extraction time is 1.5h, and Extracting temperature is 45 DEG C, filters, filtrate after backflow decompression recycling ethanol again, regulate pH to 10 with the ammonia spirit that concentration is 25%, then use chloroform extraction 2 times in separatory funnel, merge chloroform extraction liquid and obtain Herba Apii graveolentis alkaloid;
(4) flexuose bittercress herb and seed, Dregea yunnanensis (Tsiang) Tsiang, Radix Serissae, Rhodobryum giganteum(Hook.) Par., Plagiopus oederi (Brid.) Limpr.(Polytrichum annotinum L.), Radix Asparagi, Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendle, Fructus Dispyroris Loti, Paphio-pedilum micranthum Tang et Wang, Herba panici repentics, Lignum Poria, seabed cypress, rabbit hair Artemisia is taken by described proportioning, all medical materials are cut into the thin slice of 2mm, add the pure water of 13 times amount of described medical material gross weight, soak 13.5h, intense fire heated and boiled, slow fire boiling is extracted, decoct 2.5 hours, again add the pure water of 7.5 times amount, intense fire heated and boiled, slow fire boiling is extracted, and decocts 1.5 hours, merges the extracting solution of twice; Being condensed into relative density at 60 DEG C is the extractum of 0.84, the ethanol that mass concentration is 92.5% is added by the volume ratio of 1:1, stir, staticly settle 3.5h, filterability falls precipitate, stays supernatant, supernatant concentrating under reduced pressure reclaims ethanol, the density that obtains accompanying at 60 DEG C is the thick paste of 1.13, and spraying dry makes extract powder, stand-by;
(5) hoopoe micropowder, Cornu Naemorhedi micropowder, Flos Nelumbinis micropowder, the Borneolum micropowder of step (1) is taken by described proportioning, the Herba Andrographis extract of step (2) is taken by described proportioning, the oenanthe javanica extract of step (3) is taken by described proportioning, mix homogeneously with the extract powder of step (4), calm clearing away dryness of calming the nerves namely alleviates psychotic Chinese medicine composition.Again described calm clearing away dryness of calming the nerves is alleviated psychotic Chinese medicine composition and be prepared into granule according to pharmacy conventional manner technique and adjuvant requirement.
Embodiment 3:
One calm clearing away dryness of calming the nerves alleviates psychotic Chinese medicine composition, by weight, be prepared from by following composition: flexuose bittercress herb and seed 150 parts, Dregea yunnanensis (Tsiang) Tsiang 140 parts, Radix Serissae 135 parts, Rhodobryum giganteum(Hook.) Par. 130 parts, Plagiopus oederi (Brid.) Limpr.(Polytrichum annotinum L.) 128 parts, Radix Asparagi 36 parts, Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendle 35 parts, Fructus Dispyroris Loti 30 parts, Paphio-pedilum micranthum Tang et Wang 25 parts, Herba panici repentics 21 parts, Lignum Poria 18 parts, seabed cypress 15 parts, rabbit hair Artemisia 12 parts, hoopoe micropowder 12 parts, Cornu Naemorhedi micropowder 10 parts, Flos Nelumbinis micropowder 9 parts, Borneolum micropowder 6 parts, Herba Andrographis extract 0.4 part, oenanthe javanica extract 0.3 part.
Wherein, the particle diameter of described hoopoe micropowder, Cornu Naemorhedi micropowder, Flos Nelumbinis micropowder, Borneolum micropowder is 50 μm; Described Herba Andrographis extract is andrographolide; Described oenanthe javanica extract is Herba Apii graveolentis alkaloid.
Prepare the method that calm clearing away dryness of calming the nerves alleviates psychotic Chinese medicine composition, comprise the following steps:
(1) hoopoe and Cornu Naemorhedi are placed in 70 DEG C of low temperature in frying pan and bake 25 minutes, take out and be cooled to room temperature, be broken to 40 orders with pulverizer, obtain hoopoe coarse powder and Cornu Naemorhedi coarse powder; Flos Nelumbinis being placed in dehydrator 70 DEG C dries to moisture lower than 5%, takes out and is cooled to room temperature, be broken to 40 orders, obtain Flos Nelumbinis coarse powder with pulverizer; Borneolum Syntheticum pulverizer is broken to 40 orders, obtains Borneolum Syntheticum coarse powder; With supersonic jet mill, gained hoopoe coarse powder, Cornu Naemorhedi coarse powder, Flos Nelumbinis coarse powder, Borneolum Syntheticum coarse powder are crushed to 50 μm, namely obtain hoopoe micropowder, Cornu Naemorhedi micropowder, Flos Nelumbinis micropowder, Borneolum micropowder, stand-by;
(2) Herba Andrographis is ground into coarse powder, the ethanol that mass concentration is 95% is added by the solid-liquid ratio of 1g:6mL, reflux, extract, 80 minutes are incubated in 55 DEG C, microwave radiation exaraction is adopted while alcohol reflux, microwave frequency is 80.4MHz, filtration after extraction completes, obtain medicinal residues and filtrate, medicinal residues add by the solid-liquid ratio of 1g:6mL the alcohol reflux 2 times that mass concentration is 85% again, each 30 minutes, filter, merge three filtrates, concentrating under reduced pressure reclaims ethanol, decolouring, crystallize is placed in 10 DEG C, leaching crystallization, add 52 times amount acetone, reflux 25 minutes, filter insoluble matter, reclaim acetone completely, crystallize is placed in 10 DEG C, the crystallization of leaching white granular, be andrographolide.
(3) Herba Oenanthes Javanicae Semen Allii Tuberosi to be pulverized and after passing through 0.55 μm of sieves, reflux, extract, is carried out with the ethanol that mass concentration is 85%, solid-liquid ratio is 1g:8mL, extraction time is 2h, and Extracting temperature is 45 DEG C, filters, filtrate after backflow decompression recycling ethanol again, regulate pH to 10 with the ammonia spirit that concentration is 25%, then use chloroform extraction 2 times in separatory funnel, merge chloroform extraction liquid and obtain Herba Apii graveolentis alkaloid;
(4) flexuose bittercress herb and seed, Dregea yunnanensis (Tsiang) Tsiang, Radix Serissae, Rhodobryum giganteum(Hook.) Par., Plagiopus oederi (Brid.) Limpr.(Polytrichum annotinum L.), Radix Asparagi, Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendle, Fructus Dispyroris Loti, Paphio-pedilum micranthum Tang et Wang, Herba panici repentics, Lignum Poria, seabed cypress, rabbit hair Artemisia is taken by described proportioning, all medical materials are cut into the thin slice of 2mm, add the pure water of 15 times amount of described medical material gross weight, soak 15h, intense fire heated and boiled, slow fire boiling is extracted, decoct 3 hours, again add the pure water of 8 times amount, intense fire heated and boiled, slow fire boiling is extracted, and decocts 2 hours, merges the extracting solution of twice; Being condensed into relative density at 60 DEG C is the extractum of 0.84, the ethanol that mass concentration is 95% is added by the volume ratio of 1:1, stir, staticly settle 4h, filterability falls precipitate, stays supernatant, supernatant concentrating under reduced pressure reclaims ethanol, the density that obtains accompanying at 60 DEG C is the thick paste of 1.24, and spraying dry makes extract powder, stand-by;
(5) hoopoe micropowder, Cornu Naemorhedi micropowder, Flos Nelumbinis micropowder, the Borneolum micropowder of step (1) is taken by described proportioning, the Herba Andrographis extract of step (2) is taken by described proportioning, the oenanthe javanica extract of step (3) is taken by described proportioning, mix homogeneously with the extract powder of step (4), calm clearing away dryness of calming the nerves namely alleviates psychotic Chinese medicine composition.Again described calm clearing away dryness of calming the nerves is alleviated psychotic Chinese medicine composition and be prepared into hard capsule according to pharmacy conventional manner technique and adjuvant requirement.
Clinical treatment case:
1, psychotic land, 43 years old, suffers from intermittent insanity, during morbidity, usually murmur to oneself, behavior is strange, emotion is excited, lather, treat all ineffective for many years, start to take prepared by the embodiment of the present invention 1 calm clearing away dryness of calming the nerves in March, 2012 to alleviate psychotic Chinese medicine composition tablet and treat, its period of disease at a time when treatment, each 1.0 grams, once a day, after taking one week, the state of an illness makes moderate progress, be emotionally stable, but still murmur to oneself, behavior is strange, continue to take medicine of the present invention after 2 weeks, all symptoms alleviate all greatly, continue to take medicine of the present invention after 4 weeks, emotion complete stability, look is as ordinary person, behavior is normal, continuous Drug therapy of the present invention 2 months, so far do not recur.
2, psychotic's beam so-and-so, 36 years old, because domestic calamity before 5 years is upset, from then on psychosis has been suffered from after, soliloquy during patient, have a dull expression on one's face, time and manic uneasiness, speaking incoherently, even ruin thing to hurt sb.'s feelings, start to take prepared by the embodiment of the present invention 2 calm clearing away dryness of calming the nerves in June, 2012 to alleviate psychotic Chinese medicinal composition granules and treat, each 6 grams, once a day, after taking one week, the state of an illness makes moderate progress, be emotionally stable, no longer manic, but speech and expression still abnormal, behavior is strange, continue to take medicine of the present invention after 2 weeks, all symptoms alleviate all greatly, emotion quite stable, speech and behavior all recover normal, continue to take medicine of the present invention after 4 weeks, emotion complete stability, look is as ordinary person, behavior is normal, continuous Drug therapy of the present invention 2 months, cure, life is normal, so far do not recur.
3, psychotic, Yuan so-and-so, 62 years old, the entanglement of patient's mind, short-tempered, frequent ignition temper is large, even hit the person, fall thing, lie awake all night, start to take prepared by the embodiment of the present invention 3 calm clearing away dryness of calming the nerves in May, 2012 to alleviate psychotic Chinese medicine composition hard capsule and treat, after one week, patient is emotionally stable gentle, the length of one's sleep extends to some extent, after continuation medication treats 2 weeks, temper becomes gentle, occur without breaking phenomenon, after continuation medication treats 4 weeks, patient not easily flares up, sleep is normal, behavior and speech are all as good as with ordinary person, continue medication treatment after 2 months, thorough healing, recover normal Working Life, so far do not recur.
Illustrate disclosed example, those skilled in the art can grasp and realize primary claim of the present invention.To the amendment of body construction multiple in example with to make one of skill in the art be apparent, base station applies principle proposed by the invention is in the range of application that do not lose contact with reality, all realization can be applied in other instances.The present invention can not be limited to example shown in this article, but accord with principle disclosed herein and the consistent most wide region of innovation and application.
Claims (6)
1. a calm clearing away dryness of calming the nerves alleviates psychotic Chinese medicine composition, it is characterized in that, by weight, it is be prepared from by following composition: flexuose bittercress herb and seed 80 ~ 150 parts, Dregea yunnanensis (Tsiang) Tsiang 76 ~ 140 parts, Radix Serissae 75 ~ 135 parts, Rhodobryum giganteum(Hook.) Par. 70 ~ 130 parts, Plagiopus oederi (Brid.) Limpr.(Polytrichum annotinum L.) 64 ~ 128 parts, Radix Asparagi 22 ~ 36 parts, Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendle 20 ~ 35 parts, Fructus Dispyroris Loti 18 ~ 30 parts, Paphio-pedilum micranthum Tang et Wang 15 ~ 25 parts, Herba panici repentics 13 ~ 21 parts, Lignum Poria 12 ~ 18 parts, seabed cypress 9 ~ 15 parts, rabbit hair Artemisia 8 ~ 12 parts, hoopoe micropowder 6 ~ 12 parts, Cornu Naemorhedi micropowder 5 ~ 10 parts, Flos Nelumbinis micropowder 4 ~ 9 parts, Borneolum micropowder 3 ~ 6 parts, Herba Andrographis extract 0.2 ~ 0.4 part, oenanthe javanica extract 0.1 ~ 0.3 part.
2. one according to claim 1 calm clearing away dryness of calming the nerves alleviates psychotic Chinese medicine composition, it is characterized in that, by weight, it is be prepared from by following composition: flexuose bittercress herb and seed 115 parts, Dregea yunnanensis (Tsiang) Tsiang 108 parts, Radix Serissae 105 parts, Rhodobryum giganteum(Hook.) Par. 100 parts, Plagiopus oederi (Brid.) Limpr.(Polytrichum annotinum L.) 96 parts, Radix Asparagi 29 parts, Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendle 27.5 parts, Fructus Dispyroris Loti 24 parts, Paphio-pedilum micranthum Tang et Wang 20 parts, Herba panici repentics 17 parts, Lignum Poria 15 parts, seabed cypress 12 parts, rabbit hair Artemisia 10 parts, hoopoe micropowder 9 parts, Cornu Naemorhedi micropowder 7.5 parts, Flos Nelumbinis micropowder 6.5 parts, Borneolum micropowder 4.5 parts, Herba Andrographis extract 0.3 part, oenanthe javanica extract 0.2 part.
3. one according to claim 1 and 2 calm clearing away dryness of calming the nerves alleviates psychotic Chinese medicine composition, and it is characterized in that, the particle diameter of described hoopoe micropowder, Cornu Naemorhedi micropowder, Flos Nelumbinis micropowder, Borneolum micropowder is 1 ~ 50 μm; Preparation method is: hoopoe and Cornu Naemorhedi are placed in 50 ~ 70 DEG C of low temperature in frying pan and bake 25 minutes, takes out and is cooled to room temperature, be crushed to 40 orders, obtain hoopoe coarse powder and Cornu Naemorhedi coarse powder with pulverizer; Flos Nelumbinis being placed in dehydrator 60 ~ 70 DEG C dries to moisture lower than 5%, takes out and is cooled to room temperature, be broken to 40 orders, obtain Flos Nelumbinis coarse powder with pulverizer; Borneolum Syntheticum pulverizer is broken to 40 orders, obtains Borneolum Syntheticum coarse powder; With supersonic jet mill, gained hoopoe coarse powder, Cornu Naemorhedi coarse powder, Flos Nelumbinis coarse powder, Borneolum Syntheticum coarse powder are crushed to 1 ~ 50 μm, namely obtain described hoopoe micropowder, Cornu Naemorhedi micropowder, Flos Nelumbinis micropowder, Borneolum micropowder.
4. one according to claim 1 and 2 calm clearing away dryness of calming the nerves alleviates psychotic Chinese medicine composition, and it is characterized in that, described Herba Andrographis extract is andrographolide.
5. one according to claim 1 and 2 calm clearing away dryness of calming the nerves alleviates psychotic Chinese medicine composition, it is characterized in that, described oenanthe javanica extract is Herba Apii graveolentis alkaloid, its preparation method is: pulverized by Herba Oenanthes Javanicae Semen Allii Tuberosi and after passing through 0.55 μm of sieves, carry out reflux, extract, the decompression recycling ethanol again of the filtrate after backflow, regulate pH to 10 with ammonia spirit, in separatory funnel, use chloroform extraction 2 times again, merge chloroform extraction liquid and obtain Herba Apii graveolentis alkaloid.
6. the calm clearing away dryness of calming the nerves prepared as described in claim 1 ~ 6 alleviates a method for psychotic Chinese medicine composition, it is characterized in that, comprises the following steps:
(1) hoopoe and Cornu Naemorhedi are placed in 50 ~ 70 DEG C of low temperature in frying pan and bake 25 minutes, take out and be cooled to room temperature, be broken to 40 orders with pulverizer, obtain hoopoe coarse powder and Cornu Naemorhedi coarse powder; Flos Nelumbinis being placed in dehydrator 60 ~ 70 DEG C dries to moisture lower than 5%, takes out and is cooled to room temperature, be broken to 40 orders, obtain Flos Nelumbinis coarse powder with pulverizer; Borneolum Syntheticum pulverizer is broken to 40 orders, obtains Borneolum Syntheticum coarse powder; With supersonic jet mill, gained hoopoe coarse powder, Cornu Naemorhedi coarse powder, Flos Nelumbinis coarse powder, Borneolum Syntheticum coarse powder are crushed to 1 ~ 50 μm, namely obtain hoopoe micropowder, Cornu Naemorhedi micropowder, Flos Nelumbinis micropowder, Borneolum micropowder, stand-by;
(2) Herba Andrographis is ground into coarse powder, by 1g:(4 ~ 6) solid-liquid ratio of mL adds the ethanol that mass concentration is 95%, reflux, extract, 50 ~ 80 minutes are incubated in 55 DEG C, microwave radiation exaraction is adopted while alcohol reflux, microwave frequency is 62.5 ~ 80.4MHz, filtration after extraction completes, obtain medicinal residues and filtrate, medicinal residues are again by 1g:(4 ~ 6) solid-liquid ratio of mL adds the alcohol reflux 2 times that mass concentration is 85%, each 30 minutes, filter, merge three filtrates, concentrating under reduced pressure reclaims ethanol, decolouring, crystallize is placed in 2 ~ 10 DEG C, leaching crystallization, add 52 times amount acetone, reflux 15 ~ 25 minutes, filter insoluble matter, reclaim acetone completely, crystallize is placed in 2 ~ 10 DEG C, the crystallization of leaching white granular, be andrographolide.
(3) Herba Oenanthes Javanicae Semen Allii Tuberosi to be pulverized and after passing through 0.55 μm of sieves, carry out reflux, extract, the filtrate after backflow, at decompression recycling ethanol, regulates pH to 10 with ammonia spirit, in separatory funnel, use chloroform extraction 2 times again, merge chloroform extraction liquid and obtain Herba Apii graveolentis alkaloid.
(4) flexuose bittercress herb and seed, Dregea yunnanensis (Tsiang) Tsiang, Radix Serissae, Rhodobryum giganteum(Hook.) Par., Plagiopus oederi (Brid.) Limpr.(Polytrichum annotinum L.), Radix Asparagi, Phyllostachys nigra (Lodd.) Munrovar.henonis(Mitf.) Stapfex Rendle, Fructus Dispyroris Loti, Paphio-pedilum micranthum Tang et Wang, Herba panici repentics, Lignum Poria, seabed cypress, rabbit hair Artemisia is taken by described proportioning, all medical materials are cut into the thin slice of 2mm, add the pure water of 11 ~ 15 times amount of described medical material gross weight, soak 12 ~ 15h, intense fire heated and boiled, slow fire boiling is extracted, decoct 2 ~ 3 hours, again add the pure water of 7 ~ 8 times amount, intense fire heated and boiled, slow fire boiling is extracted, and decocts 1 ~ 2 hour, merges the extracting solution of twice; Being condensed into relative density at 60 DEG C is the extractum of 0.84, the ethanol that mass concentration is 90 ~ 95% is added by the volume ratio of 1:1, stir, staticly settle 3 ~ 4h, filterability falls precipitate, stays supernatant, supernatant concentrating under reduced pressure reclaims ethanol, the density that obtains accompanying at 60 DEG C is the thick paste of 1.02 ~ 1.24, and spraying dry makes extract powder, stand-by;
(5) hoopoe micropowder, Cornu Naemorhedi micropowder, Flos Nelumbinis micropowder, the Borneolum micropowder of step (1) is taken by described proportioning, the Herba Andrographis extract of step (2) is taken by described proportioning, the oenanthe javanica extract of step (3) is taken by described proportioning, mix homogeneously with the extract powder of step (4), calm clearing away dryness of calming the nerves namely alleviates psychotic Chinese medicine composition.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106266445A (en) * | 2016-11-07 | 2017-01-04 | 四会市恒星智能科技有限公司 | A kind of Chinese medicine composition for improving sow natural labor rate |
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| CN1142378A (en) * | 1995-08-09 | 1997-02-12 | 滕培亮 | Medicine for psychosis |
| CN1198942A (en) * | 1998-03-04 | 1998-11-18 | 王昌运 | Soothing and vexation relieving capsule and its preparation method |
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| CN106266445A (en) * | 2016-11-07 | 2017-01-04 | 四会市恒星智能科技有限公司 | A kind of Chinese medicine composition for improving sow natural labor rate |
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